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151. δ-SPD

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
Full Text: View/download PDF

152. Slow-Channel Congenital Myasthenic Syndrome

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
Full Text: View/download PDF

153. Spondyloepiphyseal Dysplasia Congenita

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
Full Text: View/download PDF

154. Sporadic Inclusion Body Myositis

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
Full Text: View/download PDF

155. Scapuloperoneal Syndrome, X-linked

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
Full Text: View/download PDF

156. Severe Acute Respiratory Syndrome

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
Full Text: View/download PDF

157. Subacute Painful Thyroiditis

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
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158. Spondylo-Epi-Metaphyseal Dysplasia

Author: Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional
Published: 2009
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159. Cancer Acidity and Hypertonicity Contribute to Dysfunction of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machinery

Author: Burgdorf, Sven, primary, Porubsky, Stefan, additional, Marx, Alexander, additional, and Popovic, Zoran V., additional
Published: 2020
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160. Assessment of glomerular morphological patterns by deep learning algorithms

Author: Weis, Cleo-Aron, Bindzus, Jan Niklas, Voigt, Jonas, Runz, Marlen, Hertjens, Svetlana, Gaida, Matthias M., Popovic, Zoran V., and Porubsky, Stefan
Abstract: Background: Compilation of different morphological lesion signatures is characteristic of renal pathology. Previous studies have documented the potential value of artificial intelligence (AI) in recognizing relatively clear-cut glomerular structures and patterns, such as segmental or global sclerosis or mesangial hypercellularity. This study aimed to test the capacity of deep learning algorithms to recognize complex glomerular structural changes that reflect common diagnostic dilemmas in nephropathology. Methods: For this purpose, we defined nine classes of glomerular morphological patterns and trained twelve convolutional neuronal network (CNN) models on these. The two-step training process was done on a first dataset defined by an expert nephropathologist (12,253 images) and a second consensus dataset (11,142 images) defined by three experts in the field. Results: The efficacy of CNN training was evaluated using another set with 180 consensus images, showing convincingly good classification results (kappa-values 0.838–0.938). Conclusions: In summary, our model, focusing on glomerular lesions detectable by conventional microscopy, is the first sui generisto deploy deep learning as a reliable and promising tool in recognition of even discrete and/or overlapping morphological changes. Our results provide a stimulus for ongoing projects that integrate further input levels next to morphology (such as immunohistochemistry, electron microscopy, and clinical information) to develop a novel tool applicable for routine diagnostic nephropathology.
Published: 2022
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161. The prognostic value of galactosylceramide-sulfotransferase (Gal3ST1) in human renal cell carcinoma.

Author: Porubsky, Stefan, Nientiedt, Malin, Kriegmair, Maximilian C., Siemoneit, Jörn-Helge Heinrich, Sandhoff, Roger, Jennemann, Richard, Borgmann, Hendrik, Gaiser, Timo, Weis, Cleo-Aron, Erben, Philipp, Hielscher, Thomas, and Popovic, Zoran V.
Subjects: SULFOTRANSFERASES, RENAL cell carcinoma, ANTIGENS, TUMOR microenvironment, CELL culture
Abstract: Renal cell carcinoma (RCC) is the deadliest primary genitourinary malignancy typically associated with asymptomatic initial presentation and poorly predictable survival. Next to established risk factors, tumor microenvironment may alter metastatic capacity and immune landscape. Due to their high concentrations, sulfoglycolipids (sulfatides) were among the first well-described antigens in RCC that are associated with worse prognosis. As sulfatide detection in routine diagnostics is not possible, we aimed to test the prognostic value of its protein counterpart, sulfatide-producing enzyme Gal3ST1. We performed retrospective long-term follow up analysis of Gal3ST1 expression as prognostic risk factor in a representative RCC patient cohort. We observed differentially regulated Gal3ST1 expression in all RCC types, being significantly more associated with clear cell RCC than to chromophobe RCC (p = 0.001). Surprisingly, in contrast to published observations from in vitro models, we could not confirm an association between Gal3ST1 expression and a malignant clinical behaviour of the RCC. In our cohort, Gal3ST1 did not significantly influence progression-free survival (Hazard Ratio (HR): 1.7 95% CI (0.6–4.9), p = 0.327). Particularly after adjusting for histology, T-stage, N-status and M-status at baseline, we observed no independent prognostic effect (HR = 1.0 95% CI (0.3–3.3), p = 0.96). The analysis of Gal3ST1 mRNA expression in a TCGA dataset supported the results of our cohort. Thus, Gal3ST1 might help to differentiate between chromophobe RCC and other frequent RCC entities but—despite previously published data from cell culture models—does not qualify as a prognostic marker for RCC. Further investigation of regulatory mechanisms of sulfatide metabolism in human RCC microenvironment is necessary to understand the role of this quantitatively prominent glycosphingolipid in RCC progression. [ABSTRACT FROM AUTHOR]
Published: 2021
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162. A comprehensive molecular characterization of the 8q22.2 region reveals the prognostic relevance of OSR2 mRNA in muscle invasive bladder cancer.

Author: Uysal, Daniel, Kowalewski, Karl-Friedrich, Kriegmair, Maximilian Christian, Wirtz, Ralph, Popovic, Zoran V., and Erben, Philipp
Subjects: CANCER invasiveness, BLADDER cancer, GENETIC overexpression, GENES, MESSENGER RNA, GENE amplification, RIBOSOMAL DNA
Abstract: Technological advances in molecular profiling have enabled the comprehensive identification of common regions of gene amplification on chromosomes (amplicons) in muscle invasive bladder cancer (MIBC). One such region is 8q22.2, which is largely unexplored in MIBC and could harbor genes with potential for outcome prediction or targeted therapy. To investigate the prognostic role of 8q22.2 and to compare different amplicon definitions, an in-silico analysis of 357 patients from The Cancer Genome Atlas, who underwent radical cystectomy for MIBC, was performed. Amplicons were generated using the GISTIC2.0 algorithm for copy number alterations (DNA_Amplicon) and z-score normalization for mRNA gene overexpression (RNA_Amplicon). Kaplan-Meier survival analysis, univariable, and multivariable Cox proportional hazard ratios were used to relate amplicons, genes, and clinical parameters to overall (OS) and disease-free survival (DFS). Analyses of the biological functions of 8q22.2 genes and genomic events in MIBC were performed to identify potential targets. Genes with prognostic significance from the in silico analysis were validated using RT-qPCR of MIBC tumor samples (n = 46). High 8q22.2 mRNA expression (RNA-AMP) was associated with lymph node metastases. Furthermore, 8q22.2 DNA and RNA amplified patients were more likely to show a luminal subtype (DNA_Amplicon_core: p = 0.029; RNA_Amplicon_core: p = 0.01). Overexpression of the 8q22.2 gene OSR2 predicted shortened DFS in univariable (HR [CI] 1.97 [1.2; 3.22]; p = 0.01) and multivariable in silico analysis (HR [CI] 1.91 [1.15; 3.16]; p = 0.01) and decreased OS (HR [CI] 6.25 [1.37; 28.38]; p = 0.0177) in RT-qPCR data analysis. Alterations in different levels of the 8q22.2 region are associated with manifestation of different clinical characteristics in MIBC. An in-depth comprehensive molecular characterization of genomic regions involved in cancer should include multiple genetic levels, such as DNA copy number alterations and mRNA gene expression, and could lead to a better molecular understanding. In this study, OSR2 is identified as a potential biomarker for survival prognosis. [ABSTRACT FROM AUTHOR]
Published: 2021
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163. Molecular pathology of thymomas: implications for diagnosis and therapy.

