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152. Associations between ongoing COVID‐19 lockdown and the financial and mental health experiences of Australian families.

Author

Price, Anna M. H., Contreras‐Suárez, Diana, Zhu, Anna, Schreurs, Natalie, Measey, Mary‐Anne, Woolfenden, Sue, Burley, Jade, Bryson, Hannah, Efron, Daryl, Rhodes, Anthea, and Goldfeld, Sharon

Subjects
*CAREGIVERS, *SCHOOL children, *MENTAL health, *STAY-at-home orders, *NUCLEAR families, *CHILDREN'S hospitals, *COVID-19
Abstract

In 2020, Australia's successful COVID‐19 public health restrictions comprised a national "initial lockdown" (March–May) and "ongoing lockdown" (July–November) for metropolitan Victorian residents only. We evaluated associations between ongoing lockdown and family finances and mental health. In the June and September 2020 Royal Children's Hospital National Child Health Polls, caregivers of children in Victoria and New South Wales (NSW) reported the following: job/income loss; material deprivation (inability to pay for essential items); income poverty; mental health (Kessler‐6); perceived impact on caregiver/child mental health; and caregiver/child coping. Data from caregivers (N = 1207/902) in June/September were analysed using difference‐in‐difference modelling (NSW provided the comparator). During Victoria's ongoing lockdown, job/income loss increased by 11% (95%CI: 3%–18%); Kessler‐6 poor mental health by 6% (95%CI: −0.3%–12%) and perceived negative mental health impacts by 14% for caregivers (95%CI: 6%–23%) and 12% for children (95%CI: 4%–20%). Female (vs. male) caregivers, metropolitan (vs. regional/rural) families, and families with elementary school‐aged children (vs. pre‐/high‐school) were the most affected. The ongoing lockdown was associated with negative experiences of mental health, employment and income, but not deprivation or poverty, likely because of government income supplements introduced early in the pandemic. Future lockdowns require planned responses to outbreaks and evidence‐informed financial and mental health supports. [ABSTRACT FROM AUTHOR]

Published
2023
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153. Parenting roles for young people with attention‐deficit/hyperactivity disorder transitioning to adult services.

Author

Janssens, Astrid, Blake, Sharon, Eke, Helen, Price, Anna, and Ford, Tamsin

Subjects
YOUNG adults, TRANSITIONAL care, ATTENTION-deficit hyperactivity disorder, PARENTING, CHILD health services
Abstract

Aim: To inform transitions from child to adult health services, we explored the work and roles parents take in the care of young people with attention‐deficit/hyperactivity disorder (ADHD) aged 14 to 25 years old. Method: Using framework thematic analysis, we analysed data collected from 28 semi‐structured interviews with parents of young people with ADHD to generate a typology and triangulated it against findings from 64 interviews with young people with ADHD. The interviews were carried out as part of a three‐strand, interactive mixed‐method study. Results: An entourage typology of three parent roles was identified. Parents moved between 'manager' and 'roadie' roles as their child gradually matured. A 'superfan' role was identified which supported young people's positive self‐image but may impede withdrawal from the 'manager' role. Continued parental involvement into adulthood reflected a need to maintain the balance of resources required to maintain quality of life for the whole family. Interpretation: This is the first study to explore parental roles in the health care of young people with ADHD. Parents will vary in their capacity to fulfil the identified roles and step back their care as their children reach adulthood. The findings can inform intervention development to support families and transition between services. What this paper adds: Parents move from a 'manager' to 'roadie' role as young people mature.A 'superfan' role supports positive self‐image and directed health care work.Continued involvement reflects parental responsibility to juggle wider family needs and resources.Parents differ in capacity to fulfil and move between these roles. [ABSTRACT FROM AUTHOR]

Published
2023
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155. Economic evaluation of an Australian nurse home visiting programme: a randomised trial at 3 years

Author

Bohingamu Mudiyanselage, Shalika, primary, Price, Anna M H, additional, Mensah, Fiona K, additional, Bryson, Hannah E, additional, Perlen, Susan, additional, Orsini, Francesca, additional, Hiscock, Harriet, additional, Dakin, Penelope, additional, Harris, Diana, additional, Noble, Kristy, additional, Bruce, Tracey, additional, Kemp, Lynn, additional, Goldfeld, Sharon, additional, and Gold, Lisa, additional

Published
2021
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156. Connecting healthcare with income maximisation services, and their financial, health and well-being impacts for families with young children: a systematic review protocol

Author

Burley, Jade, primary, Price, Anna MH, additional, Parker, Anneka, additional, Samir, Nora, additional, Zhu, Anna, additional, Eapen, Valsamma, additional, Contreras-Suarez, Diana, additional, Schreurs, Natalie, additional, Lawson, K D, additional, Lingam, Raghu, additional, Grace, Rebekah, additional, Raman, Shanti, additional, Kemp, Lynn, additional, Chota, Sumayya, additional, Goldfeld, Sharon, additional, and Woolfenden, Susan, additional

Published
2021
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157. Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease

Author

Edwards, Nicola C., primary, Price, Anna M., additional, Mehta, Samir, additional, Hiemstra, Thomas F., additional, Kaur, Amreen, additional, Greasley, Peter J., additional, Webb, David J., additional, Dhaun, Neeraj, additional, MacIntyre, Iain M., additional, Farrah, Tariq, additional, Melville, Vanessa, additional, Herrey, Anna S., additional, Slinn, Gemma, additional, Wale, Rebekah, additional, Ives, Natalie, additional, Wheeler, David C., additional, Wilkinson, Ian, additional, Steeds, Richard P., additional, Ferro, Charles J., additional, and Townend, Jonathan N., additional

Published
2021
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158. 25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth

Author

Marx-Stoelting, Philip, Solano, Marize de L.M., Aoyama, Hiroaki, Adams, Ralf H., Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L., Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, and Solecki, Roland

Published
2021
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159. SARS-CoV-2 within-host diversity and transmission

Author

Lythgoe, Katrina A., Hall, Matthew, Ferretti, Luca, de Cesare, Mariateresa, MacIntyre-Cockett, George, Trebes, Amy, Andersson, Monique, Otecko, Newton, Wise, Emma L., Moore, Nathan, Lynch, Jessica, Kidd, Stephen, Cortes, Nicholas, Mori, Matilde, Williams, Rebecca, Vernet, Gabrielle, Justice, Anita, Green, Angie, Nicholls, Samuel M., Ansari, M. Azim, Abeler-Dörner, Lucie, Moore, Catrin E., Peto, Timothy E. A., Eyre, David W., Shaw, Robert, Simmonds, Peter, Buck, David, Todd, John A., Connor, Thomas R., Ashraf, Shirin, da Silva Filipe, Ana, Shepherd, James, Thomson, Emma C., Bonsall, David, Fraser, Christophe, Golubchik, Tanya, The COVID-19 Genomics UK (COG-UK) Consortium, Bresner, Catherine, Fuller, William, Guest, Martyn, Kitchen, Christine, Marchbank, Angela, Merrick, Ian, Munn, Robert, Price, Anna, Southgate, Joel, Workman, Trudy, (OVSG), Oxford Virus Sequencing Analysis Group, consortium, The COVID-19 Genomics UK (COG-UK), Lythgoe, Katrina A [0000-0002-7089-7680], Hall, Matthew [0000-0002-2671-3864], Ferretti, Luca [0000-0001-7578-7301], de Cesare, Mariateresa [0000-0002-9847-1526], Trebes, Amy [0000-0002-3715-9109], Andersson, Monique [0000-0003-0619-1074], Wise, Emma L [0000-0002-0279-3900], Moore, Nathan [0000-0002-4279-2443], Lynch, Jessica [0000-0003-2015-9986], Kidd, Stephen [0000-0002-4504-4600], Mori, Matilde [0000-0001-9012-1911], Williams, Rebecca [0000-0002-8557-6337], Vernet, Gabrielle [0000-0001-9887-2824], Green, Angie [0000-0003-4386-9972], Nicholls, Samuel M [0000-0003-4081-065X], Ansari, M Azim [0000-0003-2790-8353], Abeler-Dörner, Lucie [0000-0003-3662-4192], Moore, Catrin E [0000-0002-8639-9846], Peto, Timothy EA [0000-0003-3477-8307], Shaw, Robert [0000-0003-3449-5876], Todd, John A [0000-0003-2740-8148], Connor, Thomas R [0000-0003-2394-6504], Ashraf, Shirin [0000-0002-6468-0258], da Silva Filipe, Ana [0000-0002-9442-2903], Shepherd, James [0000-0003-3915-048X], Thomson, Emma C [0000-0003-1482-0889], Bonsall, David [0000-0003-2187-0550], Fraser, Christophe [0000-0003-2399-9657], Golubchik, Tanya [0000-0003-2765-9828], and Apollo - University of Cambridge Repository

Subjects
Evolution, B100, B200, Genome, Viral, Biology, Virus, Bottleneck, law.invention, Coronavirus OC43, Human, 03 medical and health sciences, Phylogenetics, law, Pandemic, Humans, Online, RNA-Seq, Selection, Genetic, Research Articles, Phylogeny, 030304 developmental biology, Immune Evasion, 0303 health sciences, Family Characteristics, Multidisciplinary, Phylogenetic tree, 030306 microbiology, Coinfection, SARS-CoV-2, R-Articles, COVID-19, Genetic Variation, Microbio, Viral Load, C700, United Kingdom, Transmission (mechanics), Evolutionary biology, Mutation (genetic algorithm), Mutation, Spike Glycoprotein, Coronavirus, RNA, Viral, Coronavirus Infections, Viral load, Research Article
Abstract

