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11,576 results on '"Reiff, A."'

152. The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell

Author

Slabodnick, Mark M, Ruby, J Graham, Reiff, Sarah B, Swart, Estienne C, Gosai, Sager, Prabakaran, Sudhakaran, Witkowska, Ewa, Larue, Graham E, Fisher, Susan, Freeman, Robert M, Gunawardena, Jeremy, Chu, William, Stover, Naomi A, Gregory, Brian D, Nowacki, Mariusz, Derisi, Joseph, Roy, Scott W, Marshall, Wallace F, and Sood, Pranidhi

Subjects
Biological Sciences, Genetics, Regenerative Medicine, Human Genome, Biotechnology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Ciliophora, Genome, Protozoan, Introns, Phylogeny, Spliceosomes, Whole Genome Sequencing, U2 snRNA, cell size, ciliate, genetic code, heterotrichidae, intron evolution, macronucleus, ploidy, regeneration, splicing, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Psychology
Abstract

The giant, single-celled organism Stentor coeruleus has a long history as a model system for studying pattern formation and regeneration in single cells. Stentor [1, 2] is a heterotrichous ciliate distantly related to familiar ciliate models, such as Tetrahymena or Paramecium. The primary distinguishing feature of Stentor is its incredible size: a single cell is 1 mm long. Early developmental biologists, including T.H. Morgan [3], were attracted to the system because of its regenerative abilities-if large portions of a cell are surgically removed, the remnant reorganizes into a normal-looking but smaller cell with correct proportionality [2, 3]. These biologists were also drawn to Stentor because it exhibits a rich repertoire of behaviors, including light avoidance, mechanosensitive contraction, food selection, and even the ability to habituate to touch, a simple form of learning usually seen in higher organisms [4]. While early microsurgical approaches demonstrated a startling array of regenerative and morphogenetic processes in this single-celled organism, Stentor was never developed as a molecular model system. We report the sequencing of the Stentor coeruleus macronuclear genome and reveal key features of the genome. First, we find that Stentor uses the standard genetic code, suggesting that ciliate-specific genetic codes arose after Stentor branched from other ciliates. We also discover that ploidy correlates with Stentor's cell size. Finally, in the Stentor genome, we discover the smallest spliceosomal introns reported for any species. The sequenced genome opens the door to molecular analysis of single-cell regeneration in Stentor.