Author: Marx, Alexander, Belharazem, Djeda, Lee, De-Hyung, Popovic, Zoran V., Reißfelder, Christoph, Schalke, Berthold, Schölch, Sebastian, Ströbel, Philipp, Weis, Cleo-Aron, and Yamada, Yosuke
Abstract: Thymomas exhibit a unique genomic landscape, comprising the lowest on average total mutational burden among adult human cancers; a unique point mutation in the GTF2I gene in WHO type A and AB thymomas (and rarely others); almost unique KMT2A-MAML2 translocations in rare WHO type B2 and B3 thymomas; a unique YAP1-MAML2 translocation in almost all metaplastic thymomas; and unique miRNA profiles in relation to GTF2I mutational status and WHO histotypes. While most thymomas can be diagnosed solely on the basis of morphological features, mutational analyses can solve challenging differential diagnostic problems. No molecular biomarkers have been identified that predict the response of unresectable thymomas to chemotherapy or agents with known molecular targets. Despite the common and strong expression of PDL1 in thymomas, immune checkpoint inhibitors are rarely applicable due to the poor predictability of common, life-threatening autoimmune side effects that are related to the unrivaled propensity of thymomas towards autoimmunity. [ABSTRACT FROM AUTHOR]
Published: 2021
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164. Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis

Author: Jennemann, Richard, primary, Federico, Giuseppina, additional, Mathow, Daniel, additional, Rabionet, Mariona, additional, Rampoldi, Francesca, additional, Popovic, Zoran V., additional, Volz, Martina, additional, Hielscher, Thomas, additional, Sandhoff, Roger, additional, and Gröne, Hermann-Josef, additional
Published: 2017
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165. Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells

Author: Popovic, Zoran V., primary, Rabionet, Mariona, additional, Jennemann, Richard, additional, Krunic, Damir, additional, Sandhoff, Roger, additional, Gröne, Hermann-Josef, additional, and Porubsky, Stefan, additional
Published: 2017
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166. Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner

Author: Popovic, Zoran V., primary, Embgenbroich, Maria, additional, Chessa, Federica, additional, Nordström, Viola, additional, Bonrouhi, Mahnaz, additional, Hielscher, Thomas, additional, Gretz, Norbert, additional, Wang, Shijun, additional, Mathow, Daniel, additional, Quast, Thomas, additional, Schloetel, Jan-Gero, additional, Kolanus, Waldemar, additional, Burgdorf, Sven, additional, and Gröne, Hermann-Josef, additional
Published: 2017
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167. Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells

Author: Rampoldi, Francesca, primary, Brunk, Fabian, additional, Bonrouhi, Mahnaz, additional, Federico, Giuseppina, additional, Krunic, Damir, additional, Porubsky, Stefan, additional, Gröne, Hermann-Josef, additional, and Popovic, Zoran V, additional
Published: 2017
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168. Transcriptional profiling of dendritic cells matured in different osmolarities

Author: Chessa, Federica, primary, Hielscher, Thomas, additional, Mathow, Daniel, additional, Gröne, Hermann-Josef, additional, and Popovic, Zoran V., additional
Published: 2016
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169. Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis

Author: Federico, Giuseppina, primary, Meister, Michael, additional, Mathow, Daniel, additional, Heine, Gunnar H., additional, Moldenhauer, Gerhard, additional, Popovic, Zoran V., additional, Nordström, Viola, additional, Kopp-Schneider, Annette, additional, Hielscher, Thomas, additional, Nelson, Peter J., additional, Schaefer, Franz, additional, Porubsky, Stefan, additional, Fliser, Danilo, additional, Arnold, Bernd, additional, and Gröne, Hermann-Josef, additional
Published: 2016
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170. The renal microenvironment modifies dendritic cell phenotype

Author: Chessa, Federica, primary, Mathow, Daniel, additional, Wang, Shijun, additional, Hielscher, Thomas, additional, Atzberger, Ann, additional, Porubsky, Stefan, additional, Gretz, Norbert, additional, Burgdorf, Sven, additional, Gröne, Hermann-Josef, additional, and Popovic, Zoran V., additional
Published: 2016
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171. Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation

Author: Rampoldi, Francesca, primary, Bonrouhi, Mahnaz, additional, Boehm, Martin E., additional, Lehmann, Wolf D., additional, Popovic, Zoran V., additional, Kaden, Sylvia, additional, Federico, Giuseppina, additional, Brunk, Fabian, additional, Gröne, Hermann-Josef, additional, and Porubsky, Stefan, additional
Published: 2015
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172. Dickkopf-3, a Tissue-Derived Modulator of Local T-Cell Responses

Author: Meister, Michael, primary, Papatriantafyllou, Maria, additional, NordstrÃ¶m, Viola, additional, Kumar, Varun, additional, Ludwig, Julia, additional, Lui, Kathy O., additional, Boyd, Ashleigh S., additional, Popovic, Zoran V., additional, Fleming, Thomas Henry, additional, Moldenhauer, Gerhard, additional, Nawroth, Peter P., additional, GrÃ¶ne, Hermann-Josef, additional, Waldmann, Herman, additional, Oelert, Thilo, additional, and Arnold, Bernd, additional
Published: 2015
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173. Biomarker and micropetrographic investigations of coal from the Krepoljin Brown Coal Basin Serbia