Patterns and bottlenecks A year into the severe acute respiratory syndrome coronavirus 2 pandemic, we are experiencing waves of new variants emerging. Some of these variants have worrying functional implications, such as increased transmissibility or antibody treatment escape. Lythgoe et al. have undertaken in-depth sequencing of more than 1000 hospital patients' isolates to find out how the virus is mutating within individuals. Overall, there seem to be consistent and reproducible patterns of within-host virus diversity. The authors observed only one or two variants in most samples, but a few carried many variants. Although the evidence indicates strong purifying selection, including in the spike protein responsible for viral entry, the authors also saw evidence for transmission clusters associated with households and other possible superspreader events. After transmission, most variants fizzled out, but occasionally some initiated ongoing transmission and wider dissemination. Science, this issue p. eabg0821, More than a thousand deep-sequenced clinical samples from the UK reveal that SARS-CoV-2 has limited genetic diversity within most individuals., INTRODUCTION Genome sequencing at an unprecedented scale during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is helping to track spread of the virus and to identify new variants. Most of this work considers a single consensus sequence for each infected person. Here, we looked beneath the consensus to analyze genetic variation within viral populations making up an infection and studied the fate of within-host mutations when an infection is transmitted to a new individual. Within-host diversity offers the means to help confirm direct transmission and identify new variants of concern. RATIONALE We sequenced 1313 SARS-CoV-2 samples from the first wave of infection in the United Kingdom. We characterized within-host diversity and dynamics in the context of transmission and ongoing viral evolution. RESULTS Within-host diversity can be described by the number of intrahost single nucleotide variants (iSNVs) occurring above a given minor allele frequency (MAF) threshold. We found that in lower-viral-load samples, stochastic sampling effects resulted in a higher variance in MAFs, leading to more iSNVs being detected at any threshold. Based on a subset of 27 pairs of high-viral-load replicate RNA samples (>50,000 uniquely mapped veSEQ reads, corresponding to a cycle threshold of ~22), iSNVs with a minimum 3% MAF were highly reproducible. Comparing samples from two time points from 41 individuals, taken on average 6 days apart (interquartile ratio 2 to 10), we observed a dynamic process of iSNV generation and loss. Comparing iSNVs among 14 household contact pairs, we estimated transmission bottleneck sizes of one to eight viruses. Consensus differences between individuals in the same household, where sample depth allowed iSNV detection, were explained by the presence of an iSNV at the same site in the paired individual, consistent with direct transmission leading to fixation. We next focused on a set of 563 high-confidence iSNV sites that were variant in at least one high-viral-load sample (>50,000 uniquely mapped); low-confidence iSNVs unlikely to represent genomic diversity were excluded. Within-host diversity was limited in high-viral-load samples (mean 1.4 iSNVs per sample). Two exceptions, each with >14 iSNVs, showed variant frequencies consistent with coinfection or contamination. Overall, we estimated that 1 to 2% of samples in our dataset were coinfected and/or contaminated. Additionally, one sample was coinfected with another coronavirus (OC43), with no detectable impact on diversity. The ratio of nonsynonymous to synonymous (dN/dS) iSNVs was consistent with within-host purifying selection when estimated across the whole genome [dN/dS = 0.55, 95% confidence interval (95% CI) = 0.49 to 0.61] and for the Spike gene (dN/dS = 0.60, 95% CI = 0.45 to 0.82). Nevertheless, we observed Spike variants in multiple samples that have been shown to increase viral infectivity (L5F) or resistance to antibodies (G446V and A879V). We observed a strong association between high-confidence iSNVs and a consensus change on the phylogeny (153 cases), consistent with fixation after transmission or de novo mutations reaching consensus. Shared variants that never reached consensus (261 cases) were not phylogenetically associated. CONCLUSION Using robust methods to call within-host variants, we uncovered a consistent pattern of low within-host diversity, purifying selection, and narrow transmission bottlenecks. Within-host emergence of vaccine and therapeutic escape mutations is likely to be relatively rare, at least during early infection, when viral loads are high, but the observation of immune-escape variants in high-viral-load samples underlines the need for continued vigilance. Diagram showing low SARS-CoV-2 within-host genetic diversity and narrow transmission bottleneck. Individuals with high viral load typically have few, if any, within-host variants. Narrow transmission bottlenecks mean that the major variant in the source individual was typically transmitted and the minor variants lost. Occasionally, the minor variant was transmitted, leading to a consensus change, or multiple variants were transmitted, resulting in a mixed infection. Credit: FontAwesome, licensed under CC BY 4.0., Extensive global sampling and sequencing of the pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have enabled researchers to monitor its spread and to identify concerning new variants. Two important determinants of variant spread are how frequently they arise within individuals and how likely they are to be transmitted. To characterize within-host diversity and transmission, we deep-sequenced 1313 clinical samples from the United Kingdom. SARS-CoV-2 infections are characterized by low levels of within-host diversity when viral loads are high and by a narrow bottleneck at transmission. Most variants are either lost or occasionally fixed at the point of transmission, with minimal persistence of shared diversity, patterns that are readily observable on the phylogenetic tree. Our results suggest that transmission-enhancing and/or immune-escape SARS-CoV-2 variants are likely to arise infrequently but could spread rapidly if successfully transmitted.

Published
2021

160. Mating advantage for rare males in wild guppy populations

Author

Hughes, Kimberly A., Houde, Anne E., Price, Anna C., and Rodd, F. Helen

Subjects
Genetic polymorphisms -- Research, Population genetics -- Research, Evolutionary biology -- Research, Sexual selection in animals -- Research, Guppies -- Physiological aspects -- Genetic aspects -- Demographic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

To understand the processes that maintain genetic diversity is a long-standing challenge in evolutionary biology, with implications for predicting disease resistance, response to environmental change, and population persistence (1-3). Simple population genetic models are not sufficient to explain the high levels of genetic diversity sometimes observed in ecologically important traits (2). In guppies (Poecilia reticulata), male colour pattern is both diverse and heritable, and is arguably one of the most extreme examples of morphological polymorphism known (4,5). Negative frequency-dependent selection (NFDS), a form of selection in which genotypes are favoured when they are rare (6), can potentially maintain such extensive polymorphism, but few experimental studies have confirmed its operation in nature (7,8). Here we use highly replicated experimental manipulations of natural populations to show that males with rare colour patterns have higher reproductive fitness, demonstrating NFDS mediated by sexual selection. Rare males acquired more mates and sired more offspring compared to common males and, as previously reported, had higher rates of survival (8). Orange colour, implicated in other studies of sexual selection in guppies, did predict male reproductive success, but only in one of three populations. These data support the hypothesis that NFDS maintains diversity in the colour patterns of male guppies through two selective agents, mates and predators. Similar field-based manipulations of genotype frequencies could provide a powerful approach to reveal the underlying ecological and behavioural mechanisms that maintain genetic and phenotypic diversity., Populations of organisms exhibit enormous genetic diversity. Explaining this diversity has been challenging, particularly when variation occurs in traits under strong natural selection (1,3). High genetic variation in ecologically important [...]

Published
2013
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163. Clinical, financial and social impacts of COVID-19 and their associations with mental health for mothers and children experiencing adversity in Australia

Author

Bryson, Hannah, primary, Mensah, Fiona, additional, Price, Anna, additional, Gold, Lisa, additional, Mudiyanselage, Shalika Bohingamu, additional, Kenny, Bridget, additional, Dakin, Penelope, additional, Bruce, Tracey, additional, Noble, Kristy, additional, Kemp, Lynn, additional, and Goldfeld, Sharon, additional

Published
2021
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168. An inter-laboratory case study to determine the added value of the Zebrafish Light-dark transition test to predict developmental neurotoxicity

Author

Alzualde, Ainhoa, Hsieh, Jui-Hua, Ellis, Lee, Schiavone, Valentina, Truong, Lisa, Legradi, Jessica, Rubbini, Davide, Woodland, Cindy, Kl��ver, Nils, Ryan, Kristen, Behl, Mamta, Terriente, Javier, Muriana, Arantza, Tanguay, Robyn L., Sachana, Magdalini, Price, Anna, Hill, Bridgett, Padilla, Stephanie, Shafer, Timothy, and Hessel, Ellen

Subjects
Toxicology
Abstract

Poster presented to the European Society of Environmental Toxicology and Chemistry (SETAC) meeting May 2021Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Published
2021
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169. Towards a systematic use of effect biomarkers in population and occupational biomonitoring

Author

Zare Jeddi, Maryam, Hopf, Nancy B., Viegas, Susana, Price, Anna Bal, Paini, Alicia, van Thriel, Christoph, Benfenati, Emilio, Ndaw, Sophie, Bessems, Jos, Behnisch, Peter A., Leng, Gabriele, Duca, Radu Corneliu, Verhagen, Hans, Cubadda, Francesco, Brennan, Lorraine, Ali, Imran, David, Arthur, Mustieles, Vicente, Fernandez, Mariana F., Louro, Henriqueta, Pasanen-Kase, Robert, Escola Nacional de Saúde Pública (ENSP), Centro de Investigação em Saúde Pública (CISP/PHRC), Comprehensive Health Research Centre (CHRC) - Pólo ENSP, Centre for Toxicogenomics and Human Health (ToxOmics), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Mixture assessment, SDG 3 - Good Health and Well-being, Adverse outcome pathways (AOP), Environmental Science(all), Biomonitoring, Physiologically based pharmacokinetic (PBPK), Exposure science, Risk assessment
Abstract

Effect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to provide an overview of available effect biomarkers for monitoring chemical exposures in the general and occupational populations, and highlight their potential in monitoring humans exposed to chemical mixtures. We also discuss the role of the adverse outcome pathway (AOP) framework and physiologically based kinetic and dynamic (PBK/D) modelling to strengthen the understanding of the biological mechanism of effect biomarkers, and in particular for use in regulatory risk assessments. An interdisciplinary network of experts from the European chapter of the International Society for Exposure Science (ISES Europe) and the Organization for Economic Co-operation and Development (OECD) Occupational Biomonitoring activity of Working Parties of Hazard and Exposure Assessment group worked together to map the conventional framework of biomarkers and provided recommendations for their systematic use. We summarized the key aspects of this work here, and discussed these in three parts. Part I, we inventory available effect biomarkers and promising new biomarkers for the general population based on the H2020 Human Biomonitoring for Europe (HBM4EU) initiative. Part II, we provide an overview AOP and PBK/D modelling use that improved the selection and interpretation of effect biomarkers. Part III, we describe the collected expertise from the OECD Occupational Biomonitoring subtask effect biomarkers in prioritizing relevant mode of actions (MoAs) and suitable effect biomarkers. Furthermore, we propose a tiered risk assessment approach for occupational biomonitoring. Several effect biomarkers, especially for use in occupational settings, are validated. They offer a direct assessment of the overall health risks associated with exposure to chemicals, chemical mixtures and their transformation products. Promising novel effect biomarkers are emerging for biomonitoring of the general population. Efforts are being dedicated to prioritizing molecular and biochemical effect biomarkers that can provide a causal link in exposure-health outcome associations. This mechanistic approach has great potential in improving human health risk assessment. New techniques such as in silico methods (e.g. QSAR, PBK/D modelling) as well as ‘omics data will aid this process. Our multidisciplinary review represents a starting point for enhancing the identification of effect biomarkers and their mechanistic pathways following the AOP framework. This may help in prioritizing the effect biomarker implementation as well as defining threshold limits for chemical mixtures in a more structured way. Several ex vivo biomarkers have been proposed to evaluate combined effects including genotoxicity and xeno-estrogenicity. There is a regulatory need to derive effect-based trigger values using the increasing mechanistic knowledge coming from the AOP framework to address adverse health effects due to exposure to chemical mixtures. Such a mechanistic strategy would reduce the fragmentation observed in different regulations. It could also stimulate a harmonized use of effect biomarkers in a more comparable way, in particular for risk assessments to chemical mixtures. publishersversion published

Published
2021

170. 25th anniversary of the Berlin Workshop on Developmental Toxicology:DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth

Author

Marx-Stoelting, Philip, Solano, Marize de L M, Aoyama, Hiroaki, Adams, Ralf H, Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L, Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, Solecki, Rol, Marx-Stoelting, Philip, Solano, Marize de L M, Aoyama, Hiroaki, Adams, Ralf H, Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L, Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, and Solecki, Rol

Abstract

25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together international experts from authorities, academia and industry to consider scientific, methodologic and regulatory aspects in risk assessment of developmental toxicity and to debate alternative strategies in testing developmental effects in the future. Proposals for improvement of the categorization of developmental effects were discussed as well as the update of the DevTox database as valuable tool for harmonization. The development of adverse outcome pathways relevant to developmental neurotoxicity (DNT) was debated as a fundamental improvement to guide the screening and testing for DNT using alternatives to animal methods. A further focus was the implementation of an in vitro mechanism-based battery, which can support various regulatory applications associated with the assessment of chemicals and mixtures. More interdisciplinary and translation research should be initiated to accelerate the development of new technologies to test developmental toxicity. Technologies in the pipeline are (i) high throughput imaging techniques, (ii) models for DNT screening tests, (iii) use of computer tomography for assessment of thoracolumbar supernumerary ribs in animal models, and (iv) 3D biofabrication of bone development and regeneration tissue models. In addition, increased collaboration with the medical community was suggested to improve the relevance of test results to humans and identify more clinically relevant endpoints. Finally, the participants agreed that this conference facilitated better understanding innovative approaches that can be useful for the identification of developmental health risks due to exposure to chemical substances.

