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153. FCGR3A and FCGR2A Genotypes Differentially Impact Allograft Rejection and Patients' Survival After Lung Transplant

Author

Paul, Pascale, primary, Pedini, Pascal, additional, Lyonnet, Luc, additional, Di Cristofaro, Julie, additional, Loundou, Anderson, additional, Pelardy, Mathieu, additional, Basire, Agnes, additional, Dignat-George, Françoise, additional, Chiaroni, Jacques, additional, Thomas, Pascal, additional, Reynaud-Gaubert, Martine, additional, and Picard, Christophe, additional

Published
2019
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154. Widening the landscape of heritable pulmonary hypertension mutations in paediatric and adult cases

Author

Eyries, Mélanie, primary, Montani, David, additional, Nadaud, Sophie, additional, Girerd, Barbara, additional, Levy, Marilyne, additional, Bourdin, Arnaud, additional, Trésorier, Romain, additional, Chaouat, Ari, additional, Cottin, Vincent, additional, Sanfiorenzo, Céline, additional, Prevot, Grégoire, additional, Reynaud-Gaubert, Martine, additional, Dromer, Claire, additional, Houeijeh, Ali, additional, Nguyen, Karine, additional, Coulet, Florence, additional, Bonnet, Damien, additional, Humbert, Marc, additional, and Soubrier, Florent, additional

Published
2018
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155. Sepsis is associated with lack of monocyte HLA-DR expression recovery without modulating T-cell reconstitution after lung transplantation

Author

Alingrin, Julie, primary, Coiffard, Benjamin, additional, Textoris, Julien, additional, Nicolino-Brunet, Corine, additional, Gossez, Morgane, additional, Jarrot, Pierre-André, additional, Dignat-George, Françoise, additional, Monneret, Guillaume, additional, Thomas, Pascal Alexandre, additional, Leone, Marc, additional, Reynaud-Gaubert, Martine, additional, and Papazian, Laurent, additional

Published
2018
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156. Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage

Author

Boniface Stephanie, Reynaud-Gaubert Martine, Sarles Jacques, Dubus Jean-Christophe, Stremler Nathalie, Bosdure Emmanuelle, Mattenberger Yves, Fournous Ghislain, Richet Hervé, Bittar Fadi, Hernandez David, François Patrice, Rolain Jean-Marc, Schrenzel Jacques, and Raoult Didier

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Background Staphylococcus aureus is a major human pathogen responsible for a variety of nosocomial and community-acquired infections. Recent reports show that the prevalence of Methicillin-Resistant S. aureus (MRSA) infections in cystic fibrosis (CF) patients is increasing. In 2006 in Marseille, France, we have detected an atypical MRSA strain with a specific antibiotic susceptibility profile and a unique growth phenotype. Because of the clinical importance of the spread of such strain among CF patients we decided to sequence the genome of one representative isolate (strain CF-Marseille) to compare this to the published genome sequences. We also conducted a retrospective epidemiological analysis on all S. aureus isolated from 2002 to 2007 in CF patients from our institution. Results CF-Marseille is multidrug resistant, has a hetero-Glycopeptide-Intermediate resistance S. aureus phenotype, grows on Cepacia agar with intense orange pigmentation and has a thickened cell wall. Phylogenetic analyses using Complete Genome Hybridization and Multi Locus VNTR Assay showed that CF-Marseille was closely related to strain Mu50, representing vancomycin-resistant S. aureus. Analysis of CF-Marseille shows a similar core genome to that of previously sequenced MRSA strains but with a different genomic organization due to the presence of specific mobile genetic elements i.e. a new SCCmec type IV mosaic cassette that has integrated the pUB110 plasmid, and a new phage closely related to phiETA3. Moreover this phage could be seen by electron microscopy when mobilized with several antibiotics commonly used in CF patients including, tobramycin, ciprofloxacin, cotrimoxazole, or imipenem. Phylogenetic analysis of phenotypically similar h-GISA in our study also suggests that CF patients are colonized by polyclonal populations of MRSA that represents an incredible reservoir for lateral gene transfer. Conclusion In conclusion, we demonstrated the emergence and spreading of a new isolate of MRSA in CF patients in Marseille, France, that has probably been selected in the airways by antibiotic pressure. Antibiotic-mediated phage induction may result in high-frequency transfer and the unintended consequence of promoting the spread of virulence and/or antibiotic resistance determinants. The emergence of well-adapted MRSA is worrying in such population chronically colonized and receiving many antibiotics and represents a model for emergence of uncontrollable super bugs in a specific niche. Reviewers This article was reviewed by Eric Bapteste, Pierre Pontarotti, and Igor Zhulin. For the full reviews, please go to the Reviewers' comments section.

Published
2009
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158. Central venous thrombosis and thrombophilia in cystic fibrosis: A prospective study

Author

Isabelle Durieu, E. Darviot, J.-L. Giniès, Raphaele Nove-Josserand, Charlotte Giraut, Anne Munck, Marie-Francoise Hurtaud, Michael Fayon, Muriel Le Bourgeois, A. Sardet, Raphaël Chiron, Marlène Murris-Epin, Annelyse Fanton, B. Delaisi, Dominique Hubert, Laure Couderc, Corinne Alberti, Dominique Grenet, Frédéric Huet, Marie Laure Dalphin, Stéphanie Wanin, François Bremont, Stéphane Dominique, Françoise Varaigne, Reynaud-Gaubert Martine, Marcel Guillot, S. Ramel, Laurence Weiss, M. Gerardin, Ahmed Kheniche, Isabelle Pin, and Isabelle Sermet-Gaudelus

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, Cystic Fibrosis, Comorbidity, Thrombophilia, Severity of Illness Index, Asymptomatic, Cohort Studies, Young Adult, Age Distribution, Catheters, Indwelling, Prevalence, medicine, Humans, Medical history, Prospective Studies, Pediatrics, Perinatology, and Child Health, Sex Distribution, Child, Prospective cohort study, Venous Thrombosis, Catheter insertion, business.industry, Thrombosis, Ultrasonography, Doppler, Prognosis, medicine.disease, 3. Good health, Surgery, Venous thrombosis, Catheter, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business
Abstract

