1,469 results on '"Röösli, Martin"'
Search Results
152. Comparing Methods to Impute Missing Daily Ground-Level PM10 Concentrations between 2010–2017 in South Africa
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Arowosegbe, Oluwaseyi Olalekan, Röösli, Martin, Künzli, Nino, Saucy, Apolline, Adebayo-Ojo, Temitope Christina, Jeebhay, Mohamed F., Dalvie, Mohammed Aqiel, and de Hoogh, Kees
- Abstract
Good quality and completeness of ambient air quality monitoring data is central in supporting actions towards mitigating the impact of ambient air pollution. In South Africa, however, availability of continuous ground-level air pollution monitoring data is scarce and incomplete. To address this issue, we developed and compared different modeling approaches to impute missing daily average particulate matter (PM10) data between 2010 and 2017 using spatiotemporal predictor variables. The random forest (RF) machine learning method was used to explore the relationship between average daily PM10 concentrations and spatiotemporal predictors like meteorological, land use and source-related variables. National (8 models), provincial (32) and site-specific (44) RF models were developed to impute missing daily PM10 data. The annual national, provincial and site-specific RF cross-validation (CV) models explained on average 78%, 70% and 55% of ground-level PM10 concentrations, respectively. The spatial components of the national and provincial CV RF models explained on average 22% and 48%, while the temporal components of the national, provincial and site-specific CV RF models explained on average 78%, 68% and 57% of ground-level PM10 concentrations, respectively. This study demonstrates a feasible approach based on RF to impute missing measurement data in areas where data collection is sparse and incomplete.
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- 2021
153. Health effects of WiFi radiation: a review based on systematic quality evaluation.
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Dongus, Stefan, Jalilian, Hamed, Schürmann, David, and Röösli, Martin
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ELECTROMAGNETIC fields ,BIOMARKERS ,RADIATION ,RADIO frequency ,IN vitro studies - Abstract
Although WiFi contributes little to total radiofrequency electromagnetic field (RF-EMF) exposure in our everyday environment, concern has raised whether this specific type of modulated RF-EMF causes health problems. The aim of this review is to evaluate all types of studies that investigated biological and health effects of WiFi exposure and fulfilled basic quality criteria. Eligible for inclusion were epidemiological, human experimental, in vivo and in vitro studies using realistic WiFi exposure settings. We conducted a systematic literature search for all papers published between January 1997 and August 2020 followed by a quality review addressing blinding and dosimetry in experimental studies and various types of biases in epidemiological studies. All studies fulfilling the quality criteria were descriptively summarized in terms of observation or absence of associations. From 1385 articles identified by the literature search, 23 fulfilled basic quality criteria: 6 epidemiological papers, 6 human experimental articles, 9 in vivo articles, and 2 in vitro articles. Whereas in vivo and in vitro studies applied exposure levels up to 4 W/kg, human studies dealt with exposure levels several orders of magnitude below the ICNIRP guidelines, which are typical for WiFi exposure situations in the everyday environment. Numerous outcomes ranging from biological markers to symptoms were mostly found not to be associated with WiFi exposure. Sporadic findings were not consistent in terms of outcomes or exposure-response associations. This review based on a systematic literature search and quality evaluation does not suggest detrimental health effects from WiFi exposure below regulatory limits. [ABSTRACT FROM AUTHOR]
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- 2022
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154. Impact of one’s own mobile phone in stand-by mode on personal radiofrequency electromagnetic field exposure
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Urbinello, Damiano and Röösli, Martin
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- 2013
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155. 5 Umwelt
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Egger, Matthias, primary, Kuehni, Claudia, additional, Künzli, Nino, additional, Hoffmann, Barbara, additional, Röösli, Martin, additional, Babisch, Wolfgang, additional, Berg-Beckhoff, Gabriele, additional, and Blettner, Maria, additional
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- 2014
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156. Health effects of WiFi radiation: a review based on systematic quality evaluation
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Dongus, Stefan, primary, Jalilian, Hamed, additional, Schürmann, David, additional, and Röösli, Martin, additional
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- 2021
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157. Estimation of Heat-Attributable Mortality Using the Cross-Validated Best Temperature Metric in Switzerland and South Korea
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Lee, Jae Young, primary, Röösli, Martin, additional, and Ragettli, Martina S., additional
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- 2021
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158. Diarrhoea among Children Aged under Five Years and Risk Factors in Informal Settlements: A Cross-Sectional Study in Cape Town, South Africa
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Nguyen, Thi Yen Chi, primary, Fagbayigbo, Bamidele Oladapo, additional, Cissé, Guéladio, additional, Redi, Nesre, additional, Fuhrimann, Samuel, additional, Okedi, John, additional, Schindler, Christian, additional, Röösli, Martin, additional, Armitage, Neil Philip, additional, Carden, Kirsty, additional, and Dalvie, Mohamed Aqiel, additional
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- 2021
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159. Use of Mobile Phones and Brain Cancer Risk in Children?
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Röösli, Martin, primary, Feychting, Maria, additional, and Schüz, Joachim, additional
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- 2013
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160. Radiofrequency electromagnetic fields from mobile communication: Description of modeled dose in brain regions and the body in European children and adolescents
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Birks, Laura Ellen, van Wel, Luuk, Liorni, Ilaria, Pierotti, Livia, Guxens, Mònica, Huss, Anke, Foerster, Milena, Capstick, Myles, Eeftens, Marloes, El Marroun, Hanan, Estarlich, Marisa, Gallastegi, Mara, Safont, Llúcia González, Joseph, Wout, Santa-Marina, Loreto, Thielens, Arno, Torrent, Maties, Vrijkotte, Tanja, Wiart, Joe, Röösli, Martin, Cardis, Elisabeth, Vermeulen, Roel, Vrijheid, Martine, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Institut Polytechnique de Paris (IP Paris), Chaire Modélisation, Caractérisation et Maîtrise des expositions aux ondes électromagnétiques (C2M), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Télécom ParisTech, Département Communications & Electronique (COMELEC), Télécom ParisTech, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Amsterdam Reproduction & Development (AR&D), APH - Aging & Later Life, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Child and Adolescent Psychiatry / Psychology, Clinical Psychology, and Pediatrics
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medicine.medical_specialty ,Technology and Engineering ,Adolescent ,Rf exposure ,010501 environmental sciences ,Audiology ,01 natural sciences ,Biochemistry ,Temporal lobe ,03 medical and health sciences ,0302 clinical medicine ,Environmental Science(all) ,Medicine and Health Sciences ,Medicine ,Humans ,030212 general & internal medicine ,Child ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,General Environmental Science ,Netherlands ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,Potential risk ,business.industry ,Communication ,Children’s health ,Parietal lobe ,Radio waves ,Brain ,Electromagnetic fields ,Environmental Exposure ,Children's health ,Frontal lobe ,Spain ,Earth and Environmental Sciences ,Large study ,Mobile telephony ,Occipital lobe ,business ,Cell phone use ,Cell Phone ,Switzerland - Abstract
BACKGROUND: Little is known about radiofrequency electromagnetic fields (RF) from mobile technology and resulting dose in young people. We describe modeled integrated RF dose in European children and adolescents combining own mobile device use and surrounding sources. METHODS: Using an integrated RF model, we estimated the daily RF dose in the brain (whole-brain, cerebellum, frontal lobe, midbrain, occipital lobe, parietal lobe, temporal lobes) and the whole-body in 8358 children (ages 8-12) and adolescents (ages 14-18) from the Netherlands, Spain, and Switzerland during 2012-2016. The integrated model estimated RF dose from near-field sources (digital enhanced communication technology (DECT) phone, mobile phone, tablet, and laptop) and far-field sources (mobile phone base stations via 3D-radiowave modeling or RF measurements). RESULTS: Adolescents were more frequent mobile phone users and experienced higher modeled RF doses in the whole-brain (median 330.4 mJ/kg/day) compared to children (median 81.8 mJ/kg/day). Children spent more time using tablets or laptops compared to adolescents, resulting in higher RF doses in the whole-body (median whole-body dose of 81.8 mJ/kg/day) compared to adolescents (41.9 mJ/kg/day). Among brain regions, temporal lobes received the highest RF dose (medians of 274.9 and 1786.5 mJ/kg/day in children and adolescents, respectively) followed by the frontal lobe. In most children and adolescents, calling on 2G networks was the main contributor to RF dose in the whole-brain (medians of 31.1 and 273.7 mJ/kg/day, respectively). CONCLUSION: This first large study of RF dose to the brain and body of children and adolescents shows that mobile phone calls on 2G networks are the main determinants of brain dose, especially in temporal and frontal lobes, whereas whole-body doses were mostly determined by tablet and laptop use. The modeling of RF doses provides valuable input to epidemiological research and to potential risk management regarding RF exposure in young people.
