1,340 results on '"QUN LUO"'
Search Results
152. PCR- Negative Atypical PML-RARA Rearrangement in Pediatric Acute Promyelocytic Leukemia
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Dan-Ping Huang, Yi-Jun Chen, Jie-Si Luo, Shao-Qian Chen, Jing Cheng, Yu Li, Cong Liang, Li-Na Wang, Zhong Fan, Xiao-Li Zhang, Xue-Qun Luo, Li-Bin Huang, and Yan-Lai Tang
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immune system diseases ,hemic and lymphatic diseases ,neoplasms - Abstract
Acute promyelocytic leukemia (APL) is a special type of acute myeloid leukemia (AML), accounting for about 5% to 10% of children with AML. At the genetic level, APL is featured by a unique chromosome translocation t(15;17) which results in the PML-RARA gene fusion. Most patients can be diagnosed by traditional karyotype analysis, Fluorescence-In-Situ Hybridization (FISH), or Reverse Transcription-Polymerase Chain Reaction (RT-PCR). We report the case of a child with acute promyelocytic leukemia (APL) who had characteristic chromosome translocation t(15;17) and rare PML-RARA gene mutation. This patient had an excellent response to chemotherapy, suggesting that this mutation will not affect the treatment and prognosis of APL.
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- 2021
153. Enhanced grain refinement of Al-Si alloys by novel Al-V-B refiners
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Qian Li, Chenxi Zhao, Qiling Xiao, Ying Jiang, Yang Li, Xu Jin, and Qun Luo
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Work (thermodynamics) ,Materials science ,Polymers and Plastics ,Mechanical Engineering ,Alloy ,Metals and Alloys ,Nucleation ,Thermodynamics ,02 engineering and technology ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Surface energy ,Grain size ,0104 chemical sciences ,Mechanics of Materials ,Materials Chemistry ,Ceramics and Composites ,engineering ,Particle ,Density functional theory ,0210 nano-technology ,Refining (metallurgy) - Abstract
Al-V-B master alloy is promising for refining Al-Si alloys, yet its optimal composition with superior efficacy remains to be explored. In this work, the evolution of refining phases in the Al-10Si/Al-V-B system with different V:B ratios was evaluated by thermodynamic calculations, based on which the Al-V-B refiners with V:B = 1:1 and 5:1 were designed. Refining trails demonstrated that they could significantly reduce the grain size of Al-10Si (wt.%) alloy from 1736 to 184–245 μm with industrial addition amount. Detailed examinations results clarify that when V:B ratio is 1:1 the nucleation particle is (V,Al)B2, which has a VB2-AlB2 core-shell structure and therefore presents the nucleation capability as AlB2 particle. When V:B ratio is as high as 5:1, the nucleation particle is pure VB2. Density functional theory (DFT) calculation indicates that (0 0 0 1) VB2/(1 1 1) α-Al interface has the lowest interfacial energy such that highest nucleation potency among other types of diboride/α-Al interfaces under consideration. The outcomes of this work provide fundamental guidance to develop superior V-B based refiners for Al-Si alloys.
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- 2021
154. MicroRNA-506 has a suppressive effect on the tumorigenesis of nonsmall-cell lung cancer by regulating tubby-like protein 3
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Zhan-Hua Li, Ji-Hong Zhou, Si-Ning Chen, Ling Pan, Yuan Feng, Mei-Qun Luo, Rui-Xiang Li, and Gui-Li Sun
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Lung Neoplasms ,Carcinogenesis ,Cell Survival ,Apoptosis ,Bioengineering ,mitochondrial apoptosis ,tubby-like protein 3 ,Applied Microbiology and Biotechnology ,Mice ,Carcinoma, Non-Small-Cell Lung ,Cell Line, Tumor ,Animals ,Humans ,Gene Silencing ,Cell Proliferation ,Intracellular Signaling Peptides and Proteins ,nonsmall-cell lung cancer ,General Medicine ,Xenograft Model Antitumor Assays ,Mitochondria ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,microrna-506 ,Disease Progression ,TP248.13-248.65 ,Research Article ,Research Paper ,Biotechnology - Abstract
MicroRNA-506 (miR-506), a miRNA, has been proven to act as a tumor suppressor gene in nonsmall-cell lung cancer (NSCLC); Tubby-like protein 3 (TULP3) is a potential target gene of miR-506. This study investigates whether miR-506 can prevent NSCLC progression by mediating TULP3. In vivo and in vitro experiments were performed to explore the function and potential regulatory relationship of miR-506 and TULP3 in NSCLC. Our results revealed that miR-506 is high expression in NSCLC cell lines, and the overexpression of miR-506 could inhibit cell viability and enhance cell apoptosis in H1299 and A549 cells. Pro-apoptotic related protein (cytochrome C, Bax, and cleaved caspase-9) expression increased while anti-apoptotic related protein (BCL-2 and BCL-XL) expression decreased after miR-506 was overexpression. Meanwhile, the overexpression of miR-506 could notably downregulate TULP3. Additionally, silence of TULP3 inhibited cell viability and promoted cell apoptosis. At the same time, pro-apoptotic related protein expression was promoted while anti-apoptotic related protein expression was inhibited. Furthermore, TULP3 overexpression could markedly reverse the inhibitory effect of miR-506 on the proliferation and induction of mitochondrial apoptosis in H1299 and A549 cells. In vivo tumor formation experiments also exhibited consistent results indicating that the functions of TULP3 might be correlated with the promotion of tumorigenesis. In conclusion, we firstly found that miR-506 can be involved in the processes of NSCLC and exert a suppressive effect on tumorigenesis by regulating TULP3 expression.
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- 2021
155. Controllable Photoelectric Properties of Carbon Dots and Their Application in Organic Solar Cells
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Bingshe Xu, Lingpeng Yan, Zhao Wensheng, Yongzhen Yang, Hua Wang, Han Zha, Xuguang Liu, Chang-Qi Ma, Qun Luo, and Xin-Xin Li
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Materials science ,Polymers and Plastics ,Organic solar cell ,business.industry ,General Chemical Engineering ,Organic Chemistry ,Energy conversion efficiency ,chemistry.chemical_element ,Photoelectric effect ,Surface energy ,Active layer ,Roll-to-roll processing ,chemistry ,Optoelectronics ,business ,Layer (electronics) ,Carbon - Abstract
Organic solar cells are a current research hotspot in the energy field because of their advantages of lightness, translucency, roll to roll printing and building integration. With the rapid development of small molecule acceptor materials with high-performance, the efficiency of organic solar cells has been greatly improved. Further improving the device efficiency and stability and reducing the cost of active layer materials will contribute to the industrial development of organic solar cells. As a novel type of carbon nanomaterials, carbon dots gradually show great application potential in the field of organic solar cells due to their advantages of low preparation cost, non-toxicity and excellent photoelectric performance. Firstly, the synthesis and classification of carbon dots are briefly introduced. Secondly, the photoelectric properties of carbon dots and their adjusting, including adjustable surface energy level structure, good film-forming performance and up/down conversion characteristics are summarized. Thirdly, based on these intrinsic properties, the feasibility and advantages of carbon dots used in organic solar cells are discussed. Fourthly, the application progress of carbon dots in the active layer, hole transport layer, electron transport layer, interface modification layer and down-conversion materials of organic solar cells is also reviewed. Finally, the application progress of carbon dots in organic solar cells is prospected. Several further research directions, including in-depth exploration of the controllable preparation of carbon dots and their application in the fields of interface layer and up/down conversion for improving efficiency and stability of device are pointed out.
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- 2021
156. Thermodynamics and kinetics of hydriding and dehydriding reactions in Mg-based hydrogen storage materials
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Shuhui Sun, Zhihua Dong, Yuan Chen, Bin Jiang, Jie Dang, Jun Tan, Yan Yang, Yangfan Lu, Xiaohua Yang, Jianbo Li, Qun Luo, Qian Li, and Fusheng Pana
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Mining engineering. Metallurgy ,Materials science ,Kinetic models ,Hydrogen ,Enthalpy ,Composite number ,Kinetics ,TN1-997 ,Metals and Alloys ,Thermodynamics ,chemistry.chemical_element ,Hydrogen storage ,chemistry ,Mechanics of Materials ,Analysis methods ,Dehydrogenation ,Hydriding/dehydriding reactions ,Magnesium-based hydrogen storage materials - Abstract
Mg-based materials are one of the most promising hydrogen storage candidates due to their high hydrogen storage capacity, environmental benignity, and high Clarke number characteristics. However, the limited thermodynamics and kinetic properties pose major challenges for their engineering applications. Herein, we review the recent progress in improving their thermodynamics and kinetics, with an emphasis on the models and the influence of various parameters in the calculated models. Subsequently, the impact of alloying, composite, and nano-crystallization on both thermodynamics and dynamics are discussed in detail. In particular, the correlation between various modification strategies and the hydrogen capacity, dehydrogenation enthalpy and temperature, hydriding/dehydriding rates are summarized. In addition, the mechanism of hydrogen storage processes of Mg-based materials is discussed from the aspect of classical kinetic theories and microscope hydrogen transferring behavior. This review concludes with an outlook on the remaining challenge issues and prospects.
