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151. Faïences et majoliques, du xve au début du xviie siècle en France, à partir des découvertes archéologiques: pour un bilan des connaiss

Author

Alban Horry and Fabienne Ravoire

Subjects
General Medicine
Abstract

Problematique scientifique Lors du colloque consacre aux majoliques du xvie au debut du xviie siecle, qui s’etait tenu a Anvers en 1999, une premiere esquisse de la diffusion de ce type de production en France de ces periodes avait ete proposee par F. Ravoire . Celle-ci a permis de mettre en evidence une dynamique d’implantation des officines et de diffusion des productions favorisee par les reseaux politiques et economiques de la diaspora italienne installee en France. La question de l’origi...

Published
2010
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152. [The place of a new drug in the therapeutic strategy]

Author

A, Castaigne, J M, Goehrs, and S, Ravoire

Subjects
Drug Industry, Drug Therapy, Drug-Related Side Effects and Adverse Reactions, Pharmaceutical Preparations, Drug Evaluation, Humans, Practice Patterns, Physicians', Case Management
Abstract

A therapeutic strategy is a hierarchical set of appropriate measures to provide an answer to a pathological state. A drug is a part of this set (together with the diagnosis, the environment and the other medicinal interventions or not). A new drug's place in a therapeutic strategy can be evaluated according to one or several referential(s) when it (or they) exist, referentials which express the state of knowledge before launch of the new drug. The drug's profile (indication or contraindication, etc.), at the point when the marketing authorization is given, is purely theoretical. One must evaluate the real place of the drug under its real conditions of use (pragmatic trials, observable surveys). A new drugs' place in a therapeutic strategy can only be evaluated in the course of time unless a therapeutic revolution occurs.

Published
2000

153. Faïences et majoliques, du xve au début du xviie siècle en France, à partir des découvertes archéologiques: pour un bilan des connaissances

Author

Fabienne Ravoire and Alban Horry

Subjects
lcsh:D111-203, majolique, lcsh:Medieval history, faïence
Abstract

Problématique scientifiqueLors du colloque consacré aux majoliques du xvie au début du xviie siècle, qui s’était tenu à Anvers en 1999, une première esquisse de la diffusion de ce type de production en France de ces périodes avait été proposée par F. Ravoire . Celle-ci a permis de mettre en évidence une dynamique d’implantation des officines et de diffusion des productions favorisée par les réseaux politiques et économiques de la diaspora italienne installée en France. La question de l’origin...

Published
2006

156. Recherche précompétitive, une mise en synergie des ressources publiques et privées : pour quels objectifs, comment et dans quel cadre juridique ?

Author

Vassal, Gilles, primary, Neves, Carole, additional, Arnaud, Olivier, additional, Pletan, Yannick, additional, Amedee-Manesme, Olivier, additional, Antoun, Zeina, additional, Audry, Antoine, additional, Auffret, Alexandra, additional, Blin, Olivier, additional, Bril, Antoine, additional, Braquet, Pierre, additional, Courcier, Soizic, additional, Delval, Cécile, additional, Mainard, Jacques Demotes, additional, Diaz, Isabelle, additional, Lemonier, Elisabeth Fery, additional, Giri, Isabelle, additional, Izard, Valérie, additional, Labonne, Valéry, additional, Louvet, Olivier, additional, Bressac, Isabelle Pelletier, additional, Ravoire, Sophie, additional, Schiavi, Pierre, additional, Vasmant, Daniel, additional, and Vassal, Gilles, additional

Published
2011
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159. Comparators (Medicinal and non Medicinal) for Marketing Authorization, for Public Health, for Payers and at the European Level

Author

Berdaï, Driss, primary, Hotton, Jean-Michel, additional, Lechat, Philippe, additional, Barna, Alexandre, additional, Becquemont, Laurent, additional, Bergman, Jean-François, additional, Bernaud, Corine, additional, Boucot, Isabelle, additional, Cheiney, Isabelle, additional, Cucherat, Michel, additional, d’Andon, Anne, additional, d’Enfert, Jérôme, additional, Francillon, Alain, additional, Frauger, Elisabeth, additional, Girault, Danièle, additional, Harlin, Jean-Marc, additional, Joseph, Alain, additional, Lassale, Catherine, additional, Mahlberg-Gaudin, Florence, additional, Moreau-Defarges, Thierry, additional, Pavlovic, Mira, additional, Ravoire, Sophie, additional, Rochaix, Lise, additional, and Vicaut, Eric, additional

