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The article suggests an overall review of modern technological trends in education. The authors aimed to figure out the objectives, benefits and obstacles of their development. The article deals with innovations, which have already been and are being implemented in education system with Industry 5.0 shortly ahead. The main aim is to determine social and cultural impact of rapid digitalization in the sphere of education. Research methods were based on deductive categories. Elements of descriptive and comparative analysis were applied for identification of major patterns and tendencies. The review given by the authors proves that education is one of the main challenges for authorities, teachers and students in terms of digitalization. The results of the research indicate the importance of new paradigm and reconsidering of educational environment in general. It involves technological, social and communicative aspects. Some conventional standards have become obsolete and we need to acknowledge the fact. Modern society is facing not only technological challenges but also the ones concerning attitude and skills. We can conclude that effective agreement between social and technological process can be reached if legal framework and standardized approaches are involved.

Objectives to assess the features of the inflammatory process of the nasal mucous membrane and sinuses in patients with сhronic rhinosinusitis with nasal polyps (CRSwNP). Material and methods. We analyzed the results of examination of 44 patients with CRSwNP. The objects of investigation were smears-reprints from the mucous membrane of the middle turbinate (rhinocytograms) and the intensity of the extracellular peroxidase activity of the lavage fluids of the maxillary sinuses. The data obtained were processed using the Statistica 8.0 software. Results. When analyzing rhinocytograms of the mucous membrane of the middle turbinates, the epithelial type of rhinocytogram was most often detected in 65.9% of cases (epithelial cells more than 50%); the eosinophilic type in 22.7% (eosinophils more than 1%) and smears with mast cells in 4.6% of cases; the neutrophilic type was less frequent (neutrophils more than 50%) 6.8% of cases. In 34.1% of patients, the cells of the columnar epithelium had pronounced changes in the cytoplasm (vacuolization and enzymatic activity); and in 38.6% of cases the gross pathology was recorded directly in the nucleus of the cells (nucleoli, granules, destruction of the nucleus). The revealed pathology of the cell nucleus suggests the viral etiology of the development of productive inflammation in the nasal cavity and sinuses In the lavage fluids of the maxillary sinuses, a high intensity of extracellular peroxidase activity was recorded (1777.9132.4 a.u. compared to 1225.0190.9 a.u. in patients with chronic purulent rhinosinusitis and 1245.0362.3 a.u. in patients with purulent-polypous rhinosinusitis). Conclusion. Chronic rhinosinusitis with nasal polyps is accompanied by a pronounced inflammatory process of the nasal mucous membrane and paranasal sinuses in the form of structural and functional changes in the cells of the columnar epithelium and a high intensity of extracellular peroxidase activity. The epithelial nucleus damage (the presence of nucleoli, granules, destruction of the nucleus) suggests a viral nature with the development of productive inflammation in the nasal cavity and sinuses.

The paper presents a comparative analysis of the reaction of different consumer groups to the bank credit supply shocks. As parameters of consumer heterogeneity, we consider differences ( i ) in the form of home ownership (households with and without mortgages and tenants) and ( ii ) in the form of credit (households with large debt (mortgages, car loans), households with small (consumer) credit and without loans). For empirical analysis we use RLMS-HSE longitudinal Household Panel Survey for the period from 2006 to 2019, which covers two episodes of the credit crisis and post-crisis recovery. Bank credit supply shocks are estimated using the standard structural vector autoregression (SVAR) model, which also identifies aggregate supply and demand shocks and monetary policy shocks. Our results show that with a positive credit supply shock, which is equivalent to a 0.5 percentage point reduction in the interest rate on loans, households with mortgages increase their consumption by 2.1—2.5% more than households without mortgages. The observed effect is significant, since the average annual growth rate of consumption of households with mortgages in our sample is 3.8%. Our results indicate that the Bank of Russia’s macroprudential policy, which uses countercyclical capital buffers (Basel III) as a tool, can be very effective in smoothing the consumption of households with mortgage debt.

