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2,138 results on '"Rico, M"'

155. PO-1287: Quality of life (QL) in elderly breast cancer survivors. Effects of surgery. Global QL determinants

Author

Arraras, J.I., primary, Manterola, A., additional, Illarramendi, J.J., additional, Asin, G., additional, Campo, M., additional, De la Cruz, S., additional, Zarandona, U., additional, Ibañez, B., additional, Rico, M., additional, Salgado, E., additional, Dominguez, M.A., additional, Barrado, M., additional, and Martinez, E., additional

Published
2020
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157. Quality of life (QL) in elderly breast cancer survivors. Effects of surgery. Global QL determinants

Author

Arraras, J.I., primary, Illarramendi, J.J., additional, Manterola, A., additional, De la Cruz, S., additional, Asin, G., additional, Salgado, E., additional, Campos, M., additional, Barrado, M., additional, Ibañez, B., additional, Zarandona, U., additional, Rico, M., additional, Dominguez, M.A., additional, Sola, A., additional, and Martinez, E., additional

Published
2020
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159. Comparación de técnicas ventilatorias ante el daño pulmonar inducido en modelo de cerdo recién nacido

Author

Abella, Pilar, Badía, Martín, Beltrán, M. Belén, Cabral, Tamara, Farías, Lucía, Rico, M. Agustina, Fernández, Cecilia, Vaamonde, Lucía, Blasina, Fernanda, Abella Pilar, Universidad de la República (Uruguay), Facultad de Medicina, Badía Martín, Universidad de la República (Uruguay), Facultad de Medicina, Beltrán M. Belén, Universidad de la República (Uruguay), Facultad de Medicina, Cabral Tamara, Universidad de la República (Uruguay), Facultad de Medicina, Farías Lucía, Universidad de la República (Uruguay), Facultad de Medicina, Rico M. Agustina, Universidad de la República (Uruguay), Facultad de Medicina, Fernández Cecilia, Universidad de la República (Uruguay), Facultad de Medicina, Vaamonde Lucía, Universidad de la República (Uruguay), Facultad de Medicina, and Blasina Fernanda, Universidad de la República (Uruguay), Facultad de Medicina

Subjects
Injuria pulmonar, HIPERTENSION PULMONAR, Ventilacion de alta frecuencia, Ventilación no invasiva, Hipercapnia cerdo, Hipertension pulmonar del recien nacido, HIPERCAPNIA, RECIEN NACIDO
Abstract

