923 results on '"Roos S"'
Search Results
152. Does dye laser treatment with higher fluences in combination with cold air cooling improve the results of port-wine stains?
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Hammes, S, Roos, S, Raulin, C, Ockenfels, H-M, and Greve, B
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- 2007
153. Pulsed dye laser: whatʼs new in non-vascular lesions?
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Karsai, S, Roos, S, Hammes, S, and Raulin, C
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- 2007
154. Materials failure mechanisms of hybrid ball bearings with silicon nitride balls
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Thoma, K., Rohr, L., Rehmann, H., Roos, S., and Michler, J.
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- 2004
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155. Improving the life cycle impact assessment of metal ecotoxicity : Importance of chromium speciation, water chemistry, and metal release
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Hedberg, Jonas, Fransson, K., Prideaux, Sonja, Roos, S., Jönsson, C., Odnevall Wallinder, Inger, Hedberg, Jonas, Fransson, K., Prideaux, Sonja, Roos, S., Jönsson, C., and Odnevall Wallinder, Inger
- Abstract
Investigations of metal ecotoxicity in life cycle assessment (LCA) and life cycle impact assessment (LCIA) are becoming important tools for evaluating the environmental impact of a product or process. There is, however, improvement needed for LCIA of metal ecotoxicity in order to make this assessment more relevant and robust. In this work, three issues within the LCIA of metal ecotoxicity are investigated, mainly focusing on topics related to stainless steel manufacturing. The first issue is the importance of considering regional water chemistry when constructing the characterization factor (CF). A model freshwater of relevance for stainless steel manufacturing in a region of Sweden was created with chemistry different from available options. The second issue is related to the lack of consideration on changes in speciation of Cr(VI) in freshwater for a given emission, as Cr(VI) to some extent will be reduced to Cr(III). Two new options are suggested based on relationships between the Cr(VI)-total Cr ratio as a way to improve the relevancy of LCIA for Cr(VI) in freshwater. The last issue is how to treat metal release from slags in LCIA. Metal release from slags was shown to vary significantly between different ways of modelling slag emissions (differences in total metal content, slag leaching tests, estimated emissions to groundwater)., QC20190612
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- 2019
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156. Attack-resistant Spanning Tree Construction in Route-Restricted Overlay Networks
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Byrenheid, Martin (author), Roos, S. (author), Strufe, Thorsten (author), Byrenheid, Martin (author), Roos, S. (author), and Strufe, Thorsten (author)
- Abstract
Nodes in route-restricted overlays have an im-mutable set of neighbors, explicitly specified by their users. Pop-ular examples include payment networks such as the Lightningnetwork as well as social overlays such as the Dark Freenet.Routing algorithms are central to such overlays as they enablecommunication between nodes that are not directly connected.Recent results show that algorithms based on spanning treesare the most promising provably efficient choice. However, allsuggested solutions fail to address how distributed spanning treealgorithms can deal with active denial of service attacks bymalicious nodes.In this work, we design a novel self-stabilizing spanning treeconstruction algorithm that utilizes cryptographic signatures andprove that it reduces the set of nodes affected by active attacks.Our simulations substantiate this theoretical result withconcretevalues based on real-world data sets. In particular, our resultsindicate that our algorithm reduces the number of affectednodes by up to 74% compared to state-of-the-art attack-resistantspanning tree constructions, Distributed Systems
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- 2019
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157. Droogte door klimaatverandering voor Waterschap Rijn en IJssel : een inschatting van het effect op de grond- en oppervlaktewaterstanden
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Roos, S. de and Roos, S. de
- Abstract
In dit eindrapport is de impact van klimaatverandering onderzocht op 15 watergangen die worden beheerd door Waterschap Rijn en IJssel (WRIJ). Er is hierbij gebruik gemaakt van grondwaterstand-, waterstand- en weerobservaties, afkomstig van onder andere WRIJ en het KNMI, maar ook andere externe bronnen zijn geraadpleegd. Het onderzoek dient als indicatie voor WRIJ en heeft uitgezocht bij welke watergangen droogte door klimaatverandering tot 2100 de meeste impact zal gaan geven en in welke mate deze impact zich zal uiten.
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- 2019
158. Circulaire Atlas Gelderland : rapportage
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Jutte, J.B., Euler-van Hulst, K., Roos, S., Jutte, J.B., Euler-van Hulst, K., and Roos, S.
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Het coalitieakkoord 2019-2023 ’Samen voor Gelderland’ zet via verschillende gebundelde sporen in op de circulaire economie. Bijvoorbeeld als onderdeel van de landbouw- en voedseltransitie (kringlooplandbouw). Maar ook in haar rol als vergunningverlener, toezichthouder en handhaver moet van afval weer grondstoffen worden gemaakt en belemmeringen worden weggenomen. Ook in de woningopgave is nadrukkelijk aandacht voor circulariteit en het hergebruik van materialen. Om van Gelderland een echt circulaire economie te maken, wil de coalitie inzetten op een snelle transformatie van de grootste geïmporteerde grondstofstromen naar circulair en hergebruik.
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- 2019
159. Mitogen-Activated Protein Kinase (MAPK) Phosphatase-1 and -4 Attenuate p38 MAPK during Dexamethasone-Induced Insulin Resistance in 3T3-L1 Adipocytes
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Bazuine, Merlijn, Carlotti, Françoise, Tafrechi, Roos S. Jahangir, Hoeben, Rob C., and Maassen, J Antonie
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- 2004
160. Anti Helicobacter pylori Activity Among lactic Acid Bacteria Isolated from Gastric Biopsies and Strains of Lactobacillus reuteri
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Johnson, C., Jonsson, H., and Roos, S.
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- 2003
161. High urinary sulfate concentration is associated with reduced risk of renal disease progression in type 2 diabetes
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Jan-Luuk Hillebrands, Anne-Roos S. Frenay, Joost C. van den Born, Stephan J. L. Bakker, Hiddo J.L. Heerspink, Harry van Goor, Andreas Pasch, Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Methods in Medicines evaluation & Outcomes research (M2O), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
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0301 basic medicine ,Male ,Cancer Research ,BLOOD ,Physiology ,Epidemiology ,Clinical Biochemistry ,HOMOCYSTEINE ,Diabetic nephropathy ,urologic and male genital diseases ,Biochemistry ,chemistry.chemical_compound ,Hemoglobins ,Diabetic Nephropathies ,INSULIN-RESISTANCE ,EXCRETION ,Hydrogen sulfide ,Sulfates ,H2S ,Type 2 diabetes ,Middle Aged ,End stage renal disease ,Creatinine ,Disease Progression ,SKELETAL-MUSCLE ,Female ,medicine.symptom ,Glomerular Filtration Rate ,medicine.medical_specialty ,NEPHROPATHY ,Urinary system ,Urology ,Renal function ,HYDROGEN-SULFIDE ,Nephropathy ,03 medical and health sciences ,Internal medicine ,medicine ,Albuminuria ,Humans ,Renal Insufficiency, Chronic ,CARDIOVASCULAR EVENTS ,Serum Albumin ,Aged ,business.industry ,medicine.disease ,Sulfate ,030104 developmental biology ,Endocrinology ,chemistry ,Diabetes Mellitus, Type 2 ,ISCHEMIA/REPERFUSION ,business ,Kidney disease - Abstract
Diabetes is associated with a high incidence of microvascular disease, including nephropathy. Diabetic nephropathy is the most common cause of chronic kidney disease in the Western world. Sulfate in the urine is the metabolic end product of hydrogen sulfide (H2S), a recent discovered gaseous signaling molecule. Urinary sulfate has earlier shown beneficial predictive properties in renal transplant recipients. Based on the protective role of exogenous H2S in experimental models of diabetic nephropathy, we aimed to cross-sectionally investigate the association of sulfate with renal risk markers, and to prospectively investigate its predictive value for renal events in patients with diabetic nephropathy.Post-hoc analysis on data of the sulodexide macroalbuminuria (Sun-MACRO) trial and the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study was performed. A total of 1004 patients with type 2 diabetes were included. Urinary sulfate concentration was measured and cross-sectionally associated to renal risk markers by linear regression. Multivariable Cox regression analysis was performed to assess the prospective association of sulfate with renal events, which was defined as end stage renal disease or a doubling of baseline serum creatinine.Mean age was 63 +/- 9 years, median sulfate concentration was 8.0 (IQR 5.8-11.4) mmol/L. Urinary sulfate positively associated with male gender, hemoglobin, and negatively associated with albuminuria at baseline. During follow-up for 12 (IQR 6-18) months, 38 renal events occurred. Each doubling of urinary sulfate was associated with a 19% (95%Cl 1%-34%) lower risk of renal events, independent of adjustment for potential confounders, including age, estimated glomerular filtration rate (eGFR), and albuminuria.To conclude, higher urinary sulfate concentration is associated with a more beneficial profile of renal risk markers, and is independently associated with a reduced risk for renal events in type 2 diabetes patients with nephropathy. (C) 2016 Elsevier Inc. All rights reserved.
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- 2016
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162. Author Correction: Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Jenny E. Kootstra-Ros, Ido P. Kema, Isidor Minović, Anne-Roos S. Frenay, Else van den Berg, Stephan J. L. Bakker, Gerjan Navis, Carlo A. J. M. Gaillard, Andrew P. Levy, Gerald Rimbach, Johanna M. Geleijnse, Ineke J. Riphagen, Tuba Esatbeyoglu, Manfred Eggersdorfer, Harry van Goor, and Michele F Eisenga
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Male ,Nutrition and Disease ,Science ,Text mining ,Voeding en Ziekte ,medicine ,Humans ,Life Science ,Author Correction ,VLAG ,Metabolic Syndrome ,Multidisciplinary ,biology ,Haptoglobins ,business.industry ,Haptoglobin ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Treatment Outcome ,Renal transplant ,Immunology ,biology.protein ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Medicine ,Female ,Metabolic syndrome ,business ,Biomarkers - Abstract
Haptoglobin (Hp) is an acute phase protein that has recently been linked to components of the metabolic syndrome (MetS). We aimed to evaluate Hp as marker of MetS, and to assess its association with long-term outcome in renal transplant recipients (RTR). We measured plasma Hp in a prospective cohort of 699 stable RTR and 149 healthy controls. Median plasma Hp concentration in RTR was 1.4 [interquartile range (IQR), 1.0-1.8] g/L, which was higher compared to 1.1 [0.9-1.4] g/L in controls (P 0.001). Hp was independently associated with the MetS (β = 0.10) (P = 0.005). During follow-up of 5.4 [4.8-6.1] years, 150 (21%) recipients died, of whom 60 (9%) due to cardiovascular causes, and 83 (12%) RTR developed graft failure. High (≥2.0 g/L) and low (≤0.9 g/L) plasma Hp were associated with increased risk of mortality (HR's 2.3 [1.3-4.1] and 1.9 [1.0-3.5], resp.), predominantly cardiovascular. The association of high Hp lost significance upon adjustment for inflammation markers (HR 1.5 [0.8-2.7]), while low Hp was independently associated with mortality (HR 2.2 [1.2-4.0]). Hp was not associated with graft failure (P = 0.49). In conclusion, plasma Hp is independently associated with MetS in RTR. Importantly, high and low Hp are associated with increased mortality risk, independent of MetS.