Background and Aims Catheter venous thrombosis may result in life-threatening embolic complications. Recently, a thrombophilic tendency was described in cystic fibrosis (CF), the significance of which remains unclear. The aims of this study were to (1) document the frequency of catheter venous thrombosis detected by colour-Doppler-ultrasound (Doppler-US), (2) assess genetic and acquired thrombophilia risk factors for catheter venous thrombosis and hypercoagulability status and (3) provide recommendations on laboratory screening when considering insertion of a totally implantable vascular access device (TIVAD) in CF patients. Methods We designed a multicentre prospective study in patients selected at the time of catheter insertion. Doppler-US was scheduled at 1 and 6months after insertion and before insertion in case of a previous central line. Blood samplings were drawn at insertion and at 1 and 6months later. Results One-hundred patients received a TIVAD and 90 completed the 6-month study. Prevalence of thrombophilia abnormalities and hypercoagulability was found in 50% of the cohorts. Conversely, catheter venous thrombosis frequency was low (6.6%). Conclusion Our data do not support biological screening at the time of a TIVAD insertion. We emphasise the contribution of a medical history of venous thromboembolism and prospective Doppler-US for identifying asymptomatic catheter venous thrombosis to select patients who may benefit from biological screening and possible anticoagulant therapy.

Published
2015
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159. Lung transplantation after allogeneic stem cell transplantation: a pan-European experience

Author

Greer, Mark, Berastegui, Cristina, Jaksch, Peter, Benden, Christian, Aubert, John D., Roux, Antoine, Lhuillier, Elodie, Hirschi, Sandrine, Reynaud-Gaubert, Martine, Philit, François, Claustre, Johanna, LePalud, Pierre, Stern, Marc, Knoop, Christiane, Vos, Robin, Verschuuren, Erik, Fisher, Andrew A.J., Riise, Gerdt, Hansson, Lennart, Iversen, Martin, Hämmäinen, Pekka, Wedel, Hans, Smits, Jacqueline M A J.M., Gottlieb, Jens, Holm, Are Martin, Greer, Mark, Berastegui, Cristina, Jaksch, Peter, Benden, Christian, Aubert, John D., Roux, Antoine, Lhuillier, Elodie, Hirschi, Sandrine, Reynaud-Gaubert, Martine, Philit, François, Claustre, Johanna, LePalud, Pierre, Stern, Marc, Knoop, Christiane, Vos, Robin, Verschuuren, Erik, Fisher, Andrew A.J., Riise, Gerdt, Hansson, Lennart, Iversen, Martin, Hämmäinen, Pekka, Wedel, Hans, Smits, Jacqueline M A J.M., Gottlieb, Jens, and Holm, Are Martin

Abstract

Late-onset noninfectious pulmonary complications (LONIPCs) affect 6% of allogeneic stem cell transplantation (SCT) recipients within 5 years, conferring subsequent 5-year survival of 50%. Lung transplantation is rarely performed in this setting due to concomitant extrapulmonary morbidity, excessive immunosuppression and concerns about recurring malignancy being considered contraindications. This study assesses survival in highly selected patients undergoing lung transplantation for LONIPCs after SCT.SCT patients undergoing lung transplantation at 20 European centres between 1996 and 2014 were included. Clinical data pre- and post-lung transplantation were reviewed. Propensity score-matched controls were generated from the Eurotransplant and Scandiatransplant registries. Kaplan-Meier survival analysis and Cox proportional hazard regression models evaluating predictors of graft loss were performed.Graft survival at 1, 3 and 5 years of 84%, 72% and 67%, respectively, among the 105 SCT patients proved comparable to controls (p=0.75). Sepsis accounted for 15 out of 37 deaths (41%), with prior mechanical ventilation (HR 6.9, 95% CI 1.0-46.7; p<0.001) the leading risk factor. No SCT-specific risk factors were identified. Recurring malignancy occurred in four patients (4%). Lung transplantation <2 years post-SCT increased all-cause 1-year mortality (HR 7.5, 95% CI 2.3-23.8; p=0.001).Lung transplantation outcomes following SCT were comparable to other end-stage diseases. Lung transplantation should be considered feasible in selected candidates. No SCT-specific factors influencing outcome were identified within this carefully selected patient cohort., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

160. COLT: 10 ans de recherche en transplantation pulmonaire, résultats et perspectives

Author

Tissot, Adrien, Foureau, Aurore, Brosseau, Carole, Danger, Richard, Roux, Antoine, Bernasconi, Eric, Gomez, Carine, Durand, Maxim, Picard, B.R., Le Pavec, Jérôme, Claustre, Johanna, Lacoste, Philippe, Benmerad, Meriem, Pain, Mallory, Siroux, Valérie, Royer, Pierre Joseph, Mordant, Pierre, Reynaud-Gaubert, Martine, Kessler, Romain, Brugiere, Olivier, Mornex, Jean-François, Dromer, Claire, Dahan, Marcel, Knoop, Christiane, Boussaud, Véronique, Koutsokera, Angela, Botturi-Cavaillès, K., Durand, Eugénie, Loy, Jennifer, Nicod, Laurent Pierre, Pison, Christophe, Brouard, Sophie, Blanc, François Xavier, Magnan, Antoine, Tissot, Adrien, Foureau, Aurore, Brosseau, Carole, Danger, Richard, Roux, Antoine, Bernasconi, Eric, Gomez, Carine, Durand, Maxim, Picard, B.R., Le Pavec, Jérôme, Claustre, Johanna, Lacoste, Philippe, Benmerad, Meriem, Pain, Mallory, Siroux, Valérie, Royer, Pierre Joseph, Mordant, Pierre, Reynaud-Gaubert, Martine, Kessler, Romain, Brugiere, Olivier, Mornex, Jean-François, Dromer, Claire, Dahan, Marcel, Knoop, Christiane, Boussaud, Véronique, Koutsokera, Angela, Botturi-Cavaillès, K., Durand, Eugénie, Loy, Jennifer, Nicod, Laurent Pierre, Pison, Christophe, Brouard, Sophie, Blanc, François Xavier, and Magnan, Antoine

Abstract

SCOPUS: ed.j, info:eu-repo/semantics/published

Published
2018

161. Discordant courses of COVID‐19 in a cohabiting couple of lung transplant recipients.

Author

Desmazes‐Dufeu, Nadine, Coltey, Bérengère, Amari, Lyria, Gouitaa, Marion, Touzery, Camille, Reynaud‐Gaubert, Martine, Chanez, Pascal, and Cassir, Nadim