Pilar Abella: Estudiante de Medicina, Ciclo de Metodología científica II, Facultad de Medicina, Universidad de la República, Uruguay.-- Martín Badía: Estudiante de Medicina, Ciclo de Metodología científica II, Facultad de Medicina, Universidad de la República, Uruguay.-- M. Belén Beltrán: Estudiante de Medicina, Ciclo de Metodología científica II, Facultad de Medicina, Universidad de la República, Uruguay.-- Tamara Cabral: Estudiante de Medicina, Ciclo de Metodología científica II, Facultad de Medicina, Universidad de la República, Uruguay.-- Lucía Farías: Estudiante de Medicina, Ciclo de Metodología científica II, Facultad de Medicina, Universidad de la República, Uruguay.-- M. Agustina Rico: Estudiante de Medicina, Ciclo de Metodología científica II, Facultad de Medicina, Universidad de la República, Uruguay.-- Cecilia Fernández: Departamento de Neonatología, Área Básica del Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Uruguay. -- Lucía Vaamonde: Departamento de Neonatología, Área Básica del Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Uruguay.-- Fernanda Blasina: Departamento de Neonatología, Área Básica del Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Uruguay.-- Contacto: Dra. Fernanda Blasina. Email: fblasina@gmail.com Las estrategias ventilatorias durante patologías de la transición como la hipertensión pulmonar aún requieren mejorar los resultados para disminuir morbimortalidad neonatal. El objetivo de este estudio fue comparar la efectividad de terapias ventilatorias (invasivas/no invasivas) en el tratamiento de esta patología en el recién nacido, utilizando como modelo animal cerdos recién nacidos. Los animales fueron anestesiados, ventilados y quirúrgicamente preparados para inducir daño pulmonar combinando aspiración de meconio y ácido oleico sistémico y, posteriormente, fueron asignados a uno de los siguientes grupos: control, asistencia ventilatoria mecánica, ventilación de alta frecuencia (VAF), VAF-presión continua de la vía aérea por vía nasal. Cada técnica se aplicó durante 2 horas y 30 minutos comparando parámetros ventilo-respiratorios, hemodinámicos y metabólicos. El modelo indujo hipertensión pulmonar (HTP) e hipercapnia con una situación hemodinámica sistémica estable. Cualquiera de las estrategias ventilatorias presentó similar efectividad evidenciada por su disminución significativa en presión de dióxido de carbono y valores finales de presión pulmonar sistólica similares al estado basal. Se concluyó que todas las estrategias ventilatorias son eficaces en el tratamiento de daño pulmonar en cerdos recién nacidos, sin embargo, la no invasiva resulta muy atractiva ya que presenta una potencial ventaja en inducir menor injuria pulmonar iatrogénica. La mayor velocidad en actuar de la asistencia ventilatoria mecánica puede ser ventajosa ante la gravedad, aunque el riesgo de mayor daño pulmonar inducido podría asociarse a esta modalidad. Ventilatory strategies for the treatment of neonatal transitional pathologies such as pulmonary hypertension need to be deeply explored in order to improve results to decrease newborn mortality and morbidity. The objective of this study was to compare the effectiveness of ventilatory therapies (invasive/ non-invasive) in the treatment of this pathology in the newborn, using an animal model (newborn piglets). The animals were anesthetized, ventilated and surgically prepared to induce lung injury combining meconium aspiration and systemic oleic acid. They were assigned in 4 groups: control, mechanical ventilatory assistance, high frequency ventilation (HFV), HFV with nasal continuous positive airway pressure. Each method was applied during 2 hours and 30 minutes comparing respiratory, ventilatory, hemodynamic and metabolic parameters. The lung injury model induced pulmonary hypertension and hipercapnia with a stable hemodynamic situation. All ventilatory strategies demonstrated a similar efficiency by a significant decrease in pCO2 and similar basal systolic pulmonary pressure at the end of the treatment. All the ventilatory strategies were effective in the treatment of the main parameters affected after lung injury in newborn piglets. The non-invasive strategy is more attractive, it has the potential advantage of inducing less iatrogenic lung injury. In severely affected patients the higher speed action of mechanical ventilatory assistance may be advantageous, even though this method could induce more iatrogenic injury.

Published
2019

160. Abstract 2745: Drug repositioning for triple negative breast and colorectal cancers treatment: Exploring the use of metformin and propranolol

Author

Baglioni, M Virginia, primary, Anselmino, Luciano E., additional, Laluce, Nahuel Cesatti, additional, Malizia, Florencia, additional, Chapo, Gustavo F., additional, Mainetti, Leandro E., additional, Rozados, Viviana R., additional, Scharovsky, O Graciela, additional, Rico, M. José, additional, and Márquez, Mauricio A. Menacho, additional

Published
2020
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162. LncRNA-H19 as a marker of liver progression from steatosis to hepatocellular carcinoma

Author

Rojas, Ángela, primary, Gil-Gomez, Antonio, additional, de la Cruz-Ojeda, Patricia, additional, Hernandez, Rocio Munoz, additional, Sánchez, Yolanda, additional, Gallego-Durán, Rocío, additional, Rico, M. Carmen, additional, Ferrer Rios, Maria Teresa, additional, Millan, Raquel, additional, Montero-Vallejo, Rocío, additional, Zambrano, Sheila Gato, additional, Maya, Douglas, additional, Padillo, Francisco Javier, additional, Muntané, Jordi, additional, Ampuero, Javier, additional, and Gomez, Manuel Romero, additional

Published
2020
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164. Folding kinetics of phage 434 Cro protein

Author

Laurents, D.V., Corrales, S., Elias-Arnanz, M., Sevilla, P., Rico, M., and Padmanabhan, S.

Subjects
Protein folding -- Analysis, Bacteriophage lambda -- Physiological aspects, Conformational analysis -- Research, Structure-activity relationships (Biochemistry) -- Analysis, Biological sciences, Chemistry
Abstract

Results demonstrate that phage 434 Cro protein shares similar structural and folding characteristics to the lambda repressor protein, lambda6-85. Data indicate a strongly urea-dependent refolding rates and to a lesser extent the unfolding rates with acidic pH favoring the latter.