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- 2018
163. Dirac operators with W1,∞-potential on collapsing sequences losing one dimension in the limit
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Roos, S.
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- 2018
164. The Dirac operator under collapse with bounded curvature and diameter
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Roos, S.
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Mathematics::Differential Geometry - Abstract
A sequence (Mi, gi)i of closed Riemannian manifolds with uniform bounded curvature and diameter collapses if it converges to a lower dimensional compact metric space (B,h). The limit space (B,h) has in general many singularities. In the first part of this thesis we show that the case, where the limit space (B,h) is at most of one dimension less, can be characterized by a uniform lower bound on the quotient of the volume of the manifoldsi divided by their injectivity radius. In that case the limit space (B,h) is a Riemannian orbifold. In the second part, we discuss the behavior of Dirac eigenvalues on a collapsing sequence of spin manifolds with bounded curvature and diameter converging to a lower dimensional Riemannian manifold (B,h). Lott showed that the spectrum of Dirac type operators converges to the spectrum of a certain first order elliptic differential operator D on B. We accentuate this result in the case of spin manifolds by giving an explicit description of the differential operator D and conclude that D is self-adjoint. Moreover we characterize the special case where D is the Dirac operator on B.
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- 2018
165. Urinary Excretion of Sulfur Metabolites and Risk of Cardiovascular Events and All-Cause Mortality in the General Population
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van den Born, Joost C., primary, Frenay, Anne-Roos S., additional, Koning, Anne M., additional, Bachtler, Matthias, additional, Riphagen, Ineke J., additional, Minovíc, Isidor, additional, Feelisch, Martin, additional, Dekker, Marinda M., additional, Bulthuis, Marian L.C., additional, Gansevoort, Ron. T., additional, Hillebrands, Jan-Luuk, additional, Pasch, Andreas, additional, Bakker, Stephan J.L., additional, and van Goor, Harry, additional
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- 2019
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166. Plasma ADMA associates with all-cause mortality in renal transplant recipients
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Bibiana Beckmann, Martin Feelisch, Dimitrios Tsikas, Harry van Goor, Stephan J. L. Bakker, Gerjan Navis, Else van den Berg, Martin H. de Borst, Anne-Roos S. Frenay, Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Groningen Institute for Organ Transplantation (GIOT), and Value, Affordability and Sustainability (VALUE)
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Graft Rejection ,Male ,CHRONIC KIDNEY-DISEASE ,Asymmetric dimethylarginine ,Survival ,Clinical Biochemistry ,PROGRESSION ,Kidney ,Biochemistry ,Gastroenterology ,METABOLITES ,chemistry.chemical_compound ,Medicine ,Endothelial dysfunction ,Kidney transplantation ,RISK ,ASYMMETRIC DIMETHYLARGININE ADMA ,Middle Aged ,Survival Rate ,medicine.anatomical_structure ,Female ,Original Article ,Adult ,medicine.medical_specialty ,Arginine ,Models, Biological ,Disease-Free Survival ,Internal medicine ,Humans ,NITRIC-OXIDE SYNTHASE ,Survival rate ,Aged ,Transplantation ,HYPERTENSION ,business.industry ,Proportional hazards model ,Organic Chemistry ,medicine.disease ,Kidney Transplantation ,Blood pressure ,Endocrinology ,chemistry ,ENDOTHELIAL DYSFUNCTION ,Endothelium, Vascular ,business ,Follow-Up Studies ,GROWTH-FACTOR 23 - Abstract
Asymmetric dimethylarginine (ADMA) is a key endogenous inhibitor of endothelial NO synthase that affects endothelial function, blood pressure and vascular remodeling. Increased plasma levels of ADMA are associated with worse outcome from cardiovascular disease. Due to endothelial dysfunction before and after kidney transplantation, renal transplant recipients (RTR) are at high risk for the alleged deleterious effects of ADMA. We investigated the associations of ADMA levels with all-cause mortality and graft failure in RTR. Plasma ADMA levels were determined in 686 stable outpatient RTR (57 % male, 53 +/- A 13 years), with a functioning graft for a parts per thousand yen1 year. Determinants of ADMA were evaluated with multivariate linear regression models. Associations between ADMA and mortality were assessed using multivariable Cox regression analyses. The strongest associations with plasma ADMA in the multivariable analyses were male gender, donor age, parathyroid hormone, NT-pro-BNP and use of calcium supplements. During a median follow-up of 3.1 [2.7-3.9] years, 79 (12 %) patients died and 45 (7 %) patients developed graft failure. ADMA was associated with increased all-cause mortality [HR 1.52 (95 % CI 1.26-1.83] per SD increase, P
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- 2015
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167. Hydrogen sulfide in renal physiology, disease and transplantation - The smell of renal protection
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Anne-Roos S. Frenay, Anne M. Koning, Henri G. D. Leuvenink, and Harry van Goor
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CHRONIC KIDNEY-DISEASE ,Cancer Research ,medicine.medical_specialty ,Physiology ,Clinical Biochemistry ,GAMMA-LYASE ,CSE ,ISCHEMIA-REPERFUSION INJURY ,HEMODIALYSIS-PATIENTS ,Bioinformatics ,medicine.disease_cause ,Kidney ,ISCHEMIA/REPERFUSION INJURY ,Biochemistry ,3MST ,Nitric oxide ,CBS ,chemistry.chemical_compound ,Mediator ,CYSTATHIONINE-BETA-SYNTHASE ,Internal medicine ,medicine ,Animals ,Humans ,Hydrogen Sulfide ,NITRIC-OXIDE SYNTHASE ,Chemistry ,H2S ,Ischemia-reperfusion ,SODIUM THIOSULFATE ,Kidney disease ,medicine.disease ,equipment and supplies ,Kidney Transplantation ,Transplantation ,(H2S)-PRODUCING ENZYMES ,Endocrinology ,medicine.anatomical_structure ,Renal physiology ,Kidney Diseases ,MERCAPTOPYRUVATE SULFURTRANSFERASE ,Homeostasis ,Oxidative stress - Abstract
Hydrogen sulfide (H2S), the third gasotransmitter, next to nitric oxide and carbon monoxide, is a key mediator in physiology and disease. It is involved in homeostatic functions, such as blood pressure control, electrolyte balance and apoptosis, and regulates pathological mechanisms, including oxidative stress and inflammation. Besides, it is believed to serve as an oxygen sensor under ischemic conditions. The kidney plays a decisive role in many of these processes, indicating an interplay between H2S and renal (patho)physiology. In this review we focus on the (protective) functions of H2S in the kidney. We first discuss endogenous renal H2S production and signaling and elaborate on its regulatory functions in renal physiology. Next, we present data on the role of aberrant H2S levels in the onset and progression of renal disease and suggest the use of H2S metabolites as biomarkers. Finally, we describe that exogenous H2S can protect the kidney against various forms of injury and conclude that modulation of renal H2S levels holds promise for renal patients in the future.
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- 2015
168. Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy
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Harry van Goor, Inge Vreeswijk-Baudoin, Lili Yu, A. Rogier van der Velde, Anne-Roos S. Frenay, Willem P. T. Ruifrok, Rudolf A. de Boer, Natalia López-Andrés, Herman H W Silljé, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), and Cardiovascular Centre (CVC)
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Male ,CHRONIC KIDNEY-DISEASE ,EXPRESSION ,Blood pressure control ,hypertension ,Physiology ,Galectin 3 ,Drug Evaluation, Preclinical ,renin-angiotensin system ,urologic and male genital diseases ,Rats, Sprague-Dawley ,Pathogenesis ,Fibrosis ,Hypertensive Nephropathy ,galectin-3 ,Renin–angiotensin system ,medicine ,Animals ,CONVERTING ENZYME-INHIBITION ,BLOOD-PRESSURE CONTROL ,Renal damage ,business.industry ,CARDIOVASCULAR RISK ,fibrosis ,Amino Sugars ,medicine.disease ,GALECTIN-3/AGE-RECEPTOR-3 KNOCKOUT MICE ,EMERGING ROLE ,CHRONIC HEART-FAILURE ,TGR(mREN)27 ,RENAL-DISEASE ,Galectin-3 ,Immunology ,Kidney Diseases ,business ,chronic kidney disease - Abstract
Galectin-3 activation is involved in the pathogenesis of renal damage and fibrogenesis. Limited data are available to suggest that galectin-3-targeted intervention is a potential therapeutic candidate for the prevention of chronic kidney disease. Homozygous TGR(mREN)27 (REN2) rats develop severe high blood pressure (BP) and hypertensive end-organ damage, including nephropathy and heart failure. Male REN2 rats were treated with N-acetyllactosamine [galectin-3 inhibitor (Gal3i)] for 6 wk; untreated REN2 and Sprague-Dawley rats served as controls. We measured cardiac function with echocardiogram and invasive hemodynamics before termination. BP and proteinuria were measured at baseline and at 3 and 6 wk. Plasma creatinine was determined at 6 wk. Renal damage was assessed for focal glomerular sclerosis, glomerular desmin expression, glomerular and interstitial macrophages, kidney injury molecule-1 expression, and α-smooth muscle actin expression. Inflammatory cytokines and extracellular matrix proteinases were quantified by quantitative real-time PCR. Systolic BP was higher in control REN2 rats, with no effect of Gal3i treatment. Plasma creatinine and proteinuria were significantly increased in control REN2 rats; Gal3i treatment reduced both. Renal damage (focal glomerular sclerosis, desmin, interstitial macrophages, kidney injury molecule-1, α-smooth muscle actin, collagen type I, and collagen type III) was also improved by Gal3i. All inflammatory markers (CD68, IL-68, galectin-3, and monocyte chemoattractant protein-1) were elevated in control REN2 rats and attenuated by Gal3i. Markers of extracellular matrix turnover were marginally altered in untreated REN2 rats compared with Sprague-Dawley rats. In conclusion, galectin-3 inhibition attenuated hypertensive nephropathy, as indicated by reduced proteinuria, improved renal function, and decreased renal damage. Drugs binding to galectin-3 may be therapeutic candidates for the prevention of chronic kidney disease.
