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151. Association of a CT-Based Clinical and Radiomics Score of Non-Small Cell Lung Cancer (NSCLC) with Lymph Node Status and Overall Survival

Author

Botta, Francesca, primary, Raimondi, Sara, additional, Rinaldi, Lisa, additional, Bellerba, Federica, additional, Corso, Federica, additional, Bagnardi, Vincenzo, additional, Origgi, Daniela, additional, Minelli, Rocco, additional, Pitoni, Giovanna, additional, Petrella, Francesco, additional, Spaggiari, Lorenzo, additional, Morganti, Alessio G., additional, Del Grande, Filippo, additional, Bellomi, Massimo, additional, and Rizzo, Stefania, additional

Published
2020
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152. Automated Large-Scale Production of Paclitaxel Loaded Mesenchymal Stromal Cells for Cell Therapy Applications

Author

Lisini, Daniela, primary, Nava, Sara, additional, Frigerio, Simona, additional, Pogliani, Simona, additional, Maronati, Guido, additional, Marcianti, Angela, additional, Coccè, Valentina, additional, Bondiolotti, Gianpietro, additional, Cavicchini, Loredana, additional, Paino, Francesca, additional, Petrella, Francesco, additional, Alessandri, Giulio, additional, Parati, Eugenio A., additional, and Pessina, Augusto, additional

Published
2020
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157. Preoperative mark and intraoperative view

Author

Petrella, Francesco, primary, Iacono, Giorgio Lo, additional, Casiraghi, Monica, additional, Gherzi, Lorenzo, additional, Prisciandaro, Elena, additional, Rampinelli, Cristiano, additional, Colandrea, Marzia, additional, Grana, Chiara Maria, additional, and Spaggiari, Lorenzo, additional

Published
2020
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164. Gare di appalto per le matrici acellulari dermiche: proposta per l’individuazione di score di qualità

Author

Magnoni, Cristina, Campitiello, Fernando, Papa, Giovanni, Scalise, Alessandro, Durante, Corrado, Petrella, Francesco, Magnoni, Cristina, Campitiello, Fernando, Papa, Giovanni, Scalise, Alessandro, Durante, Corrado, and Petrella, Francesco

Subjects
dermal substitutes
Abstract

I sostituti cutanei bioingegnerizzati sono una valida alternativa alle tecniche tradizionali di rigenerazione tissutale e vengono utilizzati sempre più frequentemente in interventi di ricostruzione di ferite sia acute che croniche

Published
2018

171. Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation

Author

Rizzo, Stefania, Rizzo, Stefania, Raimondi, Sara, de Jong, Evelyn E. C., van Elmpt, Wouter, De Piano, Francesca, Petrella, Francesco, Bagnardi, Vincenzo, Jochems, Arthur, Bellomi, Massimo, Dingemans, Anne Marie, Lambin, Philippe, Rizzo, Stefania, Rizzo, Stefania, Raimondi, Sara, de Jong, Evelyn E. C., van Elmpt, Wouter, De Piano, Francesca, Petrella, Francesco, Bagnardi, Vincenzo, Jochems, Arthur, Bellomi, Massimo, Dingemans, Anne Marie, and Lambin, Philippe

Abstract

Objective: To validate previously identified associations between radiological features and clinical features with Epidermal Growth Factor Receptor (EGER)/Kirsten RAt Sarcoma (KRAS) alterations in an independent group of patients with Non-Small Cell Lung Cancer (NSCLC).Material and methods: A total of 122 patients with NSCLC tested for EGFR/KRAS alterations were included. Clinical and radiological features were recorded.Univariate analysis were performed to look at the associations of the studied features with EGFR/KRAS alterations. Previously calculated composite model parameters for each gene alteration prediction were applied to this validation cohort. ROC (Receiver Operating Characteristic) curves were drawn using the previously validated composite models, and also for each significant individual characteristic of the previous training cohort model. The Area Under the ROC Curve (AUC) with 95% Confidence Intervals (CI) was calculated and compared between the full models.Results: At univariate analysis, EGFR + confirmed an association with an internal air bronchogram, pleural retraction, emphysema and lack of smoking; KRAS + with round shape, emphysema and smoking. The AUC (95%CI) in the new cohort was confirmed to be high for EGFR + prediction, with a value of: 0.82 (0.69-0.95) vs. 0.82 in the previous cohort, whereas it was smaller for KRAS + prediction, with a value of 0.60 (0.48-0.72) vs. 0.67 in the previous cohort. Looking at single features in the new cohort, we found that the AUC for the models including only smoking was similar to that of the full model (including radiological and clinical features) for both gene alterations.Conclusions: Although this study validated the significant association of clinical and radiological features with EGFR/KRAS alterations, models based on these composite features are not superior to smoking history alone to predict the mutations.