Published
2000

165. Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study

Author

Brinkman, D, Tichelaar, J, Mokkink, L, Christiaens, T, Likic, R, Maciulaitis, R, Costa, J, Sanz, E, Maxwell, S, Richir, M, Van, A, Michiel A., L, Kostadinova, I, Ganeva, M, Atanasova, I, Gatchev, E, Stavreva, G, Vitezic, D, Matanovic, S, Wozniak, G, Nicolaou, P, Urbanek, K, Slanar, O, Kmonickova, E, Demlova, R, Bergmann, T, Damkier, P, Kalda, A, Huupponen, R, Backman, J, Drici, M, Deplanque, D, Molimard, M, Toussirot, E, Pers, Y, Bertin, P, Laviolle, B, Jeunne, C, Saulnier, P, Chamontin, B, Roustit, M, Orlikowski, D, Simon, N, Dequin, P, Angoulvant, T, Bolbrinker, J, Wojnowski, L, Cascorbi, I, Müller, F, Müller, S, Schwaninger, M, Neumann, J, Stümpel, F, Regenthal, R, Fuhr, U, Thürmann, P, Eirini, A, Papaioannidou, P, Kouvelas, D, Kolios, G, Riba, P, Kerins, D, Williams, D, Harnett, A, Spina, E, Fumagalli, G, Filippelli, A, Benemei, S, De Ponti, F, Cosentino, M, Locatelli, V, De Montis, M, Memo, M, Raschi, E, Purvina, S, Gulbinovic, J, Mifsud, J, Keijsers, K, Rissmann, R, Dumont, G, van Rosse, F, Spigset, O, Opdal, M, Braszko, J, Mirowska-Guzel, D, Broncel, M, Kocic, I, Sousa, M, Monteiro, E, Dima, L, Magyar, I, Conea, S, Buzoianu, A, Glasova, H, Tisonova, J, Glasa, J, Krzan, M, Saez-Penataro, J, de Abajo Iglesias, F, Capella, D, Figuerola, F, Sansuan, A, Lopez-Rico, M, Manso, G, Benitez, J, Lucena, M, Bernal, M, Cladellas, X, Hernandez, R, Pontes, C, Panagiotidis, G, Böttiger, Y, Wallerstedt, S, Eriksson, A, Desmeules, J, Krähenbühl, S, Plumb, R, Okorie, M, Wilson, K, Mckay, G, Sofat, R, Kapil, V, Whitfield, J, Thanacoody, R, Mir, F, Loke, Y, Schachter, M, O'Brien, L, Heep, A, Brinkman, David J, Tichelaar, Jelle, Mokkink, Lidwine B, Christiaens, Thierry, Likic, Robert, Maciulaitis, Romaldas, Costa, Joao, Sanz, Emilio J, Maxwell, Simon R, Richir, Milan C, van Agtmael, Michiel A. Lefebvre R, Kostadinova I, Ganeva M, Atanasova I, Gatchev E, Stavreva G, Vitezic D, Matanovic S, Wozniak G, Nicolaou P, Urbanek K, Slanar O, Kmonickova E, Demlova R, Bergmann T, Damkier P, Kalda A, Huupponen R, Backman J, Drici MD, Deplanque D, Molimard M, Toussirot E, Pers YM, Bertin P, Laviolle B, Jeunne CL, Saulnier PJ, Chamontin B, Roustit M, Orlikowski D, Simon N, Dequin PF, Angoulvant T, Bolbrinker J, Wojnowski L, Cascorbi I, Müller F, Müller S, Schwaninger M, Neumann J, Stümpel F, Regenthal R, Fuhr U, Thürmann P, Eirini A, Papaioannidou P, Kouvelas D, Kolios G, Riba P, Kerins D, Williams D, Harnett A, Spina E, Fumagalli G, Filippelli A, Benemei S, De Ponti F, Cosentino M, Locatelli V, De Montis MG, Memo M, Raschi E, Purvina S, Gulbinovic J, Mifsud J, Keijsers K, Rissmann R, Dumont G, van Rosse F, Spigset O, Opdal MS, Braszko J, Mirowska-Guzel D, Broncel M, Kocic I, Sousa MC, Monteiro E, Dima L, Magyar I, Conea S, Buzoianu A, Glasova H, Tisonova J, Glasa J, Krzan M, Saez-Penataro J, de Abajo Iglesias FJ, Capella D, Figuerola FAH, Sansuan AJC, Lopez-Rico M, Manso G, Benitez J, Lucena MI, Bernal ML, Cladellas XC, Hernandez RA, Pontes C, Panagiotidis G, Böttiger Y, Wallerstedt S, Eriksson A, Desmeules J, Krähenbühl S, Plumb R, Okorie M, Wilson K, McKay G, Sofat R, Kapil V, Whitfield J, Thanacoody R, Mir