234,837 results on '"Pearson AN"'
Search Results
152. Environmental health of wildland firefighters: a scoping review
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Held, M. Bryan, Ragland, Miranda Rose, Wood, Sage, Pearson, Amelia, Pearson, Seth Wayne, Chenevert, Olivia, Granberg, Rachel Marie, and Verble, Robin Michelle
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- 2024
- Full Text
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153. Inaugural Federation University Annual Reconciliation Lecture
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Pearson, Noel
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- 2023
154. Characterization and Diversification of AraC/XylS Family Regulators Guided by Transposon Sequencing
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Pearson, Allison N, Incha, Matthew R, Ho, Cindy N, Schmidt, Matthias, Roberts, Jacob B, Nava, Alberto A, and Keasling, Jay D
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Biochemistry and Cell Biology ,Bioinformatics and Computational Biology ,Biological Sciences ,Genetics ,Escherichia coli ,Bacterial Proteins ,Promoter Regions ,Genetic ,Pseudomonas putida ,Plasmids ,Gene Expression Regulation ,Bacterial ,Escherichia coli Proteins ,AraC Transcription Factor ,Medicinal and Biomolecular Chemistry ,Biomedical Engineering ,Biochemistry and cell biology ,Bioinformatics and computational biology - Abstract
In this study, we explored the development of engineered inducible systems. Publicly available data from previous transposon sequencing assays were used to identify regulators of metabolism in Pseudomonas putida KT2440. For AraC family regulators (AFRs) represented in these data, we posited AFR/promoter/inducer groupings. Twelve promoters were characterized for a response to their proposed inducers in P. putida, and the resultant data were used to create and test nine two-plasmid sensor systems in Escherichia coli. Several of these were further developed into a palette of single-plasmid inducible systems. From these experiments, we observed an unreported inducer response from a previously characterized AFR, demonstrated that the addition of a P. putida transporter improved the sensor dynamics of an AFR in E. coli, and identified an uncharacterized AFR with a novel potential inducer specificity. Finally, targeted mutations in an AFR, informed by structural predictions, enabled the further diversification of these inducible plasmids.
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- 2024
155. The selection landscape and genetic legacy of ancient Eurasians
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Irving-Pease, Evan K, Refoyo-Martínez, Alba, Barrie, William, Ingason, Andrés, Pearson, Alice, Fischer, Anders, Sjögren, Karl-Göran, Halgren, Alma S, Macleod, Ruairidh, Demeter, Fabrice, Henriksen, Rasmus A, Vimala, Tharsika, McColl, Hugh, Vaughn, Andrew H, Speidel, Leo, Stern, Aaron J, Scorrano, Gabriele, Ramsøe, Abigail, Schork, Andrew J, Rosengren, Anders, Zhao, Lei, Kristiansen, Kristian, Iversen, Astrid KN, Fugger, Lars, Sudmant, Peter H, Lawson, Daniel J, Durbin, Richard, Korneliussen, Thorfinn, Werge, Thomas, Allentoft, Morten E, Sikora, Martin, Nielsen, Rasmus, Racimo, Fernando, and Willerslev, Eske
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Biological Sciences ,Genetics ,History ,Heritage and Archaeology ,Human Society ,Archaeology ,Historical Studies ,Anthropology ,Good Health and Well Being ,Humans ,Alzheimer Disease ,Affect ,Alleles ,Agriculture ,Europe ,General Science & Technology - Abstract
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, whereas risk alleles for diabetes and Alzheimer's disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.
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- 2024
156. Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
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Barrie, William, Yang, Yaoling, Irving-Pease, Evan K, Attfield, Kathrine E, Scorrano, Gabriele, Jensen, Lise Torp, Armen, Angelos P, Dimopoulos, Evangelos Antonios, Stern, Aaron, Refoyo-Martinez, Alba, Pearson, Alice, Ramsøe, Abigail, Gaunitz, Charleen, Demeter, Fabrice, Jørkov, Marie Louise S, Møller, Stig Bermann, Springborg, Bente, Klassen, Lutz, Hyldgård, Inger Marie, Wickmann, Niels, Vinner, Lasse, Korneliussen, Thorfinn Sand, Allentoft, Morten E, Sikora, Martin, Kristiansen, Kristian, Rodriguez, Santiago, Nielsen, Rasmus, Iversen, Astrid KN, Lawson, Daniel J, Fugger, Lars, and Willerslev, Eske
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Biological Sciences ,Genetics ,History ,Heritage and Archaeology ,Archaeology ,Historical Studies ,Neurosciences ,Autoimmune Disease ,Multiple Sclerosis ,Brain Disorders ,Neurodegenerative ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Neurological ,Humans ,Neurodegenerative Diseases ,Cluster Analysis ,Population Density ,Child ,Preschool ,Europe ,General Science & Technology - Abstract
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.
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- 2024
157. 100 ancient genomes show repeated population turnovers in Neolithic Denmark
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Allentoft, Morten E, Sikora, Martin, Fischer, Anders, Sjögren, Karl-Göran, Ingason, Andrés, Macleod, Ruairidh, Rosengren, Anders, Schulz Paulsson, Bettina, Jørkov, Marie Louise Schjellerup, Novosolov, Maria, Stenderup, Jesper, Price, T Douglas, Fischer Mortensen, Morten, Nielsen, Anne Birgitte, Ulfeldt Hede, Mikkel, Sørensen, Lasse, Nielsen, Poul Otto, Rasmussen, Peter, Jensen, Theis Zetner Trolle, Refoyo-Martínez, Alba, Irving-Pease, Evan K, Barrie, William, Pearson, Alice, Sousa da Mota, Bárbara, Demeter, Fabrice, Henriksen, Rasmus A, Vimala, Tharsika, McColl, Hugh, Vaughn, Andrew, Vinner, Lasse, Renaud, Gabriel, Stern, Aaron, Johannsen, Niels Nørkjær, Ramsøe, Abigail Daisy, Schork, Andrew Joseph, Ruter, Anthony, Gotfredsen, Anne Birgitte, Henning Nielsen, Bjarne, Brinch Petersen, Erik, Kannegaard, Esben, Hansen, Jesper, Buck Pedersen, Kristoffer, Pedersen, Lisbeth, Klassen, Lutz, Meldgaard, Morten, Johansen, Morten, Uldum, Otto Christian, Lotz, Per, Lysdahl, Per, Bangsgaard, Pernille, Petersen, Peter Vang, Maring, Rikke, Iversen, Rune, Wåhlin, Sidsel, Anker Sørensen, Søren, Andersen, Søren H, Jørgensen, Thomas, Lynnerup, Niels, Lawson, Daniel J, Rasmussen, Simon, Korneliussen, Thorfinn Sand, Kjær, Kurt H, Durbin, Richard, Nielsen, Rasmus, Delaneau, Olivier, Werge, Thomas, Kristiansen, Kristian, and Willerslev, Eske
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Biological Sciences ,Genetics ,History ,Heritage and Archaeology ,Human Society ,Archaeology ,Historical Studies ,Anthropology ,Humans ,Genomics ,Genotype ,Denmark ,Emigrants and Immigrants ,Scandinavians and Nordic People ,General Science & Technology - Abstract
Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1-4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5-7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
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- 2024
158. Population genomics of post-glacial western Eurasia
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Allentoft, Morten E, Sikora, Martin, Refoyo-Martínez, Alba, Irving-Pease, Evan K, Fischer, Anders, Barrie, William, Ingason, Andrés, Stenderup, Jesper, Sjögren, Karl-Göran, Pearson, Alice, Sousa da Mota, Bárbara, Schulz Paulsson, Bettina, Halgren, Alma, Macleod, Ruairidh, Jørkov, Marie Louise Schjellerup, Demeter, Fabrice, Sørensen, Lasse, Nielsen, Poul Otto, Henriksen, Rasmus A, Vimala, Tharsika, McColl, Hugh, Margaryan, Ashot, Ilardo, Melissa, Vaughn, Andrew, Fischer Mortensen, Morten, Nielsen, Anne Birgitte, Ulfeldt Hede, Mikkel, Johannsen, Niels Nørkjær, Rasmussen, Peter, Vinner, Lasse, Renaud, Gabriel, Stern, Aaron, Jensen, Theis Zetner Trolle, Scorrano, Gabriele, Schroeder, Hannes, Lysdahl, Per, Ramsøe, Abigail Daisy, Skorobogatov, Andrei, Schork, Andrew Joseph, Rosengren, Anders, Ruter, Anthony, Outram, Alan, Timoshenko, Aleksey A, Buzhilova, Alexandra, Coppa, Alfredo, Zubova, Alisa, Silva, Ana Maria, Hansen, Anders J, Gromov, Andrey, Logvin, Andrey, Gotfredsen, Anne Birgitte, Henning Nielsen, Bjarne, González-Rabanal, Borja, Lalueza-Fox, Carles, McKenzie, Catriona J, Gaunitz, Charleen, Blasco, Concepción, Liesau, Corina, Martinez-Labarga, Cristina, Pozdnyakov, Dmitri V, Cuenca-Solana, David, Lordkipanidze, David O, En’shin, Dmitri, Salazar-García, Domingo C, Price, T Douglas, Borić, Dušan, Kostyleva, Elena, Veselovskaya, Elizaveta V, Usmanova, Emma R, Cappellini, Enrico, Brinch Petersen, Erik, Kannegaard, Esben, Radina, Francesca, Eylem Yediay, Fulya, Duday, Henri, Gutiérrez-Zugasti, Igor, Merts, Ilya, Potekhina, Inna, Shevnina, Irina, Altinkaya, Isin, Guilaine, Jean, Hansen, Jesper, Aura Tortosa, Joan Emili, Zilhão, João, Vega, Jorge, Buck Pedersen, Kristoffer, Tunia, Krzysztof, Zhao, Lei, Mylnikova, Liudmila N, Larsson, Lars, Metz, Laure, Yepiskoposyan, Levon, Pedersen, Lisbeth, Sarti, Lucia, Orlando, Ludovic, Slimak, Ludovic, Klassen, Lutz, Blank, Malou, González-Morales, Manuel, and Silvestrini, Mara
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Biological Sciences ,Genetics ,History ,Heritage and Archaeology ,Human Society ,Historical Studies ,Anthropology ,Biotechnology ,Humans ,Genomics ,Diploidy ,Agriculture ,Europe ,Metagenomics ,General Science & Technology - Abstract
Western Eurasia witnessed several large-scale human migrations during the Holocene1-5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a 'Neolithic steppe' cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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- 2024
159. Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk.
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Garrison-Desany, Henri, Meyers, Jacquelyn, Linnstaedt, Sarah, House, Stacey, Beaudoin, Francesca, An, Xinming, Zeng, Donglin, Neylan, Thomas, Clifford, Gari, Jovanovic, Tanja, Germine, Laura, Bollen, Kenneth, Rauch, Scott, Haran, John, Storrow, Alan, Lewandowski, Christopher, Musey, Paul, Hendry, Phyllis, Sheikh, Sophia, Jones, Christopher, Punches, Brittany, Swor, Robert, Gentile, Nina, Hudak, Lauren, Pascual, Jose, Seamon, Mark, Harris, Erica, Pearson, Claire, Peak, David, Domeier, Robert, Rathlev, Niels, ONeil, Brian, Sergot, Paulina, Sanchez, Leon, Bruce, Steven, Joormann, Jutta, Harte, Steven, McLean, Samuel, Koenen, Karestan, and Denckla, Christy
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alcohol ,cannabis ,causal forest ,effect modification ,post-traumatic stress disorder ,socioenvironmental factors ,substance use ,tobacco - Abstract
BACKGROUND: Post-traumatic stress disorder (PTSD) and substance use (tobacco, alcohol, and cannabis) are highly comorbid. Many factors affect this relationship, including sociodemographic and psychosocial characteristics, other prior traumas, and physical health. However, few prior studies have investigated this prospectively, examining new substance use and the extent to which a wide range of factors may modify the relationship to PTSD. METHODS: The Advancing Understanding of RecOvery afteR traumA (AURORA) study is a prospective cohort of adults presenting at emergency departments (N = 2,943). Participants self-reported PTSD symptoms and the frequency and quantity of tobacco, alcohol, and cannabis use at six total timepoints. We assessed the associations of PTSD and future substance use, lagged by one timepoint, using the Poisson generalized estimating equations. We also stratified by incident and prevalent substance use and generated causal forests to identify the most important effect modifiers of this relationship out of 128 potential variables. RESULTS: At baseline, 37.3% (N = 1,099) of participants reported likely PTSD. PTSD was associated with tobacco frequency (incidence rate ratio (IRR): 1.003, 95% CI: 1.00, 1.01, p = 0.02) and quantity (IRR: 1.01, 95% CI: 1.001, 1.01, p = 0.01), and alcohol frequency (IRR: 1.002, 95% CI: 1.00, 1.004, p = 0.03) and quantity (IRR: 1.003, 95% CI: 1.001, 1.01, p = 0.001), but not with cannabis use. There were slight differences in incident compared to prevalent tobacco frequency and quantity of use; prevalent tobacco frequency and quantity were associated with PTSD symptoms, while incident tobacco frequency and quantity were not. Using causal forests, lifetime worst use of cigarettes, overall self-rated physical health, and prior childhood trauma were major moderators of the relationship between PTSD symptoms and the three substances investigated. CONCLUSION: PTSD symptoms were highly associated with tobacco and alcohol use, while the association with prospective cannabis use is not clear. Findings suggest that understanding the different risk stratification that occurs can aid in tailoring interventions to populations at greatest risk to best mitigate the comorbidity between PTSD symptoms and future substance use outcomes. We demonstrate that this is particularly salient for tobacco use and, to some extent, alcohol use, while cannabis is less likely to be impacted by PTSD symptoms across the strata.
