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786 results on '"Rama, B."'

156. Design optimization and experimental characterization of a rotary magneto-rheological fluid damper to control torsional vibration

Author

Ramin Sedaghati, Ehab Abouobaia, and Rama B. Bhat

Subjects
010302 applied physics, Physics, Torsional vibration, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, Damper, Magnetic circuit, Mechanics of Materials, Control theory, 0103 physical sciences, Signal Processing, Magnetorheological fluid, Torque, General Materials Science, Electrical and Electronic Engineering, 0210 nano-technology, Damping torque, Bingham plastic, Civil and Structural Engineering, Sequential quadratic programming
Abstract

This paper aims at optimum design formulation of a rotary disk-type magneto-rheological (MR) fluid damper to increase its torsional vibration control performance. The objective is to maximize the torsional damping torque for a given volume, geometric and inertia constraints. The damping torque has been derived based on Bingham plastic model for a commercial MR fluid provided by Lord corporation. As MR fluid's yield strength directly depends on the applied magnetic field intensity, an analytical magnetic circuit analysis has been conducted to approximately evaluate the magnetic field intensity in the MR fluid gap. A finite element model of the rotary MR damper has also been developed to evaluate the magnetic field distribution. A formal design optimization problem has then been formulated to maximize the dynamic range for a given volume under geometric, inertia and torque ratio constraints. Genetic Algorithm (GA) combined with Sequential Quadratic Programming (SQP) method has been utilized to accurately capture the global optimum solution. Finally, a proof-of-concept of the optimal design has been manufactured and then tested experimentally to investigate the generated damping torque under different current excitation and also to validate the model and optimization strategy.

Published
2020
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162. Principles of Aeroelasticity

Author

Rama B. Bhat

Subjects
Airfoil, business.industry, Mathematical analysis, Equations of motion, Aerodynamics, Structural engineering, Aeroelasticity, Finite element method, Physics::Fluid Dynamics, Nonlinear system, Flutter, business, Galerkin method, Mathematics
Abstract

Introduction Elementary Aerodynamics General Concepts The Joukowski Transformation for Airfoils Dimensional Analysis of Force Experienced by a Solid Body in a Flow Static Aeroelasticity Introduction Determination of Shear Center in a Thin-Walled Section Divergence of a Lifting Surface Introduction Divergence of a Typical Section with a Control Surface Introduction Control Surface Reversal Dynamic Aeroelasticity Introduction Vibration Theory Damped Single DOF System Energy Method Sinusoidal Excitation Periodic Force Arbitrary Force Two DOF System Equations of Motion of a Two DOF Model of an Aircraft Wing Quasi-Steady Aerodynamic Theory Can Flutter Be Seen If Only Torsional Motion Is Considered? Dynamics of Airfoil Random Motion One-Dimensional Aeroelastic Model of Airfoils Introduction Simple Torsion of a Bar General Approximations for Aerodynamic Theory Eigenvalue and Eigenfunction Approaches Rolling of a Straight Wing Introduction Determination of Aerodynamic Influence Functions Flutter of a Cantilever Wing Introduction Simple Bending of Beams Stability of the Motion Approximate Techniques of Modeling Continuous Systems Influence Coefficient Method Galerkin's Method Rayleigh-Ritz Method Finite Element Method Assembly of Finite Elements Finite Element Representation of the Response and Flutter Problems Elastic Foundation Eigenfunctions and Eigenvalues Nonairfoil Physical Problems Divergence Stall Flutter Flutter and Buffeting of Bridges Aeroelasticity of Turbomachinery Blades Nonlinear Aeroelasticity Generic Nonlinear Aeroelastic Behavior One Degree of Freedom Nonlinear System: Divergence One Degree of Freedom System: Dynamic Effects Two Degrees of Freedom System: Dynamic Effects Unsteady Aerodynamics Introduction Theodorsen's Unsteady Thin-Airfoil Theory Flutter Prediction via Assumed Modes References

Published
2018
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180. Intergenerational Programming in Extension: Needs Assessment as Planning Tool.

Author

Kaplan, Matthew, Liu, Shih-Tsen, and Radhakrishna, Rama B.

Abstract

A needs assessment of 161 Extension educators in family and consumer science and 4-H/youth development received 28 responses indicating preferences regarding intergenerational program content and delivery format. Results were used to develop curriculum and program delivery strategies and begin planning for a statewide intergenerational program. (SK)

Published
2003

182. Development of a new torsional vibration damper incorporating conventional centrifugal pendulum absorber and magnetorheological damper

Author

Rama B. Bhat, Ramin Sedaghati, and Ehab Abouobaia

Subjects
Engineering, Torsional vibration, business.industry, Mechanical Engineering, 02 engineering and technology, Structural engineering, 021001 nanoscience & nanotechnology, 01 natural sciences, Damper, Dynamic Vibration Absorber, Active vibration control, Tuned mass damper, 0103 physical sciences, Magnetorheological fluid, General Materials Science, Magnetorheological damper, Centrifugal pendulum absorber, Physics::Chemical Physics, 0210 nano-technology, business, 010301 acoustics
Abstract

Excessive torsional vibrations in mechanical systems with rotating mechanical components result in noise, excessive stresses, or even fatigue failure if not suppressed or controlled properly. Accordingly, they should be suppressed or controlled immediately to ensure system’s reliability. In this study, a hybrid torsional vibration damper is proposed incorporating a conventional centrifugal pendulum vibration absorber and a magnetorheological damper. While centrifugal pendulum vibration absorbers are simple and reliable than passive torsional vibration absorbers, their performance is limited to the designed tuning conditions. Magnetorheological dampers have recently received considerable attention due to their inherent fail-safe feature, low power requirement, and capability to attenuate vibration under unpredictable environmental conditions. This research aims at developing a novel hybrid torsional vibration damper combining conventional centrifugal pendulum vibration absorber with the magnetorheological rotary damper in which the centrifugal pendulum vibration absorber has been connected to the cylindrical housing of the magnetorheological damper. The analytical model of the rotor system integrated with proposed hybrid torsional damper has been developed. The superior performance of the proposed torsional damper has been then demonstrated by comparing the results with those of rotor system without any damper, rotor system with only centrifugal pendulum vibration absorber, and finally rotor system with only magnetorheological rotary damper.

