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Background: Laryngoscopy and endotracheal intubation are usually associated with tachycardia and hypertension. Pre-administration of melatonin has anxiolytic and sedative property which can reduce the tachycardia and hypertension during the surgical procedures. Aims and Objectives: The present study aimed to evaluate the melatonin effect on hemodynamic changes during laryngoscopy and intubation. Materials and Methods: This prospective study was done in the department of anesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka. Total 80 patients were included in the study based on the inclusion and exclusion criteria. Patients were divided into two groups. Group-A treated with placebo and Group-B treated with melatonin (6 mg) and demographic, clinical, and hemodynamic parameters were recorded. The data were analyzed with unpaired t-test with the use SPSS (20.0) version software. Results: Comparison of number and percentage of age, gender, and blood groups between the Group-I and Group-II not showed any significant difference. Group-I and Group-II mean age, height, and weight not showed any significant difference. Mean heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were compared between the Group-I and Group-II at basal, during, after 1, 3, 5, and 10 min showed significant difference. Conclusion: Pre-administration melatonin showed significant reduction of hemodynamic changes compared to placebo group.

The aim of the current research is to assess the anticancer activity of the proteins identified from the crude protein extract derived from Hermetiaillucens larvae by computational methods. Bioinformatics methods were used to identify the protein sequence and virtual screening for the prediction of protein structure, their physico-chemical characteristics and functional aspects, that aid in exploring the anti-cancer interaction that is inclined to inhibit the oncoprotein activity. Due to the pathological process transpired by HPV, an array of genetic alterations, including the overexpression of oncoproteins or the inactivation of tumor suppressor proteins like TP53, BCL2, MDM2, ARF and BAX occur. The altered protein signaling pathways convulse to cervical cancer. In this research, we identified proteins, from the crude extract derived from Hermetiaillucens by LC-MS method. Further Computational screening of the selected proteins were employed to assess the functional units which has anticancer activity. We predicted four proteins Metallothionine, Defensin like precursor 1 protein, Heat shock protein 90 and NADH dehydrogenase and eluted the protein sequence from NCBI GenBank database. These sequences were used to predict physicochemical properties and protein structure prediction. Pharmacophore analysis of the peptide sequences as potential targets for cancer treatment was evaluated. Molecular docking of peptide sequences with target protein structure was carried out. To screen the best active potential molecule for cancer treatment the Molecular dynamics of docked protein-peptide structures were administered. The molecular docking of the peptides with onco-proteins has been predicted and virtually screened based on RMSD values. The resultant protein sequence was evaluated further by amino acid sequencing, extensive scrutiny of the proteins, advanced computational imaging, molecular docking examination and assessed the results for clinical interpretation. To summate, bioinformatics assessment enabled us to identify four key proteins derived from Hermetiaillucens larvae that have strong inhibitory function against proteins that cause cervical cancer.

Background: Sleep-disordered breathing (SDB), predominantly obstructive sleep apnea (OSA), is a frequent phenomenon in interstitial lung disease (ILD) and may be associated with significant morbidity and mortality. Methodology: A prospective, observational, hospital-based study was conducted in a tertiary care hospital after ethics committee permission. The study group consisted of 100 consecutive ILD patients diagnosed by a multidisciplinary diagnosis. They were evaluated for the prevalence of SDB with a polysomnography after a comprehensive history, detailed clinical examination, calculation of various pretest probability scores, and relevant prerequisite workup. Results: Out of the total 100 ILD patients, 44 were male (44%) and 56 were female (56%). SDB was present in 57 (57%) patients. Of these, 29 (29%) were found to have only nocturnal oxygen desaturation (NOD), while 28 (28%) had OSA. The 28 cases of OSA were distributed as 15 mild OSA (53.57%), 10 moderate OSA (35.71%), and 3 severe OSA (10.71%). The patients were divided into the following four groups: total study Group (A), patients with OSA (Group B), patients with NOD without OSA (Group C), and no SDB (Group D). The mean forced vital capacity values predicted in the four groups were 53.67%, 50%, 45.56%, and 57.87%, respectively. The mean body mass index in the four groups was 24.56, 27, 26.98, and 24.89 kg/m2, respectively. The mean 6-min walk distance in the four groups was 280.7, 250, 256.65, and 311.4 m, respectively. The mean partial pressure of oxygen in the four groups was 65.65, 60, 62.10, and 75.66 mmHg, respectively. The mean apnea–hypopnea index in the study group was 2.98/h, 8.6/h with mild OSA, 21.69/h with moderate OSA, 48.78/h with severe OSA, 3.89/h in patients having NOD without OSA, and 2.54/h in patients with no SDB. Conclusion: SDB in ILD is associated with a significant impact on the cardinal determinants of functional capacity, lung function, and quality of life.