Published
2017

153. COVID-19 - O VÍRUS QUE MOVIMENTOU A CIÊNCIA - VOLUME 1

Author

Almeida, Priscilla Dantas, primary, Araújo, Telma Maria Evangelista de, additional, Brandão, Socorro Adriane de S Meneses, additional, SENA, INARA VIVIANE DE OLIVEIRA, additional, Rodrigues, Érica De Alencar, additional, COSTA, JOELMA MARIA, additional, FRONTEIRA, INÊS, additional, CARDOSO, JONAS ALVES, additional, MELO, EUGÊNIO BARBOSA DE, additional, ALMEIDA, MALENA GONÇALVES, additional, Oliveira, Amanda de Sousa, additional, Silva, Brenda Gonçalves da, additional, Amaro, Cristiane Pereira da Silva, additional, Sousa, Eugenia Gabrielly Alves, additional, Oliveira, Maria Luzia Borges de, additional, Sousa, Rosiane Almeida, additional, Almeida, Sabrina Gomes, additional, FALAVINA, LARISSA PEREIRA, additional, LENTSKC, MAICON HENRIQUE, additional, BARATIERI, TATIANE, additional, PITILIN, ERICA DE BRITO, additional, SANGATELI, CARINE TELES, additional, FUJIMORI, ELIZABETH, additional, Souza, Victor Vinícius da Cruz, additional, Vicentini, Helene Dantas Lima, additional, Mesquita, Leticia de Paula, additional, Sandes, Thayssa Souza, additional, Oliveira, Giovanna Borba, additional, GALDINO, NAYARA DA SILVA, additional, Peixoto, Lucas Cunha, additional, Nascimento, Isabella Moraes do, additional, Melo, Raiana Rodrigues Costa, additional, Abrantes, Maely Moreira de, additional, Gadelha, Lara Rachel Palmeira de Araújo, additional, Silva, Laura Queiroz, additional, Moura, Maria Júlia Costa Pinheiro de, additional, Leandro, Rhévia Mara de Figueiredo, additional, Silva, Thalita de Sá Lira Braga e, additional, Maia, Vivian Maria, additional, Silva, Cleyton Cézar Souto, additional, Menezes, João Daniel de Souza, additional, Mota, Maria Eduarda Dóro, additional, Brandão, Vânia Zaqueu, additional, Ribas, João Luiz Coelho, additional, BARAN, BRUNA APARECIDA, additional, Cunha, Ana Clara Lemos Andrade, additional, Leitão, Rhayssa Vasconcelos, additional, Moura, Scarlat Marjory de Oliveira, additional, FONTOURA, MURILO BARBOZA, additional, FONTOURA, MAÍZA BARBOZA, additional, Iúdice, Tirça Naiara da Silva, additional, Carvalho, Adalberto Cerqueira de, additional, Pereira, Bruno Alberto Falcão, additional, Vieira, Arthemis Soares, additional, Belota, Luiz Henrique Abreu, additional, TELES, SAMUEL GOMES DA SILVA, additional, CASTRO, MARIA CECÍLIA SIMÕES RISCADO DE, additional, DUTRA, SABRINA NOGUEIRA, additional, SANTOS, LÍDIA MÁRCIA SILVA, additional, MORAES, BRUNA DE MOURA, additional, INNOCENTE, MARIA LAURA BRUNELLI, additional, Brito, Patrícia Leite, additional, Rocha, Carolina Luzia Barcelos, additional, Melo, Pedro Resgalla Guimarães de, additional, Faria, Thiago Gonçalves, additional, PEREIRA, JULIANA TOMÉ, additional, Santos, Anna Clara Oliveira, additional, Gomes, Mariana Santos, additional, Morais, Savanna Almeida De, additional, Alves, Jessica Elen Martins, additional, Zica, Mariana Barbosa, additional, Santos, Daniel Spósito, additional, Oliveira, Cecília Soares de, additional, Silva, Ana Cláudia Zuba da, additional, Ornelas, Maria Elisa Souza, additional, Passos, Jessyka Cardoso dos, additional, Teixeira, João Fleury, additional, Rodrigues, Emilly Bruna Soares, additional, Pereira, Breno Magno Gomes, additional, Alves, Felipe Giordano Matos Menezes, additional, Lucena, Gabriel Albuquerque de, additional, Martins, Helman Fernando Paraguay, additional, Carneiro, Júlia Helena Faustino, additional, Silva, Luiz Eduardo Gondim, additional, Fialho, Nathalia Maria Menezes, additional, Viana, Renan Baracuhy Cruz, additional, Wanderley, Saulo, additional, Lacerda, Valdécio Vasconcelos, additional, Marques, Vanessa Julinda Ribeiro Coutinho, additional, ROCHA, ANDRÉ SOUSA, additional, LIMA, VERINEIDA SOUSA, additional, SOUSA, VITÓRIA TALYA DOS SANTOS, additional, RIBEIRO, ANA CARLA NOBRE, additional, DAMASCENO, MONIK CAVALCANTE, additional, SOUSA, ZILDENILSON DA SILVA, additional, ALVES, CHARLES PHILLIPE DE LUCENA, additional, Almeida, Rafaella Farias da Franca, additional, Ferreira, Amanda Emanuela Machado, additional, MATOS, Lucas Vasconcelos da Silva, additional, Ramos, Carlos Antônio Mariz, additional, Torres, Matheus Coelho, additional, Toni, Leonardo Pereira, additional, Bianca, Pedro Arthur Gonçalves de Medeiros Dela, additional, Queiroz, Camila Jales Lima de, additional, Medeiros, Ewerton Freitas de, additional, Castro, Luana Fernandes Da Silva Oliveira, additional, Costa, Maria Júlia Ribeiro da, additional, Santos, Geovanna Godinho, additional, Fernandes, Fernanda Rodrigues Mangabeira, additional, Geronasso, Vitoria Fossari, additional, Costa, Giovanna de Carvalho Meneses, additional, Pitanga, Lorena Sipauba, additional, Trajano, João Gualda Garrido, additional, Caselato, Maria Letícia Lopes Mol, additional, Kreitchmann, Péres, additional, Pedro, Caroline de Oliveira, additional, Goes, Atena Saito, additional, Silva, Amanda Lazaro e, additional, Marti, Giovanna Chiavegatti de Castro Fagan, additional, Castelli, Gustavo Pereira Junqueira, additional, Ivanaga, Hendrick Yuji, additional, Endo, Hugo Emérico Yutaka, additional, Santos, Isabela Cristina Moreira, additional, Melo, Maria Júlia P, additional, Dias, Maria Luisa Alexandrino, additional, SILVA, BARBARA BEATRIZ LIRA DA, additional, ALVES, ANA KLARA RODRIGUES, additional, PEREIRA, RAQUEL DE BRITO, additional, ALVES, ANA KAMILA RODRIGUES, additional, NOGUEIRA, FÁBIO DIAS, additional, RODRIGUES, RICARDO VIEIRA BEZERRA LUZ, additional, RODRIGUES, SANDRA LUIZA GOUVÊA, additional, SANTO, JALES GOMES ESPÍRITO, additional, NOGUEIRA, FLÁVIA DIAS, additional, ALVES, ANA KARLA RODRIGUES, additional, Reiff, Laura Magalhães, additional, Reiff, Cláudio de Castro, additional, Hespanhol, Cecília Barra de Oliveira, additional, Silveira, Sophia Calábria da, additional, Detogni, Giovanna, additional, Moreira, Fernanda Franklin Pedroso, additional, Vieira, Juliana Domith de Oliveira, additional, Leite, Marcela Goreske, additional, Figueiredo, Pollyanny Lilian, additional, Lima, Amilto Mendes, additional, Andrade, Matheus Gomes, additional, Siqueira, Nágela Bezerra, additional, Pereira, Lurdiane Gabriel, additional, Pereira, Maria Larysse Muniz, additional, Camelo, Paula Alves, additional, Alves, Mikaelly Teixeira, additional, Silva, Felicia Maria Rodrigues da, additional, Sousa, José Fernando Martins, additional, Melo, Dilene Fontinele Catunda, additional, Cunha, Maria da Conceição dos Santos Oliveira, additional, CORREIA, ELISA DE CASTRO, additional, CASTRO, ANA BEATRIZ SAMPAIO PINTO DE, additional, LIMA, TATIANA MONTANDON LASSI LOPES, additional, SILVA, HELLEN CAROLINA BRANDÃO, additional, BICALHO, GABRIELA BOLLER, additional, BERNIS, EDUARDA HERINGER, additional, BARBOSA, JOÃO ARTHUR RODRIGUES, additional, AZEVEDO, INGRIDY MARIA DINIZ MELO, additional, BICHARA, MATHEUS MIRANDA, additional, OLIVEIRA, RAYANA VIEGAS, additional, Albuquerque, Lidiane Pereira de, additional, Rêgo, Otávio Augusto Nunes do, additional, Sousa, Sarah Batista de, additional, Araújo, Regina Maria Sousa de, additional, Araújo, Vitória Gabriele Barros de, additional, Sales, Liandra Vírginia de Sousa Coêlho, additional, Silva, Bárbara Leite da, additional, Barrinha, Maria Clara Falcão, additional, Silva, Verônica Letícia Magalhães da, additional, Almeida, Rumana de França, additional, Melo, Ingrid da Silva, additional, Rocha, Amanda Virginia Teles, additional, Moraes, Ramires dos Santos, additional, Alves, Nágila Silva, additional, CARVALHO, NAYARA ALMEIDA, additional, OLIVEIRA, THAYENE BARBOSA DE, additional, QUISTE, SARAH SOUZA, additional, TEIXEIRA, BEATRIZ NASSER, additional, CUNHA, JORDANA CARNEIRO RODRIGUES DA, additional, OLIVEIRA, MORGANA ROCHA COUTINHO DE, additional, MITTELMANN, IARA CAROLINI, additional, SANTOS, ANDRÉ REHBEIN, additional, SALES, PRISCILA MAGALHÃES ESTEVES DE, additional, BORGES, RAQUEL CAMARGOS, additional, Mafra, Caio Souza Lima, additional, Chaimowicz, Beatriz de Faria, additional, Menezes, Bruno Petrocchi Vieira de, additional, Villela, Ana Carolina Wegmann, additional, Coutinho, Camila Hostalacio Duarte, additional, Santos, Clara Chagas Barbosa, additional, Pimenta, Clara Rubião, additional, Silva, Daniela Diniz Martins da, additional, Fonseca, David Bastos Vieira da, additional, Valadares, Nara Maria Meira, additional, FRANCO, DANIELLA RIBAS, additional, MORILA, MARIANA CRISTINA GOMES, additional, FONSECA, LUCAS AUGUSTO NIESS SOARES, additional, MESQUITA, FRANCIELLE BIANCA MOREIRA DE, additional, LESSA, RUAN TEIXEIRA, additional, MORATO, PEDRO CÉSAR, additional, VIDAL, DAVI MARTINS, additional, SOUZA, DANILO JOSÉ MARTINS DE, additional, Ferreira, Tayná Beato, additional, Silva, Vitória Leite, additional, Batista, Galileu Bitencourt, additional, Mendes, Nathália Barbosa do Espírito Santo, additional, Faria, Thaís Guimarães de, additional, Pereira, Gabriella Reis Granata, additional, Pizani, Izabella Alves, additional, Ferreira, Julia Caramatti, additional, Almeida, Luiza Figueiredo Ribeiro, additional, Gama, Henrique Valladão Pires, additional, Passos, Ovídio Neves Berquó de, additional, Rocha, João Gabriel Seixo de Britto, additional, Lima, Laura Araújo de, additional, Trigueiro, Gustavo Machado, additional, Fernandes, Caroline Ferreira, additional, Uesugi, Juliana Hiromi Emin, additional, Silva, Jonatan Carlos Cardoso da, additional, Trindade, Eliane Leite da, additional, SOUZA, CAIO FERREIRA FILGUEIRAS DE, additional, REIS, BRUNA ELISA SANTIAGO, additional, CASTRO, CÁSSIA LUANA DE FARIA, additional, NASCIMENTO, EDUARDA FARIA DO, additional, FACCIO, CAROLINA BOHN, additional, MANSUR, HELENA MARTINS FERREIRA, additional, MANSUR, ISABELA MARTINS FERREIRA, additional, FULBER, JADE GUIMARÃES, additional, FERRAZ, JOÃO PEDRO KREMER, additional, BINKOWSKI, LUDMILA LIMPIAS TERRAZAS, additional, VAZ, VINICIUS CATTO, additional, CARUSO, FERNANDA BORSATTO, additional, Silva, Marcos Paulo Da, additional, Lourenço, Heitor Fernandes, additional, Neves, Gabriela Gonçalves Saraiva, additional, Amorim, Davi Candido, additional, Gomes, Antônio Caio Carvalho, additional, LIMA, JOSÉ AILTON GOMES DE, additional, Silva, Nathália Paula Da, additional, Sousa, Zildenilson da Silva, additional, Silva, Thaylon Menezes Ferreira da, additional, Pereira, João Ricardo Gomes, additional, Rodrigues, Shara Teixeira Belarmino, additional, Freitas, Marcelo Matos de, additional, Rodrigues, José Auberlanio Lima, additional, Sousa, Jady Júlia Patrício de, additional, Cipriano, Antônio Marcos Adriano, additional, Silva, Natália Viviane de Freitas da, additional, Rocha, André Sousa, additional, Nóbrega, Ianny Costa Moura de Paiva, additional, Souza, Khívio Dantas de Assis, additional, Araújo, Roberta Letícia Paiva de, additional, Ribeiro, Brenda de Souza, additional, BEZERRA, MICHELLY FERNANDES, additional, Silva, Letícia Figueirôa, additional, RABELO, MARINA ARAÚJO, additional, SANTOS, AMANDA SIMÕES, additional, GONÇALVES, ANA PAULA MENDONÇA, additional, FREIRE, MARINA VILLELA, additional, RODRIGUES, PEDRO AUGUSTO SCHREIER, additional, SILVA, JOSÉ DIAS, additional, NORONHA, NATHALIA COSTA MACEDO, additional, PASSOS, ANDRÉ LUÍS FERREIRA DE SOUZA, additional, CRUZ, ISABELLE SILVA MELO DA, additional, RAMOS, MARIA LETÍCIA CARVALHO DA CRUZ, additional, SOARES, MARIANA DA COSTA CAMPOS, additional, LESSA, VERÔNICA VIRGÍNIA SANTOS, additional, MAYNARD, LUANA GODINHO, additional, GUIMARAES, THIAGO ALBUQUERQUE DE MENEZES, additional, ROCHA, GABRIEL, additional, CHATEAUBRIAND, GUILHERME TEIXEIRA, additional, LACERDA, JULIA SCOTTI GONÇALVES, additional, FERREIRA, PEDRO CHAVES, additional, LEITE, PITHER PAUL SILVA, additional, SOUZA, RAYNER GUILHERME DE, additional, PIRES, RICARDO LAGE GUERRA LOTT, additional, GONÇALVES, SAMUEL CRISTOVAO LOPES, additional, PITANGUI, SERVULO WALLNER, additional, SARAIVA, JAYANE MENDES, additional, CARVALHO, LUMA MATOS, additional, SOUSA, LETÍCIA LUDWIG, additional, CAIXETA, LETÍCIA MARIA, additional, MARQUES, SÍLVIA FERNANDA PEREIRA, additional, MARQUES, IZE AMANDA PEREIRA, additional, SOUSA, KESSIA VITORIA SILVA, additional, MACHADO, MARÍLLIA DE FREITAS, additional, CAMPOS, BRUNA TAFURI LOBATO, additional, COELHO, BÁRBARA GISELLY ZANON, additional, BRANDÃO, TOMÁS ELAWAR SILVIANO, additional, VILAÇA, GABRIELLE SILVEIRA, additional, ASSIS, VIVIAN COSTA MORAIS DE, additional, SANTOS, JEHOVAHNNA ANTTONIONI, additional, SPÓSITO, LAVÍNIA ARRUDA, additional, Pinheiro, Elisama Pereira, additional, MORAL, LORENA RAMOS, additional, PONTES, KAIO HENRIQUE OLIVEIRA, additional, Batista, Matheus Neres, additional, S, Joel A, additional, OLIVEIRA, MARCELA MARINHO DE, additional, Veloso, Eliana A N, additional, OLIVEIRA, CAIO LIMA, additional, LIMA, LUCAS EMMANUEL RODRIGUES DE, additional, LIMA, LUANA BEATRIZ RIBEIRO, additional, SOARES, ANA CATARINA TOMAZ, additional, BARDOTTI, ARIANNA, additional, SANTOS, ALICE FREIRE DOS, additional, SILVA, BIANCA DO NASCIMENTO, additional, ANDRADE, LARYSSA ELLEN MOURA DE, additional, ARNEZ, TICIANA MEDEIROS DE SABOIA, additional, ALMEIDA, LAURA F DE, additional, MOURÃO, ANA C S, additional, WERNECK, BEATRIZ M, additional, DIAS, DIEGO B, additional, MATTA, GUSTAVO P, additional, REIS, IOLY G DOS, additional, PRETA, MARIA P S C, additional, JACOMETTI, VICTOR, additional, CORREA, VICTOR L F, additional, REZENDE, VITORIA F, additional, Oliveira, Halley Ferraro, additional, CARRANZA, BRENDA LOUISE PRADO, additional, SILVEIRA, FERNANDA BEATRIZ SANTOS, additional, GOMES, ZULEIDE BARROS LUNA, additional, CARVALHO, KETTINY FERNANDA N DE, additional, AGUIAR, GUSTAVO ALVES, additional, ANTUNES, SABRINA BARRETO, additional, MONTE, KAHENA MONTEIRO ALMEIDA, additional, SANTANA, BÁRBARA REIS DE, additional, Souza, Júllia Beatriz Araujo, additional, Santos, João Marcos da Cunha, additional, Coelho, Larissa Maria Prado, additional, Rebouças, Natália Quiroga, additional, ANDRADE, PEDRO VÍTOR PASSOS DA COSTA, additional, Araújo, Wesley Vinicius Tenório de, additional, OLIVEIRA, HALLEY FERRARO, additional, Duz, Bruna, additional, Curi, Julio Soares, additional, FORTUNA, TIAGO, additional, ROVERSI, CAROLINE DE OLIVEIRA, additional, LOPES, LUIZ ROBERTO, additional, Nascimento, Isabella Moraes, additional, SCHWENING, SARAH SOUZA QUISTE, additional, and Paiva, Ianny Costa Moura de, additional