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- 2024
160. Past and future climate effects on population structure and diversity of North Pacific surfgrasses
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Tavares, Ana I, Assis, Jorge, Anderson, Laura, Raimondi, Pete, Coelho, Nelson Castilho, Paulino, Cristina, Ladah, Lydia, Nakaoka, Masahiro, Pearson, Gareth A, and Serrao, Ester A
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Biological Sciences ,Ecology ,Evolutionary Biology ,Genetics ,Climate Action ,climate change ,genetic diversity ,marine biogeography ,range shifts ,SDMs ,seagrasses ,Earth Sciences ,Environmental Sciences ,Biological sciences ,Earth sciences ,Environmental sciences - Abstract
Abstract: Aim: Understanding the impacts of past and future climate change on genetic diversity and structure is a current major research gap. We ask whether past range shifts explain the observed genetic diversity of surfgrass species and if future climate change projections anticipate genetic diversity losses. Our study aims to identify regions of long‐term climate suitability with higher and unique seagrass genetic diversity and predict future impacts of climate change on them. Location: Northeast Pacific. Time Period: Analyses considered a timeframe from the Last Glacial Maximum (LGM; 20 kybp) until one Representative Concentration Pathway (RCP) scenario of future climate changes (RCP 8.5; 2100). Major Taxa Studied: Two seagrass species belonging to the genus Phyllospadix. Methods: We estimated population genetic diversity and structure using 11 polymorphic microsatellite markers. We predicted the distribution of the species for the present, LGM, and near future (RCP 8.5, no climate mitigation) using Species Distribution Models (SDMs). Results: SDMs revealed southward range shifts during the LGM and potential poleward expansions in the future. Genetic diversity of Phyllospadix torreyi decreases from north to south, but in Phyllospadix scouleri the trend is variable. Phyllospadix scouleri displays signals of genome admixture at the southernmost and northernmost edges of its distribution. Main Conclusions: The genetic patterns observed in the present reveal the influence of climate‐driven range shifts in the past and suggest further consequences of climate change in the future, with potential loss of unique gene pools. This study also shows that investigating climate links to present genetic information at multiple timescales can establish a historical context for analyses of the future evolutionary history of populations.
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- 2024
161. Trans-Arctic asymmetries, melting pots and weak species cohesion in the low-dispersal amphiboreal seaweed Fucus distichus
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Neiva, João, Assis, Jorge, Fragkopoulou, Eliza, Pearson, Gareth A, Raimondi, Peter T, Anderson, Laura, Krause-Jensen, Dorte, Marbà, Núria, Want, Andrew, Selivanova, Olga, Nakaoka, Masahiro, Grant, W Stewart, Konar, Brenda, Roleda, Michael Y, Sejr, Mikael K, Paulino, Cristina, and Serrão, Ester A
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Biological Sciences ,Ecology ,Evolutionary Biology ,Genetics ,intertidal ,climate-driven range shifts ,cryptic species ,functional bottleneck ,genetic hotspots and melting pots ,niche unfilling ,trans-Arctic phylogeography ,Evolutionary biology ,Ecological applications - Abstract
Amphiboreal taxa are often composed of vicariant phylogroups and species complexes whose divergence and phylogeographic affinities reflect a shared history of chronic isolation and episodic trans-Arctic dispersal. Ecological filters and shifting selective pressures may also promote selective sweeps, niche shifts and ecological speciation during colonization, but these are seldom considered at biogeographical scales. Here we integrate genetic data and Ecologic Niche Models (ENMs) to investigate the historical biogeography and cohesion of the polymorphic rockweed Fucus distichus throughout its immense amphiboreal range, focusing on trans-Arctic asymmetries, glacial/interglacial dynamics, and integrity of sympatric eco-morphotypes. Populations were sampled throughout the Pacific and the Atlantic, from southern rear-edges to the high-Arctic. They were genotyped for seven microsatellites and an mtDNA spacer, and genetic diversity and structure were assessed from global to local scales. ENMs were used to compare niche divergence and magnitude of post-glacial range shifts in Pacific versus Atlantic sub-ranges. Haplotypic and genotypic data revealed distinct and seemingly isolated Pacific vs Arctic/Atlantic gene-pools, with finer-scale regional sub-structuring pervasive in the Pacific. MtDNA diversity was highly structured and overwhelmingly concentrated in the Pacific. Regionally, Alaska showed the highest intra-population diversity but the lowest levels of endemism. Some sympatric/parapatric ecotypes exhibited distinct genotypic/haplotypic compositions. Strikingly, niche models revealed higher Pacific tolerance to maximum temperatures and predicted a much more consolidated presence in the NE Atlantic. Glacial and modern ranges overlapped extensively in the Pacific, whereas the modern Atlantic range was largely glaciated or emerged during the Last Glacial Maximum. Higher genetic and ecogeographic diversity supports a primary Pacific diversification and secondary Atlantic colonization, also likely reflecting the much larger and more stable climatic refugia in the Pacific. The relic distribution and reduced ecological/morphological plasticity in the NE Atlantic are hypothesized to reflect functional trans-Arctic bottlenecks, recent colonization or competition with congeners. Within the Pacific, Alaska showed signatures of a post-glacial melting pot of eastern and southern populations. Genetic/ecotypic variation was generally not sufficiently discontinuous or consistent to justify recognizing multiple taxonomic entities, but support a separate species in the eastern Pacific, at the southern rear-edge. We predict that layered patterns of phylogeographic structure, incipient speciation and niche differences might be common among widespread low-dispersal amphiboreal taxa.
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- 2024
162. Towards a movement science of communication
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Kadavà, ≈†àrka, Pearson, Lara, Trujillo, James, and Pouw, Wim
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Cognitive Neuroscience ,Linguistics ,Psychology ,Action ,Animal Communication ,Behavioral Science ,Complex systems ,Embodied Cognition ,Language Production ,Situated cognition ,Gesture analysis - Abstract
To communicate is to move. There is no way around that. Ifwe pick up comprehensive handbooks or introductory textsin movement science (Hong and Bartlett (2008)) we seethat there is very rich knowledge and tractable mathematicalmodels about different aspects of movements. Yet, we findno chapter on communicative movements. While the fieldof speech motor control is a developed area on its own(Parrell and Lammert (2019)), there is no movement scienceof communication proper, which would include whole-body-,hand-gestural-, signed-, and inter-bodily actions.
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- 2024
163. Optimal decision-making under task uncertainty: a computational basis for cognitive stability versus flexibility
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Madlon-Kay, Seth, Pearson, John, and Egner, Tobias
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Cognitive Neuroscience ,Attention ,Decision making ,Computational Modeling - Abstract
Cognitive control is thought to regulate the conflict between stability---maintaining the current task in the face of distraction---and flexibility---switching to a new task of greater priority. However, evidence conflicts regarding when and to what extent stability and flexibility trade-off. A normative theory of flexibility and stability may help clarify when and why we should expect such trade-offs to occur. Towards such a theory, we model task-switching as a problem of decision-making under uncertainty, in which the decision-maker must simultaneously infer both the identity of a stimulus and the task governing the correct response to that stimulus. We find that optimal behavior is either extremely stable or extremely flexible, but not both, indicating a normative basis for a trade-off between the two. However, we also show that a sub-optimal but more realistic decision-maker exhibits behavior between these two extremes, and more closely resembles experimental data.
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- 2024
164. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
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Everman, Jamie L, Sajuthi, Satria P, Liegeois, Maude A, Jackson, Nathan D, Collet, Erik H, Peters, Michael C, Chioccioli, Maurizio, Moore, Camille M, Patel, Bhavika B, Dyjack, Nathan, Powell, Roger, Rios, Cydney, Montgomery, Michael T, Eng, Celeste, Elhawary, Jennifer R, Mak, Angel CY, Hu, Donglei, Huntsman, Scott, Salazar, Sandra, Feriani, Luigi, Fairbanks-Mahnke, Ana, Zinnen, Gianna L, Michel, Cole R, Gomez, Joe, Zhang, Xing, Medina, Vivian, Chu, Hong Wei, Cicuta, Pietro, Gordon, Erin D, Zeitlin, Pamela, Ortega, Victor E, Reisdorph, Nichole, Dunican, Eleanor M, Tang, Monica, Elicker, Brett M, Henry, Travis S, Bleecker, Eugene R, Castro, Mario, Erzurum, Serpil C, Israel, Elliot, Levy, Bruce D, Mauger, David T, Meyers, Deborah A, Sumino, Kaharu, Gierada, David S, Hastie, Annette T, Moore, Wendy C, Denlinger, Loren C, Jarjour, Nizar N, Schiebler, Mark L, Wenzel, Sally E, Woodruff, Prescott G, Rodriguez-Santana, Jose, Pearson, Chad G, Burchard, Esteban G, Fahy, John V, and Seibold, Max A
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Asthma ,Lung ,Genetics ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Respiratory ,Child ,Humans ,Cytokines ,Epithelial Cells ,GPI-Linked Proteins ,Interleukin-13 ,Lectins ,Mucin 5AC ,Mucus ,Nasal Mucosa ,Polymorphism ,Genetic ,Respiratory Mucosa - Abstract
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC+ mucus secretory cells, and that ITLN-1 protein is a secreted component of IL-13-induced mucus. Additionally, we find ITLN-1 protein binds the C-terminus of the MUC5AC mucin and that its deletion in airway epithelial cells partially reverses IL-13-induced mucostasis. Through analysis of nasal airway epithelial brushings, we find that ITLN1 is highly expressed in T2-high asthmatics, when compared to T2-low children. Furthermore, we demonstrate that both ITLN-1 gene expression and protein levels are significantly reduced by a common genetic variant that is associated with protection from the formation of mucus plugs in T2-high asthma. This work identifies an important biomarker and targetable pathways for the treatment of mucus obstruction in asthma.
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- 2024
165. Development of Corynebacterium glutamicum as a monoterpene production platform
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Luckie, Bridget A, Kashyap, Meera, Pearson, Allison N, Chen, Yan, Liu, Yuzhong, Valencia, Luis E, Carrillo Romero, Alexander, Hudson, Graham A, Tao, Xavier B, Wu, Bryan, Petzold, Christopher J, and Keasling, Jay D
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Biological Sciences ,Industrial Biotechnology ,Monoterpenes ,Corynebacterium glutamicum ,Mevalonic Acid ,Terpenes ,Metabolic Engineering ,Monoterpene biosynthetic production ,Geraniol ,Citronellol ,Eucalyptol ,Linalool ,Citral ,Citronellic acid ,Biotechnology ,Biochemistry and cell biology ,Industrial biotechnology - Abstract
Monoterpenes are commonly known for their role in the flavors and fragrances industry and are also gaining attention for other uses like insect repellant and as potential renewable fuels for aviation. Corynebacterium glutamicum, a Generally Recognized as Safe microbe, has been a choice organism in industry for the annual million ton-scale bioproduction of amino acids for more than 50 years; however, efforts to produce monoterpenes in C. glutamicum have remained relatively limited. In this study, we report a further expansion of the C. glutamicum biosynthetic repertoire through the development and optimization of a mevalonate-based monoterpene platform. In the course of our plasmid design iterations, we increased flux through the mevalonate-based bypass pathway, measuring isoprenol production as a proxy for monoterpene precursor abundance and demonstrating the highest reported titers in C. glutamicum to date at 1504.6 mg/L. Our designs also evaluated the effects of backbone, promoter, and GPP synthase homolog origin on monoterpene product titers. Monoterpene production was further improved by disrupting competing pathways for isoprenoid precursor supply and by implementing a biphasic production system to prevent volatilization. With this platform, we achieved 321.1 mg/L of geranoids, 723.6 mg/L of 1,8-cineole, and 227.8 mg/L of linalool. Furthermore, we determined that C. glutamicum first oxidizes geraniol through an aldehyde intermediate before it is asymmetrically reduced to citronellol. Additionally, we demonstrate that the aldehyde reductase, AdhC, possesses additional substrate promiscuity for acyclic monoterpene aldehydes.
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- 2024
166. Hypoxemic Respiratory Failure and Coccidioidomycosis-Associated Acute Respiratory Distress Syndrome
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Heidari, Arash, Kaur, Simmer, Pearson, Skyler J, Munoz, Augustine, Sandhu, Harleen, Mann, Gursimran, Schivo, Michael, Zeki, Amir A, Bays, Derek J, Wilson, Machelle, Albertson, Timothy E, Johnson, Royce, and Thompson, George R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Acute Respiratory Distress Syndrome ,Clinical Trials and Supportive Activities ,Orphan Drug ,Rare Diseases ,Clinical Research ,Lung ,Infectious Diseases ,2.4 Surveillance and distribution ,Respiratory ,Good Health and Well Being ,ARDS ,Coccidioides ,fungal pneumonia ,glucocorticoids ,steroids ,Clinical sciences ,Medical microbiology - Abstract
BackgroundSevere coccidioidomycosis presenting with respiratory failure is an uncommon manifestation of disease. Current knowledge of this condition is limited to case reports and small case series.MethodsA retrospective multicenter review of patients with coccidioidomycosis-associated acute respiratory distress syndrome (CA-ARDS) was conducted. It assessed clinical and laboratory variables at the time of presentation, reviewed the treatment course, and compared this cohort with a national database of patients with noncoccidioidomycosis ARDS. Survivors and nonsurvivors of coccidioidomycosis were also compared to determine prognostic factors.ResultsIn this study, CA-ARDS (n = 54) was most common in males, those of Hispanic ethnicity, and those with concurrent diabetes mellitus. As compared with the PETAL network database (Prevention and Early Treatment of Acute Lung Injury; n = 1006), patients with coccidioidomycosis were younger, had fewer comorbid conditions, and were less acidemic. The 90-day mortality was 15.4% for patients with coccidioidomycosis, as opposed to 42.6% (P < .0001) for patients with noncoccidioidomycosis ARDS. Patients with coccidioidomycosis who died, as compared with those who survived, were older, had higher APACHE II scores (Acute Physiology and Chronic Health Evaluation), and did not receive corticosteroid therapy.ConclusionsCA-ARDS is an uncommon but morbid manifestation of infection. When compared with a national database, the overall mortality appears favorable vs other causes of ARDS. Patients with CA-ARDS had a low overall mortality but required prolonged antifungal therapy. The utility of corticosteroids in this condition remains unconfirmed.
