Search

Your search keyword '"Rivkees, Scott A."' showing total 747 results
Start Over Author "Rivkees, Scott A."
747 results on '"Rivkees, Scott A."'

167. The Role of Propylthiouracil in the Management of Graves' Disease in Adults: Report of a Meeting Jointly Sponsored by the American Thyroid Association and the Food and Drug Administration

Author

Bahn, Rebecca S., primary, Burch, Henry S., additional, Cooper, David S., additional, Garber, Jeffrey R., additional, Greenlee, Carol M., additional, Klein, Irwin L., additional, Laurberg, Peter, additional, McDougall, I. Ross, additional, Rivkees, Scott A., additional, Ross, Douglas, additional, Sosa, Julie Ann, additional, and Stan, Marius N., additional

Published
2009
Full Text
View/download PDF

178. Colaboradores

Author

Backeljauw, Philippe F., Battelino, Tadej, Bondy, Carolyn A., Chandler, Donald Walt, Chia, Dennis J., Chun, Kelly Y., Cohen, Pinchas, Cooke, David W., Couch, Sarah C., Daniels, Stephen R., Dattani, Mehul Tulsidas, De León, Diva D., Deladoëy, Johnny, Diamond, Frank B., Jr., Dunkel, Leo, Flück, Christa E., Haller, Michael J., Kublaoui, Bassil, Langdon, David R., Lee, Peter A., Levine, Michael A., Lustig, Robert H., Majzoub, Joseph A., Menon, Ram K., Miller, Walter L., Muglia, Louis J., Nakamoto, Jon, Palmert, Mark R., Pepkowitz, Samuel H., Phillip, Moshe, Radovick, Sally, Rapaport, Robert, Rivkees, Scott A., Root, Allen W., Rosenfeld, Ron G., Rosenfield, Robert L., Saenger, Paul, Schatz, Desmond A., Sperling, Mark A., Srivatsa, Abhinash, Stanley, Charles A., Stratakis, Constantine A., Tamborlane, William V., Thornton, Paul S., Trucco, Massimo, Vliet, Guy Van, Waguespack, Steven G., Weinzimer, Stuart A., Weiss, Ram, Winter, William E., Witchel, Selma Feldman, and Ying, Anita K.

Published
2015
Full Text
View/download PDF

179. Book Review Pediatric Endocrinology, Volume 1: Obesity, Diabetes Mellitus, Insulin Resistance, and Hypoglycemia Fifth edition. Edited by Fima Lifshitz. 1297 pp., in two volumes, illustrated. New York, Informa Healthcare, 2007. $349.95. 978-1-4200-4271-9 (Vol. 1 ISBN, 978-0-8493-4068-0; Vol. 2 ISBN, 978-1-4200-4270-2.) Pediatric Endocrinology, Volume 2: Growth, Adrenal, Sexual, Thyroid, Calcium, and Fluid Balance Disorders Pediatric Endocrinology, Volume 2: Growth, Adrenal, Sexual, Thyroid, Calcium, and Fluid Balance Disorders

Author

Rivkees, Scott A., primary

Published
2007
Full Text
View/download PDF

181. cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes.

Author

Xiefan Fang, Robinson, Jourdon, Wang-Hu, John, Lingli Jiang, Freeman, Daniel A., Rivkees, Scott A., and Wendler, Christopher C.

Subjects
CYCLIC adenylic acid, HEART cells, CELL lines, PHOSPHODIESTERASES, GENE expression, CARDIOMYOPATHIES
Abstract

cAMP is a highly regulated secondary messenger involved in many biological processes. Chronic activation of the cAMP pathway by catecholamines results in cardiac hypertrophy and fibrosis; however, the mechanism by which elevated cAMP leads to cardiomyopathy is not fully understood. To address this issue, we increased intracellular cAMP levels in HL-1 cardiomyocytes, a cell line derived from adult mouse atrium, using either a stable cAMP analog N6,2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (DB-cAMP), or phosphodiesterase (PDE) inhibitors, caffeine and theophylline. Elevated cAMP levels increased cell size and altered expression levels of cardiac genes and microRNAs associated with hypertrophic cardiomyopathy (HCM), including Myh6, Myh7, Myh7b, Tnni3, Anp, Bnp, Gata4, Mef2c, Mef2d, Nfatc1, miR208a, and miR208b. In addition, DB-cAMP altered the expression of DNA methyltransferases (Dnmts) and TET methylcytosine dioxygenases (Tets), enzymes that regulate genomic DNA methylation levels. Changes in expression of DNA methylation genes induced by elevated cAMP led to increased global DNA methylation in HL-1 cells. In contrast, inhibition of DNMT activity with 5-azacytidine treatment decreased global DNA methylation levels and blocked the increased expression of several HCM genes (Myh7, Gata4, Mef2c, Nfatc1, Myh7b, Tnni3, and Bnp) observed with DB-cAMP treatment. These results demonstrate that cAMP induces cardiomyocyte hypertrophy and altered HCM gene expression in vitro and that DNA methylation patterns mediate the up-regulation of HCM genes induced by cAMP. These data identify a previously unknown mechanism by which elevated levels of cAMP lead to increased expression of genes associated with cardiomyocyte hypertrophy. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

190. Rest-activity patterns in children with hypopituitarism

Author

Rivkees, Scott A.

Subjects
Hypopituitarism -- Physiological aspects, Hypopituitarism -- Research, Circadian rhythms -- Analysis
Abstract

Objectives. Physical lesions in the region of the suprachiasmatic nuclei, which are the site of a circadian clock, result in abnormal circadian rhythmicity in animals, yet the extent of biological rhythm problems in individuals with anatomic or functional lesions in the hypothalamic-pituitary region are largely unknown. To address this issue, we examined patterns of rest and activity of children with hypopituitarism. Methods. Children who were between the ages of 2 and 18 years and had the diagnosis of panhypopituitarism were evaluated. Twenty children were studied, including children with septo-optic dysplasia (SOD), congenital hypopituitarism, brain tumors, closed head trauma, and head irradiation. For assessing patterns of activity, individuals wore Actiwatches for 3-4 weeks to measure patterns of gross motor activity. Results. Seventeen children had normal patterns of rest and activity, with an average period length of 24.01 [+ or -] 0.01 hours. Three children, including 2 with SOD and 1 with a hypothalamic germinoma, showed abnormal activity patterns in which there was not consolidated rest at night. One patient with an optic glioma had nonentrained circadian phase. Conclusions. A proportion of children with hypopituitarism have abnormal daily rest-activity patterns. Children with anterior hypothalamic tumors and SOD seem to be at risk for circadian system dysfunction. Pediatrics 2003;111:e720-e724. URL: http://www.pediatrics. org/cgi/content/full/111/6/e720; septo-optic dysplasia, actigraphy, pediatric circadium rhythm, hypopituitarism.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results