Published
2015
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183. Integrated ride and handling vehicle model using Lagrangian quasi-coordinates

Author

Rama B. Bhat, Wen-Fang Xie, and Ali Fellah Jahromi

Subjects
Coupling, Engineering, Current (mathematics), business.industry, Motion (geometry), Control engineering, Degrees of freedom (mechanics), Longitudinal direction, symbols.namesake, Dynamic models, Control theory, Automotive Engineering, Euler's formula, symbols, business, Lagrangian
Abstract

In this study, a methodology to build a new integrated ride and handling model is presented based on the Lagrangian method in terms of quasi-coordinates. The governing equations are derived considering the interaction between the ride and handling systems, Euler motion of the frames attached to the wheels and body, the load transfer among the wheels, and the variation of speed in longitudinal direction. The developed model is validated using ADAMS/Car for different maneuvers. In addition, a non-dimensional factor called coupling factor is introduced to study the coupling among different DOFs of the dynamic system. The results of the current study confirm the accuracy of the developed dynamic model for the simulation of the vehicle motion in comparison with the ADAMS/Car simulations and the models available in literature. The coupling factor is confirmed as an indicator parameter to demonstrate the advantages of the developed model over the existing dynamic models.

Published
2015
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184. The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author

Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H. -C., Dubner, S. J., Halperin, J. L., C. S., Ma, Zint, K., Elsaesser, A., Bartels, D. B., Lip, G. Y. H., Abban, D., Abdul, N., Abelson, M., Ackermann, A., Adams, F., Adams, L., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Marin, J. A., Aguilar, F., Aguilar Linares, J. A., Aguinaga, L., Ahmad, Z., Ainsworth, P., Al Ghalayini, K., Al Ismail, S., Alasfar, A., Alawwa, A., Al-Dallow, R., Alderson, L., Alexopoulos, D., Ali, A., Ali, M., Aliyar, P., Al-Joundi, T., Al Mahameed, S., Almassi, H., Almuti, K., Al-Obaidi, M., Alshehri, M., Altmann, U., Alves, A. R., Al-Zoebi, A., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrawis, N., Angoulvant, D., Annoni, G., Ansalone, G., Antonescu, S. A., Ariani, M., Arias, J. C., Armero, S., Arora, R., Arora, C., Ashcraft, W., Aslam, M. S., Astesiano, A., Audouin, P., Augenbraun, C., Aydin, S., Azar, R., Azim, A., Aziz, S., Backes, L. M., Baig, M., Bains, S., Bakbak, A., Baker, S., Bakhtiar, K., Bala, R., Banayan, J., Bandh, S., Bando, S., Banerjee, S., Bank, A., Barbarash, O., Baron, G., Barr, C., Barrera, C., Barton, J., Kes, V. B., Baula, G., Bayeh, H., Bazargani, N., Behrens, S., Bell, A., Benezet-Mazuecos, J., Benhalima, B., Berdague, P., Berg van den, B. J., Bergen van, P. F. M. M., Berngard, E., Bernstein, R., Berrospi, P., Berti, S., Bertomeu, V., Berz, A., Bettencourt, P., Betzu, R., Beyer-Westendorf, J., Bhagwat, R., Black, T., Blanco Ibaceta, J. H., Bloom, S., Blumberg, E., Bo, M., Bockisch, V., Bohmer, E., Bongiorni, M. G., Boriani, G., Bosch, R., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Brandes, A., Bratland, B., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Bruguera, J., Brunehaut, M., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Butcher, K., Cabrera Honorio, J. W., Caccavo, A., Cadinot, D., Cai, S., Calvi, V., Camm, J., Candeias, R., Capo, J., Capucci, A., Cardoso, J. N., Duarte Vera, Y. C., Carlson, B., Carvalho, P., Cary, S., Casanova, R., Casu, G., Cattan, S., Cavallini, C., Cayla, G., Cha, T. J., Cha, K. S., Chaaban, S., Chae, J. K., Challappa, K., Chand, S., Chandrashekar, H., Chang, M., Charbel, P., Chartier, L., Chatterjee, K., Cheema, A., Chen, S. -A., Chevallereau, P., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, D. J., Chouinard, G., Danny, Chow, H. F., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Cieza-Lara, T., Nica, V. C., Ciobotaru, V., Cislowski, D., Citerne, O., Claus, M., Clay, A., Clifford, P., Cohen, S., Cohen, A., Colivicchi, F., Collins, R., Compton, S., Connors, S., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Corbett, L., Corey, O., Coronel, J., Corrigan, J., Cotrina Pereyra, R. Y., Cottin, Y., Coutu, B., Cracan, A., Crean, P., Crenshaw, J., Crijns, H. J. G. M., Crump, C., Cucher, F., Cudmore, D., Cui, L., Culp, J., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davee, T., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De La Briolle, A., de Mora, M., De Teresa, E., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deluche, L., Destrac, S., Deumite, N. J., Di