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- 2015
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169. International Coordinated Development of Educational Software
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Hasman, A., primary, Donkers, J., additional, Roos, S., additional, Muijtjens, A., additional, Groothedde, R. T., additional, Groothuis, S., additional, de Moor, G., additional, and Klar, R., additional
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- 1990
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170. HBSC 2017. Gezondheid en welzijn van jongeren in Nederland
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Stevens, G.W.J.M., van Dorsselaer, S., Boer, M., de Roos, S., Duinhof, E.L., ter Bogt, T.F.M., van den Eijnden, R.J.J.M., Kuyper, L., Visser, D., Vollebergh, W.A.M., de Looze, M., Stevens, G.W.J.M., van Dorsselaer, S., Boer, M., de Roos, S., Duinhof, E.L., ter Bogt, T.F.M., van den Eijnden, R.J.J.M., Kuyper, L., Visser, D., Vollebergh, W.A.M., and de Looze, M.
- Abstract
Dit rapport bevat de nieuwste resultaten van het Health Behaviour in Schoolaged Children (HBSC) onderzoek in Nederland. Dit is een landelijk representatief onderzoek naar de gezondheid en het welzijn van de schoolgaande jeugd in de leeftijd van 11 tot en met 16. In 2017 is dit onderzoek voor de vijfde keer uitgevoerd in Nederland. Dit rapport beantwoordt vragen zoals: • Hoe gelukkig en gezond zijn jongeren in Nederland anno 2017? Hebben zij veel last van psychische problemen? Bewegen zij genoeg en eten zij gezond? Slapen zij voldoende? • Zijn jongeren tevreden over hun relatie met ouders, vrienden en klasgenoten? Hoe beleven zij school? In hoeverre worden zij gepest? Ervaren zij veel druk door schoolwerk? • Hoeveel roken en drinken zij en hebben zij ooit cannabis, lachgas of XTC gebruikt? Hoe komen zij aan alcohol en aan sigaretten? Hoe streng zijn hun ouders over roken en alcoholgebruik? • Hoeveel jongeren zijn al op jonge leeftijd seksueel actief? Beschermen deze jongeren zich tegen de risico’s van onveilige seks? • Wat is het percentage jongeren dat gedurende de hele dag contact heeft via sociale media? Hoe vaak komt problematisch sociale mediagebruik en gamen eigenlijk voor? • Hoe tolerant zijn jongeren ten opzichte van homoseksualiteit? Hoe denken zij over gelijke rechten van vrouwen en mannen en migranten en niet-migranten? In hoeverre voelen jongeren zich gediscrimineerd op basis van herkomst, geslacht of gezinsinkomen? • Zijn er verschillen in de gezondheid en het welzijn van Nederlandse jongeren naar migratieachtergrond, schoolniveau, gezinswelvaart en gezinsvorm? • Welke veranderingen hebben zich in de afgelopen 16 jaar voorgedaan in de gezondheid en het welzijn van jongeren in Nederland? Het HBSC-onderzoek in Nederland maakt deel uit van een internationaal onderzoek dat iedere vier jaar in meer dan 40 landen plaatsvindt in samenwerking met de
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- 2018
171. Bioengineering of the local wound environment accelerates wound healing by increasing macrophage density and induces a phenotype shift in the wound macrophages
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Öhnstedt, E., Vågesjö, Evelina, Lofton Tomenius, Hava, Roos, S., Phillipson, Mia, Öhnstedt, E., Vågesjö, Evelina, Lofton Tomenius, Hava, Roos, S., and Phillipson, Mia
- Abstract
Meeting Abstract: P023-T
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- 2018
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172. A novel drug-delivery system and drug candidate : using probiotic bacteria as bioreactors for delivery of therapeutic chemokines in wound healing
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Lofton Tomenius, Hava, Vågesjö, Evelina, Öhnstedt, E., Mortier, A., Roos, S., Phillipson, Mia, Lofton Tomenius, Hava, Vågesjö, Evelina, Öhnstedt, E., Mortier, A., Roos, S., and Phillipson, Mia
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Meeting Abstract: P024-T
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- 2018
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173. Facing the rain after the phase out : Performance evaluation of alternative fluorinated and non-fluorinated durable water repellents for outdoor fabrics
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Schellenberger, Steffen, Gillgard, P., Stare, A., Hanning, A., Levenstam, O., Roos, S., Cousins, Ian T., Schellenberger, Steffen, Gillgard, P., Stare, A., Hanning, A., Levenstam, O., Roos, S., and Cousins, Ian T.
- Abstract
Fluorinated durable water repellent (DWR) agents are used to obtain water and stain repellent textiles. Due to the on-going phase-out of DWRs based on side-chain fluorinated polymers (SFP) with long perfluoroalkyl chains, the textile industry lacks suitable alternatives with comparable material characteristics. The constant development and optimization of SFPs for textile applications initiated more than half a century ago has resulted in a robust and very efficient DWR technology and textiles with exceptional hydro- and oleophobic properties. The industry is now in the predicament that the long-chain SFPs with the best technical performance have undesirable toxicological and environmental behavior. This study provides a comprehensive overview of the technical performance of presently available fluorinated and non-fluorinated DWRs as part of a chemical alternatives assessment (CAA). The results are based on a study with synthetic outdoor fabrics treated with alternative DWRs and tested for repellency using industrial standard and complementary methods. Using this approach, the complex structure-property relationships of DWR polymers could be explained on a molecular level. Both short chain SFPs and non-fluorinated DWRs showed excellent water repellency and durability in some cases while short-chain SFPs were more robust of the alternatives to long-chain SFPs. A strong decline in oil repellency and durability with perfluoroalkyl chain length was shown for SFP DWRs. Non-fluorinated alternatives
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- 2018
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174. HBSC 2017. Gezondheid en welzijn van jongeren in Nederland
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Leerstoel Finkenauer, Leerstoel Bogt, Leerstoel Vollebergh, Youth in Changing Cultural Contexts, Stevens, G.W.J.M., van Dorsselaer, S., Boer, M., de Roos, S., Duinhof, E.L., ter Bogt, T.F.M., van den Eijnden, R.J.J.M., Kuyper, L., Visser, D., Vollebergh, W.A.M., de Looze, M., Leerstoel Finkenauer, Leerstoel Bogt, Leerstoel Vollebergh, Youth in Changing Cultural Contexts, Stevens, G.W.J.M., van Dorsselaer, S., Boer, M., de Roos, S., Duinhof, E.L., ter Bogt, T.F.M., van den Eijnden, R.J.J.M., Kuyper, L., Visser, D., Vollebergh, W.A.M., and de Looze, M.
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- 2018
175. A Composite Malicious Peer Eviction Mechanism for Super-P2P Systems
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Ismail, H., Roos, S., Suri, Neeraj, Ismail, H., Roos, S., and Suri, Neeraj
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Large-scale P2P applications (e.g., social networking, online gaming, video streaming) that host millions of users increasingly rely upon semi-structured super-P2P systems to provide efficient services in dynamic environments. Given the critical role of 'super peers' in such topologies, attackers target super peers due to the resultant high damage on P2P services. In this paper, we consider the prominent class of Outgoing Eclipse Attacks (OEA) where an attacker aims to block the communication by controlling all the outgoing connections of honest super peers. Our interest on OEA stems from the fact that our simulation studies reveal that OEAs can cause up to 90% of all service requests to fail. Our attack mitigation relies upon a novel (a) monitoring and (b) malicious peer eviction scheme based on a composite proactive and reactive mechanism. Our proactive mechanism enforces an upper bound on the number of connections an attacker can establish, whereas our reactive mechanism expels malicious peers from the overlay using a distributed consensus protocol. We show that our protection mechanism is highly effective and exhibits a low false-positive rate. Our extensive simulation study validates the analytical results over a large range of parameters with observed detection accuracies of 99% and throughput enhancements of up to 100% while entailing an overhead of less than 5%. © 2018 IEEE.
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- 2018
176. A Detection Mechanism for Internal Attacks on Pull-Based P2P Streaming Systems
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Ismail, H., Roos, S., Suri, Neeraj, Ismail, H., Roos, S., and Suri, Neeraj
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Online streaming is a popular service for data-intensive applications such as video streaming. P2P-based streaming solutions are advocated to help reduce costs for both providers and users. Yet, involving users over data dissemination entails security risks including a variety of denial-of-service attacks. While extensive research exists on mitigating varied attack types, their effectiveness is limited if the attacker can infer information about the topology such as the identity of nodes that have direct connections to the source. The attacker can then leverage the gained insights to place malicious participants in prominent positions. By dropping chunks that should be forwarded, the malicious peers degrade the performance in a stealthy way that does not raise suspicion. We first demonstrate the feasibility of conducting such attacks. Accordingly, we propose a detection mechanism that identifies the attack and removes potential malicious peers from their disruptive positions. We ascertain, theoretically and through simulations, that malicious peers cannot misuse the detection mechanism to gain influence. Our simulation-based study indicates that the proposed detection mechanism is able to detect malicious peers with up to 80-90% accuracy while inducing a small overhead of approximately 8%. © 2018 IEEE.