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- 2021
157. In situ performance and stability tests of large-area flexible polymer solar cells in the 35-km stratospheric environment
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Zihan Xu, Guoning Xu, Qun Luo, Yunfei Han, Yu Tang, Ying Miao, Yongxiang Li, Jian Qin, Jingbo Guo, Wusong Zha, Chao Gong, Kun Lu, Jianqi Zhang, Zhixiang Wei, Rong Cai, Yanchu Yang, Zhaojie Li, and Chang-Qi Ma
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Multidisciplinary - Abstract
Flexible organic solar cells (FOSCs) are one of the most promising power sources for aerospace aircraft due to their attractive advantages with high power-per-weight ratio and excellent mechanical flexibility. Understanding the performance and stability of high-performance FOSCs is essential for the further development of FOSCs for aerospace applications. In this paper, after systematic investigations on the performance of the state-of-the-art high-performance solar cells under thermal cycle and intensive UV irradiation conditions, in situ performance and stability tests of the solar cells in the 35 km stratospheric environment were carried out through a high-altitude balloon uploading. The encapsulated FOSCs with an area of 0.64 cm2 gave the highest power density of 15.26 mW/cm2 and an efficiency over 11%, corresponding to a power-per-weight ratio of over 3.32 kW/kg. More importantly, the cells showed stable power output during the 3-h continuous flight at 35 km and only 10% performance decay after return to the lab, suggesting promising stability of the FOSCs in the stratospheric environment.
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- 2022
158. Over 31% efficient indoor organic photovoltaics enabled by simultaneously reduced trap-assisted recombination and non-radiative recombination voltage loss
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Xiaobo Zhou, Hongbo Wu, Urvashi Bothra, Xingze Chen, Guanyu Lu, Heng Zhao, Chao Zhao, Qun Luo, Guanghao Lu, Ke Zhou, Dinesh Kabra, Zaifei Ma, and Wei Ma
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Mechanics of Materials ,Process Chemistry and Technology ,General Materials Science ,Electrical and Electronic Engineering - Abstract
Indoor organic photovoltaics (OPVs) have shown great potential application in driving low-energy-consumption electronics for the Internet of Things. There is still great room for further improving the power conversion efficiency (PCE) of indoor OPVs, considering that the desired morphology of the active layer to reduce trap-assisted recombination and voltage losses and thus simultaneously enhance the fill factor (FF) and open-circuit voltage for efficient indoor OPVs remains obscure. Herein, by optimizing the bulk and interface morphology
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- 2022
159. Chiral nanocrystals grown from MoS2 nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs
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Bang Lin Li, Jun Jiang Luo, Hao Lin Zou, Qing-Meng Zhang, Liu-Bin Zhao, Hang Qian, Hong Qun Luo, David Tai Leong, and Nian Bing Li
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Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
The transfer of the concept of chirality from molecules to synthesized nanomaterials has attracted attention amongst multidisciplinary teams. Here we demonstrate heterogeneous nucleation and anisotropic accumulation of Au nanoparticles on multilayer MoS2 planes to form chiroptically functional nanomaterials. Thiol amino acids with chiral conformations modulate asymmetric growth of gold nanoarchitectures on seeds of highly faceted Au/MoS2 heterostructures. Consequently, dendritic plasmonic nanocrystals with partial chiral morphologies are synthesized. The chirality of dendritic nanocrystals inherited from cysteine molecules refers to the structural characteristics and includes specific recognition of enantiomeric molecules. With integration of the intrinsic photothermal properties and inherited enantioselective characteristics, dendritic Au/MoS2 heterostructures exhibit chirality-dependent release of antimicrobial drugs from hydrogel substrates when activated by exogenous infrared irradiation. A three-in-one strategy involving synthesis of chiral dendritic heterostructures, enantioselective recognition, and controlled drug release system is presented, which improves nanomaterial synthetic technology and enhances our understanding of crucial chirality information.
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- 2022
160. The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1
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Wei, Huang, Yu-Meng, Sun, Qi, Pan, Ke, Fang, Xiao-Tong, Chen, Zhan-Cheng, Zeng, Tian-Qi, Chen, Shun-Xin, Zhu, Li-Bin, Huang, Xue-Qun, Luo, Wen-Tao, Wang, and Yue-Qin, Chen
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Genetics ,Cell Biology ,Molecular Biology ,Biochemistry - Abstract
Long noncoding RNAs (lncRNAs) are usually 5′ capped and 3′ polyadenylated, similar to most typical mRNAs. However, recent studies revealed a type of snoRNA-related lncRNA with unique structures, leading to questions on how they are processed and how they work. Here, we identify a novel snoRNA-related lncRNA named LNC-SNO49AB containing two C/D box snoRNA sequences, SNORD49A and SNORD49B; and show that LNC-SNO49AB represents an unreported type of lncRNA with a 5′-end m7G and a 3′-end snoRNA structure. LNC-SNO49AB was found highly expressed in leukemia patient samples, and silencing LNC-SNO49AB dramatically suppressed leukemia progression in vitro and in vivo. Subcellular location indicated that the LNC-SNO49AB is mainly located in nucleolus and interacted with the nucleolar protein fibrillarin. However, we found that LNC-SNO49AB does not play a role in 2′-O-methylation regulation, a classical function of snoRNA; instead, its snoRNA structure affected the lncRNA stability. We further demonstrated that LNC-SNO49AB could directly bind to the adenosine deaminase acting on RNA 1(ADAR1) and promoted its homodimerization followed by a high RNA A-to-I editing activity. Transcriptome profiling shows that LNC-SNO49AB and ADAR1 knockdown respectively share very similar patterns of RNA modification change in downstream signaling pathways, especially in cell cycle pathways. These findings suggest a previously unknown class of snoRNA-related lncRNAs, which function via a manner in nucleolus independently on snoRNA-guide rRNA modification. This is the first report that a lncRNA regulates genome-wide RNA A-to-I editing by enhancing ADAR1 dimerization to facilitate hematopoietic malignancy, suggesting that LNC-SNO49AB may be a novel target in therapy directed to leukemia.