Legge, S., Dibon, O., Diemberger, I., Dillinger, J., Dionisio, P., Naydenov, S., Dotani, I., Dotcheva, E., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duthinh, V., Dutra, O. P., Dutta, D., Duvilla, N., Dy, J., Dziewas, R., Eaton, C., Eaves, W., Ebinger, M., Eck van, J. W. M., Edwards, T., Egocheaga, I., Ehrlich, C., Eisenberg, S., El Hallak, A., El Jabali, A., El Mahmoud, R., El Shahawy, M., Eldadah, Z., Elghelbazouri, F., Elhag, O., El-Hamdani, M., Elias, D., Ellery, A., El-Sayed, H., Elvan, A., Erickson, B., Espaliat, E., Essandoh, L., Everington, T., Evonich, R., Ezhov, A., Facila, L., Farsad, R., Fayard, M., Fedele, F., Gomes Ferreira, L. G., Ferreira, D., Santos, J. F., Ferrier, A., Finsen, A., First, B., Fisher, R., Floyd, J., Folk, T., Fonseca, C., Fonseca, L., Forman, S., Forsgren, M., Foster, M., Foster, N., Frais, M., Frandsen, B., Frappe, T., Freixa, R., French, W., Freydlin, M., Frickel, S., Fruntelata, A. G., Fujii, S., Fujino, Y., Fukunaga, H., Furukawa, Y., Gabelmann, M., Gabris, M., Gadsboll, N., Galin, P., Galinier, M., Ganim, R., Garcia, R., Quintana, A. G., Gartenlaub, O., Genz, C., Georger, F., Georges, J. -L., Georgeson, S., Ghanbasha, A., Giedrimas, E., Gierba, M., Gillespie, E., Giniger, A., Gkotsis, A., Gmehling, J., Gniot, J., Goethals, P., Goldberg, R., Goldmann, B., Goldscher, D., Golitsyn, S., Gomez Lopez, E. A., Gomez Mesa, J. E., Gonzalez, E., Cocina, E. G., Juanatey, C. G., Gorbunov, V., Gordon, B., Gorka, H., Gornick, C., Gorog, D., Goss, F., Gotte, A., Goube, P., Goudevenos, I., Goulden, D., Graham, B., Grande, A., Greco, C., Green, M., Greer, G., Gremmler, U., Grena, P., Grinshstein, Y., Grond, M., Gronda, E., Grondin, F., Gronefeld, G., Groot de, J. R., Guardigli, G., Guarnieri, T., Caiedo, C. G., Guignier, A., Gulizia, M., Gumbley, M., Gupta, D., Hack, T., Haerer, W., Hakas, J., Hall, C., Hampsey, J., Hananis, G., Hanbali, B., Handel, F., Hargrove, J., Hargroves, D., Harris, K., Hartley, D., Haruna, T., Hata, Y., Hayek, E., Healey, J., Hearne, S., Heggelund, G., Hemels, M. E. W., Hemery, Y., Henein, S., Henz, B., Her, S. -H., Hermany, P., Hernandes, M. E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hitchcock, J., Hoffer, E., Hoghton, M., Holmes, C., Hong, S. K., Houppe Nousse, M. -P., Howard, V., Hsu, L. F., Huang, C. -H., Huckins, D., Huehnergarth, K., Huizenga, A., Huntley, R., Hussein, G., Hwang, G. -S., Igbokidi, O., Iglesias, I., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Ionova, T., Ip, J., Irles, D., Iseki, H., Ismail, Y., Israel, N., Isserman, S., Iteld, B., Ivanchura, G., Iyer, R., Iyer, V., Iza Villanueva, R. O., Jackson-Voyzey, E., Jaffrani, N., Jager, F., Jain, M., James, M., Jamon, Y., Jang, S. W., Pereira Jardim, C. A., Jarmukli, N., Jeanfreau, R., Jenkins, R., Jiang, X., Jiang, H., Jiang, T., Jiang, N., Jimenez, J., Jobe, R., Joffe, I., Johansson, B., Jones, N., Moura Jorge, J. C., Jouve, B., Jundi, M., Jung, W., Jung, B. C., Jung, K. T., Kabbani, S., Kabour, A., Kafkala, C., Kajiwara, K., Kalinina, L., Kampus, P., Kanda, J., Kapadia, S., Karim, A., Karolyi, L., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J., Keeling, P., Kerfes, G. A., Kerr Saraiva, J. F., Ketova, G., Khaira, A., Khalid, M., Khludeeva, E., Khripun, A., Kim, D. I., Kim, D. K., Kim, N. H., Kim, K. S., Kim, Y. -H., Kim, J. B., Kim, J. S., Kinova, E., Klein, A., Kleinschnitz, C., Kmetzo, J., Kneller, G. L., Knezevic, A., Koch, S., Koenig, K., Angela Koh, S. M., Kohrmann, M., Koons, J., Korabathina, R., Korennova, O., Koschutnik, M., Kosinski, E., Kovacic, D., Kowalczyk, J., Koziolova, N., Kragten, J. A., Krause, L. U., Kreidieh, I., Krenning, B. J., Krishnaswamy, K., Krysiak, W., Kuck, K. -H., Kumar, S., Kumler, T., Kuniss, M., Kuo, J. -Y., Kuppers, A., Kurrelmeyer, K., Kwan, T., Kyo, E., Labovitz, A., Lacroix, A., Lam, A., Lanas Zanetti, F. T., Landau, C., Landini, G., Lang, W., Larsen, T. B., Laske, V., Lavandier, K., Law, N., Lee, M. H., Lee, D., Leitao, A., Lejay, D., Lelonek, M., Lenarczyk, R., Leprince, P., Lequeux, B., Leschke, M., Ley, N., Li, Z., Li, Y., Li, X., Li, W., Liang, J., Lieber, I., Lillestol, M., Limon Rodriguez, R. H., Lin, H., Lip, G., Litchfield, J., Liu, Z., Liu, X., Liu, Y., Liu, F., Liu, W., Llamas Esperon, G. A., Llisterri, J. L., Lo, T., Lo, E., Lobos, J. M., Lodde, B. -P., Loiselet, P., Lopez-Sendon, J., Lorga Filho, A. M., Lori, I., Luo, M., Lupovitch, S., Lyrer, P., Zuhairy, H. M., Ma, C., Ma, G., Ma, H., Madariaga, I., Maeno, K., Magnin, D., Mahmood, S., Mahood, K., Maid, G., Mainigi, S., Makaritsis, K., Maldonado Villalon, J. A., Malhotra, R., Malik, A., Mallecourt, C., Mallik, R., Manning, R., Manolis, A., Mantas, I., Manzur Jattin, F. G., Marcionni, N., Marin, F., Santana, A. M., Martinez, J., Martinez, L., Maskova, P., Hernandez, N. M., Matskeplishvili, S., Matsuda, K., Mavri, A., May, E., Mayer, N., Mazon, P., Mcclure, J., Mccormack, T., Mcgarity, W., Mcguire, M., Mcintyre, H., Mclaughlin, P., Mclaurin, B., Medina