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- 2021
161. Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents
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Cabré-Riera, Alba, van Wel, Luuk, Liorni, Ilaria, Thielens, Arno, Birks, Laura Ellen, Pierotti, Livia, Joseph, Wout, González-Safont, Llúcia, Ibarluzea, Jesús, Ferrero, Amparo, Huss, Anke, Wiart, Joe, Santa-Marina, Loreto, Torrent, Maties, Vrijkotte, Tanja, Capstick, Myles, Vermeulen, Roel, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Guxens, Mònica, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, ARD - Amsterdam Reproduction and Development, APH - Aging & Later Life, Child and Adolescent Psychiatry / Psychology, Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Institut Polytechnique de Paris (IP Paris), Chaire Modélisation, Caractérisation et Maîtrise des expositions aux ondes électromagnétiques (C2M), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Télécom ParisTech, Département Communications & Electronique (COMELEC), Télécom ParisTech, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
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Wireless technology ,CHILDREN ,010501 environmental sciences ,WIRELESS COMMUNICATION ,01 natural sciences ,0302 clinical medicine ,Cognition ,Interquartile range ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,Child ,Prospective cohort study ,ComputingMilieux_MISCELLANEOUS ,MOBILE PHONE USE ,education.field_of_study ,Cognitive flexibility ,Radio waves ,Brain ,Public Health ,Cell phone use ,Technology and Engineering ,animal structures ,Adolescent ,Population ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Humans ,EXPOSURE ,VALIDITY ,Association (psychology) ,education ,0105 earth and related environmental sciences ,Working memory ,business.industry ,Environmental and Occupational Health ,MEMORY ,Public Health, Environmental and Occupational Health ,Semantic fluency ,Electromagnetic fields ,Environmental Exposure ,PERFORMANCE ,[SDE.ES]Environmental Sciences/Environmental and Society ,Cross-Sectional Studies ,PROSPECTIVE COHORT ,RADIATION ,MORPHOLOGY ,business ,Cell Phone ,Demography - Abstract
Objective: To investigate the association between estimated whole-brain radiofrequency electromagnetic fields (RF-EMF) dose, using an improved integrated RF-EMF exposure model, and cognitive function in preadolescents and adolescents. Methods: Cross-sectional analysis in preadolescents aged 9-11 years and adolescents aged 17-18 years from the Dutch Amsterdam Born Children and their Development Study (n = 1664 preadolescents) and the Spanish INfancia y Medio Ambiente Project (n = 1288 preadolescents and n = 261 adolescents), two population-based birth cohort studies. Overall whole-brain RF-EMF doses (mJ/kg/day) were estimated for several RF-EMF sources together including mobile and Digital Enhanced Cordless Telecommunications phone calls (named phone calls), other mobile phone uses than calling, tablet use, laptop use (named screen activities), and far-field sources. We also estimated whole-brain RF-EMF doses in these three groups separately (i.e. phone calls, screen activities, and far-field) that lead to different patterns of RF-EMF exposure. We assessed non-verbal intelligence in the Dutch and Spanish preadolescents, information processing speed, attentional function, and cognitive flexibility in the Spanish preadolescents, and working memory and semantic fluency in the Spanish preadolescents and adolescents using validated neurocognitive tests. Results: Estimated overall whole-brain RF-EMF dose was 90.1 mJ/kg/day (interquartile range (IQR) 42.7; 164.0) in the Dutch and Spanish preadolescents and 105.1 mJ/kg/day (IQR 51.0; 295.7) in the Spanish adolescents. Higher overall estimated whole-brain RF-EMF doses from all RF-EMF sources together and from phone calls were associated with lower non-verbal intelligence score in the Dutch and Spanish preadolescents (-0.10 points, 95% CI-0.19; -0.02 per 100 mJ/kg/day increase in each exposure). However, none of the whole-brain RF-EMF doses was related to any other cognitive function outcome in the Spanish preadolescents or adolescents. Conclusions: Our results suggest that higher brain exposure to RF-EMF is related to lower non-verbal intelligence but not to other cognitive function outcomes. Given the cross-sectional nature of the study, the small effect sizes, and the unknown biological mechanisms, we cannot discard that our resultsare due to chance finding or reverse causality. Longitudinal studies on RF-EMF brain exposure and cognitive function are needed.
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- 2021
162. Quantitative assessment of multiple pesticides in silicone wristbands of children/guardian pairs living in agricultural areas in South Africa
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Fuhrimann, Samuel, Mol, Hans G J, Dias, Jonatan, Dalvie, Mohamed Aqiel, Röösli, Martin, Degrendele, Céline, Figueiredo, Daniel M, Huss, Anke, Portengen, Lutzen, Vermeulen, Roel, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, Institute for Risk Assessment Sciences [Utrecht, The Netherlands] (IRAS), Utrecht University [Utrecht], Wageningen Food Safety Research, Wageningen (WFSR), University of Cape Town, Swiss Tropical and Public Health Institute [Basel], Laboratoire Chimie de l'environnement (LCE), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), dIRAS RA-2, and IRAS OH Epidemiology Chemical Agents
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Environmental Engineering ,Silicones ,Boscalid ,Exposure ,Organophosphates ,Organochlorines ,Pesticide ,Pyrethroids ,Household ,Wristbands ,Environmental Exposure ,[SDE.ES]Environmental Sciences/Environmental and Society ,Pollution ,Team Pesticides 2 ,South Africa ,Tandem Mass Spectrometry ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,Humans ,Environmental Chemistry ,Pesticides ,Child ,Waste Management and Disposal - Abstract
Little is known about personal and time-integrated exposure to past and current used pesticides in agricultural areas and within-family exposure similarities. We aimed to assess exposure to pesticides using silicone wristbands in child/guardian pairs living on farms and in villages within two agricultural areas in South Africa. Using silicone wristbands, we quantified 21 pesticides in child/guardian pairs in 38 households over six days in 2018. Levels (in ng/g wristband) of pesticides and their transformation products (12 current-use pesticides and nine organochlorine pesticides) were measured using GC-MS/MS. We assessed the correlation between pesticide levels and between household members using Spearman correlation coefficients (r(s)). Multivariable generalized least squares (GLS) models, using household id as intercept, were used to determine level of agreement between household members, exposure differences between children and guardians and exposure predictors (study area, household location [farm vs. village] and household pesticide use). We detected 16 pesticides with highest detection frequencies for deltamethrin (89%), chlorpyrifos (78%), boscalid (56%), cypermethrin (55%), and p,p'-DDT (48%). Most wristbands (92%) contained two or more pesticides (median seven (range one to 12)). Children had higher concentrations than guardians for four pesticides. Correlation between the pesticide levels were in most cases moderate (rs 0.30-0.68) and stronger in children than in guardians. Five pesticides showed moderate to strong correlation between household members, with the strongest correlation for boscalid (r(s) 0.84). Exposure differences between the two agricultural areas were observed for chlorpyri fas, diazinon, pmthiofos, cypermethrin, boscalid, p,p'-DDT and p,p'-DDE and within areas for cypermethrin. We showed that for several pesticides children had higher exposure levels than guardians. The positive correlations observed for child/guardian pairs living in the same household suggest non-occupational shared exposure pathways in these communities.