Author: Dević, Gordana, Popovic, Zoran V., Dević, Gordana, and Popovic, Zoran V.
Abstract: We investigated early diagenetic processes of the extractable organic matter from the Miocene freshwater sequence, which consists of coal fragments in clays, sandstones and shales alternating with continuous brown coal layers. We examined eight coals, thirteen sediments and three non-coaly underground layers. The molecular assemblages of the identified aliphatic hydrocarbons in the Krepoljin Basin reflect the abundance of plant taxa as precursors or participants in the early diagenetic stage. The data provide insight into the conditions prevailing in the lakes and bogs during early diagenesis. The dominance of diterpanes indicates that the prevalent of the organic matter was of gymnosperous origin. The hopanoid contents are considered to reflect microbial activity. That the organic matter in the Miocene Krepoljin Coal Basin is immature was confirmed by the presence of biolipids such as beta beta-hopanes, C-27 17 beta (H)-trisnorhopane. Saturated and aromatized abietanes, pimaranes and phyllocladanes, the most abundant compounds in all samples, indicate a predominantly higher plant input related to the Coniferous group, but identification of the individual plant families was not possible. beta-Amyrin and other triterpenoid-derived triaromatic and triaromatic C-ring cleaved hydrocarbons with triterpenoid structures are thought to be characteristic for angiosperms. Unsaturated compounds, Delta(2)-triterpanes, early intermediaries in the diagenetic transformation of angiosperms also indicate a low degree of sediment maturity. Crown Copyright
Published: 2013

174. The proteoglycan biglycan enhances antigen‐specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis

Author: Groene, Hermann-Josef, primary, Wang, Shijun, additional, Papatriantafyllou, Maria, additional, Kaya, Ziya, additional, Burgdorf, Sven, additional, Young, Marian F., additional, Schaefer, Liliana, additional, and Popovic, Zoran V., additional
Published: 2012
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175. Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-?-producing ?d T cells

Author: Rampoldi, Francesca, Brunk, Fabian, Bonrouhi, Mahnaz, Federico, Giuseppina, Krunic, Damir, Porubsky, Stefan, Gröne, Hermann-Josef, and Popovic, Zoran V.
Abstract: Calcineurin-Nfatc pathway promotes development and function of IFN?-producing ?d T cells. ?d T cell subsets can be characterized, in part, by their secretion of select proinflammatory cytokines. The molecular mechanisms driving the diverse fates of ?d T cells have not been elucidated. We have previously shown that the attachment of myristic acid to the N-terminal glycine of proteins, termed N-myristoylation, is essential for aß T cell development and activation. Here, we explore the potential role of this lipid modification on the activation of ?d T cells. In the absence of N-myristoylation, the CD27+?d T cell subset was dominantly affected. The cells produced high levels of IFN-? upon stimulation. In addition, they were more sensitive to inhibition of the CaN-Nfat pathway than were ?d T cells with myristoylated CaN. N-Myristoylation was found to modulate activity of phosphatase CaN, a regulator of Nfat. In summary, the CaN–Nfat pathway regulates development and function of IFN-?-producing ?d T cells, and its balanced activity is strongly dependent on CaN N-myristoylation.
Published: 2017
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176. The Proteoglycan Biglycan Enhances Antigen-Specific T Cell Activation Potentially via MyD88 and TRIF Pathways and Triggers Autoimmune Perimyocarditis

Author: Popovic, Zoran V., primary, Wang, Shijun, additional, Papatriantafyllou, Maria, additional, Kaya, Ziya, additional, Porubsky, Stefan, additional, Meisner, Maria, additional, Bonrouhi, Mahnaz, additional, Burgdorf, Sven, additional, Young, Marian F., additional, Schaefer, Liliana, additional, and Gröne, Hermann-Josef, additional
Published: 2011
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177. Peroxisome Proliferator-Activated Receptor (PPAR)γ Can Inhibit Chronic Renal Allograft Damage

Author: Kiss, Eva, primary, Popovic, Zoran V., additional, Bedke, Jens, additional, Adams, Judith, additional, Bonrouhi, Mahnaz, additional, Babelova, Andrea, additional, Schmidt, Claudia, additional, Edenhofer, Frank, additional, Zschiedrich, Inka, additional, Domhan, Sophie, additional, Abdollahi, Amir, additional, Schäfer, Liliana, additional, Gretz, Norbert, additional, Porubsky, Stefan, additional, and Gröne, Hermann-Josef, additional
Published: 2010
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178. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling

Author: Wang, Shijun, primary, Schmaderer, Christoph, additional, Kiss, Eva, additional, Schmidt, Claudia, additional, Bonrouhi, Mahnaz, additional, Porubsky, Stefan, additional, Gretz, Norbert, additional, Schaefer, Liliana, additional, Kirschning, Carsten J., additional, Popovic, Zoran V., additional, and Gröne, Hermann-Josef, additional
Published: 2010
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179. Spectroscopic ellipsometry and polarimetry for materials and systems analysis at the nanometer scale: state-of-the-art, potential, and perspectives

Author: Losurdo, Maria, primary, Bergmair, Michael, additional, Bruno, Giovanni, additional, Cattelan, Denis, additional, Cobet, Christoph, additional, de Martino, Antonello, additional, Fleischer, Karsten, additional, Dohcevic-Mitrovic, Zorana, additional, Esser, Norbert, additional, Galliet, Melanie, additional, Gajic, Rados, additional, Hemzal, Dušan, additional, Hingerl, Kurt, additional, Humlicek, Josef, additional, Ossikovski, Razvigor, additional, Popovic, Zoran V., additional, and Saxl, Ottilia, additional
Published: 2009
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180. Sulfated Glycosphingolipid as Mediator of Phagocytosis: SM4s Enhances Apoptotic Cell Clearance and Modulates Macrophage Activity

Author: Popovic, Zoran V., primary, Sandhoff, Roger, additional, Sijmonsma, Tjeerd P., additional, Kaden, Sylvia, additional, Jennemann, Richard, additional, Kiss, Eva, additional, Tone, Edgar, additional, Autschbach, Frank, additional, Platt, Nick, additional, Malle, Ernst, additional, and Gröne, Hermann-Josef, additional
Published: 2007
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181. Anti-Inflammatory Effects of αv Integrin Antagonism in Acute Kidney Allograft Rejection

Author: Bedke, Jens, primary, Kiss, Eva, additional, Behnes, Carl-Ludwig, additional, Popovic, Zoran V., additional, Heuser, Markus, additional, Stojanovic, Tomislav, additional, Sijmonsma, Tjeerd, additional, Huber, Peter, additional, Domhan, Sophie, additional, Muschal, Stefan, additional, Abdollahi, Amir, additional, Gretz, Norbert, additional, and Gröne, Hermann-Josef, additional
Published: 2007
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182. CD73 Overexpression in Podocytes: A Novel Marker of Podocyte Injury in Human Kidney Disease.