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- 2024
167. Systemic advantage has a meaningful relationship with grade outcomes in students early STEM courses at six research universities.
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Castle, Sarah, Byrd, W, Koester, Benjamin, Pearson, Meaghan, Bonem, Emily, Caporale, Natalia, Cwik, Sonja, Fiorini, Stefano, Li, Yangqiuting, Mead, Chris, Rypkema, Heather, Sweeder, Ryan, Valdivia Medinaceli, Montserrat, Whitcomb, Kyle, Brownell, Sara, Levesque-Bristol, Chantal, Molinaro, Marco, Singh, Chandralekha, McKay, Timothy, Matz, Rebecca, and Denaro, Kameryn
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Course grades ,Generation status ,Grade anomaly ,Income ,Introductory courses ,Race/ethnicity ,STEM ,Sex ,Systemic advantage index ,Undergraduate - Abstract
BACKGROUND: Large introductory lecture courses are frequently post-secondary students first formal interaction with science, technology, engineering, and mathematics (STEM) disciplines. Grade outcomes in these courses are often disparate across student populations, which, in turn, has implications for student retention. This study positions such disparities as a manifestation of systemic inequities along the dimensions of sex, race/ethnicity, income, and first-generation status and investigates the extent to which they are similar across peer institutions. RESULTS: We examined grade outcomes in a selected set of early STEM courses across six large, public, research-intensive universities in the United States over ten years. In this sample of more than 200,000 STEM course enrollments, we find that course grade benefits increase significantly with the number of systemic advantages students possess at all six institutions. The observed trends in academic outcomes versus advantage are strikingly similar across universities despite the fact that we did not control for differences in grading practices, contexts, and instructor and student populations. The findings are concerning given that these courses are often students first post-secondary STEM experiences. CONCLUSIONS: STEM course grades are typically lower than those in other disciplines; students taking them often pay grade penalties. The systemic advantages some student groups experience are correlated with significant reductions in these grade penalties at all six institutions. The consistency of these findings across institutions and courses supports the claim that inequities in STEM education are a systemic problem, driven by factors that go beyond specific courses or individual institutions. Our work provides a basis for the exploration of contexts where inequities are exacerbated or reduced and can be used to advocate for structural change within STEM education. To cultivate more equitable learning environments, we must reckon with how pervasive structural barriers in STEM courses negatively shape the experiences of marginalized students. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40594-024-00474-7.
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- 2024
168. The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities.
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Pearson, Thomas, Vitalis, Debbie, Pratt, Charlotte, Campo, Rebecca, Armoundas, Antonis, Au, David, Beech, Bettina, Brazhnik, Olga, Chute, Christopher, Davidson, Karina, Diez-Roux, Ana, Fine, Lawrence, Gabriel, Davera, Groenveld, Peter, Hall, Jaclyn, Hamilton, Alison, Hu, Hui, Ji, Heng, Kind, Amy, Kraus, William, Krumholz, Harlan, Mensah, George, Merchant, Raina, Mozaffarian, Dariush, Murray, David, Neumark-Sztainer, Dianne, Goff, David, and Petersen, Maya
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data science ,health equity ,health promotion ,implementation science ,personalized medicine ,precision analytics - Abstract
Precision prevention embraces personalized prevention but includes broader factors such as social determinants of health to improve cardiovascular health. The quality, quantity, precision, and diversity of data relatable to individuals and communities continue to expand. New analytical methods can be applied to these data to create tools to attribute risk, which may allow a better understanding of cardiovascular health disparities. Interventions using these analytic tools should be evaluated to establish feasibility and efficacy for addressing cardiovascular disease disparities in diverse individuals and communities. Training in these approaches is important to create the next generation of scientists and practitioners in precision prevention. This state-of-the-art review is based on a workshop convened to identify current gaps in knowledge and methods used in precision prevention intervention research, discuss opportunities to expand trials of implementation science to close the health equity gaps, and expand the education and training of a diverse precision prevention workforce.
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- 2024
169. Longitudinal analysis of physical function in older adults: The effects of physical inactivity and exercise training.
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Manning, Kenneth, Hall, Katherine, Sloane, Richard, Magistro, Daniele, Rabaglietti, Emanuela, Castle, Steven, Kopp, Teresa, Giffuni, Jamie, Katzel, Leslie, McDonald, Michelle, Miyamoto, Miles, Pearson, Megan, Jennings, Stephen, Bettger, Janet, Morey, Miriam, and Lee, Cathy
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clinical ,cohort ,physical activity ,physical performance ,sedentary ,Humans ,Aged ,Aged ,80 and over ,Sedentary Behavior ,Exercise ,Aging - Abstract
Lack of exercise contributes to systemic inflammation and is a major cause of chronic disease. The long-term impact of initiating and sustaining exercise in late life, as opposed to sustaining a sedentary lifestyle, on whole-body health measures such as physical performance is not well known. This is an exploratory study to compare changes in physical performance among older adults initiating exercise late in life versus inactive older adults. Data from two observational cohorts were included in this analysis, representing two activity groups. The Active group cohort comprises older adults (n = 318; age 72.5 ± 7.2 years) enrolled in a supervised exercise program, Gerofit. The inactive group comprises older adults (n = 146; age 74.5 ± 5.5 years) from the Italian study Act on Ageing (AOA) who self-reported being inactive. Participants in both groups completed physical performance battery at baseline and 1-year including: 6-min walk test, 30-s chair stand, and timed up-and-go. Two-sample t-tests measured differences between Gerofit and AOA at baseline and 1-year across all measures. Significant between-group effects were seen for all performance measures (ps = 0.001). The AOA group declined across all measures from baseline to 1 year (range -18% to -24% change). The Gerofit group experienced significant gains in function for all measures (range +10% to +31% change). Older adults who initiated routine, sustained exercise were protected from age-related declines in physical performance, while those who remained sedentary suffered cumulative deficits across strength, aerobic endurance, and mobility. Interventions to reduce sedentary behaviors and increase physical activity are both important to promote multi-system, whole-body health.
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- 2024
170. Citizen science, accessibility, art & science, critical thinking, policy and engagement: thoughts and lessons learned from the REINFORCE experience
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Angelidakis, Stylianos, Avgitas, Theodore, Chaniotakis, Emmanouil, Casado, Johanna, Coyle, Paschal, de Wasseige, Gwenhaël, Di Renzo, Francesco, Fabian, Claudia Magdalena, Fassouliotis, Dimitrios, Fidecaro, Francesco, Garcia, Beatriz, Hemming, Gary, Kourkoumelis, Christine, Breton, Rémy Le, Marteau, Jacques, Mureddu, Francesco, Napolano, Vincenzo, Osimanti, Francesco, Oukacha, Enzo, Panagopoulou, Maria, Pearson, James, Razzano, Massimiliano, Sotiriou, Sofoklis, Serjeant, Stephen, Spagnuolo, Francesca, Unterfrauner, Elisabeth, and Vourakis, Stylianos
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- 2024
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171. Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s = 13 TeV using leptonic W boson decays
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Hussain, P. S., Jeitler, M., Krammer, N., Li, A., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Janssen, T., Van Laer, T., Van Mechelen, P., Breugelmans, N., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., Heyen, F., Lowette, S., Makarenko, I., Müller, D., Tavernier, S., Tytgat, M., Van Onsem, G. P., Van Putte, S., Vannerom, D., Bilin, B., Clerbaux, B., Das, A. K., De Lentdecker, G., Evard, H., Favart, L., Gianneios, P., Jaramillo, J., Khalilzadeh, A., Khan, F. A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Shahzad, M. A., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Gokbulut, G., Hong, Y., Knolle, J., Lambrecht, L., Marckx, D., Mota Amarilo, K., Samalan, A., Skovpen, K., Van Den Bossche, N., van der Linden, J., Wezenbeek, L., Benecke, A., Bethani, A., Bruno, G., Caputo, C., De Favereau De Jeneret, J., Delaere, C., Donertas, I. S., Giammanco, A., Guzel, A. O., Jain, Sa., Lemaitre, V., Lidrych, J., Mastrapasqua, P., Tran, T. T., Wertz, S., Alves, G. A., Alves Gallo Pereira, M., Coelho, E., Correia Silva, G., Hensel, C., Menezes De Oliveira, T., Mora Herrera, C., Moraes, A., Rebello Teles, P., Soeiro, M., Vilela Pereira, A., Aldá Júnior, W. L., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Gomes De Souza, R., Macedo, M., Martins, J., Mundim, L., Nogima, H., Pinheiro, J. P., Santoro, A., Sznajder, A., Thiel, M., Bernardes, C. A., Calligaris, L., Fernandez Perez Tomei, T. R., Gregores, E. M., Lopes Da Costa, B., Maietto Silverio, I., Mercadante, P. G., Novaes, S. F., Orzari, B., Padula, Sandra S., Aleksandrov, A., Antchev, G., Hadjiiska, R., Iaydjiev, P., Misheva, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Petrov, A., Shumka, E., Keshri, S., Laroze, D., Thakur, S., Cheng, T., Javaid, T., Yuan, L., Hu, Z., Liang, Z., Liu, J., Yi, K., Chen, G. M., Chen, H. S., Chen, M., Iemmi, F., Jiang, C. H., Kapoor, A., Liao, H., Liu, Z.