Published
2010
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160. Les comparateurs (médicamenteux et non médicamenteux) pour l’autorisation de mise sur le marché, pour la santé publique, pour les payeurs et au niveau européen

Author

Berdaï, Driss, primary, Hotton, Jean-Michel, additional, Lechat, Philippe, additional, Barna, Alexandre, additional, Becquemont, Laurent, additional, Bergman, Jean-François, additional, Bernaud, Corine, additional, Boucot, Isabelle, additional, Cheiney, Isabelle, additional, Cucherat, Michel, additional, d’Andon, Anne, additional, d’Enfert, Jérôme, additional, Francillon, Alain, additional, Frauger, Elisabeth, additional, Girault, Danièle, additional, Harlin, Jean-Marc, additional, Joseph, Alain, additional, Lassale, Catherine, additional, Mahlberg-Gaudin, Florence, additional, Moreau-Defarges, Thierry, additional, Pavlovic, Mira, additional, Ravoire, Sophie, additional, Rochaix, Lise, additional, and Vicaut, Eric, additional

Published
2010
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161. Value of Post-Registration Studies for Reimbursement Renewal

Author

Molimard, Mathieu, primary, Bamberger, Marion, additional, Vray, Muriel, additional, Allicar, Marie-Pierre, additional, Ameye, Véronique, additional, Avouac, Bernard, additional, Banzet, Marie-Noëlle, additional, Becquemont, Laurent, additional, Blin, Patrick, additional, Duguay, Corinne, additional, Fagnani, Francis, additional, Girault, Danièle, additional, Haim, Muriel, additional, Hamers, Françoise, additional, Lalaude, Olivier, additional, Lamarque, Véronique, additional, Maillere, Patricia, additional, Massol, Jacques, additional, Maugendre, Philippe, additional, Meyer, Arlette, additional, Moreau-Defarges, Thierry, additional, Pathak, Atul, additional, Perillat, Anne, additional, Ravoire, Sophie, additional, Spriet, Alain, additional, Tardieu, Sophie, additional, Teisseire, Bernard, additional, Weber, Monique, additional, and Zanetti, Laura, additional

Published
2009
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162. Recherche non interventionnelle et soins courants : définition, aspects réglementaires, difficultés et propositions

Author

Lemaire, François, primary, Ravoire, Sophie, additional, Golinelli, Danielle, additional, Barraud, Béatrice, additional, Becquemont, Laurent, additional, Billon, Nathalie, additional, Birraux, Guillaume, additional, Cellier, Dominic, additional, Childs, Mark, additional, Daurat, Véronique, additional, Deplanque, Dominique, additional, Depont-Hebert, Fanny, additional, Fourrier-Reglat, Annie, additional, Frija-Orvoen, Elisabeth, additional, Gaudin, Anne-Françoise, additional, Esteller, Sylvie Hansel, additional, Lalaude, Olivier, additional, Laurent-Vo, Jean-Marc, additional, Lebrun, Eléonore, additional, Lechat, Philippe, additional, Libersa, Christian, additional, Massol, Jacques, additional, Maugendre, Philippe, additional, Montestruc, François, additional, Rey-Quinio, Catherine, additional, Rusch, Philippe, additional, Sibenaler, Claire, additional, Simon, Tabassome, additional, Tardieu, Sophie, additional, Van Ganse, Eric, additional, Vial, Thierry, additional, and Zanetti, Laura, additional

Published
2008
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163. Non-interventional Research and Usual Care: Definition, Regulatory Aspects, Difficulties and Recommendations

Author

Lemaire, François, primary, Ravoire, Sophie, additional, Golinelli, Danielle, additional, Barraud, Béatrice, additional, Becquemont, Laurent, additional, Billon, Nathalie, additional, Birraux, Guillaume, additional, Cellier, Dominic, additional, Childs, Mark, additional, Daurat, Véronique, additional, Deplanque, Dominique, additional, Depont-Hebert, Fanny, additional, Fourrier-Reglat, Annie, additional, Frija-Orvoen, Elisabeth, additional, Gaudin, Anne-Françoise, additional, Esteller, Sylvie Hansel, additional, Lalaude, Olivier, additional, Laurent-Vo, Jean-Marc, additional, Lebrun, Eléonore, additional, Lechat, Philippe, additional, Libersa, Christian, additional, Massol, Jacques, additional, Maugendre, Philippe, additional, Montestruc, François, additional, Rey-Quinio, Catherine, additional, Rusch, Philippe, additional, Sibenaler, Claire, additional, Simon, Tabassome, additional, Tardieu, Sophie, additional, Van Ganse, Eric, additional, Vial, Thierry, additional, and Zanetti, Laura, additional