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- 2018
177. Author Correction: Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Minović, Isidor, Eisenga, Michele F., Riphagen, Ineke J., van den Berg, Else, Kootstra-Ros, Jenny, Frenay, Anne Roos S., van Goor, Harry, Rimbach, Gerald, Esatbeyoglu, Tuba, Levy, Andy P., Gaillard, Carlo A.J.M., Geleijnse, Johanna M., Eggersdorfer, Manfred L., Navis, Gerjan J., Kema, Ido P., Bakker, Stephan J.L., Minović, Isidor, Eisenga, Michele F., Riphagen, Ineke J., van den Berg, Else, Kootstra-Ros, Jenny, Frenay, Anne Roos S., van Goor, Harry, Rimbach, Gerald, Esatbeyoglu, Tuba, Levy, Andy P., Gaillard, Carlo A.J.M., Geleijnse, Johanna M., Eggersdorfer, Manfred L., Navis, Gerjan J., Kema, Ido P., and Bakker, Stephan J.L.
- Abstract
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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- 2018
178. First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients: a propensity-matched survival analysis.
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van Breeschoten, Jesper, Wouters, Michel W. J. M., Hilarius, Doranne L., Haanen, John B., Blank, Christian U., Aarts, Maureen J. B., van den Berkmortel, Franchette W. P. J., de Groot, Jan-Willem B., Hospers, Geke A. P., Kapiteijn, Ellen, Piersma, Djura, van Rijn, Roos S., Suijkerbuijk, Karijn P. M., Blokx, Willeke A. M., Tije, Bert-Jan J. ten, Veldt, Astrid A. M. van der, Vreugdenhil, Art, Boers-Sonderen, Marye J., and van den Eertwegh, Alfonsus J. M.
- Abstract
Background: Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line anti-PD-1 monotherapy vs. BRAF/MEK inhibitors in advanced BRAFV600-mutant melanoma patients.Methods: We selected patients diagnosed between 2014 and 2017 with advanced melanoma and a known BRAFV600-mutation treated with first-line BRAF/MEK inhibitors or anti-PD-1 antibodies, registered in the Dutch Melanoma Treatment Registry. Patients were matched based on their propensity scores using the nearest neighbour and the optimal matching method.Results: Between 2014 and 2017, a total of 330 and 254 advanced melanoma patients received BRAF/MEK inhibitors and anti-PD-1 monotherapy as first-line systemic therapy. In the matched cohort, patients receiving anti-PD-1 antibodies as a first-line treatment had a higher median and 2-year overall survival compared to patients treated with first-line BRAF/MEK inhibitors, 42.3 months (95% CI: 37.3-NE) vs. 19.8 months (95% CI: 16.7-24.3) and 65.4% (95% CI: 58.1-73.6) vs. 41.7% (95% CI: 34.2-51.0).Conclusions: Our data suggest that in the matched BRAFV600-mutant advanced melanoma patients, anti-PD-1 monotherapy is the preferred first-line treatment in patients with relatively favourable patient and tumour characteristics. [ABSTRACT FROM AUTHOR]- Published
- 2021
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179. Search for heavy resonances decaying into WW in the e nu mu nu final state in pp collisions at root s=13 TeV with the ATLAS detector
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Hamiltona, A., Hamano, K., Hamal, P., Hamacher, K., Hallewell, G. D., Halladjian, G., Haley, J., Haleem, M., Hakobyan, H., Hagihara, M., Hageboeck, S., Hadef, A., Haddade, N., Hadavand, H. K., Haber, C., Haas, A., Guzik, M. P., Guyot, C., Gutierrez, P., Gutelman, B. J., Gustavino, G., Gurbuz, S., Gupta, R., Guo, Y., Guo, W., Guo, J., Gumpert, C., Guindon, S., Guillemin, T., Guidoa, E., Gui, B., Gueta, O., Guest, D., Guescinia, F., Guenther, J., Guan, W., Guan, L., Grummer, A., Grossi, G. C., Grosse-Knetter, J., Gross, E., Groh, S., Grivaz, J. -F., Gris, Ph., Grinstein, S., Grillo, A. A., Griffiths, J., Grevtsov, K., Grenier, P., Gregor, I. M., Grefe, C., Greenwood, Z. D., Gray, H. M., Gravila, P. M., Gratchev, V., Grancagnolo, S., Gramstad, E., Gramling, J., Gradin, P. O. J., Grabowska-Bold, I., Gozani, E., Goy, C., Govender, N., Goussiou, A. G., Goujdami, D., Goudet, C. R., Gottardo, C. A., Gostkin, M. I., Gossling, C., Goshaw, A. T., Gorisek, A., Gorini, E., Gorini, B., Gordon, H. 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A., Schwemling, Ph., Schwienhorst, R., Schwindling, J., Sciandra, A., Sciolla, G., Scornajenghi, M., Scuri, F., Scutti, F., Searcy, J., Seema, P., Seidel, S. C., Seiden, A., Seixas, J. M., Sekhniaidze, G., Sekhon, K., Sekula, S. J., Semprini-Cesari, N., Senkin, S., Serfon, C., Serin, L., Serkin, L., Sessa, M., Seuster, R., Severini, H., Sfiligoj, T., Sforza, F., Sfyrla, A., Shabalina, E., Shaikh, N. W., Shan, L. Y., Shang, R., Shank, J. T., Shapiro, M., Shatalov, P. B., Shaw, K., Shcherbakova, A., Shen, Y., Sherafati, N., Sherman, A. D., Shi, L., Shimizu, S., Shimmin, C. O., Shimojima, M., Shirabe, S., Shiyakova, M., Shlomi, J., Shmeleva, A., Saadi, D. Shoaleh, Shochet, M. J., Shojaii, S., Shope, D. R., Shrestha, S., Shulga, E., Shupe, M. A., Sicho, P., Sickles, A. M., Sidebo, P. E., Haddad, E. Sideras, Sidiropoulou, O., Sidoti, A., Siegert, F., Sijacki, Dj., Silva, J., Silva, M., Silverstein, S. B., Simak, V., Simic, L., Simion, S., Simioni, E., Simon, M., Sinervo, P., Sinev, N. B., Sioli, M., Siragusa, G., Siral, I., Sivoklokov, S. Yu., Sjolin, J., Skubic, P., Slavicek, T., Kourkoumelis, C., Kouskoura, V., Kowalewska, A. B., Slawinska, M., Sliwa, K., Slovak, R., Smakhtin, V., Smart, B. H., Smiesko, J., Smirnov, N., Smirnov, S. Yu., Smirnov, Y., Smirnova, L. N., Smirnova, O., Smith, J. W., Smith, M. N. K., Smith, R. W., Smolek, K., Snesarev, A. A., Snyder, I. M., Snyder, S., Sobie, R., Socher, F., Soffer, A., Soh, D. A., Sokhrannyi, G., Sanchez, C. A. Solans, Solar, M., Kowalewski, R., Kowalski, T. Z., Kozakai, C., Kozanecki, W., Kozhin, A. S., Kramarenko, V. A., Kramberger, G., Krasnopevtsev, D., Krasny, M. W., Krasznahorkay, A., Krauss, D., Soldatov, E. Yu., Soldevila, U., Solodkov, A. A., Soloshenko, A., Kremer, J. A., Solovyanov, O. V., Solovyev, V., Song, H., Sopczak, A., Sosa, D., Sotiropoulou, C. L., Sottocornola, S., Kreutzfeldt, K., Kluth, S., Kluit, P., Kluge, E. -E., Klitzner, F. F., Klioutchnikova, T., Klingl, T., Klingenberg, R., Klimentov, A., Klimek, P., Kleinknecht, K., Klein, M. H., Klapdor-Kleingrothaus, T., Kladiva, E., Kivernyk, O., Kitali, V., Kisielewska, D., Kishimoto, T., Kiryunin, A. E., Kirchmeier, D., Kind, O. M., Kimura, N., Kim, Y. K., Kim, S. H., Kim, H. Y., Kido, S., Khubua, J., Khramov, E., Khovanskiy, V., Khoo, T. J., Khodinov, A., Kharlamova, T., Kharlamov, A. G., Khanov, A., Khalil-zada, F., Khader, M., Keyes, R. A., Kersten, S., Kersevan, B. P., Kepka, O., Keoshkerian, H., Kellermann, E., Keller, J. S., Kehoe, R., Keeler, R., Kazanin, V. F., Kawamura, G., Kawamoto, T., Kawagoe, K., Kawade, K., Katzy, J., Katre, A., Kato, C., Kataoka, Y., Kastanas, A., Kass, R. D., Kashif, L., Kasahara, K., Karyukhin, A. N., Karpova, Z. M., Karpov, S. N., Karentzos, E., Kareem, M. J., Karastathis, N., Karakostas, K., Kar, D., Kaplan, L. S., Kaplan, B., Kanzaki, J., Kantserov, V. A., Kanjir, L., Kanaya, N., Kamenshchikov, A., Kama, S., Kaluza, A., Kalderon, C. W., Kajomovitz, E., Kaji, T., Kahn, S. J., Kagan, M., Kagan, H., Kado, M., Kaczmarska, A., Kohler, M. K., Juste