Palomino, F. A., Mehta, P., Mehzad, R., Meinel, A., Melandri, F., Mena, A., Meno, H., Menzies, D., Metcalf, K., Meyer, B., Miarka, J., Mibach, F., Michalski, D., Michel, P., Chreih, R. M., Mikdadi, G., Mikhail, M., Mikus, M., Milicic, D., Militaru, C., Miller, G., Milonas, C., Minescu, B., Mintale, I., Miralles, A., Mirault, T., Mistry, D., Mitchell, G., Miu, N. V., Miyamoto, N., Moccetti, T., Mohammed, A., Nor, A. M., Molina de Salazar, D. I., Molon, G., Molony, D., Mondillo, S., Mont, L., Moodley, R., Moore, R., Ribeiro Moreira, D. A., Mori, K., Moriarty, A., Morka, J., Moschos, N., Mota Gomes, M. A., Mousallem, N., Moya, A., Mugge, A., Mulhearn, T., Muller, J. -J., Muresan, C. M., Muse, D., Musial, W., Musumeci, F., Nadar, V., Nageh, T., Nair, P., Nakagawa, H., Nakamura, Y., Nakayama, T., Nam, K. -B., Napalkov, D., Natarajan, I., Nayak, H., Nechvatal, L., Neiman, J., Nerheim, P., Neuenschwander, F. C., Nishida, K., Nizov, A., Novikova, T., Novo, S., Nowalany-Kozielska, E., Nsah, E., Nunez Fragoso, J. C., Nyvad, O., de Los Rios Ibarra, M. O., O'Donnell, M., O'Donnell, P., D. J., Oh, Y. S., Oh, Daniel Oh, C. T., O'Hara, G., Oikonomou, K., Olalla, J. J., Olivari, Z., Oliver, R., Olympios, C., Osborne, J., Osca, J., Osman, R., Osunkoya, A., Padanilam, B., Panchenko, E., Pandey, A. S., Vicenzo de Paola, A. A., Paraschos, A., Pardell, H., Park, H. W., Park, J. S., Parkash, R., Parker, I., Parrens, E., Parris, R., Passamonti, E., Patel, J., Patel, R., Pentz, W. H., Persic, V., Perticone, F., Peters, P., Petkar, S., Pezo, L. F., Pham, D., Cao Phai, G. P., Phlaum, S., Pineau, J., Pineda-Velez, A., Pini, R., Pinter, A., Pinto, F., Pirelli, S., Pivac, N., Pizzini, A. M., Pocanic, D., Calin Podoleanu, C. G., Polanczyk, C. A., Polasek, P., Poljakovic, Z., Pollock, S., Polo, J., Poock, J., Poppert, H., Porro, Y., Pose, A., Poulain, F., Poulard, J. -E., Pouzar, J., Povolny, P., Pozzer, D., Pras, A., Prasad, N., Prevot, S., Protasov, K., Prunier, L., Puleo, J., Pye, M., Qaddoura, F., Quedillac, J. -M., Raev, D., Rahimi, S., Raisaro, A., Rama, B., Ranadive, N., Randall, K., Ranjith, N., Raposo, N., Rashid, H., Raters, C., Rauch-Kroehnert, U., Rebane, T., Regner, S., Renzi, M., Reyes Rocha, M. A., Reza, S., Ria, L., Richter, D., Rickli, H., Rickner, K., Rieker, W., Rigo, F., Ripoll, T., Fonteles Ritt, L. E., Roberts, D., Pascual, C. R., Briones, I. R., Reyes, H. R., Roelke, M., Roman, M., Romeo, F., Ronner, E., Ronziere, T., Rooyer, F. A., Rosenbaum, D., Roth, S., Rozkova, N., Rubacek, M., Rubalcava, F., Rubanenko, O., Rubin, A., Borret, M. R., Rybak, K., Sabbour, H., Morales, O. S., Sakai, T., Salacata, A., Salecker, I., Salem, A., Salfity, M., Salguero, R., Salvioni, A., Samson, M., Sanchez, G., Sandesara, C., Saporito, W. F., Sasaoka, T., Sattar, P., Savard, D., Scala, P. -J., Scemama, J., Schaupp, T., Schellinger, P., Scherr, C., Schmitz, K. -H., Schmitz, B., Schmitz, L., Schnitzler, R., Schnupp, S., Schoeniger, P., Schon, N., Schuster, S., Schwimmbeck, P., Seamark, C., Seebass, R., Seidl, K. -H., Seidman, B., Sek, J., Sekaran, L., Seko, Y., Sepulveda Varela, P. A., Sevilla, B., Shah, V., Shah, A., Shah, N., Shanes, J., Sharareh, A., Sharma, V. K., Shaw, L., Shimizu, Y., Shimomura, H., Shin, D. G., Shin, E. -S., Shite, J., Shoukfeh, M., Shoultz, C., Silver, F., Sime, I., Simmers, T. A., Singal, D., Singh, N., Siostrzonek, P., Sirajuddin, M., Skeppholm, M., Smadja, D., Smith, R., Smith, D., Soda, H., Sofley, C. W., Sokal, A., Sotolongo, R., de Souza, O. F., Sparby, J. A., Spinar, J., Sprigings, D., Spyropoulos, A., Stakos, D., Steinberg, A., Steinwender, C., Stergiou, G., Stites, H. W., Stoikov, A., Strasser, R., Streb, W., Styliadis, I., Su, G., Su, X., Suarez, R. M., Sudnik, W., Sueyoshi, A., Sukles, K., Sun, L., Suneja, R., Svensson, P., Ziekenhuis, A., Szavits-Nossan, J., Taggeselle, J., Takagi, Y., Takhar, A., Tallet, J., Tamm, A., Tanaka, S., Tanaka, K., Tang, A., Tang, S., Tassinari, T., Tayama, S., Tayebjee, M., Tebbe, U., Teixeira, J., Tesloianu, D. N., Tessier, P., The, S. H. K., Thevenin, J., Thomas, H., Timsit, S., Topkis, R., Torosoff, M., Touze, E., Traissac, T., Trendafilova, E., Troyan, B., Tsai, W. K., Tse, H. F., Tsutsui, H., Tsutsui, T., Tuininga, Y. S., Turakhia, M., Turk, S., Turner, W., Tveit, A., Twiddy, S., Tytus, R., Ukrainski, G., Valdovinos Chavez, S. B., Van De Graaff, E., Vanacker, P., Vardas, P., Vargas, M., Vassilikos, V., Vazquez, J., Venkataraman, A., Verdecchia, P., Vester, E. G., Vial, H., Vinereanu, D., Vlastaris, A., Vogel, C., vom Dahl, J., von Mering, M., Vora, K., Wakefield, P., Walia, J., Walter, T., Wang, M., Wang, N., Wang, F., Wang, X., Wang, Z., Wang, K. -Y., Watanabe, K., Wei, J., Weimar, C., Weinrich, R., Wen, M. -S., Wheelan, K., Wicke, J., Wiemer, M., Wild, B., Wilke, A., Willems, S., Williams, M., Williams, D., Winkler, A., Wirtz, J. H., Witzenbichler, B., Wong, D. H. K., Lawrence