Published
2008
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165. In vitro and in vivo ciprofloxacin pharmacokinetics in human neutrophils

Author

Philippe Lapalus, D. Jambou, R. M. Chichmanian, Rodolphe Garraffo, and S. Ravoire

Subjects
Adult, Male, Neutrophils, Biology, Pharmacology, In Vitro Techniques, Pharmacokinetics, Body Water, In vivo, Ciprofloxacin, medicine, Extracellular, Humans, Pharmacology (medical), Chromatography, High Pressure Liquid, Intracellular parasite, Area under the curve, In vitro, Infectious Diseases, Female, Intracellular, medicine.drug, Half-Life, Research Article
Abstract

Early in vitro investigations have shown that ciprofloxacin is concentrated within human neutrophils (polymorphonuclear leukocytes [PMNs]) at between 3 and 11 times the extracellular concentration. The elution of ciprofloxacin from cells is relatively rapid when the extracellular concentration is reduced. In order to estimate the in vivo intracellular penetration of ciprofloxacin and to determine its intracellular pharmacokinetics, PMNs were recovered from blood samples drawn from healthy volunteers at different times during a 24-h period after they were given a 750-mg oral dose. High-performance liquid chromatographic determination of ciprofloxacin in serum and cells showed that the intracellular/serum ratio was 3.7 at 1.5 h (maximum concentration of drug in serum), 5.7 at 12 h, and 20 at 24 h. The area under the curve ratio was 3.73. The mean elimination half-lives of ciprofloxacin were 3.7 and 6.2 h in serum and PMNs, respectively. These data show that in vivo findings are in agreement with in vitro findings. The large uptake of ciprofloxacin by PMNs combined with a prolonged intracellular half-life described under the conditions of human therapy should provide the basis for the use of ciprofloxacin in infections caused by susceptible intracellular bacteria.

Published
1991

166. Un ensemble céramique du XIVe siècle : la fosse L1 des thermes de Cluny à Paris

Author

Fabienne Ravoire, Centre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales (CRAHAM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), and Institut national de recherches archéologiques préventives (Inrap)

Subjects
General Arts and Humanities, Techniques et savoirs pratiques, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract

Dieser Aufsatz bezweckt, unseren Kenntnisstand uber die Pariser Sachkultur des XVI. Jd. zu erweitern. Es wird Gebrauchsgeschirr — nahezu 200 GefâBe — untersucht. Die Gebrauchskeramik dieses Zeitabschnitts wurde bislang nur punktuell untersucht, und allein die Emailarbeiten der Kûnstler wie Bernard Palissy, Masséot Abasquesne oder der Kunstlerfamilie Delia Robbia haben bisher offenbar Beachtung gefunden. Es scheint als erwiesen, daB Welten den Kûnstler vom Handwerker trennen ; es trifft indes auch zu, daB Alltagsgeschirr ebenfalls Wandlungen unterworfen ist. Diversifikation und Erneuerung der Formen belegen eine Entwicklung von Geschmack, Sitte sowie Mentalitàt : Der Zeitgeist verschrieb sich der «Modernitàt ». Diese Keramiksamm-lung ist von groBem Interesse, sie unterrichtet uns nâmlich uber Gebrauchsgegenstânde aus dem Alltagsleben, jedoch auch iiber einige seltenere Stiicke, die wàhrend der Renaissance in Paris in Gebrauch waren., This article aims at furthering our knowledge of the Parisian material culture of the XVIth century through the study of an assemblage or ordinary table ware consisting of almost 200 recipients. The ordinary wares of this period have only formed the subject of a very few selective studies, and only the art of the artist enamellists such as Bernard Palissy, Massèot Abasquesne or the Delia Robbias seem to have held our attention. If it seems true that a world of difference separated the artist from the artisan, it is no less true that changes are also noticeable in ordinary table ware. Diversification and renewal of the forms bear witness to an evolution in tastes, way of life and attitudes : «modernism » is in the air. This group of pottery is of great interest because it gives us information about objects used from day to day, and also on a few rare items used in Paris during the Renaissance., Cet article a pour but d'enrichir la connaissance de la culture matérielle parisienne du XVIe siècle à travers un ensemble de vaisselles usuelles de près de 200 vases. La céramique commune de cette période n'a encore fait l'objet que de très rares études ponctuelles, et seul l'art des artistes émailleurs tels les Bernard Palissy, Masséot Abasquesne ou les Delia Robbia semble avoir retenu l'attention. S'il semble certain qu'un monde sépare l'artiste de l'artisan, il n'en est pas moins vrai que des changements sont aussi perceptibles dans la vaisselle courante. Diversification et renouvellement des formes témoignent d'une évolution du goût, des mœurs et des mentalités : l'air du temps est à la «modernité ». Cet ensemble de céramiques est d'un grand intérêt car il nous renseigne sur les objets de la vie quotidienne mais aussi sur quelques pièces plus rares, en usage à Paris durant la Renaissance., Ravoire Fabienne. Un ensemble céramique du XVIe siècle : la fosse L1 des thermes de Cluny à Paris. In: Archéologie médiévale, tome 21, 1991. pp. 209-270.