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- 2021
163. Onkologie
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Schüz, Joachim, Rohrmann, Sabine, Röösli, Martin, University of Zurich, Traidl-Hoffmann, Claudia, Schulz, Christian, Herrmann, Martin, and Simon, Babette
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610 Medicine & health ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) - Published
- 2021
164. Digital technology use and BMI: evidence from a cross-sectional analysis of an adolescent cohort study
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Shen, Chen, Dumontheil, Iroise, Thomas, Michael, Röösli, Martin, Elliott, Paul, Toledano, Mireille, Medical Research Council (MRC), Imperial College Healthcare NHS Trust- BRC Funding, National Institute for Health Research, and Department of Health
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Male ,Original Paper ,obesity ,mobile phone ,Digital Technology ,Adolescent ,17 Psychology and Cognitive Sciences ,Body Mass Index ,Cohort Studies ,insufficient sleep ,Cross-Sectional Studies ,Humans ,Sleep Deprivation ,Female ,08 Information and Computing Sciences ,mediation analysis ,Medical Informatics ,11 Medical and Health Sciences - Abstract
Background: The use of digital technology such as mobile phones is ubiquitous in adolescents. However, excessive use may have adverse health effects, possibly partially mediated by disruptions to sleep. Objective: This study aims to assess the social predictors of digital technology use and their cross-sectional association with BMI z scores and being overweight in a large sample of adolescents. Methods: We used baseline data from a subset of a large adolescent cohort from 39 schools across Greater London who participated in the Study of Cognition, Adolescents and Mobile Phones (n=1473). Digital technology use included phone calls, internet use on mobile phones, and video gaming on any device. Multilevel regression was used to assess the associations between digital technology use and age-specific and sex-specific BMI z scores and being overweight (including obesity). Measurements were derived from height and weight, obtained by the Tanita BC-418 Body Composition Analyzer. We examined whether these associations were mediated by insufficient sleep. Results: Generally, participants with lower socioeconomic status reported more use of digital technology. Controlling for socioeconomic status, internet use on mobile phones for more than 3 hours per day was associated with higher BMI z scores (adjusted β=.30, 95% CI 0.11-0.48) and greater odds of being overweight (adjusted odds ratio 1.60, 95% CI 1.09-2.34), compared with low use (≤30 minutes). Similar associations were found between video gaming and BMI z scores and being overweight. The BMI z score was more strongly related to weekday digital technology use (internet use on mobile phones and video gaming) than weekend use. Insufficient sleep partly mediated the associations between digital technology use and BMI z scores (proportion of mediation from 8.6% to 17.8%) by an indirect effect. Conclusions: We found an association between digital technology use and BMI in adolescents, partly mediated by insufficient sleep, suggesting that the underlying mechanisms may be multifactorial. Further research with longitudinal data is essential to explore the direction of the relationships.
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- 2021
165. Radiofrequency electromagnetic fields from mobile communication: Description of modeled dose in brain regions and the body in European children and adolescents
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One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Birks, Laura Ellen, van Wel, Luuk, Liorni, Ilaria, Pierotti, Livia, Guxens, Mònica, Huss, Anke, Foerster, Milena, Capstick, Myles, Eeftens, Marloes, El Marroun, Hanan, Estarlich, Marisa, Gallastegi, Mara, Safont, Llúcia González, Joseph, Wout, Santa-Marina, Loreto, Thielens, Arno, Torrent, Maties, Vrijkotte, Tanja, Wiart, Joe, Röösli, Martin, Cardis, Elisabeth, Vermeulen, Roel, Vrijheid, Martine, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Birks, Laura Ellen, van Wel, Luuk, Liorni, Ilaria, Pierotti, Livia, Guxens, Mònica, Huss, Anke, Foerster, Milena, Capstick, Myles, Eeftens, Marloes, El Marroun, Hanan, Estarlich, Marisa, Gallastegi, Mara, Safont, Llúcia González, Joseph, Wout, Santa-Marina, Loreto, Thielens, Arno, Torrent, Maties, Vrijkotte, Tanja, Wiart, Joe, Röösli, Martin, Cardis, Elisabeth, Vermeulen, Roel, and Vrijheid, Martine
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- 2021
166. Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents
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One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Cabré-Riera, Alba, van Wel, Luuk, Liorni, Ilaria, Thielens, Arno, Birks, Laura Ellen, Pierotti, Livia, Joseph, Wout, González-Safont, Llúcia, Ibarluzea, Jesús, Ferrero, Amparo, Huss, Anke, Wiart, Joe, Santa-Marina, Loreto, Torrent, Maties, Vrijkotte, Tanja, Capstick, Myles, Vermeulen, Roel, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, Guxens, Mònica, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Cabré-Riera, Alba, van Wel, Luuk, Liorni, Ilaria, Thielens, Arno, Birks, Laura Ellen, Pierotti, Livia, Joseph, Wout, González-Safont, Llúcia, Ibarluzea, Jesús, Ferrero, Amparo, Huss, Anke, Wiart, Joe, Santa-Marina, Loreto, Torrent, Maties, Vrijkotte, Tanja, Capstick, Myles, Vermeulen, Roel, Vrijheid, Martine, Cardis, Elisabeth, Röösli, Martin, and Guxens, Mònica
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- 2021
167. Exposure to radiofrequency electromagnetic fields: Comparison of exposimeters with a novel body-worn distributed meter
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IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Huss, Anke, Dongus, Stefan, Aminzadeh, Reza, Thielens, Arno, van den Bossche, Matthias, Van Torre, Patrick, de Seze, René, Cardis, Elisabeth, Eeftens, Marloes, Joseph, Wout, Vermeulen, Roel, Röösli, Martin, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Huss, Anke, Dongus, Stefan, Aminzadeh, Reza, Thielens, Arno, van den Bossche, Matthias, Van Torre, Patrick, de Seze, René, Cardis, Elisabeth, Eeftens, Marloes, Joseph, Wout, Vermeulen, Roel, and Röösli, Martin
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- 2021
168. Radio-frequency electromagnetic field exposure and contribution of sources in the general population: an organ-specific integrative exposure assessment
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One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, van Wel, Luuk, Liorni, Ilaria, Huss, Anke, Thielens, Arno, Wiart, Joe, Joseph, Wout, Röösli, Martin, Foerster, Milena, Massardier-Pilonchery, Amelie, Capstick, Myles, Cardis, Elisabeth, Vermeulen, Roel, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, van Wel, Luuk, Liorni, Ilaria, Huss, Anke, Thielens, Arno, Wiart, Joe, Joseph, Wout, Röösli, Martin, Foerster, Milena, Massardier-Pilonchery, Amelie, Capstick, Myles, Cardis, Elisabeth, and Vermeulen, Roel
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- 2021
169. Onkologie
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Traidl-Hoffmann, Claudia; https://orcid.org/0000-0001-5085-5179, Schulz, Christian, Herrmann, Martin; https://orcid.org/0000-0002-0258-2484, Simon, Babette, Traidl-Hoffmann, C ( Claudia ), Schulz, C ( Christian ), Herrmann, M ( Martin ), Simon, B ( Babette ), Schüz, Joachim; https://orcid.org/0000-0001-9687-2134, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Röösli, Martin; https://orcid.org/0000-0002-7475-1531, Traidl-Hoffmann, Claudia; https://orcid.org/0000-0001-5085-5179, Schulz, Christian, Herrmann, Martin; https://orcid.org/0000-0002-0258-2484, Simon, Babette, Traidl-Hoffmann, C ( Claudia ), Schulz, C ( Christian ), Herrmann, M ( Martin ), Simon, B ( Babette ), Schüz, Joachim; https://orcid.org/0000-0001-9687-2134, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, and Röösli, Martin; https://orcid.org/0000-0002-7475-1531
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- 2021
170. Childhood cancer and residential exposure to highways: a nationwide cohort study
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Spycher, Ben, Feller, Martin, Röösli, Martin, Ammann, Roland, Diezi, Manuel, Egger, Matthias, Kuehni, Claudia, Spycher, Ben, Feller, Martin, Röösli, Martin, Ammann, Roland, Diezi, Manuel, Egger, Matthias, and Kuehni, Claudia
- Abstract
Children living near highways are exposed to higher concentrations of traffic-related carcinogenic pollutants. Several studies reported an increased risk of childhood cancer associated with traffic exposure, but the published evidence is inconclusive. We investigated whether cancer risk is associated with proximity of residence to highways in a nation-wide cohort study including all children aged <16years from Swiss national censuses in 1990 and 2000. Cancer incidence was investigated in time to event analyses (1990-2008) using Cox proportional hazards models and incidence density analyses (1985-2008) using Poisson regression. Adjustments were made for socio-economic factors, ionising background radiation and electromagnetic fields. In time to event analysis based on 532 cases the adjusted hazard ratio for leukaemia comparing children living <100m from a highway with unexposed children (≥500m) was 1.43 (95% CI 0.79, 2.61). Results were similar in incidence density analysis including 1367 leukaemia cases (incidence rate ratio (IRR) 1.57; 95% CI 1.09, 2.25). Associations were similar for acute lymphoblastic leukaemia (IRR 1.64; 95% CI 1.10, 2.43) and stronger for leukaemia in children aged <5years (IRR 1.92; 95% CI 1.22, 3.04). Little evidence of association was found for other tumours. Our study suggests that young children living close to highways are at increased risk of developing leukaemia.
