Search

Your search keyword '"Roberts, Lewis R."' showing total 1,784 results
Start Over Author "Roberts, Lewis R."
1,784 results on '"Roberts, Lewis R."'

153. High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence

Author

Mohamed, Essa A, primary, Giama, Nasra H, additional, Abdalla, Abubaker O, additional, Shaleh, Hassan M, additional, Oseini, Abdul M, additional, Ali, Hamdi A, additional, Ahmed, Fowsiyo, additional, Taha, Wesam, additional, Ahmed Mohammed, Hager, additional, Cvinar, Jessica, additional, Waaeys, Ibrahim A, additional, Ali, Hawa, additional, Allotey, Loretta K, additional, Ali, Abdiwahab O, additional, Mohamed, Safra A, additional, Harmsen, William S, additional, Ahmmad, Eimad M, additional, Bajwa, Numra A, additional, Afgarshe, Mohamud D, additional, Shire, Abdirashid M, additional, Balls-Berry, Joyce E, additional, and Roberts, Lewis R, additional

Published
2022
Full Text
View/download PDF

157. Disparities in curative treatments and outcomes for early stage intrahepatic cholangiocarcinoma in the United States

Author

Lee, Yi‐Te, primary, Singal, Amit G., additional, Lauzon, Marie, additional, Agopian, Vatche G., additional, Luu, Michael, additional, Noureddin, Mazen, additional, Todo, Tsuyoshi, additional, Kim, Irene K., additional, Friedman, Marc L., additional, Kosari, Kambiz, additional, Nissen, Nicholas N., additional, Roberts, Lewis R., additional, Heimbach, Julie K., additional, Gores, Gregory J., additional, and Yang, Ju Dong, additional

Published
2022
Full Text
View/download PDF

163. Hepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy

Author

Debes, Jose D., Chan, Aaron J., Balderramo, Domingo, Kikuchi, Luciana, Gonzalez Ballerga, Esteban, Prieto, Jhon E., Tapias, Monica, Idrovo, Victor, Davalos, Milagros B., Cairo, Fernando, Barreyro, Fernando J., Paredes, Sebastian, Hernandez, Nelia, Avendaño, Karla, Diaz Ferrer, Javier, Yang, Ju Dong, Carrera, Enrique, Garcia, Jairo A., Mattos, Angelo Z., Hirsch, Bruno S., Gonçalves, Pablo T., Carrilho, Flair J., and Roberts, Lewis R.

Published
2018
Full Text
View/download PDF

164. Prevalence of hepatitis B antiviral drug resistance variants in North American patients with chronic hepatitis B not receiving antiviral treatment

Author

Lok, A. S., Ganova‐Raeva, L., Cloonan, Y., Punkova, L., Lin, H.‐H. S., Lee, W. M., Ghany, M. G., Lau, Daryl T‐Y, Chung, Raymond T., Roberts, Lewis R., Smith, Coleman I., Di Bisceglie, Adrian M., ‐Melman, Mauricio, Janssen, L. A., Wong, David K., Juan, Joshua, Feld, Jordan, Yim, Colina, Heathcote, Jenny, Perrillo, Robert, Do, Son, Han, Steven‐Huy B., Tran, Tram T., Terrault, Norah A., Khalili, Mandana, Cooper, Stewart L., Fontana, Robert J., Tsai, Naoky, Fried, Michael W., Patel, Keyur, Evon, Donna, Carithers, Robert C., Shuhart, Margaret, Kowdley, Kris V., Wang, Chia C., Sterling, Richard K., Jake Liang, T., Hoofnagle, Jay H., Doo, Edward, Chang, Kyong‐Mi, Park, Jang‐June, Belle, Steven H., Wahed, Abdus, and Kleiner, David

Published
2017
Full Text
View/download PDF

165. Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B.

Author

Terrault, Norah A., Lok, Anna S., Wahed, Abdus S., Ghany, Marc G., Perrillo, Robert P., Fried, Michael W., Wong, David K., Khalili, Mandana, Lau, Daryl T. Y., Sterling, Richard K., Di Bisceglie, Adrian M., Lisker-Melman, Mauricio, Cooper, Stewart L., Chung, Ray T., Patel, Keyur, Roberts, Lewis R., Belle, Steven H., and Janssen, Harry L. A.

