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152. Supplementary Figure S6 from The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Author

Wang, Yifan, primary, Bernhardy, Andrea J., primary, Cruz, Cristina, primary, Krais, John J., primary, Nacson, Joseph, primary, Nicolas, Emmanuelle, primary, Peri, Suraj, primary, van der Gulden, Hanneke, primary, van der Heijden, Ingrid, primary, O'Brien, Shane W., primary, Zhang, Yong, primary, Harrell, Maribel I., primary, Johnson, Shawn F., primary, Candido Dos Reis, Francisco J., primary, Pharoah, Paul D. P., primary, Karlan, Beth, primary, Gourley, Charlie, primary, Lambrechts, Diether, primary, Chenevix-Trench, Georgia, primary, Olsson, Håkan, primary, Benitez, Javier J., primary, Greene, Mark H., primary, Gore, Martin, primary, Nussbaum, Robert, primary, Sadetzki, Siegal, primary, Gayther, Simon A., primary, Kjaer, Susanne K., primary, D'Andrea, Alan D., primary, Shapiro, Geoffrey I., primary, Wiest, David L., primary, Connolly, Denise C., primary, Daly, Mary B., primary, Swisher, Elizabeth M., primary, Bouwman, Peter, primary, Jonkers, Jos, primary, Balmaña, Judith, primary, Serra, Violeta, primary, and Johnson, Neil, primary

Published
2023
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153. Data from The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Author

Wang, Yifan, primary, Bernhardy, Andrea J., primary, Cruz, Cristina, primary, Krais, John J., primary, Nacson, Joseph, primary, Nicolas, Emmanuelle, primary, Peri, Suraj, primary, van der Gulden, Hanneke, primary, van der Heijden, Ingrid, primary, O'Brien, Shane W., primary, Zhang, Yong, primary, Harrell, Maribel I., primary, Johnson, Shawn F., primary, Candido Dos Reis, Francisco J., primary, Pharoah, Paul D. P., primary, Karlan, Beth, primary, Gourley, Charlie, primary, Lambrechts, Diether, primary, Chenevix-Trench, Georgia, primary, Olsson, Håkan, primary, Benitez, Javier J., primary, Greene, Mark H., primary, Gore, Martin, primary, Nussbaum, Robert, primary, Sadetzki, Siegal, primary, Gayther, Simon A., primary, Kjaer, Susanne K., primary, D'Andrea, Alan D., primary, Shapiro, Geoffrey I., primary, Wiest, David L., primary, Connolly, Denise C., primary, Daly, Mary B., primary, Swisher, Elizabeth M., primary, Bouwman, Peter, primary, Jonkers, Jos, primary, Balmaña, Judith, primary, Serra, Violeta, primary, and Johnson, Neil, primary

Published
2023
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154. Supplementary Tables S1-S4 from The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Author

Wang, Yifan, primary, Bernhardy, Andrea J., primary, Cruz, Cristina, primary, Krais, John J., primary, Nacson, Joseph, primary, Nicolas, Emmanuelle, primary, Peri, Suraj, primary, van der Gulden, Hanneke, primary, van der Heijden, Ingrid, primary, O'Brien, Shane W., primary, Zhang, Yong, primary, Harrell, Maribel I., primary, Johnson, Shawn F., primary, Candido Dos Reis, Francisco J., primary, Pharoah, Paul D. P., primary, Karlan, Beth, primary, Gourley, Charlie, primary, Lambrechts, Diether, primary, Chenevix-Trench, Georgia, primary, Olsson, Håkan, primary, Benitez, Javier J., primary, Greene, Mark H., primary, Gore, Martin, primary, Nussbaum, Robert, primary, Sadetzki, Siegal, primary, Gayther, Simon A., primary, Kjaer, Susanne K., primary, D'Andrea, Alan D., primary, Shapiro, Geoffrey I., primary, Wiest, David L., primary, Connolly, Denise C., primary, Daly, Mary B., primary, Swisher, Elizabeth M., primary, Bouwman, Peter, primary, Jonkers, Jos, primary, Balmaña, Judith, primary, Serra, Violeta, primary, and Johnson, Neil, primary

Published
2023
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155. Supplementary Methods and References from The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Author