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- 2022
161. Corrosion-Engineered Mo-Containing FeCo-(oxy)hydroxide Electrocatalysts for Superior Oxygen Evolution Reaction
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Juan Luo, Xiao Hui Chen, Nian Bing Li, Li Shen, Qing Zhang, Hong Qun Luo, Xiao Hu Wang, Li Li Wu, and Hong Chuan Fu
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chemistry.chemical_compound ,Materials science ,Chemical engineering ,chemistry ,Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Oxygen evolution ,Environmental Chemistry ,Hydroxide ,General Chemistry ,Corrosion - Published
- 2021
162. The Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment
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Hong Xu, Qianwen Huang, Yingqi Nong, Yan-Qun Luo, Xiqian Zhang, Li-Jia Zhang, Xiu-Lan Zhu, Wen-Juan Liu, Li Yao, and Fenghua Liu
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Adult ,Time Factors ,Pregnancy Rate ,high-quality embryos ,Pharmaceutical Science ,Stimulation ,Controlled ovarian hyperstimulation ,Group A ,Andrology ,Follicle-stimulating hormone ,Follicle ,follicle distribution on hCG day ,Ovarian Follicle ,Ovulation Induction ,Pregnancy ,Drug Discovery ,Medicine ,Humans ,Clinical efficacy ,follicle-stimulating hormone ,Gn stimulation duration ,Original Research ,Retrospective Studies ,Pharmacology ,Drug Design, Development and Therapy ,Dose-Response Relationship, Drug ,business.industry ,Embryo ,Treatment Outcome ,Oocytes ,Female ,follicle growth rate ,Follicle Stimulating Hormone ,business ,Hormone - Abstract
Xi-Qian Zhang,* Li-Jia Zhang,* Xiu-Lan Zhu, Hong Xu, Yan-Qun Luo, Li Yao, Qian-Wen Huang, Ying-Qi Nong, Wen-Juan Liu, Feng-Hua Liu Reproductive Medical Center, Guangdong Women and Children Hospital, Guangzhou, 511442, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Feng-Hua LiuDepartment of Reproductive Medical Center, Guangdong Women and Children Hospital, No. 521 Xingnan Road, Panyu District, Guangzhou, 511442, Guangdong Province, Peopleâs Republic of ChinaTel +86 20-3915 1861Fax +86 20-3915 1617Email liufenghua377@21cn.comObjective: To compare the use and clinical efficacy of three different follicle-stimulating hormones (FSHs) for follicle growth and development in long-protocol controlled ovarian hyperstimulation (COH).Methods: A total of 540 gonadotropin-releasing hormone (GnRH) agonistsâ long protocol treatment cycles at our hospital between January 2015 and May 2020 and met the inclusion criteria were retrospectively analyzed. The cycles were divided into three groups based on their indexes (groups A, B, and C). Each of the groups received a different type of FSH during treatment. A cross-group comparison was then undertaken to evaluate the growth and development of the three largest follicles and the patientsâ pregnancy-related indexes between the normal-response and high-response populations.Results: In the normal-response populations, the number of high-quality embryos obtained in groups A and B was significantly higher than in group C, and the FSH dosage was significantly lower than in group C (P < 0.05). There were more follicles with a diameter of 16â 18 mm found in group A than in group C on the day of hCG injection (hCG day) (P < 0.05), but there were no significant differences in the groups in other indicators. In the high-response populations, the number of oocytes retrieved and high-quality embryos obtained in group A were significantly higher than in group C (P < 0.05), and the total dosage and duration of FSH stimulation in group C were significantly higher than groups A and B (P < 0.05).Conclusion: Three different types of FSH led to comparable growth rates of the three largest follicles and clinical pregnancy rates per fresh cycle in long-protocol COH treatment.Keywords: follicle-stimulating hormone, follicle growth rate, high-quality embryos, Gn stimulation duration, follicle distribution on hCG day
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- 2021
163. Influence of Natural Fractures on Tight Oil Migration and Production: A Case Study of Permian Lucaogou Formation in Jimsar Sag, Junggar Basin, NW China
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Quanqi Dai, Qun Luo, Lianbo Zeng, Shouxu Pan, Dongdong Liu, Yunzhao Zhang, Wenya Lyu, and Rukai Zhu
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Tectonics ,Bedding ,Permian ,Outcrop ,Stylolite ,Tight oil ,General Earth and Planetary Sciences ,Structural basin ,Petrology ,Geology ,Diagenesis - Abstract
Natural fractures, as the main flow channels and important storage spaces, have significant effects on the migration, distribution, and accumulation of tight oil. According to outcrop, core, formation micro image (FMI), cast-thin-section, and scanning electron microscopy data from the tight reservoir within the Permian Lucaogou Formation of the Junggar Basin, tectonic fractures are prevalent in this formation mainly on micro to large scale. There are two types of fractures worth noticing: diagenetic fractures and overpressure-related fractures, primarily at micro to medium scale. The diagenetic fractures consist of bedding fractures, stylolites, intragranular fractures, grain-boundary fractures, and diagenetic shrinkage fractures. Through FMI interpretation and Monte Carlo method evaluation, the macro-fractures could be considered as migration channels, and the micro-fractures as larger pore throats that function as storage spaces. The bedding fractures formed earlier than all tectonic fractures, while the overpressure-related fractures formed in the Middle and Late Jurassic. The bedding fractures and stylolites function as the primary channels for horizontal migration of tight oil. The tectonic fractures can provide vertical migration channels and reservoir spaces for tight oil, and readjust the tight oil distribution. The overpressure-related fractures are fully filled with calcite, and hence, have little effect on hydrocarbon migration and storage capacity. The data on tight oil production shows that the density and aperture of fractures jointly determine the productivity of a tight reservoir.
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- 2021
164. Influence of Fine Particle Content to Sediment Transport
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Min, Zhang, Hua-Qin, Wu, Li-qun, Luo, and Wan, Xiaofeng, editor
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- 2011
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165. Boosting Perovskite Solar Cells Efficiency and Stability: Interfacial Passivation of Crosslinked Fullerene Eliminates the 'Burn-in' Decay
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Changzeng Ding, Li Yin, Jinlong Wang, Valentina Larini, Lianping Zhang, Rong Huang, Mathias Nyman, Liyi Zhao, Chun Zhao, Weishi Li, Qun Luo, Yanbin Shen, Ronald Österbacka, Giulia Grancini, and Chang‐Qi Ma
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Abstract
Perovskite solar cells (PSCs) longevity is nowadays the bottleneck for their full commercial exploitation. Although lot of research is ongoing, the initial decay of the output power - an effect known as "burn-in" degradation happening in the first 100 h - is still unavoidable, significantly reducing the overall performance (typically of20%). In this paper, the origin of the "burn-in" degradation in n-i-p type PSCs is demonstrated that is directly related to Li
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- 2022
166. Negative thermal expansion and phase transition of low-temperature Mg2NiH4
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Qun Luo, Qi Cai, Qinfen Gu, Yu Shi, Bin Liu, Xuan Quy Tran, Syo Matsumura, Tong-Yi Zhang, Kazuhiro Nogita, Tao Lyu, Qian Li, and Fusheng Pan
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Mechanics of Materials ,Metals and Alloys - Published
- 2022
167. Comprehensive Analysis of Fibroblast Activation Protein (FAP) Expression in Interstitial Lung Diseases (ILDs)
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Penghui Yang, Qun Luo, Xinlu Wang, Qi Fang, Zhenli Fu, Jia Li, Yunxin Lai, Xiaobo Chen, Xin Xu, Xiaomin Peng, Kongzhen Hu, Xiaowei Nie, Shaoyu Liu, Jinhe Zhang, Junqi Li, Chenyou Shen, Yingying Gu, Jianping Liu, Jingyu Chen, Nanshan Zhong, and Jin Su
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Pulmonary and Respiratory Medicine ,Critical Care and Intensive Care Medicine - Abstract
Sustained activation of lung fibroblasts and the resulting over-synthesis of the extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs). Lung biopsy is a primary evaluation technique for the fibrotic status of ILDs, which is a major risk factor for triggering acute deterioration. Fibroblast activation protein (FAP) is a long-known surface biomarker of activated fibroblasts, but its expression pattern and diagnostic implications in ILDs are poorly defined.The present study aims to comprehensively investigate whether the expression intensity of FAP could be used as a potential readout to estimate/measure the amounts of activated fibroblasts in ILD lungs quantitatively.FAP expression in human primary lung fibroblasts as well as in clinical lung specimens was firstly tested using multiple experimental methods, including qPCR, western blot, immunofluorescence staining, deep learning measurement of whole slide immunohistochemistry as well as single-cell sequencing. In addition, FAP-targeted PET/CT imaging was applied to various types of ILD patients, and the correlation between the uptake of FAP tracer and pulmonary function parameters was analyzed.Here, it was revealed, for the first time, that FAP expression was upregulated significantly in the early phase of lung fibroblast activation event in response to a low dose of pro-fibrotic cytokine. Single-cell sequencing data further indicate that nearly all FAP-positive cells in ILD lungs were collagen-producing fibroblasts. Immunohistochemical analysis validated that FAP expression level was closely correlated with the abundance of fibroblastic foci on human lung biopsy sections from patients with ILDs. We found that the total uptake of FAPI PET tracer (FAPI SUVtotal) was significantly related to lung function decline in ILD patients.Our results strongly support that in vitro and in vivo detection of FAP can assess the pro-fibrotic activity of ILDs, which may aid in early diagnosis and the selection of an appropriate therapeutic window. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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- 2022
168. Mechanism of Fe removal by Sn addition in Al-7Si-1Fe alloy
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Qun Luo, Meng Cong, Hongxia Li, Longfei Zhu, Hongcan Chen, and Qian Li
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Mechanics of Materials ,Mechanical Engineering ,Materials Chemistry ,Metals and Alloys - Published
- 2023
169. A photoelectrochemical biosensor based on ZnIn2S4@AuNPs coupled with circular bipedal DNA walker for signal-on detection of circulating tumor DNA
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Ya Bin Cui, Hang Yan, Zhe Sun, Yu Ling, Hong Qun Luo, and Nian Bing Li
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Electrochemistry ,Biomedical Engineering ,Biophysics ,General Medicine ,Biotechnology - Published
- 2023
170. Modulating the interfacial built-in electric field in oxygen vacancies-enriched Ru/MxOy@C (M = V, Nb, Ta) ordered macroporous heterojunctions for electrocatalytic hydrogen production
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Xiao Hui Chen, Hong Chuan Fu, Xiao Lin Li, Ting Li, Qing Zhang, Zi Qing Li, Yuan Hao Luo, Jing Lei Lei, Nian Bing Li, and Hong Qun Luo
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
171. Effect of topological structure on the supercapacitive performance of redox-active triblock copolymers electrode-based asymmetric supercapacitors
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Xueyi Chang, Yongfu Qiu, Zhiyu Cheng, Qun Luo, Guiping Tan, and Biye Ren
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Inorganic Chemistry ,Organic Chemistry ,Materials Chemistry ,Physical and Theoretical Chemistry ,Biochemistry - Published
- 2023
172. Boosting the photovoltaic performance of doctor-bladed organic solar cells using a low-boiling solvent additive
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Xue Bai, Erming Feng, Hengyue Li, Jingbo Guo, Xiaoming Yuan, Huan Liu, Qun Luo, Yingguo Yang, Changqi Ma, Chenyi Yi, Zijian Zheng, and Junliang Yang
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Biomaterials ,Materials Chemistry ,General Chemistry ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2023
173. Cascade reaction-based highly sensitive fluorescent sensing systems applicable for dual-pattern fluorescence visualizing of thiophenol flavors in meat products and condiments
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Zi Yi, Xu, Xiao Hu, Wang, Hong Qun, Luo, and Nian Bing, Li
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General Medicine ,Food Science ,Analytical Chemistry - Abstract
Thiophenols (ArSHs) are widely used as popular flavoring ingredients for making daily dishes. Dissecting the ArSHs contents in common foodstuffs is meaningful in the field of food safety science. Herein, a novel small-molecule sensor 2-(1H-benzo[d]imidazol-2-yl)-3-(2-(2,4-dinitrophenoxy)-4-morpholinophenyl)acrylonitrile (NOSA) has been tailored. The NOSA is able to respond to ArSHs, spontaneously yielding highly green-emissive fluorescent iminocoumarin (I
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- 2023
174. Screening of aggregation-induced emission and multi-response acrylonitrile-bridging fluorescent molecules tailored for rapid turn-on detection of HClO as well as ratiometric visualizing of extreme basicity
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Zi Yi Xu, Li Meng, Hong Qun Luo, Qi Xiao, and Nian Bing Li
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Environmental Chemistry ,Biochemistry ,Spectroscopy ,Analytical Chemistry - Published