Published
2021

175. Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

Author

Adler, Sarah, Basketter, David, Creton, Stuart, Pelkonen, Olavi, van Benthem, Jan, Zuang, Valérie, Andersen, Klaus Ejner, Angers-Loustau, Alexandre, Aptula, Aynur, Bal-Price, Anna, Benfenati, Emilio, Bernauer, Ulrike, Bessems, Jos, Bois, Frederic Y., Boobis, Alan, Brandon, Esther, Bremer, Susanne, Broschard, Thomas, Casati, Silvia, Coecke, Sandra, Corvi, Raffaella, Cronin, Mark, Daston, George, Dekant, Wolfgang, Felter, Susan, Grignard, Elise, Gundert-Remy, Ursula, Heinonen, Tuula, Kimber, Ian, Kleinjans, Jos, Komulainen, Hannu, Kreiling, Reinhard, Kreysa, Joachim, Leite, Sofia Batista, Loizou, George, Maxwell, Gavin, Mazzatorta, Paolo, Munn, Sharon, Pfuhler, Stefan, Phrakonkham, Pascal, Piersma, Aldert, Poth, Albrecht, Prieto, Pilar, Repetto, Guillermo, Rogiers, Vera, Schoeters, Greet, Schwarz, Michael, Serafimova, Rositsa, Tähti, Hanna, Testai, Emanuela, van Delft, Joost, van Loveren, Henk, Vinken, Mathieu, Worth, Andrew, and Zaldivar, José-Manuel

Published
2011
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182. Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Author