Subjects
COVID-19, LUNG transplantation, SARS-CoV-2, DISEASE complications, VIRAL shedding, EMERGING infectious diseases
Abstract

COVID‐19 is a novel infectious disease caused by SARS‐CoV‐2 that emerged in late 2019 and which is now a pandemic. Solid organ transplant recipients are perceived to be at increased risk of severe COVID‐19 due to their chronic use of immunosuppressive drugs (ISDs) and to their associated conditions. Scarce data are available on the optimized management of ISDs in these patients and on its impact on presentation, clinical course, viral shedding, and outcome. We report here two cases of COVID‐19 in a cohabiting couple of lung transplant recipients for cystic fibrosis, who had different ISDs management and who developed discordant courses of their disease. Our findings suggest that the degree of their immunosuppression might be a reason for their different course and that ISDs might prove partially protective. [ABSTRACT FROM AUTHOR]

Published
2021
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162. Semi-automatic analysis of electroencephalogram in sleep apnea syndromes

Author

Philip-Joet, Francois F., Rey, Marc F., DiCroco, Andre A., Reynaud-Gaubert, Martine J., and Arnaud, Alain G.

Subjects
Sleep apnea syndromes -- Diagnosis, Electroencephalography -- Evaluation, Health, Diagnosis, Evaluation
Abstract

Study objective: The present study was undertaken to validate a system of condensed display of the sleep EEG spectral analysis with a view to simplifying sleep studies in patients affected [...]

Published
1993

163. Primary pulmonary lymphomas: a clinical study of 70 cases in nonimmunocompromised patients

Author

Cordier, Jean-Francois, Chailleux, Edmond, Lauque, Dominique, Reynaud-Gaubert, Martine, Dietemann-Molard, Anita, Dalphin, Jean Charles, Blanc-Jouvan, Francois, and Loire, Robert

Subjects
Lymphomas -- Development and progression -- Prognosis, Non-Hodgkin's lymphomas -- Prognosis -- Development and progression, Health, Development and progression, Prognosis
Abstract

We studied 70 patients with biopsy-proven pulmonary non-Hodgkin's lymphomas without extrathoracic involvement or mediastinal adenopathy to determine the clinical, imaging, and endoscopic features of this condition in a homogeneous series. [...]

Published
1993

164. Development of a multivariate prediction model for early-onset bronchiolitis obliterans syndrome and restrictive allograft syndrome in lung transplantation

Author

Koutsokera, Angela, Royer, Pierre J., Antonietti, Jean P., Fritz, Andreas, Benden, Christian, Aubert, John D., Tissot, Adrien, Botturi, Karine, Roux, Antoine, Reynaud-Gaubert, Martine L., Kessler, Romain, Dromer, Claire, Mussot, Sacha, Mal, Herve, Mornex, Jean-Francois, Guillemain, Romain, Knoop, Christiane, Dahan, Marcel, Soccal, Paola M., Claustre, Johanna, Sage, Edouard, Gomez, Carine, Magnan, Antoine, Pison, Christophe, Nicod, Laurent P., Chung, Kian, Wewers, Mark, Hillerdal, Gunnar, Division of Pulmonary Medicine, Medical University Vienna, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biomax Informatics AG, Division Pulmonary Medicine, University hospital of Zurich [Zurich], UPRES EA220, Service de Pneumologie, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), UPRES EA220, Lung Transplantation Department, Lung Transplantation Center, Hôpitaux Universitaires de Strasbourg, Service Maladies Respiratoires, Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardiopulmonaire, Hôpital Marie Lannelongue, INSERM UMR1152, Service de Pneumologie et Transplantation Pulmomaire, Hôpital Bichat - Claude Bernard, Assistance Publique - Hôpitaux de Paris (AP-HP), Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL), Department of Chest Medicine, Mont-Godinne Hospital-Catholic University of Louvain de Mont-Godinne, Hop Larrey, Geneva University Hospital (HUG), Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire de Grenoble, UPRES EA220, Thoracique Surgery Department, Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Centre Hospitalier Universitaire [Grenoble] (CHU), Nantes Metropole, Region Pays de la Loire, Swiss National Science Foundation, Swiss University Hospitals G15, Swiss National Research Foundation 3347CO-108795, ANR-10-IBHU-0005/10-IBHU-0005,CESTI (TSI-IHU),CESTI (TSI-IHU)(2010), European Project: 305457,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,SYSCLAD(2012), SysCLAD Consortium, De Geest, Sabina, Koutsokera, Angela, Medizinische Universität Wien = Medical University of Vienna, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Hôpital Marie-Lannelongue, Institut National de la Recherche Agronomique (INRA)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), ANR-10-IBHU-0005,CESTI (TSI-IHU),Centre Européen des Sciences de la Transplantation et de l'Immunothérapie (TSI-IHU)(2010), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], ProdInra, Archive Ouverte, Instituts Hospitalo-Universitaires B - Centre Européen des Sciences de la Transplantation et de l'Immunothérapie (TSI-IHU) - - CESTI (TSI-IHU)2010 - ANR-10-IBHU-0005 - IBHU - VALID, Systems prediction of Chronic Lung Allograft Dysfunction - SYSCLAD - - EC:FP7:HEALTH2012-11-01 - 2014-10-31 - 305457 - VALID, and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)

Subjects
medicine.medical_treatment, [SDV]Life Sciences [q-bio], bronchiolitis obliterans syndrome, 030230 surgery, Logistic regression, predictive model, 0302 clinical medicine, chronic lung allograft dysfunction, restrictive allograft syndrome, chronic rejection, Original Research, ddc:616, lcsh:R5-920, MINIMAL ACUTE REJECTION, Interstitial lung disease, Immunosuppression, General Medicine, humanities, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Cohort, SURVIVAL, HEART, Medicine, lcsh:Medicine (General), Life Sciences & Biomedicine, medicine.medical_specialty, Bronchiolitis obliterans, DIAGNOSIS, transplantation pulmonaire, 03 medical and health sciences, Medicine, General & Internal, INTERNATIONAL-SOCIETY, Internal medicine, General & Internal Medicine, medicine, Lung transplantation, Lung, Science & Technology, business.industry, Généralités, medicine.disease, DYSFUNCTION, Surgery, modèle prédictif, Institutional repository, 030228 respiratory system, REGISTRY, RISK-FACTORS, allogreffe, business, LYMPHOCYTIC BRONCHIOLITIS, BASILIXIMAB
Abstract