- 2023
175. An Efficient Remote User Authentication Scheme with Strong Anonymity.
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Yanfei Liu, Ziming Zhao 0001, Hui Li 0070, Qun Luo, and Yixian Yang
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- 2008
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176. Regulation of the IGF1 signaling pathway is involved in idiopathic pulmonary fibrosis induced by alveolar epithelial cell senescence and core fucosylation
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Jian Guo, Na Wang, Wei Sun, Ping Wang, Qian Zhang, Zuojun Xu, Xiaoyan Jing, Hui Huang, Qun Luo, Shu Xia, and Xiaoyu Yang
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Male ,Senescence ,endocrine system ,Aging ,education ,core fucosylation ,Bleomycin ,Mice ,Phosphatidylinositol 3-Kinases ,Idiopathic pulmonary fibrosis ,Pulmonary fibrosis ,medicine ,Animals ,Humans ,Insulin-Like Growth Factor I ,alveolar epithelial cell ,Protein kinase B ,Cellular Senescence ,PI3K/AKT/mTOR pathway ,Aged ,Akt/PKB signaling pathway ,business.industry ,Cell Biology ,respiratory system ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,respiratory tract diseases ,Mice, Inbred C57BL ,CTGF ,Disease Models, Animal ,IPF ,Alveolar Epithelial Cells ,IGF-1 ,Cancer research ,Female ,Signal transduction ,business ,Proto-Oncogene Proteins c-akt ,hormones, hormone substitutes, and hormone antagonists ,Signal Transduction ,Research Paper - Abstract
Idiopathic pulmonary fibrosis (IPF) mainly occurs in elderly people over the age of sixty. IPF pathogenesis is associated with alveolar epithelial cells (AECs) senescence. Activation of PI3K/AKT signaling induced by insulin-like growth factor 1 (IGF1) participates in AEC senescence and IPF by releasing CTGF, TGF-β1, and MMP9. Our previous study demonstrated that core fucosylation (CF) modification, catalyzed by a specific core fucosyltransferase (FUT8) can regulate the activation of multiple signaling pathways, and inhibiting CF can alleviate pulmonary fibrosis in mice induced by bleomycin. However, whether CF is involved in IGF1-mediated AEC senescence in IPF remains unclear. In this study, we found that the IGF1/PI3K/AKT signaling pathway was activated in IPF lung tissue. Meanwhile, CF was present in senescent AECs. We also showed that IGF1 could induce AECs senescence with enhanced CF in vivo and in vitro. Inhibiting CF alleviated AECs senescence and pulmonary fibrosis induced by IGF1. In addition, activation of IGF1/PI3K/AKT signaling depends on CF. In conclusion, this study confirmed that CF is an important target regulating the IGF1 signaling pathway in AEC senescence and IPF, which might be a candidate target to treat IPF in the future.
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- 2021
177. Layer-by-layer slot-die coated high-efficiency organic solar cells processed using twin boiling point solvents under ambient condition
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Yu Yang, Hengyue Li, Wanrong Liu, Zichao Shen, Guanghao Lu, Junliang Yang, Jingbo Guo, Erming Feng, Qun Luo, Jidong Zhang, and Chang-Qi Ma
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Nanostructure ,Materials science ,Organic solar cell ,Layer by layer ,Energy conversion efficiency ,engineering.material ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Polymer solar cell ,Boiling point ,Coating ,Chemical engineering ,engineering ,General Materials Science ,Electrical and Electronic Engineering ,Thin film - Abstract
Layer-by-layer (LbL) strategy has been developed to form bulk heterojunction (BHJ) structure for processing efficient organic solar cells (OSCs). Herein, LbL slot-die coating with twin boiling point solvents (TBPS) strategy was developed to fabricate highly efficient OSCs, which matches with large-scale, high throughput roll-to-roll (R2R) industrialized mass process. The TBPS strategy could produce high-quality thin film without any additive, leading to the optimized vertical phase separation with interpenetrating nanostructures, as well as the enhanced charge transport and extraction. Thus, the power conversion efficiency up to 14.42% was achieved for [(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)-benzo [1,2-b:4,5-b′]dithiophene))-alt-(5,5-(1′,3′-di-2-thienyl-5′,7′-bis(2-ethylhexyl)benzo[1′,2′-c:4′,5′-c′]dithiophene-4,8-dione)]:2,2′-((2Z,2′Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,3″:4″,5″]thieno[2′,3′:4,5]pyrrolo[3,2-g]thieno[2′,3′:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene)) bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (PM6:Y6) OSCs fabricated via sequentially LbL slot-die coating using the TBPS strategy under ambient condition. The research provides a potential route for industrialized production of high-efficiency and large-area OSC devices.
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- 2021
178. Infinite Coordination Polymer Nanoparticles Used for Fluorescence Turn-On Sensing of Ascorbic Acid
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Qian Tang, Zhe Sun, Shi Zhe Du, Nian Bing Li, Jiao Zhou, Lei Wang, Min Qing, and Hong Qun Luo
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Turn (biochemistry) ,chemistry.chemical_compound ,chemistry ,Coordination polymer ,Nanoparticle ,General Materials Science ,Ascorbic acid ,Photochemistry ,Fluorescence - Published
- 2021
179. Reduced fecal short-chain fatty acids levels and the relationship with gut microbiota in IgA nephropathy
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Qun Luo, Kaiyue Wang, Binbin Xu, Ke-Dan Cai, and Lingxiong Chai
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,030232 urology & nephrology ,Urine ,Gut microbiota ,Gut flora ,urologic and male genital diseases ,Caproic Acid ,Nephropathy ,Isobutyric acid ,Butyric acid ,Feces ,03 medical and health sciences ,chemistry.chemical_compound ,Short-chain fatty acids ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Eubacterium ,biology ,business.industry ,Research ,Glomerulonephritis, IGA ,IgA nephropathy ,Fatty Acids, Volatile ,biology.organism_classification ,medicine.disease ,Diseases of the genitourinary system. Urology ,Gastrointestinal Microbiome ,030104 developmental biology ,Endocrinology ,chemistry ,Nephrology ,Case-Control Studies ,Dysbiosis ,Female ,RC870-923 ,business ,Biomarkers ,Blood Chemical Analysis - Abstract
Background IgA nephropathy(IgAN)) is the common pathological type of glomerular diseases. The role of gut microbiota in mediating “gut-IgA nephropathy” has not received sufficient attention in the previous studies. The purpose of this study was to investigate the changes of fecal short-chain fatty acids(SCFAs), a metabolite of the intestinal microbiota, in patients with IgAN and its correlation with intestinal flora and clinical indicators, and to further investigate the role of the gut-renal axis in IgAN. Methods There were 29 patients with IgAN and 29 normal control subjects recruited from January 2018 to May 2018. The fresh feces were collected. The fecal SCFAs were measured by gas chromatography/mass spectrometry and gut microbiota was analysed by16S rDNA sequences, followed by estimation of α- and β-diversity. Correlation analysis was performed using the spearman’s correlation test between SCFAs and gut microbiota. Results The levels of acetic acid, propionic acid, butyric acid, isobutyric acid and caproic acid in the IgAN patients were significantly reduced compared with control group(P P = 0.010) and isobutyric acid(r=-0.298, P = 0.022) were negatively correlated with urea acid; butyric acid(r=-0.316, P = 0.016) was negatively correlated with urea nitrogen; caproic acid(r=-0.415,P = 0.025) showed negative correlation with 24-h urine protein level.Exemplified by the results of α-diversity and β-diversity, the intestinal flora of IgAN patients was significantly different from that of the control group. Acetic acid was positively associated with c_Clostridia(r = 0.357, P = 0.008), o_Clostridiales(r = 0.357, P = 0.008) and g_Eubacterium_coprostanoligenes_group(r = 0.283, P = 0.036). Butyric acid was positively associated with g_Alistipes (r = 0.278, P = 0.040). The relative abundance of those were significantly decreased in IgAN group compared to control group. Conclusions The levels of fecal SCFAs in the IgAN patients were reduced, and correlated with clinical parameters and gut microbiota, which may be involved in the pathogenesis of IgAN, and this finding may provide a new therapeutic approach.