-A., Sharma, R., Song, J. N., Tao, J., Wang, C., Wang, J., Wang, Z., Zhang, H., Zhao, J., Agapitos, A., Ban, Y., Deng, S., Guo, B., Jiang, C., Levin, A., Li, C., Li, Q., Mao, Y., Qian, S., Qian, S. J., Qin, X., Sun, X., Wang, D., Yang, H., Zhang, L., Zhao, Y., Zhou, C., Yang, S., You, Z., Jaffel, K., Lu, N., Bauer, G., Li, B., Zhang, J., Gao, X., Li, Y., Lin, Z., Lu, C., Xiao, M., Avila, C., Barbosa Trujillo, D. A., Cabrera, A., Florez, C., Fraga, J., Reyes Vega, J. A., Ramirez, F., Rendón, C., Rodriguez, M., Ruales Barbosa, A. A., Ruiz Alvarez, J. D., Giljanovic, D., Godinovic, N., Lelas, D., Sculac, A., Kovac, M., Petkovic, A., Sculac, T., Bargassa, P., Brigljevic, V., Chitroda, B. K., Ferencek, D., Jakovcic, K., Mishra, S., Starodumov, A., Susa, T., Attikis, A., Christoforou, K., Hadjiagapiou, A., Leonidou, C., Mousa, J., Nicolaou, C., Paizanos, L., Ptochos, F., Razis, P. A., Rykaczewski, H., Saka, H., Stepennov, A., Finger, M., Finger, Jr., M., Kveton, A., Carrera Jarrin, E., Assran, Y., El-mahdy, B., Elgammal, S., Mahmoud, M. A., Mohammed, Y., Ehataht, K., Kadastik, M., Lange, T., Nandan, S., Nielsen, C., Pata, J., Raidal, M., Tani, L., Veelken, C., Kirschenmann, H., Osterberg, K., Voutilainen, M., Bharthuar, S., Bin Norjoharuddeen, N., Brücken, E., Garcia, F., Inkaew, P., Kallonen, K. T. S., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Martikainen, L., Myllymäki, M., Rantanen, M. m., Siikonen, H., Tuominiemi, J., Luukka, P., Petrow, H., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Gras, P., Hamel de Monchenault, G., Kumar, M., Lohezic, V., Malcles, J., Orlandi, F., Portales, L., Rosowsky, A., Sahin, M. Ö., Savoy-Navarro, A., Simkina, P., Titov, M., Tornago, M., Beaudette, F., Boldrini, G., Busson, P., Cappati, A., Charlot, C., Chiusi, M., Damas, F., Davignon, O., De Wit, A., Ehle, I. T., Fontana Santos Alves, B. A., Ghosh, S., Gilbert, A., Granier de Cassagnac, R., Hakimi, A., Harikrishnan, B., Kalipoliti, L., Liu, G., Nguyen, M., Ochando, C., Salerno, R., Sauvan, J. B., Sirois, Y., Urda Gómez, L., Vernazza, E., Zabi, A., Zghiche, A., Agram, J.-L., Andrea, J., Apparu, D., Bloch, D., Brom, J.-M., Chabert, E. C., Collard, C., Falke, S., Goerlach, U., Haeberle, R., Le Bihan, A.-C., Meena, M., Poncet, O., Saha, G., Sessini, M. A., Van Hove, P., Vaucelle, P., Di Florio, A., Amram, D., Beauceron, S., Blancon, B., Boudoul, G., Chanon, N., Contardo, D., Depasse, P., Dozen, C., El Mamouni, H., Fay, J., Gascon, S., Gouzevitch, M., Greenberg, C., Grenier, G., Ille, B., Jourd‘huy, E., Laktineh, I. B., Lethuillier, M., Mirabito, L., Perries, S., Purohit, A., Vander Donckt, M., Verdier, P., Xiao, J., Bagaturia, I., Lomidze, I., Tsamalaidze, Z., Botta, V., Consuegra Rodríguez, S., Feld, L., Klein, K., Lipinski, M., Meuser, D., Pauls, A., Pérez Adán, D., Röwert, N., Teroerde, M., Diekmann, S., Dodonova, A., Eich, N., Eliseev, D., Engelke, F., Erdmann, J., Erdmann, M., Fackeldey, P., Fischer, B., Hebbeker, T., Hoepfner, K., Ivone, F., Jung, A., Lee, M. y., Mausolf, F., Merschmeyer, M., Meyer, A., Mukherjee, S., Noll, D., Nowotny, F., Pozdnyakov, A., Rath, Y., Redjeb, W., Rehm, F., Reithler, H., Sarkisovi, V., Schmidt, A., Seth, C., Sharma, A., Spah, J. L., Stein, A., Torres Da Silva De Araujo, F., Wiedenbeck, S., Zaleski, S., Dziwok, C., Flügge, G., Kress, T., Nowack, A., Pooth, O., Stahl, A., Ziemons, T., Zotz, A., Aarup Petersen, H., Aldaya Martin, M., Alimena, J., Amoroso, S., An, Y., Bach, J., Baxter, S., Bayatmakou, M., Becerril Gonzalez, H., Behnke, O., Belvedere, A., Blekman, F., Borras, K., Campbell, A., Cardini, A., Cheng, C., Colombina, F., De Silva, M., Eckerlin, G., Eckstein, D., Estevez Banos, L. I., Filatov, O., Gallo, E., Geiser, A., Guglielmi, V., Guthoff, M., Hinzmann, A., Jeppe, L., Kaech, B., Kasemann, M., Kleinwort, C., Kogler, R., Komm, M., Krücker, D., Lange, W., Leyva Pernia, D., Lipka, K., Lohmann, W., Lorkowski, F., Mankel, R., Melzer-Pellmann, I.-A., Mendizabal Morentin, M., Meyer, A. B., Milella, G., Moral Figueroa, K., Mussgiller, A., Nair, L. P., Niedziela, J., Nürnberg, A., Otarid, Y., Park, J., Ranken, E., Raspereza, A., Rastorguev, D., Rübenach, J., Rygaard, L., Saggio, A., Scham, M., Schnake, S., Schütze, P., Schwanenberger, C., Selivanova, D., Sharko, K., Shchedrolosiev, M., Stafford, D., Vazzoler, F., Ventura Barroso, A., Walsh, R., Wang, D., Wang, Q., Wen, Y., Wichmann, K., Wiens, L., Wissing, C., Yang, Y., Zimermmane Castro Santos, A., Albrecht, A., Albrecht, S., Antonello, M., Bein, S., Benato, L., Bollweg, S., Bonanomi, M., Connor, P., El Morabit, K., Fischer, Y., Garutti, E., Grohsjean, A., Haller, J., Jabusch, H. R., Kasieczka, G., Keicher, P., Klanner, R., Korcari, W., Kramer, T., Kuo, C. c., Kutzner, V., Labe, F., Lange, J., Lobanov, A., Matthies, C., Moureaux, L., Mrowietz, M., Nigamova, A., Nissan, Y., Paasch, A., Pena Rodriguez, K. J., Quadfasel, T., Raciti, B., Rieger, M., Savoiu, D., Schindler, J., Schleper, P., Schröder, M., Schwandt, J., Sommerhalder, M., Stadie, H., Steinbrück, G., Tews, A., Wolf, M., Brommer, S., Burkart, M., Butz, E., Chwalek, T., Dierlamm, A., Droll, A., Elicabuk, U., Faltermann, N., Giffels, M., Gottmann, A., Hartmann, F., Hofsaess, R., Horzela, M., Husemann, U., Kieseler, J., Klute, M., Koppenhöfer, R., Lawhorn, J. M., Link, M., Lintuluoto, A., Maier, B., Maier, S., Mitra, S., Mormile, M., Müller, Th., Neukum, M., Oh, M., Pfeffer, E., Presilla, M., Quast, G., Rabbertz, K., Regnery, B., Shadskiy, N., Shvetsov, I., Simonis, H. J., Sowa, L., Stockmeier, L., Tauqeer, K., Toms, M., Trevisani, N., Von Cube, R. F., Wassmer, M., Wieland, S., Wittig, F., Wolf, R., Zuo, X., Anagnostou, G., Daskalakis, G., Kyriakis, A., Papadopoulos, A., Stakia, A., Kontaxakis, P., Melachroinos, G., Painesis, Z., Papavergou, I., Paraskevas, I., Saoulidou, N., Theofilatos, K., Tziaferi, E., Vellidis, K., Zisopoulos, I., Bakas, G., Chatzistavrou, T., Karapostoli, G., Kousouris, K., Papakrivopoulos, I., Siamarkou, E., Tsipolitis, G., Zacharopoulou, A., Adamidis, K., Bestintzanos, I., Evangelou, I., Foudas, C., Kamtsikis, C., Katsoulis, P., Kokkas, P., Kosmoglou Kioseoglou, P. G., Manthos, N., Papadopoulos, I., Strologas, J., Hajdu, C., Horvath, D., Márton, K., Rádl, A. J., Sikler, F., Veszpremi, V., Csanád, M., Farkas, K., Fehérkuti, A., Gadallah, M. M. A., Kadlecsik, Á., Major, P., Pásztor, G., Veres, G. I., Ujvari, B., Zilizi, G., Bencze, G., Czellar, S., Molnar, J., Szillasi, Z., Nemes, F., Novak, T., Bansal, S., Beri, S. B., Bhatnagar, V., Chaudhary, G., Chauhan, S., Dhingra, N., Kaur, A., Kaur, A., Kaur, H., Kaur, M., Kumar, S., Sandeep, K., Sheokand, T., Singh, J. B., Singla, A., Ahmed, A., Bhardwaj, A., Chhetri, A., Choudhary, B. C., Kumar, A., Kumar, A., Naimuddin, M., Ranjan, K., Saini, M. K., Saumya, S., Baradia, S., Barman, S., Bhattacharya, S., Das Gupta, S., Dutta, S., Dutta, S., Sarkar, S., Ameen, M. M., Behera, P. K., Behera, S. C., Chatterjee, S., Dash, G., Jana, P., Kalbhor, P., Kamble, S., Komaragiri, J. R., Kumar, D., Pujahari, P. R., Saha, N. R., Sharma, A., Sikdar, A. K., Singh, R. K., Verma, P., Verma, S., Vijay, A., Dugad, S., Mohanty, G. B., Parida, B., Shelake, M., Suryadevara, P., Bala, A., Banerjee, S., Chatterjee, R. M., Guchait, M., Jain, Sh., Jaiswal, A., Kumar, S., Majumder, G., Mazumdar, K., Parolia, S., Thachayath, A., Bahinipati, S., Kar, C., Maity, D., Mal, P., Mishra, T., Muraleedharan Nair Bindhu, V. K., Naskar, K., Nayak, A., Nayak, S., Pal, K., Sadangi, P., Swain, S. K., Varghese, S., Vats, D., Acharya, S., Alpana, A., Dube, S., Gomber, B., Hazarika, P., Kansal, B., Laha, A., Sahu, B., Sharma, S., Vaish, K. Y., Bakhshiansohi, H., Jafari, A., Zeinali, M., Bashiri, S., Chenarani, S., Etesami, S. M., Hosseini, Y., Khakzad, M., Khazaie, E., Mohammadi Najafabadi, M., Tizchang, S., Felcini, M., Grunewald, M., Abbrescia, M., Colaleo, A., Creanza, D., D’Anzi, B., De Filippis, N., De Palma, M., Elmetenawee, W., Fiore, L., Iaselli, G., Longo, L., Louka, M., Maggi, G., Maggi, M., Margjeka, I., Mastrapasqua, V., My, S., Nuzzo, S., Pellecchia, A., Pompili, A., Pugliese, G., Radogna, R., Ramos, D., Ranieri, A., Silvestris, L., Simone, F. M., Sözbilir, Ü., Stamerra, A., Troiano, D., Venditti, R., Verwilligen, P., Zaza, A., Abbiendi, G., Battilana, C., Bonacorsi, D., Capiluppi, P., Castro, A., Cavallo, F. R., Cuffiani, M., Dallavalle, G. M., Diotalevi, T., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Giommi, L., Grandi, C., Guiducci, L., Lo Meo, S., Lorusso, M., Lunerti, L., Marcellini, S., Masetti, G., Navarria, F. L., Paggi, G., Perrotta, A., Primavera, F., Rossi, A. M., Rossi Tisbeni, S., Rovelli, T., Siroli, G. P., Costa, S., Di Mattia, A., Lapertosa, A., Potenza, R., Tricomi, A., Tuve, C., Assiouras, P., Barbagli, G., Bardelli, G., Camaiani, B., Cassese, A., Ceccarelli, R., Ciulli, V., Civinini, C., D’Alessandro, R., Focardi, E., Kello, T., Latino, G., Lenzi, P., Lizzo, M., Meschini, M., Paoletti, S., Papanastassiou, A., Sguazzoni, G., Viliani, L., Benussi, L., Bianco, S., Meola, S., Piccolo, D., Chatagnon, P., Ferro, F., Robutti, E., Tosi, S., Benaglia, A., Brivio, F., Cetorelli, F., De Guio, F., Dinardo, M. E., Dini, P., Gennai, S., Gerosa, R., Ghezzi, A., Govoni, P., Guzzi, L., Lucchini, M. T., Malberti, M., Malvezzi, S., Massironi, A., Menasce, D., Moroni, L., Paganoni, M., Palluotto, S., Pedrini, D., Perego, A., Pinolini, B. S., Pizzati, G., Ragazzi, S., Tabarelli de Fatis, T., Buontempo, S., Cagnotta, A., Carnevali, F., Cavallo, N., Fabozzi, F., Iorio, A. O. M., Lista, L., Paolucci, P., Rossi, B., Ardino, R., Azzi, P., Bacchetta, N., Bisello, D., Bortignon, P., Bortolato, G., Bragagnolo, A., Bulla, A. C. M., Carlin, R., Checchia, P., Dorigo, T., Gasparini, F., Gasparini, U., Gulmini, M., Lusiani, E., Margoni, M., Migliorini, M., Pazzini, J., Ronchese, P., Rossin, R., Simonetto, F., Tosi, M., Triossi, A., Ventura, S., Zanetti, M., Zotto, P., Zucchetta, A., Zumerle, G., Aimè, C., Braghieri, A., Calzaferri, S., Fiorina, D., Montagna, P., Re, V., Riccardi, C., Salvini, P., Vai, I., Vitulo, P., Ajmal, S., Ascioti, M. E., Bilei, G. M., Carrivale, C., Ciangottini, D., Fanò, L., Magherini, M., Mariani, V., Menichelli, M., Moscatelli, F., Rossi, A., Santocchia, A., Spiga, D., Tedeschi, T., Alexe, C. A., Asenov, P., Azzurri, P., Bagliesi, G., Bhattacharya, R., Bianchini, L., Boccali, T., Bossini, E., Bruschini, D., Castaldi, R., Ciocci, M. A., Cipriani, M., D’Amante, V., Dell’Orso, R., Donato, S., Giassi, A., Ligabue, F., Marini, A. C., Matos Figueiredo, D., Messineo, A., Musich, M., Palla, F., Rizzi, A., Rolandi, G., Roy Chowdhury, S., Sarkar, T., Scribano, A., Spagnolo, P., Tenchini, R., Tonelli, G., Turini, N., Vaselli, F., Venturi, A., Verdini, P. 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R., Karunarathna, N., Lee, L., Nibigira, E., Spanier, S., Aebi, D., Ahmad, M., Akhter, T., Bouhali, O., Eusebi, R., Gilmore, J., Huang, T., Kamon, T., Kim, H., Luo, S., Mueller, R., Overton, D., Rathjens, D., Safonov, A., Akchurin, N., Damgov, J., Gogate, N., Hegde, V., Hussain, A., Kazhykarim, Y., Lamichhane, K., Lee, S. W., Mankel, A., Peltola, T., Volobouev, I., Appelt, E., Chen, Y., Greene, S., Gurrola, A., Johns, W., Kunnawalkam Elayavalli, R., Melo, A., Romeo, F., Sheldon, P., Tuo, S., Velkovska, J., Viinikainen, J., Cardwell, B., Chung, H., Cox, B., Hakala, J., Hirosky, R., Ledovskoy, A., Neu, C., Bhattacharya, S., Karchin, P. E., Aravind, A., Banerjee, S., Black, K., Bose, T., Dasu, S., De Bruyn, I., Everaerts, P., Galloni, C., He, H., Herndon, M., Herve, A., Koraka, C. K., Lanaro, A., Loveless, R., Madhusudanan Sreekala, J., Mallampalli, A., Mohammadi, A., Mondal, S., Parida, G., Pétré, L., Pinna, D., Savin, A., Shang, V., Sharma, V., Smith, W. H., Teague, D., Tsoi, H. 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S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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172. TRP-2 / gp100 DNA vaccine and PD-1 checkpoint blockade combination for the treatment of intracranial tumors
- Author
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Pearson, Joshua R. D., Puig-Saenz, Carles, Thomas, Jubini E., Hardowar, Lydia D., Ahmad, Murrium, Wainwright, Louise C., McVicar, Adam M., Brentville, Victoria A., Tinsley, Chris J., Pockley, A. Graham, Durrant, Lindy G., and McArdle, Stephanie E. B.