Published
2021
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156. Ein neuer Sensoransatz für die Feinpositionierung eines O-Bus Stromabnehmers

Author

Hochschule für Technik, Wirtschaft und Kultur Leipzig, Kupper, Stefan, Fröhlich, Stefan, Reiff-Stephan, Jörg, Hochschule für Technik, Wirtschaft und Kultur Leipzig, Kupper, Stefan, Fröhlich, Stefan, and Reiff-Stephan, Jörg

Abstract

Urbane Mobilität insbesondere der innerstädtischen Personentransport wird auch zukünftig ein besonderes Augenmerk unter dem Eindruck nachhaltiger Nutzung von Energiesystemen haben. Hierbei besitzt der öffentliche Personennahverkehr(ÖPNV) ein großes Potential zur großskaligen Minderung des Kohlendioxid ausstoßes. Ein sehr wichtiges Konzept hierbei ist der Oberleitungsbus der ganz analog zu einer Straßenbahn über eine Oberleitung fahrbahnbegleitend mit Strom versorgt wird. Da der Bus naturgemäß nicht schienengebunden fährt und somit ein gewisses Maß an Positionsungenauigkeit besitzt, ist das Eindrahten an die Oberleitung allerdings erschwert. In dieser Arbeit präsentieren wir einen Regelungsansatz basierend auf einer neuartigen Sensorkonfiguration, der das automatische Eindrahten eines Stromabnehmers auf einem Bus ermöglichen kann.

Published
2024

157. Industrie 5.0 Lernumgebung am Beispiel der Wildauer Smart Production

Author

Hochschule für Technik, Wirtschaft und Kultur Leipzig, Günther, Norman, Prell, Bastian, van de Sand, Ron, Reiff-Stephan, Jörg, Hochschule für Technik, Wirtschaft und Kultur Leipzig, Günther, Norman, Prell, Bastian, van de Sand, Ron, and Reiff-Stephan, Jörg

Abstract

Die Industrie 5.0 fordert neue Lernansätze und zeitgleich auch passende Lernumgebungen. Parallel müssen diese neben den didaktischen Herausforderungen auch den Transfer- und Übertragungsgedanken auf die industriellen Anwendungen gerecht werden. Durch die täglich steigende Anzahl vielfältiger KI-Tools insbesondere textgenerierenden Tools, braucht es Systeme mit einem breiten Anwendungsbereich. Im Rahmen des vorliegenden Beitrags geben die Autoren einen Einblick in die Wildauer Smart Production, welche den transdisziplinären Gedanken von Lern- und Transferumgebungen Rechnung trägt, Möglichkeiten der Gestaltung komplexer Produktionssysteme widerspiegelt, die Integration menschzentrierter Ansätze ermöglicht und als Forschungsumgebung eingesetzt wird.