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- 2021
180. Real-Time Characterization of the Fine Structure and Dynamics of an Electrical Double Layer at Electrode–Electrolyte Interfaces
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Lanqun Mao, Jilin Tang, Yao Zhao, Zihua Zhu, Yanyan Zhang, Zhigang Ni, Feifei Jia, Qun Luo, and Fuyi Wang
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Materials science ,02 engineering and technology ,Electrolyte ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Characterization (materials science) ,Secondary ion mass spectrometry ,Adsorption ,Chemical engineering ,Chemisorption ,Phase (matter) ,Electrode ,General Materials Science ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
The chemisorption of an electrolyte species on electrode surfaces is ubiquitous and affects the dynamics and mechanism of various electrochemical reactions. Understanding of the chemical structure and property of the resulting electrical double layer is vital but limited. Herein, we operando probed the electrochemical interface between a gold electrode surface and a common electrolyte, phosphate buffer, using our newly developed in situ liquid secondary ion mass spectrometry. We surprisingly found that, on the positively charged gold electrode surface, sodium cations were anchored in the Stern layer in a partially dehydrated form by a formation of compact ion pairs with the accumulated phosphate anions. The resulting strong adsorption phase was further revealed to retard the electro-oxidation reaction of ascorbate. This finding addressed one major gap in the fundamental science of electrode-electrolyte interfaces, namely, where and how cations reside in the double layer to impose effects on electrochemical reactions, providing insights into the engineering of better electrochemical systems.
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- 2021
181. Universal and Programmable Rolling Circle Amplification-CRISPR/Cas12a-Mediated Immobilization-Free Electrochemical Biosensor
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Hong Qun Luo, Min Qing, Yi Fan, Zhe Sun, Nian Bing Li, and Sheng Liang Chen
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Modularity (networks) ,010401 analytical chemistry ,Biosensing Techniques ,DNA ,Computational biology ,010402 general chemistry ,Deoxyribonuclease activity ,01 natural sciences ,Signal ,Small molecule ,0104 chemical sciences ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Rolling circle replication ,Nucleic Acids ,Nucleic acid ,CRISPR ,Clustered Regularly Interspaced Short Palindromic Repeats ,CRISPR-Cas Systems - Abstract
The development of a sensing platform with high sensitivity and specificity, especially programmability and universal applicability, for the detection of clinically relevant molecules is highly valuable for disease monitoring and confirmation but remains a challenge. Here, for the first time, we introduce the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system into an immobilization-free electrochemical biosensing platform for sensitively and specifically detecting the disease-related nucleic acids and small molecules. In this strategy, a modular rolling circle amplification (RCA) is designed to transform and amplify the target recognition event into the universal trigger DNA strand that is used as the trigger to activate the deoxyribonuclease activity of CRISPR/Cas12a for further signal amplification. The cleavage of the target-activated blocker probe allows the methylene blue-labeled reporter probes to be captured by the reduced graphene oxide-modified electrode, leading to an obviously increased electrochemical signal. We only need to simply tune the sequence for target recognition in RCA components, and this strategy can be flexibly applied to the highly sensitive and specific detection of microRNAs, Parvovirus B19 DNA, and adenosine-5'-triphosphate and the calculated limit of detection is 0.83 aM, 0.52 aM, and 0.46 pM, respectively. In addition, we construct DNA logic circuits (YES, NOT, OR, AND) of DNA inputs to experimentally demonstrate the modularity and programmability of the stimuli-responsive RCA-CRISPR/Cas12a system. This work broadens the application of the CRISPR/Cas12a system to the immobilization-free electrochemical biosensing platform and provides a new thinking for developing a robust tool for clinical diagnosis.
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- 2021
182. One-step synthesis of aldehyde-functionalized dual-emissive carbon dots for ratiometric fluorescence detection of bisulfite in food samples
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Cui Cui Deng, Zi Yi Xu, Zhe Sun, Jia Hao Xie, Hong Qun Luo, and Nian Bing Li
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Aldehydes ,Humans ,Sulfites ,General Medicine ,Fluorescence ,Carbon ,Food Science ,Analytical Chemistry - Abstract
Bisulfite (HSO
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- 2022
183. Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
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Jonathan Barratt, Richard Lafayette, Jens Kristensen, Andrew Stone, Daniel Cattran, Jürgen Floege, Vladimir Tesar, Hernán Trimarchi, Hong Zhang, Necmi Eren, Alexander Paliege, Brad H. Rovin, Guillermo Fragale, Alejandra Karl, Patricia Losisolo, Ivan Gonzalez Hoyos, Mauro Guillermo Lampo, Matias Monkowski, Jorge De La Fuente, Magdalena Alvarez, Daniela Stoppa, Carlos Chiurchiu, Pablo Antonio Novoa, Marcelo Orias, Maria Belen Barron, Ana Giotto, Mariano Arriola, Evelin Cassini, Rafael Maldonado, Maria Paula Dionisi, Jessica Ryan, Nigel Toussaint, Grant Luxton, Chen Au Peh, Vicki Levidiotis, Ross Francis, Richard Phoon, Elena Fedosiuk, Dmitry Toropilov, Ruslan Yakubtsevich, Elena Mikhailova, Christophe Bovy, Nathalie Demoulin, Jean-Michel Hougardy, Bart Maes, Marijn Speeckaert, Louis-Philippe Laurin, Sean Barbour, Melanie Masse, Michelle Hladunewich, Heather Reich, Serge Cournoyer, Karthik Tennankore, Jicheng Lv, Zhangsuo Liu, Caili Wang, Shaomei Li, Qun Luo, Zhaohui Ni, Tiekun Yan, Ping Fu, Hong Cheng, Bicheng Liu, Wanhong Lu, Jianqin Wang, Qinkai Chen, DeGuang Wang, Zuying Xiong, Menghua Chen, Yan Xu, Jiali Wei, Pearl Pai, Lianhua Chen, Jitka Rehorova, Dita Maixnerova, Roman Safranek, Ivan Rychlik, Miroslav Hruby, Satu Makela, Kati Vaaraniemi, Fernanda Ortiz, Eric Alamartine, Maite Daroux, Claire Cartery, Francois Vrtovsnik, Jean-Emmanuel Serre, Eleni Stamellou, Volker Vielhauer, Christian Hugo, Klemens Budde, Britta Otte, Martin Nitschke, Evangelia Ntounousi, Ioannis Boletis, Aikaterini Papagianni, Dimitrios Goumenos, Konstantinos Stylianou, Synodi Zermpala, Ciro Esposito, Mario Gennaro Cozzolino, Sara Maria Viganò, Loreto Gesualdo, Michal Nowicki, Tomasz Stompor, Ilona Kurnatowska, Sung Gyun Kim, Yong-Lim Kim, Ki-Ryang Na, Dong Ki Kim, Su-Hyun Kim, Luis Quintana Porras, Eva Rodriguez Garcia, Irene Agraz Pamplona, Alfons Segarra, Marian Goicoechea, Bengt Fellstrom, Sigrid Lundberg, Peter Hemmingsson, Gregor Guron, Anna Sandell, Cheng-Hsu Chen, Bulent Tokgoz, Soner Duman, Mehmet Riza Altiparmak, Metin Ergul, Peter Maxwell, Patrick Mark, Kieran McCafferty, Arif Khwaja, Chee Kay Cheung, Matthew Hall, Albert Power, Durga