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154. Is Age Kinder to the Initially More Able?: Yes, and No

Author

Gow, Alan J., Johnson, Wendy, Mishra, Gita, Richards, Marcus, Kuh, Diana, and Deary, Ian J.

Abstract

Although a number of analyses have addressed whether initial cognitive ability level is associated with age-related cognitive decline, results have been inconsistent. Latent growth curve modeling was applied to two aging cohorts, extending previous analyses with a further wave of data collection, or as a more appropriate analytical methodology than used previously. In the Lothian Birth Cohort 1921, cognitive ability at age 11 was not associated with cognitive change from age 79 to 87, either in general cognitive ability, or in tests of reasoning, memory and executive function. However, data from the MRC National Survey of Health and Development suggested that higher cognitive ability at age 15 predicted less decline between ages 43 and 53 years in a latent cognitive factor from tests of verbal memory and search speed, and in search speed when considered separately. The results are discussed in terms of the differences between the cohorts and the interpretability of the analytical approach. Suggestions are made about when initial ability might be cognitively protective, and study requirements to bring about a clearer resolution. (Contains 2 figures and 7 tables.)

Published
2012
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157. Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort

Author

Keuss, Sarah E., primary, Coath, William, additional, Nicholas, Jennifer M., additional, Poole, Teresa, additional, Barnes, Josephine, additional, Cash, David M., additional, Lane, Christopher A., additional, Parker, Thomas D., additional, Keshavan, Ashvini, additional, Buchanan, Sarah M., additional, Wagen, Aaron Z., additional, Storey, Mathew, additional, Harris, Matthew, additional, Malone, Ian B., additional, Sudre, Carole H., additional, Lu, Kirsty, additional, James, Sarah-Naomi, additional, Street, Rebecca, additional, Thomas, David L., additional, Dickson, John C., additional, Murray-Smith, Heidi, additional, Wong, Andrew, additional, Freiberger, Tamar, additional, Crutch, Sebastian, additional, Richards, Marcus, additional, Fox, Nick C., additional, and Schott, Jonathan M., additional

Published
2022
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158. CONCEPTUAL ADVANCEMENT: SOCIAL HEALTH AS A FACILITATOR IN THE USE OF COGNITIVE RESERVE

Author

Vernooij-Dassen, Myrra, primary, Verspoor, Eline, additional, Samtani, Suraj, additional, Sachdev, Perminder, additional, Ikram, M. Arfan, additional, Vernooij, Meike W., additional, Hubers, Claudia, additional, Chattat, Rabih, additional, Lenart, Marta, additional, Rymaszewska, Joanna, additional, Szczesnia, Dorota, additional, Brodaty, Henry, additional, Welmer, Anna-Karin, additional, Maddock, Jane, additional, van der Velpen, Isabelle, additional, Wiegelmann, Henrik, additional, Marseglia, Anna, additional, Richards, Marcus, additional, Melis, Rene, additional, de Vugt, Marjolein, additional, Moniz-Cook, Esme, additional, Jeon, Yun-Hee, additional, Perry, Marieke, additional, and Wolf-Ostermann, Karin, additional

Published
2022
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160. IQ in Childhood and the Metabolic Syndrome in Middle Age: Extended Follow-Up of the 1946 British Birth Cohort Study

Author

Richards, Marcus, Black, Stephanie, Mishra, Gita, Gale, Catharine R., Deary, Ian J., and Batty, David G.

Abstract

IQ in early adulthood has been inversely associated with risk of the metabolic syndrome in midlife. We tested this association in the British 1946 birth cohort, which assessed IQ at age eight years and ascertained the metabolic syndrome at age 53 years based on modified (non-fasting blood) ATPIII criteria. Childhood IQ was inversely associated with risk of the metabolic syndrome, but this association was almost entirely mediated by educational attainment and achieved occupational social class. This may be consistent with a pattern where childhood IQ is strongly associated with outcomes that reflect neurological disorder, such as the degenerative dementias, but less so with common chronic physical diseases of ageing. (Contains 1 table and 1 figure.)