F, Loke Y, Schachter M, O'Brien L, Heep A, Brinkman, D, Tichelaar, J, Mokkink, L, Christiaens, T, Likic, R, Maciulaitis, R, Costa, J, Sanz, E, Maxwell, S, Richir, M, Van, A, Michiel A., L, Kostadinova, I, Ganeva, M, Atanasova, I, Gatchev, E, Stavreva, G, Vitezic, D, Matanovic, S, Wozniak, G, Nicolaou, P, Urbanek, K, Slanar, O, Kmonickova, E, Demlova, R, Bergmann, T, Damkier, P, Kalda, A, Huupponen, R, Backman, J, Drici, M, Deplanque, D, Molimard, M, Toussirot, E, Pers, Y, Bertin, P, Laviolle, B, Jeunne, C, Saulnier, P, Chamontin, B, Roustit, M, Orlikowski, D, Simon, N, Dequin, P, Angoulvant, T, Bolbrinker, J, Wojnowski, L, Cascorbi, I, Müller, F, Müller, S, Schwaninger, M, Neumann, J, Stümpel, F, Regenthal, R, Fuhr, U, Thürmann, P, Eirini, A, Papaioannidou, P, Kouvelas, D, Kolios, G, Riba, P, Kerins, D, Williams, D, Harnett, A, Spina, E, Fumagalli, G, Filippelli, A, Benemei, S, De Ponti, F, Cosentino, M, Locatelli, V, De Montis, M, Memo, M, Raschi, E, Purvina, S, Gulbinovic, J, Mifsud, J, Keijsers, K, Rissmann, R, Dumont, G, van Rosse, F, Spigset, O, Opdal, M, Braszko, J, Mirowska-Guzel, D, Broncel, M, Kocic, I, Sousa, M, Monteiro, E, Dima, L, Magyar, I, Conea, S, Buzoianu, A, Glasova, H, Tisonova, J, Glasa, J, Krzan, M, Saez-Penataro, J, de Abajo Iglesias, F, Capella, D, Figuerola, F, Sansuan, A, Lopez-Rico, M, Manso, G, Benitez, J, Lucena, M, Bernal, M, Cladellas, X, Hernandez, R, Pontes, C, Panagiotidis, G, Böttiger, Y, Wallerstedt, S, Eriksson, A, Desmeules, J, Krähenbühl, S, Plumb, R, Okorie, M, Wilson, K, Mckay, G, Sofat, R, Kapil, V, Whitfield, J, Thanacoody, R, Mir, F, Loke, Y, Schachter, M, O'Brien, L, Heep, A, Brinkman, David J, Tichelaar, Jelle, Mokkink, Lidwine B, Christiaens, Thierry, Likic, Robert, Maciulaitis, Romaldas, Costa, Joao, Sanz, Emilio J, Maxwell, Simon R, Richir, Milan C, van Agtmael, Michiel A. Lefebvre R, Kostadinova I, Ganeva M, Atanasova I, Gatchev E, Stavreva G, Vitezic D, Matanovic S, Wozniak G, Nicolaou P, Urbanek K, Slanar O, Kmonickova E, Demlova R, Bergmann T, Damkier P, Kalda A, Huupponen R, Backman J, Drici MD, Deplanque D, Molimard M, Toussirot E, Pers YM, Bertin P, Laviolle B, Jeunne CL, Saulnier PJ, Chamontin B, Roustit M, Orlikowski D, Simon N, Dequin PF, Angoulvant T, Bolbrinker J, Wojnowski L, Cascorbi I, Müller F, Müller S, Schwaninger M, Neumann J, Stümpel F, Regenthal R, Fuhr U, Thürmann P, Eirini A, Papaioannidou P, Kouvelas D, Kolios G, Riba P, Kerins D, Williams D, Harnett A, Spina E, Fumagalli G, Filippelli A, Benemei S, De Ponti F, Cosentino M, Locatelli V, De Montis MG, Memo M, Raschi E, Purvina S, Gulbinovic J, Mifsud J, Keijsers K, Rissmann R, Dumont G, van Rosse F, Spigset O, Opdal MS, Braszko J, Mirowska-Guzel D, Broncel M, Kocic I, Sousa MC, Monteiro E, Dima L, Magyar I, Conea S, Buzoianu A, Glasova H, Tisonova J, Glasa J, Krzan M, Saez-Penataro J, de Abajo Iglesias FJ, Capella D, Figuerola FAH, Sansuan AJC, Lopez-Rico M, Manso G, Benitez J, Lucena MI, Bernal ML, Cladellas XC, Hernandez RA, Pontes C, Panagiotidis G, Böttiger Y, Wallerstedt S, Eriksson A, Desmeules J, Krähenbühl S, Plumb R, Okorie M, Wilson K, McKay G, Sofat R, Kapil V, Whitfield J, Thanacoody R, Mir F, Loke Y, Schachter M, O'Brien L, and Heep A