Published
2024

159. The extinct marine megafauna of the Phanerozoic

Author

Pimiento, Catalina; https://orcid.org/0000-0002-5320-7246, Kocáková, Kristína; https://orcid.org/0000-0002-2270-8435, Mathes, Gregor H; https://orcid.org/0000-0002-2788-1173, Argyriou, Thodoris; https://orcid.org/0000-0002-2036-5088, Cadena, Edwin-Alberto; https://orcid.org/0000-0003-3038-567X, Cooper, Jack A; https://orcid.org/0000-0003-2252-4983, Cortés, Dirley; https://orcid.org/0000-0001-9409-7429, Field, Daniel J; https://orcid.org/0000-0002-1786-0352, Klug, Christian; https://orcid.org/0000-0002-4099-7453, Scheyer, Torsten M; https://orcid.org/0000-0002-6301-8983, Valenzuela-Toro, Ana M; https://orcid.org/0000-0003-1497-364X, Buess, Timon, Günter, Meike, Gardiner, Amanda M; https://orcid.org/0009-0002-5518-1235, Hatt, Pascale; https://orcid.org/0009-0009-6088-2555, Holdener, Geraldine, Jacober, Giulia, Kobelt, Sabrina, Masseraz, Sheldon, Mehli, Ian, Reiff, Sarah, Rigendinger, Eva, Ruckstuhl, Mimo, Schneider, Santana, Seige, Clarissa, Senn, Nathalie, Staccoli, Valeria, Baumann, Jessica, Flüeler, Livio, Guevara, Lino J, et al, Pimiento, Catalina; https://orcid.org/0000-0002-5320-7246, Kocáková, Kristína; https://orcid.org/0000-0002-2270-8435, Mathes, Gregor H; https://orcid.org/0000-0002-2788-1173, Argyriou, Thodoris; https://orcid.org/0000-0002-2036-5088, Cadena, Edwin-Alberto; https://orcid.org/0000-0003-3038-567X, Cooper, Jack A; https://orcid.org/0000-0003-2252-4983, Cortés, Dirley; https://orcid.org/0000-0001-9409-7429, Field, Daniel J; https://orcid.org/0000-0002-1786-0352, Klug, Christian; https://orcid.org/0000-0002-4099-7453, Scheyer, Torsten M; https://orcid.org/0000-0002-6301-8983, Valenzuela-Toro, Ana M; https://orcid.org/0000-0003-1497-364X, Buess, Timon, Günter, Meike, Gardiner, Amanda M; https://orcid.org/0009-0002-5518-1235, Hatt, Pascale; https://orcid.org/0009-0009-6088-2555, Holdener, Geraldine, Jacober, Giulia, Kobelt, Sabrina, Masseraz, Sheldon, Mehli, Ian, Reiff, Sarah, Rigendinger, Eva, Ruckstuhl, Mimo, Schneider, Santana, Seige, Clarissa, Senn, Nathalie, Staccoli, Valeria, Baumann, Jessica, Flüeler, Livio, Guevara, Lino J, and et al

Abstract

The modern marine megafauna is known to play important ecological roles and includes many charismatic species that have drawn the attention of both the scientific community and the public. However, the extinct marine megafauna has never been assessed as a whole, nor has it been defined in deep time. Here, we review the literature to define and list the species that constitute the extinct marine megafauna, and to explore biological and ecological patterns throughout the Phanerozoic. We propose a size cut-off of 1 m of length to define the extinct marine megafauna. Based on this definition, we list 706 taxa belonging to eight main groups. We found that the extinct marine megafauna was conspicuous over the Phanerozoic and ubiquitous across all geological eras and periods, with the Mesozoic, especially the Cretaceous, having the greatest number of taxa. Marine reptiles include the largest size recorded (21 m; Shonisaurus sikanniensis) and contain the highest number of extinct marine megafaunal taxa. This contrasts with today’s assemblage, where marine animals achieve sizes of >30 m. The extinct marine megafaunal taxa were found to be well-represented in the Paleobiology Database, but not better sampled than their smaller counterparts. Among the extinct marine megafauna, there appears to be an overall increase in body size through time. Most extinct megafaunal taxa were inferred to be macropredators preferentially living in coastal environments. Across the Phanerozoic, megafaunal species had similar extinction risks as smaller species, in stark contrast to modern oceans where the large species are most affected by human perturbations. Our work represents a first step towards a better understanding of the marine megafauna that lived in the geological past. However, more work is required to expand our list of taxa and their traits so that we can obtain a more complete picture of their ecology and evolution.

Published
2024

160. Hybrid project management – a systematic literature review

Author

Janine Reiff and Dennis Schlegel

Subjects
hybrid project management, agile project management, traditional project management, project approaches, project management methodologies, Management. Industrial management, HD28-70
Abstract

Hybrid project management is an approach that combines traditional and agile project management techniques. The goal is to benefit from the strengths of each approach, and, at the same time avoid the weaknesses. However, due to the variety of hybrid methodologies that have been presented in the meantime, it is not easy to understand the differences or similarities of the methodologies, as well as, the advantages or disadvantages of the hybrid approach in general. Additionally, there is only fragmented knowledge about prerequisites and success factors for successfully implementing hybrid project management in organizations. Hence, the aim of this study is to provide a structured overview of the current state of research regarding the topic. To address this aim, we have conducted a systematic literature review focusing on a set of specific research questions. As a result, four different hybrid methodologies are discussed, as well as, the definition, benefits, challenges, suitability and prerequisites of hybrid project management. Our study contributes to knowledge by synthesizing and structuring prior work in this growing area of research, which serves as a basis for purposeful and targeted research in the future.

Published
2022
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161. I CARE: Development and Evaluation of a Campus Gatekeeper Training Program for Mental Health Promotion and Suicide Prevention

Author

Reiff, Marian, Kumar, Meeta, Bvunzawabaya, Batsirai, Madabhushi, Soumya, Spiegel, Alaina, Bolnick, Benjamin, and Magen, Eran

Abstract

Addressing the need for suicide prevention on campus, I CARE training, developed and facilitated by counseling center clinicians, trains students, staff, and faculty to provide support to students experiencing distress or mental health problems. We assessed its impact using a mixed-methods approach. Quantitative analyses demonstrated significant increases in knowledge of intervention skills and readiness to intervene from pretraining to posttraining. Knowledge and readiness remained significantly higher than preworkshop for the entire follow-up evaluation period, extending 15 months posttraining. Qualitative analyses revealed the value of experiential activities and emotional processing in increasing participants' comfort and preparedness to intervene in challenging situations.