Wang, Yifan, primary, Bernhardy, Andrea J., primary, Cruz, Cristina, primary, Krais, John J., primary, Nacson, Joseph, primary, Nicolas, Emmanuelle, primary, Peri, Suraj, primary, van der Gulden, Hanneke, primary, van der Heijden, Ingrid, primary, O'Brien, Shane W., primary, Zhang, Yong, primary, Harrell, Maribel I., primary, Johnson, Shawn F., primary, Candido Dos Reis, Francisco J., primary, Pharoah, Paul D. P., primary, Karlan, Beth, primary, Gourley, Charlie, primary, Lambrechts, Diether, primary, Chenevix-Trench, Georgia, primary, Olsson, Håkan, primary, Benitez, Javier J., primary, Greene, Mark H., primary, Gore, Martin, primary, Nussbaum, Robert, primary, Sadetzki, Siegal, primary, Gayther, Simon A., primary, Kjaer, Susanne K., primary, D'Andrea, Alan D., primary, Shapiro, Geoffrey I., primary, Wiest, David L., primary, Connolly, Denise C., primary, Daly, Mary B., primary, Swisher, Elizabeth M., primary, Bouwman, Peter, primary, Jonkers, Jos, primary, Balmaña, Judith, primary, Serra, Violeta, primary, and Johnson, Neil, primary

Published
2023
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156. Supplementary Figure Legends from The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Author

Wang, Yifan, primary, Bernhardy, Andrea J., primary, Cruz, Cristina, primary, Krais, John J., primary, Nacson, Joseph, primary, Nicolas, Emmanuelle, primary, Peri, Suraj, primary, van der Gulden, Hanneke, primary, van der Heijden, Ingrid, primary, O'Brien, Shane W., primary, Zhang, Yong, primary, Harrell, Maribel I., primary, Johnson, Shawn F., primary, Candido Dos Reis, Francisco J., primary, Pharoah, Paul D. P., primary, Karlan, Beth, primary, Gourley, Charlie, primary, Lambrechts, Diether, primary, Chenevix-Trench, Georgia, primary, Olsson, Håkan, primary, Benitez, Javier J., primary, Greene, Mark H., primary, Gore, Martin, primary, Nussbaum, Robert, primary, Sadetzki, Siegal, primary, Gayther, Simon A., primary, Kjaer, Susanne K., primary, D'Andrea, Alan D., primary, Shapiro, Geoffrey I., primary, Wiest, David L., primary, Connolly, Denise C., primary, Daly, Mary B., primary, Swisher, Elizabeth M., primary, Bouwman, Peter, primary, Jonkers, Jos, primary, Balmaña, Judith, primary, Serra, Violeta, primary, and Johnson, Neil, primary

Published
2023
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162. Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer

Author

Candido dos Reis, Francisco J., Lynn, Stuart, Ali, H. Raza, Eccles, Diana, Hanby, Andrew, Provenzano, Elena, Caldas, Carlos, Howat, William J., McDuffus, Leigh-Anne, Liu, Bin, Daley, Frances, Coulson, Penny, Vyas, Rupesh J., Harris, Leslie M., Owens, Joanna M., Carton, Amy F.M., McQuillan, Janette P., Paterson, Andy M., Hirji, Zohra, Christie, Sarah K., Holmes, Amber R., Schmidt, Marjanka K., Garcia-Closas, Montserrat, Easton, Douglas F., Bolla, Manjeet K., Wang, Qin, Benitez, Javier, Milne, Roger L., Mannermaa, Arto, Couch, Fergus, Devilee, Peter, Tollenaar, Robert A.E.M., Seynaeve, Caroline, Cox, Angela, Cross, Simon S., Blows, Fiona M., Sanders, Joyce, de Groot, Renate, Figueroa, Jonine, Sherman, Mark, Hooning, Maartje, Brenner, Hermann, Holleczek, Bernd, Stegmaier, Christa, Lintott, Chris, and Pharoah, Paul D.P.