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- 2021
171. Problematic mobile phone use in adolescents: derivation of a short scale MPPUS-10
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Foerster, Milena, Roser, Katharina, Schoeni, Anna, Röösli, Martin, Foerster, Milena, Roser, Katharina, Schoeni, Anna, and Röösli, Martin
- Abstract
Objectives: Our aim was to derive a short version of the Mobile Phone Problem Use Scale (MPPUS) using data from 412 adolescents of the Swiss HERMES (Health Effects Related to Mobile phonE use in adolescentS) cohort. Methods: A German version of the original MPPUS consisting of 27 items was shortened by principal component analysis (PCA) using baseline data collected in 2012. For confirmation, the PCA was carried out again with follow-up data 1year later. Results: PCA revealed four factors related to symptoms of addiction (Loss of Control, Withdrawal, Negative Life Consequences and Craving) and a fifth factor reflecting the social component of mobile phone use (Peer Dependence). The shortened scale (MPPUS-10) highly reflects the original MPPUS (Kendalls' Tau: 0.80 with 90% concordant pairs). Internal consistency of MPPUS-10 was good with Cronbach's alpha: 0.85. The results were confirmed using the follow-up data. Conclusions: The MPPUS-10 is a suitable instrument for research in adolescents. It will help to further clarify the definition of problematic mobile phone use in adolescents and explore similarities and differences to other technological addictions.
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- 2021
172. Brain tumors in children and adolescents and exposure to animals and farm life: a multicenter case–control study (CEFALO)
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Christensen, Jeppe Schultz, Mortensen, Laust Hvas, Röösli, Martin, Feychting, Maria, Tynes, Tore, Andersen, Tina Veje, Schmidt, Lisbeth Samsø, Poulsen, Aslak Harbo, Aydin, Denis, Kuehni, Claudia E., Prochazka, Michaela, Lannering, Birgitta, Klaeboe, Lars, Eggen, Tone, and Schüz, Joachim
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- 2012
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173. Exposure to radiofrequency electromagnetic fields: Comparison of exposimeters with a novel body-worn distributed meter
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Huss, Anke, Dongus, Stefan, Aminzadeh, Reza, Thielens, Arno, van den Bossche, Matthias, Van Torre, Patrick, de Seze, René, Cardis, Elisabeth, Eeftens, Marloes, Joseph, Wout, Vermeulen, Roel, Röösli, Martin, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Institute for Risk Assessment Sciences [Utrecht, The Netherlands] (IRAS), Utrecht University [Utrecht], Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut National de l'Environnement Industriel et des Risques (INERIS), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, and LS IRAS EEPI ME (Milieu epidemiologie)
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Electromagnetic field ,PHONE USE ,Technology and Engineering ,Frequency selectivity ,010504 meteorology & atmospheric sciences ,Radio Waves ,Comparison exposimeters ,010501 environmental sciences ,01 natural sciences ,EME SPY ,Electromagnetic Fields ,Environmental Science(all) ,Background exposure ,Metre ,OUTDOOR ,GE1-350 ,DIFFUSE ,0105 earth and related environmental sciences ,General Environmental Science ,Remote sensing ,CALIBRATION ,Body-Worn Distributed Meter ,ExpoM-RF ,PERSONAL EXPOSURE ,Measurements ,Environmental Exposure ,Environmental sciences ,Spain ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,Microenvironments ,Electromagnetic shielding ,Environmental science ,RF-EMF ,Geometric mean ,Exposure data ,Cell Phone ,Switzerland - Abstract
Background: Exposure to radiofrequency electromagnetic fields (RF-EMF) is often measured with personal exposimeters, but the accuracy of measurements can be hampered as carrying the devices on-body may result in body shielding. Further, the compact design may compromise the frequency selectivity of the sensor. The aim of this study was to compare measurements obtained using a multi-band body-worn distributed-exposimeter (BWDM) with two commercially available personal exposimeters (ExpoM-RF and EmeSpy 200) under real-life conditions. Methods: The BWDM measured power density in 10 frequency bands (800, 900, 1800, 2100, 2600 MHz, DECT 1900 MHz, WiFi 2.4 GHz; with separate uplink/downlink bands for 900, 1800 and 2100 MHz); using 20 separate antennas integrated in a vest and placed on diametrically opposite locations on the body, to minimize body-shielding. RF-EMF exposure data were collected from several microenvironments (e.g. shopping areas, train stations, outdoor rural/ urban residential environments, etc.) by walking around pre-defined areas/routes in Belgium, Spain, France, the Netherlands and Switzerland. Measurements were taken every 1-4 s with the BWDM in parallel with an ExpoM-RF and an EmeSpy 200 exposimeter. We calculated medians and interquartile ranges (IQRs) and compared difference, ratios and correlations of geometric mean RF-EMF exposure levels per microenvironment as measured with the exposimeters and the BWDM. Results: Across 267 microenvironments, medians and IQR of total BWDM measured RF-EMF exposure was 0.13 (0.05-0.33) mW/m2. Difference: IQR of exposimeters minus BWDM exposure levels was -0.011 (-0.049 to 0.0095) mW/m2 for the ExpoM-RF and -0.056 (-0.14 to -0.017) for the EmeSpy 200; ratios (exposimeter/BWDM) of total exposure had an IQR of 0.79 (0.55-1.1) for the ExpoM-RF and 0.29 (0.22-0.38) for the EmeSpy 200. Spearman correlations were 0.93 for the ExpoM-RF vs the BWDM and 0.96 for the EmeSpy 200 vs the BWDM. Discussion and conclusions: Results indicate that exposimeters worn on-body provide somewhat lower total RF-EMF exposure as compared to measurements conducted with the BWDM, in line with effects from body shielding. Ranking of exposure levels of microenvironments showed high correspondence between the different device types. Our results are informative for the interpretation of existing epidemiological research results. Grant Sponsors: This research was funded by the National Research Program of the French Agency for Food, Environmental and Occupational Health and Safety (ANSES), grant No 2015-2-RF-07, and the equipment was supported by funding from the European Commission Seventh Framework Programme under grant agreement number FP7 603794 (GERoNiMO). Our funders had no involvement in the study design; data collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
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- 2020
174. Updating of Swiss noise exposure limits based on WHO's Environmental Noise Guidelines evidence reviews and on results from the SiRENE study
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Brink, Mark, Boegli, Hans, Walker, Urs, Wunderli, Jean Marc, Röösli, Martin, Thomann, Georg, and Swiss Tropical and Public Health Institute [Basel]
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[PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph] ,Noise Exposure ,Limit Values ,WHO Guidelines ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] - Abstract
International audience; The present framework for noise abatement in Switzerland was introduced in the 1980s in the Environmental Protection Act. It was subsequently substantiated with noise exposure limits for a range of noise sources. Due to several recent developments, the empirical foundations of the noise limits were increasingly questioned, especially regarding transportation noise. A working group of the Federal Noise Abatement Commission was appointed and commissioned with the task of updating the pertinent scientific foundations and to suggest revised exposure limits when deemed necessary. One result of these efforts was the launch of the interdisciplinary SiRENE study in 2014 with the aim of deriving up to date exposure-response relationships of health effects representative for the Swiss population. At the same time Switzerland has supported WHO's work on new environmental noise guidelines. In its recommendations regarding new noise exposure limits, the working group took into account exposure-response relationships from the (Switzerland-specific) SiRENE study, from the three WHO evidence reviews for annoyance, for sleep disturbance, and for cardiovascular and metabolic outcomes as well as from a recent update of the latter. In deriving limit values, the group followed a similar heuristic as did the WHO for informing their recommendations, but explicitly considered two classes of effects that were both given the same weight for deriving the limit values: Self-reported ("subjective") effects like annoyance and self-reported sleep disturbances on one hand, and on the other hand ("objective") cardiometabolic effects for which the evidence was considered scientifically sound enough, namely ischaemic heart disease (IHD), diabetes, and myocardial infarction mortality. In order to define acceptable risks for these outcomes, they were weighted with common Disability Weight (DW) values. Further empirical data from the SiRENE study were used to define duration and position of day and night rating periods and time-dependent penalties.