Wong, K. S., Wong, B., Wozakowska-Kaplon, B., Wu, Z., Wu, S., Wyatt, N., Xu, Y., Xu, X., Yamada, A., Yamamoto, K., Yamanoue, H., Yamashita, T., Bryan Yan, P. Y., Yang, Y., Yang, T., Yao, J., Yarlagadda, C., Yeh, K. -H., Yotov, Y., Yvorra, S., Zahn, R., Zamorano, J., Zanini, R., Zarich, S., Zebrack, J., Zenin, S., Zeuthen, E. L., Zhang, X., Zhang, Q., Zhang, D., Zhang, H., Zhao, S., Zhao, X., Zheng, Y., Zheng, Q., Zhou, J., Zimmermann, S. L., Zimmermann, R., Zukerman, L. S., Zwaan van der, C., Huisman, M, Rothman, K, Paquette, M, Teutsch, C, Diener, H, Dubner, S, Halperin, J, Ma, C, Zint, K, Elsaesser, A, Bartels, D, Lip, G, Abban, D, Abdul, N, Abelson, M, Ackermann, A, Adams, F, Adams, L, Adragão, P, Ageno, W, Aggarwal, R, Agosti, S, Marin, J, Aguilar, F, Aguilar Linares, J, Aguinaga, L, Ahmad, Z, Ainsworth, P, Al Ghalayini, K, Al Ismail, S, Alasfar, A, Alawwa, A, Al Dallow, R, Alderson, L, Alexopoulos, D, Ali, A, Ali, M, Aliyar, P, Al Joundi, T, Al Mahameed, S, Almassi, H, Almuti, K, Al Obaidi, M, Alshehri, M, Altmann, U, Alves, A, Al Zoebi, A, Amara, W, Amelot, M, Amjadi, N, Ammirati, F, Andrawis, N, Angoulvant, D, Annoni, G, Ansalone, G, Antonescu, S, Ariani, M, Arias, J, Armero, S, Arora, R, Arora, C, Ashcraft, W, Aslam, M, Astesiano, A, Audouin, P, Augenbraun, C, Aydin, S, Azar, R, Azim, A, Aziz, S, Backes, L, Baig, M, Bains, S, Bakbak, A, Baker, S, Bakhtiar, K, Bala, R, Banayan, J, Bandh, S, Bando, S, Banerjee, S, Bank, A, Barbarash, O, Barón, 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O, Iglesias, I, Ikpoh, M, Imberti, D, Ince, H, Indolfi, C, Ionova, T, Ip, J, Irles, D, Iseki, H, Ismail, Y, Israel, N, Isserman, S, Iteld, B, Ivanchura, G, Iyer, R, Iyer, V, Iza Villanueva, R, Jackson Voyzey, E, Jaffrani, N, Jäger, F, Jain, M, James, M, Jamon, Y, Jang, S, Pereira Jardim, C, Jarmukli, N, Jeanfreau, R, Jenkins, R, Jiang, X, Jiang, H, Jiang, T, Jiang, N, Jimenez, J, Jobe, R, Joffe, I, Johansson, B, Jones, N, Moura Jorge, J, Jouve, B, Jundi, M, Jung, W, Jung, B, Jung, K, Kabbani, S, Kabour, A, Kafkala, C, Kajiwara, K, Kalinina, L, Kampus, P, Kanda, J, Kapadia, S, Karim, A, Karolyi, L, Kashou, H, Kastrup, A, Katsivas, A, Kaufman, E, Kawai, K, Kawajiri, K, Kazmierski, J, Keeling, P, Kerfes, G, Kerr Saraiva, J, Ketova, G, Khaira, A, Khalid, M, Khludeeva, E, Khripun, A, Kim, D, Kim, N, Kim, K, Kim, Y, Kim, J, Kinova, E, Klein, A, Kleinschnitz, C, Kmetzo, J, Kneller, G, Knezevic, A, Koch, S, Koenig, K, Angela Koh, S, Köhrmann, M, Koons, J, Korabathina, R, Korennova, O, 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Manzur Jattin, F, Marcionni, N, Marín, F, Santana, A, Martinez, J, Martinez, L, Maskova, P, Hernández, N, Matskeplishvili, S, Matsuda, K, Mavri, A, May, E, Mayer, N, Mazon, P, Mcclure, J, Mccormack, T, Mcgarity, W, Mcguire, M, Mcintyre, H, Mclaughlin, P, Mclaurin, B, Medina Palomino, F, Mehta, P, Mehzad, R, Meinel, A, Melandri, F, Mena, A, Meno, H, Menzies, D, Metcalf, K, Meyer, B, Miarka, J, Mibach, F, Michalski, D, Michel, P, Chreih, R, Mikdadi, G, Mikhail, M, Mikus, M, Milicic, D, Militaru, C, Miller, G, Milonas, C, Minescu, B, Mintale, I, Miralles, A, Mirault, T, Mistry, D, Mitchell, G, Miu, N, Miyamoto, N, Moccetti, T, Mohammed, A, Nor, A, Molina de Salazar, D, Molon, G, Molony, D, Mondillo, S, Mont, L, Moodley, R, Moore, R, Ribeiro Moreira, D, Mori, K, Moriarty, A, Morka, J, Moschos, N, Mota Gomes, M, Mousallem, N, Moya, A, Mügge, A, Mulhearn, T, Muller, J, Muresan, C, Muse, D, Musial, W, Musumeci, F, Nadar, V, Nageh, T, Nair, P, Nakagawa, H, Nakamura, Y, Nakayama, T, Nam, K, Napalkov, D, Natarajan, I, Nayak, H, Nechvatal, L, Neiman, J, Nerheim, P, Neuenschwander, F, Nishida, K, Nizov, A, Novikova, T, Novo, S, Nowalany Kozielska, E, Nsah, E, Nunez Fragoso, J, Nyvad, O, de Los Rios Ibarra, M, O'Donnell, M, O'Donnell, P, Oh, D, Oh, Y, Daniel Oh, C, O'Hara, G, Oikonomou, K, Olalla, J, Olivari, Z, Oliver, R, Olympios, C, Osborne, J, Osca, J, Osman, R, Osunkoya, A, Padanilam, B, Panchenko, E, Pandey, A, Vicenzo de Paola, A, Paraschos, A, Pardell, H, Park, H, Park, J, Parkash, R, Parker, I, Parrens, E, Parris, R, Passamonti, E, Patel, J, Patel, R, Pentz, W, Persic, V, Perticone, F, Peters, P, Petkar, S, Pezo, L, Pham, D, Cao Phai, G, Phlaum, S, Pineau, J, Pineda Velez, A, Pini, R, Pinter, A, Pinto, F, Pirelli, S, Pivac, N, Pizzini, A, Pocanic, D, Calin Podoleanu, C, Polanczyk, C, Polasek, P, Poljakovic, Z, Pollock, S, Polo, J, Poock, J, Poppert, H, Porro, Y, Pose, A, Poulain, F, Poulard, J, Pouzar, J, Povolny, P, Pozzer, D, Pras, A, Prasad, N, Prevot, S, 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J, Zimmermann, S, Zimmermann, R, Zukerman, L, and Zwaan van der, C