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- 2024
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173. Search for new physics in high-mass diphoton events from proton-proton collisions at s = 13 TeV
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Hussain, P. S., Jeitler, M., Krammer, N., Li, A., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Van Laer, T., Van Mechelen, P., Breugelmans, N., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., Heyen, F., Lowette, S., Makarenko, I., Müller, D., Tavernier, S., Tytgat, M., Van Onsem, G. P., Van Putte, S., Vannerom, D., Bilin, B., Clerbaux, B., Das, A. K., De Lentdecker, G., Evard, H., Favart, L., Gianneios, P., Jaramillo, J., Khalilzadeh, A., Khan, F. A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Shahzad, M. A., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Gokbulut, G., Hong, Y., Knolle, J., Lambrecht, L., Marckx, D., Mota Amarilo, K., Samalan, A., Skovpen, K., Van Den Bossche, N., van der Linden, J., Wezenbeek, L., Benecke, A., Bethani, A., Bruno, G., Caputo, C., De Favereau De Jeneret, J., Delaere, C., Donertas, I. S., Giammanco, A., Guzel, A. O., Jain, Sa., Lemaitre, V., Lidrych, J., Mastrapasqua, P., Tran, T. T., Wertz, S., Alves, G. A., Alves Gallo Pereira, M., Coelho, E., Correia Silva, G., Hensel, C., Menezes De Oliveira, T., Moraes, A., Rebello Teles, P., Soeiro, M., Vilela Pereira, A., Aldá Júnior, W. L., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Gomes De Souza, R., Macedo, M., Martins, J., Mora Herrera, C., Mundim, L., Nogima, H., Pinheiro, J. P., Santoro, A., Sznajder, A., Thiel, M., Bernardes, C. A., Calligaris, L., Fernandez Perez Tomei, T. R., Gregores, E. M., Maietto Silverio, I., Mercadante, P. G., Novaes, S. F., Orzari, B., Padula, Sandra S., Aleksandrov, A., Antchev, G., Hadjiiska, R., Iaydjiev, P., Misheva, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Petrov, A., Shumka, E., Keshri, S., Thakur, S., Cheng, T., Javaid, T., Yuan, L., Hu, Z., Liang, Z., Liu, J., Yi, K., Chen, G. M., Chen, H. S., Chen, M., Iemmi, F., Jiang, C. H., Kapoor, A., Liao, H., Liu, Z.-A., Sharma, R., Song, J. N., Tao, J., Wang, C., Wang, J., Wang, Z., Zhang, H., Zhao, J., Agapitos, A., Ban, Y., Deng, S., Guo, B., Jiang, C., Levin, A., Li, C., Li, Q., Mao, Y., Qian, S., Qian, S. J., Qin, X., Sun, X., Wang, D., Yang, H., Zhang, L., Zhao, Y., Zhou, C., Yang, S., You, Z., Jaffel, K., Lu, N., Bauer, G., Li, B., Zhang, J., Gao, X., Lin, Z., Lu, C., Xiao, M., Avila, C., Barbosa Trujillo, D. A., Cabrera, A., Florez, C., Fraga, J., Reyes Vega, J. 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M., Kapsiak, C., Krohn, M., Mahon, D., Mans, J., Marzocchi, B., Revering, M., Rusack, R., Saradhy, R., Strobbe, N., Bloom, K., Claes, D. R., Haza, G., Hossain, J., Joo, C., Kravchenko, I., Siado, J. E., Tabb, W., Vagnerini, A., Wightman, A., Yan, F., Yu, D., Bandyopadhyay, H., Hay, L., Hsia, H. w., Iashvili, I., Kalogeropoulos, A., Kharchilava, A., Morris, M., Nguyen, D., Rappoccio, S., Rejeb Sfar, H., Williams, A., Young, P., Alverson, G., Barberis, E., Bonilla, J., Dervan, J., Haddad, Y., Han, Y., Krishna, A., Li, J., Lu, M., Madigan, G., Mccarthy, R., Morse, D. M., Nguyen, V., Orimoto, T., Parker, A., Skinnari, L., Wood, D., Bueghly, J., Dittmer, S., Hahn, K. A., Liu, Y., Miao, Y., Monk, D. G., Schmitt, M. H., Taliercio, A., Velasco, M., Agarwal, G., Band, R., Bucci, R., Castells, S., Das, A., Goldouzian, R., Hildreth, M., Ho, K. W., Hurtado Anampa, K., Ivanov, T., Jessop, C., Lannon, K., Lawrence, J., Loukas, N., Lutton, L., Mariano, J., Marinelli, N., Mcalister, I., McCauley, T., Mcgrady, C., Moore, C., Musienko, Y., Nelson, H., Osherson, M., Piccinelli, A., Ruchti, R., Townsend, A., Wan, Y., Wayne, M., Yockey, H., Zarucki, M., Zygala, L., Basnet, A., Bylsma, B., Carrigan, M., Durkin, L. S., Hill, C., Joyce, M., Nunez Ornelas, M., Wei, K., Winer, B. L., Yates, B. R., Bouchamaoui, H., Das, P., Dezoort, G., Elmer, P., Frankenthal, A., Greenberg, B., Haubrich, N., Kennedy, K., Kopp, G., Kwan, S., Lange, D., Loeliger, A., Marlow, D., Ojalvo, I., Olsen, J., Shevelev, A., Stickland, D., Tully, C., Malik, S., Bakshi, A. S., Chandra, S., Chawla, R., Gu, A., Gutay, L., Jones, M., Jung, A. W., Koshy, A. M., Liu, M., Negro, G., Neumeister, N., Paspalaki, G., Piperov, S., Scheurer, V., Schulte, J. F., Stojanovic, M., Thieman, J., Virdi, A. K., Wang, F., Xie, W., Dolen, J., Parashar, N., Pathak, A., Acosta, D., Carnahan, T., Ecklund, K. M., Fernández Manteca, P. J., Freed, S., Gardner, P., Geurts, F. J. M., Li, W., Lin, J., Miguel Colin, O., Padley, B. P., Redjimi, R., Rotter, J., Yigitbasi, E., Zhang, Y., Bodek, A., de Barbaro, P., Demina, R., Dulemba, J. L., Garcia-Bellido, A., Hindrichs, O., Khukhunaishvili, A., Parmar, N., Parygin, P., Popova, E., Taus, R., Chiarito, B., Chou, J. P., Clark, S. V., Gadkari, D., Gershtein, Y., Halkiadakis, E., Heindl, M., Houghton, C., Jaroslawski, D., Konstantinou, S., Laflotte, I., Lath, A., Montalvo, R., Nash, K., Reichert, J., Routray, H., Saha, P., Salur, S., Schnetzer, S., Somalwar, S., Stone, R., Thayil, S. A., Thomas, S., Vora, J., Wang, H., Ally, D., Delannoy, A. G., Fiorendi, S., Higginbotham, S., Holmes, T., Kanuganti, A. R., Karunarathna, N., Lee, L., Nibigira, E., Spanier, S., Aebi, D., Ahmad, M., Akhter, T., Bouhali, O., Eusebi, R., Gilmore, J., Huang, T., Kamon, T., Kim, H., Luo, S., Mueller, R., Overton, D., Rathjens, D., Safonov, A., Akchurin, N., Damgov, J., Gogate, N., Hegde, V., Hussain, A., Kazhykarim, Y., Lamichhane, K., Lee, S. W., Mankel, A., Peltola, T., Volobouev, I., Appelt, E., Chen, Y., Greene, S., Gurrola, A., Johns, W., Kunnawalkam Elayavalli, R., Melo, A., Romeo, F., Sheldon, P., Tuo, S., Velkovska, J., Viinikainen, J., Cardwell, B., Cox, B., Hakala, J., Hirosky, R., Ledovskoy, A., Neu, C., Bhattacharya, S., Karchin, P. E., Aravind, A., Banerjee, S., Black, K., Bose, T., Dasu, S., De Bruyn, I., Everaerts, P., Galloni, C., He, H., Herndon, M., Herve, A., Koraka, C. K., Lanaro, A., Loveless, R., Madhusudanan Sreekala, J., Mallampalli, A., Mohammadi, A., Mondal, S., Parida, G., Pétré, L., Pinna, D., Savin, A., Shang, V., Sharma, V., Smith, W. H., Teague, D., Tsoi, H. F., Vetens, W., Warden, A., Afanasiev, S., Alexakhin, V., Andreev, V., Andreev, Yu., Aushev, T., Azarkin, M., Babaev, A., Blinov, V., Boos, E., Borshch, V., Budkouski, D., Bunichev, V., Chekhovsky, V., Chistov, R., Danilov, M., Dermenev, A., Dimova, T., Druzhkin, D., Dubinin, M., Dudko, L., Ershov, A., Gavrilov, G., Gavrilov, V., Gninenko, S., Golovtcov, V., Golubev, N., Golutvin, I., Gorbunov, I., Gribushin, A., Ivanov, Y., Kachanov, V., Karjavine, V., Karneyeu, A., Kim, V., Kirakosyan, M., Kirpichnikov, D., Kirsanov, M., Klyukhin, V., Kodolova, O., Konstantinov, D., Korenkov, V., Kozyrev, A., Krasnikov, N., Lanev, A., Levchenko, P., Lychkovskaya, N., Makarenko, V., Malakhov, A., Matveev, V., Murzin, V., Nikitenko, A., Obraztsov, S., Oreshkin, V., Palichik, V., Perelygin, V., Perfilov, M., Polikarpov, S., Popov, V., Radchenko, O., Savina, M., Savrin, V., Shalaev, V., Shmatov, S., Shulha, S., Skovpen, Y., Slabospitskii, S., Smirnov, V., Sosnov, D., Sulimov, V., Terkulov, A., Teryaev, O., Tlisova, I., Toropin, A., Uvarov, L., Uzunian, A., Vorobyev, A., Vorotnikov, G., Voytishin, N., Yuldashev, B. S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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174. Blue rings in Bristlecone pine as a high resolution indicator of past cooling events
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Siekacz, Liliana, Pearson, Charlotte, Salzer, Matthew, Soja-Kukieła, Natalia, and Koprowski, Marcin
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- 2024
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175. 1 Ni de Aquí, Ni de Allá: Reflections on Trying to Fit into a Box
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Rodríguez-Arroyo, Sandra, primary, Walls, Laura C., additional, and Pearson, Ferial, additional
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- 2024
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176. 16 Periodical Publishing and the Independent Press: Nancy Chambers, Thimble Press and Signal: Approaches to Children’s Books
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Pearson, Lucy, primary and Bird, Hazel Sheeky, additional
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- 2024
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177. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.
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Wong, Samantha, Lebois, Lauren, Ely, Timothy, van Rooij, Sanne, Bruce, Steven, Murty, Vishnu, Jovanovic, Tanja, House, Stacey, Beaudoin, Francesca, An, Xinming, Zeng, Donglin, Neylan, Thomas, Clifford, Gari, Linnstaedt, Sarah, Germine, Laura, Bollen, Kenneth, Rauch, Scott, Haran, John, Storrow, Alan, Lewandowski, Christopher, Musey, Paul, Hendry, Phyllis, Sheikh, Sophia, Jones, Christopher, Punches, Brittany, Kurz, Michael, Swor, Robert, Hudak, Lauren, Pascual, Jose, Seamon, Mark, Pearson, Claire, Peak, David, Merchant, Roland, Domeier, Robert, Rathlev, Niels, ONeil, Brian, Sergot, Paulina, Sanchez, Leon, Miller, Mark, Pietrzak, Robert, Joormann, Jutta, Barch, Deanna, Pizzagalli, Diego, Harte, Steven, Elliott, James, Kessler, Ronald, Koenen, Karestan, McLean, Samuel, Ressler, Kerry, Stevens, Jennifer, and Harnett, Nathaniel
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Humans ,Stress Disorders ,Post-Traumatic ,Male ,Female ,Adult ,Diffusion Tensor Imaging ,White Matter ,Internal Capsule ,Child Abuse ,Adult Survivors of Child Abuse ,Middle Aged ,Anisotropy ,Brain ,Depression ,Anxiety ,Self Report ,Young Adult - Abstract
Childhood trauma is a known risk factor for trauma and stress-related disorders in adulthood. However, limited research has investigated the impact of childhood trauma on brain structure linked to later posttraumatic dysfunction. We investigated the effect of childhood trauma on white matter microstructure after recent trauma and its relationship with future posttraumatic dysfunction among trauma-exposed adult participants (n = 202) recruited from emergency departments as part of the AURORA Study. Participants completed self-report scales assessing prior childhood maltreatment within 2-weeks in addition to assessments of PTSD, depression, anxiety, and dissociation symptoms within 6-months of their traumatic event. Fractional anisotropy (FA) obtained from diffusion tensor imaging (DTI) collected at 2-weeks and 6-months was used to index white matter microstructure. Childhood maltreatment load predicted 6-month PTSD symptoms (b = 1.75, SE = 0.78, 95% CI = [0.20, 3.29]) and inversely varied with FA in the bilateral internal capsule (IC) at 2-weeks (p = 0.0294, FDR corrected) and 6-months (p = 0.0238, FDR corrected). We observed a significant indirect effect of childhood maltreatment load on 6-month PTSD symptoms through 2-week IC microstructure (b = 0.37, Boot SE = 0.18, 95% CI = [0.05, 0.76]) that fully mediated the effect of childhood maltreatment load on PCL-5 scores (b = 1.37, SE = 0.79, 95% CI = [-0.18, 2.93]). IC microstructure did not mediate relationships between childhood maltreatment and depressive, anxiety, or dissociative symptomatology. Our findings suggest a unique role for IC microstructure as a stable neural pathway between childhood trauma and future PTSD symptoms following recent trauma. Notably, our work did not support roles of white matter tracts previously found to vary with PTSD symptoms and childhood trauma exposure, including the cingulum bundle, uncinate fasciculus, and corpus callosum. Given the IC contains sensory fibers linked to perception and motor control, childhood maltreatment might impact the neural circuits that relay and process threat-related inputs and responses to trauma.
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- 2023
178. A multifunctional Wnt regulator underlies the evolution of rodent stripe patterns
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Johnson, Matthew R, Li, Sha, Guerrero-Juarez, Christian F, Miller, Pearson, Brack, Benjamin J, Mereby, Sarah A, Moreno, Jorge A, Feigin, Charles Y, Gaska, Jenna, Rivera-Perez, Jaime A, Nie, Qing, Ploss, Alexander, Shvartsman, Stanislav Y, and Mallarino, Ricardo
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Biochemistry and Cell Biology ,Biological Sciences ,Genetics ,1.1 Normal biological development and functioning ,Mice ,Animals ,Rodentia ,Reproducibility of Results ,Pigmentation ,Ecology ,Evolutionary biology ,Environmental management - Abstract
Animal pigment patterns are excellent models to elucidate mechanisms of biological organization. Although theoretical simulations, such as Turing reaction-diffusion systems, recapitulate many animal patterns, they are insufficient to account for those showing a high degree of spatial organization and reproducibility. Here, we study the coat of the African striped mouse (Rhabdomys pumilio) to uncover how periodic stripes form. Combining transcriptomics, mathematical modelling and mouse transgenics, we show that the Wnt modulator Sfrp2 regulates the distribution of hair follicles and establishes an embryonic prepattern that foreshadows pigment stripes. Moreover, by developing in vivo gene editing in striped mice, we find that Sfrp2 knockout is sufficient to alter the stripe pattern. Strikingly, mutants exhibited changes in pigmentation, revealing that Sfrp2 also regulates hair colour. Lastly, through evolutionary analyses, we find that striped mice have evolved lineage-specific changes in regulatory elements surrounding Sfrp2, many of which may be implicated in modulating the expression of this gene. Altogether, our results show that a single factor controls coat pattern formation by acting both as an orienting signalling mechanism and a modulator of pigmentation. More broadly, our work provides insights into how spatial patterns are established in developing embryos and the mechanisms by which phenotypic novelty originates.