Kanigicherla, Richard Baker, Jim Moriarty, Amr Mohamed, Joseph Aiello, Pietro Canetta, Isabelle Ayoub, Derrick Robinson, Surabhi Thakar, Amy Mottl, Isaac Sachmechi, Bernard Fischbach, Harmeet Singh, Jeffrey Mulhern, Fahmeedah Kamal, Douglas Linfert, Dana Rizk, Shikha Wadhwani, Menaka Sarav, Kirk Campbell, Gaia Coppock, Randy Luciano, John Sedor, Rupali Avasare, Wai Lang Lau, Zermpala, Synodi, Esposito, Ciro, Cozzolino, Mario Gennaro, Viganò, Sara Maria, Gesualdo, Loreto, Nowicki, Michal, Stompor, Tomasz, Kurnatowska, Ilona, Kim, Sung Gyun, Kim, Yong-Lim, Na, Ki-Ryang, Kim, Dong Ki, Kim, Su-Hyun, Porras, Luis Quintana, Garcia, Eva Rodriguez, Pamplona, Irene Agraz, Segarra, Alfons, Goicoechea, Marian, Fellstrom, Bengt, Lundberg, Sigrid, Hemmingsson, Peter, Guron, Gregor, Sandell, Anna, Chen, Cheng-Hsu, Tokgoz, Bulent, Duman, Soner, Altiparmak, Mehmet Riza, Ergul, Metin, Maxwell, Peter, Mark, Patrick, Fragale, Guillermo, McCafferty, Kieran, Khwaja, Arif, Cheung, Chee Kay, Hall, Matthew, Power, Albert, Kanigicherla, Durga, Baker, Richard, Moriarty, Jim, Mohamed, Amr, Aiello, Joseph, Karl, Alejandra, Canetta, Pietro, Ayoub, Isabelle, Robinson, Derrick, Thakar, Surabhi, Mottl, Amy, Sachmechi, Isaac, Fischbach, Bernard, Singh, Harmeet, Mulhern, Jeffrey, Kamal, Fahmeedah, Losisolo, Patricia, Linfert, Douglas, Rizk, Dana, Wadhwani, Shikha, Sarav, Menaka, Campbell, Kirk, Coppock, Gaia, Luciano, Randy, Sedor, John, Avasare, Rupali, Lau, Wai Lang, Trimarchi, Hernán, Hoyos, Ivan Gonzalez, Lampo, Mauro Guillermo, Monkowski, Matias, De La Fuente, Jorge, Alvarez, Magdalena, Stoppa, Daniela, Chiurchiu, Carlos, Novoa, Pablo Antonio, Orias, Marcelo, Barron, Maria Belen, Giotto, Ana, Arriola, Mariano, Cassini, Evelin, Maldonado, Rafael, Dionisi, Maria Paula, Ryan, Jessica, Toussaint, Nigel, Luxton, Grant, Peh, Chen Au, Levidiotis, Vicki, Francis, Ross, Phoon, Richard, Fedosiuk, Elena, Toropilov, Dmitry, Yakubtsevich, Ruslan, Mikhailova, Elena, Bovy, Christophe, Demoulin, Nathalie, Hougardy, Jean-Michel, Maes, Bart, Speeckaert, Marijn, Laurin, Louis-Philippe, Barbour, Sean, Masse, Melanie, Hladunewich, Michelle, Reich, Heather, Cournoyer, Serge, Tennankore, Karthik, Lv, Jicheng, Liu, Zhangsuo, Wang, Caili, Li, Shaomei, Luo, Qun, Ni, Zhaohui, Yan, Tiekun, Fu, Ping, Cheng, Hong, Liu, Bicheng, Lu, Wanhong, Wang, Jianqin, Chen, Qinkai, Wang, DeGuang, Xiong, Zuying, Chen, Menghua, Xu, Yan, Wei, Jiali, Pai, Pearl, Chen, Lianhua, Rehorova, Jitka, Maixnerova, Dita, Safranek, Roman, Rychlik, Ivan, Hruby, Miroslav, Makela, Satu, Vaaraniemi, Kati, Ortiz, Fernanda, Alamartine, Eric, Daroux, Maite, Cartery, Claire, Vrtovsnik, Francois, Serre, Jean-Emmanuel, Stamellou, Eleni, Vielhauer, Volker, Hugo, Christian, Budde, Klemens, Otte, Britta, Nitschke, Martin, Ntounousi, Evangelia, Boletis, Ioannis, Papagianni, Aikaterini, Goumenos, Dimitrios, Stylianou, Konstantinos, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, and UCL - (SLuc) Service de néphrologie
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gut-associated lymphoid tissue ,glucocorticoids ,Nephrology ,glomerular disease ,IgA nephropathy - Abstract
Kidney international 103(2), 391-402 (2022). doi:10.1016/j.kint.2022.09.017, Published by Elsevier, New York, NY
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- 2022
184. Clinical characteristics of sitosterolemic children with xanthomas as the first manifestation
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Jun, Zhang, Qiu-Li, Chen, Song, Guo, Yan-Hong, Li, Chuan, Li, Ru-Jiang, Zheng, Xue-Qun, Luo, and Hua-Mei, Ma
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Male ,Endocrinology, Diabetes and Metabolism ,Hypercholesterolemia ,Biochemistry (medical) ,Clinical Biochemistry ,Phytosterols ,Cholesterol, LDL ,Lipid Metabolism, Inborn Errors ,Hyperlipoproteinemia Type II ,Intestinal Diseases ,Cholesterol ,Endocrinology ,Xanthomatosis ,Humans ,Child - Abstract
Background: Sitosterolemia (STSL) is an extremely rare genetic disease. Xanthomas as the first symptom are frequently misinterpreted as familial hypercholesterolemia (FH) in children. Inappropriate treatment may deteriorate the condition of STSL. Objectives: To present the clinical and laboratory characteristics of xanthomatous children diagnosed with sitosterolemia in comparison with childhood FH with xanthomas. Methods: We summarized and compared the clinical characteristics of STSL and FH patients with xanthomas as the first manifestations and investigated the different indicators between the STSL and FH groups, as well as their diagnostic values for STSL. Results: Two tertiary pediatric endocrinology departments contributed ten STSL cases. Five of the STSL patients (50%) experienced mild anemia, whereas two (20%) had vascular complications. The xanthomas of the STSL group displayed morphologies comparable to those of the FH group. There were ten cases of homozygous FH (HoFH) with xanthomas as the predominant symptom of the control group who had no anemia. The serum cholesterol (Chol) levels of the STSL and FH groups were 12.57 (9.55 ~ 14.62) mmol/L and 17.45 (16.04 ~ 21.47) mmol/L, respectively (p value 0.002). The serum low-density lipoprotein cholesterol (LDL-c) levels of the STSL and FH groups were 9.26 ± 2.71 mmol/L and 14.58 ± 4.08 mmol/L, respectively (p value 0.003). Meanwhile, the mean platelet volume (MPV) levels of the STSL and FH groups were 11.00 (9.79 ~ 12.53) fl. and 8.95 (8.88 ~ 12.28) fl., respectively (p value 0.009). The anemia proportions of the STSL and FH groups were 50% and 0%, respectively (p value 0.033). The AUC values of Chol, LDL-c, MPV, hemoglobin (Hb) for the diagnosis of STSL were 0.910, 0.886, 0.869, 0.879, respectively. Chol ≤ 15.41 mmol/L, LDL-c ≤ 13.22 mmol/L, MPV ≥ 9.05 fl., or Hb≤120 g/L were the best thresholds for diagnosing STSL with childhood xanthomas. Conclusion The xanthoma morphology of STSL patients resembles that of FH patients. Xanthomas as the initial symptom of a child with Chol ≤ 15.41 mmol/L, LDL-c≤13.22 mmol/L, MPV ≥ 9.05 fl., or Hb≤120 g/L, he was most likely to have STSL.
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- 2022
185. In situ performance and stability tests of flexible polymer:non-fullerene solar cells at 35 km stratospheric environment
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Qun Luo, Zihan Xu, Guoning Xu, Yunfei Han, Yu Tang, Jian Qin, and Chang-Qi Ma
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- 2022
186. Heteroatoms Adjusting Amorphous FeMn-Based Nanosheets via a Facile Electrodeposition Method for Full Water Splitting
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Hong Qun Luo, Juan Luo, Li Li Wu, Nian Bing Li, Li Shen, Qing Zhang, Hong Chuan Fu, and Xiao Hui Chen
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Materials science ,Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Heteroatom ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Amorphous solid ,Chemical engineering ,Environmental Chemistry ,Water splitting ,Metal catalyst ,0210 nano-technology - Abstract
There still exists a resplendent prospect of developing a robust and stable non-noble metal catalyst for overall water splitting. Herein, we designed highly efficient amorphous FeMn-based electroca...