Plastic is a material that is used to a great extent. Nowadays Petroleum based plastics are widely used for the commercial purpose. This kind of plastics can take more than a century to degrade. Man made plastics have Polyurethane and Polyethylene polymers. It cannot be easily degraded by micro organisms as it don’t recognize as food. When burned plastics release cancer causing carcinogenic chemicals that are harmful to people and the environment. One eco friendly alternative the current commercial plastic is “Bio plastics”. Bio plastics are biodegradable plastics that have components derived directly from renewable raw plant materials. Seven type of bioplastics were made using various combinations of renewable raw materials and plasticizers. In this project, Cassava starch is used as a main biopolymer for the production of bio degradable bags.

Water is indispensable for all the life forms on earth. But the comprehensive quality of water such as free from chemical pollutants and microbial contaminants is vital. The present circumstance of industrialization and urbanization has taken a toll on environment, polluting the soil, air, and water. Pollution as well as global warming has exhibited detrimental effects on our natural resources of which water becomes the inexplicable. Failing monsoon rains due to climatic changes, population explosion, and depletion of natural water resources such as groundwater, ponds, and lakes as well as intentional man-made pollution of rivers has lead to water scarcity. Even the scarcely available water is loaded by contaminants and pollutants which include mutagens, carcinogens, and pathogenic microbes affecting all the life forms affecting the ecological balance. Considering the above mentioned problem criteria, a part of the present work has been designed to analyze the quality of ground water around the industrial premises. For this objective, we have collected ground water samples from various locations in and around Perundurai area in Erode District focusing on quite far away from Industrial premises considering the concepts of leaching. Basic physio-chemical properties of the collected ground water samples have been analyzed by APHA standards. Comparative data analysis for the samples based on the analyzed parameters has been made. Highest possibility of water quality issues which affects the day to day consumption of ground water for the domestic needs of the people has been emphasized.

Solid wastes are the inevitable production of the operations of various industries like construction Industry, Machines Manufacturing Units, Textile industry etc. In India the construction industry generates large amounts of waste, which can be composed of different origin materials, most of them classified as non-hazardous. Construction and Demolition waste (CDW) constitutes a major portion of total solid waste production in the world and most of it is used in landfills. Dumping of these construction and demolition waste in landfill causes contamination of soil, water and air from toxic substances. Research by structural concrete engineers has clearly suggested the possibility of appropriately treating and reusing such waste as aggregates in new concrete. The aim of this paper is to explore the separation process of CDW and further use of recycled aggregates from construction and demolition waste (CDW) in concrete mixes. A review of most recent research and legislation applied in India is developed regarding the production of concrete by using these recycled aggregates.

Septic system plays a major role in sanitary disposal activities. In developing country it is very essential for proper disposal of wastes for providing clean environment. In our country the government has adopted scheme, “CLEAN INDIA”,. For achieving this aim, the septic system is necessary to construct in each and every residential, commercial buildings and public areas. Septic tank systems are a type of simple onsite sewage facility.But groundwater pollution may occur and can create a problem. Usage of mobile septic tank can be helpful to avoid such problem. In this present investigation an idea has been arrived and the septic tank constructed by the way which have been tested for 10 days for decomposition using microbes. The term ‘septic’ refer to the anaerobic bacteria environment that develops in the tanks which decomposes or mineralizes the water discharged into the tank. The rate of accumulation of sludge is faster than rate of decomposition. So in our project we have used microbes for decomposition.In urban areas, construction of septic tanks are easier. But in rock exposures, the septic tanks cannot be constructed easily. In this paper, the problem is solved by giving an idea as solution by providing a “MOBILE SEPTIC TANK”. This will be helpful and eliminate such problems.