Search

The aim Assessment of safety, diagnostic, and prognostic value of a stress echocardiography protocol based on rapid pacing in patients with implanted permanent pacemakers and concomitant handgrip dynamometer method. There are no data in the literature on this type of modification of the stress test. Methods Rapid pacing stress echo tests with further handgrip were performed in 54 patients (33 females, aged 49-88, mean 72 +/- 8 years), using previously implanted permanent pacemakers. Left ventricular segmental contractility was assessed at rest, during 3 minutes pacing at the rate of 100/minutes, over 5 minutes at 85% of maximal age-predicted heart rate and then further at peak stage per 1 minute with the addition of a handgrip (compression of the dynamometer with a force equal to half the maximum strength of the patient measured before the test). The test was performed using only VVI pacing mode in 16 patients in whom atrial pacing was not possible. In the remaining 38 patients AAI/DDD pacing mode was initially used. Results No severe adverse effects were observed. Significant increase in heart rate comparing to baseline was achieved [74/minutes vs. 127/minutes (P < 00001)]. Wall motion score index increased significantly (from 1.07 vs. 1.15, p Conclusions The sensitivity and specificity of the stress test using the pacemaker and the handgrip method for all patients proved to be lower than the values obtained in other stress tests. However, the use of the handgrip method during stimulation caused an increase in mean systolic and diastolic blood pressure. Such an extension makes the pacing stress echo test more physiological. Moreover the stress test using pacemaker and handgrip method proved to be safe and well-tolerated by patients. The prognostic value of the negative result of the study research using stimulation from the patient"s pacemaker and the handgrip method was high in the 6 month follow-up

The following is presented in the study - the objective factors that determine the necessity to develop non-traditional renewable energy sources and the prerequisites for their development in Ukraine, the energy potential of renewable energy sources. Technologies for the use of geo-information modeling aimed at using the cartographic information base to solve problems of planning, making managerial decisions and developing the energy industry are proposed. Practical implementation of the proposed approach provides for the development of a complex of cartographic works for the needs of renewable energy, the creation of maps of various functional and thematic direction (inventory, valuation, recommendation, forecast) that reflect various aspects (resources, objects, conditions, factors, state and perspectives of industry development) and cover various areas of renewable energy (wind power, solar energy, bioenergy, hydropower geothermal energy). The analysis of the development of renewable energy sources and their use is carried out. The tasks of geoinformation modeling for needs of renewable energy sources and their use are determined. The problems of the development of renewable energy sources and their use in Ukraine are determined. The conducted researches can serve as the basis for works on the construction of a decision support system for optimizing the work of the power industry. The present study presents existing approaches to energy saving perspectives and geoinformation analysis of the conditions for the use of alternative energy sources in Ukraine.

Streptococcus mitis is a common pathogen causing infections in oncological patients. However, cases of abscesses caused by Streptococcus mitis in oncological patients have not been reported so far. We report on 5-year-old child with nephroblastoma and pulmonary and hepatic metastases at diagnosis who went into complete remission undergoing chemotherapy and nephrectomy, and who developed new round lesions in liver and lungs under continuous chemotherapy suggestive of new metastases. Biopsy of the lesions revealed abscesses with detection of Streptococcus mitis. The child was successfully treated with antibiotics, finished chemotherapy per protocol and has been in complete remission for 14 months. Infectious lesions involving organs of typical metastatic dissemination can easily be misdiagnosed as metastases, especially in the absence of symptoms. Histologic proof of lesions suspicious of metastases is mandatory if it leads to a change of prognosis and therapy. Streptococcus mitis can be a causative organism of pulmonary and hepatic abscesses in oncological patients.