Subjects
Male, oral anticoagulation, Internationality, Middle Aged, registry, Antithrombins, Dabigatran, Stroke, Cross-Sectional Studies, Fibrinolytic Agents, Humans, Female, atrial fibrillation, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine, Aged, Atrial Fibrillation
Abstract

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)

Published
2017

185. Professional Development Needs of State Extension Specialists.

Author

Radhakrishna, Rama B.

Abstract

Responses from 47 of 78 Clemson University extension specialists identified three critical professional development needs: communicating program impact to key decision makers, communicating client problems to researchers, and viewing problems from different perspectives. They felt that their expertise in other areas was high. (Contains 16 references.) (SK)

Published
2001

186. Governance of the Ocean, Coasts and the Cryosphere under Climate Change

Author

Pörtner, H.-O., Roberts, D C, Masson-Delmotte, V, Zhai, P, Tignor, M, Poloczanska, E, Mintenbeck, K, Alegría, A, Nicola, M, Okem, A, Petzold, J, Rama, B, Weyer, N M, Prakash, Anjal, Cassotta, Sandra, Glavovic, Bruce, Hinkel, Jochen, Holland, Elisabeth, Karim, Md Saiful, Orlove, Ben, Ratter, Beate, Rice, Jake, Rivera-Arriaga, Evelia, Sutherland, Catherine, Pörtner, H.-O., Roberts, D C, Masson-Delmotte, V, Zhai, P, Tignor, M, Poloczanska, E, Mintenbeck, K, Alegría, A, Nicola, M, Okem, A, Petzold, J, Rama, B, Weyer, N M, Prakash, Anjal, Cassotta, Sandra, Glavovic, Bruce, Hinkel, Jochen, Holland, Elisabeth, Karim, Md Saiful, Orlove, Ben, Ratter, Beate, Rice, Jake, Rivera-Arriaga, Evelia, and Sutherland, Catherine

Abstract

This Cross-Chapter Box outlines governance and associated institutional challenges and emerging solutions relevant to the ocean, coasts and cryosphere in a changing climate. It illustrates these through three cases: (Case 1) multi-level interactions in Ocean and Arctic governance; (Case 2) mountain governance; and (Case 3) coastal risk governance.

Published
2019

187. Changing Ocean, Marine Ecosystems, and Dependent Communities

Author

Pörtner, H.-O., Roberts, D.C., Masson-Delmotte, V., Zhai, P., Tignor, M., Poloczanska, E., Mintenbeck, K., Alegría, A., Nicolai, M., Okem, A., Petzold, J., Rama, B., Weyer, N.M., Bindoff, Nathaniel L., Cheung, William W.L, Kairo, James Gitundu, Arístegui, Javier, Guinder, Valeria Ana, Hallberg, Robert, Hilmi, Nathalie Jeanne Marie, Jiao, Nianzhi, Karim, Md Saiful, Levin, Lisa, O’Donoghue, Sean, Purca Cuicapusa, Sara Regina, Rinkevich, Baruch, Suga, Toshio, Tagliabue, Alessandro, Williamson, Phillip, Pörtner, H.-O., Roberts, D.C., Masson-Delmotte, V., Zhai, P., Tignor, M., Poloczanska, E., Mintenbeck, K., Alegría, A., Nicolai, M., Okem, A., Petzold, J., Rama, B., Weyer, N.M., Bindoff, Nathaniel L., Cheung, William W.L, Kairo, James Gitundu, Arístegui, Javier, Guinder, Valeria Ana, Hallberg, Robert, Hilmi, Nathalie Jeanne Marie, Jiao, Nianzhi, Karim, Md Saiful, Levin, Lisa, O’Donoghue, Sean, Purca Cuicapusa, Sara Regina, Rinkevich, Baruch, Suga, Toshio, Tagliabue, Alessandro, and Williamson, Phillip

Published
2019

188. Chapter 3: Polar Regions

Author

Pörtner, H.-O., Roberts, D.C., Masson-Delmotte, V., Zhai, P., Tignor, M., Poloczanska, E., Mintenbeck, K., Alegría, A., Nicolai, M., Okem, A., Petzold, J., Rama, B., Weyer, N.M., Meredith, Michael, Sommerkorn, M., Cassotta, S., Derksen, C., Ekaykin, A., Hollowed, A., Kofinas, G., Mackintosh, A., Melbourn-Thomas, J., Muelbert, M.M.C., Ottersen, G., Pritchard, Hamish, Schuur, E.A.G., Pörtner, H.-O., Roberts, D.C., Masson-Delmotte, V., Zhai, P., Tignor, M., Poloczanska, E., Mintenbeck, K., Alegría, A., Nicolai, M., Okem, A., Petzold, J., Rama, B., Weyer, N.M., Meredith, Michael, Sommerkorn, M., Cassotta, S., Derksen, C., Ekaykin, A., Hollowed, A., Kofinas, G., Mackintosh, A., Melbourn-Thomas, J., Muelbert, M.M.C., Ottersen, G., Pritchard, Hamish, and Schuur, E.A.G.