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- 2020
175. Wireless communication fields and non-specific symptoms of ill health: a literature review
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Röösli, Martin and Hug, Kerstin
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- 2011
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176. Temporal trends of radio-frequency electromagnetic field (RF-EMF) exposure in everyday environments across European cities
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Urbinello, Damiano, Joseph, Wout, Verloock, Leen, Martens, Luc, and Röösli, Martin
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- 2014
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177. Modulation of Age- and Cancer-Associated DNA Methylation Change in the Healthy Colon by Aspirin and Lifestyle
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Noreen, Faiza, Röösli, Martin, Gaj, Pawel, Pietrzak, Jakub, Weis, Stefan, Urfer, Patric, Regula, Jaroslaw, Schär, Primo, and Truninger, Kaspar
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- 2014
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178. Exposure to Radio-Frequency Electromagnetic Fields From Broadcast Transmitters and Risk of Childhood Cancer: A Census-based Cohort Study
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Hauri, Dimitri D., Spycher, Ben, Huss, Anke, Zimmermann, Frank, Grotzer, Michael, von der Weid, Nicolas, Spoerri, Adrian, Kuehni, Claudia E., and Röösli, Martin
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- 2014
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179. Association of transportation noise with sleep during infancy: a longitudinal study
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Blume, Christine, primary, Schoch, Sarah Fiona, additional, Vienneau, Danielle, additional, Röösli, Martin, additional, Kohler, Malcolm, additional, Möller, Alexander, additional, Kurth, Salome, additional, and Usemann, Jakob, additional
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- 2021
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180. Relation between organophosphate pesticide metabolite concentrations with pesticide exposures, socio-economic factors and lifestyles: A cross-sectional study among school boys in the rural Western Cape, South Africa
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Molomo, Regina Ntsubise, primary, Basera, Wisdom, additional, Chetty-Mhlanga, Shala, additional, Fuhrimann, Samuel, additional, Mugari, Mufaro, additional, Wiesner, Lubbe, additional, Röösli, Martin, additional, and Dalvie, Mohamed Aqiel, additional
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- 2021
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181. Exposure modeling of high-frequency electromagnetic fields
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Bürgi, Alfred, Theis, Gaston, Siegenthaler, Andreas, and Röösli, Martin
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- 2008
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182. Comparing Methods to Impute Missing Daily Ground-Level PM10 Concentrations between 2010–2017 in South Africa
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Arowosegbe, Oluwaseyi Olalekan, primary, Röösli, Martin, additional, Künzli, Nino, additional, Saucy, Apolline, additional, Adebayo-Ojo, Temitope Christina, additional, Jeebhay, Mohamed F., additional, Dalvie, Mohammed Aqiel, additional, and de Hoogh, Kees, additional
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- 2021
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183. Comment on Choi, Y.-J., et al. Cellular Phone Use and Risk of Tumors: Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2020, 17, 8079
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de Vocht, Frank, primary and Röösli, Martin, additional
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- 2021
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184. Residential radon – Comparative analysis of exposure models in Switzerland
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Vienneau, Danielle, primary, Boz, Seçkin, additional, Forlin, Lukas, additional, Flückiger, Benjamin, additional, de Hoogh, Kees, additional, Berlin, Claudia, additional, Bochud, Murielle, additional, Bulliard, Jean-Luc, additional, Zwahlen, Marcel, additional, and Röösli, Martin, additional
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- 2021
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185. Effect of breastfeeding duration on lung function, respiratory symptoms and allergic diseases in school-age children
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Gorlanova, Olga, Appenzeller, Rhea, Mahmoud, Yasmin S, Ramsey, Kathryn A, Usemann, Jakob, Decrue, Fabienne, Kuehni, Claudia E, Röösli, Martin, Latzin, Philipp, Fuchs, Oliver, Soti, Andras, Frey, Urs, University of Zurich, and Frey, Urs
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2740 Pulmonary and Respiratory Medicine ,610 Medicine & health ,2735 Pediatrics, Perinatology and Child Health ,10178 Clinic for Pneumology ,360 Social problems & social services ,respiratory tract diseases - Abstract
BACKGROUND A positive effect of breastfeeding on lung function has been demonstrated in cohorts of children with asthma or risk for asthma. We assessed the impact of breastfeeding on lung function and symptoms at the age of 6 years in an unselected, healthy birth cohort. METHODS We prospectively studied healthy term infants from the Bern-Basel Infant Lung Development (BILD) cohort from birth up to 6 years. Any breastfeeding was assessed by weekly phone calls during the first year of life. Risk factors (eg, smoking exposure, parental history of allergic conditions, and education) were obtained using standardized questionnaires. The primary outcomes were lung function parameters measured at 6 years of age by spirometry forced expiratory volume in 1 second, body plethysmography (functional residual capacity [FRCpleth ], the total lung capacity [TLCpleth ], and the effective respiratory airway resistance [Reff ]) and fractional exhaled nitric oxide (FeNO). Secondary outcomes included ever wheeze (between birth and 6 years), wheeze in the past 12 months, asthma, presence of allergic conditions, atopic dermatitis, rhinitis, and positive skin prick test at the age of 6 years. RESULTS In 377 children the mean breastfeeding duration was 36 weeks (SD 14.4). We found no association of breastfeeding duration with obstructive or restrictive lung function and FeNO. After adjustment for confounders, we found no associations of breastfeeding duration with respiratory symptoms or the presence of allergic conditions. CONCLUSION This study found no evidence of an association between breastfeeding and comprehensive lung function in unselected healthy children with long-term breastfeeding. Our findings do not support the hypothesis that the duration of breastfeeding has a direct impact on lung function in a healthy population with low asthmatic risk.