The activation of distinct branches of the Wnt signaling network is essential for regulating early vertebrate development. Activation of the canonical Wnt/β-catenin pathway stimulates expression of β-catenin-Lef/Tcf regulated Wnt target genes and a regulatory network giving rise to the formation of the Spemann organizer. Non-canonical pathways, by contrast, mainly regulate cell polarization and migration, in particular convergent extension movements of the trunk mesoderm during gastrulation. By transcriptome analyses, we found caveolin1, caveolin3 and cavin1 to be regulated by Lef1 in the involuting mesoderm of Xenopus embryos at gastrula stages. We show that caveolins and caveolin dependent endocytosis are necessary for proper gastrulation, most likely by interfering with Wnt5a/Ror2 signaling. Wnt5a regulates the subcellular localization of receptor complexes, including Ror2 homodimers, Ror2/Fzd7 and Ror2/dsh heterodimers in an endocytosis dependent manner. Live-cell imaging revealed endocytosis of Ror2/caveolin1 complexes. In Xenopus explants, in the presence of Wnt5a, these receptor clusters remain stable exclusively at the basolateral side, suggesting that endocytosis of non-canonical Wnt/receptor complexes preferentially takes place at the apical membrane. In support of this blocking endocytosis with inhibitors prevents the effects of Wnt5a. Thus, target genes of Lef1 interfere with Wnt5a/Ror2 signaling to coordinate gastrulation movements.

Intelligence knowledge-based systems are important part of natural language processing researches. Appropriate formal models simplify developing of such systems and open new ways to improve their quality. This work is devoted to developing of intelligence knowledge-based system using model based on algebra of finite predicates. The model also isbased on lexicographical computer system which consists of trilingual and explanatory dictionaries. Algebra of finite predicates is used as formalization tool.Problems of distinguishing semantic entities is investigated during research. Method of resolving homonymy ambiguities is used to extract separate entities, thus allowing formalization of semantic relationships. In result formal model of intelligence knowledge-based system was developed.It was shown way to extend the model for different languages.

As part of early drug development, preformulation studies are used to comprehensively explore the properties of new drugs. In particular, this includes the biopharmaceutical characterization and evaluation of impacting factors (e.g. excipients, microenvironmental conditions etc.) by permeation studies. To overcome the limitations of current studies, a novel standardized ex vivo procedure using esophageal mucosa as surrogate has been established successfully and applied to preformulation studies for oromucosal delivery of cyclobenzaprine hydrochloride, a tricyclic muscle relaxant with potential for psychopharmacotherapeutic use. By using the standardized ex vivo permeation process, a twofold enhancement of permeability (0.98 ± 0.16 to 1.96 ± 0.10 * 10-5 cm/s) was observed by adjustment and controlling of microenvironmental pH, empowering a targeted and effective development of sublingual formulations. Predictivity and suitability were superior compared to in vitro experiments using artificial biomimetic membranes, revealing a determination coefficient (R2) of 0.995 vs. 0.322 concerning pH-dependent permeability of cyclobenzaprine. In addition, diffusion properties were extensively examined (e.g. influence of mucosal thicknesses, tissue freezing etc.). The alignment of the study design regarding physiologically/clinically relevant conditions resulted in ex vivo data that allowed for the estimation of plasma AUC levels in the extend of reported in vivo ranges.

The article is devoted to the research of the torque-flow pump operating process. Its work is closely connected to the formation and stable functioning of the toroidal vortex. The theoretical bases of the formation of a toroidal vortex and the process of energy transfer in a torque-flow pump are considered in the research (vane and vortex components of the operating process). The fact of the presence of some additional hydraulic losses due to the mismatch of the location of the toroidal vortex center and the impeller blade edges has been established. The urgency of the paper is increasing the efficiency of torque-flow pump by improving its flowing part. The upgrade of the pump consists of the theoretical justification and practical implementation of the reduction of these additional hydraulic losses. In this aspect, the location of the impeller blade edge is aligned with the toroidal vortex center. The research was performed by conducting a numerical investigation. The calculations of a high specific speed torque-flow pump of three different design configurations of the impeller blades were performed. Practically confirmed increasing of the head (by 3.2 m) and efficiency (by 7-8%) of the pump with the second design of the impeller blades.

The paper raises the question of the possibility of reducing the energy loss of the stage of the centrifugal pump on the disk friction, the relative value of which for the stages of low and ultralow speed can be a significant proportion (up to 40%) of all losses. This is seen as one of the effective ways to increase the efficiency of such stages of centrifugal pumps.