Background: Chronic lung allograft dysfunction and its main phenotypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), are major causes of mortality after lung transplantation (LT). RAS and early-onset BOS, developing within 3 years after LT, are associated with particularly inferior clinical outcomes. Prediction models for early-onset BOS and RAS have not been previously described. Methods: LT recipients of the French and Swiss transplant cohorts were eligible for inclusion in the SysCLAD cohort if they were alive with at least 2 years of follow-up but less than 3 years, or if they died or were retransplanted at any time less than 3 years. These patients were assessed for early-onset BOS, RAS, or stable allograft function by an adjudication committee. Baseline characteristics, data on surgery, immunosuppression, and year-1 follow-up were collected. Prediction models for BOS and RAS were developed using multivariate logistic regression and multivariate multinomial analysis. Results: Among patients fulfilling the eligibility criteria, we identified 149 stable, 51 BOS, and 30 RAS subjects. The best prediction model for early-onset BOS and RAS included the underlying diagnosis, induction treatment, immunosuppression, and year-1 class II donor-specific antibodies (DSAs). Within this model, class II DSAs were associated with BOS and RAS, whereas pre-LT diagnoses of interstitial lung disease and chronic obstructive pulmonary disease were associated with RAS. Conclusion: Although these findings need further validation, results indicate that specific baseline and year-1 parameters may serve as predictors of BOS or RAS by 3 years post-LT. Their identification may allow intervention or guide risk stratification, aiming for an individualized patient management approach., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017
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165. Cystic fibrosis respiratory tract salt concentration An Exploratory Cohort Study

Author

Lapierre, Simon Grandjean, Phelippeau, Michael, Hakimi, Cyrine, Didier, Quentin, Reynaud-Gaubert, Martine, Dubus, Jean-Christophe, Drancourt, Michel, COMBE, Isabelle, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), and INSB-INSB-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; In cystic fibrosis patients, electrolytic and osmolality imbalance secondary to cystic fibrosis transmembrane conductance regulator mutations may impact on mucoid secretion accumulation and secondary colonization by opportunistic pathogens such as nontuberculous mycobacteria. We performed a noninvasive exploratory prospective controlled clinical study comparing sputum salinity and acid-base characteristics of cystic fibrosis and noncystic fibrosis control patients. A total of 57 patients and 62 controls were included. Sputum salt concentrations were 10.5 g/L (95% CI: 7.7-13.3) in patients and 7.4 g/L (95% CI: 5.9-8.9) in aged-matched controls, a difference that was found to be statistically significant (P

Published
2017
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166. Contribution of mutations in genes of the surfactant system to idiopathic interstitial pneumonia (IIP)

Author

Nathan, Nadia, primary, Legendre, Marie, additional, Filhol-Blin, Emilie, additional, Borie, Raphael, additional, Bouvry, Diane, additional, Afanetti, Mickael, additional, Ahmad, Kais, additional, Albuisson, Juliette, additional, Allou, Nathalie, additional, Bailly, Carole, additional, Borensztajn, Keren, additional, Butt, Afifaa, additional, Copin, Bruno, additional, Coulomb L'Hermine, Aurore, additional, Crestani, Bruno, additional, Dalphin, Jean-Charles, additional, Dalphin, Marie-Laure, additional, Dastot Le Moal, Florence, additional, Delacourt, Christophe, additional, Delaisi, Bertrand, additional, Deschildre, Antoine, additional, De Vuyst, Paul, additional, Diot, Bruno, additional, Dromer, Claire, additional, Dubus, Jean-Christophe, additional, Duquesnoy, Philippe, additional, Giovannini-Chami, Lisa, additional, Giraud, Violaine, additional, Gomez, Carine, additional, Gondouin, Anne, additional, Gouya, Laurent, additional, Hadchouel, Alice, additional, Hirschi, Sandrine, additional, Houdouin, Veronique, additional, Israel Biet, Dominique, additional, Kannengiesser, Caroline, additional, Lefevre, Claire, additional, Manali, Effrosyne, additional, Marchand-Adam, Sylvain, additional, Marguet, Christophe, additional, Naccache, Jean-Marc, additional, Nau, Valerie, additional, Nunes, Hilario, additional, O'Connell, Oisin, additional, O'Reilly, Katherine, additional, Papiris, Spyros, additional, Picard, Clement, additional, Prevot, Gregoire, additional, Reix, Philippe, additional, Reynaud-Gaubert, Martine, additional, Rivaud, Elisabeth, additional, Schaefer, Elise, additional, Tatopoulos, Aurelie, additional, Traclet, Julie, additional, Troussier, Françoise, additional, Valeyre, Dominique, additional, Cottin, Vincent, additional, Clement, Annick, additional, and Amselem, Serge, additional

Published
2018
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167. Pulmonary hypertension in patients with idiopathic pulmonary fibrosis and combined pulmonary fibrosis and emphysema: hemodynamic severity

Author

Graziani, Maria Laura, primary, Reynaud-Gaubert, Martine, additional, Gomez, Emmanuel, additional, Traclet, Julie, additional, Ahmad, Kaïs, additional, Bergot, Emmanuel, additional, Bertoletti, Laurent, additional, Camara, Boubou, additional, Israël-Biet, Dominique, additional, Jaïs, Xavier, additional, Kiakouama-Maleka, Lize, additional, Marchand-Adam, Sylvain, additional, Montani, David, additional, Nieves, Anna, additional, Nunes, Hilario, additional, Piegay, Fabrice, additional, Wemeau-Stervinou, Lidwine, additional, Zarza, Virginie, additional, Polazzi, Stéphanie, additional, Schott-Pethelaz, Anne-Marie, additional, Zeghmar, Sabrina, additional, Nasser, Mouhamad, additional, and Cottin, Vincent, additional

Published
2018
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168. Functional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer