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- 2021
187. An Efficiency of 16.46% and a T80 Lifetime of Over 4000 h for the PM6:Y6 Inverted Organic Solar Cells Enabled by Surface Acid Treatment of the Zinc Oxide Electron Transporting Layer
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Zhiyun Li, Xingze Chen, Wei Pan, Fangsen Li, Rong Huang, Bowen Liu, Yunfei Han, Chang-Qi Ma, Jianqi Zhang, Qun Luo, Huilong Dong, and Zhixiang Wei
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Materials science ,Organic solar cell ,Energy conversion efficiency ,chemistry.chemical_element ,Heterojunction ,02 engineering and technology ,Zinc ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Acceptor ,0104 chemical sciences ,Active layer ,law.invention ,Chemical engineering ,chemistry ,law ,Solar cell ,Photocatalysis ,General Materials Science ,0210 nano-technology - Abstract
For the inverted organic solar cells (OSCs), the interface contacts between the ZnO electron transporting layer and the organic active layer play an important role in the device performance and stability. Since the solution-processed ZnO surface always contains some base or zinc salt contaminants, we explored how the surface pH conditions influence the performance and stability of the nonfullerene acceptor (NFA) cells. A tight relationship between the surface pH condition and the device performance and stability was established. Specifically, device performance and stability were improved by treating the ZnO films with acid solutions but worsened after base treatment. The large number of hydroxyl groups on the surface of the solution-processed ZnO films was proved to be the main reason for the surface pH condition-related performance, which caused oxygen-deficient defects and unfavorable vertical phase separation in the blend films, hindered the photogenerated charge transfer and collection, and consequently resulted in low short-circuit current density and power conversion efficiency (PCE). The surface -OH groups also boosted the photocatalytic activity and led to fast degradation of the nonfullerene acceptor. Removal of the surface -OH groups can alleviate such problems. Different acid solutions, ZrAcac, 2-phenylethylmercaptan (PET), and glutamic acid (GC), were used to treat the ZnO films, and PET treatment was the most effective treatment for performance improvement. An efficiency of 16.46% was achieved for the PM6:Y6 cells and the long-term stability under continuous illumination conditions was significantly improved with a T80 lifetime of over 4000 h (4410 h), showing the excellent long-term stability of this heterojunction solar cell. Our understanding of the surface pH condition-related device performance and stability would guide the development of a feasible method for solving the interface problems in OSCs. We also provide a practical strategy to modify ZnO with acid solutions for high-performance and stable NFA OSCs.
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- 2021
188. Influence of the Location of Electron-Donating 3,4-Ethylenedioxythiophene (EDOT) Moiety in the A–π–D–π–A Type Conjugated Molecules on the Optoelectronic Properties and Photovoltaic Performances
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Chang-Qi Ma, Hai-Bo Yang, Lilei Wang, Qun Luo, Wei Gao, Hongwei Tan, Ying Zhang, Yi Lin, and Guan Xiang
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Materials science ,Absorption spectroscopy ,Organic solar cell ,Band gap ,a–π–d–π–a small molecules ,02 engineering and technology ,Conjugated system ,010402 general chemistry ,01 natural sciences ,Moiety ,Molecule ,organic semiconductors ,QD1-999 ,chemistry.chemical_classification ,benzo[1,2-b:4,5-b′]dithiophene derivatives ,3,4-ethylenedioxythiophene ,organic solar cells ,General Medicine ,Electron acceptor ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Organic semiconductor ,Crystallography ,Chemistry ,chemistry ,0210 nano-technology - Abstract
A–π–D–π–A type conjugated small molecules play an indispensable role in organic photovoltaics. Understanding the relationship between the molecular structure and performance is a fundamental question for the further rational design of high-performance organic materials. To red-shift the absorption spectrum of benzo[1,2-b:4,5-b']dithiophene (BDT) based A–π–D–π–A type compounds, an electron-donating 3,4-ethylenedioxythiophene (EDOT) moiety was introduced into the π-conjugation bridge unit. Two new compounds with EDOT next to the central BDT core (COOP-2HT-EDOT-BDT) or next to the terminal electron acceptor unit (COOP-EDOT-2HT-BDT) were synthesized and characterized. The compound COOP-2HT-EDOT-BDT showed higher molar extinction coefficient (εabs max = 1.06 × 105 L mol−1 cm−1), lower optical band gap (E g = 1.56 eV) and high HOMO energy level (E HOMO = −5.08 eV) than COOP-EDOT-2HT-BDT (εabs max = 0.96 × 105 L mol−1 cm−1, E g = 1.71 eV, E HOMO = −5.26 eV), which is attributed to the intensive interaction between the EDOT unit and the HOMO orbital, as confirmed by the theoretical calculation results. However, the higher power conversion efficiency of 3.58% was achieved for the COOP-EDOT-2HT-BDT:PC61BM-based solar cells, demonstrating that the electron-donating EDOT unit adjacent to the electron-withdrawing end-capped group (COOP) is a better way to achieve high-performance photovoltaic materials.
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- 2021
189. Suppression of ion migration through cross-linked PDMS doping to enhance the operational stability of perovskite solar cells
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Fangsen Li, Changzeng Ding, X.F. Sun, Shuxuan Guo, Guanghui Han, Chang-Qi Ma, Yuanjie Li, Jiachen Kang, Qun Luo, Irfan Ismail, and Rong Huang
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Materials science ,Polydimethylsiloxane ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Doping ,02 engineering and technology ,021001 nanoscience & nanotechnology ,law.invention ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,law ,Phase (matter) ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,Crystallization ,0210 nano-technology ,Short circuit ,Layer (electronics) ,Curing (chemistry) ,Perovskite (structure) - Abstract
Although perovskite solar cells have achieved great development in the device performance, the device stability is still a crucial issue hinder the further development. The ion migration is a main reason for the poor stability of the perovskite solar cells. Here, we use a cross-linking material, polydimethylsiloxane (PDMS) to dope the perovskite layer to improve the operational stability. We systematically studied the effect of curing agent content in PDMS on the device performance and stability. The characterization of perovskite film indicates that PDMS primarily doped in the perovskite layer and as well as enriched at the surface of perovskite film. Doping of PDMS promoted the crystallization of perovskite phase, leading to increase of short circuit density (JSC) and fill factor (FF) of the solar cells. In addition, PDMS doping improved the operational stability of device due to the suppressing the migration of iodide ions during aging. Moreover, the higher content of curing agents used in PDMS, the better stability of the devices. This work indicates PDMS doping the perovskite layer with a suitable content of curing agent can produce a better operational stability of the perovskite solar cells.
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- 2021
190. Guidelines for Diagnosis and Treatment of Atopic Dermatitis in China (2020)#
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Atopic Dermatitis Working Group, Immunology Group, Chinese Society of Dermatology, Xu Yao, Zhi-Qiang Song, Wei Li, Yun-Sheng Liang, Yan Zhao, Hua Cao, Tao Chen, Xue Chen, Ai-Ping Feng, Song-Mei Geng, Heng Gu, Shu-Ping Guo, Yan-Ling He, Ye-Hong Kuang, Chun-Ying Li, Xiao-Hong Li, Zheng-Xiao Li, Jun-Qin Liang, Hong-Ye Liu, Ling-Ling Liu, Yu-Mei Liu, Zhi Liu, Hai Long, Qian-Jin Lu, Yan Lu, Xiao-Qun Luo, Xiao-Yan Lv, Lin Ma, Zhu Shen, Xin Shi, Zhong-Xiang Shi, Xiang-Yang Su, Qing Sun, Jian-Ping Tang, Ao-Xue Wang, Hui-Ping Wang, Jian-Qin Wang, Ming-Yue Wang, Zai-Xing Wang, Yu-Min Xia, Ting Xiao, Zhi-Qiang Xie, Huan Xing, Ying Xiong, Zi-Gang Xu, Bin Yang, Zhi-Rong Yao, Jian-Bin Yu, Nan Yu, Kang Zeng, Jian-Zhong Zhang, Jun-Ling Zhang, Hua Zhao, Zuo-Tao Zhao, Wei Zhu, Ying-Hua Zhu, and Ying Zou
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body regions ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,RL1-803 ,Medicine ,Atopic dermatitis ,Dermatology ,China ,business ,medicine.disease - Abstract
Atopic dermatitis (AD) is a common disease clinically characterized by chronic recurrent eczematous lesions, dry skin, and pruritus. AD can negatively impact patients’ quality of life. The prevalence of AD in China has been increasing during the past few decades. Based on the most recent advances in the treatment of AD, we updated the 2014 version of the Guidelines for Diagnosis and Treatment of Atopic Dermatitis in China regarding the definition, epidemiology, pathogenesis, clinical classification, diagnosis, prevention, and treatment of AD.
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- 2021
191. Advances on the Mechanism of Reservoir Forming and Gas Accumulation of the Longmaxi Formation Shale in Sichuan Basin, China
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Guozhen Wang, Yan Song, Xianglu Tang, Zhenxue Jiang, Zhuo Li, Qun Luo, and Xingmeng Wang
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business.industry ,Shale gas ,020209 energy ,General Chemical Engineering ,Sichuan basin ,Geochemistry ,Energy Engineering and Power Technology ,02 engineering and technology ,Fuel Technology ,020401 chemical engineering ,Natural gas ,0202 electrical engineering, electronic engineering, information engineering ,0204 chemical engineering ,China ,business ,Oil shale ,Geology ,Mechanism (sociology) - Abstract
Shale gas has become one of the most important natural gas resources. The Sichuan Basin in China is one of the main shale gas production areas and has entered large-scale commercial development. Th...