Meng, Bo, primary, Kemp, Steven A., additional, Papa, Guido, additional, Datir, Rawlings, additional, Ferreira, Isabella A.T.M., additional, Marelli, Sara, additional, Harvey, William T., additional, Lytras, Spyros, additional, Mohamed, Ahmed, additional, Gallo, Giulia, additional, Thakur, Nazia, additional, Collier, Dami A., additional, Mlcochova, Petra, additional, Duncan, Lidia M., additional, Carabelli, Alessandro M., additional, Kenyon, Julia C., additional, Lever, Andrew M., additional, De Marco, Anna, additional, Saliba, Christian, additional, Culap, Katja, additional, Cameroni, Elisabetta, additional, Matheson, Nicholas J., additional, Piccoli, Luca, additional, Corti, Davide, additional, James, Leo C., additional, Robertson, David L., additional, Bailey, Dalan, additional, Gupta, Ravindra K., additional, Robson, Samuel C., additional, Loman, Nicholas J., additional, Connor, Thomas R., additional, Golubchik, Tanya, additional, Martinez Nunez, Rocio T., additional, Ludden, Catherine, additional, Corden, Sally, additional, Johnston, Ian, additional, Bonsall, David, additional, Smith, Colin P., additional, Awan, Ali R., additional, Bucca, Giselda, additional, Torok, M. Estee, additional, Saeed, Kordo, additional, Prieto, Jacqui A., additional, Jackson, David K., additional, Hamilton, William L., additional, Snell, Luke B., additional, Moore, Catherine, additional, Harrison, Ewan M., additional, Goncalves, Sonia, additional, Fairley, Derek J., additional, Loose, Matthew W., additional, Watkins, Joanne, additional, Livett, Rich, additional, Moses, Samuel, additional, Amato, Roberto, additional, Nicholls, Sam, additional, Bull, Matthew, additional, Smith, Darren L., additional, Barrett, Jeff, additional, Aanensen, David M., additional, Curran, Martin D., additional, Parmar, Surendra, additional, Aggarwal, Dinesh, additional, Shepherd, James G., additional, Parker, Matthew D., additional, Glaysher, Sharon, additional, Bashton, Matthew, additional, Underwood, Anthony P., additional, Pacchiarini, Nicole, additional, Loveson, Katie F., additional, Templeton, Kate E., additional, Langford, Cordelia F., additional, Sillitoe, John, additional, de Silva, Thushan I., additional, Wang, Dennis, additional, Kwiatkowski, Dominic, additional, Rambaut, Andrew, additional, O’Grady, Justin, additional, Cottrell, Simon, additional, Holden, Matthew T.G., additional, Thomson, Emma C., additional, Osman, Husam, additional, Andersson, Monique, additional, Chauhan, Anoop J., additional, Hassan-Ibrahim, Mohammed O., additional, Lawniczak, Mara, additional, Alderton, Alex, additional, Chand, Meera, additional, Constantinidou, Chrystala, additional, Unnikrishnan, Meera, additional, Darby, Alistair C., additional, Hiscox, Julian A., additional, Paterson, Steve, additional, Martincorena, Inigo, additional, Volz, Erik M., additional, Page, Andrew J., additional, Pybus, Oliver G., additional, Bassett, Andrew R., additional, Ariani, Cristina V., additional, Chapman, Michael H. Spencer, additional, Li, Kathy K., additional, Shah, Rajiv N., additional, Jesudason, Natasha G., additional, Taha, Yusri, additional, McHugh, Martin P., additional, Dewar, Rebecca, additional, Jahun, Aminu S., additional, McMurray, Claire, additional, Pandey, Sarojini, additional, McKenna, James P., additional, Nelson, Andrew, additional, Young, Gregory R., additional, McCann, Clare M., additional, Elliott, Scott, additional, Lowe, Hannah, additional, Temperton, Ben, additional, Roy, Sunando, additional, Price, Anna, additional, Rey, Sara, additional, Wyles, Matthew, additional, Rooke, Stefan, additional, Shaaban, Sharif, additional, de Cesare, Mariateresa, additional, Letchford, Laura, additional, Silveira, Siona, additional, Pelosi, Emanuela, additional, Wilson-Davies, Eleri, additional, Hosmillo, Myra, additional, O’Toole, Áine, additional, Hesketh, Andrew R., additional, Stark, Richard, additional, du Plessis, Louis, additional, Ruis, Chris, additional, Adams, Helen, additional, Bourgeois, Yann, additional, Michell, Stephen L., additional, Grammatopoulos, Dimitris, additional, Edgeworth, Jonathan, additional, Breuer, Judith, additional, Todd, John A., additional, Fraser, Christophe, additional, Buck, David, additional, John, Michaela, additional, Kay, Gemma L., additional, Palmer, Steve, additional, Peacock, Sharon J., additional, Heyburn, David, additional, Weldon, Danni, additional, Robinson, Esther, additional, McNally, Alan, additional, Muir, Peter, additional, Vipond, Ian B., additional, Boyes, John, additional, Sivaprakasam, Venkat, additional, Salluja, Tranprit, additional, Dervisevic, Samir, additional, Meader, Emma J., additional, Park, Naomi R., additional, Oliver, Karen, additional, Jeffries, Aaron R., additional, Ott, Sascha, additional, da Silva Filipe, Ana, additional, Simpson, David A., additional, Williams, Chris, additional, Masoli, Jane A.H., additional, Knight, Bridget A., additional, Jones, Christopher R., additional, Koshy, Cherian, additional, Ash, Amy, additional, Casey, Anna, additional, Bosworth, Andrew, additional, Ratcliffe, Liz, additional, Xu-McCrae, Li, additional, Pymont, Hannah M., additional, Hutchings, Stephanie, additional, Berry, Lisa, additional, Jones, Katie, additional, Halstead, Fenella, additional, Davis, Thomas, additional, Holmes, Christopher, additional, Iturriza-Gomara, Miren, additional, Lucaci, Anita O., additional, Randell, Paul Anthony, additional, Cox, Alison, additional, Madona, Pinglawathee, additional, Harris, Kathryn Ann, additional, Brown, Julianne Rose, additional, Mahungu, Tabitha W., additional, Irish-Tavares, Dianne, additional, Haque, Tanzina, additional, Hart, Jennifer, additional, Witele, Eric, additional, Fenton, Melisa Louise, additional, Liggett, Steven, additional, Graham, Clive, additional, Swindells, Emma, additional, Collins, Jennifer, additional, Eltringham, Gary, additional, Campbell, Sharon, additional, McClure, Patrick C., additional, Clark, Gemma, additional, Sloan, Tim J., additional, Jones, Carl, additional, Lynch, Jessica, additional, Warne, Ben, additional, Leonard, Steven, additional, Durham, Jillian, additional, Williams, Thomas, additional, Haldenby, Sam T., additional, Storey, Nathaniel, additional, Alikhan, Nabil-Fareed, additional, Holmes, Nadine, additional, Moore, Christopher, additional, Carlile, Matthew, additional, Perry, Malorie, additional, Craine, Noel, additional, Lyons, Ronan A., additional, Beckett, Angela H., additional, Goudarzi, Salman, additional, Fearn, Christopher, additional, Cook, Kate, additional, Dent, Hannah, additional, Paul, Hannah, additional, Davies, Robert, additional, Blane, Beth, additional, Girgis, Sophia T., additional, Beale, Mathew A., additional, Bellis, Katherine L., additional, Dorman, Matthew J., additional, Drury, Eleanor, additional, Kane, Leanne, additional, Kay, Sally, additional, McGuigan, Samantha, additional, Nelson, Rachel, additional, Prestwood, Liam, additional, Rajatileka, Shavanthi, additional, Batra, Rahul, additional, Williams, Rachel J., additional, Kristiansen, Mark, additional, Green, Angie, additional, Justice, Anita, additional, Mahanama, Adhyana I.K., additional, Samaraweera, Buddhini, additional, Hadjirin, Nazreen F., additional, Quick, Joshua, additional, Poplawski, Radoslaw, additional, Kermack, Leanne M., additional, Reynolds, Nicola, additional, Hall, Grant, additional, Chaudhry, Yasmin, additional, Pinckert, Malte L., additional, Georgana, Iliana, additional, Moll, Robin J., additional, Thornton, Alicia, additional, Myers, Richard, additional, Stockton, Joanne, additional, Williams, Charlotte A., additional, Yew, Wen C., additional, Trotter, Alexander J., additional, Trebes, Amy, additional, MacIntyre-Cockett, George, additional, Birchley, Alec, additional, Adams, Alexander, additional, Plimmer, Amy, additional, Gatica-Wilcox, Bree, additional, McKerr, Caoimhe, additional, Hilvers, Ember, additional, Jones, Hannah, additional, Asad, Hibo, additional, 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Southgate, Joel, additional, Lindsey, Benjamin B., additional, Freeman, Timothy M., additional, Keatley, Jon-Paul, additional, Singer, Joshua B., additional, de Oliveira Martins, Leonardo, additional, Yeats, Corin A., additional, Abudahab, Khalil, additional, Taylor, Ben E.W., additional, Menegazzo, Mirko, additional, Danesh, John, additional, Hogsden, Wendy, additional, Eldirdiri, Sahar, additional, Kenyon, Anita, additional, Mason, Jenifer, additional, Robinson, Trevor I., additional, Holmes, Alison, additional, Price, James, additional, Hartley, John A., additional, Curran, Tanya, additional, Mather, Alison E., additional, Shankar, Giri, additional, Jones, Rachel, additional, Howe, Robin, additional, Morgan, Sian, additional, Wastenge, Elizabeth, additional, Chapman, Michael R., additional, Mookerjee, Siddharth, additional, Stanley, Rachael, additional, Smith, Wendy, additional, Peto, Timothy, additional, Eyre, David, additional, Crook, Derrick, additional, Vernet, Gabrielle, additional, Kitchen, Christine, additional, Gulliver, Huw, additional, Merrick, Ian, additional, Guest, Martyn, additional, Munn, Robert, additional, Bradley, Declan T., additional, Wyatt, Tim, additional, Beaver, Charlotte, additional, Foulser, Luke, additional, Palmer, Sophie, additional, Churcher, Carol M., additional, Brooks, Ellena, additional, Smith, Kim S., additional, Galai, Katerina, additional, McManus, Georgina M., additional, Bolt, Frances, additional, Coll, Francesc, additional, Meadows, Lizzie, additional, Attwood, Stephen W., additional, Davies, Alisha, additional, De Lacy, Elen, additional, Downing, Fatima, additional, Edwards, Sue, additional, Scarlett, Garry P., additional, Jeremiah, Sarah, additional, Smith, Nikki, additional, Leek, Danielle, additional, Sridhar, Sushmita, additional, Forrest, Sally, additional, Cormie, Claire, additional, Gill, Harmeet K., additional, Dias, Joana, additional, Higginson, Ellen E., additional, Maes, Mailis, additional, Young, Jamie, additional, Wantoch, Michelle, additional, Jamrozy, Dorota, additional, Lo, Stephanie, additional, Patel, Minal, additional, Hill, Verity, additional, Bewshea, Claire M., additional, Ellard, Sian, additional, Auckland, Cressida, additional, Harrison, Ian, additional, Bishop, Chloe, additional, Chalker, Vicki, additional, Richter, Alex, additional, Beggs, Andrew, additional, Best, Angus, additional, Percival, Benita, additional, Mirza, Jeremy, additional, Megram, Oliver, additional, Mayhew, Megan, additional, Crawford, Liam, additional, Ashcroft, Fiona, additional, Moles-Garcia, Emma, additional, Cumley, Nicola, additional, Hopes, Richard, additional, Asamaphan, Patawee, additional, Niebel, Marc O., additional, Gunson, Rory N., additional, Bradley, Amanda, additional, Maclean, Alasdair, additional, Mollett, Guy, additional, Blacow, Rachel, additional, Bird, Paul, additional, Helmer, Thomas, additional, Fallon, Karlie, additional, Tang, Julian, additional, Hale, Antony D., additional, Macfarlane-Smith, Louissa R., additional, Harper, Katherine L., additional, Carden, Holli, additional, Machin, Nicholas W., additional, Jackson, Kathryn A., additional, Ahmad, Shazaad S.Y., additional, George, Ryan P., additional, Turtle, Lance, additional, O’Toole, Elaine, additional, Watts, Joanne, additional, Breen, Cassie, additional, Cowell, Angela, additional, Alcolea-Medina, Adela, additional, Charalampous, Themoula, additional, Patel, Amita, additional, Levett, Lisa J., additional, Heaney, Judith, additional, Rowan, Aileen, additional, Taylor, Graham P., additional, Shah, Divya, additional, Atkinson, Laura, additional, Lee, Jack C.D., additional, Westhorpe, Adam P., additional, Jannoo, Riaz, additional, Lowe, Helen L., additional, Karamani, Angeliki, additional, Ensell, Leah, additional, Chatterton, Wendy, additional, Pusok, Monika, additional, Dadrah, Ashok, additional, Symmonds, Amanda, additional, Sluga, Graciela, additional, Molnar, Zoltan, additional, Baker, Paul, additional, Bonner, Stephen, additional, Essex, Sarah, additional, Barton, Edward, additional, Padgett, Debra, additional, Scott, Garren, additional, Greenaway, Jane, additional, Payne, Brendan A.I., additional, Burton-Fanning, Shirelle, additional, Waugh, Sheila, additional, Raviprakash, Veena, additional, Sheriff, Nicola, additional, Blakey, Victoria, additional, Williams, Lesley-Anne, additional, Moore, Jonathan, additional, Stonehouse, Susanne, additional, Smith, Louise, additional, Davidson, Rose K., additional, Bedford, Luke, additional, Coupland, Lindsay, additional, Wright, Victoria, additional, Chappell, Joseph G., additional, Tsoleridis, Theocharis, additional, Ball, Jonathan, additional, Khakh, Manjinder, additional, Fleming, Vicki M., additional, Lister, Michelle M., additional, Howson-Wells, Hannah C., additional, Berry, Louise, additional, Boswell, Tim, additional, Joseph, Amelia, additional, Willingham, Iona, additional, Duckworth, Nichola, additional, Walsh, Sarah, additional, Wise, Emma, additional, Moore, Nathan, additional, Mori, Matilde, additional, Cortes, Nick, additional, Kidd, Stephen, additional, Williams, Rebecca, additional, Gifford, Laura, additional, Bicknell, Kelly, additional, Wyllie, Sarah, additional, Lloyd, Allyson, additional, Impey, Robert, additional, Malone, Cassandra S., additional, Cogger, Benjamin J., additional, Levene, Nick, additional, Monaghan, Lynn, additional, Keeley, Alexander J., additional, Partridge, David G., additional, Raza, Mohammad, additional, Evans, Cariad, additional, Johnson, Kate, additional, Betteridge, Emma, additional, Farr, Ben W., additional, Goodwin, Scott, additional, Quail, Michael A., additional, Scott, Carol, additional, Shirley, Lesley, additional, Thurston, Scott A.J., additional, Rajan, Diana, additional, Bronner, Iraad F., additional, Aigrain, Louise, additional, Redshaw, Nicholas M., additional, Lensing, Stefanie V., additional, McCarthy, Shane, additional, Makunin, Alex, additional, Balcazar, Carlos E., additional, Gallagher, Michael D., additional, Williamson, Kathleen A., additional, Stanton, Thomas D., additional, Michelsen, Michelle L., additional, Warwick-Dugdale, Joanna, additional, Manley, Robin, additional, Farbos, Audrey, additional, Harrison, James W., additional, Sambles, Christine M., additional, Studholme, David J., additional, Lackenby, Angie, additional, Mbisa, Tamyo, additional, Platt, Steven, additional, Miah, Shahjahan, additional, Bibby, David, additional, Manso, Carmen, additional, Hubb, Jonathan, additional, Dabrera, Gavin, additional, Ramsay, Mary, additional, Bradshaw, Daniel, additional, Schaefer, Ulf, additional, Groves, Natalie, additional, Gallagher, Eileen, additional, Lee, David, additional, Williams, David, additional, Ellaby, Nicholas, additional, Hartman, Hassan, additional, Manesis, Nikos, additional, Patel, Vineet, additional, Ledesma, Juan, additional, Twohig, Katherine A., additional, Allara, Elias, additional, Pearson, Clare, additional, Cheng, Jeffrey K.J., additional, Bridgewater, Hannah E., additional, Frost, Lucy R., additional, Taylor-Joyce, Grace, additional, Brown, Paul E., additional, Tong, Lily, additional, Broos, Alice, additional, Mair, Daniel, additional, Nichols, Jenna, additional, Carmichael, Stephen N., additional, Smollett, Katherine L., additional, Nomikou, Kyriaki, additional, Aranday-Cortes, Elihu, additional, Johnson, Natasha, additional, Nickbakhsh, Seema, additional, Vamos, Edith E., additional, Hughes, Margaret, additional, Rainbow, Lucille, additional, Eccles, Richard, additional, Nelson, Charlotte, additional, Whitehead, Mark, additional, Gregory, Richard, additional, Gemmell, Matthew, additional, Wierzbicki, Claudia, additional, Webster, Hermione J., additional, Fisher, Chloe L., additional, Signell, Adrian W., additional, Betancor, Gilberto, additional, Wilson, Harry D., additional, Nebbia, Gaia, additional, Flaviani, Flavia, additional, Cerda, Alberto C., additional, Merrill, Tammy V., additional, Wilson, Rebekah E., additional, Cotic, Marius, additional, Bayzid, Nadua, additional, Thompson, Thomas, additional, Acheson, Erwan, additional, Rushton, Steven, additional, O’Brien, Sarah, additional, Baker, David J., additional, Rudder, Steven, additional, Aydin, Alp, additional, Sang, Fei, additional, Debebe, Johnny, additional, Francois, Sarah, additional, Vasylyeva, Tetyana I., additional, Zamudio, Marina Escalera, additional, Gutierrez, Bernardo, additional, Marchbank, Angela, additional, Maksimovic, Joshua, additional, Spellman, Karla, additional, McCluggage, Kathryn, additional, Morgan, Mari, additional, Beer, Robert, additional, Afifi, Safiah, additional, Workman, Trudy, additional, Fuller, William, additional, Bresner, Catherine, additional, Angyal, Adrienn, additional, Green, Luke R., additional, Parsons, Paul J., additional, Tucker, Rachel M., additional, Brown, Rebecca, additional, Whiteley, Max, additional, Bonfield, James, additional, Puethe, Christoph, additional, Whitwham, Andrew, additional, Liddle, Jennifier, additional, Rowe, Will, additional, Siveroni, Igor, additional, Le-Viet, Thanh, additional, Gaskin, Amy, additional, Johnson, Rob, additional, Abnizova, Irina, additional, Ali, Mozam, additional, Allen, Laura, additional, Anderson, Ralph, additional, Ariani, Cristina, additional, Austin-Guest, Siobhan, additional, Bala, Sendu, additional, Barrett, Jeffrey, additional, Bassett, Andrew, additional, Battleday, Kristina, additional, Beal, James, additional, Beale, Mathew, additional, Bellany, Sam, additional, Bellerby, Tristram, additional, Bellis, Katie, additional, Berger, Duncan, additional, Berriman, Matt, additional, Bevan, Paul, additional, Binley, Simon, additional, Bishop, Jason, additional, Blackburn, Kirsty, additional, Boughton, Nick, additional, Bowker, Sam, additional, Brendler-Spaeth, Timothy, additional, Bronner, Iraad, additional, Brooklyn, Tanya, additional, Buddenborg, Sarah Kay, additional, Bush, Robert, additional, Caetano, Catarina, additional, Cagan, Alex, additional, Carter, Nicola, additional, Cartwright, Joanna, additional, Monteiro, Tiago Carvalho, additional, Chapman, Liz, additional, Chillingworth, Tracey-Jane, additional, Clapham, Peter, additional, Clark, Richard, additional, Clarke, Adrian, additional, Clarke, Catriona, additional, Cole, Daryl, additional, Cook, Elizabeth, additional, Coppola, Maria, additional, Cornell, Linda, additional, Cornwell, Clare, additional, Corton, Craig, additional, Crackett, Abby, additional, Cranage, Alison, additional, Craven, Harriet, additional, Craw, Sarah, additional, Crawford, Mark, additional, Cutts, Tim, additional, Dabrowska, Monika, additional, Davies, Matt, additional, Dawson, Joseph, additional, Day, Callum, additional, Densem, Aiden, additional, Dibling, Thomas, additional, Dockree, Cat, additional, Dodd, David, additional, Dogga, Sunil, additional, Dorman, Matthew, additional, Dougan, Gordon, additional, Dougherty, Martin, additional, Dove, Alexander, additional, Drummond, Lucy, additional, Dudek, Monika, additional, Durrant, Laura, additional, Easthope, Elizabeth, additional, Eckert, Sabine, additional, Ellis, Pete, additional, Farr, Ben, additional, Fenton, Michael, additional, Ferrero, Marcella, additional, Flack, Neil, additional, Fordham, Howerd, additional, Forsythe, Grace, additional, Francis, Matt, additional, Fraser, Audrey, additional, Freeman, Adam, additional, Galvin, Anastasia, additional, Garcia-Casado, Maria, additional, Gedny, Alex, additional, Girgis, Sophia, additional, Glover, James, additional, Gould, Oliver, additional, Gray, Andy, additional, Gray, Emma, additional, Griffiths, Coline, additional, Gu, Yong, additional, Guerin, Florence, additional, Hamilton, Will, additional, Hanks, Hannah, additional, Harrison, Ewan, additional, Harrott, Alexandria, additional, Harry, Edward, additional, Harvison, Julia, additional, Heath, Paul, additional, Hernandez-Koutoucheva, Anastasia, additional, Hobbs, Rhiannon, additional, Holland, Dave, additional, Holmes, Sarah, additional, Hornett, Gary, additional, Hough, Nicholas, additional, Huckle, Liz, additional, Hughes-Hallet, Lena, additional, Hunter, Adam, additional, Inglis, Stephen, additional, Iqbal, Sameena, additional, Jackson, Adam, additional, Jackson, David, additional, Verdejo, Carlos Jimenez, additional, Jones, Matthew, additional, Kallepally, Kalyan, additional, Kay, Keely, additional, Keatley, Jon, additional, Keith, Alan, additional, King, Alison, additional, Kitchin, Lucy, additional, Kleanthous, Matt, additional, Klimekova, Martina, additional, Korlevic, Petra, additional, Krasheninnkova, Ksenia, additional, Lane, Greg, additional, Langford, Cordelia, additional, Laverack, Adam, additional, Law, Katharine, additional, Lensing, Stefanie, additional, Lewis-Wade, Amanah, additional, Liddle, Jennifer, additional, Lin, Quan, additional, Lindsay, Sarah, additional, Linsdell, Sally, additional, Long, Rhona, 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additional, Patel, Gaurang, additional, Payne, Maggie, additional, Peacock, Sharon, additional, Petersen, Arabella, additional, Plowman, Deborah, additional, Preston, Tom, additional, Quail, Michael, additional, Rance, Richard, additional, Rawlings, Suzannah, additional, Redshaw, Nicholas, additional, Reynolds, Joe, additional, Reynolds, Mark, additional, Rice, Simon, additional, Richardson, Matt, additional, Roberts, Connor, additional, Robinson, Katrina, additional, Robinson, Melanie, additional, Robinson, David, additional, Rogers, Hazel, additional, Rojo, Eduardo Martin, additional, Roopra, Daljit, additional, Rose, Mark, additional, Rudd, Luke, additional, Sadri, Ramin, additional, Salmon, Nicholas, additional, Saul, David, additional, Schwach, Frank, additional, Seekings, Phil, additional, Simms, Alison, additional, Sinnott, Matt, additional, Sivadasan, Shanthi, additional, Siwek, Bart, additional, Sizer, Dale, additional, Skeldon, Kenneth, additional, Skelton, Jason, additional, Slater-Tunstill, Joanna, additional, Sloper, Lisa, additional, Smerdon, Nathalie, additional, Smith, Chris, additional, Smith, Christen, additional, Smith, James, additional, Smith, Katie, additional, Smith, Michelle, additional, Smith, Sean, additional, Smith, Tina, additional, Sneade, Leighton, additional, Soria, Carmen Diaz, additional, Sousa, Catarina, additional, Souster, Emily, additional, Sparkes, Andrew, additional, Spencer-Chapman, Michael, additional, Squares, Janet, additional, Stanley, Robert, additional, Steed, Claire, additional, Stickland, Tim, additional, Still, Ian, additional, Stratton, Mike, additional, Strickland, Michelle, additional, Swann, Allen, additional, Swiatkowska, Agnieszka, additional, Sycamore, Neil, additional, Swift, Emma, additional, Symons, Edward, additional, Szluha, Suzanne, additional, Taluy, Emma, additional, Tao, Nunu, additional, Taylor, Katy, additional, Taylor, Sam, additional, Thompson, Stacey, additional, Thompson, Mark, additional, Thomson, Mark, additional, Thomson, Nicholas, additional, Thurston, Scott, additional, Toombs, Dee, additional, Topping, Benjamin, additional, Tovar-Corona, Jaime, additional, Ungureanu, Daniel, additional, Uphill, James, additional, Urbanova, Jana, additional, Van, Philip Jansen, additional, Vancollie, Valerie, additional, Voak, Paul, additional, Walker, Danielle, additional, Walker, Matthew, additional, Waller, Matt, additional, Ward, Gary, additional, Weatherhogg, Charlie, additional, Webb, Niki, additional, Wells, Alan, additional, Wells, Eloise, additional, Westwood, Luke, additional, Whipp, Theo, additional, Whiteley, Thomas, additional, Whitton, Georgia, additional, Widaa, Sara, additional, Williams, Mia, additional, Wilson, Mark, additional, and Wright, Sean, additional