Published
2019

172. Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients—An external validation

Author

Rizzo, S, Raimondi, S, de Jong, E, van Elmpt, W, De Piano, F, Petrella, F, Bagnardi, V, Jochems, A, Bellomi, M, Dingemans, A, Lambin, P, Rizzo, Stefania, Raimondi, Sara, de Jong, Evelyn E. C., van Elmpt, Wouter, De Piano, Francesca, Petrella, Francesco, Bagnardi, Vincenzo, Jochems, Arthur, Bellomi, Massimo, Dingemans, Anne Marie, Lambin, Philippe, Rizzo, S, Raimondi, S, de Jong, E, van Elmpt, W, De Piano, F, Petrella, F, Bagnardi, V, Jochems, A, Bellomi, M, Dingemans, A, Lambin, P, Rizzo, Stefania, Raimondi, Sara, de Jong, Evelyn E. C., van Elmpt, Wouter, De Piano, Francesca, Petrella, Francesco, Bagnardi, Vincenzo, Jochems, Arthur, Bellomi, Massimo, Dingemans, Anne Marie, and Lambin, Philippe

Abstract

Objective: To validate previously identified associations between radiological features and clinical features with Epidermal Growth Factor Receptor (EGFR)/ Kirsten RAt Sarcoma (KRAS) alterations in an independent group of patients with Non-Small Cell Lung Cancer (NSCLC). Material and methods: A total of 122 patients with NSCLC tested for EGFR/KRAS alterations were included. Clinical and radiological features were recorded. Univariate analysis were performed to look at the associations of the studied features with EGFR/KRAS alterations. Previously calculated composite model parameters for each gene alteration prediction were applied to this validation cohort. ROC (Receiver Operating Characteristic) curves were drawn using the previously validated composite models, and also for each significant individual characteristic of the previous training cohort model. The Area Under the ROC Curve (AUC) with 95% Confidence Intervals (CI) was calculated and compared between the full models. Results: At univariate analysis, EGFR+ confirmed an association with an internal air bronchogram, pleural retraction, emphysema and lack of smoking; KRAS+ with round shape, emphysema and smoking. The AUC (95%CI) in the new cohort was confirmed to be high for EGFR+ prediction, with a value of: 0.82 (0.69-0.95) vs. 0.82 in the previous cohort, whereas it was smaller for KRAS+ prediction, with a value of 0.60 (0.48-0.72) vs. 0.67 in the previous cohort. Looking at single features in the new cohort, we found that the AUC for the models including only smoking was similar to that of the full model (including radiological and clinical features) for both gene alterations. Conclusions: Although this study validated the significant association of clinical and radiological features with EGFR/KRAS alterations, models based on these composite features are not superior to smoking history alone to predict the mutations.

Published
2019

181. Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients—An external validation

Author

Rizzo, Stefania, primary, Raimondi, Sara, additional, de Jong, Evelyn E.C., additional, van Elmpt, Wouter, additional, De Piano, Francesca, additional, Petrella, Francesco, additional, Bagnardi, Vincenzo, additional, Jochems, Arthur, additional, Bellomi, Massimo, additional, Dingemans, Anne Marie, additional, and Lambin, Philippe, additional

Published
2019
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183. Preliminary Results of Extracorporeal Membrane Oxygenation Assisted Tracheal Sleeve Pneumonectomy for Cancer.

Author

Spaggiari, Lorenzo, Sedda, Giulia, Petrella, Francesco, Venturino, Marco, Rossi, Fabiana, Guarize, Juliana, Galetta, Domenico, Casiraghi, Monica, Iacono, Giorgio Lo, Bertolaccini, Luca, and Alamanni, Francesco

Subjects
PNEUMONECTOMY, EXTRACORPOREAL membrane oxygenation, ONCOLOGIC surgery, BONE metastasis, LUNG cancer
Abstract

Objective Tracheal sleeve pneumonectomy is a challenge in lung cancer management and in achieving long-term oncological results. In November 2018, we started a prospective study on the role of extracorporeal membrane oxygenation (ECMO) in tracheal sleeve pneumonectomy. We aim to present our preliminary results. Methods From November 2018 to November 2019, six patients (three men and three women; median age: 61 years) were eligible for tracheal sleeve pneumonectomy for lung cancer employing the veno-venous ECMO during tracheobronchial anastomosis. Results Only in one patient, an intrapericardial pneumonectomy without ECMO support was performed, but cannulas were maintained during surgery. The median length of surgery was 201 minutes (range: 162–292 minutes), and the average duration of the apneic phase was 38 minutes (range: 31–45 minutes). No complications correlated to the positioning of the cannulas were recorded. There was only one major postoperative complication (hemothorax). At the time of follow-up, all patients were alive; one patient alive with bone metastasis was being treated with radiotherapy. Conclusion ECMO-assisted oncological surgery was rarely described, and its advantages include hemodynamic stability with low bleeding complications and a clean operating field. As suggested by our preliminary data, ECMO-assisted could be a useful alternative strategy in select lung cancer patients. [ABSTRACT FROM AUTHOR]