Published
2019

189. Chapter 1: Framing and Context of the Report

Author

Pörtner, H.-O., Roberts, D.C., Masson-Delmotte, V., Zhai, P., Tignor, M., Poloczanska, E., Mintenbeck, K., Alegría, A., Nicolai, M., Okem, A., Petzold, J., Rama, B., Weyer, N.M., Abram, N., Gattuso, J.-P., Prakash, A., Cheng, L., Chidichimo, M.P., Crate, S., Enomoto, H., Gaschagen, M., Gruber, N., Harper, S., Holland, E., Kudela, R.M., Rice, J., Steffen, K., von Schuckmann, K., Bindoff, N., Collins, S., Colvin, R., Farinotti, D., Hilmi, N., Hinkel, J., Hock, R., Magnan, A., Meredith, Michael P., Pandey, A., Shrestha, M.S., Sinisalo, A., Sutherland, C., Williamson, P., Pörtner, H.-O., Roberts, D.C., Masson-Delmotte, V., Zhai, P., Tignor, M., Poloczanska, E., Mintenbeck, K., Alegría, A., Nicolai, M., Okem, A., Petzold, J., Rama, B., Weyer, N.M., Abram, N., Gattuso, J.-P., Prakash, A., Cheng, L., Chidichimo, M.P., Crate, S., Enomoto, H., Gaschagen, M., Gruber, N., Harper, S., Holland, E., Kudela, R.M., Rice, J., Steffen, K., von Schuckmann, K., Bindoff, N., Collins, S., Colvin, R., Farinotti, D., Hilmi, N., Hinkel, J., Hock, R., Magnan, A., Meredith, Michael P., Pandey, A., Shrestha, M.S., Sinisalo, A., Sutherland, C., and Williamson, P.

Published
2019

190. Fabrication and Characterization of Anticancer Drug Loaded Double Walled Microspheres

Author

Nagarajan, Elangovan, Rama, B, Swetha, M, Sharma, G.S, Jyothi Rani, L, Sudhamani, K, Nagarajan, Elangovan, Rama, B, Swetha, M, Sharma, G.S, Jyothi Rani, L, and Sudhamani, K

Abstract

In the present work, double walled microspheres of Tamoxifen (antiestrogenic drug) using Sodium alginate, Hydroxy propyl methyl cellulose (HPMC) K100,Guar gum, Xanthun gum were formulated to deliver Tamoxifen (TMX) through  oral route to treat breast cancer patients. Details regarding the preparation and evaluation of the formulations have been discussed in results. From the study following conclusions could be drawn. The results of this investigation indicate that Ion gelation method can be successfully employed to fabricate TMX microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Microspheres containing sodium alginate along with HPMC in 1:1 ratio had a least size range of 610µm. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size. The  invitro drug release decreased with increase in the polymer and copolymer concentration. Among all formulations F7 shows Maximum drug release in 12 th hr  when compared with other formulations. Analysis of drug release mechanism showed that the drug release from the formulations followed the Non fickian diffusion mechanism and follows zero order kinectics. Based on the results of evaluation tests formulation coded F7 was concluded as best formulation. Keywords : Tamoxifen, sodium alginate, HPMC, Microspheres, Diffusion, Copolymers,  Entrapment efficiency.

Published
2019

191. FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF BUSULFAN: USING COMBINATION OF pH AND TIME DEPENDANT SYSTEMS

Author

JAHNAVI, SAI, Sharma, GS, Rama, B, Jyothirani,, JAHNAVI, SAI, Sharma, GS, Rama, B, and Jyothirani,

Abstract

In present work Colon targeting drug delivery system was developed for Busulfan an anticancer drug by using combination of delayed systems one is pH dependant and other is time dependant delayed system.  Rapid release core tablet (RRCT) formulations were prepared using Busulfan drug with different disintegrating agents in different concentrations. The pre-compression and post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the In-vitro dissolution studies, F6 formulation with 12% Hydroxy propyl cellulose (HPC) was the best formulation. For optimized RRCT formulation press coat was done by using Xanthum Gum and Ethyl Cellulose (EC) in different ratios. Press coated tablet delays the drug release up to 8 hours based on the nature and concentrations of the polymer. Each press coated tablet was coated using enteric solution made of HPMC phthalate, Myvacet and color dissolved in ethanol. Enteric press coated tablets (EPCT) were delayed drug release up to 2hrs in fed condition due to pH dependant delayed system.  Based on dissolution studies of EPCT formulations, C3OPF formulation was optimized and showed delayed release pattern in a much customized manner. As a result of this study it may be concluded that the colon targeted drug delivery tablets using a combination of two polymers in optimized concentrations can be used to increase the delayed action of drug release to deliver the drug in a delayed manner. Key words: Colon, RRCT, HPC, Xanthum gum and EPCT

Published
2019

194. The Role of Clinical Pharmacists in the Emergency Department

Author

Natalija M. Farrell, Bryan D. Hayes, Rama B. Rao, Brenna M. Farmer, and Lewis S. Nelson

Subjects
medicine.medical_specialty, Medication Therapy Management, Health, Toxicology and Mutagenesis, education, MEDLINE, Staffing, Toxicology, Pharmacists, 03 medical and health sciences, Patient safety, 0302 clinical medicine, Professional Role, Medication therapy management, Medicine, Humans, 030212 general & internal medicine, Clinical care, Position Statement, business.industry, 030208 emergency & critical care medicine, Emergency department, medicine.disease, Clinical pharmacy, Patient population, Family medicine, Costs and Cost Analysis, Medical emergency, Patient Safety, business, Emergency Service, Hospital
Abstract

The ED is a unique setting with a diverse and complex patient population presenting around the clock with urgent and emergent needs. Emergency physicians readily utilize and value the presence of ED pharmacists to aid in this care [10, 52–54]. We support 24-h staffing of emergency departments with dedicated ED pharmacists as part of the clinical care team. ACMT also supports studies to further define the impact and value of pharmacists in the ED and other areas of ED expansion such as urgent care and observation units.

Published
2017

195. Design Optimization of a Bi-Fold Magnetorheological Damper Subject to Impact Loads

Author

Muftah Saleh, Rama B. Bhat, and Ramin Sedaghati

Subjects
Materials science, business.industry, Fold (geology), Magnetorheological damper, Structural engineering, business, Damper
Abstract

Dynamic range (ratio of the maximum on-state damping force to the off-state damping force), is an important index characteristic of the performance of the Magnetorheological Energy Absorbers (MREAs). In high speed impact, the dynamic range may fall into the uncontrollable zone (≤ 1) due to the increase in the off-state damping force which is associated with the transition of the flow from laminar to turbulent condition. Therefore, it is of paramount importance to design optimize the MREA in order to increase its dynamic range while accommodating the geometry, MR fluid flow and magnetic field constraints. In this study, a design optimization problem has been formulated to optimally design a bi-fold MREA to comply with the helicopter crashworthiness specifications for lightweight civilian helicopters. It is required to have a minimum dynamic range of 2 at 5 m/s impact velocity while satisfying the constraints imposed due to the geometry, volume of the device, magnetic field and the flow of the magnetorheological fluid in the MR valve. Meanwhile in order to comply with the helicopter crashworthiness requirement, the MREA device should be designed to generate 15 kN field-off damping force at the design impact velocity if the MREA is to be integrated with skid landing gear systems. The magneto-static analysis of the MREA valve has been conducted analytically using simplified assumptions in order to obtain the relation between induced magnetic flux in the MR fluid gaps in active regions versus the applied current and MREA valve geometrical parameters. Both Bingham plastic models, with and without minor loss factors, have been utilized to derive the dynamic range and the results are compared in terms of the generated off-state damping force, on-state damping force, and dynamic range. The Bingham plastic model with minor loss coefficients was found to be more accurate due to the turbulent condition in the MREA caused by the impact. Finally, the performance of the optimized bi-fold MREA has been evaluated under different impact speeds.

