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923 results on '"Reiner, Alex"'

151. DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Author: Matías-García, Pamela R., Ward-Caviness, Cavin K., Raffield, Laura M., Gao, Xu, Zhang, Yan, Wilson, Rory, Gào, Xīn, Nano, Jana, Bostom, Andrew, Colicino, Elena, Correa, Adolfo, Coull, Brent, Eaton, Charles, Hou, Lifang, Just, Allan C., Kunze, Sonja, Lange, Leslie, Lange, Ethan, Lin, Xihong, Liu, Simin, Nwanaji-Enwerem, Jamaji C., Reiner, Alex, Shen, Jincheng, Schöttker, Ben, Vokonas, Pantel, Zheng, Yinan, Young, Bessie, Schwartz, Joel, Horvath, Steve, Lu, Ake, Whitsel, Eric A., Koenig, Wolfgang, Adamski, Jerzy, Winkelmann, Juliane, Brenner, Hermann, Baccarelli, Andrea A., Gieger, Christian, Peters, Annette, Franceschini, Nora, and Waldenberger, Melanie
Subjects: ddc
Published: 2020

152. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Author: Holmes, Michael V, Dale, Caroline E, Zuccolo, Luisa, Silverwood, Richard J, Guo, Yiran, Ye, Zheng, Prieto-Merino, David, Dehghan, Abbas, Trompet, Stella, Wong, Andrew, Cavadino, Alana, Drogan, Dagmar, Padmanabhan, Sandosh, Li, Shanshan, Yesupriya, Ajay, Leusink, Maarten, Sundstrom, Johan, Hubacek, Jaroslav A, Pikhart, Hynek, Swerdlow, Daniel I, Panayiotou, Andrie G, Borinskaya, Svetlana A, Finan, Chris, Shah, Sonia, Kuchenbaecker, Karoline B, Shah, Tina, Engmann, Jorgen, Folkersen, Lasse, Eriksson, Per, Ricceri, Fulvio, Melander, Olle, Sacerdote, Carlotta, Gamble, Dale M, Rayaprolu, Sruti, Ross, Owen A, McLachlan, Stela, Vikhireva, Olga, Sluijs, Ivonne, Scott, Robert A, Adamkova, Vera, Flicker, Leon, Bockxmeer, Frank M van, Power, Christine, Marques-Vidal, Pedro, Meade, Tom, Marmot, Michael G, Ferro, Jose M, Paulos-Pinheiro, Sofia, Humphries, Steve E, Talmud, Philippa J, Leach, Irene Mateo, Verweij, Niek, Linneberg, Allan, Skaaby, Tea, Doevendans, Pieter A, Cramer, Maarten J, van der Harst, Pim, Klungel, Olaf H, Dowling, Nicole F, Dominiczak, Anna F, Kumari, Meena, Nicolaides, Andrew N, Weikert, Cornelia, Boeing, Heiner, Ebrahim, Shah, Gaunt, Tom R, Price, Jackie F, Lannfelt, Lars, Peasey, Anne, Kubinova, Ruzena, Pajak, Andrzej, Malyutina, Sofia, Voevoda, Mikhail I, Tamosiunas, Abdonas, Maitland-van der Zee, Anke H, Norman, Paul E, Hankey, Graeme J, Bergmann, Manuela M, Hofman, Albert, Franco, Oscar H, Cooper, Jackie, Palmen, Jutta, Spiering, Wilko, de Jong, Pim A, Kuh, Diana, Hardy, Rebecca, Uitterlinden, Andre G, Ikram, Arfan M, Ford, Ian, Hyppönen, Elina, Almeida, Osvaldo P, Wareham, Nicholas J, Khaw, Kay-Tee, Hamsten, Anders, Husemoen, Lise Lotte N, Tjønneland, Anne, Tolstrup, Janne S, Rimm, Eric, Beulens, Joline W J, Verschuren, Monique MW, Onland-Moret, Charlotte N, Hofker, Marten H, Wannamethee, Goya S, Whincup, Peter H, Morris, Richard, Vicente, Astrid M, Watkins, Hugh, Farrall, Martin, Jukema, Wouter J, Meschia, James, Cupples, Adrienne L, Sharp, Stephen J, Fornage, Myriam, Kooperberg, Charles, LaCroix, Andrea Z, Dai, James Y, Lanktree, Matthew B, Siscovick, David S, Jorgenson, Eric, Spring, Bonnie, Coresh, Josef, Li, Yun R, Buxbaum, Sarah G, Schreiner, Pamela J, Ellison, Curtis R, Tsai, Michael Y, Patel, Sanjay R, Redline, Susan, Johnson, Andrew D, Hoogeveen, Ron C, Hakonarson, Hakon, Rotter, Jerome I, Boerwinkle, Eric, de Bakker, Paul I W, Kivimaki, Mika, Asselbergs, Folkert W, Sattar, Naveed, Lawlor, Debbie A, Whittaker, John, Davey Smith, George, Mukamal, Kenneth, Psaty, Bruce M, Wilson, James G, Lange, Leslie A, Hamidovic, Ajna, Hingorani, Aroon D, Nordestgaard, Børge G, Bobak, Martin, Leon, David A, Langenberg, Claudia, Palmer, Tom M, Reiner, Alex P, Keating, Brendan J, Dudbridge, Frank, and Casas, Juan P
Published: 2014
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153. Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

Author: Yoneyama, Sachiko, Guo, Yiran, Lanktree, Matthew B., Barnes, Michael R., Elbers, Clara C., Karczewski, Konrad J, Padmanabhan, Sandosh, Bauer, Florianne, Baumert, Jens, Beitelshees, Amber, Berenson, Gerald S., Boer, Jolanda M.A., Burke, Gregory, Cade, Brian, Chen, Wei, Cooper-Dehoff, Rhonda M., Gaunt, Tom R., Gieger, Christian, Gong, Yan, Gorski, Mathias, Heard-Costa, Nancy, Johnson, Toby, Lamonte, Michael J., Mcdonough, Caitrin, Monda, Keri L., Onland-Moret, Charlotte N., Nelson, Christopher P., OʼConnell, Jeffrey R., Ordovas, Jose, Peter, Inga, Peters, Annette, Shaffer, Jonathan, Shen, Haiqinq, Smith, Erin, Speilotes, Liz, Thomas, Fridtjof, Thorand, Barbara, Verschuren, Monique W. M., Anand, Sonia S., Dominiczak, Anna, Davidson, Karina W., Hegele, Robert A., Heid, Iris, Hofker, Marten H., Huggins, Gordon S., Illig, Thomas, Johnson, Julie A., Kirkland, Susan, König, Wolfgang, Langaee, Taimour Y., Mccaffery, Jeanne, Melander, Olle, Mitchell, Braxton D., Munroe, Patricia, Murray, Sarah S., Papanicolaou, George, Redline, Susan, Reilly, Muredach, Samani, Nilesh J., Schork, Nicholas J., Van Der Schouw, Yvonne T., Shimbo, Daichi, Shuldiner, Alan R., Tobin, Martin D., Wijmenga, Cisca, Yusuf, Salim, Hakonarson, Hakon, Lange, Leslie A., Demerath, Ellen W, Fox, Caroline S., North, Kari E, Reiner, Alex P., Keating, Brendan, and Taylor, Kira C.
Published: 2014
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154. Imputation of coding variants in African Americans: better performance using data from the exome sequencing project

Author: Duan, Qing, Liu, Eric Yi, Auer, Paul L., Zhang, Guosheng, Lange, Ethan M., Jun, Goo, Bizon, Chris, Jiao, Shuo, Buyske, Steven, Franceschini, Nora, Carlson, Chris S., Hsu, Li, Reiner, Alex P., Peters, Ulrike, Haessler, Jeffrey, Curtis, Keith, Wassel, Christina L., Robinson, Jennifer G., Martin, Lisa W., Haiman, Christopher A., Le Marchand, Loic, Matise, Tara C., Hindorff, Lucia A., Crawford, Dana C., Assimes, Themistocles L., Kang, Hyun Min, Heiss, Gerardo, Jackson, Rebecca D., Kooperberg, Charles, Wilson, James G., Abecasis, Gonçalo R., North, Kari E., Nickerson, Deborah A., Lange, Leslie A., and Li, Yun
Published: 2013
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155. SMIM1absence is associated with reduced energy expenditure and excess weight

Author: Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Erikstrup, Christian, Rieneck, Klaus, Dziegiel, Morten H., Ullum, Henrik, Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia
Abstract: Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic architecture; however, single genetic variants with large effect size are etiological in a minority of cases. These variants allowed the discovery of novel genes and biology relevant to weight regulation and ultimately led to the development of novel specific treatments.
Published: 2024
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156. IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study

Author: Walston, Jeremy D., Fallin, M. Daniele, Cushman, Mary, Lange, Leslie, Psaty, Bruce, Jenny, Nancy, Browner, Warren, Tracy, Russell, Durda, Peter, and Reiner, Alex
Published: 2007
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157. Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Author: Pulit, Sara L., Weng, Lu-Chen, McArdle, Patrick F, Trinquart, Ludovic, Choi, Seung Hoan, Mitchell, Braxton D., Rosand, Jonathan, de Bakker, Paul I W, Benjamin, Emelia J, Ellinor, Patrick T, Kittner, Steven J, Lubitz, Steven A, Anderson, Christopher D, Christophersen, Ingrid E., Rienstra, Michiel, Roselli, Carolina, Yin, Xiaoyan, Geelhoed, Bastiaan, Barnard, John, Lin, Honghuang, Arking, Dan E., Smith, Albert V., Albert, Christine M., Chaffin, Mark, Tucker, Nathan R., Li, Molong, Klarin, Derek, Bihlmeyer, Nathan A, Low, Siew-Kee, Weeke, Peter E., Müller-Nurasyid, Martina, Smith, J. Gustav, Brody, Jennifer A., Niemeijer, Maartje N., Dörr, Marcus, Trompet, Stella, Huffman, Jennifer, Gustafsson, Stefan, Schurmann, Claudia, Kleber, Marcus E., Lyytikäinen, Leo-Pekka, Seppälä, Ilkka, Malik, Rainer, Horimoto, Andrea R. V. R., Perez, Marco, Sinisalo, Juha, Aeschbacher, Stefanie, Thériault, Sébastien, Yao, Jie, Radmanesh, Farid, Weiss, Stefan, Teumer, Alexander, Clauss, Sebastian, Deo, Rajat, Rader, Daniel J., Shah, Svati, Siland, Joylene E., Kubo, Michiaki, Smith, Jonathan D., Van Wagoner, David R., Bis, Joshua C., Perz, Siegfried, Psaty, Bruce M., Ridker, Paul M., Magnani, Jared W., Harris, Tamara B., Launer, Lenore J., Shoemaker, M. Benjamin, Padmanabhan, Sandosh, Haessler, Jeffrey, Bartz, Traci M., Waldenberger, Melanie, Lichtner, Peter, Arendt, Marina, Krieger, Jose E., Kähönen, Mika, Risch, Lorenz, Mansur, Alfredo J., Peters, Annette, Smith, Blair H., Lind, Lars, Scott, Stuart A., Lu, Yingchang, Bottinger, Erwin B., Hernesniemi, Jussi, Lindgren, Cecilia M., Wong, Jorge A, Huang, Jie, Eskola, Markku, Morris, Andrew P., Ford, Ian, Reiner, Alex P., Delgado, Graciela, Chen, Lin Y., Chen, Yii-Der Ida, Sandhu, Roopinder K., Li, Man, Boerwinkle, Eric, Eisele, Lewin, Lannfelt, Lars, Rost, Natalia, Orho-Melander, arju, Hamsten, Anders, Heeringa, Jan, Denny, Joshua C., Kriebel, Jennifer, Darbar, Dawood, Newton-Cheh, Christopher, Shaffer, Christian, Macfarlane, Peter W., Heilmann, Stefanie, Almgren, Peter, Huang, Paul L., Sotoodehnia, Nona, Soliman, Elsayed Z., Uitterlinden, Andre G., Hofman, Albert, Franco, Oscar H., Völker, Uwe, Jöckel, Karl-Heinz, Sinner, Moritz F., Lin, Henry J., Guo, Xiuqing, Dichgans, Martin, Ingelsson, Erik, Kooperberg, Charles, Melander, Olle, Loos, Ruth J. F., Laurikka, Jari, Conen, David, Harst, Pim van der, Lokki, Marja-Liisa, Kathiresan, Sekar, Pereira, Alexandre, Jukema, J. Wouter, Hayward, Caroline, Rotter, Jerome I., März, Winfried, Lehtimäki, Terho, Stricker, Bruno H., Chung, Mina K., Felix, Stephan B., Gudnason, Vilmundur, Alonso, Alvaro, Roden, Dan M., Sun, Albert, Anderson, Christopher D., Kääb, Stefan, Hopewell, Jemma C., Debette, Stephanie, Chauhan, Ganesh, Yang, Qiong, Worrall, Bradford B., Paré, Guillaume, Kamatani, Yoichiro, Hagemeijer, Yanick P., Verweij, Niek, Taylor, Kent D., Campbell, Archie, Magnusson, Patrik K., Porteous, David, Hocking, Lynne J., Vlachopoulou, Efthymia, Pedersen, Nancy L., Nikus, Kjell, Chasman, Daniel I., Heckbert, Susan R., Benjamin, Emelia J., Tanaka, Toshihiro, Lunetta, Kathryn L., Lubitz, Steven A., Ellinor, Patrick T., Smoller, Sylvia, Sorkin, John, Wang, Xingwu, Selim, Magdy, Pikula, Aleksandra, Wolf, Philip, Seshadri, Sudha, Bakker, Paul de, Chasman, Daniel, Rexrode, Kathryn, Chen, Ida, Rotter, Jerome, Luke, May, Sale, Michelle, Lee, Tsong-Hai, Chang, Ku-Chou, Elkind, Mitchell, Goldstein, Larry, James, Michael Luke, Breteler, Monique, O’Donnell, Chris, Leys, Didier, Carty, Cara, Kidwell, Chelsea, Olesen, Jes, Sharma, Pankaj, Rich, Stephen, Tatlisumak, Turgot, Happola, Olli, Bijlenga, Philippe, Soriano, Carolina, Giralt, Eva, Roquer, Jaume, Jimenez-Conde, Jordi, Cotlarcius, Ioana, Hardy, John, Korostynski, Michal, Boncoraglio, Giorgio, Ballabio, Elena, Parati, Eugenio, Mateusz, Adamski, Urbanik, Andrzej, Dziedzic, Tomasz, Jagiella, Jeremiasz, Gasowski, Jerzy, Wnuk, Marcin, Olszanecki, Rafael, Pera, Joanna, Slowik, Agnieszka, Juchniewicz, Karol Jozef, Levi, Christopher, Nyquist, Paul, Cendes, Iscia, Cabral, Norberto, Franca, Paulo, Goncalves, Anderson, Keller, Lina, Crisby, Milita, Kostulas, Konstantinos, Lemmens, Robin, Ahmadi, Kourosh, Opherk, Christian, Duering, Marco, Gonik, Mariya, Staals, Julie, Burri, Philippe, Sadr-Nabavi, Ariane, Romero, Javier, Biffi, Alessandro, Anderson, Chris, Falcone, Guido, Brouwers, Bart, Du, Rose, Kourkoulis, Christina, Battey, Thomas, Lubitz, Steven, Mueller-Myhsok, Bertram, Meschia, James, Brott, Thomas, Pare, Guillaume, Pichler, Alexander, Enzinger, Christian, Schmidt, Helena, Schmidt, Reinhold, Seiler, Stephan, Blanton, Susan, Yamada, Yoshiji, Bersano, Anna, Rundek, Tatjana, Sacco, Ralph, Chan, Yu-Feng Yvonne, Gschwendtner, Andreas, Deng, Zhen, Barr, Taura, Gwinn, Katrina, Corriveau, Roderick, Singleton, Andrew, Waddy, Salina, Launer, Lenore, Chen, Christopher, Le, Kim En, Lee, Wei Ling, Tan, Eng King, Olugbodi, Akintomi, Rothwell, Peter, Schilling, Sabrina, Mok, Vincent, Lebedeva, Elena, Jern, Christina, Jood, Katarina, Olsson, Sandra, Kim, Helen, Lee, Chaeyoung, Kilarski, Laura, Markus, Hugh, Peycke, Jennifer, Bevan, Steve, Sheu, Wayne, Chiou, Hung Yi, Chern, Joseph, Giraldo, Elias, Taqi, Muhammad, Jain, Vivek, Lam, Olivia, Howard, George, Woo, Daniel, Kittner, Steven, Mitchell, Braxton, Cole, John, O’Connell, Jeff, Milewicz, Dianna, Illoh, Kachikwu, Worrall, Bradford, Stine, Colin, Karaszewski, Bartosz, Werring, David, Sofat, Reecha, Smalley, June, Lindgren, Arne, Hansen, Bjorn, Norrving, Bo, Smith, Gustav, Martin, Juan Jose, Thijs, Vincent, Klijn, Karin, van’t Hof, Femke, Algra, Ale, Macleod, Mary, Perry, Rodney, Arnett, Donna, Pezzini, Alessandro, Padovani, Alessandro, Cramer, Steve, Fisher, Mark, Saleheen, Danish, Broderick, Joseph, Kissela, Brett, Doney, Alex, Cathie, Sudlow, Rannikmae, Kristiina, Silliman, Scott, McDonough, Caitrin, Walters, Matthew, Pedersen, Annie, Nakagawa, Kazuma, Chang, Christy, Dobbins, Mark, McArdle, Patrick, Chang, Yu-Ching, Brown, Robert, Brown, Devin, Holliday, Elizabeth, Kalaria, Raj, Maguire, Jane, John, Attia, Farrall, Martin, Giese, Anne-Katrin, Fornage, Myriam, Majersik, Jennifer, Cushman, Mary, Keene, Keith, Bennett, Siiri, Tirschwell, David, Psaty, Bruce, Reiner, Alex, Longstreth, Will, Spence, David, Montaner, Joan, Fernandez-Cadenas, Israel, Langefeld, Carl, Bushnell, Cheryl, Heitsch, Laura, Lee, Jin-Moo, Sheth, Kevin, Cardiovascular Centre (CVC), Department of Medicine, Clinicum, Transplantation Laboratory, Medicum, Neurologian yksikkö, Department of Neurosciences, University of Helsinki, Doctoral Programme in Clinical Research, HUS Neurocenter, Epidemiology, Internal Medicine, Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, and MUMC+: MA Med Staf Spec Neurologie (9)
Subjects: Medizin, 030204 cardiovascular system & hematology, VARIANTS, 3124 Neurology and psychiatry, 0302 clinical medicine, Epidemiology, Genotype, EPIDEMIOLOGY, Stroke, Genetics (clinical), 0303 health sciences, Aspirin, Atrial fibrillation, ASSOCIATION, 3. Good health, LIFETIME RISK, ISCHEMIC-STROKE, Cardiology, Biomarker (medicine), Medical genetics, BURDEN, Medical Genetics, Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Clinical Neurology, Single-nucleotide polymorphism, Article, 03 medical and health sciences, Internal medicine, Genetic predisposition, medicine, SNP, cardiovascular diseases, Genotyping, 030304 developmental biology, Genetic association, Medicinsk genetik, Science & Technology, business.industry, 3112 Neurosciences, Heritability, medicine.disease, PREVENTION, ASPIRIN, Neurology (clinical), Neurosciences & Neurology, business, 030217 neurology & neurosurgery, CAUSATIVE CLASSIFICATION
Abstract: ObjectiveWe sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk.MethodsWe evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.ResultsWe observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 × 10−4 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 × 10−48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, p = 0.004), but no other primary stroke subtypes (all p > 0.1).ConclusionsGenetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Published: 2018

