151. Growth hormone releasing peptides: a comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells
- Author
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Kang Cheng, Bridget Butler, Jeffrey Cheng, and Tsuei-Ju Wu
- Subjects
Male ,medicine.medical_specialty ,Peptide ,Structural difference ,Growth hormone ,Growth Hormone-Releasing Hormone ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Internal medicine ,medicine ,Gh release ,Animals ,GHRP-6 ,General Pharmacology, Toxicology and Pharmaceutics ,Rats, Wistar ,Receptor ,Cells, Cultured ,chemistry.chemical_classification ,Chemistry ,Antagonist ,Drug Synergism ,General Medicine ,Hormones ,Rats ,Rat Pituitary ,Endocrinology ,Growth Hormone ,Pituitary Gland ,Oligopeptides - Abstract
In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6. In the rat system, GHRP-2, like GHRP-6, acts synergistically with GRF to release GH. Co-administration of GHRP-2 and GHRP-6 at maximal concentrations had no further effect on GH release than either one alone. The GHRP's were able to desensitize cells to each other, but not to GRF. The effect of GHRP-2 was inhibited by Peptide Antagonist, but was not affected by a GRF antagonist. In conclusion, GHRP-2 was found to stimulate GH release from rat pituitary cells via the same receptor and mechanism as GHRP-6, despite the structural difference between the peptides.
- Published
- 1997