Published
2023
Full Text
View/download PDF

166. Immunostaining for hepatitis B viral antigens in liver: Association with clinical, biochemical, and virologic features of disease.

Author

Kleiner, David E, Lisker‐Melman, Mauricio, Wahed, Abdus S, Bhan, Atul K, Nalesnik, Michael A, Choi, Eun‐Young K, Leonard, Kelsey K, Ghany, Marc G, Chung, Raymond T, Di Bisceglie, Adrian M, Lau, Daryl T‐Y, Roberts, Lewis R, Hassan, Mohamed A, Schwarzenberg, Sarah Jane, Teckman, Jeffrey, Janssen, Harry L A, Wong, David K, Juan, Joshua, Feld, Jordan, and Yim, Colina

Subjects
HEPATITIS associated antigen, CHRONIC hepatitis B, VIRAL hepatitis, HEPATITIS B, IMMUNOSTAINING, HEPATITIS E
Abstract

Background and Aim: Staining for hepatitis B viral antigens is often done in liver biopsies from patients with chronic hepatitis B, but its correlates with clinical phenotypes are not well described. Methods: Biopsies were collected from a large cohort of adults and children with chronic hepatitis B viral infection through the Hepatitis B Research Network. Immunohistochemical staining of sections was done for hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) and then centrally read by the pathology committee. The degree of liver injury and pattern of staining were then correlated with clinical characteristics, including the clinical phenotype of hepatitis B. Results: Biopsies from 467 subjects were studied, including 46 from children. Immunostaining for HBsAg was positive in 417 (90%) with scattered hepatocyte staining being the most common pattern. HBsAg staining correlated best with serum levels of HBsAg and hepatitis B viral DNA; the absence of HBsAg staining was often a prelude to loss of HBsAg from serum. HBcAg staining was positive in 225 (49%), and, while cytoplasmic staining was more frequent than nuclear staining, both nuclear and cytoplasmic positivity were often seen in the same specimen. Staining for HBcAg correlated with both level of viremia and liver injury. No biopsies from inactive carriers had stainable HBcAg, while 91% of the biopsies from those with hepatitis B e antigen‐positive chronic hepatitis B stained positively for HBcAg. Conclusion: Immunostaining for hepatitis B viral antigens may yield helpful insights into liver disease pathogenesis but appears to add little to commonly used serological and biochemical blood tests. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

169. Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

Author

Lee, Sung Hwan, primary, Yim, Sun Young, additional, Jeong, Yun Seong, additional, Li, Qi‐Xiang, additional, Kang, Sang‐Hee, additional, Sohn, Bo Hwa, additional, Kumar, Shwetha V., additional, Shin, Ji‐Hyun, additional, Choi, You Rhee, additional, Shim, Jae‐Jun, additional, Kim, Hayeon, additional, Kim, Ji Hoon, additional, Kim, Shin, additional, Guo, Sheng, additional, Johnson, Randy L., additional, Kaseb, Ahmed, additional, Kang, Koo Jeong, additional, Chun, Yun Shin, additional, Jang, Hee Jin, additional, Lee, Byoung Gill, additional, Woo, Hyun Goo, additional, Ha, Min Jin, additional, Akbani, Rehan, additional, Roberts, Lewis R., additional, Wheeler, David A., additional, and Lee, Ju‐Seog, additional

Published
2022
Full Text
View/download PDF

171. DEVELOPMENT AND VALIDATION OF A CYTOLOGY-BASED DEEP LEARNING ARTIFICIAL INTELLIGENCE MODEL FOR DIAGNOSING BILIARY TRACT MALIGNANCIES