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2021
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183. Effects of a modified muscle sparing posterior technique in hip hemiarthroplasty for displaced intracapsular fractures on postoperative function compared to a standard lateral approach (HemiSPAIRE): protocol for a randomised controlled trial

Author

Price, Anna, primary, Ball, Susan, additional, Rhodes, Shelley, additional, Wickins, Robert, additional, Gordon, Elizabeth, additional, Aylward, Alex, additional, Cockcroft, Emma, additional, Morgan-Trimmer, Sarah, additional, Powell, Roy, additional, Timperley, John, additional, and Charity, John, additional

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2021
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184. Teachers' views on the acceptability and implementation of the Incredible Years® Teacher Classroom Management programme in English (UK) primary schools from the STARS trial.

Author

Allen, Kate, Hansford, Lorraine, Hayes, Rachel, Longdon, Bryony, Allwood, Matthew, Price, Anna, Byford, Sarah, Norwich, Brahm, and Ford, Tamsin

Subjects
CLASSROOM management, BEHAVIOR disorders in children, PRIMARY education, PRIMARY schools
Abstract

Background: The Incredible Years® (IY) Teacher Classroom Management (TCM) programme may reduce disruptive behaviour in the classroom and improve child and teacher mental health; however, few studies have considered how acceptable TCM is to teachers or what facilitators and barriers there are to its implementation. Aims: In this paper we examine the acceptability of the full 6‐day TCM programme and teachers' perceived barriers and facilitators to implementation in the English (UK) primary school context. Sample: Forty‐four English (UK) primary school teachers who attended the TCM programme as part of the STARS trial. Methods: We completed focus groups and telephone interviews with participating teachers 2 months after they completed the TCM programme. Thematic analysis was used to examine the data, and a framework approach was applied to organize and summarize themes. Results: Teachers liked the structure of the course, the peer group learning environment, delivery methods, and the opportunity to reflect outside the classroom on their practice. They reported that the video clips used lacked cultural relevance and highlighted the importance of group leadership style. Perceived facilitators to implementation included an understanding of the theory underpinning TCM and adaptability of the TCM strategies. Barriers included perceived gaps in the course content in relation to challenging behaviour, applying strategies with older children and the school context within which teachers were working. Conclusion: Our findings suggest high levels of acceptability to TCM overall, but also highlight the need for a whole school approach to combat potential barriers to implementation. [ABSTRACT FROM AUTHOR]

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2022
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185. Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