Published
1991
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169. Faecal excretion of ciprofloxacin after a single oral dose and its effect on faecal bacteria in healthy volunteers

Author

Sophie Pecquet, Antoine Andremont, and Sophie Ravoire

Subjects
Pharmacology, Microbiology (medical), Adult, Streptococcus, Biology, medicine.disease_cause, biology.organism_classification, Enterobacteriaceae, Microbiology, Excretion, Ciprofloxacin, Bacteria, Anaerobic, Feces, Infectious Diseases, Oral administration, medicine, Humans, Pharmacology (medical), Staphylococcus, Antibacterial agent, medicine.drug
Abstract

High concentrations of ciprofloxacin have been shown to persist in the faeces of volunteers for several days after a week of oral treatment with this drug, which was also found to have a prolonged effect on aerobic Gram-negative intestinal bacteria. To determine whether a shorter course of ciprofloxacin would have the same prolonged effect, we treated ten healthy adult volunteers with a single oral dose of 750 mg ciprofloxacin and found that this was not followed by any significant changes in the counts of anaerobes or streptococci, but that there was a mean decrease of 2.5 log10 cfu/ml in the counts of faecal Enterobacteriaceae, which lasted for a full week. We attributed this to the persistence of high faecal ciprofloxacin concentrations for several days in all the volunteers. We did not observe any significant increase in the MICs of ciprofloxacin for faecal Enterobacteriaceae, or any faecal overgrowth of staphylococci, fungi, Pseudomonas aeruginosa or Clostridium difficile.

Published
1990

170. Effect of a magnetic field on the resonant multistep selective photoionization of gadolinium isotopes

Author

R. Botter, A. Petit, J. Ravoire, E. Le Guyadec, F. Lambert, C.E. Valrho (DCC/DTE/SLC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
010302 applied physics, Physics, Photon, [PHYS.PHYS.PHYS-ATOM-PH]Physics [physics]/Physics [physics]/Atomic Physics [physics.atom-ph], Gadolinium, Photoionization mode, chemistry.chemical_element, Isotopes of gadolinium, Photoionization, 7. Clean energy, 01 natural sciences, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Magnetic field, Optical pumping, chemistry, 0103 physical sciences, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Physics::Atomic Physics, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, Atomic physics, 010306 general physics, Hyperfine structure, ComputingMilieux_MISCELLANEOUS
Abstract

A multistep photoionization with three resonant polarized photons has been used to separate the odd and even isotopes of gadolinium. Due to their hyperfine structure (I= 3 2 ), the 155,157Gd isotopes can be photoionized via a J=2→2→1→0 scheme with three п photons whereas the even isotopes cannot. If a time delay is introduced between the three laser pulses we show that the presence of a low intensity dc magnetic field affects the selectivity. The effect of this weak field on the 156Gd photoionization rate has been calculated independently of the optical pumping and the result is in good agreement with the experiment.