Author

Marya, Neil B., primary, Hartley, Christopher, additional, Powers, Patrick D., additional, Bois, Melanie, additional, Kerr, Sarah, additional, Gleeson, Ferga C., additional, Abu Dayyeh, Barham K., additional, Kipp, Benjamin R., additional, Law, Ryan, additional, Martin, John A., additional, Petersen, Bret T., additional, Storm, Andrew C., additional, Vargas, Eric J., additional, Roberts, Lewis R., additional, Gores, Gregory J., additional, Graham, Rondell, additional, and Levy, Michael J., additional

Published
2022
Full Text
View/download PDF

175. 949: PROGNOSTIC LIVER SECRETOME SIGNATURE AND ALPHA-FETOPROTEIN (PLSEC-AFP) PREDICTS LONG-TERM HEPATOCELLULAR CARCINOMA RISK IN PATIENTS WITH CIRRHOSIS: A NATIONWIDE PHASE 3 BIOMARKER STUDY IN THE U.S.

Author

Fujiwara, Naoto, primary, Marsh, Tracey L., additional, Marquez, Cesia A., additional, Raman, Indu, additional, Li, Quan-Zhen, additional, Parikh, Neehar D., additional, Roberts, Lewis R., additional, Schwartz, Myron, additional, Nguyen, Mindie H., additional, Befeler, Alex, additional, Page-Lester, Stephanie, additional, Srivastava, Sudhir, additional, Rinaudo, Jo Ann, additional, Feng, Ziding, additional, Marrero, Jorge A., additional, Reddy, K. Rajender, additional, Singal, Amit G., additional, and Hoshida, Yujin, additional

Published
2022
Full Text
View/download PDF

176. Impact of trimodality sampling on detection of malignant biliary strictures compared with patients with primary sclerosing cholangitis

Author

Baroud, Serge, primary, Sahakian, Alexander J., additional, Sawas, Tarek, additional, Storm, Andrew C., additional, Martin, John A., additional, Abu Dayyeh, Barham K., additional, Topazian, Mark D., additional, Levy, Michael J., additional, Roberts, Lewis R., additional, Gores, Gregory J., additional, Petersen, Bret T., additional, and Chandrasekhara, Vinay, additional

Published
2022
Full Text
View/download PDF

177. 528: THE MULTI-TARGET HEPATOCELLULAR CARCINOMA BLOOD TEST PROVIDES HIGH SENSITIVITY FOR DETECTING EARLY-STAGE HEPATOCELLULAR CARCINOMA ACROSS IMPORTANT PATIENT SUBGROUPS

Author

Chalasani, Naga P., primary, Porter, Kyle, additional, Book, Adam J., additional, Xiong, Kong M., additional, Ramasubramanian, Tiruvidaimarudur S., additional, Kielar-Grevstad, Elle, additional, Roberts, Lewis R., additional, Kisiel, John B., additional, Reddy, Rajender, additional, Singal, Amit G., additional, Olson, Marilyn, additional, and Bruinsma, Janelle, additional

Published
2022
Full Text
View/download PDF

178. 950: REAL-WORLD EFFECTIVENESS AND RACIAL/ETHNIC DISPARITIES IN IMMUNOTHERAPY FOR ADVANCED HEPATOCELLULAR CARCINOMA: ANALYSIS OF US NATIONAL CANCER DATABASE

Author

Ahn, Joseph C., primary, Lauzon, Marie, additional, Luu, Michael, additional, Noureddin, Mazen, additional, Ayoub, Walid S., additional, Kuo, Alexander, additional, Sundaram, Vinay, additional, Kosari, Kambiz, additional, Nissen, Nicholas N., additional, Gong, Jun, additional, Hendifar, Andrew, additional, Roberts, Lewis R., additional, Abou-Alfa, Ghassan K., additional, Singal, Amit G., additional, and Yang, Ju Dong, additional

Published
2022
Full Text
View/download PDF

185. 1052 PAAM FOR HEPATOCELLULAR CARCINOMA RISK STRATIFICATION IN PATIENTS WITH CIRRHOSIS: MULTICENTER PHASE 3 BIOMARKER VALIDATION STUDIES IN THE U.S.