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- 2023
179. Large-area photon calorimeter with Ir-Pt bilayer transition-edge sensor for the CUPID experiment
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Singh, V, Beretta, M, Hansen, EV, Vetter, KJ, Benato, G, Marini, L, Capelli, C, Fujikawa, BK, Schmidt, B, Chang, CL, Kolomensky, Yu G, Welliver, B, Kwok, WK, Pearson, J, Welp, U, Lisovenko, M, Wang, G, Yefremenko, V, Zhang, J, and Novosad, V
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Physical Sciences ,Engineering ,Physical sciences - Abstract
CUPID is a next-generation neutrinoless double-β decay experiment that will require cryogenic light detectors to improve background suppression, via the simultaneous readout of heat and light channels from its scintillating crystals. In this work, we showcase light detectors based on an alternative Ir-Pt bilayer transition-edge sensor. We have performed a systematic study to improve the thermal coupling between the photon absorber and the sensor, and thereby its responsivity. Our first devices meet CUPID's baseline noise requirement of
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- 2023
180. Effects of a clinic-based reproductive empowerment intervention on proximal outcomes of contraceptive use, self-efficacy, attitudes, and awareness and use of survivor services: a cluster-controlled trial in Nairobi, Kenya.
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Uysal, Jasmine, Boyce, Sabrina, Undie, Chi-Chi, Liambila, Wilson, Wendoh, Seri, Pearson, Erin, Johns, Nicole, and Silverman, Jay
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contraceptives ,family planning ,intervention ,intimate partner violence ,reproductive coercion ,Female ,Humans ,Contraceptive Agents ,Kenya ,Self Efficacy ,Family Planning Services ,Attitude - Abstract
This study was undertaken to evaluate the effect of a reproductive empowerment contraceptive counselling intervention (ARCHES) adapted to private clinics in Nairobi, Kenya on proximal outcomes of contraceptive use and covert use, self-efficacy, awareness and use of intimate partner violence (IPV) survivor services, and attitudes justifying reproductive coercion (RC) and IPV. We conducted a cluster-controlled trial among female family planning patients (N = 659) in six private clinics non-randomly assigned to ARCHES or control in and around Nairobi, Kenya. Patients completed interviews immediately before (baseline) and after (exit) treatment and at three- and six-month follow-up. We use inverse probability by treatment weighting (IPTW) applied to difference-in-differences marginal structural models to estimate the treatment effect using a modified intent-to-treat approach. After IPTW, women receiving ARCHES contraceptive counselling, relative to controls, were more likely to receive a contraceptive method at exit (86% vs. 75%, p
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- 2023
181. Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.
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Zeamer, Abigail, Salive, Marie-Claire, An, Xinming, Beaudoin, Francesca, House, Stacey, Stevens, Jennifer, Zeng, Donglin, Neylan, Thomas, Clifford, Gari, Linnstaedt, Sarah, Rauch, Scott, Storrow, Alan, Lewandowski, Christopher, Musey, Paul, Hendry, Phyllis, Sheikh, Sophia, Jones, Christopher, Punches, Brittany, Swor, Robert, Hudak, Lauren, Pascual, Jose, Seamon, Mark, Harris, Erica, Pearson, Claire, Peak, David, Merchant, Roland, Domeier, Robert, Rathlev, Niels, ONeil, Brian, Sergot, Paulina, Sanchez, Leon, Bruce, Steven, Kessler, Ronald, Koenen, Karestan, McLean, Samuel, Bucci, Vanni, and Haran, John
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Adult ,Humans ,Microbiota ,Stress Disorders ,Post-Traumatic ,Gastrointestinal Microbiome ,Feces ,Biological Availability - Abstract
Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue to understanding mechanisms as well as possibilities for intervention. Microbiome composition after trauma exposure has been poorly examined regarding neuropsychiatric outcomes. We aimed to determine whether the gut microbiomes of trauma-exposed emergency department patients who develop APNS have dysfunctional gut microbiome profiles and discover potential associated mechanisms. We performed metagenomic analysis on stool samples (n = 51) from a subset of adults enrolled in the Advancing Understanding of RecOvery afteR traumA (AURORA) study. Two-, eight- and twelve-week post-trauma outcomes for post-traumatic stress disorder (PTSD) (PTSD checklist for DSM-5), normalized depression scores (PROMIS Depression Short Form 8b) and somatic symptom counts were collected. Generalized linear models were created for each outcome using microbial abundances and relevant demographics. Mixed-effect random forest machine learning models were used to identify associations between APNS outcomes and microbial features and encoded metabolic pathways from stool metagenomics. Microbial species, including Flavonifractor plautii, Ruminococcus gnavus and, Bifidobacterium species, which are prevalent commensal gut microbes, were found to be important in predicting worse APNS outcomes from microbial abundance data. Notably, through APNS outcome modeling using microbial metabolic pathways, worse APNS outcomes were highly predicted by decreased L-arginine related pathway genes and increased citrulline and ornithine pathways. Common commensal microbial species are enriched in individuals who develop APNS. More notably, we identified a biological mechanism through which the gut microbiome reduces global arginine bioavailability, a metabolic change that has also been demonstrated in the plasma of patients with PTSD.
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- 2023
182. The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries
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Kimberly C. Doell, Boryana Todorova, Madalina Vlasceanu, Joseph B. Bak Coleman, Ekaterina Pronizius, Philipp Schumann, Flavio Azevedo, Yash Patel, Michael M. Berkebile-Wineberg, Cameron Brick, Florian Lange, Samantha J. Grayson, Yifei Pei, Alek Chakroff, Karlijn L. van den Broek, Claus Lamm, Denisa Vlasceanu, Sara M. Constantino, Steve Rathje, Danielle Goldwert, Ke Fang, Salvatore Maria Aglioti, Mark Alfano, Andy J. Alvarado-Yepez, Angélica Andersen, Frederik Anseel, Matthew A. J. Apps, Chillar Asadli, Fonda Jane Awuor, Piero Basaglia, Jocelyn J. Bélanger, Sebastian Berger, Paul Bertin, Michał Białek, Olga Bialobrzeska, Michelle Blaya-Burgo, Daniëlle N. M. Bleize, Simen Bø, Lea Boecker, Paulo S. Boggio, Sylvie Borau, Björn Bos, Ayoub Bouguettaya, Markus Brauer, Tymofii Brik, Roman Briker, Tobias Brosch, Ondrej Buchel, Daniel Buonauro, Radhika Butalia, Héctor Carvacho, Sarah A. E. Chamberlain, Hang-Yee Chan, Dawn Chow, Dongil Chung, Luca Cian, Noa Cohen-Eick, Luis Sebastian Contreras-Huerta, Davide Contu, Vladimir Cristea, Jo Cutler, Silvana D’Ottone, Jonas De keersmaecker, Sarah Delcourt, Sylvain Delouvée, Kathi Diel, Benjamin D. Douglas, Moritz A. Drupp, Shreya Dubey, Jānis Ekmanis, Christian T. Elbaek, Mahmoud Elsherif, Iris M. Engelhard, Yannik A. Escher, Tom W. Etienne, Laura Farage, Ana Rita Farias, Stefan Feuerriegel, Andrej Findor, Lucia Freira, Malte Friese, Neil Philip Gains, Albina Gallyamova, Sandra J. Geiger, Oliver Genschow, Biljana Gjoneska, Theofilos Gkinopoulos, Beth Goldberg, Amit Goldenberg, Sarah Gradidge, Simone Grassini, Kurt Gray, Sonja Grelle, Siobhán M. Griffin, Lusine Grigoryan, Ani Grigoryan, Dmitry Grigoryev, June Gruber, Johnrev Guilaran, Britt Hadar, Ulf J. J. Hahnel, Eran Halperin, Annelie J. Harvey, Christian A. P. Haugestad, Aleksandra M. Herman, Hal E. Hershfield, Toshiyuki Himichi, Donald W. Hine, Wilhelm Hofmann, Lauren Howe, Enma T. Huaman-Chulluncuy, Guanxiong Huang, Tatsunori Ishii, Ayahito Ito, Fanli Jia, John T. Jost, Veljko Jovanović, Dominika Jurgiel, Ondřej Kácha, Reeta Kankaanpää, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, Keren Kaplan Mintz, Ilker Kaya, Ozgur Kaya, Narine Khachatryan, Anna Klas, Colin Klein, Christian A. Klöckner, Lina Koppel, Alexandra I. Kosachenko, Emily J. Kothe, Ruth Krebs, Amy R. Krosch, Andre P. M. Krouwel, Yara Kyrychenko, Maria Lagomarsino, Julia Lee Cunningham, Jeffrey Lees, Tak Yan Leung, Neil Levy, Patricia L. Lockwood, Chiara Longoni, Alberto López Ortega, David D. Loschelder, Jackson G. Lu, Yu Luo, Joseph Luomba, Annika E. Lutz, Johann M. Majer, Ezra Markowitz, Abigail A. Marsh, Karen Louise Mascarenhas, Bwambale Mbilingi, Winfred Mbungu, Cillian McHugh, Marijn H. C. Meijers, Hugo Mercier, Fenant Laurent Mhagama, Katerina Michalaki, Nace Mikus, Sarah G. Milliron, Panagiotis Mitkidis, Fredy S. Monge-Rodríguez, Youri L. Mora, Michael J. Morais, David Moreau, Kosuke Motoki, Manuel Moyano, Mathilde Mus, Joaquin Navajas, Tam Luong Nguyen, Dung Minh Nguyen, Trieu Nguyen, Laura Niemi, Sari R. R. Nijssen, Gustav Nilsonne, Jonas P. Nitschke, Laila Nockur, Ritah Okura, Sezin Öner, Asil Ali Özdoğru, Helena Palumbo, Costas Panagopoulos, Maria Serena Panasiti, Philip Pärnamets, Mariola Paruzel-Czachura, Yuri G. Pavlov, César Payán-Gómez, Adam R. Pearson, Leonor Pereira da Costa, Hannes M. Petrowsky, Stefan Pfattheicher, Nhat Tan Pham, Vladimir Ponizovskiy, Clara Pretus, Gabriel G. Rêgo, Ritsaart Reimann, Shawn A. Rhoads, Julian Riano-Moreno, Isabell Richter, Jan Philipp Röer, Jahred Rosa-Sullivan, Robert M. Ross, Anandita Sabherwal, Toshiki Saito, Oriane Sarrasin, Nicolas Say, Katharina Schmid, Michael T. Schmitt, Philipp Schoenegger, Christin Scholz, Mariah G. Schug, Stefan Schulreich, Ganga Shreedhar, Eric Shuman, Smadar Sivan, Hallgeir Sjåstad, Meikel Soliman, Katia Soud, Tobia Spampatti, Gregg Sparkman, Ognen Spasovski, Samantha K. Stanley, Jessica A. Stern, Noel Strahm, Yasushi Suko, Sunhae Sul, Stylianos Syropoulos, Neil C. Taylor, Elisa Tedaldi, Gustav Tinghög, Luu Duc Toan Huynh, Giovanni Antonio Travaglino, Manos Tsakiris, İlayda Tüter, Michael Tyrala, Özden Melis Uluğ, Arkadiusz Urbanek, Danila Valko, Sander van der Linden, Kevin van Schie, Aart van Stekelenburg, Edmunds Vanags, Daniel Västfjäll, Stepan Vesely, Jáchym Vintr, Marek Vranka, Patrick Otuo Wanguche, Robb Willer, Adrian Dominik Wojcik, Rachel Xu, Anjali Yadav, Magdalena Zawisza, Xian Zhao, Jiaying Zhao, Dawid Żuk, and Jay J. Van Bavel
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Science - Abstract
Abstract Climate change is currently one of humanity’s greatest threats. To help scholars understand the psychology of climate change, we conducted an online quasi-experimental survey on 59,508 participants from 63 countries (collected between July 2022 and July 2023). In a between-subjects design, we tested 11 interventions designed to promote climate change mitigation across four outcomes: climate change belief, support for climate policies, willingness to share information on social media, and performance on an effortful pro-environmental behavioural task. Participants also reported their demographic information (e.g., age, gender) and several other independent variables (e.g., political orientation, perceptions about the scientific consensus). In the no-intervention control group, we also measured important additional variables, such as environmentalist identity and trust in climate science. We report the collaboration procedure, study design, raw and cleaned data, all survey materials, relevant analysis scripts, and data visualisations. This dataset can be used to further the understanding of psychological, demographic, and national-level factors related to individual-level climate action and how these differ across countries.