Author

Nathan, Nadia, primary, Legendre, Marie, additional, Filhol-Blin, Emilie, additional, Borie, Raphael, additional, Bouvry, Diane, additional, Kannengiesser, Caroline, additional, Ahmad, Kais, additional, Albuisson, Juliette, additional, Allou, Nathalie, additional, Borensztajn, Keren, additional, Butt, Afifaa, additional, Copin, Bruno, additional, Cottin, Vincent, additional, Crestani, Bruno, additional, Dalphin, Jean-Charles, additional, Dastot Le Moal, Florence, additional, Delacourt, Christophe, additional, De Vuyst, Paul, additional, Duquesnoy, Philippe, additional, Giraud, Violaine, additional, Gomez, Carine, additional, Gouya, Laurent, additional, Nau, Valerie, additional, Nunes, Hilario, additional, Picard, Clement, additional, Prevot, Gregoire, additional, Reix, Philippe, additional, Reynaud-Gaubert, Martine-Louise, additional, Traclet, Julie, additional, Coulomb L'Hermine, Aurore, additional, Clement, Annick, additional, and Amselem, Serge, additional

Published
2018
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170. Natural Killer Cells Exhibit a Peculiar Phenotypic Profile in Systemic Sclerosis and Are Potent Inducers of Endothelial Microparticles Release

Author

Benyamine, Audrey, primary, Magalon, Jérémy, additional, Sabatier, Florence, additional, Lyonnet, Luc, additional, Robert, Stéphane, additional, Dumoulin, Chloé, additional, Morange, Sophie, additional, Mazodier, Karin, additional, Kaplanski, Gilles, additional, Reynaud-Gaubert, Martine, additional, Rossi, Pascal, additional, Dignat-George, Françoise, additional, Granel, Brigitte, additional, and Paul, Pascale, additional

Published
2018
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172. High circulating CD4 + CD25 hi FOXP3 + T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome

Author

Durand, Maxim, primary, Lacoste, Philippe, additional, Danger, Richard, additional, Jacquemont, Lola, additional, Brosseau, Carole, additional, Durand, Eugénie, additional, Tilly, Gaelle, additional, Loy, Jennifer, additional, Foureau, Aurore, additional, Royer, Pierre-Joseph, additional, Tissot, Adrien, additional, Roux, Antoine, additional, Reynaud-Gaubert, Martine, additional, Kessler, Romain, additional, Mussot, Sacha, additional, Dromer, Claire, additional, Brugière, Olivier, additional, Mornex, Jean François, additional, Guillemain, Romain, additional, Claustre, Johanna, additional, Degauque, Nicolas, additional, Magnan, Antoine, additional, and Brouard, Sophie, additional

Published
2018
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173. Safety and efficacy of pirfenidone in patients carrying telomerase complex mutation

Author

Justet, Aurélien, primary, Thabut, Gabriel, additional, Manali, Effrosyni, additional, Molina Molina, Maria, additional, Kannengiesser, Caroline, additional, Cadranel, Jacques, additional, Cottin, Vincent, additional, Gondouin, Anne, additional, Nunes, Hilario, additional, Magois, Eline, additional, Tromeur, Cécile, additional, Prevot, Grégoire, additional, Papiris, Spyros, additional, Marchand-Adam, Sylvain, additional, Gamez, Anne Sophie, additional, Reynaud-Gaubert, Martine, additional, Wemeau, Lidwine, additional, Crestani, Bruno, additional, and Borie, Raphael, additional

Published
2018
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174. Lung transplantation after allogeneic stem cell transplantation: a pan-European experience

Author

Greer, Mark, primary, Berastegui, Cristina, additional, Jaksch, Peter, additional, Benden, Christian, additional, Aubert, John, additional, Roux, Antoine, additional, Lhuillier, Elodie, additional, Hirschi, Sandrine, additional, Reynaud-Gaubert, Martine, additional, Philit, François, additional, Claustre, Johanna, additional, LePalud, Pierre, additional, Stern, Marc, additional, Knoop, Christiane, additional, Vos, Robin, additional, Verschuuren, Erik, additional, Fisher, Andrew, additional, Riise, Gerdt, additional, Hansson, Lennart, additional, Iversen, Martin, additional, Hämmäinen, Pekka, additional, Wedel, Hans, additional, Smits, Jacqueline, additional, Gottlieb, Jens, additional, and Holm, Are M., additional

Published
2018
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176. Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial

Author

Saiag, P., Gutzmer, R., Ascierto, P., Maio, M., Grob, J.-J., Murawa, P., Dréno, B., Ross, M., Weber, J., Hauschild, A., Rutkowski, P., Testori, A., Levchenko, E., Enk, A., Misery, L., Vanden Abeele, C., Vojtek, I., Peeters, O., Brichard, V., Therasse, P., Samier-Guérin, Anne, Saraux, Alain, Gestin, Simon, Cornec, Divi, Marhadour, Thierry, Devauchelle-Pensec, Valérie, Bressollette, Luc, Nonent, Michel, Jousse-Joulin, Sandrine, Sanges, Sébastien, Launay, David, Rhee, Rennie, Sitbon, Olivier, Hachulla, Eric, Mouthon, Luc, Guillevin, Loïc, Rottat, Laurence, Montani, David, de Groote, Pascal, Cottin, Vincent, Magro, Pascal, Prevot, Gregoire, Bauer, Fabrice, Bergot, Emmanuel, Chabanne, Céline, Reynaud-Gaubert, Martine, Leroy, Sylvie, Canuet, Matthieu, Sanchez, Olivier, Gut-Gobert, Christophe, Dauphin, Claire, Pison, Christophe, Boissin, Clement, Habib, Gilbert, Clerson, Pierre, Conesa, François, Cordier, François, Kawut, Steven, Simonneau, Gerald, Humbert, Marc, Santagostino, Elena, Martinowitz, Uri, Lissitchkov, Toshko, Pan-Petesch, Brigitte, Hanabusa, Hideji, Oldenburg, Johannes, Boggio, Lisa, Negrier, Claude, Pabinger, Ingrid, von Depka Prondzinski, Mario, Altisent, Carmen, Castaman, Giancarlo, Yamamoto, Koji, Álvarez-Roman, Maria-Teresa, Voigt, Christine, Blackman, Nicole, Jacobs, Iris, Hôpital Ambroise Paré [AP-HP], Skin Cancer Center Hannover, Hannover Medical School [Hannover] (MHH), Hôpital de la Timone [CHU - APHM] (TIMONE), Poznań University of Medical Sciences, Poznan University of Medical Sciences, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), University of Kiel, UKSH, Maria Sklodowska Curie Memorial Center and Institute of Oncology, Division of Melanoma and Muscolocutaneous sarcoma, European Institute of Oncology, Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), GSK Vaccines - Belgium, Département de radiologie [Brest] (DR - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Unité d'Echo-Doppler et de Médecine Vasculaire (BREST - ED MV), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Centre Hospitalier Universitaire de Lille (CHU de Lille), Service de médecine interne [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Centre chirurgical Marie Lannelongue, Department of Pneumology [Lyon], Hospices Civils de Lyon (HCL), Service de pneumologie [Toulouse], CHU Toulouse [Toulouse]-Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], Service de cardiologie [CHU Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service de pneumologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Pontchaillou [Rennes], Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre de Ressources et de Compétences en Mucoviscidose [Nice] (CRCM [Nice]), Les Hôpitaux Pédiatriques de Nice CHU-Lenval, Service de pneumologie (Strasbourg), CHU Strasbourg-Nouvel Hôpital Civil, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de Médecine Interne [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Orgamétrie biostatistiques, Service de pneumologie et Réanimation Respiratoire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre-DHU Thorax Innovation, Hôpital Morvan [Brest], CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, University of Bonn, Centre Hospitalier Universitaire de Lyon (CHU Lyon), Division of Haematology and Haemostaseology, Department of Medicine I, Medizinische Universität Wien = Medical University of Vienna, Department of Cell Therapy and Hematology, San Bortolo Hospital, Calvez, Ghislaine, Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Chirurgical Marie Lannelongue (CCML), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), and Universität Bonn = University of Bonn