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- 2021
192. Understanding grain refining and anti Si-poisoning effect in Al-10Si/Al-5Nb-B system
- Author
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Bin Liu, Qian Li, Qun Luo, Ying Jiang, Yang Li, and Bin Hu
- Subjects
Materials science ,Polymers and Plastics ,Mechanical Engineering ,Metallurgy ,Metals and Alloys ,Nucleation ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Casting ,0104 chemical sciences ,Mechanics of Materials ,Transmission electron microscopy ,Materials Chemistry ,Ceramics and Composites ,Ingot ,0210 nano-technology ,Refining (metallurgy) - Abstract
Grain refinement is critical for fabricating high-quality Al-Si casting components in the application of automobile and aerospace industries, while the well-known Si-poisoning effect makes it difficult. Nb-based refiners offer an effective method to refine Al-Si casting alloys, but their anti Si-poisoning capability is far from being understood. In this work, the grain refining mechanism and the anti Si-poisoning effect in the Al-10Si/Al-5Nb-B system were systematically investigated by combining transmission electron microscope, first-principles calculations, and thermodynamic calculations. It is revealed that NbB2 provides the main nucleation site in the Al-10Si ingot inoculated by 0.1 wt.%Nb Al-5Nb-B refiner. The exposed Nb atoms on the (0 0 0 1) NbB2 and (1 -1 0 0) NbB2 surface can be substituted by Al to form (Al,Nb)B2 intermedia layers. In addition, a layer of NbAl3-like compound (NbAl3’) can cover the surface of NbB2 with the orientation relation of (1 -1 0 0)[1 1–2 0] NbB2//(1 1 0)[1 1 0] NbAl3’. Both of the (Al,Nb)B2 and NbAl3’ intermedia layers contribute to enhancing the nucleation potency of NbB2 particles. These discoveries provide fundamental insight to the grain refining mechanism of the Nb-B based refiners for Al-Si casting alloys and are expected to guide the future development of stronger refiners for Al-Si casting alloys.
- Published
- 2021
193. Crystal facet engineering of polar single crystal BiOCl with improved piezo-photocatalytic activity
- Author
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Zi Qing Li, Xiao Hui Chen, Ting Li, Bing Jie Wang, Nian Bing Li, and Hong Qun Luo
- Subjects
General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
194. Enhanced oxidation resistance in Mg-Y-Zn-Ho alloys via introducing dense low-oxygen-diffusion Ho2O3 oxide film
- Author
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Mingyu Fan, Ye Cui, Zhongwu Zhang, Liyuan Liu, Qian Li, and Qun Luo
- Subjects
General Chemical Engineering ,General Materials Science ,General Chemistry - Published
- 2023
195. Kill two birds with one stone: Ratiometric sensing of phosphate via a single-component probe with fluorescence-scattering dual-signal response behavior
- Author
-
Hang Yan, Zhe Sun, Min Qing, Yu Ling, Wei Wei Liu, Nian Bing Li, and Hong Qun Luo
- Subjects
Environmental Chemistry ,Biochemistry ,Spectroscopy ,Analytical Chemistry - Published
- 2023
196. In-situ and ex-situ investigation of deformation behaviors of a dual-phase Mg−Ni−Y alloy
- Author
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Cheng Liu, Xiaohua Yang, Jianchao Peng, Bin Liu, Qun Luo, Qian Li, and Kuo-Chih Chou
- Subjects
Mechanics of Materials ,Mechanical Engineering ,Metals and Alloys ,General Materials Science ,Condensed Matter Physics - Published
- 2023
197. DNA methylation of ITGB2 contributes to allopurinol hypersensitivity
- Author
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Yu Liu, Chuang-Wei Wang, Chun-Bing Chen, Kuang-Hui Yu, Yeong-Jian Wu, Siew-Eng Choon, Wan-Chun Chang, Fanping Yang, Xiao-Qun Luo, Wen-Hung Chung, Ming Zhao, and Qian-Jin Lu
- Subjects
Immunology ,Immunology and Allergy - Published
- 2023
198. Mercury ion-engineering Au plasmonics on MoS2 layers for absorption-shifted optical sensors
- Author
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Bang Lin Li, Jun Jiang Luo, Hong Qun Luo, Xiao Juan Du, Nian Bing Li, and Ling Yun Qin
- Subjects
Nanostructure ,Materials science ,business.industry ,General Chemical Engineering ,General Engineering ,chemistry.chemical_element ,Heterojunction ,Surface engineering ,Conjugated system ,Analytical Chemistry ,Mercury (element) ,Ion ,chemistry ,Optoelectronics ,Absorption (electromagnetic radiation) ,business ,Plasmon - Abstract
Semiconducting MoS2 layers offer the electrons, reducing conjugated Au(I) to Au atoms, and sebsequently serve as desirable substrates for supporting the interfacial growths of gold nanostructures. Au-covering MoS2 heterostructures perform morphology-varied optical characteristics, and the surface engineering of MoS2 involved by Hg2+ ions results in the differential growths of nanostructures and morphological diversities. Naked-eye colorimetric responses to mercury ions, with a low limit of detection of 1.27 nM, are achieved based on the in situ grown heterostructures.
- Published
- 2021
199. Synergetic effects of electrochemical oxidation of Spiro-OMeTAD and Li+ ion migration for improving the performance of n–i–p type perovskite solar cells
- Author
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Liangping Zhang, Changzeng Ding, Dongyu Zhang, Fangsen Li, Chang-Qi Ma, Ronald Österbacka, Rong Huang, Qun Luo, Jian Lin, and Christian Ahläng
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Energy conversion efficiency ,02 engineering and technology ,General Chemistry ,Conductivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Cathode ,0104 chemical sciences ,law.invention ,Anode ,Secondary ion mass spectrometry ,Chemical engineering ,law ,Solar cell ,General Materials Science ,0210 nano-technology ,Perovskite (structure) - Abstract
n–i–p Type perovskite solar cells generally require air oxidation of the Spiro-OMeTAD layer to achieve high power conversion efficiency (PCE). However, the detailed oxidation mechanism is still not fully understood. In this paper, oxidation of Spiro-OMeTAD was demonstrated via a non-contact electrochemical route using UV-Vis absorption, laser beam induced current (LBIC) imaging and secondary ion mass spectrometry (SIMS) profiling of the Spiro-OMeTAD films. At the cathode, oxygen is reduced to form OH− with the help of H2O, while the anodic reaction is the oxidation of Spiro-OMeTAD to form Spiro-OMeTAD+. Diffusion of Li+ towards the surface of the Ag electrode completes the electrochemical cycle and increases the conductivity of the hole-transporting layer. SIMS analyses of the completed devices demonstrate that the oxidation of Spiro-OMeTAD also leads to migration of Li+ through the perovskite layer into SnO2, which supposedly leads to an increase of the built-in voltage. We verify these results by incorporation of the experimentally measured Li+ concentration into a numerical drift-diffusion simulation, to replicate solar cell J–V-curves. This work provides a new insight into the oxidation of Spiro-OMeTAD in perovskite solar cells, and demonstrates that Li+ migration is involved in the oxidation of Spiro-OMeTAD.
- Published
- 2021
200. Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA
- Author
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Nan Li, Fei Gao, Pu Dong, Yu Lin, Fuyi Wang, Luyu Qi, Zhaoying Wang, Yao Zhao, Suyan Liu, Qun Luo, Wei Zheng, Feifei Jia, Ling Chen, Xiaohong Fang, Yanyan Zhang, and Kui Wu
- Subjects
Cisplatin ,0303 health sciences ,Chemistry ,DNA damage ,Cell ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,law.invention ,Cell biology ,03 medical and health sciences ,genomic DNA ,chemistry.chemical_compound ,medicine.anatomical_structure ,Confocal microscopy ,law ,Transcription (biology) ,medicine ,Transcription factor ,DNA ,030304 developmental biology ,medicine.drug - Abstract
Cisplatin is an extremely successful anticancer drug, and is commonly thought to target DNA. However, the way in which cisplatin-induced DNA lesions regulate interactions between transcription factors/cofactors and genomic DNA remains unclear. Herein, we developed a dual-modal microscopy imaging strategy to investigate, in situ, the formation of ternary binding complexes of the transcription cofactor HMGB1 and transcription factor Smad3 with cisplatin crosslinked DNA in single cells. We utilized confocal microscopy imaging to map EYFP-fused HMGB1 and fluorescent dye-stained DNA in single cells, followed by the visualization of cisplatin using high spatial resolution (200–350 nm) time of flight secondary ion mass spectrometry (ToF-SIMS) imaging of the same cells. The superposition of the fluorescence and the mass spectrometry (MS) signals indicate the formation of HMGB1-Pt-DNA ternary complexes in the cells. More significantly, for the first time, similar integrated imaging revealed that the cisplatin lesions at Smad-binding elements, for example GGC(GC)/(CG) and AGAC, disrupted the interactions of Smad3 with DNA, which was evidenced by the remarkable reduction in the expression of Smad-specific luciferase reporters subjected to cisplatin treatment. This finding suggests that Smad3 and its related signalling pathway are most likely involved in the intracellular response to cisplatin induced DNA damage., A dual-modal microscopy imaging strategy was developed to investigate in situ the interactions between transcription (co)factors with cisplatin damaged DNA in single cells, showing that cisplatin lesions disrupted the interactions of Smad3 with DNA.
- Published
- 2021
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