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CASO CLINICOS.A.G. es una paciente de 1 ano 8 meses deedad portadora de una inmunodeficiencia detipo celular, que ha sufrido una serie de infec-ciones de diversa etiologfa y entre ellas la ma'sgrave, una generalizaci(5n de la vacuna BCG.La evoluci6n clmica esta resuroida en laTabla N? 1. Cabe destacar la complicacionlocal de la vacuna que se ulcera hasta alcan-zar un diametro de 3 cm. y se acompana deadenopatfa axilar que supura y finalmentedebe ser extirpada quirurgicamente.Las infecciones presentadas por esta nifiaeran catisadas por diversos agentes:1. Para"sitos: Giardia Lambia en deposicionesy que rectdiva pese al trataraiento.2. Virus: Estomatitis herrje'tica prolongada(de los 9 a 12 meses de edad).Varicela de curso ma's prolongado, perono severa.5. Bacterias: Bronconeumonia a los 10 me-ses.Infecci6n urinaria por E. Coli (quetambien recidiva).4. Nonpros; Una de las infecciones ma's seve-ras y de caracter cr6nico. Se inicia conaleorra bucal y lueero se extiende a zonapTuteoeenital. teiidos neribucales. dorso,cuello y cuero cabelludo. Se ais!6 Candida

INTRODUCCION. La IgA es el anticuerpo quese encuentra en mayor concentracion en las secre-ciones externas, hecho que le confrere un papelimportante en la respuesta inmune local frentea agentes infecciosos y como barrera para el in-greso de antigenos inertes (1, 2, 3, 4, 5, 6, 7).Su deficiencia esta. relacionada con la apari-cion de diversas patologias. Esto deriva tanto deuna mayor susceptibilidad a agentes infecciosos, co-mo de una deficiente barrera a antigenos extra-nos, hechos que ban sido discutidos en mayor de-talle en otros trabajos en esta misma revista, (8,9, 10, 11, 12, 13

Neonatal mitogen(M)induced lymphocyte proliferation reflects the hosts ability to develop a cellular immune reaction. Since LP and lymphokine release usually occur simultaneously and lymphokines enhance phagocytosis, LP suggests resistance to infection. To determine the influence of delivery on LP, we measured LP in vitro in 175 vaginally(vag) and 65 Cesarean section(CS)delivered neonates. LP/105 cord blood mononuclear cells was measured with a whole blood assay measuring tritiated thymidine incorporation(cpm). LP was significantly(p

Perinatal factors influencing diff of cord blood B lymphocytes into immunoglobulin secreting plasma cells was studied in 126 neonates with gestational ages(GA) from 20-44 wks. A plaque forming cell assay measured background B cell diff and diff in response to pokeweed mitogen(PWM)plus hydrocortisone(HC). 8 infants had a GA less than 27.9 wks, 24 had GA's 28-32.9 wks, 30 had GA's 33-37.9 wks, 51 had GA's 38-41.9 wks and 13 had GA's above 42wks. The mean±SD GA was 36±5wks and B.Wt. 2400±980gm. The mean±SD background plaque formation was 98±253 and in response to PWM+HC was 7505±11874/106 cord blood mononuclear cells. B cell diff was observed in some neonates in all GA groups. The magnitude of in vitro neonatal B cell diff undergoes a continuous and significant(p