Published
2009
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161. Population-based blood screening for preclinical Alzheimer’s disease in a British birth cohort at age 70

Author

Keshavan, Ashvini, Pannee, Josef, Karikari, Thomas K, Rodriguez, Juan Lantero, Ashton, Nicholas J, Nicholas, Jennifer M, Cash, David M, Coath, William, Lane, Christopher A, Parker, Thomas D, Lu, Kirsty, Buchanan, Sarah M, Keuss, Sarah E, James, Sarah-Naomi, Murray-Smith, Heidi, Wong, Andrew, Barnes, Anna, Dickson, John C, Heslegrave, Amanda, Portelius, Erik, Richards, Marcus, Fox, Nick C, Zetterberg, Henrik, Blennow, Kaj, and Schott, Jonathan M

Subjects
Male, Amyloid beta-Peptides, Hematologic Tests, AcademicSubjects/SCI01870, beta-amyloid, Original Articles, Sensitivity and Specificity, Peptide Fragments, Early Diagnosis, Alzheimer Disease, mental disorders, Humans, AcademicSubjects/MED00310, epidemiology, Female, tau, Prospective Studies, amyloid imaging, Alzheimer’s disease, Biomarkers, dementia, Aged
Abstract

Alzheimer’s disease has a preclinical stage when cerebral amyloid-β deposition occurs before symptoms emerge, and when amyloid-β-targeted therapies may have maximum benefits. Existing amyloid-β status measurement techniques, including amyloid PET and CSF testing, are difficult to deploy at scale, so blood biomarkers are increasingly considered for screening. We compared three different blood-based techniques—liquid chromatography-mass spectrometry measures of plasma amyloid-β, and single molecule array (Simoa) measures of plasma amyloid-β and phospho-tau181—to detect cortical 18F-florbetapir amyloid PET positivity (defined as a standardized uptake value ratio of >0.61 between a predefined cortical region of interest and eroded subcortical white matter) in dementia-free members of Insight 46, a substudy of the population-based British 1946 birth cohort. We used logistic regression models with blood biomarkers as predictors of amyloid PET status, with or without age, sex and APOE ε4 carrier status as covariates. We generated receiver operating characteristics curves and quantified areas under the curves to compare the concordance of the different blood tests with amyloid PET. We determined blood test cut-off points using Youden’s index, then estimated numbers needed to screen to obtain 100 amyloid PET-positive individuals. Of the 502 individuals assessed, 441 dementia-free individuals with complete data were included; 82 (18.6%) were amyloid PET-positive. The area under the curve for amyloid PET status using a base model comprising age, sex and APOE ε4 carrier status was 0.695 (95% confidence interval: 0.628–0.762). The two best-performing Simoa plasma biomarkers were amyloid-β42/40 (0.620; 0.548–0.691) and phospho-tau181 (0.707; 0.646–0.768), but neither outperformed the base model. Mass spectrometry plasma measures performed significantly better than any other measure (amyloid-β1-42/1-40: 0.817; 0.770–0.864 and amyloid-β composite: 0.820; 0.775–0.866). At a cut-off point of 0.095, mass spectrometry measures of amyloid-β1-42/1-40 detected amyloid PET positivity with 86.6% sensitivity and 71.9% specificity. Without screening, to obtain 100 PET-positive individuals from a population with similar amyloid PET positivity prevalence to Insight 46, 543 PET scans would need to be performed. Screening using age, sex and APOE ε4 status would require 940 individuals, of whom 266 would proceed to scan. Using mass spectrometry amyloid-β1-42/1-40 alone would reduce these numbers to 623 individuals and 243 individuals, respectively. Across a theoretical range of amyloid PET positivity prevalence of 10–50%, mass spectrometry measures of amyloid-β1-42/1-40 would consistently reduce the numbers proceeding to scans, with greater cost savings demonstrated at lower prevalence., Keshavan et al. show that plasma Aβ1-42/1-40 and a plasma Aβ composite measured by liquid chromatography–mass spectrometry perform better than various blood biomarkers measured by single molecular array, and better than age, sex and APOE ε4, in screening for preclinical Alzheimer’s disease in the British 1946 birth cohort.