Published
2019
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163. Saúde: do ensino à pesquisa vol. 3

Author

ALVES, Ariany Vidal, primary, ALMEIDA, Mariana Silva, additional, MAGALHÃES, Maria Helena Marques, additional, LIMA, Vitória Costa, additional, MARQUES, Gabriela Fernandes Oliveira, additional, Monteiro, Marina Osias Didier de Azevedo Melo, additional, QUEIROZ, Larissa Vasconcelos, additional, RODRIGUES, Kelvin de Souza, additional, Ralph, Gisela Cavalcanti de Andrade, additional, ARAÚJO-FILHO, Jorge Luiz Silva, additional, Souza, Álvaro Zanon de, additional, Ramos, Giselle Huebra, additional, Silva, Isadora Moura da, additional, Amorim, Júlia Vieira, additional, Silva Neto, Rivadávia Fernandes da, additional, Ferraz, Sarah Silva, additional, Canato, Gláucia Maria, additional, Torres, Vitória da Silva, additional, Costa, Maria Antônia Ramos, additional, Pesce, Giovanna Brichi, additional, Spigolon, Dandara Novakowski, additional, Varela, Patrícia Louise Rodrigues, additional, Maués, Josyléa Vieira Monteiro, additional, Rodrigues, Larissa Siqueira, additional, Marques, Myleide dos Santos, additional, Lima, Thabita Marques, additional, Carneiro, Carlos Alex de Menezes, additional, Couto, Mayra Hermina Simões Hamad Farias do, additional, Rosas, Maria Carolina Loureiro, additional, Fontanezzi, Mariana Nicoli Pereira, additional, Correa, Beathriz Admoni, additional, Lima, Yago Gome dos Reis, additional, Bartos, Mariana Scaff Haddad, additional, Santos, Larissa Sandy Ferreira, additional, Viana, Laura Santos, additional, Moura, Lívia Pedrosa, additional, Emerich, Bianca Tavares, additional, Paiva, Lara Alves, additional, Martins, Karina Gomes, additional, Grapiuna, Raquel Sena Pontes, additional, Coelho, Thays Carvalho Caldeira, additional, Silva, Hemerson Garcia de Oliveira, additional, Lima, Francisco Samuel Torquato, additional, Oliveira, Maria Eduarda Alves, additional, Moura, Ozeny de Sousa, additional, Abreu, Kaylane Moreira Lima de, additional, ASSIS, Elisangela Vilar de, additional, Porto, Joana D Arc Silvério, additional, Costa Neto, Sebastião Benício da, additional, Sousa, Ivone Félix de, additional, Inácio, Geovanna Porto, additional, Rassi, Salvador, additional, Oliveira, Isadora de, additional, Klein, Bárbara Diel, additional, Ortiz, Gabrielle Schneider, additional, Saraiva, Ian Braga, additional, Reolão, José Basileu Caon, additional, Santos, Heloisa Griese Luciano dos, additional, Santos, João Guilherme Moura L. Dos, additional, Melo, Rodolfo Matias de, additional, Pereira, Suyane da Silva Couto, additional, Nunes, Bruno Eduardo Morais, additional, Watanabe, Letícia Yumi Fukuda, additional, Montanhim, Carolina de Lima, additional, Carvalho, Maressa Maziero de, additional, Carvalho, Mateus Maziero de, additional, Luciano, Ana Luíza Fleury, additional, Vilela, Ana Beatriz Vieira, additional, Resplande, Caroline Almeida, additional, Xavier, João Victor Alves, additional, Bastos, Gabriela Santos, additional, Sousa, Ana Lúcia Osório Maroccolo de, additional, Sanchez, Caroline Grisoni, additional, Malagutti, Bianca Cocato, additional, Fini, Sabrina Bertanha, additional, Primo, Ketlyn Gabriele, additional, Paula, Ramiris Luisa De, additional, Alves, Carlos Eduardo Fonseca, additional, Lopes, Camilla Ozanan Moreira, additional, Sampaio, Victor Almeida, additional, Medeiros, Mário Luan Silva de, additional, Loss, Lairane Bridi, additional, Bridi, Júlio César, additional, Loss, Carolainy Frohlich, additional, Francischetto, Lana, additional, Rossi, Luiz Felipe Caetano Moraes, additional, Júnio, José Augusto Martins Lemos, additional, Soares, Beatriz Rayanne Barbosa, additional, TORRES, Lucas Cruz, additional, FERREIRA, Mateus Andrade, additional, Abreu, João Victtor dos Santos, additional, Ferreira, Bruna Monara Rocha, additional, Almeida, Ênio Henrique Cavalcante, additional, Andrade, Raiane Antônia de, additional, Santos, Maria Beatriz Silva dos, additional, Rangel, Larissa Sousa, additional, Alves, Kamila Maria de Jesus da Silva, additional, Campos, Álvaro Luiz Fonseca, additional, Lovatti, Ricardo Rodrigues, additional, Pereira, Lorem Stefany da Silva, additional, Siqueira, Victória Cristina dos Anjos, additional, Cândido, João Flávio Nepomuceno, additional, Rhis, Guilherme, additional, Vasconcelos, Ingrid Fátima Martins, additional, Reiff, Laura Magalhães, additional, Vasconcelos, Estéfane Lorraine Martins, additional, Costa, Ronaldo Rodrigues da, additional, Romeiro, Pedro Henrique Cardieri, additional, Pimenta, Rafaela Brito Cardoso Lamarca, additional, Diniz, Lucas Rodrigues, additional, Kataoka, Tales Dalfior, additional, Nolasco, Dayanne Leite, additional, Silva, Julia de Paiva Rodrigues da, additional, Martins, José Tadeu Carvalho, additional, Salgueiro, Suele Moreira de Oliveira, additional, Cerqueira, Maiara Silva Santos de, additional, Martins, Caroline Aquino, additional, Oliveira, Iraci Pires de, additional, Barreto, Amanda dos Reis, additional, Santos, Josely Bruce dos, additional, Melo, Talita Monteiro Rios, additional, Brito, Ana Vitória de Oliveira, additional, Santos, Monique de Jesus, additional, Moura, Pedro Afonso de Paula de Souza, additional, Moura, Ioli Menezes Vasconcelos, additional, Gomes, Luis H A, additional, Tenório, Luís Cunha de Souza, additional, Menezes, Vinícius Albuquerque de, additional, Azevedo, Thayanne Gusmão de, additional, SILVA NETO, ALVARO BULHÕES DA, additional, Andrade, Clara Pego de, additional, Costa, Grace de Assis, additional, Costa, Lorena Cristina Peixoto, additional, Dutra, Mariana Carolina Carmo Luiz da Silva, additional, Pereira, Tatiane Maria de Alvarenga, additional, Netto, Ernesto Machado Nunes, additional, Oliveira, Carolina Feitosa de, additional, Costa, Bruna Sampaio Lopes, additional, Escorel, Lívia Menezes, additional, Alves, Ianara Fabiana Ramalho Dias, additional, Costa, Iara Oliveira, additional, Aguiar, Michelle Salles Barros de, additional, Aguiar, Michelle Sales Barros de, additional, Nishi, Julia Faustino, additional, Laureano, Kristen Guilarducci, additional, Silva, Isabela Lobo da, additional, Camara, João Pedro Carrijo Cunha, additional, Luiz, Victória Carolinne Alves, additional, Palmerston, Marina Dumond, additional, Rezende, Juliana Aparecida, additional, Campos, Matheus Damas, additional, Aguiar, Nathalia Marra, additional, Torres, Fabrizzio German Fernandini, additional, Moreira, Larissa Andrade, additional, Campos, Jessica Rodrigues Nogueira, additional, Wercelens, Victor Oliveira, additional, Freitas, Beatriz Pintaud de, additional, Santos, Bruna Martins dos, additional, Santos, Isabella Tronconi, additional, Duque, Anderson Silveira, additional, Oliveira, Vinícius Carvalho de, additional, Moreira, Larissa Oliveira, additional, Vilela, Luciano Rezende, additional, A Neto, Ernann T, additional, Carvalho, Ana C S, additional, Vieira, Matheus Emannuel Santos, additional, Sousa, Saulo Batista de, additional, Magalhães Junior, Darlan Medeiros de, additional, Silva Neto, Álvaro Bulhões da, additional, Pacheco, Bruna Benetti, additional, Lopes, Gabriel Ferreira, additional, Miglioli, João Vitor Brito, additional, Gomes, Natália Cristina Silva, additional, Arruda, Evilanna Lima, additional, Matos, Erick Everton Batista, additional, Nascimento, Clayton Santos, additional, Martins, Mateus Andrade, additional, Lopes, Tiago de Albuquerque, additional, Leite, Priscila Oliveira, additional, Souza, Natália Melo, additional, Silva, Kamila Maestro da, additional, Borges, Lucas do Nascimento, additional, Ferreira, Miriã Vieira dos Santos, additional, Ornelas, Sarah Campos, additional, Vargas, Laura Lima, additional, Matias Júnior, Alceu Rosa, additional, Silva, Kaline Lopes da, additional, Oliveira, Vinicius Abdias Santos de, additional, Alexandria, Walleria Rodrigues de, additional, Oliveira, Manuela de Melo, additional, Assis, Elisangela Vilar de, additional, Silva, Ana Clara Camillato e, additional, Azevedo, Ana Luiza Calabrez Falcão, additional, Sarmento, Bruna Chárin da Silva, additional, Viana, Kassyo Kerlley Silva, additional, Gali, Matheus Cadena Andorrá, additional, SOUZA, Sabrina Stefany da Silva, additional, Bezerra, Israel Alves, additional, Souza, Amanda Araújo, additional, Sousa, Renato de Lima, additional, Barros, Vivyan Raffaelly Ramos de, additional, Brandão Filho, Mário Ronalsa, additional, Rizzatto, Gabriel Dill, additional, Borges, Daniela Teixeira, additional, Bernardino, Clara Lucas, additional, and Lima, Nathalia Machado de, additional