Hepatitis C virus mRNA contains an internal ribosome entry site (IRES) that mediates end-independent translation initiation, requiring a subset of eukaryotic initiation factors (eIFs). Biochemical studies revealed that direct binding of the IRES to the 40S ribosomal subunit places the initiation codon into the P site, where it base pairs with eIF2-bound Met-tRNAiMet forming a 48S initiation complex. Subsequently, eIF5 and eIF5B mediate subunit joining, yielding an elongation-competent 80S ribosome. Initiation can also proceed without eIF2, in which case Met-tRNAiMet is recruited directly by eIF5B. However, the structures of initiation complexes assembled on the HCV IRES, the transitions between different states, and the accompanying conformational changes have remained unknown. To fill these gaps, we now obtained cryo-EM structures of IRES initiation complexes, at resolutions up to 3.5 Å, that cover all major stages from the initial ribosomal association, through eIF2-containing 48S initiation complexes, to eIF5B-containing complexes immediately prior to subunit joining. These structures provide insights into the dynamic network of 40S/IRES contacts, highlight the role of IRES domain II, and reveal conformational changes that occur during the transition from eIF2- to eIF5B-containing 48S complexes and prepare them for subunit joining.

In the conditions of an increasing information flow and multichannel sources of access to information, the teacher is increasingly losing the monopoly that existed until recently on opening knowledge to students, and at the same time, the position of the leader-organizer of the educational process assigned to him automatically disappears into the past. Thus, the research task of substantiating effective mechanisms for restoring the active position of a teacher, but already in the formation of information and communicative competence of students in accordance with the new situation that has arisen in modern education, is urgent. We consider the formation of creative leadership as a necessary component in the structure of his professional and pedagogical competence to be among the effective mechanisms that ensure the modern teacher's readiness to implement new functions in the educational process. The article examines the evolution of the conceptualization of the phenomenon of leadership in the studies of Russian authors, clarifies the concept of leadership in education, establishes its functions in the educational process in order to determine the pedagogical conditions for the formation of a teacher's readiness to implement new functions in the modern educational process. This article describes the evolution of the conceptualization of the phenomenon of leadership in domestic research within the framework of the theory of small groups or collectives, the tradition of studying which is rooted in the works of Russian authors of the 20th century. At the beginning of the 20th century, the phenomenon of leadership was considered by domestic scientists within the framework of the problem of the relationship between individual and group problem solving, as a phenomenon of social power in a team, as well as within the framework of the problem of "children's leadership", in the modern interpretation - leadership. The problems of organizational activity and organizational skills, management and leadership, the effectiveness of a small group and the psychological climate as a factor of effective interaction in a small group were actively studied. At the end of the 20th century, in the works of domestic researchers studying the phenomenon of leadership, the idea of differentiating business and emotional leadership is being developed, the role of the leader-generator of ideas and the leader-motivator is highlighted, that is, there is a tendency to bring to the fore the value foundations of leadership, ethics and morality. However, according to Russian scientists at the beginning of the 21st century, the study of the phenomenon of leadership in domestic research lags behind the demands of social practice, including in education, and the idea of the advisability of including leadership among the key professional competencies of a teacher is being formulated. At the same time, the essence of this concept is significantly clarified and, following the authors of foreign studies, is interpreted in a new capacity as “creative leadership”, as the position of a motivator for the process of forming students' readiness to realize their creative potential.

The article is devoted to the issues related to the study of the process of identification and professional self-organization of public relations specialists in the Far-Eastern region of Russia. This process is studied from the point of view of defining the group identity, group norms, and the activities of professional communities. The empirical basis of analysis was the results of an expert survey of public relations specialists in the Far-Eastern federal district. The authors identify the current professional PR communities of the Russian Far East, identify the motives of their members for more active participation in the communities life. There is an independent association of representatives of professional group due to the grassroots activity «spontaneous self-organization» and the presence of experience in consolidating PR specialists in a specific field (state) with an external actor. It is concluded that today there is a willingness of the self-organized PR community to participate in solving the socially significant issues for the region, the development of inter-sector partnership, as a result of formation of trusting attitude of population to the decisions taken in the region.