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2016

177. HLA-E(⁎)01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence

Author

Di Cristofaro, Julie, Pelardy, Mathieu, Loundou, Anderson, Basire, Agnès, Gomez, Carine, Chiaroni, Jacques, Thomas, Pascal, Reynaud-Gaubert, Martine, Picard, Christophe, Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Unité d'Aide Méthodologique, Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille, Hôpital Nord [CHU - APHM], Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Vaincre la Mucoviscidose' through Funding 'TP1008.', and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
lcsh:Immunologic diseases. Allergy, Adult, Graft Rejection, Male, Article Subject, Genotype, Graft Survival, Histocompatibility Antigens Class I, Middle Aged, Allografts, Prognosis, Polymorphism, Single Nucleotide, Survival Analysis, Transplant Recipients, Young Adult, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Gene Frequency, Clinical Study, [SDV.IMM]Life Sciences [q-bio]/Immunology, Humans, Female, lcsh:RC581-607, Alleles, Lung Transplantation, Retrospective Studies
Abstract

International audience; Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. Two nonsynonymous alleles, HLA-E(⁎)01:01 and HLA-E(⁎)01:03, have functional differences, involving relative peptide affinity, cell surface expression, and potential lytic activity of NK cells. The aim of this retrospective study was to determine the impact of these two alleles for LTx recipients on anti-HLA alloimmunization risk, overall survival, and chronic rejection (CLAD). HLA-E was genotyped in 119 recipients who underwent LTx from 1998 to 2010 in a single transplantation center. In univariate analysis, both HLA-E homozygous states were associated with impaired overall survival compared to heterozygous HLA-E alleles (p = 0.01). In multivariate analysis, HLA-E(⁎)01:03 allele showed increased CLAD occurrence when compared to homozygous HLA-E(⁎)01:01 status (HR: 3.563 (CI 95%, 1.016-12), p = 0.047). HLA-E allele did not affect pathogen infection or the production of de novo DSA. This retrospective study shows an uninvestigated, deleterious association of HLA-E alleles with LTx and requires verification using a larger cohort.

Published
2016
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179. Management and long-term outcomes of sarcoidosis-associated pulmonary hypertension

Author

Boucly, Athénaïs, primary, Cottin, Vincent, additional, Nunes, Hilario, additional, Jaïs, Xavier, additional, Tazi, Abdelatif, additional, Prévôt, Grégoire, additional, Reynaud-Gaubert, Martine, additional, Dromer, Claire, additional, Viacroze, Catherine, additional, Horeau-Langlard, Delphine, additional, Pison, Christophe, additional, Bergot, Emmanuel, additional, Traclet, Julie, additional, Weatherald, Jason, additional, Simonneau, Gérald, additional, Valeyre, Dominique, additional, Montani, David, additional, Humbert, Marc, additional, Sitbon, Olivier, additional, and Savale, Laurent, additional

Published
2017
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180. SFTPA mutations in interstitial lung disease (ILD) and lung cancer

Author

Nathan, Nadia, primary, Legendre, Marie, additional, Kannengiesser, Caroline, additional, Albuisson, Juliette, additional, Borie, Raphaël, additional, Bouvry, Diane, additional, Copin, Bruno, additional, Crestani, Bruno, additional, Dalphin, Jean-Charles, additional, Dastot Le Moal, Florence, additional, De Vuyst, Paul, additional, Duquesnoy, Philippe, additional, Filhol-Blin, Emilie, additional, Giraud, Violaine, additional, Gomez, Carine, additional, Gouya, Laurent, additional, Jeunemaître, Xavier, additional, Nau, Valérie, additional, Nunes, Hilario, additional, Picard, Clément, additional, Prevost, Grégoire, additional, Reynaud-Gaubert, Martine, additional, Amselem, Serge, additional, and Clement, Annick, additional

Published
2017
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181. Multivariate Analysis As a Support for Diagnostic Flowcharts in Allergic Bronchopulmonary Aspergillosis: A Proof-of-Concept Study

Author

Vitte, Joana, primary, Ranque, Stéphane, additional, Carsin, Ania, additional, Gomez, Carine, additional, Romain, Thomas, additional, Cassagne, Carole, additional, Gouitaa, Marion, additional, Baravalle-Einaudi, Mélisande, additional, Bel, Nathalie Stremler-Le, additional, Reynaud-Gaubert, Martine, additional, Dubus, Jean-Christophe, additional, Mège, Jean-Louis, additional, and Gaudart, Jean, additional

Published
2017
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182. Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study