Rozas, A., Ju, X., Jovicevic, J., Jorge, P. M., Jongmanns, J., Jones, S., Jon-And, K., Johnson, W. J., Johnson, C. A., Johns, K. A., Jivan, H., Jinnouchi, O., Jinaru, A., Jin, S., Pena, J. Jimenez, Jiang, Z., Jiang, Y., Jiang, H., Jia, J., Ji, H., Jezequel, S., Jenni, P., Jejelava, J., Jeanty, L., Jeanneau, F., Javurkova, M., Javurek, T., Javadov, N., Jarlskog, G., Janus, P. A., Janus, M., Janssen, J., Jansky, R., Jana, D. K., Jamin, D. O., Jakoubek, T., Jakobsen, S., Jakobs, K., Jakobi, K. B., Jain, V., Jacobs, R. M., Jackson, P., Jabbar, S., Izzo, V., Izen, J. M., Iwasaki, H., Iuppa, R., Ponce, J. M. Iturbe, Ito, F., Istin, S., Ishitsuka, M., Ishino, M., Ishijima, N., Isacson, M. F., Ippolito, V., Iordanidou, K., Iodice, M., Ioannou, P., Introzzi, G., Iltzsche, F., Ilic, N., Iliadis, D., Ilchenko, Y., Ikeno, M., Ikegami, Y., Iizawa, T., Igonkina, O., Iengo, P., Idrissi, Z., Iconomidou-Fayard, L., Ibragimov, I., Iakovidis, G., Iacobucci, G., Hyneman, R., Huth, J., Huston, J., Huseynov, N., Huo, P., Hunter, R. F. H., Huhtinen, M., Hughes, E. W., Huegging, F., Hubaut, F., Hubacek, Z., Huang, Y., Huc, S., Hu, Q., Hsu, S. -C., Hsu, P. J., Hrynevich, A., Hryn'ova, T., Hrivnac, J., Hristova, I., Hrdinka, J., Hrabovsky, M., Hoya, J., Hoummadaa, A., Hou, S., Hostiuc, A., Hostachy, J-Y., Horton, A. J., Horii, Y., Hopkins, W. H., Hooberman, B. H., Hong, T. M., Honda, T., Honda, S., Homann, M., Holzbock, M., Holmes, T. R., Hohn, D., Hoenig, F., Hoeferkamp, M. R., Hoecker, A., Hod, N., Hobbs, J., Hlaluku, D. R., Hladik, O., Hiti, B., Hirschbuehl, D., Hirose, M., Hinchliffe, I., Hils, M., Hiller, K. H., Hill, E., Hildebrand, K., Higon-Rodriguez, E., Higashino, S., Hetherly, J. W., Hessey, N. P., Herwig, T. C., Hervas, L., Hertenberger, R., Herten, G., Herr, H., Jimenez, Y. Hernandez, Herget, V., Herde, H., Herbert, G. H., Henrot-Versille, S., Correia, A. M. Henriques, Henkelmann, S., Heng, Y., Helsens, C., Hellman, S., Held, A., Helary, L., Hejbal, J., Heinz, C., Heinrich, L., Heinrich, J. J., Heinemann, B., Heim, T., Heim, S., Heidegger, K. K., Heer, S., Heelan, L., Hedberg, V., Heck, T., Hayden, D., Hawkings, R. J., Havranek, M., Havener, L. B., Hauswald, L., Hauser, R., Haug, S., Hassani, S., Hasegawa, Y., Hartmann, N. M., Harkusha, S., Hariri, F., Harenberg, T., Hard, A. S., Hara, K., Hansen, P. H., Hansen, M. C., Hansen, J. D., Hansen, J. B., Hanke, P., Haney, B., Handl, D. M., Hance, M., Hanawa, K., Hanagaki, K., Hana, S., Hana, K., Hamnett, P. G., Luminari, L., Lund-Jensen, B., Lutz, M. S., Luzi, P. M., Lynn, D., Lysak, R., Lytken, E., Lyu, F., Lyubushkin, V., Ma, H., Ma, L. L., Ma, Y., Maccarrone, G., Macchiolo, A., Macek, B., Miguens, J. Machado, Madaffari, D., Madar, R., Mader, W. F., Madsen, A., Madysa, N., Maeda, J., Maeland, S., Maeno, T., Maevskiy, A. S., Magerl, V., Maiani, C., Maidantchik, C., Maier, T., Maio, A., Majersky, O., Majewski, S., Makida, Y., Makovec, N., Malaescu, B., Malecki, Pa., Maleev, V. P., Malek, F., Mallik, U., Malon, D., Maltezos, S., Malone, C., Malyukov, S., Mamuzic, J., Mancini, G., Mandic, I., Maneira, J., Manhaes de Andrade Filho, L., Ramos, J. Manjarres, Mankinen, K. H., Mann, A., Manousos, A., Mansoulie, B., Mansour, J. D., Mantifel, R., Mantoani, M., Manzoni, S., Mapelli, L., Marceca, G., March, L., Marchiori, G., Marcisovsky, M., Tobon, C. A. Marin, Marjanovic, M., Marley, D. E., Love, J., Lu, H., Lu, N., Lu, Y. J., Lubatti, H. J., Luci, C., Lucotte, A., Luedtke, C., Luehring, F., Lukas, W., Muenstermann, D., Moss, H. J., Morris, J. D., Miyagawa, P. S., Mills, C., Millar, D. A., Mijovic, L., Middleton, R. P., Miano, F., Meng, L., Menary, S. B., Mehta, A., McNicol, C. J., McMahon, S. J., McClymont, L. I., Maxfield, S. J., Masik, J., Martyniuk, A. C., Martin-Haugh, S., Martin, V. J., Martin, T. A., Kirk, J., Marsden, S. P., Marchese, L., Macdonald, C. M., Klein, M., Klein, U., Konstantinidis, N., Korn, A., Love, P. A., Long, R. E., Lohwasser, K., Loebinger, F. K., Allport, P. P., Liu, J. K. K., Alshehri, A. A., Korolkova, E. V., Lin, C. Y., Lewis, D., Levy, M., Lester, C. G., Lerner, G., Leonidopoulos, C., Leney, K. J. C., Laycock, P., Lack, D. P. J., Kyriazopoulos, D., Kretzschmar, J., Kourlitis, E., Anastopoulos, C., Andari, N., Anders, J. K., Armitage, L. J., Arratia, M., Artoni, G., Asquith, L., Baca, M. J., Backes, M., Baines, J. T., Barlow, N., Barnett, B. M., Barr, A. J., Barton, A. E., Bates, R. L., Batley, J. R., Beattie, M. D., Becker, K., Bell, A. S., Beresford, L., Berry, T., Bertram, I. A., Bethani, A., Bevan, A. J., Bielski, R., Blue, A., Boisvert, V., Bona, M., Borissov, G., Bortoletto, D., Bouhova-Thacker, E. V., Boutle, S. K., Bozson, A. J., Bracinik, J., Madden, W. D. Breaden, Briglin, D. L., Bristow, T. M., Britton, D., Brochu, F. M., Brooks, T., Broughton, J. H., Brunt, B. H., Buckley, A. G., Burdin, S., Burke, S., Burr, J. T. P., Bussey, P., Buttar, C. M., Butterworth, J. M., Campanelli, M., Casadei, D., Cerri, A., Chapman, J. D., Charlton, D. G., Chavez Barajas, C. A., Christodoulou, V., Clark, P. J., Connelly, I. A., Cooper-Sarkar, A. M., Costanzo, D., Cottin, G., Cowan, G., Cox, B. E., Crawley, S. J., Cuhadar Donszelmann, T., D'Auria, S., D'Onofrio, M., Da Via, C., Daniells, A. C., Dann, N. S., Davison, P., Dawson, I., De Santo, A., Dervan, P., Dewhurst, A., Dopke, J., Doyle, A. T., Duncan, A. K., Emeliyanov, D., Ennis, J. S., Facini, G., Falla, R. J., Farrington, S. M., Giannelli, M. Faucci, Fawcett, W. J., Fenton, M. J., Forcolin, G. T., Forti, A., Foster, A. G., Fox, H., Fracchia, S., Freeborn, D., Frost, J. A., Gadomski, S., Gallas, E. J., Gallop, B. J., Gao, Y., Gee, C. N. P., George, S., Gibson, S. M., Giuli, F., Gonella, L., Gonnella, F., Graham, E. C., Gray, C., Gregersen, K., Grimm, K., Grout, Z. J., Gul, U., Ortiz, N. G. Gutierrez, Gutschow, C., Gwenlan, C., Gwilliam, C. B., Hamity, G. N., Han, L., Harrison, P. F., Hasib, A., Hawkes, C. M., Thomas, J. P., Taylor, A. J., Tahirovic, E., Sutton, M. R., Suruliz, K., Strubig, A., Stewart, G. A., Denis, R. D. St., Spangenberg, M., Sowden, B. C., Song, W., Sommer, P., Sogaard, A., Smizanska, M., Slater, M., Jiggins, S., Skinner, M. B., Simmons, B., Shipsey, I. P. J., Sherwood, P., Shehu, C. Y., Shaw, S. M., Schweiger, H., Johansson, P., Scanlon, T., Sawyer, C., Savage, G., Castillo, I. Santoyo, Jones, R. W. L., Jones, S. D., Jones, T. J., Kartvelishvili, V., Sankey, D. P. C., Kay, E. F., Salvatore, F., Rompotis, N., Robson, A., Kempster, J. J., Robinson, D., Roberts, R. T., Rizvi, E., Richter, S., Reynolds, E., Rawling, J. H., Kendrick, J., Raine, J. A., Radescu, V., Quilty, D., Kilby, C. R., Qin, Y., Price, D., Pollard, C. S., Pilkington, A. D., Pickering, M. A., Pianori, E., Phillips, P. W., Petrov, M., Peters, R. F. Y., Pater, J. R., Pastore, Fr., Parker, M. A., Parker, A. J., Vazquez, J. G. Panduro, Owen, R. E., Owen, M., Oh, A., O'Shea, V., Nurse, E., Norjoharuddeen, N., Nikolopoulos, K., Nickerson, R. B., Newman, P. R., Nelson, M. E., Nagai, K., Mwewa, C., Murray, W. J., King, B. T., Sanchez, F. J. Munoz, Mullen, P., Hays, C. P., Hays, J. M., Hayward, H. S., Haywood, S. J., Henderson, R. C. W., Hesketh, G. G., Hill, J. C., Hillier, S. J., Hoad, X., Hodgkinson, M. C., Hodgson, P., Howarth, J., Huffman, T. B., Issever, C., Abraham, N. L., Zemaityte, G., Yusuff, I., Wynne, B. M., Wyatt, T. R., Worm, S. D., Winston, O. J., Winkels, E., Wilson, J. A., Wilk, F., Wielers, M., Jelinskas, A., Wickens, F. J., Adye, T., Allbrooke, B. M. M., Jeske, C., Whitmore, B. W., Wharton, A. M., Weidberg, A. R., Waugh, B. M., Watts, S., Watson, M. F., Watson, A. T., Watkins, P. M., Washbrook, A., Wardrope, D. R., Ward, C. P., Walder, J., Vivarelli, I., Vigani, L., Viehhauser, G. H. A., Boeriu, O. E. Vickey, Vickey, T., Vaidya, A., Tseng, J. C. -L., Tresoldi, F., Tovey, D. R., Tomlinson, L., Thompson, A. S., Thompson, P. D., Thomas-Wilsker, J., and Teixeira-Dias, P.