Published
2021

162. Recognition of social health : A conceptual framework in the context of dementia research

Author

Vernooij-Dassen, Myrra, Verspoor, Eline, Samtani, Suraj, Sachdev, Perminder S., Ikram, M. Arfan, Vernooij, Meike W., Hubers, Claudia, Chattat, Rabih, Lenart-Bugla, Marta, Rymaszewska, Joanna, Szczesniak, Dorota, Brodaty, Henry, Welmer, Anna-Karin, Maddock, Jane, van der Velpen, Isabelle F., Wiegelmann, Henrik, Marseglia, Anna, Richards, Marcus, Melis, Rene, de Vugt, Marjolein, Moniz-Cook, Esme, Jeon, Yun-Hee, Perry, Marieke, Wolf-Ostermann, Karin, Vernooij-Dassen, Myrra, Verspoor, Eline, Samtani, Suraj, Sachdev, Perminder S., Ikram, M. Arfan, Vernooij, Meike W., Hubers, Claudia, Chattat, Rabih, Lenart-Bugla, Marta, Rymaszewska, Joanna, Szczesniak, Dorota, Brodaty, Henry, Welmer, Anna-Karin, Maddock, Jane, van der Velpen, Isabelle F., Wiegelmann, Henrik, Marseglia, Anna, Richards, Marcus, Melis, Rene, de Vugt, Marjolein, Moniz-Cook, Esme, Jeon, Yun-Hee, Perry, Marieke, and Wolf-Ostermann, Karin

Abstract

Objective: The recognition of dementia as a multifactorial disorder encourages the exploration of new pathways to understand its origins. Social health might play a role in cognitive decline and dementia, but conceptual clarity is lacking and this hinders investigation of associations and mechanisms. The objective is to develop a Conceptual framework for social health to advance conceptual clarity in future studies. Process: We use the following steps: underpinning for concept advancement, concept advancement by the development of a conceptual model, and exploration of its potential feasibility. An iterative consensus-based process was used within the international multidisciplinary SHARED project. Conceptual framework: Underpinning of the concept drew from a synthesis of theoretical, conceptual and epidemiological work, and resulted in a definition of social health as wellbeing that relies on capacities both of the individual and the social environment. Consequently, domains in the conceptual framework are on both the individual (e.g., social participation) and the social environmental levels (e.g., social network). We hypothesize that social health acts as a driver for use of cognitive reserve which can then slow cognitive impairment or maintain cognitive functioning. The feasibility of the conceptual framework is demonstrated in its practical use in identifying and structuring of social health markers within the SHARED project. Discussion: The conceptual framework provides guidance for future research and facilitates identification of modifiable risk and protective factors, which may in turn shape new avenues for preventive interventions. We highlight the paradigm of social health in dementia as a priority for dementia research.

Published
2022
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163. Recognition of social health:A conceptual framework in the context of dementia research

Author

Vernooij-Dassen, Myrra, Verspoor, Eline, Samtani, Suraj, Sachdev, Perminder S., Ikram, M. Arfan, Vernooij, Meike W., Hubers, Claudia, Chattat, Rabih, Lenart-Bugla, Marta, Rymaszewska, Joanna, Szczesniak, Dorota, Brodaty, Henry, Welmer, Anna Karin, Maddock, Jane, van der Velpen, Isabelle F., Wiegelmann, Henrik, Marseglia, Anna, Richards, Marcus, Melis, Rene, de Vugt, Marjolein, Moniz-Cook, Esme, Jeon, Yun Hee, Perry, Marieke, Wolf-Ostermann, Karin, Vernooij-Dassen, Myrra, Verspoor, Eline, Samtani, Suraj, Sachdev, Perminder S., Ikram, M. Arfan, Vernooij, Meike W., Hubers, Claudia, Chattat, Rabih, Lenart-Bugla, Marta, Rymaszewska, Joanna, Szczesniak, Dorota, Brodaty, Henry, Welmer, Anna Karin, Maddock, Jane, van der Velpen, Isabelle F., Wiegelmann, Henrik, Marseglia, Anna, Richards, Marcus, Melis, Rene, de Vugt, Marjolein, Moniz-Cook, Esme, Jeon, Yun Hee, Perry, Marieke, and Wolf-Ostermann, Karin