Author

Fujiwara, Naoto, Lopez, Camden, Marsh, Tracey L., Raman, Indu, Marquez, Cesia A., Paul, Subhojit, Mishra, Sumit K., Kubota, Naoto, Katz, Courtney, Kanzaki, Hiroaki, Gonzales, Michael, Quirk, Lisa, Deodhar, Sneha, Selvakumar, Pratibha, Raj, Prithvi, Parikh, Neehar D., Roberts, Lewis R., Schwartz, Myron, Nguyen, Mindie H., Befeler, Alex, Page-Lester, Stephanie, Rinaudo, Jo Ann, Feng, Ziding, Reddy, Rajender, Khaderi, Saira, Asrani, Sumeet K., Kanwal, Fasiha, El-Serag, Hashem B., Marrero, Jorge A., Singal, Amit G., and Hoshida, Yujin

Published
2024
Full Text
View/download PDF

186. Mo1473 PREVALENCE OF RARE GERMLINE VARIANTS IN HEPATOCELLULAR CARCINOMA IN A GLOBAL MULTI-ETHNIC CASE-CONTROL GENETIC ASSOCIATION STUDY

Author

Chotiprasidhi, Perapa, Espinoza, Karina Sato, Ma, Jun, Nartey, Yvonne A., Duah, Amoako, Agyei-Nkansah, Adwoa, Awuku, Yaw A., Afihene, Mary, Asibey, Shadrack O., Ayawin, Joshua, Bampoh, Sally A., Plymoth, Amelie, Ferrer, Javier Diaz, Prieto, Jhon, Balderramo, Domingo, Arrese, Marco, Mattos, Ângelo Z., Carrera, Enrique, Wang, Jun, Zheng, Yinan, Hou, Lifang, Hawkins, Claudia, Murphy, Robert, Imade, Godwin, Okeke, Edith N., Akanmu, Alani, Lesi, Olufunmilayo, Roberts, Lewis R., Debes, Jose D., Antwi, Samuel O., and Wangensteen, Kirk J.

Published
2024
Full Text
View/download PDF

188. Elevated rates of horizontal gene transfer in the industrialized human microbiome

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences, Groussin, Mathieu, Poyet, Mathilde, Sistiaga Guiterrez, Maria Ainara, Kearney, Sean Michael, Moniz, Katya H, Noel, Mary, Hooker, Jeff, Gibbons, Sean Michael, Segurel, Laure, Froment, Alain, Mohamed, Rihlat Said, Fezeu, Alain, Juimo, Vanessa A., Lafosse, Sophie, Tabe, Francis E., Girard, Catherine, Iqaluk, Deborah, Nguyen, Le Thanh Tu, Shapiro, B. Jesse, Lehtimäki, Jenni, Ruokolainen, Lasse, Kettunen, Pinja P., Vatanen, Tommi, Sigwazi, Shani, Mabulla, Audax, Domínguez-Rodrigo, Manuel, Nartey, Yvonne A., Agyei-Nkansah, Adwoa, Duah, Amoako, Awuku, Yaw A., Valles, Kenneth A., Asibey, Shadrack O., Afihene, Mary Y., Roberts, Lewis R., Plymoth, Amelie, Onyekwere, Charles A., Summons, Roger E, Xavier, Ramnik Joseph, Alm, Eric J, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences, Groussin, Mathieu, Poyet, Mathilde, Sistiaga Guiterrez, Maria Ainara, Kearney, Sean Michael, Moniz, Katya H, Noel, Mary, Hooker, Jeff, Gibbons, Sean Michael, Segurel, Laure, Froment, Alain, Mohamed, Rihlat Said, Fezeu, Alain, Juimo, Vanessa A., Lafosse, Sophie, Tabe, Francis E., Girard, Catherine, Iqaluk, Deborah, Nguyen, Le Thanh Tu, Shapiro, B. Jesse, Lehtimäki, Jenni, Ruokolainen, Lasse, Kettunen, Pinja P., Vatanen, Tommi, Sigwazi, Shani, Mabulla, Audax, Domínguez-Rodrigo, Manuel, Nartey, Yvonne A., Agyei-Nkansah, Adwoa, Duah, Amoako, Awuku, Yaw A., Valles, Kenneth A., Asibey, Shadrack O., Afihene, Mary Y., Roberts, Lewis R., Plymoth, Amelie, Onyekwere, Charles A., Summons, Roger E, Xavier, Ramnik Joseph, and Alm, Eric J

Abstract

Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.