Author

Benmerad, Meriem, primary, Slama, Rémy, additional, Botturi, Karine, additional, Claustre, Johanna, additional, Roux, Antoine, additional, Sage, Edouard, additional, Reynaud-Gaubert, Martine, additional, Gomez, Carine, additional, Kessler, Romain, additional, Brugière, Olivier, additional, Mornex, Jean-François, additional, Mussot, Sacha, additional, Dahan, Marcel, additional, Boussaud, Véronique, additional, Danner-Boucher, Isabelle, additional, Dromer, Claire, additional, Knoop, Christiane, additional, Auffray, Annick, additional, Lepeule, Johanna, additional, Malherbe, Laure, additional, Meleux, Frederik, additional, Nicod, Laurent, additional, Magnan, Antoine, additional, Pison, Christophe, additional, and Siroux, Valérie, additional

Published
2016
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183. Additional file 1: Table S1. of Prevalence of Mycobacterium lentiflavum in cystic fibrosis patients, France

Author

Phelippeau, Michael, Jean-Christophe Dubus, Reynaud-Gaubert, Martine, Gomez, Carine, Bel, Nathalie Stremler Le, Bedotto, Marielle, Prudent, Elsa, and Drancourt, Michel

Subjects
body regions, nervous system, fungi
Abstract

Mycobacterium species tested for the specificity/sensitivity assay of real-time PCR for M. lentiflavum species. (PDF 43Â kb)

Published
2015
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184. Additional file 2: Figure S1. of Prevalence of Mycobacterium lentiflavum in cystic fibrosis patients, France

Author

Phelippeau, Michael, Jean-Christophe Dubus, Reynaud-Gaubert, Martine, Gomez, Carine, Bel, Nathalie Stremler Le, Bedotto, Marielle, Prudent, Elsa, and Drancourt, Michel

Abstract

Clinical and microbiological data concerning two cystic fibrosis patients who yielded more than one M. lentiflavum isolate and who may fulfill the American Thoracic Societyâ s clinical and microbiological criteria for NTM lung infection. BMI: Body Mass Index. (PDF 121Â kb)

Published
2015
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185. Erratum à « Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique » Rev. Mal. Respir. 30 (10) 879—902]

Author

Cottin, Vincent, Crestani, Bruno, Valeyre, Dominique, Wallaert, Benoît, Cadranel, Jacques, Dalphin, Jean Charles, Delaval, Philippe, Israël-Biet, Dominique, Kessler, Romain, Reynaud-Gaubert, Martine, Cordier, Jean-François, Aguilaniu, Bernard, Bouquillon, Benoit, Carré, Philippe, Danel, Claire, Faivre, Jean Baptiste, Ferretti, Gilbert, Just, Nicolas, Kouzan, Serge, Lebargy, François, Marchand Adam, Sylvain, Philippe, Bruno, Prevot, Grégoire, Stach, Bruno, Thivolet-Bejui, Françoise, Rétrovirus et Pathologie Comparée, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Centre de compétences pour les maladies pulmonaires rares, Clinique du Mail, Opened Mind Health and Associatesix, Polyclinique Montréal, Partenaires INRAE, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Albert Calmette, Hôpital Michallon, Centre Hospitalier Victor Provo, Centre Hospitalier Intercommunal, Hôpital Maison Blanche, Hôpital Bretonneau, Assistance Publique - Hôpitaux de Paris (AP-HP), Centre Hospitalier René Dubos [Pontoise], Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], Cabinet médical, and Hospices Civils de Lyon (HCL)

Subjects
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract

Une erreur s’est glissée dans l’orthographe du nom de l’auteur G. Ferretti.; National audience

Published
2014
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186. Prevalence and characteristics of TERT and TERC mutations in suspected genetic pulmonary fibrosis

Author

Borie, Raphael, primary, Tabèze, Laure, additional, Thabut, Gabriel, additional, Nunes, Hilario, additional, Cottin, Vincent, additional, Marchand-Adam, Sylvain, additional, Prevot, Grégoire, additional, Tazi, Abdellatif, additional, Cadranel, Jacques, additional, Mal, Herve, additional, Wemeau-Stervinou, Lidwine, additional, Bergeron Lafaurie, Anne, additional, Israel-Biet, Dominique, additional, Picard, Clement, additional, Reynaud Gaubert, Martine, additional, Jouneau, Stephane, additional, Naccache, Jean-Marc, additional, Mankikian, Julie, additional, Ménard, Christelle, additional, Cordier, Jean-François, additional, Valeyre, Dominique, additional, Reocreux, Marion, additional, Grandchamp, Bernard, additional, Revy, Patrick, additional, Kannengiesser, Caroline, additional, and Crestani, Bruno, additional

Published
2016
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187. GermlineSFTPA1mutation in familial idiopathic interstitial pneumonia and lung cancer

Author

Nathan, Nadia, primary, Giraud, Violaine, additional, Picard, Clément, additional, Nunes, Hilario, additional, Dastot Le Moal, Florence, additional, Duquesnoy, Philippe, additional, Copin, Bruno, additional, Reynaud Gaubert, Martine, additional, Valeyre, Dominique, additional, Couderc, Louis-Jean, additional, Chinet, Thierry, additional, Borie, Raphaël, additional, Crestani, Bruno, additional, Nau, Valérie, additional, Tissier, Sylvie, additional, Galeron, Laurie, additional, De Ligniville, Alice, additional, Kuziner, Nathalie, additional, Simansour, Maud, additional, Mansour Hendili, Lamisse, additional, Legendre, Marie, additional, Kannengiesser, Caroline, additional, Coulomb, Aurore, additional, Gouya, Laurent, additional, Amselem, Serge, additional, and Clement, Annick, additional

Published
2016
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188. Severe Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)

Author

Picard, Cécile, primary, Thouvenin, Guillaume, additional, Kannengiesser, Caroline, additional, Dubus, Jean-Christophe, additional, Jeremiah, Nadia, additional, Rieux-Laucat, Frédéric, additional, Crestani, Bruno, additional, Belot, Alexandre, additional, Thivolet-Béjui, Françoise, additional, Secq, Véronique, additional, Ménard, Christelle, additional, Reynaud-Gaubert, Martine, additional, and Reix, Philippe, additional