Published
2021
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186. EXPERIMENTAL AND CLINICAL AIRWAY RESTORATION BY MESENCHYMAL STROMAL CELLS AUTOLOGOUS ENDOSCOPIC TRANSPLANTATION

Author

Petrella, Francesco

Subjects
riparazione vie aeree/airway restoration, Settore MED/21 - Chirurgia Toracica, BIO/11 Biologia molecolare, MED/21 Chirurgia toracica, Settore BIO/11 - Biologia Molecolare, fistola broncopleurica/ bronchopleural fistula, mesenchymal stromal cell/cellula mesenchimale stromale, respiratory tract diseases
Abstract

Post resectional broncho-pleural fistula is a pathological connection between the airways and the pleural space that may develop after lung resection. It may be caused by incomplete bronchial closure, impediment of bronchial stump wound healing, or stump destruction by residual neoplastic tissue; its mortality ranges from 12.5 to 71.2%, therefore it is still the most feared complication after curative lung resection; for this reason the healing effects promoted by stem cells – by transformation into mature cells with a specialized function or by enhancing intrinsic repair mechanisms –may represent an effective and only partially explored therapeutic option . Mesenchymal stromal cells have the ability to migrate and engraft at sites of inflammation and injury in response to cytokines, chemokines, and growth factors at a wound site and they can exert local reparative effects through transdifferentiation into tissue-specific cell types or via the paracrine secretion of soluble factors with anti-inflammatory and wound-healing activities. We proposed, on an animal model, an autologous bone marrow derived mesenchymal stromal cells transplantation: it allowed bronchial stump healing by extraluminal fibroblast proliferation and collagenous matrix development. Encouraged by experimental bronchial wall restoration in large animals and by functional human organ replacement elsewhere, we undertook autologous bone marrow derived mesenchymal stromal cells bronchoscopic transplantation to treat a patient who developed broncho-pleural fistula. The bronchoscopic transplantation of bone marrow-derived mesenchymal stromal cells in our patient appeared to help close this small-caliber post resectional broncho-pleural fistula, further boosting regenerative medicine approach for airway diseases. Considering the need to specifically track mesenchymal stromal cells following transplantation in order to evaluate different method of implantation, to follow their migration within the body and to quantify their accumulation at the target, we proposed magnetic resonance imaging tracking both by superparamagnetic 6 iron oxide particles and perfluorocarbon nanoemulsion formulations , demonstrating that were both effective, without altering cell viability or differentiation. Finally we proposed adipose derived mesenchymal stromal cells bronchoscopic transplantation and intra venous injection of Granulocite Colony Stimulating Factors as a faster method and a new frontier in airway restoration.

Published
2017

187. Surgical Treatment of Bilateral Lung Cancers: Long-Term Outcomes and Prognostic Factors.

Author

Petrella, Francesco, Frassoni, Samuele, Bagnardi, Vincenzo, Casiraghi, Monica, Brambilla, Daniela, Diotti, Cristina, and Spaggiari, Lorenzo

Subjects
*LUNG cancer, *SURGICAL excision, *TUMOR classification, *SURGICAL complications, *METASTASIS
Abstract

Background Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease. The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes. Methods Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Preoperative patient characteristics were noted, including demographic information, operative details, pathologic information including histology and tumor stage according to the eighth edition of the tumor nodes metastases staging system, and the use of neoadjuvant or adjuvant treatments. Results Patients receiving the second pulmonary resection more than 24 months from the first procedure as well as patients receiving bilateral lobectomies had higher overall 3-, 5-, and 10-year survival rates compared with the others. Conclusion Patients receiving the second resection more than 24 months from the first procedure have the best long-term results irrespective of the type of resection. [ABSTRACT FROM AUTHOR]

Published
2020
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188. Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines

Author

Rimoldi, Isabella, primary, Coccè, Valentina, additional, Facchetti, Giorgio, additional, Alessandri, Giulio, additional, Brini, Anna Teresa, additional, Sisto, Francesca, additional, Parati, Eugenio, additional, Cavicchini, Loredana, additional, Lucchini, Giorgio, additional, Petrella, Francesco, additional, Ciusani, Emilio, additional, and Pessina, Augusto, additional

Published
2018
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198. Carinal resection: technical tips

Author

Casiraghi, Monica, primary, Mariolo, Alessio Vincenzo, additional, Galetta, Domenico, additional, Petrella, Francesco, additional, Brambilla, Daniela, additional, and Spaggiari, Lorenzo, additional

Published
2018
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