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As global warming continues, extreme precipitation events occur frequently in inland areas, seriously affecting human security and the ecological environment. Spatiotemporal evolution of extreme precipitation as well as response of extreme precipitation to climatic warming and its mechanism were investigated by considering the Weihe river basin in a monsoon transition zone of China as a research object. The results indicate that while the annual average temperature of the Weihe river basin increased with fluctuations from 1966 to 2017, except for the consecutive dry days (CDD) and simple daily intensity index that increased slightly, the other extreme precipitation indices (consecutive wet days, R25, and Rx5day) tended to decrease. Moreover, except for the CDD, the other four indices gradually increased from the northwest to the southeast, showing a similar trend to the temperature. The relationship between the 95th percentile threshold and temperature (hereinafter referred to as the P 95d–T relationship) in the Weihe river basin demonstrates the hook structure and its strength in terms of response is mainly dominated by the super-Clausius–Clapeyron (C–C) and C–C scaling. Furthermore, the peak temperature rises gradually from the northwest to the southeast. The results can provide important reference for the prediction of climate change and future studies of disaster risk in the Weihe river basin.

To evaluate the role of serum human epididymis secretory protein 4 (HE4) and carbohydrate antigen 125 (CA125) levels for predicting and monitoring the recurrence of endometrial endometrioid carcinoma (EEC) and assessing preoperative risk stratification in EEC patients. A total of 434 EEC patients were selected for this retrospective study between May 2011 and August 2018. Serum HE4 and CA125 levels were analyzed before the initial treatment, at the first postoperative follow-up, and at recurrence or the last follow-up. Patients were risk stratified according to the European Society for Medical Oncology (ESMO), European Society for Radiotherapy & Oncology (ESTRO) and European Society of Gynaecological Oncology (ESGO) guideline. We compared the ability of these biomarkers for prediction and monitoring by performing receiver operating characteristic curve analysis and identified optimal cut-off values by determining the Youden index. Kaplan-Meier analyses were also performed to determine prognostic value. Preoperative serum HE4 was identified as a significant predictor for the recurrence of EEC (p = 0.014). Preoperative serum HE4 and CA125 levels were related to depth of myometrial invasion, lymph node status and FIGO stage. Serum HE4 and CA125 levels were both statistically significant markers for monitoring the recurrence of EEC (P = 0.000 for each biomarker). When combined, the two markers showed higher levels of sensitivity and specificity. The two biomarkers were also significant biomarkers for evaluating the risk stratification of patients undergoing lymphadenectomy (P = 0.000 for each biomarker). For premenopausal stage I patients, preoperative serum HE4 and CA125 levels were significant predictors of the need for ovarian preservation (P = 0.000 and P = 0.002, respectively). For premenopausal patients with stage I intramucosal differentiation, preoperative serum levels of HE4 were significant predictors for fertility preservation (P = 0.024). Preoperative serum HE4 level can be used to predict the recurrence of EEC. Postoperative serum HE4 and CA125 levels can be used to monitor the recurrence of EEC and are more sensitive when combined. Preoperative serum levels of CA125 and HE4 levels are of significant value for risk stratification in EEC patients.

The interaction between vector beams and atoms under a weak magnetic field could induce spatially dependent electromagnetically induced transparency (EIT). Based on such a coherence effect, we propose a method for manipulating vector beams carrying spiral varying phases in hot rubidium atoms. When a transverse magnetic field (TMF) is applied, the transparent regions of the transmitted beam are strongly depend on the beam’s polarization distribution. In addition to the intensity modulation, the alignment of the TMF is reflected in the rotation of the central symmetric transmission patterns. In theory, we discuss the physical mechanism of the spiral EIT region generated by the phase profile, and analyze the influence of system parameters on this coherent process. Our work confirms that introducing additional radial phases can also lead to spatially dependent EIT, which extends another degree of freedom to manipulate atomic polarization. This will provide potential applications in light field manipulation and multi-dimensional quantum storage.

Abstract Quantum incompatibility is a fundamental property in quantum physics and is considered as a resource in quantum information processing tasks. Here, we construct a framework based on the incompatibility witness originated from quantum state discrimination. In this framework, we discuss the geometrical properties of the witnesses with noisy mutually unbiased bases and construct a quantifier of quantum incompatibility associated with geometrical information. Furthermore, we explore the incompatibility of a pair of positive operator valued measurements, which only depends on the information of measurements, and discuss the incompatibility of measurements which can be discriminated by mutually unbiased bases. Finally, if we take a resource-theory perspective, the new-defined quantifier can characterize the resource of incompatibility. This geometrical framework gives the evidence that vectors can be utilized to describe resourceful incompatibility and make a step to explore geometrical features of quantum resources.

Objective To investigate the significance of transcription factor LIM domain only 3 (LMO3) expression level in the prognosis of patients with endometrial carcinoma (EC). Methods The Cancer Genome Atlas (TCGA), GeneMANIA and STRING databases were used to analyze the relationship between LMO3 expression in EC tissues and the prognosis of patients, as well as the genes interacting with LMO3, and the correlation of LMO3 with TP53 mutation. The paraffin sections and clinical information of 51 patients with EC who underwent surgery in our hospital from March 2011 to December 2014 were collected. Immunohistochemical staining was subsequently performed to determine the expression of LMO3 in EC tissues and its association with the clinicopathological features of patients. SPSS was used to plot the survival curve, and COX multivariate regression analysis was also adopted. In addition, LMO3 overexpression was conducted in EC cells to verify its effect on tumor cell migration. Results According to the analysis of TCGA database, the overall survival and disease-free survival of patients with high LMO3 expression were significantly shorter than those of low LMO3 expression(P < 0.05), and the expression level of LMO3 in patients with TP53 mutation was remarkably higher than that in TP53 wild-type patients. GeneMANIA and STRING analyses showed that the main genes interacting with LMO3 included NHLH2 and LDB2. Moreover, immunohistochemical staining also indicated that patients with higher LMO3 expression level had shorter disease-free survival (P=0.005), and multivariate COX analysis suggested LMO3 as a prognostic factor for EC. Finally, overexpression of LMO3 enhanced the migration of EC cells. Conclusion EC patients with high LMO3 level have a poor prognosis, which may be related to the migration of EC cells promoted by LMO3 overexpression.