Author: Popovic, Zoran V., Bestvater, Felix, Krunic, Damir, Krämer, Bernhard K., Bergner, Raoul, Löffler, Christian, Hocher, Berthold, Marx, Alexander, and Porubsky, Stefan
Subjects: *KIDNEY diseases, *FOCAL segmental glomerulosclerosis, *CHEMOKINE receptors, *KIDNEY injuries, *RENAL biopsy, *LABORATORY mice
Abstract: The CD73 pathway is an important anti-inflammatory mechanism in various disease settings. Observations in mouse models suggested that CD73 might have a protective role in kidney damage; however, no direct evidence of its role in human kidney disease has been described to date. Here, we hypothesized that podocyte injury in human kidney diseases alters CD73 expression that may facilitate the diagnosis of podocytopathies. We assessed the expression of CD73 and one of its functionally important targets, the C-C chemokine receptor type 2 (CCR2), in podocytes from kidney biopsies of 39 patients with podocytopathy (including focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranous glomerulonephritis (MGN) and amyloidosis) and a control group. Podocyte CD73 expression in each of the disease groups was significantly increased in comparison to controls (p < 0.001–p < 0.0001). Moreover, there was a marked negative correlation between CD73 and CCR2 expression, as confirmed by immunohistochemistry and immunofluorescence (Pearson r = −0.5068, p = 0.0031; Pearson r = −0.4705, p = 0.0313, respectively), thus suggesting a protective role of CD73 in kidney injury. Finally, we identify CD73 as a novel potential diagnostic marker of human podocytopathies, particularly of MCD that has been notorious for the lack of pathological features recognizable by light microscopy and immunohistochemistry. [ABSTRACT FROM AUTHOR]
Published: 2021
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183. Anti-Inflammatory Effects of αvIntegrin Antagonism in Acute Kidney Allograft Rejection

Author: Bedke, Jens, Kiss, Eva, Behnes, Carl-Ludwig, Popovic, Zoran V., Heuser, Markus, Stojanovic, Tomislav, Sijmonsma, Tjeerd, Huber, Peter, Domhan, Sophie, Muschal, Stefan, Abdollahi, Amir, Gretz, Norbert, and Gröne, Hermann-Josef
Abstract: Integrin-mediated cell adhesion and signaling is essential to vascular development and inflammatory processes. Elevated expression of integrin αvβ3has been detected in ischemia-reperfusion injury and rejecting heart allografts. We thus hypothesized that the inhibition of αv-associated integrins may have potent anti-inflammatory effects in acute kidney allograft rejection. We studied the effects of a peptidomimetic antagonist of αvintegrins in two rat models of renal allotransplantation, differing in degree of major histocompatibility complex mismatch. Integrin αvβ3was up-regulated in rejecting renal allografts. Integrin antagonist reduced the histological signs of acute rejection, the intensity of the mononuclear cell infiltration, and cell proliferation in the grafted kidneys. This could be correlated to a reduced leukocyte-endothelial interaction and an improved peritubular microcirculation observed by intravital microscopy. In vitrounder laminar flow conditions, the arrest of monocytes to interleukin-1β-activated endothelium was decreased. Furthermore, in co-culture models the proliferation and transmigration of monocytes/macrophages, endothelium, and fibroblasts induced by renal tubular epithelia was efficiently inhibited by αvintegrin antagonism. These data reveal an important role of this integrin subclass in leukocyte recruitment and development and maintenance of acute rejection; blockade of αvintegrins may provide a new therapeutic strategy to attenuate acute allograft rejection.
Published: 2007
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184. Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases.

Author: Porubsky, Stefan, Popovic, Zoran V., Badve, Sunil, Banz, Yara, Berezowska, Sabina, Borchert, Dietmar, Brüggemann, Monika, Gaiser, Timo, Graeter, Thomas, Hollaus, Peter, Huettl, Katrin S., Kotrova, Michaela, Kreft, Andreas, Kugler, Christian, Lötscher, Fabian, Möller, Burkhard, Ott, German, Preissler, Gerhard, Roessner, Eric, and Rosenwald, Andreas
Subjects: *AUTOIMMUNE diseases, *EPITHELIAL cells, *LYMPHOID tissue, *LYMPHOMAS, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *THYMUS hyperplasia, *SIALADENITIS
Abstract: Simple Summary: Thymic epithelial tumors and lymphomas are the most frequent mediastinal mass lesions. Thymic hyperplasia with "lymphoepithelial sialadenitis (LESA)-like features" (LESA-like TH) was initially described as one form of thymic hyperplasia and was thought not to be associated with autoimmune and lymphoproliferative diseases. Our systematic analysis of patients with LESA-like TH shows that 14% have associated lymphomas and 33% partially overlapping autoimmune diseases. This implies a hematologic and rheumatologic workup in patients with LESA-like TH. In addition, LESA-like TH should enter the list of differential diagnoses of mediastinal mass lesions, in particular in patients with autoimmune diseases. Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32–80; lesion diameter 7.0 cm, 1–14.5; median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumatoid arthritis (n = 3, 8%), myasthenia gravis (n = 2, 6%), asthma (n = 2, 6%), scleroderma, Sjögren syndrome, pure red cell aplasia, Grave's disease and anti-IgLON5 syndrome (each n = 1, 3%). Among 11 primary thymic MALT lymphomas, remnants of LESA-like TH were found in two cases (18%). In summary, LESA-like TH shows a striking association with autoimmunity and predisposes to lymphomas. Thus, a hematologic and rheumatologic workup should become standard in patients diagnosed with LESA-like TH. Radiologists and clinicians should be aware of LESA-like TH as a differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases. [ABSTRACT FROM AUTHOR]
Published: 2021
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185. Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases

Author: Porubsky, Stefan, Popovic, Zoran V, Badve, Sunil, Banz, Yara, Berezowska, Sabina, Borchert, Dietmar, Br��ggemann, Monika, Gaiser, Timo, Graeter, Thomas, Hollaus, Peter, Huettl, Katrin S, Kotrova, Michaela, Kreft, Andreas, Kugler, Christian, L��tscher, Fabian, M��ller, Burkhard, Ott, German, Preissler, Gerhard, Roessner, Eric, Rosenwald, Andreas, Str��bel, Philipp, and Marx, Alexander
Subjects: immune system diseases, hemic and lymphatic diseases, 570 Life sciences, biology, 610 Medicine & health, 3. Good health
Abstract: Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32-80; lesion diameter 7.0 cm, 1-14.5; median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumatoid arthritis (n = 3, 8%), myasthenia gravis (n = 2, 6%), asthma (n = 2, 6%), scleroderma, Sj��gren syndrome, pure red cell aplasia, Grave's disease and anti-IgLON5 syndrome (each n = 1, 3%). Among 11 primary thymic MALT lymphomas, remnants of LESA-like TH were found in two cases (18%). In summary, LESA-like TH shows a striking association with autoimmunity and predisposes to lymphomas. Thus, a hematologic and rheumatologic workup should become standard in patients diagnosed with LESA-like TH. Radiologists and clinicians should be aware of LESA-like TH as a differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases.

186. Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma.

Author: Walach, Margarete Teresa, Nitschke, Katja, Groß-Weege, Matthias, Großhans, Johannes, Wildner, Lukas, Pause, Luca, Jarczyk, Jonas, Wessels, Frederik, Neuberger, Manuel, Kowalewski, Karl-Friedrich, Kriegmair, Maximilian Christian, Popovic, Zoran V., Gaiser, Timo, Worst, Thomas Stefan, and Nuhn, Philipp
Subjects: *GENE expression, *REVERSE transcriptase polymerase chain reaction, *TRANSITIONAL cell carcinoma, *UROTHELIUM, *BIOMARKERS, *CYCLINS
Abstract: Introduction: The aim was to evaluate the prognostic value of altered Cyclin A2 (CCNA2) gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival. Methods: 62 patients who underwent surgical treatment for UTUC were included. Gene expression of CCNA2, MKI67, and p53 was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of CCNA2 expression with MKI67 and p53. Results: The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high CCNA2 expression levels showed longer OS (HR 0.33; 95% CI: 0.15–0.74; p = 0.0073). Multivariable Cox regression analyses identified CCNA2 overexpression (HR 0.37; 95% CI: 0.16–0.85; p = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17–0.87; p = 0.0168) to be independent predictors for longer OS. CCNA2 expression correlated positively with MKI67 expression (Rho = 0.4376, p = 0.0005). Conclusion: Low CCNA2 expression is significantly associated with worse OS. Thus, CCNA2 might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores. [ABSTRACT FROM AUTHOR]
Published: 2024
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187. A self-supervised vision transformer to predict survival from histopathology in renal cell carcinoma.

Author: Wessels, Frederik, Schmitt, Max, Krieghoff-Henning, Eva, Nientiedt, Malin, Waldbillig, Frank, Neuberger, Manuel, Kriegmair, Maximilian C., Kowalewski, Karl-Friedrich, Worst, Thomas S., Steeg, Matthias, Popovic, Zoran V., Gaiser, Timo, von Kalle, Christof, Utikal, Jochen S., Fröhling, Stefan, Michel, Maurice S., Nuhn, Philipp, and Brinker, Titus J.
Subjects: *RENAL cell carcinoma, *FEATURE extraction, *DEEP learning, *RENAL cancer, *REGRESSION analysis
Abstract: Purpose: To develop and validate an interpretable deep learning model to predict overall and disease-specific survival (OS/DSS) in clear cell renal cell carcinoma (ccRCC). Methods: Digitised haematoxylin and eosin-stained slides from The Cancer Genome Atlas were used as a training set for a vision transformer (ViT) to extract image features with a self-supervised model called DINO (self-distillation with no labels). Extracted features were used in Cox regression models to prognosticate OS and DSS. Kaplan–Meier for univariable evaluation and Cox regression analyses for multivariable evaluation of the DINO-ViT risk groups were performed for prediction of OS and DSS. For validation, a cohort from a tertiary care centre was used. Results: A significant risk stratification was achieved in univariable analysis for OS and DSS in the training (n = 443, log rank test, p < 0.01) and validation set (n = 266, p < 0.01). In multivariable analysis, including age, metastatic status, tumour size and grading, the DINO-ViT risk stratification was a significant predictor for OS (hazard ratio [HR] 3.03; 95%-confidence interval [95%-CI] 2.11–4.35; p < 0.01) and DSS (HR 4.90; 95%-CI 2.78–8.64; p < 0.01) in the training set but only for DSS in the validation set (HR 2.31; 95%-CI 1.15–4.65; p = 0.02). DINO-ViT visualisation showed that features were mainly extracted from nuclei, cytoplasm, and peritumoural stroma, demonstrating good interpretability. Conclusion: The DINO-ViT can identify high-risk patients using histological images of ccRCC. This model might improve individual risk-adapted renal cancer therapy in the future. [ABSTRACT FROM AUTHOR]
Published: 2023
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188. Publisher's Note: 'Preface to Special Issue: Renewable Energy in South-Eastern Europe' [J. Renewable Sustainable Energy 5, 041701 (2013)].

Author: Badescu, Viorel, Popovic, Zoran V., Fara, Laurentiu, and Bojic, Milorad
Subjects: *RENEWABLE energy sources, *ALTERNATIVE fuels
Abstract: A correction to the article "Preface to Special Issue: Renewable Energy in South-Eastern Europe" that was published online on June 27, 2013 is presented.
Published: 2013
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189. Preface to Special Issue: Renewable Energy in South-Eastern Europe.

Author: Badescu, Viorel, Popovic, Zoran V., Fara, Laurentiu, and Bojic, Milorad
Subjects: *SOLAR radiation, *PARABOLIC troughs, *ELECTRIC power distribution
Abstract: An introduction is presented in which the authors discuss various articles within the issue on topics including the clear sky solar radiation over Romanian territory, sea-shell stationary trough solar concentrator for heat production, and hybrid autonomous electricity supply system.
Published: 2013
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190. Deep learning can predict survival directly from histology in clear cell renal cell carcinoma.