158. Additional file 1 of Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

Author: Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Marielisa Graff, Weihong Tang, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, and Avery, Christy L.
Abstract: Additional file 1: Figure S1. Manhattan and Quantile-Quantile plots for individual RBC traits in the total study population. In Manhattan plots, previously reported loci (published index SNP reported p 500 kb from a previously reported significant variant for any RBC trait (blue) are both shown. Figure S2. Evidence of genetic associations shared across correlated RBC traits. X-axis: chromosome and position (top) and rsid (bottom) for each combined-phenotype lead SNP. Y-axis: trait-specific –log10(p-values), with increased intensity representing higher significance, for each combined-phenotype lead SNP. P-values scaled to a maximum –log10 value of 25 for improved interpretation. Figure S3. Locus-Zoom plots of the association between rs6573766 and RBCC in PAGE African Americans on an African American LD background (A), Hispanics/Latinos on a Hispanic/Latino LD background (B), and European Americans on a European LD background (C). Each point represents one SNP; x-axis: increasing position on chromosome 14 left to right; y-axis: -log10(p-value) of the association with MCH SNP correlation with the lead SNP (r2) is colored according to the legend in Figure S3A. Annotated Refseq genes proximal to the lead SNP are shown by position above the X axis. Figure S4. Locus-Zoom plot of the association between MCH (A) and MCV (B) and rs145548796 in the total MEGA study population. Each point represents one SNP; x-axis: increasing position on chromosome 6 left to right; y-axis: -log10(p-value) of the association with MCH SNP correlation with the lead SNP (r2) is colored according to the legend in Figure S4A. Annotated Refseq genes proximal to the lead SNP are shown by position above the X axis.
Published: 2020
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159. Esterified estrogens and conjugated equine estrogens and risk of venous thrombosis

Author: Smith, Nicholas L., Lemaitre, Rozen N., Lumley, Thomas, Larson, Eric B., Psaty, Bruce M., Rosendal, Frits R., Weiss, Noel S., Reiner, Alex P., and Heckbert, Susan R.
Subjects: Postmenopausal women -- Health aspects, Postmenopausal women -- Risk factors, Estrogen -- Risk factors, Estrogen -- Research, Thrombophlebitis -- Risk factors, Thrombophlebitis -- Research
Abstract: The risk of venous thrombosis among esterified estrogen users, conjugated equine estrogen users and nonusers are compared. The results revealed that conjugated equine estrogen associated with venous thrombotic risk needs to be replicated and may have implications for the choice of hormones in perimenopausal and postmenopausal women.
Published: 2004

160. Genetic variation associated with circulating monocyte count in the eMERGE Network

Author: Crosslin, David R., McDavid, Andrew, Weston, Noah, Zheng, Xiuwen, Hart, Eugene, de Andrade, Mariza, Kullo, Iftikhar J., McCarty, Catherine A., Doheny, Kimberly F., Pugh, Elizabeth, Kho, Abel, Hayes, M. Geoffrey, Ritchie, Marylyn D., Saip, Alexander, Crawford, Dana C., Crane, Paul K., Newton, Katherine, Carrell, David S., Gallego, Carlos J., Nalls, Michael A., Li, Rongling, Mirel, Daniel B., Crenshaw, Andrew, Couper, David J., Tanaka, Toshiko, van Rooij, Frank J.A., Chen, Ming-Huei, Smith, Albert V., Zakai, Neil A., Yango, Qiong, Garcia, Melissa, Liu, Yongmei, Lumley, Thomas, Folsom, Aaron R., Reiner, Alex P., Felix, Janine F., Dehghan, Abbas, Wilson, James G., Bis, Joshua C., Fox, Caroline S., Glazer, Nicole L., Cupples, L. Adrienne, Coresh, Josef, Eiriksdottir, Gudny, Gudnason, Vilmundur, Bandinelli, Stefania, Frayling, Timothy M., Chakravarti, Aravinda, van Duijn, Cornelia M., Melzer, David, Levy, Daniel, Boerwinkle, Eric, Singleton, Andrew B., Hernandez, Dena G., Longo, Dan L., Witteman, Jacqueline C.M., Psaty, Bruce M., Ferrucci, Luigi, Harris, Tamara B., OʼDonnell, Christopher J., Ganesh, Santhi K., Larson, Eric B., Carlson, Chris S., and Jarvik, Gail P.
Published: 2013
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161. Loci influencing blood pressure identified using a cardiovascular gene-centric array

Author: Ganesh, Santhi K., Tragante, Vinicius, Guo, Wei, Guo, Yiran, Lanktree, Matthew B., Smith, Erin N., Johnson, Toby, Castillo, Berta Almoguera, Barnard, John, Baumert, Jens, Chang, Yen-Pei Christy, Elbers, Clara C., Farrall, Martin, Fischer, Mary E., Franceschini, Nora, Gaunt, Tom R., Gho, Johannes M.I.H., Gieger, Christian, Gong, Yan, Isaacs, Aaron, Kleber, Marcus E., Leach, Irene Mateo, McDonough, Caitrin W., Meijs, Matthijs F.L., Mellander, Olle, Molony, Cliona M., Nolte, Ilja M., Padmanabhan, Sandosh, Price, Tom S., Rajagopalan, Ramakrishnan, Shaffer, Jonathan, Shah, Sonia, Shen, Haiqing, Soranzo, Nicole, van der Most, Peter J., Van Iperen, Erik P.A., Van Setten, Jessic A., Vonk, Judith M., Zhang, Li, Beitelshees, Amber L., Berenson, Gerald S., Bhatt, Deepak L., Boer, Jolanda M.A., Boerwinkle, Eric, Burkley, Ben, Burt, Amber, Chakravarti, Aravinda, Chen, Wei, Cooper-DeHoff, Rhonda M., Curtis, Sean P., Dreisbach, Albert, Duggan, David, Ehret, Georg B., Fabsitz, Richard R., Fornage, Myriam, Fox, Ervin, Furlong, Clement E., Gansevoort, Ron T., Hofker, Marten H., Hovingh, G. Kees, Kirkland, Susan A., Kottke-Marchant, Kandice, Kutlar, Abdullah, LaCroix, Andrea Z., Langaee, Taimour Y., Li, Yun R., Lin, Honghuang, Liu, Kiang, Maiwald, Steffi, Malik, Rainer, Murugesan, Gurunathan, Newton-Cheh, Christopher, OʼConnell, Jeffery R., Onland-Moret, N. Charlotte, Ouwehand, Willem H., Palmas, Walter, Penninx, Brenda W., Pepine, Carl J., Pettinger, Mary, Polak, Joseph F., Ramachandran, Vasan S., Ranchalis, Jane, Redline, Susan, Ridker, Paul M., Rose, Lynda M., Scharnag, Hubert, Schork, Nicholas J., Shimbo, Daichi, Shuldiner, Alan R., Srinivasan, Sathanur R., Stolk, Ronald P., Taylor, Herman A., Thorand, Barbara, Trip, Mieke D., van Duijn, Cornelia M., Verschuren, W. Monique, Wijmenga, Cisca, Winkelmann, Bernhard R., Wyatt, Sharon, Young, J. Hunter, Boehm, Bernhard O., Caulfield, Mark J., Chasman, Daniel I., Davidson, Karina W., Doevendans, Pieter A., FitzGerald, Garret A., Gums, John G., Hakonarson, Hakon, Hillege, Hans L., Illig, Thomas, Jarvik, Gail P., Johnson, Julie A., Kastelein, John J.P., Koenig, Wolfgang, März, Winfried, Mitchell, Braxton D., Murray, Sarah S., Oldehinkel, Albertine J., Rader, Daniel J., Reilly, Muredach P., Reiner, Alex P., Schadt, Eric E., Silverstein, Roy L., Snieder, Harold, Stanton, Alice V., Uitterlinden, André G., van der Harst, Pim, van der Schouw, Yvonne T., Samani, Nilesh J., Johnson, Andrew D., Munroe, Patricia B., de Bakker, Paul I.W., Zhu, Xiaofeng, Levy, Daniel, Keating, Brendan J., and Asselbergs, Folkert W.
Published: 2013
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162. Transforming growth factor beta-1 and incidence of heart failure in older adults: The Cardiovascular Health Study

Author: Glazer, Nicole L., Macy, Elizabeth M., Lumley, Thomas, Smith, Nicholas L., Reiner, Alex P., Psaty, Bruce M., King, George L., Tracy, Russell P., and Siscovick, David S.
Published: 2012
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163. Mendelian randomization analysis with survival outcomes

Author: Cho, Youngjoo, primary, Rau, Andrea, additional, Reiner, Alex, additional, and Auer, Paul L., additional
Published: 2020
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164. The Trans-Ancestral Genomic Architecture of Glycaemic Traits