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- 2024
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183. The independent and combined effects of aerobic exercise intensity and dose differentially increase post‐exercise cerebral shear stress and blood flow
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M. Erin Moir, Adam T. Corkery, Kathleen B. Miller, Andrew G. Pearson, Nicole A. Loggie, Avery A. Apfelbeck, Anna J. Howery, and Jill N. Barnes
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aerobic exercise ,blood flow ,internal carotid artery ,shear stress ,Physiology ,QP1-981 - Abstract
Abstract This research examined the impact of aerobic exercise intensity and dose on acute post‐exercise cerebral shear stress and blood flow. Fourteen young adults (27 ± 5 years of age, eight females) completed a maximal oxygen uptake (V̇O2max) treadmill test followed by three randomized study visits: treadmill exercise at 30% of V̇O2max for 30 min, 70% of V̇O2max for 30 min and 70% of V̇O2max for a duration that resulted in caloric expenditure equal to that in the 30% V̇O2max visit (EqEE). A venous blood draw and internal carotid artery (ICA) ultrasound were collected before and immediately following exercise. ICA diameter and blood velocity were determined using automated edge detection software, and blood flow was calculated. Using measures of blood viscosity, shear stress was calculated. Aerobic exercise increased ICA shear stress (time: P = 0.005, condition: P = 0.012) and the increase was greater following exercise at 70% V̇O2max (∆4.1 ± 3.5 dyn/cm2) compared with 30% V̇O2max (∆1.1 ± 1.9 dyn/cm2; P = 0.041). ICA blood flow remained elevated following exercise (time: P = 0.002, condition: P = 0.010) with greater increases after 70% V̇O2max (Δ268 ± 150 mL/min) compared with 30% V̇O2max (∆125 ± 149 mL/min; P = 0.041) or 70% V̇O2max EqEE (∆127 ± 177 mL/min; P = 0.004). Therefore, aerobic exercise resulted in both intensity‐ and dose‐dependent effects on acute post‐exercise ICA blood flow whereby vigorous intensity exercise provoked a larger increase in ICA blood flow compared to light intensity exercise when performed at a higher dose.
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- 2024
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184. Recurrent encephalitis and stroke following cessation of acyclovir prophylaxis in a patient with neonatal herpes simplex virus with RNF213 mutation
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Rutu M. Dave, Janetta Arellano, Charles Grose, and Rachel Pearson
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anti‐NMDAR encephalitis ,HSV‐1 ,RNF213 ,Neurology. Diseases of the nervous system ,RC346-429 ,Pediatrics ,RJ1-570 - Abstract
Abstract Objective Herpes simplex virus (HSV) encephalitis can be associated with many secondary neurological complications, but having multiple episodes of recurrent neurological complications is rare in an individual. Understanding the course of each complication can reduce time to diagnosis and adequate treatment. Additionally, we postulate the role of RNF213 mutation in HSV susceptibility. Methods We describe a unique presentation of HSV‐1 encephalitis in an infant with a pathogenic RNF213 mutation who went on to develop multiple rare neurological complications over the course of her illness. Results Our patient was first diagnosed with neonatal HSV‐1 encephalitis at age 2 weeks. She had recurrence of HSV encephalitis (HSE) with associated vasculopathy that led to right middle cerebral artery and posterior cerebral artery infarctions at 13 months, and then later developed post‐HSE anti‐N‐methyl‐ d‐aspartate receptor encephalitis. All of this occurred concomitant with RNF213 mutation. Interpretation This patient demonstrates that, though rare, multiple neurological complications can occur in a single person, thus highlighting the importance of close surveillance of patients with a history of neonatal HSE and pursuing a broad differential in patients with subtle or recurrent symptoms. Furthermore, we propose a potential role of RNF213 mutation in the pathogenesis of our patient's multiple medical conditions.
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- 2024
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185. 'Luck of the draw really': a qualitative exploration of Australian trainee doctors’ experiences of mandatory research
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Caitlin Brandenburg, Joanne Hilder, Christy Noble, Rhea Liang, Kirsty Forrest, Hitesh Joshi, Gerben Keijzers, Sharon Mickan, David Pearson, Ian A. Scott, Emma Veysey, and Paulina Stehlik
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Medical training ,Trainee ,Research requirements ,Scholarly activity ,Education ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Many medical trainees, prior to achieving specialist status, are required to complete a mandatory research project, the usefulness of which has been debated. The aim of this study was to gain an in-depth understanding of trainees’ experiences and satisfaction of conducting such research projects in Australia. Methods A qualitative descriptive approach was used. Semi-structured interviews with trainees were undertaken between May 2021 and June 2022. Australian medical trainees who had completed a research project as part of specialty training within the past five years were invited to participate. The purposive sample was drawn from participants in a survey on the same topic who had indicated interest in participating in an interview. Interviews explored trainees’ overall experience of and satisfaction with conducting research projects, as well as their perceptions of research training, support, barriers, enablers, and perceived benefits. Interviews were transcribed verbatim and thematically analysed. Results Sixteen medical doctors from seven medical colleges were interviewed. Trainee experience and satisfaction was highly variable between participants and was shaped by four factors: 1) trainees entered their specialty training with their own perspectives on the value and purpose of the research project, informed by their previous experiences with research and perceived importance of research in their planned career path; 2) in conducting the project, enablers including protected time, supervisor support and institutional structures, were vital to shaping their experience; 3) trainees’ access to these enablers was variable, mediated by a combination of luck, and the trainees’ own drive and research skill; and 4) project outcomes, in terms of research merit, learning, career benefits and impacts on patient care. Conclusions Trainee experiences of doing research were mixed, with positive experiences often attributed to chance rather than an intentionally structured learning experience. We believe alternatives to mandatory trainee research projects must be explored, including recognising other forms of research learning activities, and directing scarce resources to supporting the few trainees who plan to pursue clinician researcher careers.
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- 2024
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186. Building a Portuguese coalition for biodiversity genomics
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João P. Marques, Paulo C. Alves, Isabel R. Amorim, Ricardo J. Lopes, Monica Moura, Eugene Myers, Manuela Sim-sim, Carla Sousa-Santos, M. Judite Alves, Paulo A. V. Borges, Thomas Brown, Miguel Carneiro, Carlos Carrapato, Luís M. P. Ceríaco, Claúdio Ciofi, Luís P. da Silva, Genevieve Diedericks, Maria Angela Diroma, Liliana Farelo, Giulio Formenti, Fátima Gil, Miguel Grilo, Alessio Iannucci, Henrique G. Leitão, Cristina Máguas, Ann M. Mc Cartney, Sofia L. Mendes, João M. Moreno, Marco Morselli, Alice Mouton, Chiara Natali, Fernando Pereira, Rúben M. C. Rego, Roberto Resendes, Guilherme Roxo, Hannes Svardal, Helena Trindade, Sara Vicente, Sylke Winkler, Marcela Alvarenga, Andreia J. Amaral, Agostinho Antunes, Paula F. Campos, Adelino V. M. Canário, Rita Castilho, L. Filipe C. Castro, Angelica Crottini, Mónica V. Cunha, Gonçalo Espregueira Themudo, Pedro J. Esteves, Rui Faria, Carlos Rodríguez Fernandes, Jean-Baptiste Ledoux, Bruno Louro, Sara Magalhaes, Octávio S. Paulo, Gareth Pearson, João Pimenta, Francisco Pina-Martins, Teresa L. Santos, Ester Serrão, José Melo-Ferreira, and Vítor C. Sousa
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General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes, overexploitation, or pathogen (re)emergence. The inventory, characterisation, and study of biodiversity at inter- and intra-specific levels using genomics is crucial to promote its preservation and recovery by informing biodiversity conservation policies, management measures, and research. The participation of researchers from Portuguese institutions in the European Reference Genome Atlas (ERGA) initiative and its pilot effort to generate reference genomes for European biodiversity has reinforced the establishment of Biogenome Portugal. This nascent institutional network will connect the national community of researchers in genomics. Here, we describe the Portuguese contribution to ERGA’s pilot effort, which will generate high-quality reference genomes of six species from Portugal that are endemic, iconic, and/or endangered and include plants, insects, and vertebrates (fish, birds, and mammals) from mainland Portugal or the Azores islands. In addition, we outline the objectives of Biogenome Portugal, which aims to (i) promote scientific collaboration, (ii) contribute to advanced training, (iii) stimulate the participation of institutions and researchers based in Portugal in international biodiversity genomics initiatives, and (iv) contribute to the transfer of knowledge to stakeholders and engaging the public to preserve biodiversity. This initiative will strengthen biodiversity genomics research in Portugal and fuel the genomic inventory of Portuguese eukaryotic species. Such efforts will be critical to the conservation of the country’s rich biodiversity and will contribute to ERGA’s goal of generating reference genomes for European species.
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- 2024
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187. Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV using leptonic W boson decays
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, B. Lopes Da Costa, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, D. Laroze, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Y. Li, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Carrera Jarrin, Y. Assran, B. El-mahdy, S. Elgammal, M. A. Mahmoud, Y. Mohammed, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, N. Bin Norjoharuddeen, E. Brücken, F. Garcia, P. Inkaew, K. T. S. Kallonen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M. m. Rantanen, H. Siikonen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, M. Kumar, V. Lohezic, J. Malcles, F. Orlandi, L. Portales, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, F. Beaudette, G. Boldrini, P. Busson, A. Cappati, C. Charlot, M. Chiusi, F. Damas, O. Davignon, A. De Wit, I. T. Ehle, B. A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, M. Nguyen, C. Ochando, R. Salerno, J. B. Sauvan, Y. Sirois, L. Urda Gómez, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, S. Falke, U. Goerlach, R. Haeberle, A.-C. Le Bihan, M. Meena, O. Poncet, G. Saha, M. A. Sessini, P. Van Hove, P. Vaucelle, A. Di Florio, D. Amram, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, E. Jourd‘huy, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, I. Bagaturia, I. Lomidze, Z. Tsamalaidze, V. Botta, S. Consuegra Rodríguez, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, D. Pérez Adán, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M. y. Lee, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, C. Seth, A. Sharma, J. L. Spah, A. Stein, F. Torres Da Silva De Araujo, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, J. Bach, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, F. Blekman, K. Borras, A. Campbell, A. Cardini, C. Cheng, F. Colombina, M. De Silva, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, V. Guglielmi, M. Guthoff, A. Hinzmann, L. Jeppe, B. Kaech, M. Kasemann, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, F. Lorkowski, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, A. B. Meyer, G. Milella, K. Moral Figueroa, A. Mussgiller, L. P. Nair, J. Niedziela, A. Nürnberg, Y. Otarid, J. Park, E. Ranken, A. Raspereza, D. Rastorguev, J. Rübenach, L. Rygaard, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, K. Sharko, M. Shchedrolosiev, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, S. Bollweg, M. Bonanomi, P. Connor, K. El Morabit, Y. Fischer, E. Garutti, A. Grohsjean, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, C. c. Kuo, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, U. Elicabuk, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. 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Csanád, K. Farkas, A. Fehérkuti, M. M. A. Gadallah, Á. Kadlecsik, P. Major, G. Pásztor, G. I. Veres, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Molnar, Z. Szillasi, F. Nemes, T. Novak, S. Bansal, S. B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, K. Sandeep, T. Sheokand, J. B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B. C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, M. K. Saini, S. Saumya, S. Baradia, S. Barman, S. Bhattacharya, S. Das Gupta, S. Dutta, S. Sarkar, M. M. Ameen, P. K. Behera, S. C. Behera, G. Dash, P. Jana, P. Kalbhor, S. Kamble, J. R. Komaragiri, D. Kumar, P. R. Pujahari, N. R. Saha, A. K. Sikdar, R. K. Singh, P. Verma, S. Verma, A. Vijay, S. Dugad, G. B. Mohanty, B. Parida, M. Shelake, P. Suryadevara, A. Bala, S. Banerjee, R. M. Chatterjee, M. Guchait, Sh. Jain, A. Jaiswal, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, C. Kar, D. Maity, P. Mal, T. Mishra, V. K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, S. Nayak, K. Pal, P. Sadangi, S. K. Swain, S. Varghese, D. Vats, S. Acharya, A. Alpana, S. Dube, B. Gomber, P. Hazarika, B. Kansal, A. Laha, B. Sahu, S. Sharma, K. Y. Vaish, H. Bakhshiansohi, A. Jafari, M. Zeinali, S. Bashiri, S. Chenarani, S. M. Etesami, Y. Hosseini, M. Khakzad, E. Khazaie, M. Mohammadi Najafabadi, S. Tizchang, M. Felcini, M. Grunewald, M. Abbrescia, A. Colaleo, D. Creanza, B. D’Anzi, N. De Filippis, M. De Palma, W. Elmetenawee, L. Fiore, G. Iaselli, L. Longo, M. Louka, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, D. Ramos, A. Ranieri, L. Silvestris, F. M. Simone, Ü. Sözbilir, A. Stamerra, D. Troiano, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, C. Grandi, L. Guiducci, S. Lo Meo, M. Lorusso, L. Lunerti, S. Marcellini, G. Masetti, F. L. Navarria, G. Paggi, A. Perrotta, F. Primavera, A. M. Rossi, S. Rossi Tisbeni, T. Rovelli, G. P. Siroli, S. Costa, A. Di Mattia, A. Lapertosa, R. Potenza, A. Tricomi, C. Tuve, P. Assiouras, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, F. Brivio, F. Cetorelli, F. De Guio, M. E. Dinardo, P. Dini, S. Gennai, R. Gerosa, A. Ghezzi, P. Govoni, L. Guzzi, M. T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, S. Palluotto, D. Pedrini, A. Perego, B. S. Pinolini, G. Pizzati, S. Ragazzi, T. Tabarelli de Fatis, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, F. Fabozzi, A. O. M. Iorio, L. 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Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Malik, A. S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A. W. Jung, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, A. Wildridge, W. Xie, Y. Yao, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, I. Krommydas, W. Li, J. Lin, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, R. Taus, B. Chiarito, J. P. Chou, S. V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A. G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A. R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, H. Chung, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, G. Vorotnikov, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
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Beyond Standard Model ,Hadron-Hadron Scattering ,Particle and Resonance Production ,Photon Production ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract A search for a new charged particle X with mass between 0.3 and 2.0 TeV decaying to a W boson and a photon is presented, using proton-proton collision data at a center-of-mass energy of 13 TeV, collected by the CMS experiment and corresponding to an integrated luminosity of 138 fb −1. Particle X has electric charge ±1 and is assumed to have spin 0. The search is performed using the electron and muon decays of the W boson. No significant excess above the predicted background is observed. The upper limit at 95% confidence level on the product of the production cross section of the X and its branching fraction to a W boson and a photon is found to be 94 (137) fb for a 0.3 TeV resonance and 0.75 (0.81) fb for a 2.0 TeV resonance, for an X width-to-mass ratio of 0.01% (5%). This search presents the most stringent constraints to date on the existence of such resonances across the probed mass range. A statistical combination with an earlier study based on the hadronic decay mode of the W boson is also performed, and the upper limit at 95% confidence level for a 2.0 TeV resonance is reduced to 0.50 (0.63) fb for an X width-to-mass ratio of 0.01% (5%).