Author: Wessels, Frederik, Schmitt, Max, Krieghoff-Henning, Eva, Kather, Jakob N., Nientiedt, Malin, Kriegmair, Maximilian C., Worst, Thomas S., Neuberger, Manuel, Steeg, Matthias, Popovic, Zoran V., Gaiser, Timo, von Kalle, Christof, Utikal, Jochen S., Fröhling, Stefan, Michel, Maurice S., Nuhn, Philipp, and Brinker, Titus J.
Subjects: *RENAL cell carcinoma, *DEEP learning, *RECEIVER operating characteristic curves, *CONVOLUTIONAL neural networks
Abstract: For clear cell renal cell carcinoma (ccRCC) risk-dependent diagnostic and therapeutic algorithms are routinely implemented in clinical practice. Artificial intelligence-based image analysis has the potential to improve outcome prediction and thereby risk stratification. Thus, we investigated whether a convolutional neural network (CNN) can extract relevant image features from a representative hematoxylin and eosin-stained slide to predict 5-year overall survival (5y-OS) in ccRCC. The CNN was trained to predict 5y-OS in a binary manner using slides from TCGA and validated using an independent in-house cohort. Multivariable logistic regression was used to combine of the CNNs prediction and clinicopathological parameters. A mean balanced accuracy of 72.0% (standard deviation [SD] = 7.9%), sensitivity of 72.4% (SD = 10.6%), specificity of 71.7% (SD = 11.9%) and area under receiver operating characteristics curve (AUROC) of 0.75 (SD = 0.07) was achieved on the TCGA training set (n = 254 patients / WSIs) using 10-fold cross-validation. On the external validation cohort (n = 99 patients / WSIs), mean accuracy, sensitivity, specificity and AUROC were 65.5% (95%-confidence interval [CI]: 62.9–68.1%), 86.2% (95%-CI: 81.8–90.5%), 44.9% (95%-CI: 40.2–49.6%), and 0.70 (95%-CI: 0.69–0.71). A multivariable model including age, tumor stage and metastasis yielded an AUROC of 0.75 on the TCGA cohort. The inclusion of the CNN-based classification (Odds ratio = 4.86, 95%-CI: 2.70–8.75, p < 0.01) raised the AUROC to 0.81. On the validation cohort, both models showed an AUROC of 0.88. In univariable Cox regression, the CNN showed a hazard ratio of 3.69 (95%-CI: 2.60–5.23, p < 0.01) on TCGA and 2.13 (95%-CI: 0.92–4.94, p = 0.08) on external validation. The results demonstrate that the CNN's image-based prediction of survival is promising and thus this widely applicable technique should be further investigated with the aim of improving existing risk stratification in ccRCC. [ABSTRACT FROM AUTHOR]
Published: 2022
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191. Upper Tract Urinary Cancer Recurrence after Radical Cystectomy: Risk Assessment of Intraoperative Frozen Section.

Author: Nientiedt, Malin, Waldbillig, Frank, Stroop, Felix, Nuhn, Philipp, Erben, Philipp, Popovic, Zoran V., Weis, Cleo-Aron, Michel, Maurice Stephan, and Kriegmair, Maximilian C.
Subjects: *CANCER relapse, *URINARY organs, *CYSTECTOMY, *RISK assessment, *BLADDER cancer, *SURGICAL margin
Abstract: Introduction: Upper tract urinary cancer recurrence (UTUCR) after radical cystectomy (RC) is outcome-limiting. Surgical recommendations on intraoperative performance of frozen section analysis (FSA) and management of positive ureteral margin (PUM) are lacking. Methods: 634 RC cases were identified (2010–2018). In patients with PUM, sequential ureteral resections up to a negative margin were performed. We investigated the accuracy of FSA, significance of PUM, and identified risk factors (RFs) to stratify patients for UTUCR. Results: FSA was performed in 355 patients, including a total of 693 ureters. FSA sensitivity was 0.93 and specificity 0.99. PUM conversion was possible in 52 (91.2%) cases. UTUCR occurred in 17 (4.8%) patients. Identified UTUCR RFs are non-muscle invasive bladder carcinoma (NMIBC) (OR 3.8, 95% confidence intervals [CI] 1.4–10.2, p = 0.008), multifocal bladder cancer in cystectomy specimen (OR 4.7, CI 1.1–20.8, p = 0.042), and recurrent NMIBC (OR 4.1, CI 1.5–10.9, p = 0.006). Risk-group stratification showed a six-fold increase in UTUCR risk (low-to high-risk). Conclusion: FSA is a sensitive and specific method to identify PUM. UTUCR occurs significantly more often in patients with recurrent, multifocal NMIBC at the time of RC. Patients can be risk stratified for UTUCR. In case of NMIBC-PUM, surgeons can safely opt for a kidney preserving strategy. [ABSTRACT FROM AUTHOR]
Published: 2022
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192. Post-COVID-19 complement-mediated TMA: A case report.

Author: Jochims JA, Yazdani B, Krüger B, Popovic ZV, and Krämer BK
Subjects: Humans, Male, Aged, SARS-CoV-2, Glucocorticoids therapeutic use, Plasma Exchange, Antibodies, Monoclonal, Humanized therapeutic use, Acute Kidney Injury therapy, Acute Kidney Injury etiology, Acute Kidney Injury diagnosis, Complement Inactivating Agents therapeutic use, Renal Dialysis, COVID-19 complications, COVID-19 therapy, Thrombotic Microangiopathies therapy, Thrombotic Microangiopathies etiology, Thrombotic Microangiopathies diagnosis
Abstract: Systemic COVID-19 disease is associated with a variety of organ involvement in infected patients. A rarely reported complication is the induction of complement-mediated thrombotic microangiopathy (TMA). TMA is an extremely rare pathological condition that results in thrombosis in capillaries and small arterioles, due to an endothelial injury. It is often combined with thrombocytopenia, Coombs-negative hemolytic anemia, and end-organ damage. This case involves a patient who was admitted to our hospital for the purpose of diagnosis and treatment of acute kidney injury (AKIN 3) with severe proteinuria after a preceding SARS-CoV-2 infection. A 77-year-old male patient had COVID-19 pneumonia in January 2021 with the need of high-flow oxygen therapy in the intensive care unit. In March 2021, he was hospitalized again due to elevated serum creatinine levels and proteinuria. The patient exhibited normal vital parameters. A renal biopsy showed severe TMA. A diagnosis of COVID-19-associated TMA was made, and treatment with high-dose glucocorticoid therapy and plasma exchange was initiated. Additionally, therapy with eculizumab was established. Unfortunately, the kidney failure was initially progressive, so that hemodialysis (HD) was temporarily necessary. In May 2021, kidney function recovered to an estimated glomerular filtration rate of ~ 30 mL/min/1.73m 2 corresponding to chronic kidney disease stage 3bA3 - 4A3. COVID-19-associated TMA is an extremely rare disease. TMA may be a possible long-term complication with the risk of end-stage renal disease if not properly diagnosed and treated.
Published: 2024
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193. Prognostic significance of EGFR, AREG and EREG amplification and gene expression in muscle invasive bladder cancer.