Published
2016
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189. Dichotomy in pulmonary graft-versus-host disease evident among allogeneic stem-cell transplant recipients undergoing lung transplantation

Author

Greer, Mark, primary, Riise, Gerdt C., additional, Hansson, Lennart, additional, Perch, Michael, additional, Hämmäinen, Pekka, additional, Roux, Antoine, additional, Hirschi, Sandrine, additional, Lhuillier, Elodie, additional, Reynaud-Gaubert, Martine, additional, Philit, Francois, additional, Claustre, Johanna, additional, Stern, Marc, additional, Gottlieb, Jens, additional, and Holm, Are M., additional

Published
2016
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191. Aspergillus tubingensis: a major filamentous fungus found in the airways of patients with lung disease

Author

Gautier, Magali, primary, Normand, Anne-Cécile, additional, L'Ollivier, Coralie, additional, Cassagne, Carole, additional, Reynaud-Gaubert, Martine, additional, Dubus, Jean-Christophe, additional, Brégeon, Fabienne, additional, Hendrickx, Marijke, additional, Gomez, Carine, additional, Ranque, Stéphane, additional, and Piarroux, Renaud, additional

Published
2016
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192. Blood CD9+B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Author

Brosseau, Carole, Danger, Richard, Durand, Maxim, Durand, Eugénie, Foureau, Aurore, Lacoste, Philippe, Tissot, Adrien, Roux, Antoine, Reynaud-Gaubert, Martine, Kessler, Romain, Mussot, Sacha, Dromer, Claire, Brugière, Olivier, Mornex, Jean François, Guillemain, Romain, Claustre, Johanna, Magnan, Antoine, and Brouard, Sophie

Abstract

Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow-up. CD24hiCD38hitransitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hiCD38hitransitional B cells specifically secrete IL-10 and express CD9. Thus, patients with a total CD9+B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL-10-secreting CD24hiCD38hitransitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9-expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long-term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival.

Published
2019
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193. Acetobacter indonesiensis pneumonia after lung transplant

Author

Bittar, Fadi, Reynaud-Gaubert, Martine, Thomas, Pascal, Boniface, Stephanie, Raoult, Didier, and Rolain, Jean-Marc

Abstract

To the Editor: Unusual and multiresistant bacterial infections are increasingly reported in cystic fibrosis (CF) patients (1). On January 25, 2007, a 31-year-old man with CF (mutation [DELTA]F 508 and [...]

Published
2008

195. Adherence to guidelines in idiopathic pulmonary fibrosis: a follow-up national survey

Author

Cottin, Vincent, primary, Bergot, Emmanuel, additional, Bourdin, Arnaud, additional, Cadranel, Jacques, additional, Camus, Philippe, additional, Crestani, Bruno, additional, Dalphin, Jean-Charles, additional, Delaval, Philippe, additional, Dromer, Claire, additional, Israel-Biet, Dominique, additional, Kessler, Romain, additional, Marchand-Adam, Sylvain, additional, Marquette, Charles Hugo, additional, Prévot, Grégoire, additional, Reynaud-Gaubert, Martine, additional, Valeyre, Dominique, additional, Wallaert, Benoit, additional, Bouquillon, Benoit, additional, and Cordier, Jean-François, additional

Published
2015
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196. Blood mRNA and miRNA transcriptome to predict chronic lung allograft dysfunction

Author

Royer, Pierre-Joseph, primary, Baron, Daniel, additional, Reboulleau, Damien, additional, Tissot, Adrien, additional, Botturi-Cavailles, Karine, additional, Roux, Antoine, additional, Reynaud-Gaubert, Martine, additional, Kessler, Romain, additional, Mussot, Sacha, additional, Dromer, Claire, additional, Brugière, Olivier, additional, Mornex, Jean-Francois, additional, Guillemain, Romain, additional, Dahan, Marcel, additional, Knoop, Christiane, additional, Pison, Christophe, additional, Koutsokera, Angela, additional, Nicod, Laurent, additional, Brouard, Sophie, additional, and Magnan, Antoine, additional

Published
2015
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197. Genetic testing in idiopathic interstitial pneumonia

Author

Nathan, Nadia, primary, Borie, Raphaël, additional, Kannengiesser, Caroline, additional, Dastot Le Moal, Florence, additional, Nunes, Hilario, additional, Valeyre, Dominique, additional, Reynaud-Gaubert, Martine, additional, Marchand-Adam, Sylvain, additional, Naccache, Jean-Marc, additional, Prevot, Grégoire, additional, Lezmi, Guillaume, additional, Delacourt, Christophe, additional, Israël Biet, Dominique, additional, Thumerelle, Caroline, additional, Deschildre, Antoine, additional, Marguet, Christophe, additional, Reix, Philippe, additional, Cottin, Vincent, additional, Dalphin, Marie-Laure, additional, Gondouin, Anne, additional, Picard, Clément, additional, Giraud, Violaine, additional, Dromer, Claire, additional, Legendre, Marie, additional, Gouya, Laurent, additional, Crestani, Bruno, additional, Clement, Annick, additional, and Amselem, Serge, additional

Published
2015
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199. A prospective study of the 6 min walk test as a surrogate marker for haemodynamics in two independent cohorts of treatment-naïve systemic sclerosis-associated pulmonary arterial hypertension

Author

Sanges, Sébastien, primary, Launay, David, additional, Rhee, Rennie L, additional, Sitbon, Olivier, additional, Hachulla, Éric, additional, Mouthon, Luc, additional, Guillevin, Loïc, additional, Rottat, Laurence, additional, Montani, David, additional, De Groote, Pascal, additional, Cottin, Vincent, additional, Magro, Pascal, additional, Prévot, Grégoire, additional, Bauer, Fabrice, additional, Bergot, Emmanuel, additional, Chabanne, Céline, additional, Reynaud-Gaubert, Martine, additional, Leroy, Sylvie, additional, Canuet, Matthieu, additional, Sanchez, Olivier, additional, Gut-Gobert, Christophe, additional, Dauphin, Claire, additional, Pison, Christophe, additional, Boissin, Clément, additional, Habib, Gilbert, additional, Clerson, Pierre, additional, Conesa, François, additional, Cordier, Jean-François, additional, Kawut, Steven M, additional, Simonneau, Gerald, additional, and Humbert, Marc, additional

Published
2015
Full Text
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