Published
2015
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163. CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

Author

Kang, Eun-Young, Weir, Ashley, Meagher, Nicola S, Farrington, Kyo, Nelson, Gregg S, Ghatage, Prafull, Lee, Cheng-Han, Riggan, Marjorie J, Bolithon, Adelyn, Popovic, Gordana, Leung, Betty, Tang, Katrina, Lambie, Neil, Millstein, Joshua, Alsop, Jennifer, Anglesio, Michael S, Ataseven, Beyhan, Barlow, Ellen, Beckmann, Matthias W, Berger, Jessica, Bisinotto, Christiani, Bösmüller, Hans, Boros, Jessica, Brand, Alison H, Brooks-Wilson, Angela, Brucker, Sara Y, Carney, Michael E, Casablanca, Yovanni, Cazorla-Jiménez, Alicia, Cohen, Paul A, Conrads, Thomas P, Cook, Linda S, Coulson, Penny, Courtney-Brooks, Madeleine, Cramer, Daniel W, Crowe, Philip, Cunningham, Julie M, Cybulski, Cezary, Darcy, Kathleen M, El-Bahrawy, Mona A, Elishaev, Esther, Erber, Ramona, Farrell, Rhonda, Fereday, Sian, Fischer, Anna, García, María J, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Gilks, C Blake, AOCS Group, Grube, Marcel, Harnett, Paul R, Harrington, Shariska Petersen, Harter, Philipp, Hartmann, Arndt, Hecht, Jonathan L, Heikaus, Sebastian, Hein, Alexander, Heitz, Florian, Hendley, Joy, Hernandez, Brenda Y, Polo, Susanna Hernando, Heublein, Sabine, Hirasawa, Akira, Høgdall, Estrid, Høgdall, Claus K, Horlings, Hugo M, Huntsman, David G, Huzarski, Tomasz, Jewell, Andrea, Jimenez-Linan, Mercedes, Jones, Michael E, Kaufmann, Scott H, Kennedy, Catherine J, Khabele, Dineo, Kommoss, Felix KF, Kruitwagen, Roy FPM, Lambrechts, Diether, Le, Nhu D, Lener, Marcin, Lester, Jenny, Leung, Yee, Linder, Anna, Loverix, Liselore, Lubiński, Jan, Madan, Rashna, Maxwell, G Larry, Modugno, Francesmary, Neuhausen, Susan L, Olawaiye, Alexander, Olbrecht, Siel, Orsulic, Sandra, Palacios, José, Pearce, Celeste Leigh, Pike, Malcolm C, Quinn, Carmel M, Mohan, Ganendra Raj, Rodríguez-Antona, Cristina, Ruebner, Matthias, Ryan, Andy, Salfinger, Stuart G, Sasamoto, Naoko, Schildkraut, Joellen M, Schoemaker, Minouk J, Shah, Mitul, Sharma, Raghwa, Shvetsov, Yurii B, Singh, Naveena, Sonke, Gabe S, Steele, Linda, Stewart, Colin, Sundfeldt, Karin, Swerdlow, Anthony J, Talhouk, Aline, Tan, Adeline, Taylor, Sarah E, Terry, Kathryn L, Tołoczko, Aleksandra, Traficante, Nadia, Van De Vijver, Koen K, Van Der Aa, Maaike A, Van Gorp, Toon, Van Nieuwenhuysen, Els, Van-Wagensveld, Lilian, Vergote, Ignace, Vierkant, Robert A, Wang, Chen, Wilkens, Lynne R, Winham, Stacey J, Wu, Anna H, Benitez, Javier, Berchuck, Andrew, Candido Dos Reis, Francisco J, DeFazio, Anna, Fasching, Peter A, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Karlan, Beth Y, Kommoss, Stefan, Menon, Usha, Sinn, Hans-Peter, Staebler, Annette, Brenton, James D, Bowtell, David D, Pharoah, Paul DP, Ramus, Susan J, Köbel, Martin, Meagher, Nicola S [0000-0001-9134-2118], Lee, Cheng-Han [0000-0003-2094-1222], Fereday, Sian [0000-0002-8559-8579], Kennedy, Catherine J [0000-0002-4465-5784], Sasamoto, Naoko [0000-0002-4526-2181], Schildkraut, Joellen M [0000-0002-0990-9339], Talhouk, Aline [0000-0001-7760-410X], Vergote, Ignace [0000-0002-7589-8981], Köbel, Martin [0000-0002-6615-2037], and Apollo - University of Cambridge Repository

Subjects
Ovarian Neoplasms, Oncogene Proteins, Carcinoma, Cystadenocarcinoma, Serous, ovarian cancer, high-grade serous carcinoma, Cyclin E, Humans, Female, prognosis, RNA, Messenger, CCNE1 amplification, cyclin E1 expression, Transcription Factors
Abstract

BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC. METHODS: Within the Ovarian Tumor Tissue Analysis consortium, amplification status and protein level in 3029 HGSC cases and mRNA expression in 2419 samples were investigated. RESULTS: High-level amplification (>8 copies by chromogenic in situ hybridization) was found in 8.6% of HGSC and overexpression (>60% with at least 5% demonstrating strong intensity by immunohistochemistry) was found in 22.4%. CCNE1 high-level amplification and overexpression both were linked to shorter overall survival in multivariate survival analysis adjusted for age and stage, with hazard stratification by study (hazard ratio [HR], 1.26; 95% CI, 1.08-1.47, p = .034, and HR, 1.18; 95% CI, 1.05-1.32, p = .015, respectively). This was also true for cases with combined high-level amplification/overexpression (HR, 1.26; 95% CI, 1.09-1.47, p = .033). CCNE1 mRNA expression was not associated with overall survival (HR, 1.00 per 1-SD increase; 95% CI, 0.94-1.06; p = .58). CCNE1 high-level amplification is mutually exclusive with the presence of germline BRCA1/2 pathogenic variants and shows an inverse association to RB1 loss. CONCLUSION: This study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC.

Published
2023
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164. Avaliação do impacto da pandemia COVID-19 e do uso de telemedicina na eficácia e segurança do tratamento do câncer ginecológico e de mama em um hospital universitário

Author

Reis, Francisco Jose Candido Dos

Abstract

Introdução: Algumas das consequências da pandemia do COVID-19 foram o distanciamento social, a diminuição da procura de consultas médicas presenciais e as recomendações de uso da telemedicina o máximo possível por muitas sociedades médicas. Um dos possíveis prejuízos da teleconsulta seria a menor detecção de recorrências em pacientes tratadas de câncer de mama, principalmente relacionadas à impossibilidade de se realizar um exame físico completo. Por outro lado, a dificuldade de acesso ao serviço de saúde, poderia comprometer a detecção de recorrência e, consequentemente, o prognóstico. Desta forma, o presente estudo se propôs avaliar o padrão de recorrência e os desfechos em pacientes já tratadas de câncer de mama no período pré-pandemia e durante a pandemia. Objetivo: Avaliar o percentual de recorrências, locais e sistêmicas, do câncer de mama detectadas através do exame físico. Ainda, avaliar se houve alteração no padrão de recorrência do câncer de mama nas pacientes diagnosticadas durante a pandemia. Métodos: Trata-se de uma coorte histórica composta por mulheres que foram diagnosticadas com câncer de mama, entre janeiro de 2011 e março de 2022, e apresentaram recorrência pós-tratamento. Realizamos a coleta de dados clínicos dos prontuários das pacientes e foi analisado o cenário pré-pandêmico do diagnóstico de recorrência, data igual ou superior a 23 de março de 2020, avaliando o percentual de pacientes diagnosticadas exclusivamente por exame físico em consulta de rotina, bem como o padrão de recorrência durante o período de pandemia e comparação com o período anterior. Em um total de 2.891 pacientes que tiveram atendimento no serviço entre 2011 a 2021, com o diagnóstico inicial a partir de 2011, 187 pacientes foram diagnosticadas com recorrência de câncer de mama e preencheram os critérios de inclusão para análise, sendo que 64 delas apresentaram recorrência exclusivamente local. Resultados: Identificamos uma diferença significativa relacionada a mortalidade das pacientes com recorrência. A análise de Kaplan-Meier mostrou diferença significativa entre esses grupos (log rank p = 0,013), sendo a mediana do grupo pandêmico próxima de 9 meses e a mediana do outro grupo, 22 meses. O Hazard Ratio (HR) foi de 0,56. Na amostra do estudo, 116 pacientes (62%) tiveram recorrências sistêmicas e 71 (38%) tiveram recidivas locais. Entre as recidivas locais, houve 28% dos óbitos (35 pacientes), e nas recidivas a distância, 72% (91 pacientes). Dentre os diagnósticos, 11 casos (6%) do total de recidivas foram detectados exclusivamente pelo exame físico, 105 casos (56%) pelos sintomas e 50 (27%) pelos exames radiológicos. Conclusão: As pacientes que tiveram detecção de recorrência durante a pandemia, tiveram redução significativa na sobrevida em comparação à população pré-pandemia. Além disso, a detecção de recorrência local exclusivamente através do exame físico foi a forma menos frequente de detecção em comparação às demais formas de detecção de recorrências. Durante a pandemia, houve uma tendência de um número menor de detecção de recorrências locais, porém não estatisticamente significativa. A detecção de sintomas relacionados à recorrência por teleconsulta ocorreu em um caso e a detecção de progressão da doença pós-recorrência em outro, o que revela ser uma ferramenta facilitadora no processo de agendamento e continuidade dos exames, tanto para diagnósticos quanto para tratamentos. Os fatores envolvidos na pandemia impactaram negativamente na sobrevida das pacientes com recorrência do câncer de mama, podendo estar relacionados à dificuldade ou receio de acesso ao serviço, recusa por tratamento ou necessidade de adaptações do tratamento.