Author: Chen, Ji, primary, Spracklen, Cassandra N., additional, Marenne, Gaëlle, additional, Varshney, Arushi, additional, Corbin, Laura J, additional, Luan, Jian’an, additional, Willems, Sara, additional, Wu, Ying, additional, Zhang, Xiaoshuai, additional, Horikoshi, Momoko, additional, Boutin, Thibaud S, additional, Mägi, Reedik, additional, Waage, Johannes, additional, Pitsilides, Achilleas, additional, Li-Gao, Ruifang, additional, Hang, Kei, additional, Yao, Jie, additional, Anasanti, Mila D, additional, Chu, Audrey Y, additional, Claringbould, Annique, additional, Heikkinen, Jani, additional, Hong, Jaeyoung, additional, Hottenga, Jouke-Jan, additional, Huo, Shaofeng, additional, Kaakinen, Marika A., additional, Louie, Tin, additional, März, Winfried, additional, Moreno-Macias, Hortensia, additional, Ndungu, Anne, additional, Nelson, Sarah C., additional, Nolte, Ilja M., additional, North, Kari, additional, Raulerson, Chelsea K., additional, Ray, Debashree, additional, Rohde, Rebecca, additional, Rybin, Denis, additional, Schurmann, Claudia, additional, Sim, Xueling, additional, Southam, Loz, additional, Stewart, Isobel, additional, Wang, Carol A., additional, Wang, Yujie, additional, Wu, Peitao, additional, Zhang, Weihua, additional, Ahluwalia, Tarunveer S., additional, Appel, Emil VR, additional, Bielak, Lawrence F., additional, Brody, Jennifer A., additional, Burtt, Noel P, additional, Cabrera, Claudia P, additional, Cade, Brian E, additional, Chai, Jin Fang, additional, Chai, Xiaoran, additional, Chang, Li-Ching, additional, Chen, Chien-Hsiun, additional, Chen, Brian H, additional, Chitrala, Kumaraswamy N, additional, Chiu, Yen-Feng, additional, de Haan, Hugoline G., additional, Delgado, Graciela E, additional, Demirkan, Ayse, additional, Duan, Qing, additional, Engmann, Jorgen, additional, Fatumo, Segun A, additional, Gayán, Javier, additional, Giulianini, Franco, additional, Gong, Jung Ho, additional, Gustafsson, Stefan, additional, Hai, Yang, additional, Hartwig, Fernando P, additional, He, Jing, additional, Heianza, Yoriko, additional, Huang, Tao, additional, Huerta-Chagoya, Alicia, additional, Hwang, Mi Yeong, additional, Jensen, Richard A., additional, Kawaguchi, Takahisa, additional, Kentistou, Katherine A, additional, Kim, Young Jin, additional, Kleber, Marcus E, additional, Kooner, Ishminder K, additional, Lai, Shuiqing, additional, Lange, Leslie A, additional, Langefeld, Carl D, additional, Lauzon, Marie, additional, Li, Man, additional, Ligthart, Symen, additional, Liu, Jun, additional, Loh, Marie, additional, Long, Jirong, additional, Lyssenko, Valeriya, additional, Mangino, Massimo, additional, Marzi, Carola, additional, Montasser, May E, additional, Nag, Abhishek, additional, Nakatochi, Masahiro, additional, Noce, Damia, additional, Noordam, Raymond, additional, Pistis, Giorgio, additional, Preuss, Michael, additional, Raffield, Laura, additional, Rasmussen-Torvik, Laura J., additional, Rich, Stephen S, additional, Robertson, Neil R, additional, Rueedi, Rico, additional, Ryan, Kathleen, additional, Sanna, Serena, additional, Saxena, Richa, additional, Schraut, Katharina E, additional, Sennblad, Bengt, additional, Setoh, Kazuya, additional, Smith, Albert V, additional, Southam, Lorraine, additional, Sparsø, Thomas, additional, Strawbridge, Rona J, additional, Takeuchi, Fumihiko, additional, Tan, Jingyi, additional, Trompet, Stella, additional, van den Akker, Erik, additional, Van der Most, Peter J, additional, Verweij, Niek, additional, Vogel, Mandy, additional, Wang, Heming, additional, Wang, Chaolong, additional, Wang, Nan, additional, Warren, Helen R, additional, Wen, Wanqing, additional, Wilsgaard, Tom, additional, Wong, Andrew, additional, Wood, Andrew R, additional, Xie, Tian, additional, Zafarmand, Mohammad Hadi, additional, Zhao, Jing-Hua, additional, Zhao, Wei, additional, Amin, Najaf, additional, Arzumanyan, Zorayr, additional, Astrup, Arne, additional, Bakker, Stephan JL, additional, Baldassarre, Damiano, additional, Beekman, Marian, additional, Bergman, Richard N, additional, Bertoni, Alain, additional, Blüher, Matthias, additional, Bonnycastle, Lori L., additional, Bornstein, Stefan R, additional, Bowden, Donald W, additional, Cai, Qiuyin, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chang, Yi Cheng, additional, de Geus, Eco J.C., additional, Dehghan, Abbas, additional, Du, Shufa, additional, Eiriksdottir, Gudny, additional, Farmaki, Aliki Eleni, additional, Frånberg, Mattias, additional, Fuchsberger, Christian, additional, Gao, Yutang, additional, Gjesing, Anette P, additional, Goel, Anuj, additional, Han, Sohee, additional, Hartman, Catharina A, additional, Herder, Christian, additional, Hicks, Andrew A., additional, Hsieh, Chang-Hsun, additional, Hsueh, Willa A., additional, Ichihara, Sahoko, additional, Igase, Michiya, additional, Ikram, M. Arfan, additional, Johnson, W. Craig, additional, Jørgensen, Marit E, additional, Joshi, Peter K, additional, Kalyani, Rita R, additional, Kandeel, Fouad R., additional, Katsuya, Tomohiro, additional, Khor, Chiea Chuen, additional, Kiess, Wieland, additional, Kolcic, Ivana, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Läll, Kristi, additional, Lam, Kelvin, additional, Lawlor, Deborah A, additional, Lee, Nanette R., additional, Lemaitre, Rozenn N., additional, Li, Honglan, additional, Study, Lifelines Cohort, additional, Lin, Shih-Yi, additional, Lindström, Jaana, additional, Linneberg, Allan, additional, Liu, Jianjun, additional, Lorenzo, Carlos, additional, Matsubara, Tatsuaki, additional, Matsuda, Fumihiko, additional, Mingrone, Geltrude, additional, Mooijaart, Simon, additional, Moon, Sanghoon, additional, Nabika, Toru, additional, Nadkarni, Girish N., additional, Nadler, Jerry L., additional, Nelis, Mari, additional, Neville, Matthew J, additional, Norris, Jill M, additional, Ohyagi, Yasumasa, additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Qi, Qibin, additional, Raven, Dennis, additional, Reilly, Dermot F, additional, Reiner, Alex, additional, Rivideneira, Fernando, additional, Roll, Kathryn, additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Sandow, Kevin, additional, Sattar, Naveed, additional, Schürmann, Annette, additional, Shi, Jinxiu, additional, Stringham, Heather M, additional, Taylor, Kent D., additional, Teslovich, Tanya M., additional, Thuesen, Betina, additional, Timmers, Paul RHJ, additional, Tremoli, Elena, additional, Tsai, Michael Y, additional, Uitterlinden, Andre, additional, van Dam, Rob M, additional, van Heemst, Diana, additional, van Hylckama Vlieg, Astrid, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Wang, Tao, additional, van Dijk, Ko Willems, additional, Xiang, Yongbing, additional, Zemunik, Tatijana, additional, Abecasis, Goncalo R, additional, Adair, Linda S., additional, Aguilar-Salinas, Carlos Alberto, additional, Alarcón-Riquelme, Marta E, additional, An, Ping, additional, Aviles-Santa, Larissa, additional, Becker, Diane M, additional, Beilin, Lawrence J, additional, Bergmann, Sven, additional, Bisgaard, Hans, additional, Black, Corri, additional, Boehnke, Michael, additional, Boerwinkle, Eric, additional, Böhm, Bernhard O, additional, Bønnelykke, Klaus, additional, Boomsma, D I., additional, Bottinger, Erwin P., additional, Buchanan, Thomas A, additional, Canouil, Mickaël, additional, Caulfield, Mark J, additional, Chambers, John C., additional, Chasman, Daniel I., additional, Chen, Yii-Der Ida, additional, Cheng, Ching-Yu, additional, Collins, Francis S., additional, Correa, Adolfo, additional, Cucca, Francesco, additional, de Silva, H. Janaka, additional, Dedoussis, George, additional, Elmståhl, Sölve, additional, Evans, Michele K., additional, Ferranni, Ele, additional, Ferruci, Luigi, additional, Florez, Jose C, additional, Franks, Paul, additional, Frayling, Timothy M, additional, Froguel, Philippe, additional, Gigante, Bruna, additional, Goodarzi, Mark O., additional, Gordon-Larsen, Penny, additional, Grallert, Harald, additional, Grarup, Niels, additional, Grimsgaard, Sameline, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Hamsten, Anders, additional, Hansen, Torben, additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Horta, Bernardo L, additional, Huang, Wei, additional, Ingelsson, Erik, additional, James, Pankow S, additional, Jonas, Jost B, additional, Jukema, J. Wouter, additional, Kaleebu, Pontiano, additional, Kaplan, Robert, additional, Kardia, Sharon L.R., additional, Kato, Norihiro, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kim, Bong-Jo, additional, Kivimaki, Mika, additional, Koistinen, Heikki A., additional, Kooner, Jaspal S., additional, Körner, Antje, additional, Kovacs, Peter, additional, Kuh, Diana, additional, Kumari, Meena, additional, Kutalik, Zoltan, additional, Laakso, Markku, additional, Lakka, Timo A., additional, Launer, Lenore J, additional, Leander, Karin, additional, Li, Huaixing, additional, Lin, Xu, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Simin, additional, Loos, Ruth J.F., additional, Magnusson, Patrik, additional, Mahajan, Anubha, additional, Metspalu, Andres, additional, Mook-Kanamori, Dennis O, additional, Mori, Trevor A, additional, Munroe, Patricia B, additional, Njølstad, Inger, additional, O’Connell, Jeffrey R, additional, Oldehinkel, Albertine J, additional, Ong, Ken K, additional, Padmanabhan, Sandosh, additional, Palmer, Colin N.A., additional, Palmer, Nicholette D, additional, Pedersen, Oluf, additional, Pennell, Craig E, additional, Porteous, David J, additional, Pramstaller, Peter P., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Qi, Lu, additional, Raffel, Leslie J., additional, Rauramaa, Rainer, additional, Redline, Susan, additional, Ridker, Paul M, additional, Rosendaal, Frits R., additional, Saaristo, Timo E., additional, Sandhu, Manjinder, additional, Saramies, Jouko, additional, Schneiderman, Neil, additional, Schwarz, Peter, additional, Scott, Laura J., additional, Selvin, Elizabeth, additional, Sever, Peter, additional, Shu, Xiao-ou, additional, Slagboom, P Eline, additional, Small, Kerrin S, additional, Smith, Blair H, additional, Snieder, Harold, additional, Sofer, Tamar, additional, Sørensen, Thorkild I.A., additional, Spector, Tim D, additional, Stanton, Alice, additional, Steves, Claire J, additional, Stumvoll, Michael, additional, Sun, Liang, additional, Tabara, Yasuharu, additional, Tai, E Shyong, additional, Timpson, Nicholas J, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Tusie, Teresa, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, van Duijn, Cornelia, additional, Vitart, Veronique, additional, Vollenweider, Peter, additional, Vrijkotte, Tanja GM, additional, Wagenknecht, Lynne E, additional, Walker, Mark, additional, Wang, Ya X, additional, Wareham, Nick J, additional, Watanabe, Richard M, additional, Watkins, Hugh, additional, Wei, Wen B, additional, Wickremasinghe, Ananda R, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wong, Tien-Yin, additional, Wu, Jer-Yuarn, additional, Xiang, Anny H, additional, Yanek, Lisa R, additional, Yengo, Loïc, additional, Yokota, Mitsuhiro, additional, Zeggini, Eleftheria, additional, Zheng, Wei, additional, Zonderman, Alan B, additional, Rotter, Jerome I, additional, Gloyn, Anna L, additional, McCarthy, Mark I., additional, Dupuis, Josée, additional, Meigs, James B, additional, Scott, Robert, additional, Prokopenko, Inga, additional, Leong, Aaron, additional, Liu, Ching-Ti, additional, Parker, Stephen CJ, additional, Mohlke, Karen L., additional, Langenberg, Claudia, additional, Wheeler, Eleanor, additional, Morris, Andrew P., additional, and Barroso, Inês, additional
Published: 2020
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165. A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Author: Stilp, Adrienne M., primary, Emery, Leslie S., additional, Broome, Jai G., additional, Buth, Erin J., additional, Khan, Alyna T., additional, Laurie, Cecelia A., additional, Wang, Fei Fei, additional, Wong, Quenna, additional, Chen, Dongquan, additional, D’Augustine, Catherine M., additional, Heard-Costa, Nancy L., additional, Hohensee, Chancellor R., additional, Johnson, William Craig, additional, Juarez, Lucia D., additional, Liu, Jingmin, additional, Mutalik, Karen M., additional, Raffield, Laura M., additional, Wiggins, Kerri L., additional, de Vries, Paul S., additional, Kelly, Tanika N., additional, Kooperberg, Charles, additional, Natarajan, Pradeep, additional, Peloso, Gina M., additional, Peyser, Patricia A., additional, Reiner, Alex P., additional, Arnett, Donna K., additional, Aslibekyan, Stella, additional, Barnes, Kathleen C., additional, Bielak, Lawrence F., additional, Bis, Joshua C., additional, Cade, Brian E., additional, Chen, Ming-Huei, additional, Correa, Adolfo, additional, Cupples, L. Adrienne, additional, de Andrade, Mariza, additional, Ellinor, Patrick T., additional, Fornage, Myriam, additional, Franceschini, Nora, additional, Gan, Weiniu, additional, Ganesh, Santhi K., additional, Graffelman, Jan, additional, Grove, Megan L., additional, Guo, Xiuqing, additional, Hawley, Nicola L., additional, Hsu, Wan-Ling, additional, Jackson, Rebecca D., additional, Jaquish, Cashell E., additional, Johnson, Andrew D., additional, Kardia, Sharon LR, additional, Kelly, Shannon, additional, Lee, Jiwon, additional, Mathias, Rasika A., additional, McGarvey, Stephen T., additional, Mitchell, Braxton D., additional, Montasser, May E., additional, Morrison, Alanna C., additional, North, Kari E., additional, Nouraie, Seyed Mehdi, additional, Oelsner, Elizabeth C., additional, Pankratz, Nathan, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Smith, Jennifer A., additional, Taylor, Kent D., additional, Vasan, Ramachandran S., additional, Weeks, Daniel E., additional, Weiss, Scott T., additional, Wilson, Carla G., additional, Yanek, Lisa R., additional, Psaty, Bruce M., additional, Heckbert, Susan R., additional, and Laurie, Cathy C., additional
Published: 2020
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166. Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans

Author: Leavitt, Colton, primary, Zakai, Neil A., additional, Auer, Paul, additional, Cushman, Mary, additional, Lange, Ethan M., additional, Levitan, Emily B., additional, Olson, Nels, additional, Thornton, Timothy A., additional, Tracy, Russell P., additional, Wilson, James G., additional, Lange, Leslie A., additional, Reiner, Alex P., additional, and Raffield, Laura M., additional
Published: 2020
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167. Soluble CD14, Ischemic Stroke, and Coronary Heart Disease Risk in a Prospective Study: The REGARDS Cohort

Author: Olson, Nels C., primary, Koh, Insu, additional, Reiner, Alex P., additional, Judd, Suzanne E., additional, Irvin, Marguerite R., additional, Howard, George, additional, Zakai, Neil A., additional, and Cushman, Mary, additional
Published: 2020
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168. Abstract P246: Dimensions of and Coping Responses to Perceived Discrimination and Leukocyte Telomere Length Among African Americans in The Jackson Heart Study

Author: Glover, LáShauntá M, primary, Cene, Crystal N, additional, Gebreab, Samson, additional, Williams, David R, additional, Wilson, James G, additional, Reiner, Alex, additional, North, Kari E, additional, and Sims, Mario, additional
Published: 2020
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169. Abstract P450: Radon is Associated With Clonal Hematopoiesis of Indeterminate Potential in the Women’s Health Initiative

Author: Anthony, Kurtis M, primary, Manson, Joann E, additional, Jaiswal, Siddhartha, additional, Natarajan, Pradeep, additional, Desai, Pinkal, additional, Hayden, Kathleen M, additional, Bick, Alexander G, additional, Carty, Cara L, additional, Collins, Jason M, additional, Love, Shelly-ann, additional, Stewart, James, additional, Schwartz, Gary, additional, Reiner, Alex, additional, and Whitsel, Eric A, additional
Published: 2020
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170. Abstract 25: Epigenome-Wide DNA Methylation Analysis Reveals Novel Hematologic Trait Associations for African Americans in The Jackson Heart Study

Author: Szeto, Mindy D, primary, Raffield, Laura M, additional, Nickerson, Deborah A, additional, Zakai, Neil A, additional, Klemm, Dwight J, additional, Taylor, Matthew R, additional, Yang, Ivana V, additional, Correa, Adolfo, additional, Reiner, Alex P, additional, Lange, Ethan M, additional, and Lange, Leslie A, additional
Published: 2020
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171. Abstract P451: Aircraft Noise Exposure As A Novel Risk Factor For Clonal Hematopoiesis Of Indeterminate Potential

Author: Collins, Jason M, primary, Reiner, Alex, additional, Manson, Joann E, additional, Bick, Alexander G, additional, Natarajan, Pradeep, additional, Hayden, Kathleen M, additional, Stewart, James, additional, Holliday, Katelyn, additional, Anthony, Kurtis, additional, Love, Shelly-ann, additional, Fox, Matthew, additional, Wellenius, Gregory A, additional, Peters, Junenette, additional, and Whitsel, Eric A, additional
Published: 2020
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172. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans

Author: Pendergrass, Sarah A., primary, Buyske, Steven, additional, Jeff, Janina M., additional, Frase, Alex, additional, Dudek, Scott, additional, Bradford, Yuki, additional, Ambite, Jose-Luis, additional, Avery, Christy L., additional, Buzkova, Petra, additional, Deelman, Ewa, additional, Fesinmeyer, Megan D., additional, Haiman, Christopher, additional, Heiss, Gerardo, additional, Hindorff, Lucia A., additional, Hsu, Chun-Nan, additional, Jackson, Rebecca D., additional, Lin, Yi, additional, Le Marchand, Loic, additional, Matise, Tara C., additional, Monroe, Kristine R., additional, Moreland, Larry, additional, North, Kari E., additional, Park, Sungshim L., additional, Reiner, Alex, additional, Wallace, Robert, additional, Wilkens, Lynne R., additional, Kooperberg, Charles, additional, Ritchie, Marylyn D., additional, and Crawford, Dana C., additional
Published: 2019
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173. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Author: Kachroo, Priyadarshini, primary, Hecker, Julian, additional, Chawes, Bo L., additional, Ahluwalia, Tarunveer S., additional, Cho, Michael H., additional, Qiao, Dandi, additional, Kelly, Rachel S., additional, Chu, Su H., additional, Virkud, Yamini V., additional, Huang, Mengna, additional, Barnes, Kathleen C., additional, Burchard, Esteban G., additional, Eng, Celeste, additional, Hu, Donglei, additional, Celedón, Juan C., additional, Daya, Michelle, additional, Levin, Albert M., additional, Gui, Hongsheng, additional, Williams, L. Keoki, additional, Forno, Erick, additional, Mak, Angel C.Y., additional, Avila, Lydiana, additional, Soto-Quiros, Manuel E., additional, Cloutier, Michelle M., additional, Acosta-Pérez, Edna, additional, Canino, Glorisa, additional, Bønnelykke, Klaus, additional, Bisgaard, Hans, additional, Raby, Benjamin A., additional, Lange, Christoph, additional, Weiss, Scott T., additional, Lasky-Su, Jessica A., additional, Abe, Namiko, additional, Abecasis, Goncalo, additional, Albert, Christine, additional, Palmer Allred, Nicholette (Nichole), additional, Almasy, Laura, additional, Alonso, Alvaro, additional, Ament, Seth, additional, Anderson, Peter, additional, Anugu, Pramod, additional, Applebaum-Bowden, Deborah, additional, Arking, Dan, additional, Arnett, Donna K., additional, Ashley-Koch, Allison, additional, Aslibekyan, Stella, additional, Assimes, Tim, additional, Auer, Paul, additional, Avramopoulos, Dimitrios, additional, Barnard, John, additional, Barnes, Kathleen, additional, Barr, R. Graham, additional, Barron-Casella, Emily, additional, Beaty, Terri, additional, Becker, Diane, additional, Becker, Lewis, additional, Beer, Rebecca, additional, Begum, Ferdouse, additional, Beitelshees, Amber, additional, Benjamin, Emelia, additional, Bezerra, Marcos, additional, Bielak, Larry, additional, Bis, Joshua, additional, Blackwell, Thomas, additional, Blangero, John, additional, Boerwinkle, Eric, additional, Borecki, Ingrid, additional, Bowler, Russell, additional, Brody, Jennifer, additional, Broeckel, Ulrich, additional, Broome, Jai, additional, Bunting, Karen, additional, Burchard, Esteban, additional, Cardwell, Jonathan, additional, Carty, Cara, additional, Casaburi, Richard, additional, Casella, James, additional, Chaffin, Mark, additional, Chang, Christy, additional, Chasman, Daniel, additional, Chavan, Sameer, additional, Chen, Bo-Juen, additional, Chen, Wei-Min, additional, Chen, Yii-Der Ida, additional, Choi, Seung Hoan, additional, Chuang, Lee-Ming, additional, Chung, Mina, additional, Cornell, Elaine, additional, Correa, Adolfo, additional, Crandall, Carolyn, additional, Crapo, James, additional, Cupples, L. Adrienne, additional, Curran, Joanne, additional, Curtis, Jeffrey, additional, Custer, Brian, additional, Damcott, Coleen, additional, Darbar, Dawood, additional, Das, Sayantan, additional, David, Sean, additional, Davis, Colleen, additional, de Andrade, Mariza, additional, DeBaun, Michael, additional, Deka, Ranjan, additional, DeMeo, Dawn, additional, Devine, Scott, additional, Do, Ron, additional, Duan, Qing, additional, Duggirala, Ravi, additional, Durda, Peter, additional, Dutcher, Susan, additional, Eaton, Charles, additional, Ekunwe, Lynette, additional, Ellinor, Patrick, additional, Emery, Leslie, additional, Farber, Charles, additional, Farnam, Leanna, additional, Fingerlin, Tasha, additional, Flickinger, Matthew, additional, Fornage, Myriam, additional, Franceschini, Nora, additional, Fu, Mao, additional, Fullerton, Stephanie M., additional, Fulton, Lucinda, additional, Gabriel, Stacey, additional, Gan, Weiniu, additional, Gao, Yan, additional, Gass, Margery, additional, Gelb, Bruce, additional, Geng, Xiaoqi (Priscilla), additional, Germer, Soren, additional, Gignoux, Chris, additional, Gladwin, Mark, additional, Glahn, David, additional, Gogarten, Stephanie, additional, Gong, Da-Wei, additional, Goring, Harald, additional, Gu, C. Charles, additional, Guan, Yue, additional, Guo, Xiuqing, additional, Haessler, Jeff, additional, Hall, Michael, additional, Harris, Daniel, additional, Hawley, Nicola, additional, He, Jiang, additional, Heavner, Ben, additional, Heckbert, Susan, additional, Hernandez, Ryan, additional, Herrington, David, additional, Hersh, Craig, additional, Hidalgo, Bertha, additional, Hixson, James, additional, Hokanson, John, additional, Holly, Kramer, additional, Hong, Elliott, additional, Hoth, Karin, additional, (Agnes) Hsiung, Chao, additional, Huston, Haley, additional, Hwu, Chii Min, additional, Irvin, Marguerite Ryan, additional, Jackson, Rebecca, additional, Jain, Deepti, additional, Jaquish, Cashell, additional, Jhun, Min A., additional, Johnsen, Jill, additional, Johnson, Andrew, additional, Johnson, Craig, additional, Johnston, Rich, additional, Jones, Kimberly, additional, Kachroo, Priyadarshini, additional, Kang, Hyun Min, additional, Kaplan, Robert, additional, Kardia, Sharon, additional, Kathiresan, Sekar, additional, Kaufman, Laura, additional, Kelly, Shannon, additional, Kenny, Eimear, additional, Kessler, Michael, additional, Khan, Alyna, additional, Kinney, Greg, additional, Konkle, Barbara, additional, Kooperberg, Charles, additional, Krauter, Stephanie, additional, Lange, Ethan, additional, Lange, Leslie, additional, Laurie, Cathy, additional, Laurie, Cecelia, additional, LeBoff, Meryl, additional, Lee, Seunggeun Shawn, additional, Lee, Wen-Jane, additional, LeFaive, Jonathon, additional, Levine, David, additional, Levy, Dan, additional, Lewis, Joshua, additional, Li, Yun, additional, Lin, Honghuang, additional, Lin, Keng Han, additional, Liu, Simin, additional, Liu, Yongmei, additional, Loos, Ruth, additional, Lubitz, Steven, additional, Lunetta, Kathryn, additional, Luo, James, additional, Mahaney, Michael, additional, Make, Barry, additional, Manichaikul, Ani, additional, Manson, JoAnn, additional, Margolin, Lauren, additional, Martin, Lisa, additional, Mathai, Susan, additional, Mathias, Rasika, additional, McArdle, Patrick, additional, McDonald, Merry-Lynn, additional, McFarland, Sean, additional, McGarvey, Stephen, additional, Mei, Hao, additional, Meyers, Deborah A., additional, Mikulla, Julie, additional, Min, Nancy, additional, Minear, Mollie, additional, Minster, Ryan L., additional, Mitchell, Braxton, additional, Montasser, May E., additional, Musani, Solomon, additional, Mwasongwe, Stanford, additional, Mychaleckyj, Josyf C., additional, Nadkarni, Girish, additional, Naik, Rakhi, additional, Natarajan, Pradeep, additional, Nekhai, Sergei, additional, Nickerson, Deborah, additional, North, Kari, additional, O'Connell, Jeff, additional, O'Connor, Tim, additional, Ochs-Balcom, Heather, additional, Pankow, James, additional, Papanicolaou, George, additional, Parker, Margaret, additional, Parsa, Afshin, additional, Penchev, Sara, additional, Peralta, Juan Manuel, additional, Perez, Marco, additional, Perry, James, additional, Peters, Ulrike, additional, Peyser, Patricia, additional, Phillips, Lawrence S., additional, Phillips, Sam, additional, Pollin, Toni, additional, Post, Wendy, additional, Becker, Julia Powers, additional, Boorgula, Meher Preethi, additional, Preuss, Michael, additional, Prokopenko, Dmitry, additional, Psaty, Bruce, additional, Qasba, Pankaj, additional, Qin, Zhaohui, additional, Rafaels, Nicholas, additional, Raffield, Laura, additional, Ramachandran, Vasan, additional, Rao, D.C., additional, Rasmussen-Torvik, Laura, additional, Ratan, Aakrosh, additional, Redline, Susan, additional, Reed, Robert, additional, Regan, Elizabeth, additional, Reiner, Alex, additional, Rice, Ken, additional, Rich, Stephen, additional, Roden, Dan, additional, Roselli, Carolina, additional, Rotter, Jerome, additional, Ruczinski, Ingo, additional, Russell, Pamela, additional, Ruuska, Sarah, additional, Ryan, Kathleen, additional, Sakornsakolpat, Phuwanat, additional, Salimi, Shabnam, additional, Salzberg, Steven, additional, Sandow, Kevin, additional, Sankaran, Vijay, additional, Scheller, Christopher, additional, Schmidt, Ellen, additional, Schwander, Karen, additional, Schwartz, David, additional, Sciurba, Frank, additional, Seidman, Christine, additional, Seidman, Jonathan, additional, Sheehan, Vivien, additional, Shetty, Amol, additional, Shetty, Aniket, additional, Sheu, Wayne Hui-Heng, additional, Shoemaker, M. Benjamin, additional, Silver, Brian, additional, Silverman, Edwin, additional, Smith, Jennifer, additional, Smith, Josh, additional, Smith, Nicholas, additional, Smith, Tanja, additional, Smoller, Sylvia, additional, Snively, Beverly, additional, Sofer, Tamar, additional, Sotoodehnia, Nona, additional, Stilp, Adrienne, additional, Streeten, Elizabeth, additional, Sung, Yun Ju, additional, Su-Lasky, Jessica, additional, Sylvia, Jody, additional, Szpiro, Adam, additional, Sztalryd, Carole, additional, Taliun, Daniel, additional, Tang, Hua, additional, Taub, Margaret, additional, Taylor, Kent, additional, Taylor, Simeon, additional, Telen, Marilyn, additional, Thornton, Timothy A., additional, Tinker, Lesley, additional, Tirschwell, David, additional, Tiwari, Hemant, additional, Tracy, Russell, additional, Tsai, Michael, additional, Vaidya, Dhananjay, additional, VandeHaar, Peter, additional, Vrieze, Scott, additional, Walker, Tarik, additional, Wallace, Robert, additional, Walts, Avram, additional, Wan, Emily, additional, Wang, Fei Fei, additional, Watson, Karol, additional, Weeks, Daniel E., additional, Weir, Bruce, additional, Weiss, Scott, additional, Weng, Lu-Chen, additional, Willer, Cristen, additional, Williams, Kayleen, additional, Wilson, Carla, additional, Wilson, James, additional, Wong, Quenna, additional, Xu, Huichun, additional, Yanek, Lisa, additional, Yang, Ivana, additional, Yang, Rongze, additional, Zaghloul, Norann, additional, Zekavat, Maryam, additional, Zhang, Yingze, additional, Zhao, Snow Xueyan, additional, Zhao, Wei, additional, Zheng, Xiuwen, additional, Zhi, Degui, additional, Zhou, Xiang, additional, Zody, Michael, additional, and Zoellner, Sebastian, additional
Published: 2019
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174. Genetic Ancestry in Lung-Function Predictions

Author: Kumar, Rajesh, Seibold, Max A., Aldrich, Melinda C., Williams, Keoki L., Reiner, Alex P., Colangelo, Laura, Galanter, Joshua, Gignoux, Christopher, Hu, Donglei, Sen, Saunak, Choudhry, Shweta, Peterson, Edward L., Rodriguez-Santana, Jose, Rodriguez-Cintron, William, Nalls, Michael A., Leak, Tennille S., OʼMeara, Ellen, Meibohm, Bernd, Kritchevsky, Stephen B., Li, Rongling, Harris, Tamara B., Nickerson, Deborah A., Fornage, Myriam, Enright, Paul, Ziv, Elad, Smith, Lewis J., Liu, Kiang, and Burchard, Esteban González
Published: 2010
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175. Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis

Author: Marini, Sandro, Crawford, Katherine, Morotti, Andrea, Lee, Myung J, Pezzini, Alessandro, Moomaw, Charles J, Flaherty, Matthew L, Montaner, Joan, Roquer, Jaume, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano-Tarraga, Carolina, Slowik, Agnieszka, Jagiella, Jeremiasz M, Pera, Joanna, Urbanik, Andrzej, Pichler, Alexander, Hansen, Bjorn M, McCauley, Jacob L, Tirschwell, David L, Selim, Magdy, Brown, Devin L, Silliman, Scott L, Worrall, Bradford B, Meschia, James F, Kidwell, Chelsea S, Testai, Fernando D, Kittner, Steven J, Schmidt, Helena, Enzinger, Christian, Deary, Lan J, Rannikmae, Kristiina, Samarasekera, Neshika, Salman, Rustam Al-Shahi, Sudlow, Catherine L, Klijn, Catharina JM, van Nieuwenhuizen, Koen M, Fernandez-Cadenas, Israel, Delgado, Pilar, Nonving, Bo, Lindgren, Ame, Goldstein, Joshua N, Viswanathan, Anand, Greenberg, Steven M, Falcone, Guido J, Biffi, Alessandro, Langefeld, Carl D, Woo, Daniel, Rosand, Jonathan, Anderson, Christopher D, Smoller, Sylvia, Sorkin, John, Wang, Xingwu, Pikula, Aleksandra, Wolf, Philip, Debette, Stephanie, Seshadri, Sudha, de Bakker, Paul, Chasman, Daniel, Rexrode, Kathryn, Chen, Ida, Rotter, Jerome, Luke, May, Sale, Michelle, Lee, Tsong-Hai, Chang, Ku-Chou, Elkind, Mitchell, Goldstein, Larry, James, Michael Luke, Breteler, Monique, O'Donnell, Chris, Leys, Didier, Carty, Cara, Kidwell, Chelsea, Olesen, Jes, Sharma, Pankaj, Rich, Stephen, Tatlisumak, Turgot, Happola, Olli, Bijlenga, Philippe, Soriano, Carolina, Giralt, Eva, Cotlarcius, Loana, Hardy, John, Korostynski, Michal, Boncoraglio, Giorgio, Ballabio, Elena, Parati, Eugenio, Mateusz, Adamski, Dziedzic, Tomasz, Jagiella, Jeremiasz, Gasowski, Jerzy, Wnuk, Marcin, Olszanecki, Rafaf, Juchniewicz, Karol Jozef, Levi, Christopher, Nyquist, Paul, Cendes, Iscia, Cabral, Norberto, Franca, Paulo, Goncalves, Anderson, Keller, Lina, Crisby, Milita, Kostulas, Konstantinos, Lennnnens, Robin, Ahmadi, Kourosh, Opherk, Christian, Duering, Marco, Dichgans, Martin, Malik, Rainer, Gonik, Mariya, Staals, Julie, Melander, Olle, Burri, Philippe, Sadr-Nabavi, Ariane, Romero, Javier, Anderson, Chris, Falcone, Guido, Brouwers, Bart, Rost, Natalia, Du, Rose, Kourkoulis, Christina, Battey, Thomas, Lubitz, Steven, Mueller-Myhsok, Bertram, Meschia, James, Brott, Thomas, Pare, Guillaume, Schmidt, Reinhold, Seiler, Stephan, Blanton, Susan, Yamada, Yoshiji, Bersano, Anna, Rundek, Tatiana, Sacco, Ralph, Chan, Yu-Feng Yvonne, Gschwendtner, Andreas, Deng, Zhen, Barr, Taura, Gwinn, Katrina, Corriveau, Roderick, Singleton, Andrew, Waddy, Salina, Launer, Lenore, Chen, Christopher, Le, Kim En, Lee, Wei Ling, Tan, Eng King, Olugbodi, Akintomi, Rothwell, Peter, Schilling, Sabrina, Mok, Vincent, Lebedeva, Elena, Jem, Christina, Jood, Katarina, Olsson, Sandra, Kim, Helen, Lee, Chaeyoung, Kilarski, Laura, Markus, Hugh, Peycke, Jennifer, Bevan, Steve, Sheu, Wayne, Chiou, Hung Yi, Chern, Joseph, Giraldo, Elias, Taqi, Muhammad, Jain, Vivek, Lam, Olivia, Howard, George, Kittner, Steven, Mitchell, Braxton, Cole, John, O'Connell, Jeff, Milewicz, Dianna, Illoh, Kachikwu, Worrall, Bradford, Stine, Colin, Karaszewski, Bartosz, Werring, David, Sofat, Reecha, Smalley, June, Lindgren, Arne, Hansen, Bjorn, Norrving, Bo, Smith, Gustav, Martin, Juan Jose, Thijs, Vincent, Klijn, Karin, van't Hof, Femke, Algra, Ale, Macleod, Mary, Perry, Rodney, Arnett, Donna, Padovani, Alessandro, Cramer, Steve, Fisher, Marl, Saleheen, Danish, Broderick, Joseph, Kissela, Brett, Doney, Alex, Sudlow, Cathie, Silliman, Scott, McDonough, Caitrin, Walters, Matthew, Pedersen, Annie, Nakagawa, Kazuma, Chang, Christy, Dobbins, Mark, McArdle, Patrick, Chang, Yu-Ching, Brown, Robert, Brown, Devin, Holliday, Elizabeth, Kalaria, Raj, Maguire, Jane, Hunter, John, Attia, John, Farrall, Martin, Giese, Anne-Katrin, Fomage, Myriam, Majersik, Jennifer, Cushman, Maly, Keene, Keith, Bennett, Siiri, Tirschwell, David, Psaty, Bruce, Reiner, Alex, Longstreth, Will, Spence, David, Langefeld, Carl, Bushnell, Cheryl, Heitsch, Laura, Lee, Jin-Moo, Sheth, Kevin, Consortium, Int Genetics, Neurologian yksikkö, Department of Neurosciences, Clinicum, Doctoral Programme in Clinical Research, HUS Neurocenter, RS: Carim - B05 Cerebral small vessel disease, RS: CARIM - R3.03 - Cerebral small vessel disease, and Epidemiology
Subjects: Male, Race ethnicity, Hemorràgia cerebral, 3124 Neurology and psychiatry, 0302 clinical medicine, Risk Factors, WHITES, BLACKS, 030212 general & internal medicine, Biological sciences, Original Investigation, ALZHEIMER-DISEASE, African Americans, Aged, 80 and over, GENETIC-VARIATION, Hispanic or Latino, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Medical research, University hospital, 3. Good health, ETHNICITY, ALLELE, Research centre, Hypertension, lipids (amino acids, peptides, and proteins), Female, Apolipoprotein E, Core laboratory, Hispanic Americans, medicine.medical_specialty, COA REDUCTASE INHIBITORS, European Continental Ancestry Group, Clinical Neurology, Raça, APOE EPSILON-4, White People, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Apolipoproteins E, Political science, medicine, Journal Article, Online First, Humans, Genetic Predisposition to Disease, cardiovascular diseases, General hospital, Aged, Cerebral Hemorrhage, Research, LOBAR, 3112 Neurosciences, E GENOTYPE, United States, nervous system diseases, Black or African American, Cognitive epidemiology, Family medicine, Case-Control Studies, Neurology (clinical), 030217 neurology & neurosurgery
Abstract: Key Points Question Is history of hypertension and apolipoprotein E (APOE) associated with intracerebral hemorrhage risk in participants stratified by self-reported race/ethnicity? Findings In this case-control study of 13 124 adults, having a copy of APOE ε4 alleles increased the risk for lobar intracerebral hemorrhage only in white individuals, but after propensity score matching for hypertension burden, Hispanic individuals showed the same risk of APOE ε4. Meaning APOE ε4 appears to be confirmed as a risk factor for lobar intracerebral hemorrhage in nonwhite populations but is masked by differential hypertension burden in Hispanic individuals; further studies are needed to explore the interactions between APOE alleles and environmental exposures., Importance Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Main Outcomes and Measures Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. Results In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ε2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P, This case-control study examines whether the risk for intracerebral hemorrhage presented by apolipoprotein E ε4 and ε2 alleles varies by race/ethnicity.
Published: 2019

176. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Author: Bentley, Amy R, Sung, Yun J, Brown, Michael R, Winkler, Thomas W, Kraja, Aldi T, Ntalla, Ioanna, Schwander, Karen, Chasman, Daniel I, Lim, Elise, Deng, Xuan, Guo, Xiuqing, Liu, Jingmin, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E, Musani, Solomon K, Li, Changwei, Feitosa, Mary F, Richard, Melissa A, Noordam, Raymond, Baker, Jenna, Chen, Guanjie, Aschard, Hugues, Bartz, Traci M, Ding, Jingzhong, Dorajoo, Rajkumar, Manning, Alisa K, Rankinen, Tuomo, Smith, Albert V, Tajuddin, Salman M, Zhao, Wei, Graff, Mariaelisa, Alver, Maris, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E, Hartwig, Fernando P, He, Meian, Horimoto, Andrea RVR, Hsu, Fang-Chi, Hung, Yi-Jen, Jackson, Anne U, Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Leander, Karin, Lin, Keng-Hung, Luan, Jian'an, Lyytikainen, Leo-Pekka, Matoba, Nana, Nolte, Ilja M, Pietzner, Maik, Prins, Bram, Riaz, Muhammad, Robino, Antonietta, Said, M Abdullah, Schupf, Nicole, Scott, Robert A, Sofer, Tamar, Stancakova, Alena, Takeuchi, Fumihiko, Tayo, Bamidele O, van der Most, Peter J, Varga, Tibor V, Wang, Tzung-Dau, Wang, Yajuan, Ware, Erin B, Wen, Wanqing, Xiang, Yong-Bing, Yanek, Lisa R, Zhang, Weihua, Zhao, Jing Hua, Adeyemo, Adebowale, Afaq, Saima, Amin, Najaf, Amini, Marzyeh, Arking, Dan E, Arzumanyan, Zorayr, Aung, Tin, Ballantyne, Christie, Barr, R Graham, Bielak, Lawrence F, Boerwinkle, Eric, Bottinger, Erwin P, Broeckel, Ulrich, Brown, Morris, Cade, Brian E, Campbell, Archie, Canouil, Mickael, Charumathi, Sabanayagam, Chen, Yii-Der Ida, Christensen, Kaare, Concas, Maria Pina, Connell, John M, de las Fuentes, Lisa, de Silva, H Janaka, de Vries, Paul S, Doumatey, Ayo, Duan, Qing, Eaton, Charles B, Eppinga, Ruben N, Faul, Jessica D, Floyd, James S, Forouhi, Nita G, Forrester, Terrence, Friedlander, Yechiel, Gandin, Ilaria, Gao, He, Ghanbari, Mohsen, Gharib, Sina A, Gigante, Bruna, Giulianini, Franco, Grabe, Hans J, Gu, C Charles, Harris, Tamara B, Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hixson, James E, Ikram, M Arfan, Jia, Yucheng, Joehanes, Roby, Johnson, Craig, Jonas, Jost Bruno, Justice, Anne E, Katsuya, Tomohiro, Khor, Chiea Chuen, Kilpelainen, Tuomas O, Koh, Woon-Puay, Kolcic, Ivana, Kooperberg, Charles, Krieger, Jose E, Kritchevsky, Stephen B, Kubo, Michiaki, Kuusisto, Johanna, Lakka, Timo A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lehne, Benjamin, Lewis, Cora E, Li, Yize, Liang, Jingjing, Lin, Shiow, Liu, Ching-Ti, Liu, Jianjun, Liu, Kiang, Loh, Marie, Lohman, Kurt K, Louie, Tin, Luzzi, Anna, Magi, Reedik, Mahajan, Anubha, Manichaikul, Ani W, McKenzie, Colin A, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mohlke, Karen L, Momozawa, Yukihide, Morris, Andrew P, Murray, Alison D, Nalls, Mike A, Nauck, Matthias, Nelson, Christopher P, North, Kari E, O'Connell, Jeffrey R, Palmer, Nicholette D, Papanicolau, George J, Pedersen, Nancy L, Peters, Annette, Peyser, Patricia A, Polasek, Ozren, Poulter, Neil, Raitakari, Olli T, Reiner, Alex P, Renstrom, Frida, Rice, Treva K, Rich, Stephen S, Robinson, Jennifer G, Rose, Lynda M, Rosendaal, Frits R, Rudan, Igor, Schmidt, Carsten O, Schreiner, Pamela J, Scott, William R, Sever, Peter, Shi, Yuan, Sidney, Stephen, Sims, Mario, Smith, Jennifer A, Snieder, Harold, Starr, John M, Strauch, Konstantin, Stringham, Heather M, Tan, Nicholas YQ, Tang, Hua, Taylor, Kent D, Teo, Yik Ying, Tham, Yih Chung, Tiemeier, Henning, Turner, Stephen T, Uitterlinden, Andre G, van Heemst, Diana, Waldenberger, Melanie, Wang, Heming, Wang, Lan, Wang, Lihua, Wei, Wen Bin, Williams, Christine A, Sr, Wilson Gregory, Wojczynski, Mary K, Yao, Jie, Young, Kristin, Yu, Caizheng, Yuan, Jian-Min, Zhou, Jie, Zonderman, Alan B, Becker, Diane M, Boehnke, Michael, Bowden, Donald W, Chambers, John C, Cooper, Richard S, de Faire, Ulf, Deary, Ian J, Elliott, Paul, Esko, Tonu, Farrall, Martin, Franks, Paul W, Freedman, Barry I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo L, Juang, Jyh-Ming Jimmy, Kamatani, Yoichiro, Kammerer, Candace M, Kato, Norihiro, Kooner, Jaspal S, Laakso, Markku, Laurie, Cathy C, Lee, I-Te, Lehtimaki, Terho, Magnusson, Patrik KE, Oldehinkel, Albertine J, Penninx, Brenda WJH, Pereira, Alexandre C, Rauramaa, Rainer, Redline, Susan, Samani, Nilesh J, Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E, Wang, Jun-Sing, Wang, Ya Xing, Wareham, Nicholas J, Watkins, Hugh, Weir, David R, Wickremasinghe, Ananda R, Wu, Tangchun, Zeggini, Eleftheria, Zheng, Wei, Bouchard, Claude, Evans, Michele K, Gudnason, Vilmundur, Kardia, Sharon LR, Liu, Yongmei, Psaty, Bruce M, Ridker, Paul M, van Dam, Rob M, Mook-Kanamori, Dennis O, Fornage, Myriam, Province, Michael A, Kelly, Tanika N, Fox, Ervin R, Hayward, Caroline, van Duijn, Cornelia M, Tai, E Shyong, Wong, Tien Yin, Loos, Ruth JF, Franceschini, Nora, Rotter, Jerome I, Zhu, Xiaofeng, Bierut, Laura J, Gauderman, W James, Rice, Kenneth, Munroe, Patricia B, Morrison, Alanna C, Rao, Dabeeru C, Rotimi, Charles N, Cupples, L Adrienne, Consortium, COGENT-Kidney, Consortium, EPIC-InterAct, Grp, Understanding Soc Sci, Cohort, Lifelines, National Institutes of Health [Bethesda] (NIH), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), The University of Texas Health Science Center at Houston (UTHealth), Universität Regensburg (UR), Queen Mary University of London (QMUL), Brigham and Women's Hospital [Boston], Harvard Medical School [Boston] (HMS), School of Public Health [Boston], Boston University [Boston] (BU), Los Angeles Biomedical Research Institute (LA BioMed), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Singapore Eye Research Institute [Singapore] (SERI), Duke-NUS Medical School [Singapore], National University of Singapore (NUS), Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Edinburgh, University of Mississippi Medical Center (UMMC), University of Georgia [USA], Leiden University Medical Center (LUMC), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Harvard T.H. Chan School of Public Health, University of Washington [Seattle], Wake Forest University, Genome Institute of Singapore (GIS), Massachusetts General Hospital [Boston], Pennington Biomedical Research Center, Louisiana State University (LSU), Icelandic Heart Association [Kopavogur, Iceland] (IHA), University of Iceland [Reykjavik], University of Michigan [Ann Arbor], University of Michigan System, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Tartu, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Karolinska Institutet [Stockholm], Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center, Imperial College London, University of Ioannina, University of Oxford [Oxford], University of Groningen [Groningen], Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), University of Bristol [Bristol], Huazhong University of Science and Technology [Wuhan] (HUST), Universidade de São Paulo Medical School (FMUSP), Case Western Reserve University [Cleveland], University of Southern California (USC), This project was largely supported by a grant from the US National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL118305) and by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362)., Bentley, Ar, Sung, Yj, Brown, Mr, Winkler, Tw, Kraja, At, Ntalla, I, Schwander, K, Chasman, Di, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, Cy, Sim, X, Vojinovic, D, Huffman, Je, Musani, Sk, Li, C, Feitosa, Mf, Richard, Ma, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, Tm, Ding, J, Dorajoo, R, Manning, Ak, Rankinen, T, Smith, Av, Tajuddin, Sm, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, Jf, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, Se, Hartwig, Fp, He, M, Horimoto, Arvr, Hsu, Fc, Hung, Yj, Jackson, Au, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lin, Kh, Luan, J, Lyytikäinen, Lp, Matoba, N, Nolte, Im, Pietzner, M, Prins, B, Riaz, M, Robino, A, Said, Ma, Schupf, N, Scott, Ra, Sofer, T, Stancáková, A, Takeuchi, F, Tayo, Bo, van der Most, Pj, Varga, Tv, Wang, Td, Wang, Y, Ware, Eb, Wen, W, Xiang, Yb, Yanek, Lr, Zhang, W, Zhao, Jh, Adeyemo, A, Afaq, S, Amin, N, Amini, M, Arking, De, Arzumanyan, Z, Aung, T, Ballantyne, C, Barr, Rg, Bielak, Lf, Boerwinkle, E, Bottinger, Ep, Broeckel, U, Brown, M, Cade, Be, Campbell, A, Canouil, M, Charumathi, S, Chen, Yi, Christensen, K, COGENT-Kidney, Consortium, Concas, Mp, Connell, Jm, de Las Fuentes, L, de Silva, Hj, de Vries, P, Doumatey, A, Duan, Q, Eaton, Cb, Eppinga, Rn, Faul, Jd, Floyd, J, Forouhi, Ng, Forrester, T, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gharib, Sa, Gigante, B, Giulianini, F, Grabe, Hj, Gu, Cc, Harris, Tb, Heikkinen, S, Heng, Ck, Hirata, M, Hixson, Je, Ikram, Ma, EPIC-InterAct, Consortium, Jia, Y, Joehanes, R, Johnson, C, Jonas, Jb, Justice, Ae, Katsuya, T, Khor, Cc, Kilpeläinen, To, Koh, Wp, Kolcic, I, Kooperberg, C, Krieger, Je, Kritchevsky, Sb, Kubo, M, Kuusisto, J, Lakka, Ta, Langefeld, Cd, Langenberg, C, Launer, Lj, Lehne, B, Lewis, Ce, Li, Y, Liang, J, Lin, S, Liu, Ct, Liu, K, Loh, M, Lohman, Kk, Louie, T, Luzzi, A, Mägi, R, Mahajan, A, Manichaikul, Aw, Mckenzie, Ca, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, Kl, Momozawa, Y, Morris, Ap, Murray, Ad, Nalls, Ma, Nauck, M, Nelson, Cp, North, Ke, O'Connell, Jr, Palmer, Nd, Papanicolau, Gj, Pedersen, Nl, Peters, A, Peyser, Pa, Polasek, O, Poulter, N, Raitakari, Ot, Reiner, Ap, Renström, F, Rice, Tk, Rich, S, Robinson, Jg, Rose, Lm, Rosendaal, Fr, Rudan, I, Schmidt, Co, Schreiner, Pj, Scott, Wr, Sever, P, Shi, Y, Sidney, S, Sims, M, Smith, Ja, Snieder, H, Starr, Jm, Strauch, K, Stringham, Hm, Tan, Nyq, Tang, H, Taylor, Kd, Teo, Yy, Tham, Yc, Tiemeier, H, Turner, St, Uitterlinden, Ag, Understanding Society Scientific, Group, van Heemst, D, Waldenberger, M, Wang, H, Wang, L, Wei, Wb, Williams, Ca, Wilson, G Sr, Wojczynski, Mk, Yao, J, Young, K, Yu, C, Yuan, Jm, Zhou, J, Zonderman, Ab, Becker, Dm, Boehnke, M, Bowden, Dw, Chambers, Jc, Cooper, R, de Faire, U, Deary, Ij, Elliott, P, Esko, T, Farrall, M, Franks, Pw, Freedman, Bi, Froguel, P, Gasparini, P, Gieger, C, Horta, Bl, Juang, Jj, Kamatani, Y, Kammerer, Cm, Kato, N, Kooner, J, Laakso, M, Laurie, Cc, Lee, It, Lehtimäki, T, Lifelines, Cohort, Magnusson, Pke, Oldehinkel, Aj, Penninx, Bwjh, Pereira, Ac, Rauramaa, R, Redline, S, Samani, Nj, Scott, J, Shu, Xo, van der Harst, P, Wagenknecht, Le, Wang, J, Wang, Yx, Wareham, Nj, Watkins, H, Weir, Dr, Wickremasinghe, Ar, Wu, T, Zeggini, E, Zheng, W, Bouchard, C, Evans, Mk, Gudnason, V, Kardia, Slr, Liu, Y, Psaty, Bm, Ridker, Pm, van Dam, Rm, Mook-Kanamori, Do, Fornage, M, Province, Ma, Kelly, Tn, Fox, Er, Hayward, C, van Duijn, Cm, Tai, E, Wong, Ty, Loos, Rjf, Franceschini, N, Rotter, Ji, Zhu, X, Bierut, Lj, Gauderman, Wj, Rice, K, Munroe, Pb, Morrison, Ac, Rao, Dc, Rotimi, Cn, Cupples, La., Luan, Jian'an [0000-0003-3137-6337], Pietzner, Maik [0000-0003-3437-9963], Zhao, Jing Hua [0000-0003-4930-3582], Forouhi, Nita [0000-0002-5041-248X], Langenberg, Claudia [0000-0002-5017-7344], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Epidemiology, Neurology, Radiology & Nuclear Medicine, Internal Medicine, Life Course Epidemiology (LCE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Cardiovascular Centre (CVC), Home Office, Action on Hearing Loss, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), Universiteit Leiden, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), University of Oxford, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, APH - Mental Health, and APH - Digital Health
Subjects: Male, Linkage disequilibrium, Blood lipids, Genome-wide association study, VARIANTS, SUSCEPTIBILITY, Environment interaction, Genome, Linkage Disequilibrium, MESH: Genotype, 0302 clinical medicine, MESH: Aged, 80 and over, Genotype, NICOTINE METABOLISM, 11 Medical and Health Sciences, Genetics & Heredity, Aged, 80 and over, Genetics, MESH: Aged, 0303 health sciences, ARCHITECTURE, [STAT.AP]Statistics [stat]/Applications [stat.AP], Genotype imputation, MESH: Middle Aged, CHOLESTEROL, Smoking, MESH: Life Style, Lifelines Cohort, Middle Aged, Lipids, 3. Good health, ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, RISK LOCI, METAANALYSIS, CIGARETTES, Cholesterol, MESH: Linkage Disequilibrium, MESH: Young Adult, Meta-analysis, Genome-Wide Association Study/methods, Smoking/blood, Medical genetics, Female, EPIC-InterAct Consortium, Life Sciences & Biomedicine, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Adult, Metaanalysi, Understanding Society Scientific Group, medicine.medical_specialty, MESH: Smoking, Adolescent, Genomics, COGENT-Kidney Consortium, Biology, Nicotine metabolism, Risk loci, Metaanalysis, Cigarettes, Article, Young Adult, 03 medical and health sciences, genomics, medicine, Humans, Linkage Disequilibrium/genetics, Life Style, Aged, 030304 developmental biology, MESH: Adolescent, Science & Technology, MESH: Humans, Lipids/blood, MESH: Adult, 06 Biological Sciences, MESH: Lipids, MESH: Male, cardiovascular diseases, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, genome-wide association studies, MESH: Genome-Wide Association Study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], MESH: Female, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study
Abstract: The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings., Editorial summary: A multi-ancestry genome-wide gene-smoking interaction study identifies 13 new loci associated with serum lipids.
Published: 2019

177. Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study

Author: Valdes-Marquez, Elsa, Parish, Sarah, Clarke, Robert, Stari, Traiani, Worrall, Bradford B, Hopewell, Jemma C, Slowik, Agnieszka, Hofman, Albert, Algra, Ale, Reiner, Alex P, Doney, Alexander SF, Gschwendtner, Andreas, Ilinca, Andreea, Giese, Anne-Katrin, Lindgren, Arne, Vicente, Astrid M, Norrving, Bo, Nordestgaard, Borge G, Mitchell, Braxton D, Psaty, Bruce M, Carty, Cara L, Sudlow, Cathie LM, Anderson, Christopher, Levi, Christopher R, Satizabal, Claudia L, Palmer, Colin NA, Gamble, Dale M, Woo, Daniel, Saleheen, Danish, Ringelstein, Bernd E, Valdimarsson, Einar M, Holliday, Elizabeth G, Davies, Gail, Chauhan, Ganesh, Pasterkamp, Gerard, Boncoraglio, Giorgio B, Kuhlenbaeumer, Gregor, Thorleifsson, Gudmar, Falcone, Guido J, Pare, Guillaume, Schmidt, Helena, Delavaran, Hossein, Markus, Hugh S, Aparicio, Hugo J, Deary, Ian, Cotlarciuc, Ioana, Fernandez-Cadenas, Israel, Meschia, James F, Liu, Jingmin, Montaner, Joan, Pera, Joanna, Cole, John, Attia, John R, Rosand, Jonathan, Ferro, Jose M, Bis, Joshua C, Furie, Karen, Stefansson, Kari, Berger, Klaus, Kostulas, Konstantinos, Rannikmae, Kristiina, Ikram, Arfan M, Benn, Marianne, Dichgans, Martin, Pandolfo, Massimo, Traylor, Matthew, Walters, Matthew, Sale, Michele, Nalls, Michael A, Fornage, Myriam, van Zuydam, Natalie R, Sharma, Pankaj, Abrantes, Patricia, de Bakker, Paul IW, Higgins, Peter, Lichtner, Peter, Rothwell, Peter M, Amouyel, Philippe, Yang, Qiong, Malik, Rainer, Schmidt, Reinhold, Lemmens, Robin, van der Laan, Sander W, Pulit, Sara L, Abboud, Sherine, Oliveira, Sofia A, Gretarsdottir, Solveig, Debette, Stephanie, Williams, Stephen R, Bevan, Steve, Kittner, Steven J, Seshadri, Sudha, Mosley, Thomas, Battey, Thomas WK, Tatlisumak, Turgut, Thorsteinsdottir, Unnur, Thijs, Vincent NS, Longstreth, WT, Zhao, Wei, Chen, Wei-Min, and Cheng, Yu-Ching
Subjects: Science & Technology, STATIN THERAPY, DENSITY-LIPOPROTEIN-CHOLESTEROL, Clinical Neurology, HEART-DISEASE, SUBTYPES, PCSK9, Centre for Brain Research, REDUCTION, BMI, GENETIC-VARIANTS, RISK-FACTORS, Neurosciences & Neurology, Life Sciences & Biomedicine, METAANALYSIS
Abstract: OBJECTIVE: To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach. METHODS: We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate the causal effects of LDL-C for IS and IS subtypes (based on 12,389 IS cases from METASTROKE) and for CHD (based on 60,801 cases from CARDIoGRAMplusC4D). We then assessed the effects of LDL-C on IS and CHD for heterogeneity. RESULTS: A 1 mmol/L higher genetically determined LDL-C was associated with a 50% higher risk of CHD (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.32-1.68, p = 1.1 × 10-8). By contrast, the causal effect of LDL-C was much weaker for IS (OR 1.12, 95% CI 0.96-1.30, p = 0.14; p for heterogeneity = 2.6 × 10-3) and, in particular, for cardioembolic stroke (OR 1.06, 95% CI 0.84-1.33, p = 0.64; p for heterogeneity = 8.6 × 10-3) when compared with that for CHD. CONCLUSIONS: In contrast with the consistent effects of LDL-C-lowering therapies on IS and CHD, genetic variants that confer lifelong LDL-C differences show a weaker effect on IS than on CHD. The relevance of etiologically distinct IS subtypes may contribute to the differences observed. ispartof: NEUROLOGY vol:92 issue:11 pages:E1176-E1187 ispartof: location:United States status: published
Published: 2019

178. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies

Author: Chen, Han, Huffman, Jennifer E, Brody, Jennifer A, Wang, Chaolong, Lee, Seunggeun, Li, Zilin, Gogarten, Stephanie M, Sofer, Tamar, Bielak, Lawrence F, Bis, Joshua C, Blangero, John, Bowler, Russell P, Cade, Brian E, Cho, Michael H, Correa, Adolfo, Curran, Joanne E, de Vries, Paul S, Glahn, David C, Guo, Xiuqing, Johnson, Andrew D, Kardia, Sharon, Kooperberg, Charles, Lewis, Joshua P, Liu, Xiaoming, Mathias, Rasika A, Mitchell, Braxton D, O'Connell, Jeffrey R, Peyser, Patricia A, Post, Wendy S, Reiner, Alex P, Rich, Stephen S, Rotter, Jerome I, Silverman, Edwin K, Smith, Jennifer A, Vasan, Ramachandran S, Wilson, James G, Yanek, Lisa R, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, Redline, Susan, Smith, Nicholas L, Boerwinkle, Eric, Borecki, Ingrid B, Cupples, L Adrienne, Laurie, Cathy C, Morrison, Alanna C, Rice, Kenneth M, and Lin, Xihong
Subjects: Male, relatedness, Time Factors, Population, TOPMed, Medical and Health Sciences, Chromosomes, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Genetic, Models, 2.5 Research design and methodologies (aetiology), and Blood Institute (U.S.), Genetics, Humans, Precision Medicine, Aetiology, Lung, Genetic Association Studies, Genetics & Heredity, variant set association test, Whole Genome Sequencing, Human Genome, Fibrinogen, rare variants, population structure, National Heart, Cloud Computing, Biological Sciences, United States, Good Health and Well Being, Pair 4, Research Design, generalized linear mixed model, whole-genome sequencing, Female, Generic health relevance, TOPMed Hematology and Hemostasis Working Group, Human, Biotechnology
Abstract: With advances in whole-genome sequencing (WGS) technology, more advanced statistical methods for testing genetic association with rare variants are being developed. Methods in which variants are grouped for analysis are also known as variant-set, gene-based, and aggregate unit tests. The burden test and sequence kernel association test (SKAT) are two widely used variant-set tests, which were originally developed for samples of unrelated individuals and later have been extended to family data with known pedigree structures. However, computationally efficient and powerful variant-set tests are needed to make analyses tractable in large-scale WGS studies with complex study samples. In this paper, we propose the variant-set mixed model association tests (SMMAT) for continuous and binary traits using the generalized linear mixed model framework. These tests can be applied to large-scale WGS studies involving samples with population structure and relatedness, such as in the National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine (TOPMed) program. SMMATs share the same null model for different variant sets, and a virtue of this null model, which includes covariates only, is that it needs to be fit only once for all tests in each genome-wide analysis. Simulation studies show that all the proposed SMMATs correctly control type I error rates for both continuous and binary traits in the presence of population structure and relatedness. We also illustrate our tests in a real data example of analysis of plasma fibrinogen levels in the TOPMed program (n = 23,763), using the Analysis Commons, a cloud-based computing platform.
Published: 2019

179. Correction: Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Author: Spracklen, Cassandra N., Karaderi, Tugce, Yaghootkar, Hanieh, Schurmann, Claudia, Fine, Rebecca S., Kutalik, Zoltan, Preuss, Michael H., Lu, Yingchang, Wittemans, Laura B. L., Adair, Linda S., Allison, Matthew, Amin, Najaf, Auer, Paul L., Bartz, Traci M., Blüher, Matthias, Boehnke, Michael, Borja, Judith B., Bork-Jensen, Jette, Broer, Linda, Chasman, Daniel I., Chen, Yii-Der Ida, Chirstofidou, Paraskevi, Demirkan, Ayse, van Duijn, Cornelia M., Feitosa, Mary F., Garcia, Melissa E., Graff, Mariaelisa, Grallert, Harald, Grarup, Niels, Guo, Xiuqing, Haesser, Jeffrey, Hansen, Torben, Harris, Tamara B., Highland, Heather M., Hong, Jaeyoung, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Rebecca, Jousilahti, Pekka, Kähönen, Mika, Kizer, Jorge R., Kovacs, Peter, Kriebel, Jennifer, Laakso, Markku, Lange, Leslie A., Lehtimäki, Terho, Li, Jin, Li-Gao, Ruifang, Lind, Lars, Luan, Jian'an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Mahajan, Anubha, Mangino, Massimo, Männistö, Satu, McCarthy, Mark I., McKnight, Barbara, Medina-Gomez, Carolina, Meigs, James B., Molnos, Sophie, Mook-Kanamori, Dennis, Morris, Andrew P., de Mutsert, Renee, Nalls, Mike A., Nedeljkovic, Ivana, North, Kari E., Pennell, Craig E., Pradhan, Aruna D., Province, Michael A., Raitakari, Olli T., Raulerson, Chelsea K., Reiner, Alex P., Ridker, Paul M., Ripatti, Samuli, Roberston, Neil, Rotter, Jerome I., Salomaa, Veikko, Sandoval-Zárate, America A., Sitlani, Colleen M., Spector, Tim D., Strauch, Konstantin, Stumvoll, Michael, Taylor, Kent D., Thuesen, Betina, Tönjes, Anke, Uitterlinden, Andre G., Venturini, Cristina, Walker, Mark, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Willems, Sara M., Willems van Dijk, Ko, Wilson, James G., Wu, Ying, Yao, Jie, Young, Kristin L., Langenberg, Claudia, Frayling, Timothy M., Kilpeläinen, Tuomas O., Lindgren, Cecilia M., Loos, Ruth J. F., and Mohlke, Karen L.
Subjects: SDG 3 - Good Health and Well-being
Published: 2019

180. Additional file 2: of Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Author: Schmidt, Amand, Holmes, Michael, Preiss, David, Swerdlow, Daniel, Denaxas, Spiros, Ghazaleh Fatemifar, Faraway, Rupert, Finan, Chris, Valentine, Dennis, Zammy Fairhurst-Hunter, Hartwig, Fernando, Horta, Bernardo, Hypponen, Elina, Power, Christine, Moldovan, Max, Iperen, Erik, Hovingh, Kees, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Goya Wanamethee, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie, Kivimaki, Mika, Welch, Catherine, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Nicolaides, Andrew, Andrie Panayiotou, N. Onland-Moret, Schouw, Yvonne, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas, Langenberg, Claudia, Scott, Robert, JianâAn Luan, Bobak, Martin, Malyutina, Sofia, K, Andrzej PajÄ, Ruzena Kubinova, Abdonas Tamosiunas, Pikhart, Hynek, Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Jess, Tine, Cooper, Jackie, Humphries, Steve, Brilliant, Murray, Kitchner, Terrie, Hakon Hakonarson, Carrell, David, McCarty, Catherine, Kirchner Lester, Larson, Eric, Crosslin, David, Mariza Andrade, Roden, Dan, Denny, Joshua, Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, Scott, Rodney, Schofield, Peter, OâDonnell, Martin, Yusuf, Salim, Chong, Michael, Pare, Guillaume, Harst, Pim, M. Said, Eppinga, Ruben, Verweij, Niek, Snieder, Harold, Christen, Tim, D. Mook-Kanamori, Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Raha Pazoki, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, DĂśrr, Marcus, Lerch, Markus, VĂślker, Uwe, VĂślzke, Henry, Ward, Joey, Pell, Jill, Meade, Tom, Christophersen, Ingrid, Zee, Anke Maitland-Van Der, Baranova, Ekaterina, Young, Robin, Ford, Ian, Campbell, Archie, Sandosh Padmanabhan, Bots, Michiel, Grobbee, Diederick, Froguel, Philippe, DorothĂŠe Thuillier, Roussel, Ronan, AmĂŠlie Bonnefond, Cariou, Bertrand, Smart, Melissa, Yanchun Bao, Kumari, Meena, Anubha Mahajan, Hopewell, Jemma, Seshadri, Sudha, Dale, Caroline, Costa, Rui, Ridker, Paul, Chasman, Daniel, Reiner, Alex, Ritchie, Marylyn, Lange, Leslie, Cornish, Alex, Dobbins, Sara, Hemminki, Kari, Kinnersley, Ben, Sanson, Marc, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Speedy, Helen, Allan, James, Li, Ni, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, BjĂśrn Nilsson, Goldschmidt, Hartmut, Sud, Amit, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert, Riyaz Patel, Keating, Brendan, Sattar, Naveed, Houlston, Richard, Casas, Juan, and Aroon Hingorani
Abstract: Supplemental figures and study acknowledgments. (PDF 154 kb)
Published: 2019
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181. African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Womenʼs Health Initiative