Abstract

Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of a uniform high standard. As there are currently no uniform requirements, our aim was to achieve consensus on key learning outcomes for undergraduate CPT education in Europe. We used a modified Delphi method consisting of three questionnaire rounds and a panel meeting. A total of 129 experts from 27 European countries were asked to rate 307 learning outcomes. In all, 92 experts (71%) completed all three questionnaire rounds, and 33 experts (26%) attended the meeting. 232 learning outcomes from the original list, 15 newly suggested and 5 rephrased outcomes were included. These 252 learning outcomes should be included in undergraduate CPT curricula to ensure that European graduates are able to prescribe safely and effectively. We provide a blueprint of a European core curriculum describing when and how the learning outcomes might be acquired.

Published
2018

167. Índice de autores

Author

Montero Pérez, F. Javier, Jiménez Murillo, Luis, Agustín Romero, I., Agustín Varas, A., Alamillos Granados, F.J., Alcalá Partera, J.A., Alcolea Santiago, J., Aldeanueva Escribano, M., Álvarez Rivas, M.A., Anglada Curado, F.J., Anguita Sánchez, M., Antón Aguilar, L., Aparicio Pérez, C., Aranda Mora, A., Arévalo Frutos, P.J., Arjona Berral, J.E., Baena Delgado, E., Bajo Fernández, I., Baleato Gómez, B., Barbudo Merino, J., Barcones Gómez, C., Barneto Aranda, I., Benítez Cantero, J.M., Benítez Laguna, A.M., Berdud Godoy, I., Berenguer López, M.M., Berlango Jiménez, A., Blancas Sánchez, I., Bravo Aguilera, C., Bravo Rodríguez, F., Bretones Baena, S., Briceño Delgado, J., Cáceres Redondo, M.T., Calañas Continente, A., Calderón Caro, M., Calderón de la Barca Gázquez, J.M., Calvo Rodríguez, R., Campos Hernández, P., Cancelliere Fernández, N., Cano Castiñeira, R., Caracuel Ruiz, M.A., Castañeda Mendieta, R., Castilla Camacho, S., Cerezo Madueño, F., Clemente Millán, M.J., Cobos Ceballos, M.J., Cobos Requena, A.M., Comino Monroy, M.J., Concha Jarava, J.M., Conesa Pedrosa, I., Constenla Ramos, S., Cortázar Rocandio, G., Cruz Alcaide, A.B., de Burgos Marín, J., de Dios Ruiz, A.M., de la Mata García, M., de la Torre Castillo, O.M., de la Torre Cisneros, J., de la Torre González, A., de Prado López, M.F., Deán Ferrer, A., Degayón Rojo, H., Delgado Acosta, F., Díaz Rueda, L., Domínguez Grande, M.L., Dueñas Jurado, J.M., Durán Serantes, M., Duro Gómez, J., Entrenas Castillo, M., Entrenas Costa, L.M., Escuder Egea, R., Espejo Pérez, S., Espejo Rodríguez, E., Esquivias de Motta, E., Expósito Ordóñez, A., Fernández Camacho, I., Fernández de la Puebla Lechuga, E., Fernández Martínez, N.F., Fernández Sánchez de Mora, M.C., Fernández Valverde, F., Franco Jiménez, A., Gallardo Valverde, J.M., Gálvez Moreno, M.A., García Díaz, L., García Lázaro, M., García Martínez, E., García Quintana, J.M., García Rubio, J.H., García Sánchez, V., García Vázquez, A.M., García-Arévalo Arellano, R., Gavilán Guirao, F., Gil Hernández, S., Giménez Ruiz, J.J., Gimeno Gimeno, M.J., Gómez Gómez, E., Gómez Panzuela, N., González Campillo, M.T., González de Caldas Marchal, R., González Galilea, A., González García, F.M., González