Published
2023
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169. Clinicopathological characteristics and recurrence risk in patients with ductal carcinoma in situ of the breast

Author

Bruno, Marcelo Hueb Cecilio Naves, primary, Souza, Vitor Hugo de, additional, Orlandini, Leonardo Fleury, additional, Carrara, Helio Humberto Angotti, additional, Reis, Francisco José Candido dos, additional, Andrade, Jurandyr Moreira de, additional, Bosquesi, Priscila Longhin, additional, and Tiezzi, Daniel Guimarães, additional

Published
2023
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170. Endometrial carcinosarcoma

Author

Bogani, Giorgio, primary, Ray-Coquard, Isabelle, additional, Concin, Nicole, additional, Ngoi, Natalie Yan Li, additional, Morice, Philippe, additional, Caruso, Giuseppe, additional, Enomoto, Takayuki, additional, Takehara, Kazuhiro, additional, Denys, Hannelore, additional, Lorusso, Domenica, additional, Coleman, Robert, additional, Vaughan, Michelle M, additional, Takano, Masashi, additional, Provencher, Diane Michele, additional, Sagae, Satoru, additional, Wimberger, Pauline, additional, Póka, Robert, additional, Segev, Yakir, additional, Kim, Se Ik, additional, Kim, Jae-Weon, additional, Candido dos Reis, Francisco Jose, additional, Ramirez, Pedro T, additional, Mariani, Andrea, additional, Leitao, Mario, additional, Makker, Vicky, additional, Abu-Rustum, Nadeem R, additional, Vergote, Ignace, additional, Zannoni, Gianfranco, additional, Tan, David, additional, McCormack, Mary, additional, Paolini, Biagio, additional, Bini, Marta, additional, Raspagliesi, Francesco, additional, Benedetti Panici, Pierluigi, additional, Di Donato, Violante, additional, Muzii, Ludovico, additional, Colombo, Nicoletta, additional, Pignata, Sandro, additional, Scambia, Giovanni, additional, and Monk, Bradley J, additional

Published
2022
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181. Cold, heat, or double thermal shock in tambaqui (Colossoma macropomum): Triploid induction, fertilization rate, growth, and hematological variables.

Author

Pereira, Gilmar Amaro, Copatti, Carlos Eduardo, Figueiredo, Rozzanno Antônio Cavalcanti Reis de, Reis, Francisco José de Souza, Costa, Lucas, Souza, Gustavo, and Melo, José

Subjects
THERMAL shock, TAMBAQUI, SHOCK therapy, HEATING control
Abstract

This study assessed the effectiveness of triploidy in tambaqui (Colossoma macropomum) and compared the fertilization, survival, growth performance, and hematological parameters of diploid and triploid fish. After artificial reproduction, freshly fertilized eggs were subjected to cold, heat or double thermal shock or were not exposed to the thermal shock (control group). Double thermal shock presented fertilization rate significantly lower than other treatments. Larvae submitted to cold thermal shock had a higher weight than the control and heat thermal shock treatments. The final weight of juveniles exposed to cold thermal shock was significantly higher than the other treatments with triploid induction. There was no significant difference for survival and hematological variables. The cold thermal shock produced more triploid individuals (33.33%) than the heat and double thermal shock (both 11.11%). The cold thermal shock was the most effective technique for obtaining triploid fish and it contributed to increasing the weight of tambaqui larvae. [ABSTRACT FROM AUTHOR]