Abstract

Objective: The recognition of dementia as a multifactorial disorder encourages the exploration of new pathways to understand its origins. Social health might play a role in cognitive decline and dementia, but conceptual clarity is lacking and this hinders investigation of associations and mechanisms. The objective is to develop a conceptual framework for social health to advance conceptual clarity in future studies. Process: We use the following steps: underpinning for concept advancement, concept advancement by the development of a conceptual model, and exploration of its potential feasibility. An iterative consensus-based process was used within the international multidisciplinary SHARED project. Conceptual framework: Underpinning of the concept drew from a synthesis of theoretical, conceptual and epidemiological work, and resulted in a definition of social health as wellbeing that relies on capacities both of the individual and the social environment. Consequently, domains in the conceptual framework are on both the individual (e.g., social participation) and the social environmental levels (e.g., social network). We hypothesize that social health acts as a driver for use of cognitive reserve which can then slow cognitive impairment or maintain cognitive functioning. The feasibility of the conceptual framework is demonstrated in its practical use in identifying and structuring of social health markers within the SHARED project. Discussion: The conceptual framework provides guidance for future research and facilitates identification of modifiable risk and protective factors, which may in turn shape new avenues for preventive interventions. We highlight the paradigm of social health in dementia as a priority for dementia research.

Published
2022

167. Changes in the adult consequences of adolescent mental ill-health: findings from the 1958 and 1970 British birth cohorts.

Author

Thompson, Ellen J., Richards, Marcus, Ploubidis, George B., Fonagy, Peter, and Patalay, Praveetha

Subjects
*MULTIPLE regression analysis, *HEALTH status indicators, *REGRESSION analysis, *SOCIOECONOMIC factors, *RESEARCH funding, *DISEASE prevalence, *ODDS ratio, *MENTAL illness, *LONGITUDINAL method, *ADULTS, *ADOLESCENCE
Abstract

Background: Adolescent mental health difficulties are increasing over time. However, it is not known whether their adulthood health and socio-economic sequelae are changing over time. Methods: Participants (N = 31 349) are from two prospective national birth cohort studies: 1958 National Child Development Study (n = 16 091) and the 1970 British Cohort Study (n = 15 258). Adolescent mental health was operationalised both as traditional internalising and externalising factors and a hierarchical bi-factor. Associations between adolescent psychopathology and age 42 health and wellbeing (mental health, general health, life satisfaction), social (cohabitation, voting behaviour) and economic (education and employment) outcomes are estimated using linear and logistic multivariable regressions across cohorts, controlling for a wide range of early life potential confounding factors. Results: The prevalence of adolescent mental health difficulties increased and their associations with midlife health, wellbeing, social and economic outcomes became more severe or remained similar between those born in 1958 and 1970. For instance, a stronger association with adolescent mental health difficulties was found for those born in 1970 for midlife psychological distress [odds ratio (OR) 1970 = 1.82 (1.65–1.99), OR 1958 = 1.60 (1.43–1.79)], cohabitation [OR 1970 = 0.64 (0.59–0.70), OR 1958 = 0.79 (0.72–0.87)], and professional occupations [OR 1970 = 0.75 (0.67–0.84), OR 1958 = 1.05 (0.88–1.24)]. The associations of externalising symptoms with later outcomes were mainly explained by their shared variance with internalising symptoms. Conclusion: The widening of mental health-based inequalities in midlife outcomes further supports the need to recognise that secular increases in adolescent mental health symptoms is a public health challenge with measurable negative consequences through the life-course. Increased public health efforts to minimise adverse outcomes are needed. [ABSTRACT FROM AUTHOR]

Published
2023
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169. Psychological Distress Before and During the COVID-19 Pandemic Among Adults in the United Kingdom Based on Coordinated Analyses of 11 Longitudinal Studies

Author

Patel, Kishan, primary, Robertson, Elaine, additional, Kwong, Alex S. F., additional, Griffith, Gareth J., additional, Willan, Kathryn, additional, Green, Michael J., additional, Di Gessa, Giorgio, additional, Huggins, Charlotte F., additional, McElroy, Eoin, additional, Thompson, Ellen J., additional, Maddock, Jane, additional, Niedzwiedz, Claire L., additional, Henderson, Morag, additional, Richards, Marcus, additional, Steptoe, Andrew, additional, Ploubidis, George B., additional, Moltrecht, Bettina, additional, Booth, Charlotte, additional, Fitzsimons, Emla, additional, Silverwood, Richard, additional, Patalay, Praveetha, additional, Porteous, David, additional, and Katikireddi, Srinivasa Vittal, additional

Published
2022
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174. Circulating Metabolome and White Matter Hyperintensities in Females and Males