Requero, A.I., González Romero, M.D., González Teomiro, C., Gracia García, F., Guerra Vilches, V., Guerrero-León, M.A., Herrero González, Y., Hinojosa Marín, B., Iglesias Flores, E., Jiménez Aguilar, A.M., Jiménez Gallardo, J., Jiménez Murillo, L., Jiménez Puya, M.C., Jiménez Villalta, M.T., Jurado Gámez, B., Jurado García, J., Ladehesa Pineda, L., Lama Martínez, R., Larrasa Soriano, S., Leal Reyes, G., León López, R., Llamas Fuentes, R., Llamas Quiñones, L., Llergo Muñoz, A., López Granados, A., López Hurtado, F., López Malo de Molina, D., López Miranda, J., López Ruiz, D., Lorente González, J., Lorenzo Montero, M.J., Lozano Jiménez, M.J., Lucchini Leiva, R., Lucena Aguilera, C., Luna Morales, S., Machuca Sánchez, I.M., Marín Martín, E., Marín Pedrosa, S., Martín de León, R., Martín Malo, A., Martín Sosa, M.M., Martínez Acevedo, E., Martínez García, A.I., Martínez Grueiro, M., Martínez Losada, C., Martínez Mesones, L., Martínez Virto, A.M., Martos Órpez, M.C., Mateo Mateo, F., Medinilla Montenegro, M.C., Mellado Castillero, A., Menchero Sánchez-Migallón, C., Mesa Rubio, M.D., Mifsut Gallardo, M.J., Molina Nieto, T., Monserrat Barbudo, O., Monserrat Jordán, J.A., Montero Pérez, F.J., Mora Sánchez, A., Moreno Herrera, C.M., Moreno Montero, I., Moreno Navas, A., Moreno Sorribas, S., Moreno Velasco, I., Moya González, J., Moyano Pulido, M.J., Muñoz Carvajal, I., Muñoz del Castillo, F., Muñoz Triano, E., Natera Kindelán, C., Nieto Pascual, L., Nogué Bou, R., Pacheco Capote, C., Padilla Rico, M., Padillo Cuenca, J.C., Palacios Eito, A., Palenzuela Martín, S., Palomar Alguacil, V., Palomar Muñoz, M.C., Palomares Ortega, R., Pan Álvarez-Osorio, M., Pascual Martínez, N., Peláez Viña, N., Pérez Montilla, M.E., Pérez Rodríguez, E., Postigo Arrabal, S., Pugnet, G., Quero Espinosa, F.B., Quintana Díaz, M., Ramos Gómez, M., Recio Bermejo, M., Redel Montero, J., Reyes Vallejo, R., Ríos Jiménez, D., Rivero Román, A., Robles Arista, J.C., Rodríguez Alonso, B., Rodríguez Alonso, R., Rodríguez Benot, A., Rodríguez Cano, M.E., Rodríguez Cantalejo, F., Rodríguez Fuertes, P., Rodríguez Marín, A.B., Rodríguez Perálvarez, M., Rodríguez Salas, M., Roig Rodríguez, J.J., Roka Nchaso, L.A., Roldán Romero, E., Romero Bravo, A., Romero Moreno, M.A., Rueda García, R.L., Ruiz García, J., Ruiz Ortiz, M., Ruiz Ruiz, E., Ruiz Sáez, B., Rumbao Aguirre, J.M., Sainz de la Cuesta Alonso, S., Salamanca Bustos, J.J., Salas Hernández, F., Salcedo Leal, I., Salvatierra Velázquez, A., Sánchez Alcántara, M.B., Sánchez del Solar, M.L., Santos Luna, F., Seguí Azpilcueta, P., Segura Saint-Gerons, J., Serrano Blanch, R., Serrano Moreno, E., Serrano Ortiz, A., Solivera Vera, J., Tirado Valencia, C., Toledano Delgado, A., Torres Degayón, E., Torres Degayón, S., Torres Degayón, V., Torres Murillo, J.M., Triviño Tarradas, F., Valero Rosa, J., Vallejo Casas, J.A., Valverde Moyano, R., Vaquero Barrios, J.M., Vega Reyes, J.A., Velázquez Navarrete, M.C., Vélez García-Nieto, A.J., Vicente Rueda, J., Vicho González, C., Vida Pérez, L., Vida Pérez, M., Vidal Verdú, E., Vignote Alguacil, M.L., Villalba Calvente, M., Villalba Montoro, R., Villar García, J., Yagüe Martín, M., and Yébenes Ramírez, M.

