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1,045 results on '"Ren, Fazheng"'

152. Correction: Liu et al. Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination. Foods 2024, 13 , 41.

Author

Liu, Guangmin, He, Hongju, Wang, Pengjie, Zhao, Xirui, and Ren, Fazheng

Subjects
BROCCOLI, MESSENGER RNA, GERMINATION, AUTHORS
Abstract

In the original publication [[1]], there was a mistake in Figure 6 as published. The result of "AOP3 relative mRNA abundance" has a repeated occurrence in Figure 6. The 12th figure of Figure 6 should be the result of "MYR relative mRNA abundance". The corrected Figure 6 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.GraphBy Guangmin Liu; Hongju He; Pengjie Wang; Xirui Zhao and Fazheng RenReported by Author; Author; Author; Author; Author [Extracted from the article]

Published
2024
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157. Prolonged Efficacy of Bifidobacterium Lactis in the Treatment of Functional Dyspepsia: A Randomized, Positive-Drug and Placebo-Controlled Clinical Trial

Author

Zhang, Qi, primary, Li, Guang, additional, Zhao, Wen, additional, Zhou, Limian, additional, Zhang, Xiaoxu, additional, He, Jingjing, additional, An, Peng, additional, Liu, Yinghua, additional, Zhang, Chengying, additional, Zhang, Yong, additional, Liu, Simin, additional, Liu, Wei-Hsien, additional, Liu, Fudong, additional, Li, Yixuan, additional, Jiang, Wenjian, additional, Wang, Xifan, additional, Wang, Xiaoyu, additional, Wang, Qingyu, additional, Fang, Bing, additional, Guo, Meng, additional, Zhao, Yuyang, additional, Ren, Yimei, additional, Niu, Xiaokang, additional, Li, Dongjie, additional, Zhang, Chao, additional, Shi, Shaoqi, additional, Wang, Ran, additional, Liu, Xinjuan, additional, Hung, Wei-Lian, additional, and Ren, Fazheng, additional

Published
2022
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163. Insights into diet-associated oxidative pathomechanisms in inflammatory bowel disease and protective effects of functional amino acids.

Author

Ji, Yun, Yang, Ying, Sun, Shiqiang, Dai, Zhaolai, Ren, Fazheng, and Wu, Zhenlong

Subjects
AMINO acid metabolism, DISEASE progression, ONLINE information services, GLUTATHIONE, STAT proteins, INFLAMMATORY bowel diseases, NUCLEAR factor E2 related factor, SYSTEMATIC reviews, DIET, ANTIOXIDANTS, RISK assessment, OXIDATIVE stress, CELLULAR signal transduction, ENTEROBACTERIACEAE, JANUS kinases, DIETARY sucrose, IMMUNITY, ENZYMES, MOLECULAR structure, MEDLINE, REACTIVE oxygen species, MITOGEN-activated protein kinases, OXIDATION-reduction reaction, DIETARY proteins, DISEASE risk factors
Abstract

There has been a substantial rise in the incidence and prevalence of clinical patients presenting with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Accumulating evidence has corroborated the view that dietary factors (particularly diets with high levels of saturated fat or sugar) are involved in the development and progression of IBD, which is predominately associated with changes in the composition of the gut microbiota and an increase in the generation of reactive oxygen species. Notably, the ecological imbalance of the gut microbiome exacerbates oxidative stress and inflammatory responses, leading to perturbations of the intestinal redox balance and immunity, as well as mucosal integrity. Recent findings have revealed that functional amino acids, including L-glutamine, glycine, L-arginine, L-histidine, L-tryptophan, and hydroxyproline, are effectively implicated in the maintenance of intestinal redox and immune homeostasis. These amino acids and their metabolites have oxygen free-radical scavenging and inflammation-relieving properties, and they participate in modulation of the microbial community and the metabolites in the gut. The principal focus of this article is a review of recent advances in the oxidative pathomechanisms of IBD development and progression in relation to dietary factors, with a particular emphasis on the redox and signal transduction mechanisms of host cells in response to unbalanced diets and enterobacteria. In addition, an update on current understanding of the protective effects of functional amino acids against IBD, together with the underlying mechanisms for this protection, have been provided. [ABSTRACT FROM AUTHOR]

Published
2023
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164. Lactobacillus paracaseiN1115 attenuates obesity in high‐fat diet‐induced obese mice.

Author

Sun, Yanan, Chen, Shanbin, Ren, Fazheng, and Li, Yixuan

Subjects
FATTY acid synthases, LDL cholesterol, TOLL-like receptors, LACTOBACILLUS, OBESITY, WEIGHT gain, INTERLEUKIN-1 receptors
Abstract

Disruption of the microbial structure of intestinal bacteria due to a high‐fat diet (HFD) is closely associated with metabolic disorders, such as obesity and type 2 diabetes. Probiotics are known to modulate the gut microbiota; therefore, we demonstrated the capability of Lactobacillus paracasei N1115 (LC‐N1115) to attenuate obesity. Four‐week‐old male C57BL/6J mice were fed a HFD for 12 weeks to induce obesity and were then randomized to supplemented placebo or LC‐N1115 treatment group for another 12 weeks. LC‐N1115 treatment reduced weight gain and liver fat accumulation as well as triglyceride, total cholesterol, and low‐density lipoprotein cholesterol levels. The administration of LC‐N1115 suppressed the expression of fatty acid synthase, interleukin‐1 β, and toll‐like receptor 4. Notably, the operational taxonomic units that negatively and positively correlated with the obesity phenotypes were enriched and reduced, respectively, in the LC‐N1115 treatment group. These results indicate that LC‐N1115 attenuates obesity by modulating the gut microbiota and the expression of lipid synthesis and proinflammatory cytokine genes. [ABSTRACT FROM AUTHOR]

