151. Impact of Previous Virological Treatment Failures and Adherence on the Outcome of Antiretroviral Therapy in 2007
- Author
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Marie Ballif, Bruno Ledergerber, Manuel Battegay, Matthias Cavassini, Enos Bernasconi, Patrick Schmid, Bernard Hirschel, Hansjakob Furrer, Martin Rickenbach, Milos Opravil, Rainer Weber, Swiss HIV Cohort Study, Swiss HIV Cohort Study, Battegay, M., Bernasconi, E., Böni, J., Bucher, HC., Bürgisser, P., Calmy, A., Cattacin, S., Cavassini, M., Dubs, R., Egger, M., Elzi, L., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Furrer, H., Fux, C., Gorgievski, M., Günthard, H., Hirsch, H., Hirschel, B., Hösli, I., Kahlert, Ch., Kaiser, L., Karrer, U., Kind, C., Klimkait, T., Ledergerber, B., Martinetti, G., Martinez, B., Müller, N., Nadal, D., Opravil, M., Paccaud, F., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schüpbach, J., Speck, R., Taffe, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., University of Zurich, and Ledergerber, B
- Subjects
Male ,HIV Infections/ drug therapy ,Public Health and Epidemiology/Infectious Diseases ,lcsh:Medicine ,HIV Infections ,10234 Clinic for Infectious Diseases ,Cohort Studies ,Epidemiology ,ddc:576.5 ,Treatment Failure ,lcsh:Science ,Multidisciplinary ,Anti-Retroviral Agents/pharmacology/ therapeutic use ,Infectious Diseases/HIV Infection and AIDS ,Viral Load ,Middle Aged ,RNA, Viral/genetics ,Adult ,Anti-Retroviral Agents/pharmacology ,Anti-Retroviral Agents/therapeutic use ,Drug Therapy, Combination ,Female ,Follow-Up Studies ,HIV Infections/drug therapy ,HIV-1/drug effects ,Humans ,Medication Adherence ,Patient Selection ,Switzerland ,Viral Load/drug effects ,Anti-Retroviral Agents ,Virology/Immunodeficiency Viruses ,RNA, Viral ,Viral load ,Research Article ,Cohort study ,Cart ,medicine.medical_specialty ,610 Medicine & health ,1100 General Agricultural and Biological Sciences ,Pharmacotherapy ,1300 General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,medicine ,1000 Multidisciplinary ,business.industry ,lcsh:R ,Odds ratio ,Surgery ,Clinical trial ,Regimen ,HIV-1 ,lcsh:Q ,business - Abstract
BACKGROUND: Combination antiretroviral treatment (cART) has been very successful, especially among selected patients in clinical trials. The aim of this study was to describe outcomes of cART on the population level in a large national cohort. METHODS: Characteristics of participants of the Swiss HIV Cohort Study on stable cART at two semiannual visits in 2007 were analyzed with respect to era of treatment initiation, number of previous virologically failed regimens and self reported adherence. Starting ART in the mono/dual era before HIV-1 RNA assays became available was counted as one failed regimen. Logistic regression was used to identify risk factors for virological failure between the two consecutive visits. RESULTS: Of 4541 patients 31.2% and 68.8% had initiated therapy in the mono/dual and cART era, respectively, and been on treatment for a median of 11.7 vs. 5.7 years. At visit 1 in 2007, the mean number of previous failed regimens was 3.2 vs. 0.5 and the viral load was undetectable (4 previous failures compared to 1 were 0.9 (95% CI 0.4-1.7), 0.8 (0.4-1.6), 1.6 (0.8-3.2), 3.3 (1.7-6.6) respectively, and 2.3 (1.1-4.8) for >2 missed cART doses during the last month, compared to perfect adherence. From the cART era, odds ratios with a history of 1, 2 and >2 previous failures compared to none were 1.8 (95% CI 1.3-2.5), 2.8 (1.7-4.5) and 7.8 (4.5-13.5), respectively, and 2.8 (1.6-4.8) for >2 missed cART doses during the last month, compared to perfect adherence. CONCLUSIONS: A higher number of previous virologically failed regimens, and imperfect adherence to therapy were independent predictors of imminent virological failure.
- Published
- 2009