Published
2023
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168. Thermodynamic analysis of the structural stability of phage 434 Cro protein

Author

Padmanabhan, S., Laurents, D.V., Fernandez, A.M., Elias-Arnaz, M., Ruiz-Sanz, J., Mateo, P.L., Rico, M., and Filimonov, V.V.

Subjects
Thermodynamics -- Research, Proteins -- Conformation, Protein folding -- Research, Structural stability -- Analysis, Biological sciences, Chemistry
Abstract

Results on folding and conformational stability of phage 434 Cro protein as influenced by thermodynamic properties temperature, pH, change in heat capacity, free energy, etc. are presented.

Published
1999

182. Posters

Author

Frutos, F., Nuñez, C., Garrido, P., Lorenzo, J. M., Aranda, M., Revuelta, P., Chinea, C., Rico, M., Ibáñez-Nolla, J., León-Regidor, M. A., Díaz-Boladeras, R. M., García-Hernández, F., Nolla-Salas, M., Sirvent, J. M., Torres, A., El-Ebiary, M., Castro, P., de Batlle, J., de Velasco, J. G., Alvarez, A., Bonet, A., Thomas, M. L., McLure, H. A., Soni, N., Roberts, A. P., Azadian, B. F., Tibby, S. M., Cheema, I. U., Cox, S., Gransden, W. R., Murdoch, I. A., Tayoro, J., Legras, A., Dequin, P. F., Hazouard, E., Perrotin, D., Anglès, R., de Latorre, F. J., Ferrer, A., Palomar, M., Burgueńo, M. J., Bosque, M. D., Pont, T., Bermejo, B., Melgar, J. L., Chamorro, C., Romera, M. A., Borrallo, J. M., de Luna, R. Ruiz, De la Calle, N., Sousa-Dias, C., Paiva, J. A., Pereira, A. Costa, Ribeiro, T., Gomes, J., Carmo, E., Gaspar, I., Simões, I., Monteiro, E., Neves, J. L., Abecasis, P., Álvarez-Lerma, F., de la Cal, M. A., Insausti J., Olaechea, P., Anđelić, N., Ćosić, O., Risović, M., Todorović, K., Đukić, V., Karamarković, A., Ricart, A., Garrigosa, F., Prieto, A. Diaz, Casanovas, T., Rodriguez, P., Avila, F. J., Pujol, M., Ariza, X., Shunko, E., Polishchuk, O., Kostiuk, O., Poluliakh, O., Nys, M., Damas, P., Ledoux, D., De Mol, P., Melin, P., Lamy, M., Ivanović, D., Radonić, R., Gaŝparović, V., Merkler, M., Gjuraŝin, M., van ’t Veen, A., Gommers, D., Mouton, J. W., Kluytmans, J. A. J. W., Lachmann, B., Adnet, F., Bekka, R., Vicaut, E., Lapostolle, F., Giraudeaux, V., Bismuth, C., Baud, F., Young, S. P., Haj, M. A., Robbie, L. A., Adey, G., Croll, A. M., Booth, N. A., Bennett, B., Santos, J. A., Ormaechea, E., Barcons, M., Quintana, E., Rialp, G., Bak, E., Puzo, C., Coll, P., Net, A., Blazková, M., Ŝteparová, P., Nejdlová, H., Jelínková, L., Winkelhoferová, H., Rokyta, R., Matejovic, M., Ŝrámck, V., Novák, I., Blinzler, L., Franz-Kilian, K., Benda, N., Heuser, D., Lerma, F. Alvarez, Maladorno, D., Hager, H., Richelo, B., Teller, S., Berkowicz, C., O’Brien, D., Leighton, A., Dougnac, A., Hernandez, G., Angus, D., Ojeda, M., Castro, J., Labarca, E., Castillo, L., Andresen, M., Bugedo, G., Diaz, O., Arriagada, D., Dagnino, J., Spanish Study Group of Surveillance of ICU-Acquired Infection, Spanish Study Group of Surveillance of ICU-acquired Infection., and Ro 4S-2081 Study Group