Author: Uysal D, Thaqi B, Fierek A, Jurgowski D, Popovic ZV, Siegel F, Michel MS, Nuhn P, Worst TS, Erben P, and Nitschke K
Abstract: Introduction: Muscle invasive bladder cancer (MIBC) remains a prevalent cancer with limited therapeutic options, obviating the need for innovative therapies. The epidermal growth factor receptor ( EGFR ) is a linchpin in tumor progression and presents a potential therapeutic target in MIBC. Additionally, the EGFR ligands AREG and EREG have shown associations with response to anti-EGFR therapy and improved progression-free survival in colorectal carcinoma., Materials and Methods: We investigated the prognostic significance of EGFR , AREG , and EREG in MIBC. Gene expression and copy number analyses were performed via qRT-PCR on tissue samples from 100 patients with MIBC who underwent radical cystectomy at the University Hospital Mannheim (MA; median age 72, interquartile range [IQR] 64-78 years, 25% female). Results were validated in 361 patients from the 2017 TCGA MIBC cohort (median age 69, IQR 60-77 years, 27% female), in the Chungbuk and MDACC cohort. Gene expressions were correlated with clinicopathologic parameters using the Mann-Whitney test, Kruskal-Wallis- test and Spearman correlation. For overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) gene expression was analyzed with Kaplan-Meier and Cox-proportional hazard models., Results: Significant gene expression differences in EGFR , AREG , and EREG could be detected in all cohorts. In the TCGA cohort, EGFR expression was significantly elevated in patients with EGFR amplification and KRAS wildtype. High AREG expression independently predicted longer OS (HR = 0.35, CI 0.19 - 0.63, p = 0.0004) and CSS (HR = 0.42, CI 0.18 - 0.95, p = 0.0378) in the MA cohort. In the TCGA cohort, high EGFR , AREG , and EREG expression correlated with shorter OS ( AREG : HR = 1.57, CI 1.12 - 2.20, p = 0.0090) and DFS ( EGFR : HR = 1.91, CI 1.31 - 2.8, p = 0.0008). EGFR amplification was also associated with reduced DFS., Discussion: High EGFR and EREG indicate worse survival in patients with MIBC. The prognostic role of AREG should further be investigated in large, prospective series. Divergent survival outcomes between the four cohorts should be interpreted cautiously, considering differences in analysis methods and demographics. Further in vitro investigations are necessary to elucidate the functional mechanisms underlying the associations observed in this study., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Uysal, Thaqi, Fierek, Jurgowski, Popovic, Siegel, Michel, Nuhn, Worst, Erben and Nitschke.)
Published: 2024
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194. Medium-term Oncological Efficacy and Patient-reported Outcomes After Focal High-intensity Focused Ultrasound: The FOXPRO Trial.

Author: Westhoff N, Ernst R, Kowalewski KF, Derigs F, Neuberger M, Nörenberg D, Popovic ZV, Ritter M, Stephan Michel M, and von Hardenberg J
Subjects: Male, Humans, Aged, Prospective Studies, Cohort Studies, Patient Reported Outcome Measures, Prostate-Specific Antigen, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms surgery
Abstract: Background: Multiparametric magnetic resonance imaging (mpMRI)/transrectal ultrasound (TRUS) fusion-guided high-intensity focused ultrasound (HIFU) is a focal treatment option for MRI-visible localized prostate cancer (PCa). High-quality evidence regarding the clinical efficacy remains limited., Objective: To assess medium-term oncological efficacy along with patient-reported outcome measures (PROMs)., Design, Setting, and Participants: This prospective single-center cohort study was performed from 2014 to 2020. Patients with primary International Society of Urological Pathologists (ISUP) grade group (GG) ≤2 by combined MRI/TRUS fusion and systematic prostate biopsy and prostate-specific antigen (PSA) <10 ng/ml were included., Intervention: MRI/TRUS fusion-guided focal HIFU therapy., Outcome Measurements and Statistical Analysis: The primary outcome was the cancer-free rate of the HIFU-treated lesion by biopsy after 1 yr. Secondary endpoints included salvage treatment-free survival (STFS), metastasis-free survival (MFS), overall survival (OS), and PROMs according to International Consortium for Health Outcomes Measurement recommendations., Results and Limitations: Fifty patients were included (median [range] age 68 [48-80] yr; median PSA 6.5 [1.2-9.9] ng/ml; GG 1 54% [n = 27], and GG 2 46% [n = 23]). The median (range) PSA decrease from baseline to 12 mo was 51% (35.9-72.7%). In total, 37/50 patients (74%) underwent a 1-yr biopsy. PCa was detected in 23 patients (46%; GG 1 20% [n = 10]; GG >1 26% [n = 13]; infield 40% [n = 20]). At a median follow-up of 42 (13-73) mo, PCa was detected in 30 men (60%). Among all patients, 19 (38%) underwent salvage treatments (median [95% confidence interval] STFS 53 [44.3-61.7] mo). MFS and OS were 100% and 98%, respectively. The Expanded Prostate Cancer Index Composite-26 sexual domain decreased by 20.8 points (p = 0.372)., Conclusions: MRI/TRUS-guided focal HIFU therapy results in complete cancer ablation in only half of the treated patients after 1 yr, with further recurrences at medium-term follow-up. A decline of potency occurs in a subset of patients., Patient Summary: Focal image-guided high-intensity focused ultrasound therapy controls cancer in one of two patients. Its impact on urinary continence and erectile function is low., (Copyright © 2022 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Published: 2023
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195. GTF2I Mutation in Thymomas: Independence From Racial-Ethnic Backgrounds. An Indian/German Comparative Study.