Published
1990
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173. Le réseau des Centres de Ressources Biologiques Humains

Author

Clément, Bruno, primary, Grimaud, Jean-Alexis, additional, Deleuze, Jean-François, additional, Postaire, Eric, additional, Barilero, I., additional, Becquemont, L., additional, Bertoye, P.-H., additional, Bonnavita, M.-J., additional, Bricca, G., additional, Clément, B., additional, Deleuze, J.-F., additional, Deplanque, D., additional, Desbois, I., additional, Deugnier, Y., additional, Di Donato, J.-H., additional, Grimaud, J.-A., additional, Haiech, J., additional, Lassale, C., additional, Laurent-Vo, J.-M., additional, Libersa, C., additional, Paintaud, G., additional, Pinard-Duchamp, D., additional, Plouin, P.-F., additional, Postaire, E., additional, Ravoire, S., additional, Réchaussat, L., additional, Reynier, J.-C., additional, and Vella, P., additional

Published
2005
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174. The Human Biological Resource Centres Network

Author

Clément, Bruno, primary, Grimaud, Jean-Alexis, additional, Deleuze, Jean-François, additional, Postaire, Eric, additional, Barilero, I., additional, Becquemont, L., additional, Bertoye, P.-H., additional, Bonnavita, M.-J., additional, Bricca, G., additional, Clément, B., additional, Deleuze, J.-F., additional, Deplanque, D., additional, Desbois, I., additional, Deugnier, Y., additional, Di Donato, J.-H., additional, Grimaud, J.-A., additional, Haiech, J., additional, Lassale, C., additional, Laurent-Vo, J.-M., additional, Libersa, C., additional, Paintaud, G., additional, Pinard-Duchamp, D., additional, Plouin, P.-F., additional, Postaire, E., additional, Ravoire, S., additional, Réchaussat, L., additional, Reynier, J.-C., additional, and Vella, P., additional

Published
2005
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176. Lecture critique, évaluation, valorisation, information sur les résultats des grands essais cliniques

Author

Fouchard, Marie, primary, Zannad, Faiez, additional, Autret-Leca, E., additional, Bader, J.-P., additional, Bellet, M., additional, Bergmann, J.-F., additional, Bernard-Harlaud, M., additional, Bernaud, C., additional, Bordet, R., additional, Bouvenot, G., additional, Brun-Strang, C., additional, Castaigne, A., additional, Dumarcet, N., additional, Eschwège, E., additional, Gallard, M., additional, Giri, I., additional, Hamelin, B., additional, Jeanblanc, A., additional, Jolliet, P., additional, Kolsky, H., additional, Lagarde, D., additional, Lapeyre, G., additional, Lassale, C., additional, Lehner, J.-P., additional, Lelouët, H., additional, Malbezin, M., additional, Paulmier-Bigot, S., additional, Pigeon, M., additional, Ravoire, S., additional, Ricordeau, P., additional, Rouveix, B., additional, Soletti, J., additional, Tardieu, S., additional, Thomas, J.-L., additional, and Thuillez, C., additional

Published
2004
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177. The Results of Major Clinical Trials

Author

Fouchard, Marie, primary, Zannad, Faiez, additional, Autret-Leca, E., additional, Bader, J.-P., additional, Bellet, M., additional, Bergmann, J.-F., additional, Bernard-Harlaud, M., additional, Bernaud, C., additional, Bordet, R., additional, Bouvenot, G., additional, Brun-Strang, C., additional, Castaigne, A., additional, Dumarcet, N., additional, Eschwège, E., additional, Gallard, M., additional, Giri, I., additional, Hamelin, B., additional, Jeanblanc, A., additional, Jolliet, P., additional, Kolsky, H., additional, Lagarde, D., additional, Lapeyre, G., additional, Lassale, C., additional, Lehner, J.-P., additional, Lelouët, H., additional, Malbezin, M., additional, Paulmier-Bigot, S., additional, Pigeon, M., additional, Ravoire, S., additional, Ricordeau, P., additional, Rouveix, B., additional, Soletti, J., additional, Tardieu, S., additional, Thomas, J.-L., additional, and Thuillez, C., additional

Published
2004
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179. Public Information about Clinical Trials and Research

Author

Plétan, Yannick, primary, Zannad, Faïez, additional, Jaillon, Patrice, additional, Autret-Leca, E., additional, Belorgey, Ch., additional, Bernard-Harlaut, M., additional, Cellier, D., additional, Chazelle, F., additional, Chevallier-Le Guyader, M.F., additional, Couderc, M., additional, Debiais, D., additional, D’Enfert, J., additional, Duguet, A.M., additional, Fleury, L., additional, Gallard, M., additional, Giacomino, A., additional, Juillet, Y., additional, Kolsky, H., additional, Lehner, J.P., additional, Lemaire, F., additional, Padioleau, M.F., additional, Peschanski, M., additional, Ravoire, S., additional, Reynier, J.P., additional, Ricordeau, Ph., additional, Sassano, P., additional, Sibenaler, C., additional, Simon, M.C., additional, and Soletti, J., additional