Published
1996
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184. Using coupling with the Gibbs sampler to assess convergence in animal models

Author

Garcia-Cortes, L.A., Rico, M., and Groeneveld, E.

Subjects
Gibbs' equation -- Usage, Animal models in research -- Analysis, Markov processes -- Usage, Bayesian statistical decision theory -- Usage, Zoology and wildlife conservation
Abstract

The coupling method was investigated as a method to assess the convergence of the Gibbs sampler when drawing marginal inferences with an animal model. This method is based on the output of two Markov chains with different starting values but the same conditional deviates. The coupling method shows that the Gibbs sampler has an exponential convergence when the variance components are assumed to be known. All the variables in the model have the same rate of convergence, and it is closely related with the largest eigenvalue of a matrix derived from the coefficient matrix of the mixed model equations. Models including the variance components as unknowns showed a rate of convergence equal for all the variables, and this rate of convergence was approximately exponential. The coupling method provides an estimation of the convergence at the current iteration, and it does not require a post-Gibbs analysis as do the single chain-based methods. The coupling method is less computationally demanding than multiple chain methods, because only two chains are required to assess convergence. Key Words: Markov Processes, Genetics, Variance Components, Computer Software, Bayesian Theory

Published
1998

189. Three-dimensional solution structure and stability of phage 434 Cro protein

Author

Padmanabhan, S., Jimenez, M.A., Gonzalez, C., Sanz, J.M., Gimenez-Gallego, G., and Rico, M.

Subjects
Bacteriophages -- Research, DNA binding proteins -- Research, Biological sciences, Chemistry
Abstract

NMR resonance assignments and crystal structures of phage 434 Cro protein were analyzed to determine the stability and DNA-binding characteristics of the bacteriophage under different solutions. Results show that the phage 434 Cro protein and several other DNA-binding gene-regulatory proteins have structural similarities. Results also reveal that 434 Cro is monomeric even at high NMR concentrations and that folding under NMR solution condition is a two-state process.

Published
1997

190. A stochastic agent-based model of the SARS-CoV-2 epidemic in France

Author

Hoertel, N., Blachier, M., Blanco, C., Olfson, M., Massetti, Massimo, Rico, M. S., Limosin, F., Leleu, H., Massetti M. (ORCID:0000-0002-7100-8478), Hoertel, N., Blachier, M., Blanco, C., Olfson, M., Massetti, Massimo, Rico, M. S., Limosin, F., Leleu, H., and Massetti M. (ORCID:0000-0002-7100-8478)

Abstract

Many European countries have responded to the COVID-19 pandemic by implementing nationwide protection measures and lockdowns1. However, the epidemic could rebound when such measures are relaxed, possibly leading to a requirement for a second or more, repeated lockdowns2. Here, we present results of a stochastic agent-based microsimulation model of the COVID-19 epidemic in France. We examined the potential impact of post-lockdown measures, including physical distancing, mask-wearing and shielding individuals who are the most vulnerable to severe COVID-19 infection, on cumulative disease incidence and mortality, and on intensive care unit (ICU)-bed occupancy. While lockdown is effective in containing the viral spread, once lifted, regardless of duration, it would be unlikely to prevent a rebound. Both physical distancing and mask-wearing, although effective in slowing the epidemic and in reducing mortality, would also be ineffective in ultimately preventing ICUs from becoming overwhelmed and a subsequent second lockdown. However, these measures coupled with the shielding of vulnerable people would be associated with better outcomes, including lower mortality and maintaining an adequate ICU capacity to prevent a second lockdown. Benefits would nonetheless be markedly reduced if most people do not adhere to these measures, or if they are not maintained for a sufficiently long period.

Published
2020

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