Author: Jain D, Guleria P, Singh V, Parshad R, Kumar S, Gaiser T, Kurz KS, Ott G, Porubsky S, Preissler G, Sauer CG, Schölch S, Ströbel P, Hielscher T, Marx A, and Popovic ZV
Subjects: Adult, Aged, Female, Germany epidemiology, Humans, India epidemiology, Male, Middle Aged, Mutation, Myasthenia Gravis pathology, Race Factors, Thymoma epidemiology, Thymoma ethnology, Thymoma pathology, Thymus Neoplasms epidemiology, Thymus Neoplasms ethnology, Thymus Neoplasms pathology, Thymoma genetics, Thymus Neoplasms genetics, Transcription Factors, TFII genetics
Abstract: Thymomas are the most frequent adult mediastinal cancers. Their etiology is unknown and their pathogenesis poorly understood. Racial, ethnic and environmental factors influence tumorigenesis in many cancers, but their role in thymomas remains unclear to date. In this study that included pretreatment thymoma cases from India and Germany ( n = 37 and n = 77, respectively) we compared i) the prevalence of the thymoma-specific chromosome 7 c.74146970T > A mutation of the GTF2I gene in type A and AB thymomas; ii) epidemiological features; and iii) the frequency of myasthenia gravis (MG). Due to a known predominance of GTF2I mutation in A and AB histotypes, we included only a marginal number of type B thymomas as a control group in both cohorts. While the distribution of histological types between the cohorts was similar ( p = 0.1622), Indian patients were strikingly younger ( p < 0.0001; median age 50 vs. 65 years) and showed significantly lower tumour stage (Masaoka-Koga stage I) at primary diagnosis ( p = 0.0005) than the German patients. In patients with known MG status ( n = 17 in Indian and n = 25 in German cohort), a clear trend towards more frequent MG was observed in the Indian group ( p = 0.0504; 48 vs. 82%). The prevalence of the GTF2I mutation (analysed in n = 34 Indian and n = 77 German patients) was identical in the two cohorts. We conclude that racial-ethnic and environmental factors do not significantly influence the most common molecular feature of thymomas but may have an impact on the timing of clinical presentation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Jain, Guleria, Singh, Parshad, Kumar, Gaiser, Kurz, Ott, Porubsky, Preissler, Sauer, Schölch, Ströbel, Hielscher, Marx and Popovic.)
Published: 2021
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196. Molecular pathology of thymomas: implications for diagnosis and therapy.

Author: Marx A, Belharazem D, Lee DH, Popovic ZV, Reißfelder C, Schalke B, Schölch S, Ströbel P, Weis CA, and Yamada Y
Subjects: Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, DNA Mutational Analysis, Humans, Pathology, Molecular, Thymoma genetics, Thymoma metabolism, Thymoma pathology, Thymus Neoplasms genetics, Thymus Neoplasms metabolism, Thymus Neoplasms pathology, Mutation, Thymoma diagnosis, Thymus Neoplasms diagnosis
Abstract: Thymomas exhibit a unique genomic landscape, comprising the lowest on average total mutational burden among adult human cancers; a unique point mutation in the GTF2I gene in WHO type A and AB thymomas (and rarely others); almost unique KMT2A-MAML2 translocations in rare WHO type B2 and B3 thymomas; a unique YAP1-MAML2 translocation in almost all metaplastic thymomas; and unique miRNA profiles in relation to GTF2I mutational status and WHO histotypes. While most thymomas can be diagnosed solely on the basis of morphological features, mutational analyses can solve challenging differential diagnostic problems. No molecular biomarkers have been identified that predict the response of unresectable thymomas to chemotherapy or agents with known molecular targets. Despite the common and strong expression of PDL1 in thymomas, immune checkpoint inhibitors are rarely applicable due to the poor predictability of common, life-threatening autoimmune side effects that are related to the unrivaled propensity of thymomas towards autoimmunity.
Published: 2021
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197. Transcriptional profiling of dendritic cells matured in different osmolarities.

Author: Chessa F, Hielscher T, Mathow D, Gröne HJ, and Popovic ZV
Abstract: Tissue-specific microenvironments shape the fate of mononuclear phagocytes [1-3]. Interstitial osmolarity is a tissue biophysical parameter which considerably modulates the phenotype and function of dendritic cells [4]. In the present report we provide a detailed description of our experimental workflow and bioinformatic analysis applied to our gene expression dataset (GSE72174), aiming to investigate the influence of different osmolarity conditions on the gene expression signature of bone marrow-derived dendritic cells. We established a cell culture system involving murine bone marrow cells, cultured under different NaCl-induced osmolarity conditions in the presence of the dendritic cell growth factor GM-CSF. Gene expression analysis was applied to mature dendritic cells (day 7) developed in different osmolarities, with and without prior stimulation with the TLR2/4 ligand LPS.
Published: 2015
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198. Anti-inflammatory effects of alphav integrin antagonism in acute kidney allograft rejection.

Author: Bedke J, Kiss E, Behnes CL, Popovic ZV, Heuser M, Stojanovic T, Sijmonsma T, Huber P, Domhan S, Muschal S, Abdollahi A, Gretz N, and Gröne HJ
Subjects: Animals, Cell Adhesion drug effects, Cell Proliferation drug effects, Coculture Techniques, Fibroblasts drug effects, Graft Rejection pathology, Humans, Inflammation drug therapy, Integrin alphaV drug effects, Leukocyte Rolling drug effects, Leukocytes, Mononuclear drug effects, Macrophages drug effects, Male, Organic Chemicals pharmacology, Rats, Rats, Inbred Strains, Transplantation, Homologous, Graft Rejection prevention & control, Integrin alphaVbeta3 antagonists & inhibitors, Kidney Transplantation, Organic Chemicals therapeutic use
Abstract: Integrin-mediated cell adhesion and signaling is essential to vascular development and inflammatory processes. Elevated expression of integrin alpha(v)beta(3) has been detected in ischemia-reperfusion injury and rejecting heart allografts. We thus hypothesized that the inhibition of alpha(v)-associated integrins may have potent anti-inflammatory effects in acute kidney allograft rejection. We studied the effects of a peptidomimetic antagonist of alpha(v) integrins in two rat models of renal allotransplantation, differing in degree of major histocompatibility complex mismatch. Integrin alpha(v)beta(3) was up-regulated in rejecting renal allografts. Integrin antagonist reduced the histological signs of acute rejection, the intensity of the mononuclear cell infiltration, and cell proliferation in the grafted kidneys. This could be correlated to a reduced leukocyte-endothelial interaction and an improved peritubular microcirculation observed by intravital microscopy. In vitro under laminar flow conditions, the arrest of monocytes to interleukin-1beta-activated endothelium was decreased. Furthermore, in co-culture models the proliferation and transmigration of monocytes/macrophages, endothelium, and fibroblasts induced by renal tubular epithelia was efficiently inhibited by alpha(v) integrin antagonism. These data reveal an important role of this integrin subclass in leukocyte recruitment and development and maintenance of acute rejection; blockade of alpha(v) integrins may provide a new therapeutic strategy to attenuate acute allograft rejection.
Published: 2007
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