Author: Perez, Marco V., Hoffmann, Thomas J., Tang, Hua, Thornton, Timothy, Stefanick, Marcia L., Larson, Joseph C., Kooperberg, Charles, Reiner, Alex P., Caan, Bette, Iribarren, Carlos, and Risch, Neil
Published: 2013
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182. Esterified Estrogens and Conjugated Equine Estrogens and the Risk of Venous Thrombosis

Author: Smith, Nicholas L., Heckbert, Susan R., Lemaitre, Rozenn N., Reiner, Alex P., Lumley, Thomas, Weiss, Noel S., Larson, Eric B., Rosendaal, Frits R., and Psaty, Bruce M.
Published: 2004

183. A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans

Author: Hu, Yao, Raffield, Laura M., Polfus, Linda M., Moscati, Arden, Nadkarni, Girish, Preuss, Michael H., Zhong, Xue, Wei, Qiang, Rich, Stephen S., Li, Yun, Wilson, James G., Correa, Adolfo, Loos, Ruth J.F., Li, Bingshan, Auer, Paul L., Reiner, Alex P., and the NHLBI Trans-Omics for Precision Medicine Consortium
Published: 2018
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184. Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project

Author: Hu, Yao, Haessler, Jeffrey W., Manansala, Regina, Wiggins, Kerri L., Moscati, Arden, Beiser, Alexa, Heard-Costa, Nancy L., Sarnowski, Chloe, Raffield, Laura M., Chung, Jaeyoon, Marini, Sandro, Anderson, Christopher D., Rosand, Jonathan, Xu, Huichun, Sun, Xiao, Kelly, Tanika N., Wong, Quenna, Lange, Leslie A., Rotter, Jerome I., Correa, Adolfo, Vasan, Ramachandran S., Seshadri, Sudha, Rich, Stephen S., Do, Ron, Loos, Ruth J.F., Longstreth, William T., Bis, Joshua C., Psaty, Bruce M., Tirschwell, David L., Assimes, Themistocles L., Silver, Brian, Liu, Simin, Jackson, Rebecca, Wassertheil-Smoller, Sylvia, Mitchell, Braxton D., Fornage, Myriam, Auer, Paul L., Reiner, Alex P., and Kooperberg, Charles
Abstract: Supplemental Digital Content is available in the text.
Published: 2022
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185. Genetic diversity fuels gene discovery for tobacco and alcohol use

Author: Saunders, Gretchen R. B., Wang, Xingyan, Chen, Fang, Jang, Seon-Kyeong, Liu, Mengzhen, Wang, Chen, Gao, Shuang, Jiang, Yu, Khunsriraksakul, Chachrit, Otto, Jacqueline M., Addison, Clifton, Akiyama, Masato, Albert, Christine M., Aliev, Fazil, Alonso, Alvaro, Arnett, Donna K., Ashley-Koch, Allison E., Ashrani, Aneel A., Barnes, Kathleen C., Barr, R. Graham, Bartz, Traci M., Becker, Diane M., Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Bleecker, Eugene R., Boardman, Jason D., Boerwinkle, Eric, Boomsma, Dorret I., Boorgula, Meher Preethi, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Chasman, Daniel I., Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Cho, Michael H., Choquet, Hélène, Cole, John W., Cornelis, Marilyn C., Cucca, Francesco, Curran, Joanne E., de Andrade, Mariza, Dick, Danielle M., Docherty, Anna R., Duggirala, Ravindranath, Eaton, Charles B., Ehringer, Marissa A., Esko, Tõnu, Faul, Jessica D., Silva, Lilian Fernandes, Fiorillo, Edoardo, Fornage, Myriam, Freedman, Barry I., Gabrielsen, Maiken E., Garrett, Melanie E., Gharib, Sina A., Gieger, Christian, Gillespie, Nathan, Glahn, David C., Gordon, Scott D., Gu, Charles C., Gu, Dongfeng, Gudbjartsson, Daniel F., Guo, Xiuqing, Haessler, Jeffrey, Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Herd, Pamela, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hopfer, Christian, Hottenga, JoukeJan, Hou, Lifang, Huang, Hongyan, Hung, Yi-Jen, Hunter, David J., Hveem, Kristian, Hwang, Shih-Jen, Hwu, Chii-Min, Iacono, William, Irvin, Marguerite R., Jee, Yon Ho, Johnson, Eric O., Joo, Yoonjung Y., Jorgenson, Eric, Justice, Anne E., Kamatani, Yoichiro, Kaplan, Robert C., Kaprio, Jaakko, Kardia, Sharon L. R., Keller, Matthew C., Kelly, Tanika N., Kooperberg, Charles, Korhonen, Tellervo, Kraft, Peter, Krauter, Kenneth, Kuusisto, Johanna, Laakso, Markku, Lasky-Su, Jessica, Lee, Wen-Jane, Lee, James J., Levy, Daniel, Li, Liming, Li, Kevin, Li, Yuqing, Lin, Kuang, Lind, Penelope A., Liu, Chunyu, Lloyd-Jones, Donald M., Lutz, Sharon M., Ma, Jiantao, Mägi, Reedik, Manichaikul, Ani, Martin, Nicholas G., Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Meyers, Deborah A., Millwood, Iona Y., Mitchell, Braxton D., Mohlke, Karen L., Moll, Matthew, Montasser, May E., Morrison, Alanna C., Mulas, Antonella, Nielsen, Jonas B., North, Kari E., Oelsner, Elizabeth C., Okada, Yukinori, Orrù, Valeria, Palmer, Nicholette D., Palviainen, Teemu, Pandit, Anita, Park, S. Lani, Peters, Ulrike, Peters, Annette, Peyser, Patricia A., Polderman, Tinca J. C., Rafaels, Nicholas, Redline, Susan, Reed, Robert M., Reiner, Alex P., Rice, John P., Rich, Stephen S., Richmond, Nicole E., Roan, Carol, Rotter, Jerome I., Rueschman, Michael N., Runarsdottir, Valgerdur, Saccone, Nancy L., Schwartz, David A., Shadyab, Aladdin H., Shi, Jingchunzi, Shringarpure, Suyash S., Sicinski, Kamil, Skogholt, Anne Heidi, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Stefansson, Kari, Stitzel, Jerry A., Sun, Xiao, Syed, Moin, Tal-Singer, Ruth, Taylor, Amy E., Taylor, Kent D., Telen, Marilyn J., Thai, Khanh K., Tiwari, Hemant, Turman, Constance, Tyrfingsson, Thorarinn, Wall, Tamara L., Walters, Robin G., Weir, David R., Weiss, Scott T., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Winsvold, Bendik S., Xu, Huichun, Yanek, Lisa R., Yin, Jie, Young, Kristin L., Young, Kendra A., Yu, Bing, Zhao, Wei, Zhou, Wei, Zöllner, Sebastian, Zuccolo, Luisa, Batini, Chiara, Bergen, Andrew W., Bierut, Laura J., David, Sean P., Gagliano Taliun, Sarah A., Hancock, Dana B., Jiang, Bibo, Munafò, Marcus R., Thorgeirsson, Thorgeir E., Liu, Dajiang J., and Vrieze, Scott
Abstract: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries5. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.
Published: 2022
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186. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author: Turcot, Valérie, Lu, Yingchang, Highland, Heather M, Schurmann, Claudia, Justice, Anne E, Fine, Rebecca S, Bradfield, Jonathan P, Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E, Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E, Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L, Alfred, Tamuno, Feitosa, Mary F, Masca, Nicholas GD, Manning, Alisa K, Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie CY, Reiner, Alex P, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Abecasis, Gonçalo, Aben, Katja K, Alam, Dewan S, Alharthi, Sameer E, Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Bang, Lia E, Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Brumat, Marco, Burt, Amber A, Butterworth, Adam S, Campbell, Peter T, Cappellani, Stefania, Carey, David J, Catamo, Eulalia, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der I, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J, Crosslin, David S, Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul IW, Groot, Mark CH, Mutsert, Renée, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, Heijer, Martin, Hollander, Anneke I, Ruijter, Hester M, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M, and Easton, Douglas F
Subjects: INTERVAL Study, ReproGen Consortium, Understanding Society Scientific Group, CHD Exome+ Consortium, T2D-Genes Consortium, Biological Sciences, Medical and Health Sciences, EPIC-CVD Consortium, MAGIC Investigators, GoT2D Genes Consortium, Global Lipids Genetic Consortium, EPIC InterAct Consortium, Obesity, ExomeBP Consortium, Nutrition, Developmental Biology
Abstract: In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.
Published: 2018

187. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author: Turcot, Valérie, Lu, Yingchang, Highland, Heather M, Schurmann, Claudia, Justice, Anne E, Fine, Rebecca S, Bradfield, Jonathan P, Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E, Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E, Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L, Alfred, Tamuno, Feitosa, Mary F, Masca, Nicholas GD, Manning, Alisa K, Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie CY, Reiner, Alex P, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Abecasis, Gonçalo, Aben, Katja K, Alam, Dewan S, Alharthi, Sameer E, Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Bang, Lia E, Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Brumat, Marco, Burt, Amber A, Butterworth, Adam S, Campbell, Peter T, Cappellani, Stefania, Carey, David J, Catamo, Eulalia, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der I, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J, Crosslin, David S, Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul IW, Groot, Mark CH, Mutsert, Renée, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, Heijer, Martin, Hollander, Anneke I, Ruijter, Hester M, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M, and Easton, Douglas F
Subjects: INTERVAL Study, Adult, Male, ReproGen Consortium, Understanding Society Scientific Group, Cardiovascular, Medical and Health Sciences, EPIC-CVD Consortium, Oral and gastrointestinal, Body Mass Index, MAGIC Investigators, Gene Frequency, Genetics, Animals, Humans, 2.1 Biological and endogenous factors, Global Lipids Genetic Consortium, Obesity, Aetiology, Metabolic and endocrine, Nutrition, Cancer, CHD Exome+ Consortium, Human Genome, Proteins, Genetic Variation, T2D-Genes Consortium, Syndrome, Biological Sciences, Stroke, GoT2D Genes Consortium, Drosophila, Female, EPIC InterAct Consortium, ExomeBP Consortium, Energy Metabolism, Energy Intake, Biotechnology, Developmental Biology
Abstract: Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observedto be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMIconfirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Published: 2018

188. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Author: Spracklen, Cassandra N., primary, Karaderi, Tugce, additional, Yaghootkar, Hanieh, additional, Schurmann, Claudia, additional, Fine, Rebecca S., additional, Kutalik, Zoltan, additional, Preuss, Michael H., additional, Lu, Yingchang, additional, Wittemans, Laura B.L., additional, Adair, Linda S., additional, Allison, Matthew, additional, Amin, Najaf, additional, Auer, Paul L., additional, Bartz, Traci M., additional, Blüher, Matthias, additional, Boehnke, Michael, additional, Borja, Judith B., additional, Bork-Jensen, Jette, additional, Broer, Linda, additional, Chasman, Daniel I., additional, Chen, Yii-Der Ida, additional, Chirstofidou, Paraskevi, additional, Demirkan, Ayse, additional, van Duijn, Cornelia M., additional, Feitosa, Mary F., additional, Garcia, Melissa E., additional, Graff, Mariaelisa, additional, Grallert, Harald, additional, Grarup, Niels, additional, Guo, Xiuqing, additional, Haesser, Jeffrey, additional, Hansen, Torben, additional, Harris, Tamara B., additional, Highland, Heather M., additional, Hong, Jaeyoung, additional, Ikram, M. Arfan, additional, Ingelsson, Erik, additional, Jackson, Rebecca, additional, Jousilahti, Pekka, additional, Kähönen, Mika, additional, Kizer, Jorge R., additional, Kovacs, Peter, additional, Kriebel, Jennifer, additional, Laakso, Markku, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Li, Jin, additional, Li-Gao, Ruifang, additional, Lind, Lars, additional, Luan, Jian’an, additional, Lyytikäinen, Leo-Pekka, additional, MacGregor, Stuart, additional, Mackey, David A., additional, Mahajan, Anubha, additional, Mangino, Massimo, additional, Männistö, Satu, additional, McCarthy, Mark I., additional, McKnight, Barbara, additional, Medina-Gomez, Carolina, additional, Meigs, James B., additional, Molnos, Sophie, additional, Mook-Kanamori, Dennis, additional, Morris, Andrew P., additional, de Mutsert, Renee, additional, Nalls, Mike A., additional, Nedeljkovic, Ivana, additional, North, Kari E., additional, Pennell, Craig E., additional, Pradhan, Aruna D., additional, Province, Michael A., additional, Raitakari, Olli T., additional, Raulerson, Chelsea K., additional, Reiner, Alex P., additional, Ridker, Paul M., additional, Ripatti, Samuli, additional, Roberston, Neil, additional, Rotter, Jerome I., additional, Salomaa, Veikko, additional, Sandoval-Zárate, America A., additional, Sitlani, Colleen M., additional, Spector, Tim D., additional, Strauch, Konstantin, additional, Stumvoll, Michael, additional, Taylor, Kent D., additional, Thuesen, Betina, additional, Tönjes, Anke, additional, Uitterlinden, Andre G., additional, Venturini, Cristina, additional, Walker, Mark, additional, Wang, Carol A., additional, Wang, Shuai, additional, Wareham, Nicholas J., additional, Willems, Sara M., additional, Willems van Dijk, Ko, additional, Wilson, James G., additional, Wu, Ying, additional, Yao, Jie, additional, Young, Kristin L., additional, Langenberg, Claudia, additional, Frayling, Timothy M., additional, Kilpeläinen, Tuomas O., additional, Lindgren, Cecilia M., additional, Loos, Ruth J.F., additional, and Mohlke, Karen L., additional
Published: 2019
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189. Epigenome-wide association study of leukocyte telomere length

Author: Lee, Yunsung, primary, Sun, Dianjianyi, additional, Ori, Anil P.S., additional, Lu, Ake T., additional, Seeboth, Anne, additional, Harris, Sarah E., additional, Deary, Ian J., additional, Marioni, Riccardo E., additional, Soerensen, Mette, additional, Mengel-From, Jonas, additional, Hjelmborg, Jacob, additional, Christensen, Kaare, additional, Wilson, James G., additional, Levy, Daniel, additional, Reiner, Alex P., additional, Chen, Wei, additional, Li, Shengxu, additional, Harris, Jennifer R., additional, Magnus, Per, additional, Aviv, Abraham, additional, Jugessur, Astanand, additional, and Horvath, Steve, additional
Published: 2019
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190. DNA methylation-based estimator of telomere length

Author: Lu, Ake T., primary, Seeboth, Anne, additional, Tsai, Pei-Chien, additional, Sun, Dianjianyi, additional, Quach, Austin, additional, Reiner, Alex P., additional, Kooperberg, Charles, additional, Ferrucci, Luigi, additional, Hou, Lifang, additional, Baccarelli, Andrea A., additional, Li, Yun, additional, Harris, Sarah E., additional, Corley, Janie, additional, Taylor, Adele, additional, Deary, Ian J., additional, Stewart, James D., additional, Whitsel, Eric A., additional, Assimes, Themistocles L., additional, Chen, Wei, additional, Li, Shengxu, additional, Mangino, Massimo, additional, Bell, Jordana T., additional, Wilson, James G., additional, Aviv, Abraham, additional, Marioni, Riccardo E., additional, Raj, Kenneth, additional, and Horvath, Steve, additional
Published: 2019
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191. Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