Published
2021
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166. Scope of services provided to childhood cancer patients by the Brazilian Pediatric Palliative Care Network.

Author

Luiz Ferreira, Esther Angélica, Sobrinho Valete, Cristina Ortiz, Maria de Macedo Barbosa, Silvia, de Araujo Costa, Graziela, Carmona Molinari, Poliana Cristina, Pugliese de Castro, Ana Cristina, Brasil de Oliveira Iglesias, Simone, Rodrigo Sarracini, Maycon, Bezerra de Menezes Reiff, Rodrigo, Helena Bruno, Cristina, SagrarioGómez-Cantarino, Maria, and María Ullán, Ana

Subjects
PEDIATRIC therapy, PALLIATIVE treatment, CHILDHOOD cancer, CANCER patient care, ONCOLOGY nursing, CANCER patients, MIDDLE class
Abstract

Introduction: Brazil is a developing and an Upper Middle Income, categorized by the World Bank. Therefore, it is a country that needs a special vision for children with oncological diseases who require Pediatric Palliative Care. This study aimed to understand the specificities of services that provide oncology services in comparison to those that do not provide oncological care. Methods: This is a descriptive, cross-sectional, and online survey study. A questionnaire was created by a multidisciplinary group of leaders from the Brazilian Pediatric Palliative Care Network and then the survey was distributed using a snowball strategy. Results: Of the 90 services that answered the questionnaire, 40 (44.4%) attended oncologic patients. The Southeast represented most of the services (57.57%), followed by the Northeast, with 18.89% (17 services), the South with 12.22% (11 services), and the Center West with 8.89% (8 services). No differences were observed in access to opioid prescriptions between the services. It was observed that those services that attended oncologic patients had a tendency to dedicate more time to Pediatric Palliative Care. Discussion: The distribution of services that cover oncology and those that do not, are similar in the different regions of Brazil. In Brazil, there are difficulties in accessing opioids in pediatrics: access to opioid prescriptions without differences revealed that even pediatric oncologists might have difficulty with this prescription, and this should improve. It is concluded that education in Pediatric Palliative Care is the key to improvements in the area. [ABSTRACT FROM AUTHOR]

Published
2024
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167. The liberal conception of free speech and its limits.

Author

Reiff, Mark R.

Abstract

Unfortunately, many people today see the regulation of lies, disinformation, hate speech, and fake news as an infringement of free speech, at least when such speech is ‘political,’ despite the damage that such speech can do. But this very protective attitude toward speech rests on a mistaken understanding of the role of free speech in a liberal society. The right to free speech is based on the liberal value of freedom, and as such can be no broader than freedom itself. And freedom has always been subject to reasonable limits in a liberal society. Indeed, while the principles of toleration and neutrality are often cited as supporting a broad interpretation of the right to free speech, they also tell us that certain limits apply to that right. We need not tolerate speech that encourages intolerance, and while government should be neutral between reasonable conceptions of the good, it need not be neutral between reasonable and unreasonable conceptions. These ideas form the framework of liberal society, and as I shall show, also provide a guide for understanding what kind of speech is protected in a liberal society and what it is not. [ABSTRACT FROM AUTHOR]

Published
2024
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174. Prevalence and significance of serum 14–3-3η in juvenile idiopathic arthritis

Author

Iris Reyhan, Olga S. Zhukov, Robert J. Lagier, Robert F. Bridgforth, Gary J. Williams, Joanna M. Popov, Stanley J. Naides, and Andreas Reiff

Subjects
Juvenile idiopathic arthritis, CCP antibody, Rheumatoid factor, Biomarker, 14–3-3η(eta), Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14–3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody in adult rheumatoid arthritis (RA), and have been associated with more severe phenotype. We investigated the prevalence and clinical significance of serum 14–3-3η in different types of JIA. Methods JIA patients (n = 151) followed by the Pediatric Rheumatology Core at Children’s Hospital of Los Angeles were categorized into 5 groups: polyarticular JIA RF+ (PJIA RF+; n = 39), PJIA RF- (n = 39), psoriatic arthritis (PsA; n = 19), enthesitis-related arthritis (ERA; n = 18), and oligoarticular JIA (OJIA [control group]; n = 36). RF, CCP antibody, and 14–3-3η were measured for all patients. 14–3-3η serum levels > 0.2 ng/mL were considered positive. Disease activity was assessed by the Juvenile Arthritis Disease Activity Score-71 (JADAS-71). Results Elevated 14–3-3η levels were detected in 34/151 (23%) patients, and across all groups tested. Most patients with 14–3-3η had titers ≥4 times above the cutoff value. The majority (22, 65%) of 14–3-3η-positive patients were also positive for RF or CCP antibodies, 16 (47%) were positive for all 3, and 12 (35%) were single-positive for 14–3-3η. The highest prevalence of 14–3-3η was in PJIA RF+ patients (49%), followed by OJIA (22%). Positivity for 14–3-3η was not significantly associated with disease activity or age at diagnosis. Conclusion Serum 14–3-3η can be detected in all forms of JIA tested but appears to be most common in PJIA RF+. 14–3-3η does not appear to correlate with disease activity in JIA.

Published
2021
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175. Distinguishing active pediatric COVID-19 pneumonia from MIS-C

Author

Daniel D. Reiff, Melissa L. Mannion, Nichole Samuy, Paul Scalici, and Randy Q. Cron

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Importance Active pediatric COVID-19 pneumonia and MIS-C are two disease processes requiring rapid diagnosis and different treatment protocols. Objective To distinguish active pediatric COVID-19 pneumonia and MIS-C using presenting signs and symptoms, patient characteristics, and laboratory values. Design Patients diagnosed and hospitalized with active COVID-19 pneumonia or MIS-C at Children’s of Alabama Hospital in Birmingham, AL from April 1 through September 1, 2020 were identified retrospectively. Active COVID-19 and MIS-C cases were defined using diagnostic codes and verified for accuracy using current US Centers for Disease Control case definitions. All clinical notes were reviewed for documentation of COVID-19 pneumonia or MIS-C, and clinical notes and electronic medical records were reviewed for patient demographics, presenting signs and symptoms, prior exposure to or testing for the SARS-CoV-2 virus, laboratory data, imaging, treatment modalities and response to treatment. Findings 111 patients were identified, with 74 classified as mild COVID-19, 8 patients as moderate COVID-19, 8 patients as severe COVID-19, 10 as mild MIS-C and 11 as severe MIS-C. All groups had a male predominance, with Black and Hispanic patients overrepresented as compared to the demographics of Alabama. Most MIS-C patients were healthy at baseline, with most COVID-19 patients having at least one underlying illness. Fever, rash, conjunctivitis, and gastrointestinal symptoms were predominant in the MIS-C population whereas COVID-19 patients presented with predominantly respiratory symptoms. The two groups were similar in duration of symptomatic prodrome and exposure history to the SARS-CoV-2 virus, but MIS-C patients had a longer duration between presentation and exposure history. COVID-19 patients were more likely to have a positive SAR-CoV-2 PCR and to require respiratory support on admission. MIS-C patients had lower sodium levels, higher levels of C-reactive protein, erythrocyte sedimentation rate, d-dimer and procalcitonin. COVID-19 patients had higher lactate dehydrogenase levels on admission. MIS-C patients had coronary artery changes on echocardiography more often than COVID-19 patients. Conclusions and relevance This study is one of the first to directly compare COVID-19 and MIS-C in the pediatric population. The significant differences found between symptoms at presentation, demographics, and laboratory findings will aide health-care providers in distinguishing the two disease entities.