Author

SLIZ, Eeva, SHIN, Jean, AHMAD, Shahzad, WILLIAMS, Dylan M, FRENZEL, Stefan, GAUSS, Friederike, HARRIS, Sarah E., HENNING, Ann-Kristin, VALDES HERNANDEZ, Maria Del C., HU, Yi-Han, JIMENEZ, Beatriz, SARGURUPREMRAJ, Muralidharan, SUDRE, Carole, WANG, Ruiqi, WITTFELD, Katharina, YANG, Qiong, WARDLAW, Joanna M., VOLZKE, Henry, VERNOOIJ, Meike W., SCHOTT, Jonathan M., RICHARDS, Marcus, PROITSI, Petroula, NAUCK, Matthias, LEWIS, Matthew R., LAUNER, Lenore, HOSTEN, Norbert, GRABE, Hans J., GHANBARI, Mohsen, DEARY, Ian J., COX, Simon R., CHATURVEDI, Nishi, BARNES, Josephine, ROTTER, Jerome I., DEBETTE, Stephanie, IKRAM, M. Arfan, FORNAGE, Myriam, PAUS, Tomas, SESHADRI, Sudha, and PAUSOVA, Zdenka

Published
2022

175. sj-pdf-1-cpx-10.1177_21677026221095856 – Supplemental material for Psychological Distress Across Adulthood: Equating Scales in Three British Birth Cohorts

Author

Jongsma, Hannah E., Moulton, Vanessa G., Ploubidis, George B., Gilbert, Emily, Richards, Marcus, and Patalay, Praveetha

Subjects
FOS: Psychology, 170199 Psychology not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-cpx-10.1177_21677026221095856 for Psychological Distress Across Adulthood: Equating Scales in Three British Birth Cohorts by Hannah E. Jongsma, Vanessa G. Moulton, George B. Ploubidis, Emily Gilbert, Marcus Richards and Praveetha Patalay in Clinical Psychological Science

Published
2022
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179. Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease

Author

Green, Rebecca, primary, Lord, Jodie, additional, Scelsi, Marzia A, additional, Xu, Jin, additional, Wong, Andrew, additional, Naomi-James, Sarah, additional, Handy, Alex, additional, Gilchrist, Lachlan, additional, Williams, Dylan M, additional, Parker, Thomas D, additional, Lane, Christopher A, additional, Malone, Ian B, additional, Sudre, Carole H, additional, Coath, William, additional, Thomas, David L, additional, Keuss, Sarah, additional, Dobson, Richard, additional, Legido-Quigley, Cristina, additional, Fox, Nick C, additional, Schott, Jonathan M, additional, Richards, Marcus, additional, and Proitsi, Petroula, additional

Published
2022
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180. Autism in the UK: Investigating Underdiagnosis in a Population-Based Cohort

Author

O'Nions, Elizabeth, primary, Petersen, Irene, additional, Buckman, Joshua Eusty Jonathan, additional, Charlton, Rebecca, additional, Cooper, Claudia, additional, Corbett, Anne, additional, Happé, Francesca, additional, Manthorpe, Jill, additional, Richards, Marcus, additional, Saunders, Rob, additional, Zanker, Cathy, additional, Mandy, William, additional, and Stott, Joshua, additional

Published
2022
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183. Implementation of remote neuropsychological assessments in the Insight 46 study: Lessons learned from the transition to videoconferencing and telephone assessments

Author

Street, Rebecca E, primary, Lu, Kirsty, additional, Freiberger, Tamar, additional, Murray‐Smith, Heidi, additional, Keuss, Sarah E, additional, Baker, John, additional, Wong, Andrew, additional, Richards, Marcus, additional, Fox, Nick C, additional, Crutch, Sebastian J, additional, and Schott, Jonathan M, additional

Published
2021
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185. Fixel‐based analysis of the effect of amyloid beta on white matter tracts in neurologically normal 70 year olds