Based on the chemotype of canthin-4-one alkaloids with moderate antimicrobial activity, a collection of variously substituted canthin-4-ones and desaza analogs were synthesized. Key steps in the syntheses were regioselective halogenations of (desaza) canthin-4-one, followed by Pd-catalyzed cross-coupling reactions. The in vitro screening for antimicrobial activity revealed that two 5-substituted canthin-4-ones (3-pyridyl, 2-bromophenyl) exhibit significant activity against Streptococcus entericus, coupled with high selectivity and the lack of cytotoxicity against mammalian cells. The intact canthin-4-one ring system was demonstrated to be essential for antibacterial activity.

Benzo[a]pyrene is a polycyclic aromatic hydrocarbon of well proved toxic effect on animal cells and tissues. We used chicken in ovo developmental model to verify its influence on selected parameters of the heart rhythm and on the antioxidative defense in the heart tissue. We determined that the dose of 1 mg/kg weight of eggs of benzo[a]pyrene strongly activates the glutathione-dependent antioxidative system, but it do not significantly affect the heart conducting system of the chicken embryo. We postulate that further study on the benzo[a]pyrene action during embryonic development of birds is recommended.

In this work we consider a method of lexical units' construction based on relation “Interpreted through”. The purpose of this work is to find the semantic relations between lexical items and modification of program system construction hyper chains. The methods of processing are based on the method of finding the n-th linear logic transformation. The main problem in the processing of vocabulary articles - the problem of processing homonyms is considered. As a result of work an algorithm of hyper chains construction for detection semantic relations between the words of electronic lexicographic system is implemented.

The following is presented in the study - the objective factors that determine the necessity to develop non-traditional renewable energy sources and the prerequisites for their development in Ukraine, the energy potential of renewable energy sources. Technologies for the use of geo-information modeling aimed at using the cartographic information base to solve problems of planning, making managerial decisions and developing the energy industry are proposed. Practical implementation of the proposed approach provides for the development of a complex of cartographic works for the needs of renewable energy, the creation of maps of various functional and thematic direction (inventory, valuation, recommendation, forecast) that reflect various aspects (resources, objects, conditions, factors, state and perspectives of industry development) and cover various areas of renewable energy (wind power, solar energy, bioenergy, hydropower geothermal energy). The analysis of the development of renewable energy sources and their use is carried out. The tasks of geoinformation modeling for needs of renewable energy sources and their use are determined. The problems of the development of renewable energy sources and their use in Ukraine are determined. The conducted researches can serve as the basis for works on the construction of a decision support system for optimizing the work of the power industry. The present study presents existing approaches to energy saving perspectives and geoinformation analysis of the conditions for the use of alternative energy sources in Ukraine., Надані об’єктивні фактори, що обумовлюють необхідність розвитку нетрадиційних відновлюваних джерел енергії та передумови для її розвитку в Україні, енергетичний потенціал відновлюваних джерел енергії. Запропоновано технології застосування геоінформаційного моделювання, орієнтовані на використання картографічної інформації для розв’язку завдань з планування, ухвалення управлінських рішень та розвитку енергетичної галузі. Практична реалізація запропонованого підходу перебачає розробку комплексу картографічних творів для потреб відновлюваної енергетики, укладання карт різної функціональної спрямованості (інвентаризаційних, оцінювальних, рекомендаційних, прогнозних), що відображають різні аспекти (ресурси, об’єкти, умови, фактори, стан та перспективи розвитку галузі) та охоплюють різні напрямки відновлюваної енергетики (вітроенергетику, геліоенергетику, біоенергетику, гідроенергетику та геотермальну енергетику).

Analytical formulas are obtained for the thermal state of a bearing with oil–air lubrication; the viscosity class of the lubricant is taken into account. Recommendations are made regarding the structure of the oil-supply channels and the sealing of the frictional module.