Published
2003
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180. Information du public sur les essais cliniques et la recherche

Author

Plétan, Yannick, primary, Zannad, Faïez, additional, Jaillon, Patrice, additional, Autret-Leca, E., additional, Belorgey, Ch., additional, Bernard-Harlaut, M., additional, Cellier, D., additional, Chazelle, F., additional, Chevallier-Le Guyader, M.F., additional, Couderc, M., additional, Debiais, D., additional, D’Enfert, J., additional, Duguet, A.M., additional, Fleury, L., additional, Gallard, M., additional, Giacomino, A., additional, Juillet, Y., additional, Kolsky, H., additional, Lehner, J.P., additional, Lemaire, F., additional, Padioleau, M.F., additional, Peschanski, M., additional, Ravoire, S., additional, Reynier, J.P., additional, Ricordeau, Ph., additional, Sassano, P., additional, Sibenaler, C., additional, Simon, M.C., additional, and Soletti, J., additional

Published
2003
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181. Faecal excretion of ciprofloxacin after a single oral dose and its effect on faecal bacteria in healthy volunteers.

Author

Pecquet, Sophie, Ravoire, Sophie, Andremont, Antoine, Pecquet, S, Ravoire, S, and Andremont, A

Abstract

High concentrations of ciprofloxacin have been shown to persist in the faeces of volunteers for several days after a week of oral treatment with this drug, which was also found to have a prolonged effect on aerobic Gram-negative intestinal bacteria. To determine whether a shorter course of ciprofloxacin would have the same prolonged effect, we treated ten healthy adult volunteers with a single oral dose of 750 mg ciprofloxacin and found that this was not followed by any significant changes in the counts of anaerobes or streptococci, but that there was a mean decrease of 2.5 log10 cfu/ml in the counts of faecal Enterobacteriaceae, which lasted for a full week. We attributed this to the persistence of high faecal ciprofloxacin concentrations for several days in all the volunteers. We did not observe any significant increase in the MICs of ciprofloxacin for faecal Enterobacteriaceae, or any faecal overgrowth of staphylococci, fungi, Pseudomonas aeruginosa or Clostridium difficile. [ABSTRACT FROM AUTHOR]

Published
1990

186. Études post-AMM : apport dans la réinscription des produits

Author

Molimard, Mathieu, Bamberger, Marion, Vray, Muriel, Allicar, Marie-Pierre, Ameye, Véronique, Avouac, Bernard, Banzet, Marie-Noëlle, Becquemont, Laurent, Blin, Patrick, Duguay, Corinne, Fagnani, Francis, Girault, Danièle, Haim, Muriel, Hamers, Françoise, Lalaude, Olivier, Lamarque, Véronique, Maillere, Patricia, Massol, Jacques, Maugendre, Philippe, Meyer, Arlette, Moreau-Defarges, Thierry, Pathak, Atul, Perillat, Anne, Ravoire, Sophie, Spriet, Alain, Tardieu, Sophie, Teisseire, Bernard, MoniqueWeber, and Zanetti, Laura

Abstract

Les études post-inscription documentent, en situation réelle, les conditions de mise sous traitement, les populations réellement traitées, les durées de traitement, l’observance, les bénéfices des traitements, l’impact du traitement sur les stratégies thérapeutiques, l’organisation des soins et l’impact de santé publique, . . . Leurs données sont utilisées notamment lors d’une réévaluation anticipée ou lors du renouvellement d’inscription au remboursement. Cent trente quatre demandes de la Commission de la Transparence (CT) et/ou du Comité Économique des Produits de Santé (CEPS) ont été faites depuis 1997 et leurs résultats sont pris en compte et participent à la réévaluation du Service Médical Rendu (SMR) et de l’Amélioration du Service Médical Rendu (ASMR) anticipés. Au cours de cette table ronde des Rencontres Nationales de Pharmacologie Clinique de Giens, les difficultés de réalisation des études post-inscription médicaments ont été identifiées et des propositions ont été formulées dans les domaines du dialogue autour de la demande, de la prévisibilité et de l’anticipation des demandes et de la formation des médecins.