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- 2020
186. Increase in Airway Obstruction between 1993 and 2012 in Switzerland. An Observational Study
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West, Erin A, Strassmann, Alexandra, Wang, Craig, Turk, Alexander, de Hoogh, Kees, Röösli, Martin, Bopp, Matthias, Buist, A Sonia, Dressel, Holger, Puhan, Milo A, University of Zurich, and Puhan, Milo A
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Pulmonary and Respiratory Medicine ,2740 Pulmonary and Respiratory Medicine ,610 Medicine & health ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) - Published
- 2020
187. Guidelines for Limiting Exposure to Electromagnetic Fields (100 kHz to 300 GHz)
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Ziegelberger, Gunde, Croft, Rodney, Feychting, Maria, Green, Adèle C., Hirata, Akimasa, d'Inzeo, Guglielmo, Jokela, Kari, Loughran, Sarah, Marino, Carmela, Miller, Sharon, Oftedal, Gunnhild, Okuno, Tsutomu, van Rongen, Eric, Röösli, Martin, Sienkiewicz, Zenon, Tattersall, John E.H., and Watanabe, Soichi
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Radiation, Nonionizing ,radio-frequency ,EM fields ,Epidemiology ,Health, Toxicology and Mutagenesis ,Guidelines as Topic ,Radiation Dosage ,microwaves ,Electromagnetic Fields ,Radiation Protection ,safety standard ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiation Injuries - Abstract
Radiofrequency electromagnetic fields (EMFs) are used to enable a number of modern devices, including mobile telecommunications infrastructure and phones, Wi-Fi, and Bluetooth. As radiofrequency EMFs at sufficiently high power levels can adversely affect health, ICNIRP published Guidelines in 1998 for human exposure to time-varying EMFs up to 300 GHz, which included the radiofrequency EMF spectrum. Since that time, there has been a considerable body of science further addressing the relation between radiofrequency EMFs and adverse health outcomes, as well as significant developments in the technologies that use radiofrequency EMFs. Accordingly, ICNIRP has updated the radiofrequency EMF part of the 1998 Guidelines. This document presents these revised Guidelines, which provide protection for humans from exposure to EMFs from 100 kHz to 300 GHz. Health Phys. 118(5):483–524; 2020. Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Health Physics Society. This is an open-access article distributed under the terms of the Creative Commons AttributionNon Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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- 2020
188. Occupational exposure and the risk of airway obstruction and mortality
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Strassmann, Alexandra, Kaufmann, Marco, Dressel, Holger, Turk, Alexander, Röösli, Martin, de Hoogh, Kees, Sadhra, Steven S, Bopp, Matthias, Puhan, Milo A, University of Zurich, and Puhan, Milo A
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Interaction ,Environmental and Occupational Health ,610 Medicine & health ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,2739 Public Health, Environmental and Occupational Health ,Public Health ,Airway obstruction ,Mortality ,Industries ,Health(social science) ,Occupational exposure - Published
- 2020
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189. Temporal variation of pesticide mixtures in rivers of three agricultural watersheds during a major drought in the Western Cape, South Africa
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Curchod, Lou, Oltramare, Christelle, Junghans, Marion, Stamm, Christian, Dalvie, Mohamed Aqiel, Röösli, Martin, Fuhrimann, Samuel, One Health Chemisch, and dIRAS RA-2
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sustainable development goal 6 ,climate change ,passive water sampling ,surface water ,drought ,pesticide - Abstract
South Africa is the leading pesticide user in Sub-Saharan Africa. However, little is known about the occurrence of pesticide mixtures in surface water and potential environmental risks in Africa. This study investigated the occurrence of pesticides mixtures in three watersheds during a drought year in South Africa. The study was conducted in the Krom River, Berg River and Hex River watersheds within larger agriculture systems in the Western Cape. Pesticide spray records were collected from 38 farms. A total of 21 passive water samplers (styrenedivinylbenzene disks (SDB)) were deployed, each for two weeks per month, over seven sampling rounds during the main pesticide application period between July 2017 and January 2018. Samples were analyzed for 248 pesticide compounds using LC-HR-MS/MS. Pesticide occurrence was analyzed for temporal agreement with pesticide spraying events (Cohen's κ) and correlation with rainfall patterns and river discharge (Pearson correlation (r p )). Pesticide time-weighted average concentrations were estimated and compared to environmental quality standards (EQS). According to the farm spray records, 96 different pesticides were sprayed during the sampling period and differed considerably between the three study areas, seasons and crops grown. In total, 53 compounds were detected in river water. We detected 39% of compounds from the spraying records and demonstrated close temporal correlations of seasonal patterns for 11 pesticide compounds between reported on spraying records and observations in the streams (κ = 0.90). However, 23 detected pesticides were not found on spray records, many of them being herbicides. Most of the estimated two-week average pesticide concentrations were below 40 ng/L. The insecticides imidacloprid, thiacloprid, chlorpyrifos and acetamiprid and the herbicide terbuthylazine exceeded at least once their EQS 58-fold (EQS 13 ng/L), 12-fold (EQS 10 ng/L), 9-fold (EQS 0.46 ng/L), 5-fold (EQS 24 ng/L) and 3-fold (EQS 220 ng/L), respectively. Our study substantially widens the view on pesticide pollution in surface water compared to previous studies in Sub-Saharan Africa by targeting more than 200 pesticides using passive sampling systems. This broad assessment revealed the presence of 53 compounds, some of them in high concentrations, indicating possible adverse effects on biota and the quality of the ecosystem. Whether the observed concentration levels in the year 2017 were exceptional due to the lowest ever recorded rainfall and river discharge needs to be tested with additional data to better understand how pesticide pollution levels manifest under average rainfall and river discharge conditions.
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- 2020
190. Estimated whole-brain and lobe-specific radiofrequency electromagnetic fields doses and brain volumes in preadolescents
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Cabré-Riera, Alba, Marroun, Hanan El, Muetzel, Ryan, van Wel, Luuk, Liorni, Ilaria, Thielens, Arno, Birks, Laura Ellen, Pierotti, Livia, Huss, Anke, Joseph, Wout, Wiart, Joe, Capstick, Myles, Hillegers, Manon, Vermeulen, Roel, Cardis, Elisabeth, Vrijheid, Martine, White, Tonya, Röösli, Martin, Tiemeier, Henning, Guxens, Mònica, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Department of Psychology [Minneapolis], University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, Universiteit Gent = Ghent University [Belgium] (UGENT), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Clinical Psychology, Pediatrics, Child and Adolescent Psychiatry / Psychology, Radiology & Nuclear Medicine, and Erasmus MC other
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010504 meteorology & atmospheric sciences ,Wireless technology ,[SDV]Life Sciences [q-bio] ,CHILDREN ,010501 environmental sciences ,Audiology ,01 natural sciences ,Child development ,Telecommunications ,Cell phone use ,Telephone ,Neuroimaging ,Electromagnetic fields ,Radio waves ,Brain ,ADOLESCENTS ,Medicine ,Lead (electronics) ,Child ,fields ,lcsh:Environmental sciences ,General Environmental Science ,Netherlands ,MOBILE PHONE USE ,lcsh:GE1-350 ,education.field_of_study ,3. Good health ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,Generation R ,medicine.medical_specialty ,animal structures ,Technology and Engineering ,Population ,Temporal lobe ,SLEEP EEG ,Humans ,EXPOSURE ,education ,0105 earth and related environmental sciences ,business.industry ,MEMORY ,Digital Enhanced Cordless Telecommunications ,Environmental Exposure ,PERFORMANCE ,COGNITIVE FUNCTION ,Electromagnetic ,Cross-Sectional Studies ,Mobile phone ,MORPHOLOGY ,RADIATION ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Mobile telephony ,business ,Cell Phone - Abstract
Objective: To assess the association between estimated whole-brain and lobe-specific radiofrequency electromagnetic fields (RF-EMF) doses, using an improved integrated RF-EMF exposure model, and brain volumes in preadolescents at 9–12 years old. Methods: Cross-sectional analysis in preadolescents aged 9–12 years from the Generation R Study, a population-based birth cohort set up in Rotterdam, The Netherlands (n = 2592). An integrated exposure model was used to estimate whole-brain and lobe-specific RF-EMF doses (mJ/kg/day) from different RF-EMF sources including mobile and Digital Enhanced Cordless Telecommunications (DECT) phone calls, other mobile phone uses than calling, tablet use, laptop use, and far-field sources. Whole-brain and lobe-specific RF-EMF doses were estimated for all RF-EMF sources together (i.e. overall) and for three groups of RF-EMF sources that lead to a different pattern of RF-EMF exposure. Information on brain volumes was extracted from magnetic resonance imaging scans. Results: Estimated overall whole-brain RF-EMF dose was 84.3 mJ/kg/day. The highest overall lobe-specific dose was estimated in the temporal lobe (307.1 mJ/kg/day). Whole-brain and lobe-specific RF-EMF doses from all RF-EMF sources together, from mobile and DECT phone calls, and from far-field sources were not associated with global, cortical, or subcortical brain volumes. However, a higher whole-brain RF-EMF dose from mobile phone use for internet browsing, e-mailing, and text messaging, tablet use, and laptop use while wirelessly connected to the internet was associated with a smaller caudate volume. Conclusions: Our results suggest that estimated whole-brain and lobe-specific RF-EMF doses were not related to brain volumes in preadolescents at 9–12 years old. Screen activities with mobile communication devices while wirelessly connected to the internet lead to low RF-EMF dose to the brain and our observed association may thus rather reflect effects of social or individual factors related to these specific uses of mobile communication devices. However, we cannot discard residual confounding, chance finding, or reverse causality. Further studies on mobile communication devices and their potential negative associations with brain development are warranted, regardless whether associations are due to RF-EMF exposure or to other factors related to their use.