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Science & Technology ,High Energy Physics::Lattice ,Physics ,High Energy Physics::Phenomenology ,STANDARD MODEL ,HIGGS BOSONS ,MASS ,Nuclear & Particles Physics ,Physics, Particles & Fields ,0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics ,Physical Sciences ,GLUON FUSION ,High Energy Physics::Experiment ,LHC ,Nuclear Experiment ,PARTICLE ,0206 Quantum Physics - Abstract
A search for neutral heavy resonances is performed in the WW→eνμνWW→eνμν decay channel using pp collision data corresponding to an integrated luminosity of 36.1fb−136.1fb−1, collected at a centre-of-mass energy of 13 TeVTeV by the ATLAS detector at the Large Hadron Collider. No evidence of such heavy resonances is found. In the search for production via the quark–antiquark annihilation or gluon–gluon fusion process, upper limits on σX×B(X→WW)σX×B(X→WW) as a function of the resonance mass are obtained in the mass range between 200 GeVGeV and up to 5 TeVTeV for various benchmark models: a Higgs-like scalar in different width scenarios, a two-Higgs-doublet model, a heavy vector triplet model, and a warped extra dimensions model. In the vector-boson fusion process, constraints are also obtained on these resonances, as well as on a Higgs boson in the Georgi–Machacek model and a heavy tensor particle coupling only to gauge bosons.
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- 2017
180. Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Manfred Eggersdorfer, Andrew P. Levy, Anne-Roos S. Frenay, Jenny E. Kootstra-Ros, Gerjan Navis, Harry van Goor, Tuba Esatbeyoglu, Isidor Minović, Ineke J. Riphagen, Ido P. Kema, Stephan J. L. Bakker, Gerald Rimbach, Michele F Eisenga, Else van den Berg, Carlo A. J. M. Gaillard, Johanna M. Geleijnse, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Value, Affordability and Sustainability (VALUE), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
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medicine.medical_specialty ,INTERLEUKIN-6 ,Nutrition and Disease ,lcsh:Medicine ,PROTEIN ,030204 cardiovascular system & hematology ,Gastroenterology ,Article ,MULTIPLE IMPUTATION ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,MISSING DATA ,Interquartile range ,Internal medicine ,Voeding en Ziekte ,Life Science ,Medicine ,030212 general & internal medicine ,lcsh:Science ,Interleukin 6 ,Prospective cohort study ,Kidney transplantation ,VLAG ,RISK ,INSULIN-RESISTANCE ,Multidisciplinary ,biology ,business.industry ,MORTALITY ,lcsh:R ,Haptoglobin ,Acute-phase protein ,medicine.disease ,PERFORMANCE LIQUID-CHROMATOGRAPHY ,Endocrinology ,OBESITY ,MARKER ,biology.protein ,lcsh:Q ,Metabolic syndrome ,business - Abstract
Haptoglobin (Hp) is an acute phase protein that has recently been linked to components of the metabolic syndrome (MetS). We aimed to evaluate Hp as marker of MetS, and to assess its association with long-term outcome in renal transplant recipients (RTR). We measured plasma Hp in a prospective cohort of 699 stable RTR and 149 healthy controls. Median plasma Hp concentration in RTR was 1.4 [interquartile range (IQR), 1.0–1.8] g/L, which was higher compared to 1.1 [0.9–1.4] g/L in controls (P
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- 2017
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181. Eigenvalue pinching on spinc manifolds
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Roos, S.
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- 2017
182. Determination of process parameters for the integrated countercurrent chromatography (iCCC)
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Mestmäcker, F., primary, Zobel-Roos, S., additional, and Strube, J., additional
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- 2018
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183. Author Correction: Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Minović, Isidor, primary, Eisenga, Michele F., additional, Riphagen, Ineke J., additional, van den Berg, Else, additional, Kootstra-Ros, Jenny, additional, Frenay, Anne-Roos S., additional, van Goor, Harry, additional, Rimbach, Gerald, additional, Esatbeyoglu, Tuba, additional, Levy, Andy P., additional, Gaillard, Carlo A. J. M., additional, Geleijnse, Johanna M., additional, Eggersdorfer, Manfred L., additional, Navis, Gerjan J., additional, Kema, Ido P., additional, and Bakker, Stephan J. L., additional
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- 2018
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184. Platelet-derived Growth Factor Receptor- β Function in Anaplastic Large Cell Lymphoma
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Roos, S., primary, Garces de los Fayos Alonso, I., additional, Schlederer, M., additional, Kothmayer, M., additional, Wodarz, G., additional, Pusch, O., additional, Lagger, S., additional, and Kenner, L., additional
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- 2018
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185. Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin
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Rolf A.K. Stahl, Sascha Lange, Natalia Alenina, Anne-Roos S. Frenay, Harry van Goor, Genevieve Nguyen, Michael Bader, A.H. Jan Danser, Edzard Schwedhelm, Ulrich Wenzel, Christoph Fraune, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), and Internal Medicine
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medicine.medical_specialty ,kidney ,Physiology ,INCREASES ,BLOCKADE ,INHIBITION ,BLOOD-PRESSURE ,Pharmacology ,RATS ,chemistry.chemical_compound ,DOUBLE-BLIND ,Fumarates ,Internal medicine ,Renin–angiotensin system ,Internal Medicine ,medicine ,Animals ,Humans ,Receptor ,Antihypertensive Agents ,Mice, Knockout ,Kidney ,biology ,business.industry ,PROSEGMENT ,Angiotensin-converting enzyme ,(pro)renin receptor ,Aliskiren ,Angiotensin II ,Amides ,Immunohistochemistry ,Blockade ,Mice, Inbred C57BL ,ANGIOTENSIN-II ,MICE ,Blood pressure ,Endocrinology ,medicine.anatomical_structure ,chemistry ,handle region peptide ,renin ,biology.protein ,Cardiology and Cardiovascular Medicine ,business ,aliskiren ,Protein Binding - Abstract
Background and objective: The antihypertensive effects of the direct renin inhibitor aliskiren last substantially longer after treatment withdrawal than expected based upon its plasma half-life. This may be attributable to drug accumulation in the kidney as recently shown in rats and mice. Since aliskiren binds to renin we examined in the present study whether this accumulation depends on the renin content of the kidney.Methods: For this we measured the aliskiren concentration in the kidney of wild-type as well as AT1a receptor(-/-) and Ren1c(-/-) mice. AT1a receptor(-/-) mice overexpress renin due to the lack of angiotensin II-mediated negative feedback, whereas Ren1c(-/-) mice lack renal renin expression.Results: Accumulation of aliskiren was found in the kidney of wild-type mice. However, renal accumulation was neither influenced by the overexpression nor by the absence of renin in the kidney. It was recently shown that the effects of aliskiren can be blocked by a handle region peptide, which inhibits the nonproteolytic activation of prorenin bound to the (pro)renin receptor. To investigate whether this putative (pro)renin receptor blocker influences renal aliskiren accumulation, we administered the blocker in addition to aliskiren. No influence on renal aliskiren accumulation was observed.Conclusion: These data confirm accumulation of aliskiren in the murine kidney and demonstrate that neither renin nor (pro)renin receptor-bound prorenin are major players in this process.
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- 2013
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186. Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Minović, Isidor, Eisenga, Michele F., Riphagen, Ineke J., Berg, Else, van den, Kootstra-Ros, Jenny E., Frenay, Anne-Roos S., Goor, Harry, van, Rimbach, Gerald, Esatbeyoglu, Tuba, Levy, Andy P., Ajm Gaillard, Carlo, Geleijnse, Johanna M., Eggersdorfer, Manfred L., Navis, Gerjan J., Kema, Ido P., Bakker, Stephan L.J., Minović, Isidor, Eisenga, Michele F., Riphagen, Ineke J., Berg, Else, van den, Kootstra-Ros, Jenny E., Frenay, Anne-Roos S., Goor, Harry, van, Rimbach, Gerald, Esatbeyoglu, Tuba, Levy, Andy P., Ajm Gaillard, Carlo, Geleijnse, Johanna M., Eggersdorfer, Manfred L., Navis, Gerjan J., Kema, Ido P., and Bakker, Stephan L.J.
- Abstract
Haptoglobin (Hp) is an acute phase protein that has recently been linked to components of the metabolic syndrome (MetS). We aimed to evaluate Hp as marker of MetS, and to assess its association with long-term outcome in renal transplant recipients (RTR). We measured plasma Hp in a prospective cohort of 699 stable RTR and 149 healthy controls. Median plasma Hp concentration in RTR was 1.4 [interquartile range (IQR), 1.0-1.8] g/L, which was higher compared to 1.1 [0.9-1.4] g/L in controls (P < 0.001). Hp was independently associated with the MetS (β = 0.10) (P = 0.005). During follow-up of 5.4 [4.8-6.1] years, 150 (21%) recipients died, of whom 60 (9%) due to cardiovascular causes, and 83 (12%) RTR developed graft failure. High (≥2.0 g/L) and low (≤0.9 g/L) plasma Hp were associated with increased risk of mortality (HR's 2.3 [1.3-4.1] and 1.9 [1.0-3.5], resp.), predominantly cardiovascular. The association of high Hp lost significance upon adjustment for inflammation markers (HR 1.5 [0.8-2.7]), while low Hp was independently associated with mortality (HR 2.2 [1.2-4.0]). Hp was not associated with graft failure (P = 0.49). In conclusion, plasma Hp is independently associated with MetS in RTR. Importantly, high and low Hp are associated with increased mortality risk, independent of MetS.