Published
2023
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190. 10-year opportunistic mammographic screening scenario in Brazil and its impact on breast cancer early detection: a nationwide population-based study

Author

Cuoghi, Isabela Campeti, primary, da Silva Soares, Mariana Furlani, additional, dos Santos, Gustavo Motta Cabello, additional, dos-Reis, Francisco José Candido, additional, Poli-Neto, Omero Benedicto, additional, de Andrade, Jurandyr Moreira, additional, Bosquesi, Priscila Longhin, additional, Orlandini, Leonardo Fleury, additional, and Tiezzi, Daniel Guimarães, additional

Published
2022
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192. 2022-RA-402-ESGO Proteomic analysis of exosomes secreted during mesenchymal-epithelial transition for potential diagnosis of mesenchymal subtype of high grade ovarian serous carcinoma

Author

Ferreira, Germano Aguiar, primary, Thomé, Carolina Hassibe, additional, Izumi, Clarice, additional, Grassi, Mariana Lopes, additional, Lanfredi, Guilherme Paupério, additional, Smolka, Marcus, additional, Faça, Vitor Marcel, additional, and Candido dos Reis, Francisco José, additional

Published
2022
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196. Un análisis visual de la cobertura inmunobiológica, su infraestructura y efectos en el estado de Bahía

Author

Nascimento, Gabriel de Almeida, Reis, Francisco Rodrigo Moreni dos, Novais, Renato, Sousa , Daniel Xavier de, and Almeida, Antonio Gabriel Souza

Subjects
Vacina, Vacunas, Doenças epidemiológicas, Immunization, Enfermedades epidemiológicas, COVID-19, Câmaras de conservação, Cámaras de conservación, Epidemiological diseases, Inmunización, Vaccine, Imunização, Conservation chambers
Abstract

The article illustrates the performance of the National Immunization Program (PNI) in Bahia, the vaccination coverage in relation to the number of inhabitants, as well as the correlation with investment in health, through the extraction and analysis of data from DATASUS, IBGE and FNS. It appears that although the investment in health in the analyzed period has been relevant, the logistics and storage of vaccines is still very precarious, given the lack of infrastructure, such as storage chambers for vaccines needed in the municipalities of Bahia. Some pathologies such as whooping cough, poliomyelitis and hepatitis, in the face of vaccination coverage, are treated individually and graphically illustrated, in order to demonstrate weaknesses in the performance of the PNI and how the population's adherence to movements contrary to Brazilian vaccination campaigns, influence and bring serious systemic concerns to the medical and scientific community. The visual analysis of this article graphically demonstrates some of the known outbreaks of diseases, as well as the history of vaccine coverage of immunobiologicals and intends to elucidate a method that can help in future decision making. El artículo ilustra el desempeño del Programa Nacional de Inmunización (PNI) en Bahía, la cobertura de vacunación en relación al número de habitantes, así como la correlación con la inversión en salud, a través de la extracción y análisis de datos de DATASUS, IBGE y FNS . Parece que aunque la inversión en salud en el período analizado haya sido relevante, la logística y almacenamiento de vacunas aún es muy precaria, dada la falta de infraestructura, como cámaras de almacenamiento de vacunas necesarias en los municipios de Bahia. Algunas patologías como la tos ferina, la poliomielitis y la hepatitis, frente a las coberturas de vacunación, son tratadas de forma individual e ilustradas gráficamente, con el fin de demostrar debilidades en el desempeño del PNI y cómo influye la adhesión de la población a movimientos contrarios a las campañas de vacunación brasileñas. y traer serias preocupaciones sistémicas a la comunidad médica y científica. El análisis visual de este artículo demuestra gráficamente algunos de los brotes de enfermedades conocidos, así como la historia de la cobertura vacunal de los inmunobiológicos y pretende dilucidar un método que pueda ayudar en la toma de decisiones futuras. O artigo ilustra a performance do Programa Nacional de Imunização (PNI) na Bahia, a cobertura da vacinação em relação à quantidade de habitantes, assim como a correlação com o investimento em saúde, através da extração e análise dos dados do DATASUS, IBGE e FNS. Verifica-se que embora o investimento em saúde no período analisado tenha sido relevante, a logística e armazenagem de vacinas ainda é muito precária, haja vista a falta de infraestrutura, tal qual câmaras de conservação de vacinas necessárias nos municípios baianos. Algumas patologias como coqueluche, poliomielite e hepatite, frente a cobertura vacinal, são tratadas individualmente e ilustradas de forma gráfica, afim de demonstrar fragilidades na performance do PNI e de como a aderência da população a respeito de movimentos contrários as campanhas de vacinação brasileira, influenciam e trazem sérias preocupações sistêmicas à comunidade médica e científica. As análises visuais deste artigo demonstram graficamente alguns dos conhecidos surtos de doenças, bem como o histórico de cobertura vacinal dos imunobiológicos e pretende elucidar um método que possa auxiliar em futuras tomadas de decisão.