Published
2021
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176. COMPARATIVE ANALYSIS OF CERVICAL SAGITTAL BALANCE WITH RADIOGRAPHS IN DIFFERENT POSTURES

Author

Vania Maria Lima, Guilherme Reiff Toller, and Nilson Mozas Olivares

Subjects
Spine, Postural Balance, Radiography, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935
Abstract

ABSTRACT Objective: To compare the cervical sagittal balance in groups of patients submitted to lateral radiographs of the cervical segment, with the upper limbs in two different positions. Methods: This is a cross-sectional, quantitative, prospective, descriptive study using radiographic analysis of 100 adult individuals, aged between 20 and 70 years. Two lateral radiographs were taken of each patient, one image with the upper limbs crossed over the trunk (flexed elbows) and the other with the upper limbs elevated in front (extended elbows). All patients answered a questionnaire about age, sex, presence of pain in the cervical spine, as well as degree of pain based on the Likert scale. The radiographic parameters evaluated were the COBB angle (Cobb), thoracic inlet angle (TIA), T1 slope, neck tilt and distance from the center of gravity (COG) of the skull to C7 (COG-C7) with the elbows in extension (Ext) and flexion (Flex). A p-value of less than 0.05 was considered a statistically significant difference. Results: Sixty patients were female (60%) and forty were male (40%). The data analysis obtained showed statistical significance in Cobb Flex vs. Cobb Ext (p = 0.000), TIA Flex vs. TIA Ext (p = 0.000), T1 Flex vs. T1 Ext (p = 0.000), Neck tilt Flex vs. Neck tilt Ext (p = 0.000), and COG-C7 Flex vs. COG-C7 Ext (p = 0.000). Conclusion: There was statistical significance in relation to the positioning of the upper limbs in the lateral radiographs, yielding higher values in the angulations with the limbs raised towards the front (extended elbows). Level of evidence II; Prospective Comparative Study.

Published
2021
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177. Die Krankheit des Ritters / der Ritter als Krankheit – Funktion(-alisierung-)en der Syphilis in Erasmus’ von Rotterdam Coniugum impar (1529)

Author

Lea Reiff

Subjects
Syphilis (lit. Motiv), Erasmus von Rotterdam, Ulrich von Hutten, Colloquia familiaria, Social sciences (General), H1-99
Abstract

Syphilis findet in Erasmus’ von Rotterdam Colloquia familiaria mehrfach Erwähnung. Insbesondere ein 1529 in die Sammlung aufgenommener Dialog mit dem Titel „Ἄγαμος γάμος sive Coniugum impar“ („Die ungleiche Ehe“) setzt sich mit dem Ende des 15. Jahrhunderts als neu wahrgenommenen Krankheit auseinander. In diesem Text werden Teile des semantischen Spektrums der Lepra durch Vergleich, Abgrenzung und Überbietung auf die Syphilis übertragen, was eine Lesbarkeit des kranken Körpers nicht nur als infektiös, sondern auch als sünden- und schuldbehaftet ermöglicht. In einer Lesart als Schlüsseltext wird der Dialog im Kontext einer schriftlich geführten Kontroverse zwischen Erasmus und Heinrich Eppendorf verortet, die auf ein früheres Zerwürfnis zwischen Erasmus und Ulrich von Hutten in den Jahren 1522/23 zurückgeht. Es wird herausgestellt, dass der syphilitische Bräutigam des „Coniugum impar“ auf Hutten verweist und mit ihm das Vorbild Eppendorfs diskreditiert. In allegorischer Lesart wird damit auch die Verdorbenheit des Standes der Reichsritter insgesamt herausgestellt.

Published
2021
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178. Targeted Ensemble Machine Classification Approach for Supporting IoT Enabled Skin Disease Detection

Author

Hong Qing Yu and Stephan Reiff-Marganiec

Subjects
Machine learning, artificial intelligent, healthcare, image classification, deep learning, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The fast development of the Internet of Things (IoT) changes our life in many areas, especially in the health domain. For example, remote disease diagnosis can be achieved more efficiently with advanced IoT-technologies which not only include hardware but also smart IoT data processing and learning algorithms, e.g. image-based disease classification. In this paper, we work in a specific area of skin condition classification. This research work aims to provide an implementable solution for IoT-led remote skin disease diagnosis applications. The research output can be concluded into three folders. The first folder is about dynamic AI model configuration supported IoT-Fog-Cloud remote diagnosis architecture with hardware examples. The second folder is the evaluation survey regarding the performances of machine learning models for skin disease detection. The evaluation contains a variety of data processing methods and their aggregations. The evaluation takes account of both training-testing and cross-testing validations on all seven conditions and individual condition. In addition, the HAM10000 dataset is picked for the evaluation process according to the suitability comparisons to other relevant datasets. In the evaluation, we discuss the earlier work of ANN, SVM and KNN models, but the evaluation process mainly focuses on six widely applied Deep Learning models of VGG16, Inception, Xception, MobileNet, ResNet50 and DenseNet161. The result shows that each of the top four models for the major seven skin conditions has better performance for the specific condition than others. Based on the evaluation discovery, the last folder proposes a novel classification approach of the Targeted Ensemble Machine Classify Model (TEMCM) to enable dynamically combining a suitable model in a two-phase detection process. The final evaluation result shows the proposed model can archive better performance.

Published
2021
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183. Direct-acting antiviral therapies for hepatitis C infection: global registration, reimbursement, and restrictions