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- 2017
187. Effect of contour bunds on surface runoff and soil erosion in the Bokole watershed, Southwest Ethiopia
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Roos, S. de, van Beek, dr. L.P.H. (Thesis Advisor), Roos, S. de, and van Beek, dr. L.P.H. (Thesis Advisor)
- Abstract
Soil erosion belongs to one of the most severe environmental problems in Ethiopia. Particularly in the highlands, land degradation by soil erosion is a concerning issue, due to steep slopes and high intensity rainfall. This while, according to the FAO, nearly all of the national agricultural and economic activity is derived from the highlands. Soil losses on the cultivated highlands were estimated by Hurni around 42 ton/ha/yr. To improve the economic growth of Ethiopia and reduce the threat of land degradation, several soil and water conservation (SWC) measures have been introduced over the years, one of which are contour bunds. Studies show that contour soil and stone bunds have positive effects on soil loss reduction and yield increase. The majority of this research however, is completed in the northern highlands. In this study, the focus lies on the effectiveness of contour bunds as a soil water conservation measure in agricultural fields in the Bokole watershed, situated in Southwest Ethiopia. Two experimental fields covered with maize crops were studied during a field work between August and September 2016, but only one of these fields was sufficient for erosion and runoff assessment. Both fields were divided into six adjacent plots with total lengths of around 18 to 20 metres and variating widths of around 6 to 10 metres. Each field contained four plots with soil bunds, dividing the plots into an upper (A) and lower (B) section and two plots served as control plots, containing no bunds. On the control plots sediment concentrations were measured. Erosion was assessed on each plot for field 2 with the Assessment of Current Erosion Damage (ACED) method. An additional field with of 1000 m2 (20m x 50m) was used to assess erosion on land with contour stone bunds. Runoff and erosion was modelled with the rMMF method. To include the effect of bunds on runoff, an adapted version of the rMMF model was used. The lower plots (B-plots) of the experimental field were more v
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- 2017
188. A randomized controlled trial of Internet-Based Cognitive Behavior Therapy for perfectionism including an investigation of outcome predictors
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Rozental, A., Shafran, R., Wade, T., Egan, Sarah, Nordgren, L., Carlbring, P., Landström, A., Roos, S., Skoglund, M., Thelander, E., Trosell, L., Örtenholm, A., Andersson, G., Rozental, A., Shafran, R., Wade, T., Egan, Sarah, Nordgren, L., Carlbring, P., Landström, A., Roos, S., Skoglund, M., Thelander, E., Trosell, L., Örtenholm, A., and Andersson, G.
- Abstract
© 2017 Elsevier LtdBeing highly attentive to details can be a positive feature. However, for some individuals, perfectionism can lead to distress and is associated with many psychiatric disorders. Cognitive behavior therapy has been shown to yield many benefits for those experiencing problems with perfectionism, but the access to evidence-based care is limited. The current study investigated the efficacy of guided Internet-based Cognitive Behavior Therapy (ICBT) and predictors of treatment outcome. In total, 156 individuals were included and randomized to an eight-week treatment or wait-list control. Self-report measures of perfectionism, depression, anxiety, self-criticism, self-compassion, and quality of life were distributed during screening and at post-treatment. Intention-to-treat were used for all statistical analyses. Moderate to large between-group effect sizes were obtained for the primary outcome measures, Frost Multidimensional Perfectionism Scale, subscales Concerns over Mistakes and Personal Standards, Cohen's d = 0.68–1.00, 95% Confidence Interval (CI) [0.36–1.33], with 35 (44.9%) of the patients in treatment being improved. Predictors were also explored, but none were related to treatment outcome. In sum, guided ICBT can be helpful for addressing problems with clinical perfectionism, but research of its long-term benefits is warranted.
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- 2017
189. Surgical Outcome after Penile Inversion Vaginoplasty: A Retrospective Study of 475 Transgender Women
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Birgit I. Witte, Roos S. D. van der Pas, Jan Maerten Smit, Wouter B. van der Sluis, Margriet G. Mullender, Müjde Özer, Marlon E. Buncamper, Mark-Bram Bouman, Plastic, Reconstructive and Hand Surgery, Other Research, Epidemiology and Data Science, and EMGO - Quality of care
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medicine.medical_specialty ,business.industry ,Gold standard ,030232 urology & nephrology ,Follow up studies ,Retrospective cohort study ,Skin transplantation ,Transgender women ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Vaginoplasty ,Vaginal construction ,Stage (cooking) ,business - Abstract
Background:For many transgender women, vaginoplasty is the final stage in the gender-confirming process. Penile inversion vaginoplasty is considered the gold standard for vaginal construction in transgender women. In this study, the authors assessed intraoperative and postoperative complications aft
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- 2016
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190. Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients
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Matthias Bachtler, Martin H. de Borst, Martin Feelisch, Stephan J. L. Bakker, Else van den Berg, Harry van Goor, Andreas Pasch, Nadine Tschopp, Charlotte A. Keyzer, Anne-Roos S. Frenay, Lifestyle Medicine (LM), Groningen Kidney Center (GKC), and Groningen Institute for Organ Transplantation (GIOT)
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0301 basic medicine ,Graft Rejection ,Male ,IMPACT ,BLOOD-PRESSURE ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Biochemistry ,Gastroenterology ,Body Mass Index ,Kidney transplantation ,chemistry.chemical_compound ,0302 clinical medicine ,Natriuretic Peptide, Brain ,Free thiols ,Graft Survival ,Middle Aged ,Cardiovascular disease ,THIOLS ,Cardiovascular Diseases ,CARDIOVASCULAR-DISEASE ,ACID ,Female ,Graft failure ,Glomerular Filtration Rate ,Adult ,medicine.medical_specialty ,KIDNEY-TRANSPLANTATION ,Thiosulfates ,Renal function ,Nitric oxide ,MECHANISMS ,03 medical and health sciences ,Sex Factors ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Sulfhydryl Compounds ,Aged ,Proportional Hazards Models ,Glycated Hemoglobin ,NITRIC-OXIDE ,business.industry ,Proportional hazards model ,MORTALITY ,medicine.disease ,Peptide Fragments ,Surgery ,030104 developmental biology ,Blood pressure ,chemistry ,Oxidative stress ,Multivariate Analysis ,Graft survival ,Calcium ,business ,Body mass index ,Biomarkers - Abstract
Oxidative stress contributes significantly to graft failure, morbidity and mortality in renal transplant recipients (RTR). In cells, free sulfhydryl groups (reduced thiols, R-SH) are the transducers of redoxregulated events; their oxidation status is modulated by interaction with reactive oxygen and nitrogen oxide species and thought to be in equilibrium with the circulating pool. We hypothesized that high levels of serum free thiols are a reflection of a favorable redox status and therefore positively associated with cardiovascular risk parameters, patient and graft survival in RTR.To test this, reactive free thiol groups (R-SH; corrected for total protein) were quantified in serum of 695 RTR (57% male, 53 +/- 13 yr, functioning graft >= 1 yr) using Ellman's Reagent, and R-SH determinants were evaluated with multivariable linear regression models. Associations between R-SH and mortality or graft failure were assessed using multivariable Cox regression analyses.In multivariable models, male gender, estimated glomerular filtration rate and serum thiosulfate positively associated with R-SH while BMI, HbAl c, corrected calcium and NT-pro-BNP inversely associated with R-SH (model R-2=0.26). During follow-up (3.1 [2.7-3.9] yrs), 79 (11%) patients died and 45 (7%) patients developed graft failure. R-SH correlated inversely with all-cause mortality (HR 0.58 [95% CI 0.45-0.75] per SD increase) and graft failure (HR 0.42 [0.30-0.59]; both P Serum R-SH are associated with a beneficial cardiovascular risk profile and better patient and graft survival in RTR, suggesting potential usefulness as low-cost, high-throughput screening tool for whole body redox status in translational studies. Whether R-SH modification improves long-term outcome of RTR warrants further exploration. (C) 2016 Elsevier Inc. All rights reserved.
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- 2016
191. STUDENT’S SOFT SKILL ACQUISITION IN AN OUTDOOR ADVENTURE EDUCATION EVENT OVER TWO YEARS OF PARTICIPATION
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ROOS, S. J., LENNOX, A., BOTHA-RAVYSE, C., 10897143 - Botha-Ravyse, Chrisna Rachél, 11715472 - Lennox, Anita, and 12530182 - Roos, Stephanus Johannes
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lcsh:Social Sciences ,lcsh:H ,Students,soft skills,adventure education,OAE,recreation ,adventure education ,lcsh:AZ20-999 ,ComputingMilieux_COMPUTERSANDEDUCATION ,lcsh:H1-99 ,recreation ,lcsh:Social sciences (General) ,Students ,lcsh:History of scholarship and learning. The humanities ,soft skills ,OAE - Abstract
Outdoor Adventure Education can be used to develop and hone the transferable orso called soft skills such as group work and problem-solving skills in highereducation. These skills are also much needed to ensure employability. An outdooradventure activity was developed and implemented by lecturers in order to bridgethis gap between university and the industry in order to hone the transferableskills of students studying sport and recreation. Data were collected over twoyears. Two hundred students participated in the research study with a mean age of22±4 years. Data were collected qualitatively and analysed and subsequentlynumerically coded to ensure statistical analyses. Analyses indicated no statisticaldifferences between skills learned in the first and second year. Students were thendivided into first time and second time participants and statistical differences werefound. The second time participants reported mostly on leadership skills learnedand first time participants on teamwork. Implementingan outdoor AdventureEducation event was effective in developing skills in students much needed for success in higher education as well as becoming well-rounded individuals whompossess all the qualities for rewarding employment.