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- 2020
191. A genome-wide association study on medulloblastoma
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Dahlin, Anna M., Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M., Scheurer, Michael E., Lau, Ching C., McKean-Cowdin, Roberta, Kennedy, Rebekah J., Hung, Long T., Yee, Janis, Margol, Ashley S., Barrington-Trimis, Jessica, Gauderman, W. James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Prochazka, Michaela, Adel Fahmideh, Maral, Lannering, Birgitta, Schmidt, Lisbeth S., Johansen, Christoffer, Sehested, Astrid, Kuehni, Claudia, Grotzer, Michael, Tynes, Tore, Eggen, Tone, Klaeboe, Lars, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, and Melin, Beatrice S.
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Cancer Research ,Genotype ,Neurologi ,Epidemiology ,Pediatric cancers ,Genome-wide association study ,Biology ,Polymorphism, Single Nucleotide ,Germline ,Cohort Studies ,Biomarkers, Tumor ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetics of risk, outcome, and prevention ,Cerebellar Neoplasms ,neoplasms ,Genetics ,Medulloblastoma ,CNS cancers ,Cancer och onkologi ,Genetic variants ,Adolescents and young adults (AYA) ,Prognosis ,medicine.disease ,and prevention ,Genetics of risk ,Oncology ,Neurology ,Case-Control Studies ,Cancer and Oncology ,Laboratory Investigation ,outcome ,Neurology (clinical) ,Genome-Wide Association Study - Abstract
Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark. Methods Genotyping was performed using Illumina BeadChips, and untyped variants were imputed using IMPUTE2. Results Fifty-nine variants in 11 loci were associated with increased medulloblastoma risk (p –5), but none were statistically significant after adjusting for multiple testing (p –8). Thirteen of these variants were genotyped, whereas 46 were imputed. Genotyped variants were further investigated in a validation study comprising 249 medulloblastoma cases and 629 control subjects. In the validation study, rs78021424 (18p11.23, PTPRM) was associated with medulloblastoma risk with OR in the same direction as in the discovery cohort (ORT = 1.59, pvalidation = 0.02). We also selected seven medulloblastoma predisposition genes for investigation using a candidate gene approach: APC, BRCA2, PALB2, PTCH1, SUFU, TP53, and GPR161. The strongest evidence for association was found for rs201458864 (PALB2, ORT = 3.76, p = 3.2 × 10–4) and rs79036813 (PTCH1, ORA = 0.42, p = 2.6 × 10–3). Conclusion The results of this study, including a novel potential medulloblastoma risk loci at 18p11.23, are suggestive but need further validation in independent cohorts.
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- 2020
192. Magnetic field exposure and neurodegenerative diseases – recent epidemiological studies
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Hug, Kerstin, Röösli, Martin, and Rapp, Regula
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- 2006
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193. The prevalence of symptoms attributed to electromagnetic field exposure: a cross-sectional representative survey in Switzerland
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Schreier, Nadja, Huss, Anke, and Röösli, Martin
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- 2006
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194. Short term association between ozone and mortality : global two stage time series study in 406 locations in 20 countries
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Vicedo-Cabrera, Ana M, Sera, Francesco, Liu, Cong, Armstrong, Ben, Milojevic, Ai, Guo, Yuming, Tong, Shilu, Lavigne, Eric, Kyselý, Jan, Urban, Aleš, Orru, Hans, Indermitte, Ene, Pascal, Mathilde, Huber, Veronika, Schneider, Alexandra, Katsouyanni, Klea, Samoli, Evangelia, Stafoggia, Massimo, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Ng, Chris Fook Sheng, Hurtado-Diaz, Magali, Cruz, Julio, Silva, Susana, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M, Kim, Ho, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S, Röösli, Martin, Guo, Yue-Liang Leon, Chen, Bing-Yu, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L, Kan, Haidong, Gasparrini, Antonio, Vicedo-Cabrera, Ana M, Sera, Francesco, Liu, Cong, Armstrong, Ben, Milojevic, Ai, Guo, Yuming, Tong, Shilu, Lavigne, Eric, Kyselý, Jan, Urban, Aleš, Orru, Hans, Indermitte, Ene, Pascal, Mathilde, Huber, Veronika, Schneider, Alexandra, Katsouyanni, Klea, Samoli, Evangelia, Stafoggia, Massimo, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Ng, Chris Fook Sheng, Hurtado-Diaz, Magali, Cruz, Julio, Silva, Susana, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M, Kim, Ho, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S, Röösli, Martin, Guo, Yue-Liang Leon, Chen, Bing-Yu, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L, Kan, Haidong, and Gasparrini, Antonio
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OBJECTIVE: To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide. DESIGN: Two stage time series analysis. SETTING: 406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network. POPULATION: Deaths for all causes or for external causes only registered in each city within the study period. MAIN OUTCOME MEASURES: Daily total mortality (all or non-external causes only). RESULTS: A total of 45 165 171 deaths were analysed in the 406 cities. On average, a 10 µg/m3 increase in ozone during the current and previous day was associated with an overall relative risk of mortality of 1.0018 (95% confidence interval 1.0012 to 1.0024). Some heterogeneity was found across countries, with estimates ranging from greater than 1.0020 in the United Kingdom, South Africa, Estonia, and Canada to less than 1.0008 in Mexico and Spain. Short term excess mortality in association with exposure to ozone higher than maximum background levels (70 µg/m3) was 0.26% (95% confidence interval 0.24% to 0.28%), corresponding to 8203 annual excess deaths (95% confidence interval 3525 to 12 840) across the 406 cities studied. The excess remained at 0.20% (0.18% to 0.22%) when restricting to days above the WHO guideline (100 µg/m3), corresponding to 6262 annual excess deaths (1413 to 11 065). Above more lenient thresholds for air quality standards in Europe, America, and China, excess mortality was 0.14%, 0.09%, and 0.05%, respectively. CONCLUSIONS: Results suggest that ozone related mortality could be potentially reduced under stricter air quality standards. These findings have relevance for the implementation of efficient clean air interventions and mitigation strategies designed within national and international climate policies.
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- 2020
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195. Estimated whole-brain and lobe-specific radiofrequency electromagnetic fields doses and brain volumes in preadolescents
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One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Cabré-Riera, Alba, Marroun, Hanan El, Muetzel, Ryan, van Wel, Luuk, Liorni, Ilaria, Thielens, Arno, Birks, Laura Ellen, Pierotti, Livia, Huss, Anke, Joseph, Wout, Wiart, Joe, Capstick, Myles, Hillegers, Manon, Vermeulen, Roel, Cardis, Elisabeth, Vrijheid, Martine, White, Tonya, Röösli, Martin, Tiemeier, Henning, Guxens, Mònica, One Health Chemisch, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Cabré-Riera, Alba, Marroun, Hanan El, Muetzel, Ryan, van Wel, Luuk, Liorni, Ilaria, Thielens, Arno, Birks, Laura Ellen, Pierotti, Livia, Huss, Anke, Joseph, Wout, Wiart, Joe, Capstick, Myles, Hillegers, Manon, Vermeulen, Roel, Cardis, Elisabeth, Vrijheid, Martine, White, Tonya, Röösli, Martin, Tiemeier, Henning, and Guxens, Mònica
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- 2020
196. Temporal variation of pesticide mixtures in rivers of three agricultural watersheds during a major drought in the Western Cape, South Africa
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One Health Chemisch, dIRAS RA-2, Curchod, Lou, Oltramare, Christelle, Junghans, Marion, Stamm, Christian, Dalvie, Mohamed Aqiel, Röösli, Martin, Fuhrimann, Samuel, One Health Chemisch, dIRAS RA-2, Curchod, Lou, Oltramare, Christelle, Junghans, Marion, Stamm, Christian, Dalvie, Mohamed Aqiel, Röösli, Martin, and Fuhrimann, Samuel