Author

Graham, Mark S, primary, Sudre, Carole H, additional, May, Anna, additional, Antonelli, Michela, additional, Murray, Benjamin, additional, Varsavsky, Thomas, additional, Kläser, Kerstin, additional, Canas, Liane S, additional, Molteni, Erika, additional, Modat, Marc, additional, Drew, David A, additional, Nguyen, Long H, additional, Polidori, Lorenzo, additional, Selvachandran, Somesh, additional, Hu, Christina, additional, Capdevila, Joan, additional, Hammers, Alexander, additional, Chan, Andrew T, additional, Wolf, Jonathan, additional, Spector, Tim D, additional, Steves, Claire J, additional, Ourselin, Sebastien, additional, Koshy, Cherian, additional, Ash, Amy, additional, Wise, Emma, additional, Moore, Nathan, additional, Mori, Matilde, additional, Cortes, Nick, additional, Lynch, Jessica, additional, Kidd, Stephen, additional, Fairley, Derek J, additional, Curran, Tanya, additional, McKenna, James P, additional, Adams, Helen, additional, Fraser, Christophe, additional, Golubchik, Tanya, additional, Bonsall, David, additional, Hassan-Ibrahim, Mohammed O, additional, Malone, Cassandra S, additional, Cogger, Benjamin J, additional, Wantoch, Michelle, additional, Reynolds, Nicola, additional, Warne, Ben, additional, Maksimovic, Joshua, additional, Spellman, Karla, additional, McCluggage, Kathryn, additional, John, Michaela, additional, Beer, Robert, additional, Afifi, Safiah, additional, Morgan, Sian, additional, Marchbank, Angela, additional, Price, Anna, additional, Kitchen, Christine, additional, Gulliver, Huw, additional, Merrick, Ian, additional, Southgate, Joel, additional, Guest, Martyn, additional, Munn, Robert, additional, Workman, Trudy, additional, Connor, Thomas R, additional, Fuller, William, additional, Bresner, Catherine, additional, Snell, Luke B, additional, Patel, Amita, additional, Charalampous, Themoula, additional, Nebbia, Gaia, additional, Batra, Rahul, additional, Edgeworth, Jonathan, additional, Robson, Samuel C, additional, Beckett, Angela H, additional, Aanensen, David M, additional, Underwood, Anthony P, additional, Yeats, Corin A, additional, Abudahab, Khalil, additional, Taylor, Ben EW, additional, Menegazzo, Mirko, additional, Clark, Gemma, additional, Smith, Wendy, additional, Khakh, Manjinder, additional, Fleming, Vicki M, additional, Lister, Michelle M, additional, Howson-Wells, Hannah C, additional, Berry, Louise, additional, Boswell, Tim, additional, Joseph, Amelia, additional, Willingham, Iona, additional, Jones, Carl, additional, Holmes, Christopher, additional, Bird, Paul, additional, Helmer, Thomas, additional, Fallon, Karlie, additional, Tang, Julian, additional, Raviprakash, Veena, additional, Campbell, Sharon, additional, Sheriff, Nicola, additional, Blakey, Victoria, additional, Williams, Lesley-Anne, additional, Loose, Matthew W, additional, Holmes, Nadine, additional, Moore, Christopher, additional, Carlile, Matthew, additional, Wright, Victoria, additional, Sang, Fei, additional, Debebe, Johnny, additional, Coll, Francesc, additional, Signell, Adrian W, additional, Betancor, Gilberto, additional, Wilson, Harry D, additional, Eldirdiri, Sahar, additional, Kenyon, Anita, additional, Davis, Thomas, additional, Pybus, Oliver G, additional, du Plessis, Louis, additional, Zarebski, Alex E, additional, Raghwani, Jayna, additional, Kraemer, Moritz UG, additional, Francois, Sarah, additional, Attwood, Stephen W, additional, Vasylyeva, Tetyana I, additional, Escalera Zamudio, Marina, additional, Gutierrez, Bernardo, additional, Torok, M. Estee, additional, Hamilton, William L, additional, Goodfellow, Ian G, additional, Hall, Grant, additional, Jahun, Aminu S, additional, Chaudhry, Yasmin, additional, Hosmillo, Myra, additional, Pinckert, Malte L, additional, Georgana, Iliana, additional, Moses, Samuel, additional, Lowe, Hannah, additional, Bedford, Luke, additional, Moore, Jonathan, additional, Stonehouse, Susanne, additional, Fisher, Chloe L, additional, Awan, Ali R, additional, BoYes, John, additional, Breuer, Judith, additional, Harris, Kathryn Ann, additional, Brown, Julianne Rose, additional, Shah, Divya, additional, Atkinson, Laura, additional, Lee, Jack CD, additional, Storey, Nathaniel, additional, Flaviani, Flavia, additional, Alcolea-Medina, Adela, additional, Williams, Rebecca, additional, Vernet, Gabrielle, additional, Chapman, Michael R, additional, Levett, Lisa J, additional, Heaney, Judith, additional, Chatterton, Wendy, additional, Pusok, Monika, additional, Xu-McCrae, Li, additional, Smith, Darren L, additional, Bashton, Matthew, additional, Young, Gregory R, additional, Holmes, Alison, additional, Randell, Paul Anthony, additional, Cox, Alison, additional, Madona, Pinglawathee, additional, Bolt, Frances, additional, Price, James, additional, Mookerjee, Siddharth, additional, Ragonnet-Cronin, Manon, additional, Nascimento, Fabricia F., additional, Jorgensen, David, additional, Siveroni, Igor, additional, Johnson, Rob, additional, Boyd, Olivia, additional, Geidelberg, Lily, additional, Volz, Erik M, additional, Rowan, Aileen, additional, Taylor, Graham P, additional, Smollett, Katherine L, additional, Loman, Nicholas J, additional, Quick, Joshua, additional, McMurray, Claire, additional, Stockton, Joanne, additional, Nicholls, Sam, additional, Rowe, Will, additional, Poplawski, Radoslaw, additional, McNally, Alan, additional, Martinez Nunez, Rocio T, additional, Mason, Jenifer, additional, Robinson, Trevor I, additional, O'Toole, Elaine, additional, Watts, Joanne, additional, Breen, Cassie, additional, Cowell, Angela, additional, Sluga, Graciela, additional, Machin, Nicholas W, additional, Ahmad, Shazaad S Y, additional, George, Ryan P, additional, Halstead, Fenella, additional, Sivaprakasam, Venkat, additional, Hogsden, Wendy, additional, Illingworth, Chris J, additional, Jackson, Chris, additional, Thomson, Emma C, additional, Shepherd, James G, additional, Asamaphan, Patawee, additional, Niebel, Marc O, additional, Li, Kathy K, additional, Shah, Rajiv N, additional, Jesudason, Natasha G, additional, Tong, Lily, additional, Broos, Alice, additional, Mair, Daniel, additional, Nichols, Jenna, additional, Carmichael, Stephen N, additional, Nomikou, Kyriaki, additional, Aranday-Cortes, Elihu, additional, Johnson, Natasha, additional, Starinskij, Igor, additional, da Silva Filipe, Ana, additional, Robertson, David L, additional, Orton, Richard J, additional, Hughes, Joseph, additional, Vattipally, Sreenu, additional, Singer, Joshua B, additional, Nickbakhsh, Seema, additional, Hale, Antony D, additional, Macfarlane-Smith, Louissa R, additional, Harper, Katherine L, additional, Carden, Holli, additional, Taha, Yusri, additional, Payne, Brendan AI, additional, Burton-Fanning, Shirelle, additional, Waugh, Sheila, additional, Collins, Jennifer, additional, Eltringham, Gary, additional, Rushton, Steven, additional, O'Brien, Sarah, additional, Bradley, Amanda, additional, Maclean, Alasdair, additional, Mollett, Guy, additional, Blacow, Rachel, additional, Templeton, Kate E, additional, McHugh, Martin P, additional, Dewar, Rebecca, additional, Wastenge, Elizabeth, additional, Dervisevic, Samir, additional, Stanley, Rachael, additional, Meader, Emma J, additional, Coupland, Lindsay, additional, Smith, Louise, additional, Graham, Clive, additional, Barton, Edward, additional, Padgett, Debra, additional, Scott, Garren, additional, Swindells, Emma, additional, Greenaway, Jane, additional, Nelson, Andrew, additional, McCann, Clare M, additional, Yew, Wen C, additional, Andersson, Monique, additional, Peto, Timothy, additional, Justice, Anita, additional, Eyre, David, additional, Crook, Derrick, additional, Sloan, Tim J, additional, Duckworth, Nichola, additional, Walsh, Sarah, additional, Chauhan, Anoop J, additional, Glaysher, Sharon, additional, Bicknell, Kelly, additional, Wyllie, Sarah, additional, Elliott, Scott, additional, Lloyd, Allyson, additional, Impey, Robert, additional, Levene, Nick, additional, Monaghan, Lynn, additional, Bradley, Declan T, additional, Wyatt, Tim, additional, Allara, Elias, additional, Pearson, Clare, additional, Osman, Husam, additional, Bosworth, Andrew, additional, Robinson, Esther, additional, Muir, Peter, additional, Vipond, Ian B, additional, Hopes, Richard, additional, Pymont, Hannah M, additional, Hutchings, Stephanie, additional, Curran, Martin D, additional, Parmar, Surendra, additional, Lackenby, Angie, additional, Mbisa, Tamyo, additional, Platt, Steven, additional, Miah, Shahjahan, additional, Bibby, David, additional, Manso, Carmen, additional, Hubb, Jonathan, additional, Chand, Meera, additional, Dabrera, Gavin, additional, Ramsay, Mary, additional, Bradshaw, Daniel, additional, Thornton, Alicia, additional, Myers, Richard, additional, Schaefer, Ulf, additional, Groves, Natalie, additional, Gallagher, Eileen, additional, Lee, David, additional, Williams, David, additional, Ellaby, Nicholas, additional, Harrison, Ian, additional, Hartman, Hassan, additional, Manesis, Nikos, additional, Patel, Vineet, additional, Bishop, Chloe, additional, Chalker, Vicki, additional, Ledesma, Juan, additional, Twohig, Katherine A, additional, Holden, Matthew T.G., additional, Shaaban, Sharif, additional, Birchley, Alec, additional, Adams, Alexander, additional, Davies, Alisha, additional, Gaskin, Amy, additional, Plimmer, Amy, additional, Gatica-Wilcox, Bree, additional, McKerr, Caoimhe, additional, Moore, Catherine, additional, Williams, Chris, additional, Heyburn, David, additional, De Lacy, Elen, additional, Hilvers, Ember, additional, Downing, Fatima, additional, Shankar, Giri, additional, Jones, Hannah, additional, Asad, Hibo, additional, Coombes, Jason, additional, Watkins, Joanne, additional, Evans, Johnathan M, additional, Fina, Laia, additional, Gifford, Laura, additional, Gilbert, Lauren, additional, Graham, Lee, additional, Perry, Malorie, additional, Morgan, Mari, additional, Bull, Matthew, additional, Cronin, Michelle, additional, Pacchiarini, Nicole, additional, Craine, Noel, additional, Jones, Rachel, additional, Howe, Robin, additional, Corden, Sally, additional, Rey, Sara, additional, Kumziene-SummerhaYes, Sara, additional, Taylor, Sarah, additional, Cottrell, Simon, additional, Jones, Sophie, additional, Edwards, Sue, additional, O'Grady, Justin, additional, Page, Andrew J, additional, Mather, Alison E, additional, Baker, David J, additional, Rudder, Steven, additional, Aydin, Alp, additional, Kay, Gemma L, additional, Trotter, Alexander J, additional, Alikhan, Nabil-Fareed, additional, de Oliveira Martins, Leonardo, additional, Le-Viet, Thanh, additional, Meadows, Lizzie, additional, Casey, Anna, additional, Ratcliffe, Liz, additional, Simpson, David A, additional, Molnar, Zoltan, additional, Thompson, Thomas, additional, Acheson, Erwan, additional, Masoli, Jane AH, additional, Knight, Bridget A, additional, Ellard, Sian, additional, Auckland, Cressida, additional, Jones, Christopher R, additional, Mahungu, Tabitha W, additional, Irish-Tavares, Dianne, additional, Haque, Tanzina, additional, Hart, Jennifer, additional, Witele, Eric, additional, Fenton, Melisa Louise, additional, Dadrah, Ashok, additional, Symmonds, Amanda, additional, Saluja, Tranprit, additional, Bourgeois, Yann, additional, Scarlett, Garry P, additional, Loveson, Katie F, additional, Goudarzi, Salman, additional, Fearn, Christopher, additional, Cook, Kate, additional, Dent, Hannah, additional, Paul, Hannah, additional, Partridge, David G, additional, Raza, Mohammad, additional, Evans, Cariad, additional, Johnson, Kate, additional, Liggett, Steven, additional, Baker, Paul, additional, Bonner, Stephen, additional, Essex, Sarah, additional, Lyons, Ronan A, additional, Saeed, Kordo, additional, Mahanama, Adhyana I.K, additional, Samaraweera, Buddhini, additional, Silveira, Siona, additional, Pelosi, Emanuela, additional, Wilson-Davies, Eleri, additional, Williams, Rachel J, additional, Kristiansen, Mark, additional, Roy, Sunando, additional, Williams, Charlotte A, additional, Cotic, Marius, additional, Bayzid, Nadua, additional, Westhorpe, Adam P, additional, Hartley, John A, additional, Jannoo, Riaz, additional, Lowe, Helen L, additional, Karamani, Angeliki, additional, Ensell, Leah, additional, Prieto, Jacqui A, additional, Jeremiah, Sarah, additional, Grammatopoulos, Dimitris, additional, Pandey, Sarojini, additional, Berry, Lisa, additional, Jones, Katie, additional, Richter, Alex, additional, Beggs, Andrew, additional, Best, Angus, additional, Percival, Benita, additional, Mirza, Jeremy, additional, Megram, Oliver, additional, Mayhew, Megan, additional, Crawford, Liam, additional, Ashcroft, Fiona, additional, Moles-Garcia, Emma, additional, Cumley, Nicola, additional, Smith, Colin P, additional, Bucca, Giselda, additional, Hesketh, Andrew R, additional, Blane, Beth, additional, Girgis, Sophia T, additional, Leek, Danielle, additional, Sridhar, Sushmita, additional, Forrest, Sally, additional, Cormie, Claire, additional, Gill, Harmeet K, additional, Dias, Joana, additional, Higginson, Ellen E, additional, Maes, Mailis, additional, Young, Jamie, additional, Kermack, Leanne M, additional, Gupta, Ravi Kumar, additional, Ludden, Catherine, additional, Peacock, Sharon J, additional, Palmer, Sophie, additional, Churcher, Carol M, additional, Hadjirin, Nazreen F, additional, Carabelli, Alessandro M, additional, Brooks, Ellena, additional, Smith, Kim S, additional, Galai, Katerina, additional, McManus, Georgina M, additional, Ruis, Chris, additional, Davidson, Rose K, additional, Rambaut, Andrew, additional, Williams, Thomas, additional, Balcazar, Carlos E, additional, Gallagher, Michael D, additional, O'Toole, Áine, additional, Rooke, Stefan, additional, Hill, Verity, additional, Williamson, Kathleen A, additional, Stanton, Thomas D, additional, Michell, Stephen L, additional, Bewshea, Claire M, additional, Temperton, Ben, additional, Michelsen, Michelle L, additional, Warwick-Dugdale, Joanna, additional, Manley, Robin, additional, Farbos, Audrey, additional, Harrison, James W, additional, Sambles, Christine M, additional, Studholme, David J, additional, Jeffries, Aaron R, additional, Darby, Alistair C, additional, Hiscox, Julian A, additional, Paterson, Steve, additional, Iturriza-Gomara, Miren, additional, Jackson, Kathryn A, additional, Lucaci, Anita O, additional, Vamos, Edith E, additional, Hughes, Margaret, additional, Rainbow, Lucille, additional, Eccles, Richard, additional, Nelson, Charlotte, additional, Whitehead, Mark, additional, Turtle, Lance, additional, Haldenby, Sam T, additional, Gregory, Richard, additional, Gemmell, Matthew, additional, Wierzbicki, Claudia, additional, Webster, Hermione J, additional, de Silva, Thushan I, additional, Smith, Nikki, additional, Angyal, Adrienn, additional, Lindsey, Benjamin B, additional, Groves, Danielle C, additional, Green, Luke R, additional, Wang, Dennis, additional, Freeman, Timothy M, additional, Parker, Matthew D, additional, Keeley, Alexander J, additional, Parsons, Paul J, additional, Tucker, Rachel M, additional, Brown, Rebecca, additional, Wyles, Matthew, additional, Whiteley, Max, additional, Zhang, Peijun, additional, Gallis, Marta, additional, Louka, Stavroula F, additional, Constantinidou, Chrystala, additional, Unnikrishnan, Meera, additional, Ott, Sascha, additional, Cheng, Jeffrey K.J., additional, Bridgewater, Hannah E., additional, Frost, Lucy R., additional, Taylor-Joyce, Grace, additional, Stark, Richard, additional, Baxter, Laura, additional, Alam, Mohammad T., additional, Brown, Paul E, additional, Aggarwal, Dinesh, additional, Cerda, Alberto C, additional, Merrill, Tammy V, additional, Wilson, Rebekah E, additional, McClure, Patrick C, additional, Chappell, Joseph G, additional, Tsoleridis, Theocharis, additional, Ball, Jonathan, additional, Buck, David, additional, Todd, John A, additional, Green, Angie, additional, Trebes, Amy, additional, MacIntyre-Cockett, George, additional, de Cesare, Mariateresa, additional, Alderton, Alex, additional, Amato, Roberto, additional, Ariani, Cristina V, additional, Beale, Mathew A, additional, Beaver, Charlotte, additional, Bellis, Katherine L, additional, Betteridge, Emma, additional, Bonfield, James, additional, Danesh, John, additional, Dorman, Matthew J, additional, Drury, Eleanor, additional, Farr, Ben W, additional, Foulser, Luke, additional, Goncalves, Sonia, additional, Goodwin, Scott, additional, Gourtovaia, Marina, additional, Harrison, Ewan M, additional, Jackson, David K, additional, Jamrozy, Dorota, additional, Johnston, Ian, additional, Kane, Leanne, additional, Kay, Sally, additional, Keatley, Jon-Paul, additional, Kwiatkowski, Dominic, additional, Langford, Cordelia F, additional, Lawniczak, Mara, additional, Letchford, Laura, additional, Livett, Rich, additional, Lo, Stephanie, additional, Martincorena, Inigo, additional, McGuigan, Samantha, additional, Nelson, Rachel, additional, Palmer, Steve, additional, Park, Naomi R, additional, Patel, Minal, additional, Prestwood, Liam, additional, Puethe, Christoph, additional, Quail, Michael A, additional, Rajatileka, Shavanthi, additional, Scott, Carol, additional, Shirley, Lesley, additional, Sillitoe, John, additional, Spencer Chapman, Michael H, additional, Thurston, Scott AJ, additional, Tonkin-Hill, Gerry, additional, Weldon, Danni, additional, Rajan, Diana, additional, Bronner, Iraad F, additional, Aigrain, Louise, additional, Redshaw, Nicholas M, additional, Lensing, Stefanie V, additional, Davies, Robert, additional, Whitwham, Andrew, additional, Liddle, Jennifier, additional, Lewis, Kevin, additional, Tovar-Corona, Jaime M, additional, Leonard, Steven, additional, Durham, Jillian, additional, Bassett, Andrew R, additional, McCarthy, Shane, additional, Moll, Robin J, additional, James, Keith, additional, Oliver, Karen, additional, Makunin, Alex, additional, Barrett, Jeff, additional, and Gunson, Rory N, additional