Author

Marshall, Alison D, primary, Willing, Alex R, additional, Kairouz, Abe, additional, Cunningham, Evan B, additional, Wheeler, Alice, additional, O’Brien, Nicholas, additional, Perera, Vidura, additional, Ward, John W, additional, Hiebert, Lindsey, additional, Degenhardt, Louisa, additional, Hajarizadeh, Behzad, additional, Colledge, Samantha, additional, Hickman, Matthew, additional, Jawad, Danielle, additional, Lazarus, Jeffrey V, additional, Matthews, Gail V, additional, Scheibe, Andrew, additional, Vickerman, Peter, additional, Dore, Gregory J, additional, Grebely, Jason, additional, Sargsyants, N., additional, Suleymanova, L., additional, Salkic, N., additional, Simonova, M., additional, Nemeth-Blazic, T., additional, Mravcik, V., additional, Kivimets, K., additional, Salupere, R., additional, Butsashvili, M., additional, Soselia, G., additional, Makara, M., additional, Tolmane, I., additional, Jancorienė, L., additional, Stratulat, S., additional, Flisiak, R., additional, Gheorghe, L., additional, Cernat, R., additional, Lakhov, A., additional, Stanevich, O., additional, Jarcuska, P., additional, Peck-Radosavljevic, M., additional, Robaeys, G., additional, Øvrehus, A., additional, Foster, G., additional, Sutinen, J., additional, Farkkila, M., additional, Rautiainen, H., additional, Vuoti, S., additional, Nikolova, D., additional, Pawlotsky, J.M., additional, Rockstroh, J., additional, Sypsa, V., additional, Papatheodoridis, G., additional, Olafsson, S., additional, Feeney, E., additional, Teti, E., additional, Seguin-Devaux, C., additional, Pocock, J., additional, Reiff, S., additional, McDougall, N., additional, Van der Valk, M., additional, Dalgard, O., additional, Tato Marinho, R., additional, Dillon, J., additional, Peters, E., additional, Bojovic, K., additional, Matičič, M., additional, Kåberg, M., additional, Bruggmann, P., additional, Healy, B., additional, Chong, V.H., additional, Yi, S., additional, Tucker, J., additional, Pasaribu, L.R., additional, Tanaka, J., additional, Ashley, E.A., additional, Abu Hassan, M.R., additional, Mohammed, N.S., additional, Chan, H.K., additional, Gidaagaya, S., additional, Kyi, K.P., additional, Hyung Joon, K., additional, Chin, B., additional, Baladjay, P.C., additional, Kao, J.H., additional, Wansom, T., additional, da Cruz, B., additional, Flower, B., additional, Ehsan, E., additional, Al Mahtab, M., additional, Khandu, L., additional, Bhadoria, A.S., additional, Alavi, M., additional, KC, P., additional, Hamid, S., additional, Biryukov, S., additional, Alymbaeva, D., additional, Alaei, A., additional, Bakieva, S., additional, Flichman, D., additional, Carmo, R.F., additional, Valdez, E., additional, Cortes, C.P., additional, Contreras, F., additional, Teran, E., additional, Velez-Moller, P., additional, Jagnarine, T., additional, Mills, M., additional, Goodman-Meza, D., additional, Sánchez, J., additional, Montenegro-Idrogo, J.J., additional, Lugo Canales, A.M., additional, Davy, J., additional, Alexander, A., additional, Gerona, S., additional, Perazzo, R., additional, Balak, D., additional, Kelly-Hanku, A., additional, Fineanganofo, A., additional, Gane, E., additional, Raymond, N., additional, Debzi, N., additional, Sridharan, K., additional, Waked, I., additional, Turner, D., additional, Shibolet, O., additional, Al Muzaini, A., additional, El Nakib, M., additional, Sheriff, D.S., additional, Brahni, T., additional, Essayagh, T., additional, Essayagh, S., additional, Hjaija, D., additional, Al-Naamani, K., additional, Sanai, F.M., additional, Pasquale, H., additional, Bedri, S., additional, Chakroun, M., additional, Ghrabi, A., additional, Akarca, U.S., additional, Falcao, V., additional, Edmond Gbedo, S., additional, Ouoba, S., additional, Nyabenda, F., additional, Rocher Mbella, M., additional, Mahamat Moussa, A., additional, Youssouf, T., additional, Boniface, Y., additional, Akilimali Shindano, T., additional, Hamida, M.E., additional, Mongo, A., additional, Mapapa, C., additional, Desalegn, H., additional, Embinga, E.L.A., additional, Ndow, G., additional, Nartey, Y., additional, Cisse, M., additional, Djalo, M.A., additional, Mugambi, M., additional, Nyakowa, M., additional, Jeuronlon, M.K., additional, Ngoma, J., additional, Manitrala Ramanampamonjy, R., additional, Naik, K., additional, Soyjaudah, M.D., additional, Filipe, E., additional, Nnakelu, E., additional, Serumondo, J., additional, Mbodj, M., additional, Patino, M., additional, Aalto, M.K., additional, Waweru, P., additional, Dagnra, A., additional, Ocama, P., additional, Maghimbi, A., additional, Hamooya, B.M., additional, Katsidzira, L., additional, Rios, C., additional, Thormann, M., additional, Al Marzooqi, N., additional, Al Rand, H.M., additional, Francois, K., additional, Hamoudi, W., additional, Alkharty, M., additional, Skripo, O., additional, and Uka, T., additional

Published
2024
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186. Supplementary Figure S1 from First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma

Author

Woyach, Jennifer A., primary, Stephens, Deborah M., primary, Flinn, Ian W., primary, Bhat, Seema A., primary, Savage, Ronald E., primary, Chai, Feng, primary, Eathiraj, Sudharshan, primary, Reiff, Sean D., primary, Muhowski, Elizabeth M., primary, Granlund, Lindsey, primary, Szuszkiewicz, Lyndsey, primary, Wang, Wayne, primary, Schwartz, Brian, primary, Ghori, Razi, primary, Farooqui, Mohammed Z.H., primary, and Byrd, John C., primary

Published
2024
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189. Hyperdiploid acute lymphoblastic leukemia in children with LZTR1 germline variants

Author

Zipper, Lisa, primary, Wagener, Rabea, additional, Fischer, Ute, additional, Hoffmann, Anna, additional, Yasin, Layal, additional, Brandes, Danielle, additional, Soura, Stavrieta, additional, Anwar, Ammarah, additional, Walter, Carolin, additional, Varghese, Julian, additional, Hauer, Julia, additional, Auer, Franziska, additional, Bhatia, Sanil, additional, Dugas, Martin, additional, Junk, Stefanie V., additional, Stanulla, Martin, additional, Haas, Oskar A., additional, Borkhardt, Arndt, additional, Reiff, Tobias, additional, and Brozou, Triantafyllia, additional

Published
2024
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194. First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma

Author

Woyach, Jennifer A., primary, Stephens, Deborah M., additional, Flinn, Ian W., additional, Bhat, Seema A., additional, Savage, Ronald E., additional, Chai, Feng, additional, Eathiraj, Sudharshan, additional, Reiff, Sean D., additional, Muhowski, Elizabeth M., additional, Granlund, Lindsey, additional, Szuszkiewicz, Lyndsey, additional, Wang, Wayne, additional, Schwartz, Brian, additional, Ghori, Razi, additional, Farooqui, Mohammed Z.H., additional, and Byrd, John C., additional

Published
2023
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199. High-normal PaCO2 values might be associated with worse outcome in patients with subarachnoid hemorrhage – a retrospective cohort study

Author

Tilman Reiff, Oliver Barthel, Silvia Schönenberger, and Sibu Mundiyanapurath

Subjects
Subarachnoid hemorrhage, Hypercapnia, Carbon dioxide reactivity, Risk factors, Outcome, Partial pressure of carbon dioxide, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. Methods Consecutive patients with aneurysmal subarachnoid hemorrhage (aSAH) requiring mechanical ventilation treated in a tertiary care university hospital were retrospectively analyzed regarding the influence of PaCO2 on favorable outcome, defined as modified Rankin scale score

Published
2020
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200. A Multi-Objective Optimized Service Level Agreement Approach Applied on a Cloud Computing Ecosystem

Author

Leonildo Jose de Melo de Azevedo, Julio Cezar Estrella, Claudio Fabiano Motta Toledo, and Stephan Reiff-Marganiec

Subjects
Cloud computing ecosystem, metaheuristics, multi-objective optimized, SLA, QoS, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The cloud ecosystem provides transformative advantages that allow elastically offering on-demand services. However, it is not always possible to provide adequate services to all customers and thus to fulfill service level agreements (SLA). To enable compliance with these agreements, service providers leave the customer responsible for determining the service settings and expect that the client knows what to do. Some studies address SLA compliance, but the existing works do not adequately address the problem of resource allocation according to clients' needs since they consider a limited set of objectives to be analyzed and fulfilled. In previous work, we have already addressed the problem considering a single-objective approach. In that work, we identified that the problem has a multi-objective characteristic since several attributes simultaneously influence the SLA agreement, which can lead to conflicts. This paper proposes a multi-objective combinatorial optimization approach for computational resources provisioning, seeking to optimize the efficient use of the infrastructure and provide the client with greater flexibility in contract closure.

Published
2020
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