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691 results on '"Prasad, Rajesh"'

157. Modulatory Effect of Rutin on the Antitumor Activity and Genotoxicity of Cisplatin in Tumor-Bearing Mice.

Author

Prasad, Rajesh and Prasad, Surya Bali

Subjects
*CISPLATIN, *CHROMOSOME abnormalities, *RUTIN, *MEMBRANE fusion, *GENETIC toxicology, *MICE, *SCANNING electron microscopy
Abstract

Purpose: Cisplatin is a cancer chemotherapeutic drug that has been extensively used in the treatment of a variety of cancers. However, the full usage of cisplatin is limited due to its treatment associated development of multiple side effects in the host. In the present study, the modulatory effect of rutin, a type of flavonoid, on the cisplatin mediated antitumor activity and allied genotoxicity in ascites Dalton's lymphoma (DL)-bearing mice were investigated. Methods: The antitumor activity was determined by calculating the percent increase in the life span of mice, cell viability and scanning electron microscopy (SEM) of DL cells. Further, the modulatory effect of rutin on the cisplatin-induced genotoxic effects in the same DL-bearing mice was assessed by the analysis of micronuclei, chromosomal aberration and sperm abnormality. Results: The combination treatment of mice with rutin and cisplatin showed a considerable increase in the life span of the DL-bearing mice depicting better antitumor efficacy. SEM of these DL cells showed severe membrane deformities in DL cells such as fusion of cell membrane, membrane blebbing, cell shrinkage, membrane folding and loss in microvilli from the tumor cell surface which may lead to cell death. Cisplatin alone treatment caused an increase in the frequency of chromosomal aberrations, micronuclei and sperms abnormality. However, the combination treatment of DL-bearing mice with rutin and cisplatin comparatively reduced these genotoxic effects. Conclusion: The overall findings suggest that rutin enhances the cisplatin-mediated antitumor activity and cytotoxicity against DL cells and at the same time diminishes the genotoxic effects induced by cisplatin in the DL-bearing mice. [ABSTRACT FROM AUTHOR]

Published
2021

158. Contributors

Author

Abdulla, Sherief, Agarwal, Josh, Apinaya Prethi, K.N., Arora, Parth, Banerjee, Ananya, Barde, Ketaki, Bendale, Shailesh Pramod, Berkani, Lamia, Bhadoria, Robin Singh, Bharti, Ajay Kumar, Bhatnagar, Shobhit, Bhoj, Naman, Chandra, Nilesh, Deshpande, Santosh L., Diwedi, Anuj, Dubey, Rahul Kumar, Eyoh, Imo J., Ganesan, A., Gupta, Ashray, Gupta, Manu K., Gusev, Marjan, Hari, Rajeswary, Hariharan, U., Haroon, Mohd, Harshvardhan, Hemachandra, Nandyala, Jain, Shashi, Jijina, G.O., Kalaivani, A., Kaliwal, Rohit B., Kanimozhi, N., Kanya, N., Kashyap, Ramgopal, Kashyap, Harsh, Kerboua, Imene Lydia, Khakhar, Param, Kumar, Santosh, Kumar, Swarup, Manry, Michael, Mathew, Elezabeth, Mishra, Eesha, Murugesan, Vadivel S., Nalinashini, G., Nithya, S., Nivurruti, Megha, Nyoho, Emmanuel E., Pal, Vipin, Pandey, Rajiv, Pathak, Dharmendra, Pillai, Anju S., Ponmagal, R.S., Prasad, Jayashree Rajesh, Prasad, Rajesh Shardanand, Prathap, Boppuru Rudra, Rahamatkar, Surendra, Rajkumar, K., Rane, Chinmay, Sahai, Archana, Sangeetha, M., Saravanan, Vijayalakshmi, Saxena, Rahul, Sendilvelan, S., Sharma, Shambhavi, Shree Charran, R., Siddiqui, Zeeshan Ali, Singh, Mukul, Singh, Vaishali, Solainayagi, P., Sriram, Raghavendra, Sujatha, K., Tiwari, Ashish, Tyagi, Kanishka, Umoh, Uduak A., Woungang, Isaac, Yadav, Anju, and Zeghoud, Sofiane

Published
2022
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173. Microclimatic alteration through protective cultivation and its effect on tomato yield

Author

null PRAGYAN KUMARI, null RAJAN KUMAR OJHA, null ABHIVYAKTI, null A. WADOOD, and null RAJNISH PRASAD RAJESH

Subjects
Atmospheric Science, Forestry, Agronomy and Crop Science
Abstract

Microclimatic alteration produced by mulching with different coloured plastic sheets, inside and outside the polyhouse and its effect on yield of tomato was studied during 2012-13 at Birsa Agricultural University, Ranchi. The mean weekly minimum and maximum air temperature during last week of December to 1st week of March were found to be higher by 2 to 9 0C inside the polyhouse than open field. Relative humidity was always higher in the open field during January to February by 2 to 7 % but it was higher inside the polyhouse in the months of March to May by 4 % at 7.00 AM. Almost a similar trend at 2.00 PM was also observed but during March to April relative humidity was higher by 10 % in polyhouse condition. The maximum available light intensity inside the polyhouse was about 30 to 40 % lower than that of the open field irrespective of growth stages. Average soil temperature was found to be higher by 2 to 5 0C under open field condition than inside the polyhouse. Leaf temperature of tomato grown under polyhouse was always lower than the open field condition. These microclimatic conditions inside the polyhouse favoured the performance of tomato and fruit yield obtain from the polyhouse was 65 t ha-1 against 33 t ha-1 from the open field

Published
2014

174. Author identification with feature transformation method.

Author

Tamboli, Mubin Shoukat and Prasad, Rajesh

Subjects
*ANONYMOUS authors, *IDENTIFICATION, *ALGORITHMS, *TIME measurements, *AUTHORS
Abstract

Over the last few decades, there has been tremendous growth in online communication through different types of media. Communication via the Internet is anonymous, which causes a critical issue regarding identity tracing. Authorship identification can apply to tasks such as identifying an anonymous author, detecting plagiarism, or finding a ghostwriter. Previous research has outlined the various methods and their improvements for the identification of anonymous authors based on stylometry. However, changes in the writing style of an author over a long period has not been addressed. In this article, we propose a methodology for author identification where the writing style of an author changes. The proposed methodology consists of two phases: the first will show the change in writing style of the author and in another phase the change is mitigated by a new feature normalization technique. A novel Transform Feature to Current Time function is proposed for normalization, where features are shifted to current time and made available for further classification. A machine-learning algorithm is used to identify an author candidate. The experiments of the proposed methodology conducted on a set of text samples by several authors were collected over a different time period and the results show an improvement in performance. [ABSTRACT FROM AUTHOR]

Published
2020
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