Published
2021
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186. Study protocol for the Healthier Wealthier Families (HWF) pilot randomised controlled trial: testing the feasibility of delivering financial counselling to families with young children who are identified as experiencing financial hardship by community-based nurses

Author

Price, Anna M H, primary, Zhu, Anna, additional, Nguyen, Huu N J, additional, Contreras-Suárez, Diana, additional, Schreurs, Natalie, additional, Burley, Jade, additional, Lawson, Kenny D, additional, Kelaher, Margaret, additional, Lingam, Raghu, additional, Grace, Rebekah, additional, Raman, Shanti, additional, Kemp, Lynn, additional, Woolfenden, Susan, additional, and Goldfeld, Sharon, additional

Published
2021
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187. Non-animal Methods in Science and Regulation: EURL ECVAM Status Report 2020

Author

ZUANG VALERIE, DURA ADELAIDE, ASTURIOL BOFILL DAVID, BATISTA LEITE SOFIA, BERGGREN ELISABET, BOPP STEPHANIE, CARPI DONATELLA, CASATI SILVIA, COECKE SANDRA, CORVI RAFFAELLA, DECEUNINCK PIERRE, FRANCO ANTONIO, GRIBALDO LAURA, HALDER MARIA ELISABETH, HOLLOWAY MARCELLE, KIENZLER AUDE, LANGEZAAL INGRID, MADIA FEDERICA, MILCAMPS ANNE, MUNN SHARON, PAINI ALICIA, PIERGIOVANNI MONICA, PISTOLLATO FRANCESCA, PRICE ANNA, PRIETO PERAITA MARIA DEL PILAR, VIEGAS BARROSO JOAO FILIPE, WITTWEHR CLEMENS, WORTH ANDREW, and WHELAN MAURICE

Abstract

The annual EURL ECVAM status report describes research, development and validation activities, as well as initiatives that promote the regulatory use and international adoption of non-animal methods and approaches and their dissemination in the regulatory and research arenas. EU policies and legislation call for innovative and more efficient ways of safety testing and chemical risk assessment that do not depend on animal testing. Advanced technologies such as computational models, in vitro methods and organ-on-chip devices are being developed, evaluated and integrated to translate mechanistic understanding of toxicity into safety testing strategies. The ultimate goal is to achieve better protection of human health and the environment while supporting EU innovation and industrial competitiveness, without the use of animals. The development and use of non-animal models and methods are also essential for advancing basic, applied and translational research. Education also plays an essential role in enabling a shift to non-animal methods through the introduction of the Three Rs (Replacement, Reduction and Refinement of animal use in science) into secondary school curricula and programmes of higher education., JRC.F.3-Chemicals Safety and Alternative Methods

Published
2020

188. Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

Author

Price, Anna M, Greenhall, George HB, Moody, William E, Steeds, Richard P, Mark, Patrick B, Edwards, Nicola C, Hayer, Manvir K, Pickup, Luke C, Radhakrishnan, Ashwin, Law, Jonathan P, Banerjee, Debasish, Campbell, Tunde, Tomson, Charles RV, Cockcroft, John R, Shrestha, Badri, Wilkinson, Ian B, Tomlinson, Laurie A, Ferro, Charles J, Townend, Jonathan N, and EARNEST investigators

Abstract

BACKGROUND AND OBJECTIVES: The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness and Central Hemodynamics (EARNEST) study was a multicenter, prospective, controlled study designed to investigate the associations of an isolated reduction in kidney function on BP and arterial hemodynamics. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective living kidney donors and healthy controls who fulfilled criteria for donation were recruited from centers with expertise in vascular research. Participants underwent office and ambulatory BP measurement, assessment of arterial stiffness, and biochemical tests at baseline and 12 months. RESULTS: A total of 469 participants were recruited, and 306 (168 donors and 138 controls) were followed up at 12 months. In the donor group, mean eGFR was 27 ml/min per 1.73 m2 lower than baseline at 12 months. Compared with baseline, at 12 months the mean within-group difference in ambulatory day systolic BP in donors was 0.1 mm Hg (95% confidence interval, -1.7 to 1.9) and 0.6 mm Hg (95% confidence interval, -0.7 to 2.0) in controls. The between-group difference was -0.5 mm Hg (95% confidence interval, -2.8 to 1.7; P=0.62). The mean within-group difference in pulse wave velocity in donors was 0.3 m/s (95% confidence interval, 0.1 to 0.4) and 0.2 m/s (95% confidence interval, -0.0 to 0.4) in controls. The between-group difference was 0.1 m/s (95% confidence interval, -0.2 to 0.3; P=0.49). CONCLUSIONS: Changes in ambulatory peripheral BP and pulse wave velocity in kidney donors at 12 months after nephrectomy were small and not different from controls. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT01769924 (https://clinicaltrials.gov/ct2/show/NCT01769924).

Published
2020

189. Additional file 3 of Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

Author

Pistollato, Francesca, Gyves, Emilio, Carpi, Donatella, Bopp, Stephanie, Nunes, Carolina, Worth, Andrew, and Bal-Price, Anna

Abstract

Additional file 3: Figure S7. Single chemicals and mixtures effects on synaptogenesis. HiPSC-derived NSCs were differentiated for 7 DIV, and then treated for either 3 days (A-C) or 14 days (D-F) with single chemicals (BPA, CPF, Lead, Methyl-Hg, PCB138 and VA) or three types of mixtures: (i) a mixture with the 3 similar MoA chemicals (‘3-Sim’), (ii) a mixture with the 3 dissimilar MoA chemicals (‘3-Diss’), and (iii) a mixture with all 6 chemicals (‘All’). Graphs show: (A, D) total PSD95 protein levels; (B, E) total SYP protein levels, and (C, F) the number or overlapping SYP and PSD95 spots at the levels of nerites (i.e., SYP/PSD95 co-localization, synapses). All samples were normalized to solvent control (0.1% DMSO, Ctr) at the respective time point. LOAEC-syn (red curves) and their serial dilutions (respectively black (1:2) and blue (1:4) curves) were tested as indicated in Table 3 (reporting concentrations tested for each individual chemical). Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S8. Single chemicals and mixtures effects on neurite outgrowth. HiPSC-derived NSCs were differentiated for 7 DIV, and then treated for either 3 days (A-D) or 14 days (E-G) with single chemicals (BPA, CPF, Lead, Methyl-Hg, PCB138 and VA) or three types of mixtures: (i) a mixture with the 3 similar MoA chemicals (‘3-Sim’), (ii) a mixture with the 3 dissimilar MoA chemicals (‘3-Diss’), and (iii) a mixture with all 6 chemicals (‘All’). Graphs show: (A, E) neurite length, (B, F) the number of branch points per neurite, (C, G) the number of neurites per neuron, and (D, H) the percentage of β-III-Tubulin+ cells. All samples were normalized to solvent control (0.1% DMSO, Ctr) at the respective time point. LOAEC-neu (red curves) and their serial dilutions (respectively black (1:2), blue (1:4) and light blue (1:8) curves) were tested as indicated in Table 3 (reporting concentrations tested for each individual chemical). Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S9. Effects of chlorpyrifos (CPF) and valproic acid (VA) withdrawal from mixtures on neurite outgrowth. HiPSC-derived NSCs were differentiated for 7 DIV, and then treated for 14 days with: (i) the ‘3-Sim’ mixture (BPA, Lead and CPF) and the same mixture without CPF, (ii) the ‘3-Dissim’ mixture (Methyl-Hg, PCB138 and VA) and the same mixture without VA, (iii) the ‘All’ mixture (BPA, CPF, Lead, Methyl-Hg, PCB138, and VA) and the same mixture excluding CPF and VA. (A) Representative pictures at 10x magnification (β-III-Tubulin, in red). (B-E) Graphs show neurite outgrowth after 14 day treatment with LOAEC/2-neu (black bars), and LOAEC/4-neu concentrations (blue bars). Graphs show total live (non-pyknotic) cell numbers (B, based on DAPI staining), neurite length (C), the number of branch points per neurite (D), and the number of neurites per neuron (E) analysed upon treatments with LOAEC/2-neu and LOAEC/4-neu concentrations as indicated in Table 3 (reporting concentrations tested for each individual chemical). Values were normalised to the corresponding complete mixtures, and data are represented as mean ± S.E.M. of 3 biological replicates. Statistical significance was assessed by unpaired t-test, comparing each differential mixture vs the original mixture (e.g., ‘3-Sim’ vs ‘3-Sim (−CPF)’). p

Published
2020
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191. EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2019)