Published
2022

197. Instalación de implantes siguiendo el flujo digital: reporte de un caso clínico

Author

Lima, Ricardo Seixas de Paiva, Lima, Gustavo Seixas de Paiva, Sendyk, Wilson Roberto, Reis, Francisco Carlos dos Santos, Massuda, Carlos Kiyosh Moreira, and Marão, Heloisa Fonseca

Subjects
Implante dental, Cirugía Guiada por Imágenes, Implante dentário, Image-Guided Surgery, Bone graft, Injerto óseo, Cirurgia Guiada por Imagem, Dental implant, Enxerto Ósseo
Abstract

Digital dentistry allowed the dental surgeon to perform dental procedures, in a different way, in the different specialties. In implantology, we can highlight guided surgery, which is performed after virtual planning, where the oral scanning with the patient's tomography is planned, using software. In this way, a surgical guide can be made using a 3D printer. The speed and precision of implant installation are the main advantages of this procedure, in addition to a more comfortable postoperative period for the patient, when the technique is performed without flaps (flapless). Therefore, this work aims to demonstrate to professionals in the area, the technique of guided surgery for dental implants, using virtual planning. The procedure was performed in a 66-year-old patient, in the maxillary premolar region, through digital planning, and an implant was installed using the SIN guided implant system. It was concluded that the guided surgery technique is a favorable technique, which provided greater speed, precision and faster recovery of the patient. La odontología digital permitió al cirujano dentista realizar procedimientos odontológicos, de manera diferente, en las distintas especialidades. En implantología podemos destacar la cirugía guiada, que se realiza previa planificación virtual, donde se planifica el escaneado oral con la tomografía del paciente, mediante un software. De esta forma, se puede fabricar una guía quirúrgica en una impresora 3D. La rapidez y precisión en la instalación de los implantes son las principales ventajas de este procedimiento, además de un postoperatorio más cómodo para el paciente, cuando la técnica se realiza sin colgajos (flapless). Por lo tanto, este trabajo tiene como objetivo demostrar a los profesionales del área, la técnica de cirugía guiada para implantes dentales, utilizando la planificación virtual. El procedimiento se realizó en un paciente de 66 años, en la región de premolares maxilares, mediante planificación digital, y se colocó un implante mediante el sistema de implante guiado SIN. Se concluyó que la técnica de cirugía guiada es una técnica favorable, que brindó mayor rapidez, precisión y una recuperación más rápida del paciente. A odontologia digital proporcionou ao cirurgião dentista realizar procedimentos odontológicos, de uma maneira diferente, nas diversas especialidades. Na implantologia podemos destacar a cirurgia guiada, que é realizada após o planejamento virtual, onde é planificado o escaneamento oral com a tomografia do paciente, utilizando um software. Desta maneira pode ser confeccionado, em uma impressora 3D, um guia cirúrgico. A rapidez e a precisão da instalação do implante, são as principais vantagens deste procedimento, além de um pós operatório mais confortável para o paciente, quando a técnica é realizada sem retalhos (flapless). Portanto, este trabalho tem como objetivo demonstrar aos profissionais da área, a técnica da cirurgia guiada para implantes dentários, com a utilização do planejamento virtual. O procedimento foi realizado em um paciente com 66 anos, na região do pré-molar superior, através do planejamento digital, sendo instalado um implante utilizando o sistema de implante guiado da SIN. Foi concluído que a técnica de cirurgia guiada é uma técnica favorável, que proporcionou uma maior rapidez, precisão e recuperação mais rápida do paciente.

Published
2022

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