151. Allergen-Specific Immunotherapy Increases Plasma Gelsolin Levels
- Author
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Sabina Janciauskiene, Rembert Koczulla, Lars-Olaf Cardell, Ulla Westin, Beata Olejnicka, and Tobias Welte
- Subjects
Adult ,Male ,Allergen immunotherapy ,Allergy ,Fas Ligand Protein ,medicine.medical_treatment ,Apoptosis ,Poaceae ,Immunoglobulin E ,Fas ligand ,Young Adult ,Humans ,Immunology and Allergy ,Medicine ,CCL17 ,Betula ,Gelsolin ,Sweden ,Tissue Inhibitor of Metalloproteinase-1 ,biology ,business.industry ,Rhinitis, Allergic, Seasonal ,General Medicine ,Immunotherapy ,Allergens ,Antigens, Plant ,medicine.disease ,Otorhinolaryngology ,Desensitization, Immunologic ,Immunology ,biology.protein ,Pollen ,Female ,Chemokine CCL17 ,Antibody ,business ,Biomarkers - Abstract
Background It has been observed that patients with allergic asthma/rhinitis have increased apoptosis of peripheral blood cells. This study was designed to explore the idea that the markers of apoptosis may help predict the response of allergen immunotherapy. Methods The Allergy Department of University Hospital, Malmö, Sweden, recruited a total of 58 young adults (Results In patients receiving immunotherapy plasma gelsolin levels were higher relative to those without immunotherapy (the median level was 23.97 μg/mL [range, 18–35.8 μg/mL] versus 21.2 μg/mL [range, 13.9–29.8 μg/mL]; p = 0.012) and were similar to those of healthy controls (24.7 μg/mL [range, 17.4–35.3 μg/mL]). Plasma levels of sFas, Fas-L, CCL17, and TIMP-1 did not differ between study groups. Only in controls did the plasma gelsolin levels inversely correlate to the levels of soluble Fas. Conclusion Allergen-specific immunotherapy increases plasma levels of gelsolin, an antioxidant and antiapoptotic protein. more...
- Published
- 2014
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