Author

ZUANG VALERIE, DURA ADELAIDE, ASTURIOL BOFILL DAVID, BATISTA LEITE SOFIA, BERGGREN ELISABET, BERNASCONI CAMILLA, BOPP STEPHANIE, BOWE GERARD, CAMPIA IVANA, CARPI DONATELLA, CASATI SILVIA, COECKE SANDRA, COLE THOMAS, CORVI RAFFAELLA, DECEUNINCK PIERRE, FORTANER TORRENT SALVADOR, FRANCO ANTONIO, GRIBALDO LAURA, GRIGNARD ELISE, HALDER MARIA ELISABETH, HOLLOWAY MARCELLE, KIENZLER AUDE, MACKO PETER, MADIA FEDERICA, MILCAMPS ANNE, MORATH SIEGFRIED, MUNN SHARON, PAINI ALICIA, PALOSAARI TAINA, PISTOLLATO FRANCESCA, PRICE ANNA, PRIETO PERAITA MARIA DEL PILAR, SUND JUKKA, VIEGAS BARROSO JOAO FILIPE, WITTWEHR CLEMENS, WORTH ANDREW, and WHELAN MAURICE

Abstract

The European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) is an integral part of the European Commision's Joint Research Centre. The EURL ECVAM status report informs about research and development activities, test method submissions, validation and peer reviews, activities that promote the regulatory acceptance and international adoption of alternative methods and approaches and their dissemination. Replacement, reduction and refinement of animal testing (Three Rs) in basic, applied and translational research, as well as for regulatory purposes is anchored in EU legislation. Innovative technologies (e.g., computational models, in vitro methods, organ-on-chip devices) are developed, evaluated and integrated in assessment strategies for chemicals and products safety testing in order to preserve a high level of protection for human health and the environment. Important activities to promote the development and use of alternative methods and approaches are also pursued in the areas of basic and applied research as well as for education purposes., JRC.F.3-Chemicals Safety and Alternative Methods

Published
2020

192. Additional file 2 of Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

Author

Pistollato, Francesca, Gyves, Emilio Mendoza De, Carpi, Donatella, Bopp, Stephanie K., Nunes, Carolina, Worth, Andrew, and Bal-Price, Anna

Abstract

Additional file 2: Figure S1. Effects elicited by Bisphenol A (BPA); quantitative evaluation of immunocytochemistry using HCI (Cellomics platform). IMR90-derived NSCs were differentiated for 7 DIV and treated for either 3 or 14 days with three different concentrations of BPA (0.29 μM, IC20/100, white bars; 12.74 μM, IC5, grey bars; 28.96 μM, IC20, black bars) in comparison to solvent control (0.1% DMSO, Ctr) at the respective time point. Analysis of BPA effects on: (A) total (i.e., cell body and neurites) and in neurites only expression of SYP (pre-synaptic) and PSD95 (post-synaptic proteins (MAP2 staining was used as a marker of neurites), and the number of overlapping SYP/PSD95 spots (synapses) in the neurites; (B) neurite length and branch points per neurite; (C) total BDNF protein levels and BDNF expression ratio, comparing neurite to cell body. Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S2. Effects elicited by Chlorpyrifos (CPF); quantitative evaluation of immunocytochemistry using HCI (Cellomics platform). IMR90-derived NSCs were differentiated for 7 DIV and treated for either 3 or 14 days with three different concentrations of CPF (0.37 μM, IC20/100, white bars; 21.01 μM, IC5, grey bars; 37.10 μM, IC20, black bars) in comparison to solvent control (0.1% DMSO, Ctr) at the respective time point. Analysis of CPF effects on: (A) total (i.e., cell body and neurites) and in neurites only expression of SYP (pre-synaptic) and PSD95 (post-synaptic proteins (MAP2 staining was used as a marker of neurites), and the number of overlapping SYP/PSD95 spots (synapses) in the neurites; (B) neurite length and branch points per neurite; (C) total BDNF protein levels and BDNF expression ratio, comparing neurite to cell body. Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S3. Effects elicited by Lead(II) chloride (Lead); quantitative evaluation of immunocytochemistry using HCI (Cellomics platform). IMR90-derived NSCs were differentiated for 7 DIV and treated for either 3 or 14 days with three different concentrations of Lead (0.0073 μM, IC20/100, white bars; 0.17 μM, IC5, grey bars; 0.73 μM, IC20, black bars) in comparison to solvent control (0.1% DMSO, Ctr) at the respective time point. Analysis of Lead effects on: (A) total (i.e., cell body and neurites) and in neurites only expression of SYP (pre-synaptic) and PSD95 (post-synaptic proteins (MAP2 staining was used as a marker of neurites), and the number of overlapping SYP/PSD95 spots (synapses) in the neurites; (B) neurite length and branch points per neurite; (C) total BDNF protein levels and BDNF expression ratio, comparing neurite to cell body. Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S4. Effects elicited by Methylmercury(II) chloride (Methyl-Hg); quantitative evaluation of immunocytochemistry using HCI (Cellomics platform). IMR90-derived NSCs were differentiated for 7 DIV and treated for either 3 or 14 days with three different concentrations of Methyl-Hg (0.0013 μM, IC20/100, white bars; 0.05 μM, IC5, grey bars; 0.13 μM, IC20, black bars) in comparison to solvent control (0.1% DMSO, Ctr) at the respective time point. Analysis of Methyl-Hg effects on: (A) total (i.e., cell body and neurites) and in neurites only expression of SYP (pre-synaptic) and PSD95 (post-synaptic proteins (MAP2 staining was used as a marker of neurites), and the number of overlapping SYP/PSD95 spots (synapses) in the neurites; (B) neurite length and branch points per neurite; (C) total BDNF protein levels and BDNF expression ratio, comparing neurite to cell body. Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S5. Effects elicited by PCB138; quantitative evaluation of immunocytochemistry using HCI (Cellomics platform). IMR90-derived NSCs were differentiated for 7 DIV and treated for either 3 or 14 days with three different concentrations of PCB138 (0.0593 μM, IC20/100, white bars; 3.53 μM, IC5, grey bars; 5.93 μM, IC20, black bars) in comparison to solvent control (0.1% DMSO, Ctr) at the respective time point. Analysis of PCB138 effects on: (A) total (i.e., cell body and neurites) and in neurites only expression of SYP (pre-synaptic) and PSD95 (post-synaptic proteins (MAP2 staining was used as a marker of neurites), and the number of overlapping SYP/PSD95 spots (synapses) in the neurites; (B) neurite length and branch points per neurite; (C) total BDNF protein levels and BDNF expression ratio, comparing neurite to cell body. Data are represented as mean ± S.E.M. of 3–4 biological replicates. Figure S6. Effects elicited by Valproic acid (VA); quantitative evaluation of immunocytochemistry using HCI (Cellomics platform). IMR90-derived NSCs were differentiated for 7 DIV and treated for either 3 or 14 days with three different concentrations of VA (2.1 μM, IC20/100, white bars; 70 μM, IC5, grey bars; 210 μM, IC20, black bars) in comparison to solvent control (0.1% DMSO, Ctr) at the respective time point. Analysis of VA effects on: (A) total (i.e., cell body and neurites) and in neurites only expression of SYP (pre-synaptic) and PSD95 (post-synaptic proteins (MAP2 staining was used as a marker of neurites), and the number of overlapping SYP/PSD95 spots (synapses) in the neurites; (B) neurite length and branch points per neurite; (C) total BDNF protein levels and BDNF expression ratio, comparing neurite to cell body. Data are represented as mean ± S.E.M. of 3–4 biological replicates.

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2020
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193. Additional file 4 of Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

Author

Pistollato, Francesca, Gyves, Emilio Mendoza De, Carpi, Donatella, Bopp, Stephanie K., Nunes, Carolina, Worth, Andrew, and Bal-Price, Anna

Abstract

Additional file 4: Figure S10. Single chemical curves. Each panel represents the modeled response of single chemicals (i.e., A, BPA; B, CPF; C, Lead; D, Methyl-Hg; E, PCB138, and F, VA) for all the selected DNT endpoints. To calculate the single chemical dose response effects for all the selected DNT endpoints the following concentrations were tested: BPA (8.5, 12.7, 19.1, 28.7, 43.0, 60.2 μM), CPF (18.5, 21.2, 24.4, 28.1, 32.3, 37.1 μM), Lead (0.001, 0.007, 0.037, 0.18, 0.91, 1.27, 1.46, 1.68, 1.93, 2.22, 2.67 μM), Methyl-Hg (0.03, 0.05, 0.09, 0.16, 0.29, 0.33 μM), PCB138 (0.01, 0.06, 0.25, 1.05, 4.39, 9.41 μM), and VA (0.5, 2.1, 8.4, 33.6, 134.4, 537 μM). The effect was estimated according to seven different mathematical models (i.e., Hill, Power, Linear, Polynomial 2, Exponential 2, Exponential 3, Exponential 4, and Exponential 5) by using the BMDExpress.2 open access software (https://github.com/auerbachs/BMDExpress-2/wiki). The best-fitting curve across the range of concentration tested is represented in the figure as percentage of response compared to the solvent control (0.1% DMSO). Table S3. BMDs synaptogenesis. The table lists the best fitting model selected for the analysis of synaptogenesis performed by BMDExpress, according to the lowest Akaike information criterion and higher fit P value. The value of the calculated BMD5 for each chemical is also reported, including the respective BMDL and BMDU. Table S4. BMDs % neurons and neurite outgrowth. The table lists the best fitting models selected for the analysis of neuronal cell (β-III-tubulin+) percentage and neurite outgrowth-related parameters performed by BMDExpress, according to the lowest Akaike information criterion and higher fit P value. The value of the calculated BMD5 for each chemical is also reported, including the respective BMDL and BMDU. Table S5. BMDs BNDF levels. The table lists the best fitting models selected for the analysis of BDNF levels performed by BMDExpress, according to the lowest Akaike information criterion and higher fit P value. The value of the calculated BMD5 for each chemical is also reported, including the respective BMDL and BMDU.

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2020
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198. 20200227Supplemental – Supplemental material for HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair

Author

Tay, Ian J., Park, James J. H., Price, Anna L., Engelward, Bevin P., and Floyd, Scott R.

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, 20200227Supplemental for HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair by Ian J. Tay, James J. H. Park, Anna L. Price, Bevin P. Engelward and Scott R. Floyd in SLAS Discovery

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2020
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199. Additional file 1 of Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

Author

Pistollato, Francesca, Gyves, Emilio Mendoza De, Carpi, Donatella, Bopp, Stephanie K., Nunes, Carolina, Worth, Andrew, and Bal-Price, Anna

Abstract

Additional file 1: Table S1. Chemicals acting through similar MoA (alterations of BDNF levels): summary of their effects and mode of action (MoA) based on literature review, along with epidemiological studies describing chemical concentrations found in human biological samples. Table S2. Chemicals acting through dissimilar MoAs (not directly linked to alterations of BDNF levels): summary of their effects and mode of action (MoA) based on literature review, along with epidemiological studies describing chemical concentrations found in human biological samples.

Published
2020
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200. Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

Author

Coecke, Sandra, Goldberg, Alan M., Allen, Sandra, Buzanska, Leonora, Calamandrei, Gemma, Crofton, Kevin, Hareng, Lars, Hartung, Thomas, Knaut, Holger, Honegger, Paul, Jacobs, Miriam, Lein, Pamela, Li, Abby, Mundy, William, Owen, David, Schneider, Steffen, Silbergeld, Ellen, Reum, Torsten, Trnovec, Tomas, Monnet-Tschudi, Florianne, and Bal-Price, Anna

Subjects
Environmental health -- Study and teaching, Risk assessment, Workshops (Educational programs), Ispra, Italy -- Conferences, meetings and seminars
Abstract

This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, [...]

Published
2007

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