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- 2016
192. Serum free thiols in chronic heart failure
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Wouter C. Meijers, Anne-Roos S. Frenay, Marinda M. Dekker, Harry van Goor, Andreas Pasch, Henri G. D. Leuvenink, Anne M. Koning, Martin Feelisch, Rudolf A. de Boer, Groningen Institute for Organ Transplantation (GIOT), Cardiovascular Centre (CVC), and Groningen Kidney Center (GKC)
- Subjects
0301 basic medicine ,Male ,Pathology ,Antioxidant ,FREE-RADICALS ,Survival ,medicine.medical_treatment ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,medicine.disease_cause ,REDOX STATUS ,Gastroenterology ,Severity of Illness Index ,DISEASE ,chemistry.chemical_compound ,0302 clinical medicine ,ANTIOXIDANT ,Natriuretic Peptide, Brain ,HUMAN PLASMA ,Prospective cohort study ,chemistry.chemical_classification ,Ejection fraction ,ASSOCIATION ,Middle Aged ,Prognosis ,EUROPEAN-SOCIETY ,Rehospitalisation ,Thiol ,Female ,medicine.medical_specialty ,Renal function ,DIAGNOSIS ,03 medical and health sciences ,Thiols ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Sulfhydryl Compounds ,Aged ,Pharmacology ,Heart Failure ,Cholesterol ,business.industry ,medicine.disease ,Chronic heart failure ,Peptide Fragments ,030104 developmental biology ,chemistry ,Oxidative stress ,Heart failure ,Chronic Disease ,business ,Biomarkers ,TASK-FORCE - Abstract
Oxidative stress is a key element of the pathophysiology of heart failure (HF). As free thiols are readily oxidized by reactive oxygen and sulfur species, their circulating level may directly reflect the systemic redox status. This study addresses the role of serum free thiols in chronic HF, which is of particular interest as free thiols are amenable to therapeutic modulation and thus are a potential target for therapy.Free thiols were measured in serum of 101 previously characterized stable chronic HF patients (93% male, age 63.7 +/- 10.0 y, left ventricular ejection fraction 34.6 +/- 8.2%), adjusted for total serum protein, and subsequently analysed for associations with clinical and outcome parameters.The mean serum free thiol concentration was 3.6 +/- 0.5 mu M/g protein. Patients with above-average levels were younger, had better renal function, lower levels of NT-proBNP and PTH, and higher levels of cholesterol. Furthermore, above-average levels were associated with favourable disease outcome, i.e. a decreased rehospitalisation rate and increased patient survival (HR 0.27 (95% CI 0.11-0.62), P = 0.002) independent of associated clinical parameters, age and PTH. After adjustment for cholesterol or established prognostic factors in HF, eGFR and NT-proBNP the association was no longer significant, suggesting involvement of these variables in a common pathophysiological pathway.This exploratory study demonstrates favourable associations of serum free thiols with markers of HF severity and prognosis as well as disease outcome, which should be further investigated in larger prospective studies. Restoring redox status by therapeutic modulation of free thiols may be a promising strategy to improve disease outcome in CHF. (C) 2016 Elsevier Ltd. All rights reserved.
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- 2016
193. P1413 - Verfahren zur Metallisierung von Kunststoffteilen sowie Lösung
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Hofinger, J., Roos, S., Günther, T., and Maffert, A.
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Die Erfindung umfasst ein Verfahren zur Metallisierung von Kunststoffteilen mit den Schritten Vorbehandlung der Kunststoffoberfläche, chemische Metallisierung, wobei zur Vorbehandlung, die Oberfläche des Kunststoffteiles mit mindestens einer niedrig siedenden organischen Flüssigkeit angelöst und/oder angequollen wird, sodass anschließend die angelöste und/oder angequollene Kunststoffoberfläche durch Verdampfen der mindestens einen niedrig siedenden organischen Flüssigkeit strukturiert wird und sodass die so strukturierte Oberfläche ohne Chromsäure-Schwefelsäure-Lösung hydrophiliert wird.
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- 2016
194. Renal effects of long-term darbepoetin alpha treatment in hypertensive TGR(mRen2)27 rats
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Willem-Peter T. Ruifrok, Sippie Huitema, Harry van Goor, Rudolf A. de Boer, Marian Bulthuis, Anne-Roos S. Frenay, Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), and Groningen Kidney Center (GKC)
- Subjects
Male ,Medicine (General) ,Time Factors ,BLOCKADE ,Kidney Glomerulus ,renin-angiotensin system ,BLOOD-PRESSURE ,PROGRESSION ,Cell Count ,Kidney ,chemistry.chemical_compound ,ERYTHROPOIETIN PROTECTS ,Endocrinology ,Receptors, Erythropoietin ,Ren2 ,FAILURE ,Darbepoetin alfa ,Proteinuria ,biology ,darbepoetin alpha ,ISCHEMIA ,medicine.anatomical_structure ,Hypertension ,KIDNEY INJURY ,medicine.symptom ,medicine.medical_specialty ,Ischemia ,Alpha (ethology) ,R5-920 ,Internal medicine ,Renin–angiotensin system ,Internal Medicine ,medicine ,Animals ,cardiovascular diseases ,RNA, Messenger ,Erythropoietin ,ACEi ,Creatinine ,business.industry ,Macrophages ,HOMOZYGOUS TGR(MREN2)27 ,Angiotensin-converting enzyme ,medicine.disease ,Actins ,Rats ,MAP-KINASE ,Disease Models, Animal ,Collagen Type III ,Blood pressure ,CELL-DEATH ,Gene Expression Regulation ,chemistry ,biology.protein ,business ,Cell Adhesion Molecules - Abstract
Introduction: Erytropoietin (EPO) has cytoprotective and angiogenic properties and has a beneficial effect in ischaemic conditions. Since the development of renal interstitial abnormalities are often associated with ischaemia, we studied the effects of the long-acting EPO analogue darbepoetin alpha (DA) on kidney damage in TGR(mRen2)27 (Ren2) rats.Materials and methods: Ren2 rats were randomised to DA or vehicle (VEH) or to DA + angiotensin converting enzyme inhibitor (ACEi) or VEH + ACEi. Sprague Dawley (SD) rats served as controls. Blood pressure was measured weekly and 24-h urine was collected to measure proteinuria. Blood samples were collected for creatinine and haematocrit. Kidneys were studied for inflammation and pre-fibrosis. Renal mRNA expression was studied for EPO, EPO-receptor, collagen-3 alpha 1 and kidney injury molecule-1 (KIM-1).Results: DA had no effect on SBP, serum creatinine and proteinuria. Interstitial and glomerular alpha-SMA expression was significantly increased in Ren2. ACEi but not DA improved the increased renal inflammatory and pro-fibrotic profile in Ren2 rats. DA on top of ACEi further reduced glomerular alpha-SMA and KIM-1 expression.Conclusion: Long-term DA treatment has no beneficial effects on renal structural and functional changes in TGR(mRen2)27 rats in the time frame studied and the dose provided.
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- 2012
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195. 1 - Carbon footprints in the textile industry
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Peters, G., Svanström, M., Roos, S., Sandin, G., and Zamani, B.
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- 2015
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196. How useful is the Social Communication Questionnaire in toddlers at risk of autism spectrum disorder?
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Oosterling, I.J., Lambregts-Rommelse, N.N.J., Jonge, M. de, Gaag, R.J. van der, Swinkels, S.H.N., Roos, S., Visser, J., and Buitelaar, J.K.
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Mental Health [NCEBP 9] ,mental disorders ,Perception and Action [DCN 1] - Abstract
Contains fulltext : 88293.pdf (Publisher’s version ) (Closed access) BACKGROUND: The Social Communication Questionnaire (SCQ) is a screening instrument with established validity against the Autism Diagnostic Interview-Revised (ADI-R) in children aged 4 years and older. Indices of diagnostic accuracy have been shown to be strong in school-aged samples; however, relatively little is known about the performance of the SCQ in toddlers at risk of autism spectrum disorder (ASD). METHODS: This study replicates and extends previous research by Corsello et al. (2007) in a comparatively large (N = 208), substantially younger (20-40 months) sample of children at high risk of ASD. The usefulness of the SCQ as a second-level screening instrument with different cut-off scores was evaluated in relation to IQ, age, and type of ASD diagnosis. The use of the SCQ as compared to the ADI-R was evaluated against clinical diagnosis, both alone and in combination with the ADOS. RESULTS: The SCQ with different cut-offs consistently showed an unsatisfactory balance between sensitivity and specificity in screening for ASD in high-risk toddlers, with only a few exceptions for specific age, IQ, or diagnostic groups. Even though the SCQ and ADI-R were highly correlated, diagnostic agreement with the best evidence clinical diagnosis was poor for both measures. The ADOS used alone consistently had the highest predictive value. For autism versus not-autism, the combined SCQ and ADOS performed as well as the ADOS alone and notably better than the combination ADI-R and ADOS. CONCLUSIONS: The SCQ is likely to result in a number of false-positive findings, particularly in children with autism symptomatology, and the balance between sensitivity and specificity is poor. The ADOS should be considered the most valid and reliable diagnostic instrument in these very young at-risk children. 01 november 2010
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- 2010
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197. Blocking antibodies induced by allergen-specific immunotherapy ameliorate allergic airway disease in a human/mouse chimeric model
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Vizzardelli, C., primary, Gindl, M., additional, Roos, S., additional, Möbs, C., additional, Nagl, B., additional, Zimmann, F., additional, Sexl, V., additional, Kenner, L., additional, Neunkirchner, A., additional, Zlabinger, G. J., additional, Pickl, W. F., additional, Pfützner, W., additional, and Bohle, B., additional
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- 2017
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198. Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Minović, Isidor, primary, Eisenga, Michele F., additional, Riphagen, Ineke J., additional, van den Berg, Else, additional, Kootstra-Ros, Jenny, additional, Frenay, Anne-Roos S., additional, van Goor, Harry, additional, Rimbach, Gerald, additional, Esatbeyoglu, Tuba, additional, Levy, Andy P., additional, Gaillard, Carlo A. J. M., additional, Geleijnse, Johanna M., additional, Eggersdorfer, Manfred L., additional, Navis, Gerjan J., additional, Kema, Ido P., additional, and Bakker, Stephan J. L., additional
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- 2017
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199. 635 PUVA diminishes imiquimod-induced psoriatic phenotype with gene expression signature associated with senescence
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Shirsath, N., primary, Wagner, K., additional, Ober, J., additional, Mayer, G., additional, Schlederer, M., additional, Roos, S., additional, Kenner, L., additional, and Wolf, P., additional
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- 2017
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200. Acylcarnitine profile mimicking multiple acyl-CoA dehydrogenase deficiency in a patient with mitochondrial myopathy and a mutation in MT-CO2
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Roos, S., primary, Sofou, K., additional, Hedberg-Oldfors, C., additional, Kollberg, G., additional, Lindgren, U., additional, Thomsen, C., additional, Asin-Cayuela, J., additional, Tulinius, M., additional, and Oldfors, A., additional
- Published
- 2017
- Full Text
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