Published
2023
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167. Plasma Vitamin E and the Risk of First Stroke in Hypertensive Patients: A Nested Case-Control Study

Author

Song, Yun, primary, Li, Jingyi, additional, Liu, Lishun, additional, Xu, Richard, additional, Zhou, Ziyi, additional, Xu, Benjamin, additional, Lin, Tengfei, additional, Chen, Ping, additional, Li, Huan, additional, Li, Youbao, additional, Liu, Chengzhang, additional, Huang, Xiao, additional, Wang, Binyan, additional, Zhang, Yan, additional, Li, Jianping, additional, Huo, Yong, additional, Ren, Fazheng, additional, Xu, Xiping, additional, Zhang, Hao, additional, and Qin, Xianhui, additional

Published
2021
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196. Lactobacillus paracasei M11‐4 isolated from fermented rice demonstrates good antioxidant properties in vitro and in vivo.

Author

Yang, Jianjun, Dong, Chenyang, Ren, Fazheng, Xie, Yuanhong, Liu, Hui, Zhang, Hongxing, and Jin, Junhua

Subjects
GALACTOSE, PROBIOTICS, LACTOBACILLUS, GUT microbiome, ANTIOXIDANTS, RICE, CELL culture
Abstract

BACKGROUND Probiotics are defined as microorganisms that can exert health benefits for the host. Among the recognized probiotics, Lactobacillus paracasei are one of the most frequently used probiotics in humans. The L. paracasei strain M11‐4, isolated from fermented rice (which could ferment soymilk within a short curd time) and fermented soymilk presented high viability, acceptable flavor, and antioxidant activity, which revealed that the strain maybe have a potential antioxidant value. Therefore, it is necessary to further explore the antioxidant activity of L. paracasei strain M11‐4. RESULTS: The radical scavenging activities, lipid peroxidation inhibition, and reducing power of L. paracasei M11‐4 were the highest in the fermentation culture without cells, whereas the activities of other antioxidant enzymes of L. paracasei M11‐4 were high in the cell‐free extract and bacterial suspension. Moreover, L. paracasei M11‐4 exerted its antioxidant effect by upregulating the gene expression of its antioxidant enzymes – the thioredoxin and glutathione systems – when hydrogen peroxide existed. Supplementation of rats with L. paracasei M11‐4 effectively alleviated d‐galactose‐induced oxidative damage in the liver and serum and prevented d‐galactose‐induced changes to intestinal microbiota. Supplementation with L. paracasei M11‐4 also reduced the elevated expression of thioredoxin and glutathione system genes induced by d‐galactose. CONCLUSION: L. paracasei M11‐4 has good antioxidant properties both in vitro and in vivo, and its antioxidant mechanism was studied at the molecular level. © 2021 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Published
2022
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200. SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD

Author

Chang Liu, Zhang Ming, Mingjuan Deng, Ge Shaoyang, Fang Qu, Hao Zhang, Liang Zhao, Chaodong Wu, Ren Fazheng, Huiyuan Guo, and Chen Long

Subjects
0301 basic medicine, medicine.medical_specialty, Sodium Acetate, Endocrinology, Diabetes and Metabolism, Aspartate transaminase, 030209 endocrinology & metabolism, Butyrate, Acetates, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, Non-alcoholic Fatty Liver Disease, Internal medicine, medicine, Animals, Aspartate Aminotransferases, chemistry.chemical_classification, Inflammation, biology, Macrophages, Short-chain fatty acid, Sodium butyrate, Alanine Transaminase, medicine.disease, Fatty Acids, Volatile, Fatty Liver, Mice, Inbred C57BL, Butyrates, 030104 developmental biology, chemistry, Sodium propionate, Propionate, biology.protein, Hepatocytes, Butyric Acid, Steatosis, Propionates
Abstract

This study aimed to assess the effects of three major SCFAs (acetate, propionate, and butyrate) on NASH phenotype in mice. C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet and treated with sodium acetate, sodium propionate, or sodium butyrate during the 6-week feeding period. SCFA treatment significantly reduced serum levels of alanine aminotransferase and aspartate transaminase, the numbers of lipid droplets, and the levels of triglycerides and cholesterols in livers of the mice compared with control treatment. SCFAs also reduced MCD-induced hepatic aggregation of macrophages and proinflammatory responses. Among the three SCFAs, sodium acetate (NaA) revealed the best efficacy at alleviating MCD-induced hepatic steatosis and inflammation. Additionally, NaA increased AMP-activated protein kinase activation in the liver and induced the expression of fatty acid oxidation gene in both the liver and cultured hepatocytes. In vitro, NaA decreased MCD-mimicking media-induced proinflammatory responses in macrophages to a greater extent than in hepatocytes. These results indicated that NaA alleviates steatosis in a manner involving AMPK activation. Also, NaA alleviation of hepatic inflammation appears to be due to, in large part, suppression of macrophage proinflammatory activation. SCFAs may represent as a novel and viable approach for alleviating NASH.

Published
2020

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