Published
2017
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196. Dealing with Tobacco Use among Youth: What Can Extension and Youth Professionals Do?

Author

Radhakrishna, Rama B. and Snider, B. Alan

Abstract

Survey responses from 8,634 seventh, eighth, and ninth graders in Pennsylvania (65%) found that 22% currently smoke; smokers are more likely to dislike school, have lower grades, think it acceptable to sell tobacco to minors, and be likely to smoke as adults; and nonsmokers were more likely to plan on college and believe second-hand smoke is hazardous. (SK)

Published
1997

197. Impact analysis due to multiple wheel flats in three-dimensional railway vehicle-track system model and development of a smart wheelset

Author

Rama B. Bhat, Waiz Ahmed, and Rajib Ul Alam Uzzal

Subjects
Engineering, Mathematical model, business.industry, Mechanical Engineering, Interface (computing), Fatigue damage, Structural engineering, Smart material, Track (rail transport), Automotive engineering, System model, Stress (mechanics), Development (differential geometry), business
Abstract

Wheel flats can create high-magnitude impact forces at the wheel/rail interface, these can induce high levels of local stress leading to fatigue damage, and failure of various vehicle and track components. With demands for increased load and speed levels, the issue of a strategy for effective maintenance and in-time replacement of defective wheel-flat-containing wheels has become an important concern for heavy haul operators. A comprehensive coupled vehicle/track model is generally used to predict the impact forces and the resulting component stresses in the presence of multiple flats. This paper considers the dynamic impact responses due to the presence of multiple flats. The characteristics of the bounce, pitch, and roll motions of the bogie due to a flat on a single wheel are investigated. The effect of multiple flats on the peak acceleration of a wheel is investigated for different sizes and relative positions of the flats, i.e. in-phase and out-of-phase conditions. This paper further presents the development of a smart wheelset for the detection of wheel flats for two different load conditions; it is based on a derived relationship between the peak wheel acceleration, vehicle speed and flat size.

Published
2014
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198. ANALYTICAL INVESTIGATIONS OF THE GRAVITY EFFECT ON THE DYNAMICS AND PERFORMANCE OF CENTRIFUGAL PENDULUM VIBRATION ABSORBER

Author

Rama B. Bhat, Ehab Abouobaia, and Ramin Sedaghati

Subjects
Vibration, Physics, Nonlinear system, Dynamic Vibration Absorber, Reciprocating motion, Rotor (electric), law, Pendulum, Vertical plane, Mechanics, Simple harmonic motion, law.invention
Abstract

Centrifugal Pendulum Vibration Absorber (CPVA) has been effectively used inrotating and reciprocating machines to control torsional vibrations passively. Thisresearch presents results from analytical investigation of rotor systems integratedwith CPVA. The system under investigation is modeled as a rotating disk attachedwith CPVA in which the disk is subjected to an external simple harmonic torque.Mathematical model of a rotor fitted with a CPVA has been formulated and theequations of motion are derived using Lagrange principle. The effect of gravity due toCPVA operating in a vertical plane with a horizontal shaft has been considered in theformulation. The results are also compared with those based on CPVA operating in ahorizontal plane in which the effect of gravity has been neglected. Moreover,softening nonlinear behavior of the pendulum and its effect on the natural frequencyof the system has been investigated.

Published
2014
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199. Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases

Author

Rama B. Bhat, Simona Badilescu, Nahum Sonenberg, Subhathirai Subramaniyan Parimalam, and Muthukumaran Packirisamy

Subjects
0301 basic medicine, Drug, Angiogenesis, media_common.quotation_subject, microfluidics, Drug Evaluation, Preclinical, Angiogenesis Inhibitors, Review, 02 engineering and technology, Models, Biological, Permeability, Catalysis, law.invention, Inorganic Chemistry, 03 medical and health sciences, Vasculogenesis, law, Lab-On-A-Chip Devices, Humans, Medicine, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, media_common, Brain Diseases, lab-on-a-chip, business.industry, Ischemic strokes, Organic Chemistry, Anti angiogenic, General Medicine, Human brain, Lab-on-a-chip, brain angiogenesis, 021001 nanoscience & nanotechnology, nanomedicines, Computer Science Applications, Nanomedicine, 030104 developmental biology, medicine.anatomical_structure, Blood-Brain Barrier, Angiogenesis Inducing Agents, Barrier permeability, 0210 nano-technology, business, Neuroscience
Abstract

There is a huge demand for pro-/anti-angiogenic nanomedicines to treat conditions such as ischemic strokes, brain tumors, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Nanomedicines are therapeutic particles in the size range of 10–1000 nm, where the drug is encapsulated into nano-capsules or adsorbed onto nano-scaffolds. They have good blood–brain barrier permeability, stability and shelf life, and able to rapidly target different sites in the brain. However, the relationship between the nanomedicines’ physical and chemical properties and its ability to travel across the brain remains incompletely understood. The main challenge is the lack of a reliable drug testing model for brain angiogenesis. Recently, microfluidic platforms (known as “lab-on-a-chip” or LOCs) have been developed to mimic the brain micro-vasculature related events, such as vasculogenesis, angiogenesis, inflammation, etc. The LOCs are able to closely replicate the dynamic conditions of the human brain and could be reliable platforms for drug screening applications. There are still many technical difficulties in establishing uniform and reproducible conditions, mainly due to the extreme complexity of the human brain. In this paper, we review the prospective of LOCs in the development of nanomedicines for brain angiogenesis–related conditions.

Published
2019
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