Author

Wagen, Aaron Z., primary, Zarkali, Angeliki, additional, Coath, William, additional, Buchanan, Sarah M., additional, Keuss, Sarah E., additional, Keshavan, Ashvini, additional, Lu, Kirsty, additional, James, Sarah‐Naomi, additional, Pavisic, Ivanna M., additional, Street, Rebecca E., additional, Parker, Thomas D., additional, Lane, Christopher A., additional, Murray‐Smith, Heidi, additional, Cash, David M., additional, Malone, Ian B., additional, Wong, Andrew, additional, Richards, Marcus, additional, Fox, Nick C., additional, Altmann, Andre, additional, Cole, James H., additional, Weil, Rimona S., additional, and Schott, Jonathan M., additional

Published
2021
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186. Cognitive impairment and World Trade Centre-related exposures

Author

Clouston, Sean A. P., primary, Hall, Charles B., additional, Kritikos, Minos, additional, Bennett, David A., additional, DeKosky, Steven, additional, Edwards, Jerri, additional, Finch, Caleb, additional, Kreisl, William C., additional, Mielke, Michelle, additional, Peskind, Elaine R., additional, Raskind, Murray, additional, Richards, Marcus, additional, Sloan, Richard P., additional, Spiro, Avron, additional, Vasdev, Neil, additional, Brackbill, Robert, additional, Farfel, Mark, additional, Horton, Megan, additional, Lowe, Sandra, additional, Lucchini, Roberto G., additional, Prezant, David, additional, Reibman, Joan, additional, Rosen, Rebecca, additional, Seil, Kacie, additional, Zeig-Owens, Rachel, additional, Deri, Yael, additional, Diminich, Erica D., additional, Fausto, Bernadette A., additional, Gandy, Sam, additional, Sano, Mary, additional, Bromet, Evelyn J., additional, and Luft, Benjamin J., additional

Published
2021
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187. The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here?

Author

Peters, Ruth, primary, Dodge, Hiroko H., additional, James, Sarah, additional, Jicha, Gregory A., additional, Meyer, Pierre‐Francois, additional, Richards, Marcus, additional, Smith, A. David, additional, Yassine, Hussein N., additional, Abner, Erin, additional, Hainsworth, Atticus H., additional, Kehoe, Patrick G., additional, Beckett, Nigel, additional, Anderson, Craig S., additional, and Anstey, Kaarin J., additional

Published
2021
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192. Psychological Distress Before and During the COVID-19 Pandemic Among Adults in the United Kingdom: Coordinated Analyses of 11 Longitudinal Studies

Author

Patel, Kishan, primary, Robertson, Elaine, additional, Kwong, Alex S. F., additional, Griffith, Gareth J, additional, Willan, Kathryn, additional, Green, Michael J, additional, Di Gessa, Giorgio, additional, Huggins, Charlotte F., additional, McElroy, Eoin, additional, Thompson, Ellen J., additional, Maddock, Jane, additional, Niedzwiedz, Claire L, additional, Henderson, Morag, additional, Richards, Marcus, additional, Steptoe, Andrew, additional, Ploubidis, George B., additional, Moltrecht, Bettina, additional, Booth, Charlotte, additional, Fitzsimons, Emla, additional, Silverwood, Richard, additional, Patalay, Praveetha, additional, Porteous, David, additional, and Katikireddi, Srinivasa Vittal, additional

Published
2021
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195. P28 Social relationships and cognitive decline in adulthood: an investigation from the MRC national survey of health and development and the English longitudinal study of ageing

Author

Maddock, Jane, primary, Marseglia, Anna, additional, Gallo, Federico, additional, Dekhtyar, Serhiy, additional, Welmer, Anna-Karin, additional, Wolters, Frank J, additional, Ikram, Mohammad Arfan, additional, Davis, Daniel, additional, Ploubidis, George B, additional, and Richards, Marcus, additional

Published
2021
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199. Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes

Author

Talmud, Philippa J., Cooper, Jackie A., Morris, Richard W., Dudbridge, Frank, Shah, Tina, Engmann, Jorgen, Dale, Caroline, White, Jon, McLachlan, Stela, Zabaneh, Delilah, Wong, Andrew, Ong, Ken K., Gaunt, Tom, Holmes, Michael V., Lawlor, Debbie A., Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Langenberg, Claudia, Ben-Shlomo, Yoav, Wannamethee, S. Goya, Strachan, Mark W.J., Kumari, Meena, Whittaker, John C., Drenos, Fotios, Kivimaki, Mika, Hingorani, Aroon D., Price, Jacqueline F., and Humphries, Steve E.

Published
2015
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