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- 2020
197. A genome-wide association study on medulloblastoma.
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Dahlin, Anna M, Dahlin, Anna M, Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M, Scheurer, Michael E, Lau, Ching C, McKean-Cowdin, Roberta, Kennedy, Rebekah J, Hung, Long T, Yee, Janis, Margol, Ashley S, Barrington-Trimis, Jessica, Gauderman, W James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Cefalo Study Group, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, Melin, Beatrice, Dahlin, Anna M, Dahlin, Anna M, Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M, Scheurer, Michael E, Lau, Ching C, McKean-Cowdin, Roberta, Kennedy, Rebekah J, Hung, Long T, Yee, Janis, Margol, Ashley S, Barrington-Trimis, Jessica, Gauderman, W James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Cefalo Study Group, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, and Melin, Beatrice
- Abstract
IntroductionMedulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.MethodsGenotyping was performed using Illumina BeadChips, and untyped variants were imputed using IMPUTE2.ResultsFifty-nine variants in 11 loci were associated with increased medulloblastoma risk (p < 1 × 10-5), but none were statistically significant after adjusting for multiple testing (p < 5 × 10-8). Thirteen of these variants were genotyped, whereas 46 were imputed. Genotyped variants were further investigated in a validation study comprising 249 medulloblastoma cases and 629 control subjects. In the validation study, rs78021424 (18p11.23, PTPRM) was associated with medulloblastoma risk with OR in the same direction as in the discovery cohort (ORT = 1.59, pvalidation = 0.02). We also selected seven medulloblastoma predisposition genes for investigation using a candidate gene approach: APC, BRCA2, PALB2, PTCH1, SUFU, TP53, and GPR161. The strongest evidence for association was found for rs201458864 (PALB2, ORT = 3.76, p = 3.2 × 10-4) and rs79036813 (PTCH1, ORA = 0.42, p = 2.6 × 10-3).ConclusionThe results of this study, including a novel potential medulloblastoma risk loci at 18p11.23, are suggestive but need further validation in independent cohorts.
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- 2020
198. Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries
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Ministerio de Economía y Competitividad (España), Tobías, Aurelio [0000-0001-6428-6755], Vicedo-Cabrera, Ana M., Sera, Francesco, Liu, Cong, Armstrong, Ben, Milojevic, Ai, Guo, Yuming, Tong, Shilu, Lavigne, Eric, Kyselý, Jan, Urban, Aleš, Orru, Hans, Indermitte, Ene, Pascal, Mathilde, Huber, Veronika, Schneider, Alexandra, Katsouyanni, Klea, Samoli, Evangelia, Stafoggia, Massimo, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Sheng Ng, Chris Fook, Hurtado-Díaz, Magali, Cruz, Julio, Silva, Susana, Madureira, Joana, Scovronick, Noah, Garland, Rebeca M., Kim, Ho, Tobías, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Röösli, Martin, Leon Guo, Yue-Liang, Chen, Bing-Yu, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Kan, Haidong, Gasparrini, Antonio, Ministerio de Economía y Competitividad (España), Tobías, Aurelio [0000-0001-6428-6755], Vicedo-Cabrera, Ana M., Sera, Francesco, Liu, Cong, Armstrong, Ben, Milojevic, Ai, Guo, Yuming, Tong, Shilu, Lavigne, Eric, Kyselý, Jan, Urban, Aleš, Orru, Hans, Indermitte, Ene, Pascal, Mathilde, Huber, Veronika, Schneider, Alexandra, Katsouyanni, Klea, Samoli, Evangelia, Stafoggia, Massimo, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Sheng Ng, Chris Fook, Hurtado-Díaz, Magali, Cruz, Julio, Silva, Susana, Madureira, Joana, Scovronick, Noah, Garland, Rebeca M., Kim, Ho, Tobías, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Röösli, Martin, Leon Guo, Yue-Liang, Chen, Bing-Yu, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Kan, Haidong, and Gasparrini, Antonio
- Abstract
Objective To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide. Design Two stage time series analysis. Setting 406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network. Population Deaths for all causes or for external causes only registered in each city within the study period. Main outcome measures Daily total mortality (all or non-external causes only). Results A total of 45 165 171 deaths were analysed in the 406 cities. On average, a 10 µg/m3 increase in ozone during the current and previous day was associated with an overall relative risk of mortality of 1.0018 (95% confidence interval 1.0012 to 1.0024). Some heterogeneity was found across countries, with estimates ranging from greater than 1.0020 in the United Kingdom, South Africa, Estonia, and Canada to less than 1.0008 in Mexico and Spain. Short term excess mortality in association with exposure to ozone higher than maximum background levels (70 µg/m3) was 0.26% (95% confidence interval 0.24% to 0.28%), corresponding to 8203 annual excess deaths (95% confidence interval 3525 to 12 840) across the 406 cities studied. The excess remained at 0.20% (0.18% to 0.22%) when restricting to days above the WHO guideline (100 µg/m3), corresponding to 6262 annual excess deaths (1413 to 11 065). Above more lenient thresholds for air quality standards in Europe, America, and China, excess mortality was 0.14%, 0.09%, and 0.05%, respectively. Conclusions Results suggest that ozone related mortality could be potentially reduced under stricter air quality standards. These findings have relevance for the implementation of efficient clean air interventions and mitigation strategies designed within national and international climate policies.
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- 2020
199. Increase in Airway Obstruction between 1993 and 2012 in Switzerland. An Observational Study
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West, Erin A; https://orcid.org/0000-0001-7339-3819, Strassmann, Alexandra, Wang, Craig, Turk, Alexander, de Hoogh, Kees, Röösli, Martin, Bopp, Matthias, Buist, A Sonia, Dressel, Holger, Puhan, Milo A, West, Erin A; https://orcid.org/0000-0001-7339-3819, Strassmann, Alexandra, Wang, Craig, Turk, Alexander, de Hoogh, Kees, Röösli, Martin, Bopp, Matthias, Buist, A Sonia, Dressel, Holger, and Puhan, Milo A
- Abstract
Rationale: Most studies determining the prevalence of airway obstruction are limited to short time periods.Objectives: Because temporal trends of obstruction in populations are largely unknown, we determined the prevalence of airway obstruction over 20 years in yearly general population samples in Switzerland between 1993 and 2012.Methods: We analyzed data of 85,789 participants aged 35 years and older who provided spirometric measurements as part of the LuftiBus lung function campaign. We linked data from the 2003-2012 period to the Swiss National Cohort to adjust for annual population differences. Spirometry was performed without bronchodilation, according to American Thoracic Society guidelines. We used Global Lung Initiative (GLI) and Hankinson reference equations to identify obstruction.Results: Obstruction prevalence increased between 1993 and 2012 from 6.1% (95% confidence interval [CI], 5.5 to 6.7) to 15.6% (95% CI, 13.8 to 17.3) based on GLI estimates and from 5.3% (95% CI, 4.7 to 5.9) to 15.4% (95% CI, 13.6 to 17.1) based on Hankinson estimates. When adjusted for participant demographics, air pollutant and occupational exposures, altitude, and season, the prevalence ratios of obstruction were 1.54 (95% CI, 1.22 to 1.93) and 1.65 (95% CI, 1.33 to 2.04) for GLI- and Hankinson-defined airway obstruction, respectively, for 2012 compared with 2003.Conclusions: Though prebronchodilator measurements likely overestimate the prevalence of airway obstruction in absolute terms compared with post-bronchodilator measurements, we found an increase in airway obstruction prevalence. Even with adjustment for several well-known risk factors for obstruction to make the populations across the years more comparable, we still saw a statistically significant increase in prevalence over this time period.
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- 2020
200. Sleep disturbances in the vicinity of the short-wave broadcast transmitter schwarzenburg
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Abelin, Theodor, Altpeter, Ekkehardt, and Röösli, Martin
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- 2005
- Full Text
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