Author: Baldassari, Antoine R., primary, Sitlani, Colleen M., additional, Highland, Heather M., additional, Arking, Dan E., additional, Buyske, Steve, additional, Darbar, Dawood, additional, Gondalia, Rahul, additional, Graff, Misa, additional, Guo, Xiuqing, additional, Heckbert, Susan R., additional, Hindorff, Lucia A., additional, Hodonsky, Chani J., additional, Ida Chen, Yii-Der, additional, Kaplan, Robert C., additional, Peters, Ulrike, additional, Post, Wendy, additional, Reiner, Alex P., additional, Rotter, Jerome I., additional, Shohet, Ralph V., additional, Seyerle, Amanda A., additional, Sotoodehnia, Nona, additional, Tao, Ran, additional, Taylor, Kent D., additional, Wojcik, Genevieve L, additional, Yao, Jie, additional, Kenny, Eimear E., additional, Lin, Henry J., additional, Soliman, Elsayed Z., additional, Whitsel, Eric A., additional, North, Kari E., additional, Kooperberg, Charles, additional, and Avery, Christy L., additional
Published: 2019
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192. A Cross-Sectional Analysis of Telomere Length and Sleep in the Women’s Health Initiative

Author: Grieshober, Laurie, primary, Wactawski-Wende, Jean, additional, Hageman Blair, Rachael, additional, Mu, Lina, additional, Liu, Jingmin, additional, Nie, Jing, additional, Carty, Cara L, additional, Hale, Lauren, additional, Kroenke, Candyce H, additional, LaCroix, Andrea Z, additional, Reiner, Alex P, additional, and Ochs-Balcom, Heather M, additional
Published: 2019
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193. Abstract P032: Soluble CD14 Level is a Coronary Heart Disease Risk Factor in Younger-aged Black Adults of the Reasons for Geographical and Racial Differences in Stroke (REGARDS) Study

Author: Olson, Nels C, primary, Koh, Insu, additional, Reiner, Alex P, additional, Judd, Suzanne E, additional, Irvin, Marguerite R, additional, Howard, George, additional, Zakai, Neil A, additional, and Cushman, Mary, additional
Published: 2019
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194. Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

Author: Wang, Zhe, primary, Chen, Han, additional, Bartz, Traci M., additional, Bielak, Lawrence F., additional, Chasman, Daniel I., additional, Feitosa, Mary F., additional, Franceschini, Nora, additional, Guo, Xiuqing, additional, Lim, Elise, additional, Noordam, Raymond, additional, Richard, Melissa A., additional, Wang, Heming, additional, Cade, Brian, additional, Adrienne Cupples, L., additional, de Vries, Paul S., additional, Giulanini, Franco, additional, Lee, Jiwon, additional, Lemaitre, Rozenn N., additional, Martin, Lisa W., additional, Reiner, Alex P., additional, Rich, Stephen S., additional, Schreiner, Pamela J., additional, Sidney, Stephen, additional, Sitlani, Colleen M., additional, Smith, Jennifer A., additional, van Dijk, Ko Willems, additional, Yao, Jie, additional, Zhao, Wei, additional, Fornage, Myriam, additional, Kardia, Sharon L.R., additional, Kooperberg, Charles, additional, Liu, Ching-Ti, additional, Mook-Kanamori, Dennis O, additional, Province, Michael A., additional, Psaty, Bruce M., additional, Redline, Susan, additional, Ridker, Paul M., additional, Rotter, Jerome I., additional, Boerwinkle, Eric, additional, and Morrison, Alanna C., additional
Published: 2019
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195. Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

Author: Noordam, Raymond, primary, Bos, Maxime M, additional, Wang, Heming, additional, Winkler, Thomas W, additional, Bentley, Amy R, additional, Kilpeläinen, Tuomas O., additional, de Vries, Paul S, additional, Sung, Yun Ju, additional, Schwander, Karen, additional, Cade, Brian E, additional, Manning, Alisa, additional, Aschard, Hugues, additional, Brown, Michael R, additional, Chen, Han, additional, Franceschini, Nora, additional, Musani, Solomon K, additional, Richard, Melissa, additional, Vojinovic, Dina, additional, Aslibekyan, Stella, additional, Bartz, Traci M, additional, de las Fuentes, Lisa, additional, Feitosa, Mary, additional, Horimoto, Andrea R, additional, Ilkov, Marjan, additional, Kho, Minjung, additional, Kraja, Aldi, additional, Li, Changwei, additional, Lim, Elise, additional, Liu, Yongmei, additional, Mook-Kanamori, Dennis O, additional, Rankinen, Tuomo, additional, Tajuddin, Salman M, additional, van der Spek, Ashley, additional, Wang, Zhe, additional, Marten, Jonathan, additional, Laville, Vincent, additional, Alver, Maris, additional, Evangelou, Evangelos, additional, Graff, Maria E, additional, He, Meian, additional, Kühnel, Brigitte, additional, Lyytikäinen, Leo-Pekka, additional, Marques-Vidal, Pedro, additional, Nolte, Ilja M, additional, Palmer, Nicholette D, additional, Rauramaa, Rainer, additional, Shu, Xiao-Ou, additional, Snieder, Harold, additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Yanek, Lisa R, additional, Adolfo, Correa, additional, Ballantyne, Christie, additional, Bielak, Larry, additional, Biermasz, Nienke R, additional, Boerwinkle, Eric, additional, Dimou, Niki, additional, Eiriksdottir, Gudny, additional, Gao, Chuan, additional, Gharib, Sina A, additional, Gottlieb, Daniel J, additional, Haba-Rubio, José, additional, Harris, Tamara B, additional, Heikkinen, Sami, additional, Heinzer, Raphaël, additional, Hixson, James E, additional, Homuth, Georg, additional, Ikram, M Arfan, additional, Komulainen, Pirjo, additional, Krieger, Jose E, additional, Lee, Jiwon, additional, Liu, Jingmin, additional, Lohman, Kurt K, additional, Luik, Annemarie I, additional, Mägi, Reedik, additional, Martin, Lisa W, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Milaneschi, Yuri, additional, Nalls, Mike A, additional, O’Connell, Jeff, additional, Peters, Annette, additional, Peyser, Patricia, additional, Raitakari, Olli T, additional, Reiner, Alex P, additional, Rensen, Patrick CN, additional, Rice, Treva K, additional, Rich, Stephen S, additional, Roenneberg, Till, additional, Rotter, Jerome I, additional, Schreiner, Pamela J, additional, Shikany, James, additional, Sidney, Stephen S, additional, Sims, Mario, additional, Sitlani, Colleen M, additional, Sofer, Tamar, additional, Strauch, Konstantin, additional, Swertz, Morris A, additional, Taylor, Kent D, additional, Uitterlinden, André G, additional, Duijn, Cornelia M van, additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Wallance, Robert B, additional, Dijk, Ko Willems van, additional, Yu, Caizheng, additional, Zonderman, Alan B, additional, Becker, Diane M, additional, Elliott, Paul, additional, Esko, Tõnu, additional, Gieger, Christian, additional, Grabe, Hans J, additional, Lakka, Timo A, additional, Lehtimäki, Terho, additional, Study, Lifelines Cohort, additional, North, Kari E, additional, Penninx, Brenda WJH, additional, Vollenweider, Peter, additional, Wagenknecht, Lynne E, additional, Wu, Tangchun, additional, Xiang, Yong-Bing, additional, Zheng, Wei, additional, Arnett, Donna K, additional, Bouchard, Claude, additional, Evans, Michele K, additional, Gudnason, Vilmundur, additional, Kardia, Sharon, additional, Kelly, Tanika N, additional, Kritchevsky, Stephen B, additional, Loos, Ruth JF, additional, Pereira, Alexandre C, additional, Province, Mike, additional, Psaty, Bruce M, additional, Rotimi, Charles, additional, Zhu, Xiaofeng, additional, Amin, Najaf, additional, Cupples, L Adrienne, additional, Fornage, Myriam, additional, Fox, Ervin F, additional, Guo, Xiuqing, additional, Gauderman, W James, additional, Rice, Kenneth, additional, Kooperberg, Charles, additional, Munroe, Patricia B, additional, Liu, Ching-Ti, additional, Morrison, Alanna C, additional, Rao, Dabeeru C, additional, Heemst, Diana van, additional, and Redline, Susan, additional
Published: 2019
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196. Abstract 10: Higher Soluble CD14 Level is a Risk Factor for Ischemic Stroke in Black but Not White Participants of the Reasons for Geographical and Racial Differences in Stroke (REGARDS) Study

Author: Olson, Nels C, primary, Koh, Insu, additional, Reiner, Alex P, additional, Judd, Suzanne E, additional, Irvin, Marguerite R, additional, Howard, George, additional, Zakai, Neil A, additional, and Cushman, Mary, additional
Published: 2019
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197. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies

Author: Chen, Han, primary, Huffman, Jennifer E., additional, Brody, Jennifer A., additional, Wang, Chaolong, additional, Lee, Seunggeun, additional, Li, Zilin, additional, Gogarten, Stephanie M., additional, Sofer, Tamar, additional, Bielak, Lawrence F., additional, Bis, Joshua C., additional, Blangero, John, additional, Bowler, Russell P., additional, Cade, Brian E., additional, Cho, Michael H., additional, Correa, Adolfo, additional, Curran, Joanne E., additional, de Vries, Paul S., additional, Glahn, David C., additional, Guo, Xiuqing, additional, Johnson, Andrew D., additional, Kardia, Sharon, additional, Kooperberg, Charles, additional, Lewis, Joshua P., additional, Liu, Xiaoming, additional, Mathias, Rasika A., additional, Mitchell, Braxton D., additional, O’Connell, Jeffrey R., additional, Peyser, Patricia A., additional, Post, Wendy S., additional, Reiner, Alex P., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Silverman, Edwin K., additional, Smith, Jennifer A., additional, Vasan, Ramachandran S., additional, Wilson, James G., additional, Yanek, Lisa R., additional, Redline, Susan, additional, Smith, Nicholas L., additional, Boerwinkle, Eric, additional, Borecki, Ingrid B., additional, Cupples, L. Adrienne, additional, Laurie, Cathy C., additional, Morrison, Alanna C., additional, Rice, Kenneth M., additional, and Lin, Xihong, additional
Published: 2019
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198. DNA methylation GrimAge strongly predicts lifespan and healthspan

Author: Lu, Ake T., primary, Quach, Austin, additional, Wilson, James G., additional, Reiner, Alex P., additional, Aviv, Abraham, additional, Raj, Kenneth, additional, Hou, Lifang, additional, Baccarelli, Andrea A., additional, Li, Yun, additional, Stewart, James D., additional, Whitsel, Eric A., additional, Assimes, Themistocles L., additional, Ferrucci, Luigi, additional, and Horvath, Steve, additional
Published: 2019
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199. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016)

Author: Stitziel, Nathan O, Stirrups, Kathleen E, Masca, Nicholas GD, Erdmann, Jeanette, Ferrario, Paola G, Koenig, Inke R, Weeke, Peter E, Webb, Thomas R, Auer, Paul L, Schick, Ursula M, Lu, Yingchang, Zhang, He, Dube, Marie-Pierre, Goel, Anuj, Farrall, Martin, Peloso, Gina M, Won, Hong-Hee, Do, Ron, Van Iperen, Erik, Kanoni, Stavroula, Kruppa, Jochen, Mahajan, Anubha, Scott, Robert A, Willenborg, Christina, Braund, Peter S, Van Capelleveen, Julian C, Doney, Alex SF, Donnelly, Louise A, Asselta, Rosanna, Merlini, Piera A, Duga, Stefano, Marziliano, Nicola, Denny, Josh C, Shaffer, Christian M, El-Mokhtari, Nour Eddine, Franke, Andre, Gottesman, Omri, Heilmann, Stefanie, Hengstenberg, Christian, Hoffmann, Per, Holmen, Oddgeir L, Hveem, Kristian, Jansson, Jan-Hakan, Joeckel, Karl-Heinz, Kessler, Thorsten, Kriebel, Jennifer, Laugwitz, Karl L, Marouli, Eirini, Martinelli, Nicola, McCarthy, Mark I, Van Zuydam, Natalie R, Meisinger, Christa, Esko, Tonu, Mihailov, Evelin, Escher, Stefan A, Alver, Maris, Moebus, Susanne, Morris, Andrew D, Muller-Nurasyid, Martina, Nikpay, Majid, Olivieri, Oliviero, Perreault, Louis-Philippe Lemieux, AlQarawi, Alaa, Robertson, Neil R, Akinsanya, Karen O, Reilly, Dermot F, Vogt, Thomas F, Yin, Wu, Asselbergs, Folkert W, Kooperberg, Charles, Jackson, Rebecca D, Stahl, Eli, Strauch, Konstantin, Varga, Tibor V, Waldenberger, Melanie, Zeng, Lingyao, Kraja, Aldi T, Liu, Chunyu, Ehret, Georg B, Newton-Cheh, Christopher, Chasman, Daniel I, Chowdhury, Rajiv, Ferrario, Marco, Ford, Ian, Jukema, J Wouter, Kee, Frank, Kuulasmaa, Kari, Nordestgaard, Borge G, Perola, Markus, Saleheen, Danish, Sattar, Naveed, Surendran, Praveen, Tregouet, David, Young, Robin, Howson, Joanna MM, Butterworth, Adam S, Danesh, John, Ardissino, Diego, Bottinger, Erwin P, Erbel, Raimund, Franks, Paul W, Girelli, Domenico, Hall, Alistair S, Hovingh, G Kees, Kastrati, Adnan, Lieb, Wolfgang, Meitinger, Thomas, Kraus, William E, Shah, Svati H, McPherson, Ruth, Orho-Melander, Marju, Melander, Olle, Metspalu, Andres, Palmer, Colin NA, Peters, Annette, Rader, Daniel J, Reilly, Muredach P, Loos, Ruth JF, Reiner, Alex P, Roden, Dan M, Tardif, Jean-Claude, Thompson, John R, Wareham, Nicholas J, Watkins, Hugh, Willer, Cristen J, Kathiresan, Sekar, Deloukas, Panos, Samani, Nilesh J, Schunkert, Heribert, Other departments, Vascular Medicine, Johnson, Kathleen [0000-0002-6823-3252], Surendran, Praveen [0000-0002-4911-6077], Danesh, John [0000-0003-1158-6791], Wareham, Nicholas [0000-0003-1422-2993], and Apollo - University of Cambridge Repository
Subjects: 03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology
Abstract: BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. RESULTS We confirmed previously observed significant associations between coronary artery disease and low-frequency missense variants in the genes LPA and PCSK9. We also found significant associations between coronary artery disease and low-frequency missense variants in the genes SVEP1 (p.D2702G; minor-allele frequency, 3.60%; odds ratio for disease, 1.14; P=4.2×10−10) and ANGPTL4 (p.E40K; minor-allele frequency, 2.01%; odds ratio, 0.86; P=4.0×10−8), which encodes angiopoietin-like 4. Through sequencing of ANGPTL4, we identified 9 carriers of loss-of-function mutations among 6924 patients with myocardial infarction, as compared with 19 carriers among 6834 controls (odds ratio, 0.47; P=0.04); carriers of ANGPTL4 loss-of-function alleles had triglyceride levels that were 35% lower than the levels among persons who did not carry a loss-of-function allele (P=0.003). ANGPTL4 inhibits lipoprotein lipase; we therefore searched for mutations in LPL and identified a loss-of-function variant that was associated with an increased risk of coronary artery disease (p.D36N; minor-allele frequency, 1.9%; odds ratio, 1.13; P=2.0×10−4) and a gain-of-function variant that was associated with protection from coronary artery disease (p.S447*; minor-allele frequency, 9.9%; odds ratio, 0.94; P=2.5×10−7). CONCLUSIONS We found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease. (Funded by the National Institutes of Health and others.)
Published: 2017
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200. Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study

Author: Jordan, Christina D., primary, Glover, LáShauntá M., additional, Gao, Yan, additional, Musani, Solomon K., additional, Mwasongwe, Stanford, additional, Wilson, James G., additional, Reiner, Alex, additional, Diez‐Roux, Ana, additional, and Sims, Mario, additional
Published: 2018
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