Published
2009
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188. Tritium content in a firn core from Antarctica

Author

J. Ravoire, J. Robert, C. Lorius, and E. Roth

Subjects
Hydrology, Atmospheric Science, Ecology, Firn, Paleontology, Soil Science, Forestry, Aquatic Science, Oceanography, Atmospheric sciences, Snow, Core (optical fiber), Atmosphere, Geophysics, Hydrology (agriculture), Space and Planetary Science, Geochemistry and Petrology, Earth and Planetary Sciences (miscellaneous), Tritium, Precipitation, Radioactive decay, Geology, Earth-Surface Processes, Water Science and Technology
Abstract

Tritium in a firn core from the coastal zone of Adelie Coast, Antarctica, has been determined by gas-counting after samples were enriched by thermal diffusion. Measurements have been made down to a depth of 10 meters, which corresponds to a water equivalent of 5.35 meters. Each sample represents about 15 cm of water equivalent. Mean annual snow accumlation has been determined by tritium fallout from nuclear tests of 1954 and by radioactive decay of natural tritium. The values found by fallout and by radioactive decay are, respectively, 21 and 20 g cm−2 yr−1. The agreement with data obtained by other methods is very good. Mean natural tritium content at the time of precipitation is 11.3 tritium units (TU), which corresponds to a rate of precipitation of natural tritium of 0.5 tritium atom cm−2 sec−1. Important fluctuations arise in the natural tritium content of precipitation. An attempt to correlate tritium precipitation and solar activity is made difficult by the irregularity of snow accumulation at the site of the core.

Published
1970
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189. Tritium and deuterium content of the snow in Groenland

Author

C. Lorius, J. Ravoire, L. Merlivat, and J.P. Vergnaud

Subjects
Hydrology, East coast, Firn, Snow, Geophysics, Altitude, Deuterium, Space and Planetary Science, Geochemistry and Petrology, Earth and Planetary Sciences (miscellaneous), Tritium, West coast, Precipitation, Geology
Abstract

Deuterium and tritium measurements were made on firn samples taken along a central axis across Greenland. Accumulation values determined from tritium profiles decrease regularly from 54.7 cm of water per year on the west coast to 18.1 cm of water per year on the east coast. A correlation is demonstrated between the tritium deposition rate and the altitude of the precipitation collection site.

Published
1973
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195. ALUMINA: CATALYST AND SUPPORT. XII.1 THE EFFECT OF INTRINSIC ACIDITY OF ALUMINAS UPON HYDROGEN—DEUTERIUM EXCHANGE

Author

Herman Pines and Jean Ravoire

Subjects
inorganic chemicals, Sodium aluminate, Hydrogen, Sodium, Inorganic chemistry, technology, industry, and agriculture, General Engineering, chemistry.chemical_element, equipment and supplies, Isotope separation, law.invention, Catalysis, chemistry.chemical_compound, chemistry, Deuterium, Aluminium, law, Hydrogen–deuterium exchange, Physical and Theoretical Chemistry, Nuclear chemistry
Abstract

The hydrogen--deuterium exchange on gamma -alumina was studied. The catalytic effect of the aluminas was correlated with the intrinsic acidity of the aluminas. Alumina prepared from aluminum isopropoxide and having relatively strong acid sites was about 60 times as active for the exchange reaction as an alumina catalyst prepared from sodium aluminate and containing less than 0.1% by weight of sodium. A mechanism for hydrogen-deuterium exchange is proposed. (auth)

Published
1961
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197. Etude des transferts gazeux par diffusion dans des conduites à symétrie axiale

Author

Ravoire, J.P., Unité de Science du Sol, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], METHODE NUMERIQUE
Abstract

* INRA, URD, Domaine St Paul, Site Agroparc, 84914 Avignon cedex 9 Diffusion du document : INRA, URD, Domaine St Paul, Site Agroparc, 84914 Avignon cedex 9

Published
1987

200. COURRIER.

Author

GAMORY, DOMINIQUE, REY, JÉRÔME, SALVADOR, PIERRE, RAVOIRE, ANDY, COLOMBEAU, HUBERT, RONDEPIERRE, CHRISTOPHE, FOUCHER, JOHANN, FOURNOL, MME, COUSSEAU, SOPHIE, and PEIGNE, BENOÎT

Published
2009

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