Published
2022

189. Early Age Hepatocellular Carcinoma Associated With Hepatitis B Infection in South America

Author

Chan, Aaron J., Balderramo, Domingo, Kikuchi, Luciana, Ballerga, Esteban Gonzalez, Prieto, Jhon E., Tapias, Monica, Idrovo, Victor, Davalos, Milagros B., Cairo, Fernando, Barreyro, Fernando J., Paredes, Sebastian, Hernandez, Nelia, Avendaño, Karla, Ferrer, Javier Diaz, Yang, Ju Dong, Carrera, Enrique, Mattos, Angelo Z., Hirsch, Bruno S., Gonçalves, Pablo T., Carrilho, Flair J., Roberts, Lewis R., and Debes, Jose D.

Published
2017
Full Text
View/download PDF

193. TACE versus TARE for patients with hepatocellular carcinoma: Overall and individual patient level meta analysis.

Author

Brown, Andrew M., Kassab, Ihab, Massani, Marco, Townsend, Whitney, Singal, Amit G., Soydal, Cigdem, Moreno‐Luna, Laura, Roberts, Lewis R., Chen, Vincent L., and Parikh, Neehar D.

Subjects
HEPATOCELLULAR carcinoma, CHEMOEMBOLIZATION, LIVER cancer, TUMOR classification, OVERALL survival
Abstract

Background: Transarterial radioembolization (TARE) is increasingly used as an alternative to transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). We aimed to perform an overall and individual patient data (IPD) meta‐analysis of studies comparing TACE and TARE. Methods: We performed a systematic literature search using pre‐specified keywords with the aid of an informationist for articles from inception to 3/2020. The primary endpoint was overall survival (OS), and the secondary endpoint was time to progression (TTP). Results: Seventeen studies met inclusion criteria with 2465 unique patients, with one randomized trial, 4 prospective studies and 12 retrospective studies. Barcelona Clinic Liver Cancer (BCLC) stage B (42.8%) was the most common stage followed by BCLC A (30.3%) and BCLC C (29.0%). There was no difference in OS between the two modalities (−0.55 months, 95% CI −1.95 to 3.05). In three studies with available TTP data, TARE resulted in a longer TTP than TACE (mean TTP 17.5 vs. 9.8 months; mean TTP difference 4.8 months, 95% CI 1.3–8.3 months). IPD‐level meta‐analysis of 311 patients from three studies showed no difference in overall OS between the two modalities including among subgroups stratified by tumor stage and liver function. Limitations of the current literature include inconsistent length of follow‐up, inconsistency in response criteria, and safety reporting. Conclusions: Current data suggest TARE provides significantly longer TTP than TACE, although the two treatments do not significantly differ in terms of OS. Given limitations of the current data, there is rationale for prospective studies comparing these modalities. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

199. Racial and ethnic disparities in early treatment with immunotherapy for advanced HCC in the United States

Author

Ahn, Joseph C., primary, Lauzon, Marie, additional, Luu, Michael, additional, Noureddin, Mazen, additional, Ayoub, Walid, additional, Kuo, Alexander, additional, Sundaram, Vinay, additional, Kosari, Kambiz, additional, Nissen, Nicholas, additional, Gong, Jun, additional, Hendifar, Andrew, additional, Roberts, Lewis R., additional, Abou‐Alfa, Ghassan K., additional, Singal, Amit G., additional, and Yang, Ju Dong, additional

Published
2022
Full Text
View/download PDF

200. 310 Transcriptomics for gallbladder cancer prognosis

Author

Jackson, Linsey, primary, Allotey, Loretta K., additional, Valles, Kenneth, additional, Oliver, Gavin R., additional, Nair, Asha, additional, Obrien, Daniel R., additional, Graham, Rondell P., additional, Borad, Mitesh J, additional, Athreya, Arjun, additional, and Roberts, Lewis R., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results