The competitiveness of agricultural enterprises on the international market depends directly on the professional and timely implementation of decisions of control. Its function stipulates for a number of actions, work out methods and tools which aimed at conservation the quality of agricultural products in the period of its storage and transportation in accordance with the consumer’s requirements.Construction of control by a recycling pattern is one of the practical ways to increase the effectiveness of control, when an object that is recognized as fit is subject to repeated checks. The major tasks in the construction of a statistical model of measurement control have been analyzed, a typical monitoring system, a sequential control structure, and its characteristics have been submitted. The suggested control significantly reduces the reject rate in the total mass of products.The obtained result of analytical dependencies is convenient for engineering calculations of other types of numerical control.An example of the application of sequential control of broccoli cabbage in its storage with helping with antiseptic preparations is given. The influence of various antiseptics on different varieties of broccoli cabbage is considered. Such a study helps the manufacturer find the best opportunities to improve the competitiveness of its products.

Cisplatin hat sich bei einer Reihe von padiatrischen Malignomen etabliert. Allerdings ist gerade die Ototoxizitat eine fur Kinder gravierende Nebenwirkung. Britische Forscher glauben, ein Rezept dagegen gefunden zu haben.

Parameters of the oocyte enucleation and fusion with somatic cell for producing of cattle cloned cetohybrids were studied. It was established that the electrofusion efficiency depends on strength, duration and set number of electrical pulse. The optimal parameters for Multiporator (Eppendorf, Germany) were determined: two consistent pulses DC electrical field each of 30 V field strength and 15 msec duration followed by the pulse of AC electrical field of 5 V and 10 sec duration. It was found that the first polar body serving as a marker for the chromosome position at «blind» enuclea-tion must not deviate from the chromosome location by more than 10 degrees. Keywords: in vitro culture, oocyte, cattle nuclear transfer, electrofusion, enucleation.

This paper proposes an approach for a 3D-Piezo Compensation Mechanism unit that is capable of fast and accurate adaption of the spindle position to enhance machining by robots. The mechanical design is explained which focuses on low mass, good stiffness and high bandwidth in order to allow compensating for errors beyond the bandwidth of the robot. In addition to previous works [7,9], an advanced actuation design is presented enabling movements in three translational axes allowing a working range of each axis up to half a millimeter. Based on the presented theoretical dimensioning and finite element simulation translational moves with higher bandwidth can be enabled, due to the parallel design approach of a 3D-Piezo Compensation Mechanism. For realization aspects piezo actuators are chosen due to their fast dynamics and high forces. The realization of the control loop is further outlined. In order to enable a good control performance the set-up of sensing the extension of the piezo actuator is detailed as well as the spindle position used in fast real-time environment. As a result the 3D-Piezo Compensation mechanism unit allows an active adaption of the spindle position in the range of micrometers. A description of the deployment of the compensation unit to a robot machining system as well as first experimental results conclude the paper and prove the proper functioning of the approach and outline the potential of the entire system. Measured robot paths are applied to the compensation unit and analyzed with respect to the reduction of robot path errors.

The conversion units and data transfer with frequency data coding are perspective for a reliability raising and transmission accuracy of the information in control systems, communication systems, computer networks etc. One of directions in creation of high-reliable microelectronic components of computer facilities and control systems is the development of multifunction frequency elements on the basis of nonlinear resonant circuits (NRC). The multifunctionality of such elements at their schematic simplicity is determined not by a number of components and complexity of structural organization (as in large integrated circuits), and purposeful usage of numerous effects having a place in nonlinear vibratory circuits. The results, obtained by the authors, gain the significance in modern conditions, when the semiconducting production process of large integrated circuits for microprocessors practically has reached a physical limit of decreasing the sizes of components and width of interconnections. Alternative can be only usage of artificial intelligence systems, the elements of the multivalued logic on the basis NRC can be applied to their construction. Experimental samples of such elements have been realized in the form of thin-film microcircuits in a standard body.

Функціональну коморбідність серцево-судинної і травної систем необхідно врахо-вувати при змішаному харчуванні і призначеннімедикаментозної терапії.