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- 2024
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188. Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology
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Lingchen Liu, Jia Zhang, Scott Wood, Felicity Newell, Conrad Leonard, Lambros T. Koufariotis, Katia Nones, Andrew J. Dalley, Haarika Chittoory, Farzad Bashirzadeh, Jung Hwa Son, Daniel Steinfort, Jonathan P. Williamson, Michael Bint, Carl Pahoff, Phan T. Nguyen, Scott Twaddell, David Arnold, Christopher Grainge, Peter T. Simpson, David Fielding, Nicola Waddell, and John V. Pearson
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Long read sequencing ,Somatic structural variants detection ,Benchmarking long read approaches ,Small cell lung cancer ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background Lung cancer is a heterogeneous disease and the primary cause of cancer-related mortality worldwide. Somatic mutations, including large structural variants, are important biomarkers in lung cancer for selecting targeted therapy. Genomic studies in lung cancer have been conducted using short-read sequencing. Emerging long-read sequencing technologies are a promising alternative to study somatic structural variants, however there is no current consensus on how to process data and call somatic events. In this study, we preformed whole genome sequencing of lung cancer and matched non-tumour samples using long and short read sequencing to comprehensively benchmark three sequence aligners and seven structural variant callers comprised of generic callers (SVIM, Sniffles2, DELLY in generic mode and cuteSV) and somatic callers (Severus, SAVANA, nanomonsv and DELLY in somatic modes). Results Different combinations of aligners and variant callers influenced somatic structural variant detection. The choice of caller had a significant influence on somatic structural variant detection in terms of variant type, size, sensitivity, and accuracy. The performance of each variant caller was assessed by comparing to somatic structural variants identified by short-read sequencing. When compared to somatic structural variants detected with short-read sequencing, more events were detected with long-read sequencing. The mean recall of somatic variant events identified by long-read sequencing was higher for the somatic callers (72%) than generic callers (53%). Among the somatic callers when using the minimap2 aligner, SAVANA and Severus achieved the highest recall at 79.5% and 79.25% respectively, followed by nanomonsv with a recall of 72.5%. Conclusion Long-read sequencing can identify somatic structural variants in clincal samples. The longer reads have the potential to improve our understanding of cancer development and inform personalized cancer treatment.
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- 2024
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189. Longitudinal Dispersion and Hyporheic Exchange of Neutrally Buoyant Microplastics in the Presence of Waves and Currents
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Merenchi Galappaththige Nipuni Odara, Devvan Waghajiani, George-Catalin Obersterescu, and Jonathan Pearson
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solute mixing ,streamwise dispersion ,hyporheic zone ,microplastics ,open-channel flow ,flume experiments ,Biology (General) ,QH301-705.5 ,Microbiology ,QR1-502 ,Biochemistry ,QD415-436 - Abstract
An experimental study was conducted to identify the behaviour of neutrally buoyant microplastics (specific density, 0.94) in different hydrodynamic conditions while focusing on combined wave–current conditions and the mixing across the hyporheic zone. For in-water-column microplastics, it was observed that the streamwise dispersion of neutrally buoyant microplastics is comparable to solute dye in both slow open-channel flow conditions and combined wave–current conditions. However, for in-bed microplastics, when compared to soluble tracers, the longer timespans associated with the hyporheic exchange process allowed the density effects to enhance the vertical exchange when compared to solutes.
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- 2024
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190. Opportunities and challenges for global food safety in advancing circular policies and practices in agrifood systems
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Andrew J. Pearson, Keya Mukherjee, Vittorio Fattori, and Markus Lipp
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Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Abstract Sustainable agrifood systems are needed to provide safe and nutritious food for the growing world’s population. To improve sustainability, transforming linear policies and practices in agrifood systems into circularity will be critical, with food safety considerations key for the success of this shift. This review provides a synthesis of the current and emerging risks, data gaps, and opportunities for food safety in agrifood initiatives aiming to advance circular economy models.
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- 2024
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191. Punk Revolution! An Oral History of Punk Rock Politics and Activism by John Malkin (review)
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Pearson, David
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- 2024
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192. Search for new physics in high-mass diphoton events from proton-proton collisions at s $$ \sqrt{\textrm{s}} $$ = 13 TeV
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Carrera Jarrin, Y. Assran, B. El-mahdy, S. Elgammal, M. A. Mahmoud, Y. Mohammed, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, N. Bin Norjoharuddeen, E. Brücken, F. Garcia, P. Inkaew, K. T. S. Kallonen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M. m. Rantanen, H. Siikonen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, M. Kumar, V. Lohezic, J. Malcles, F. Orlandi, L. Portales, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, F. Beaudette, G. Boldrini, P. Busson, A. Cappati, C. Charlot, M. Chiusi, F. Damas, O. Davignon, A. De Wit, I. T. Ehle, B. A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, M. Nguyen, C. Ochando, R. Salerno, J. B. Sauvan, Y. Sirois, L. Urda Gómez, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, S. Falke, U. Goerlach, R. Haeberle, A.-C. Le Bihan, M. Meena, O. Poncet, G. Saha, M. A. Sessini, P. Van Hove, P. Vaucelle, A. Di Florio, D. Amram, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, E. Jourd‘huy, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, I. Lomidze, T. Toriashvili, Z. Tsamalaidze, V. Botta, S. Consuegra Rodríguez, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, D. Pérez Adán, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M. y. Lee, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, A. Sharma, J. L. Spah, A. Stein, F. Torres Da Silva De Araujo, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, J. Bach, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, A. Campbell, A. Cardini, C. Cheng, F. Colombina, M. De Silva, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, V. Guglielmi, M. Guthoff, A. Hinzmann, L. Jeppe, B. Kaech, M. Kasemann, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, F. Lorkowski, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, A. B. Meyer, G. Milella, K. Moral Figueroa, A. Mussgiller, L. P. Nair, J. Niedziela, A. Nürnberg, Y. Otarid, J. Park, E. Ranken, A. Raspereza, D. Rastorguev, J. Rübenach, L. Rygaard, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, K. Sharko, M. Shchedrolosiev, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, S. Bollweg, M. Bonanomi, P. Connor, K. El Morabit, Y. Fischer, E. Garutti, A. Grohsjean, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, C. c. Kuo, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J. M. Lawhorn, M. Link, A. Lintuluoto, B. Maier, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, E. Pfeffer, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H. J. Simonis, L. Sowa, L. Stockmeier, K. Tauqeer, M. Toms, N. Trevisani, R. F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, X. Zuo, G. Anagnostou, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, Z. Painesis, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, C. Hajdu, D. Horvath, K. Márton, A. J. Rádl, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, A. 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Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, S. Norberg, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, M. Safdari, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, P. Chang, V. Cherepanov, R. D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, S. Rosenzweig, Y. Takahashi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R. S. Kim, T. Kolberg, G. Martinez, H. Prosper, P. R. Prova, M. Wulansatiti, R. Yohay, B. Alsufyani, M. M. Baarmand, S. Butalla, S. Das, T. Elkafrawy, M. Hohlmann, M. Rahmani, E. Yanes, M. R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C. E. Gerber, M. Hawksworth, A. Hingrajiya, D. J. Hofman, J. h. Lee, D. S. Lemos, A. H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, E. Prifti, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, M. A. Wadud, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, S. Arteaga Escatel, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, J. Natoli, D. Roy, G. Sorrentino, A. Baden, A. Belloni, J. Bistany-riebman, Y. M. Chen, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, B. Kronheim, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M. M. Paranjpe, L. Wang, J. Bendavid, I. A. Cali, P. c. Chou, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mcginn, A. Novak, C. Paus, C. Roland, G. Roland, S. Rothman, G. S. F. Stephans, B. Wyslouch, T. J. Yang, B. Crossman, B. M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, M. Revering, R. Rusack, R. Saradhy, N. Strobbe, K. Bloom, D. R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J. E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, H. w. Hsia, I. Iashvili, A. Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, S. Malik, A. S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A. W. Jung, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, J. Lin, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, B. Chiarito, J. P. Chou, S. V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A. G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A. R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, G. Vorotnikov, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
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Beyond Standard Model ,Hadron-Hadron Scattering ,Photon Production ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Results are presented from a search for new physics in high-mass diphoton events from proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV. The data set was collected in 2016–2018 with the CMS detector at the LHC and corresponds to an integrated luminosity of 138 fb −1. Events with a diphoton invariant mass greater than 500 GeV are considered. Two different techniques are used to predict the standard model backgrounds: parametric fits to the smoothly-falling background and a first-principles calculation of the standard model diphoton spectrum at next-to-next-to-leading order in perturbative quantum chromodynamics calculations. The first technique is sensitive to resonant excesses while the second technique can identify broad differences in the invariant mass shape. The data are used to constrain the production of heavy Higgs bosons, Randall-Sundrum gravitons, the large extra dimensions model of Arkani-Hamed, Dimopoulos, and Dvali (ADD), and the continuum clockwork mechanism. No statistically significant excess is observed. The present results are the strongest limits to date on ADD extra dimensions and RS gravitons with a coupling parameter greater than 0.1.
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- 2024
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193. Factors influencing customers’ intention to adopt e-banking: a TAM and cybercrime perspective using structural equation modelling
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Byrne Kaulu, Goodwell Kaulu, and Pearson Chilongo
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E-banking ,Adoption intentions ,Technology acceptance model ,Structural equation modelling ,Cybercrime ,Perceived usefulness ,Finance ,HG1-9999 ,Business ,HF5001-6182 - Abstract
Purpose – This study assesses the factors influencing customers’ intention to adopt e-banking in the context of the technology acceptance model and the moderation role of cybercrime. Design/methodology/approach – The variables in the study are measured using a five-point Likert scale with measures adopted from existing literature. The independent variables are perceived ease of use, perceived usefulness and security and privacy. These are postulated to be moderated by the perceived risk of cybercrime and to influence e-banking adoption intentions. A quantitative approach is used. Primary data are collected from a sample of 209 randomly selected bank customers. The study uses a two-step (measurement model and structural model) approach to data analysis. Findings – The key findings in this study are that perceived risk of cybercrime strengthens the positive relationship between perceived ease of use and e-banking adoption intentions but dampens or weakens the positive relationship between perceived usefulness and customers’ e-banking adoption intentions. The study makes several recommendations to inform scholarship, policy and practice. Originality/value – Unlike existing literature, the study makes a unique contribution by including perceived risk of cybercrime as a moderating variable of theoretical significance in the relationship between adoption of e-banking and its determinants.
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- 2024
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194. APPROACH e-PROM system: a user-centered development and evaluation of an electronic patient-reported outcomes measurement system for management of coronary artery disease
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Andrew Roberts, Eleanor Benterud, Maria J. Santana, Jordan Engbers, Christine Lorenz, Nancy Verdin, Winnie Pearson, Peter Edgar, Joel Adekanye, Pantea Javaheri, Courtney E. MacDonald, Sarah Simmons, Sandra Zelinsky, Jeff Caird, Rick Sawatzky, Bryan Har, William A. Ghali, Colleen M. Norris, Michelle M. Graham, Matthew T. James, Stephen B. Wilton, Tolulope T. Sajobi, and for the APPROACH investigators
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Electronic patient-reported outcomes ,Usability evaluation ,Heuristic evaluation ,Coronary artery disease ,Patient engagement ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Coronary artery disease (CAD) confers increased risks of premature mortality, non-fatal morbidity, and significant impairment in functional status and health-related quality of life. Routine administration of electronic patient-reported outcome measures (PROMs) and its real time delivery to care providers is known to have the potential to inform routine cardiac care and to improve quality of care and patient outcomes. This study describes a user-centered development and evaluation of the Alberta Provincial Project for Outcomes Assessment (APPROACH) electronic Patient Reported Outcomes Measurement (e-PROM) system. This e-PROM system is an electronic system for the administration of PROMs to patients with CAD and the delivery of the summarized information to their care providers to facilitate patient-physician communication and shared decision-making. This electronic platform was designed to be accessible via web-based and hand-held devices. Heuristic and user acceptance evaluation were conducted with patients and attending care providers. Results The APPROACH e-PROM system was co-developed with patients and care providers, research investigators, informaticians and information technology experts. Five PROMs were selected for inclusion in the online platform after consultations with patient partners, care providers, and PROMs experts: the Seattle Angina Questionnaire, Patient Health Questionnaire, EuroQOL, and Medical Outcomes Study Social Support Survey, and Self-Care of Coronary Heart Disease Inventory. The heuristic evaluation was completed by four design experts who examined the usability of the prototype interfaces. User acceptance testing was completed with 13 patients and 10 cardiologists who evaluated prototype user interfaces of the e-PROM system. Conclusion Both patients and physicians found the APPROACH e-PROM system to be easy to use, understandable, and acceptable. The APPROACH e-PROM system provides a user-informed electronic platform designed to incorporate PROMs into the delivery of individualized cardiac care for persons with CAD.
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- 2024
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195. No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks
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Nathaniel M. Pearson and John Novembre
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ACE2 ,COVID ,COVID19 ,Functional prediction ,GWAS ,Host genetics ,Medicine - Abstract
Abstract Early in the SARS-CoV2 pandemic, in this journal, Hou et al. (BMC Med 18:216, 2020) interpreted public genotype data, run through functional prediction tools, as suggesting that members of particular human populations carry potentially COVID-risk-increasing variants in genes ACE2 and TMPRSS2 far more often than do members of other populations. Beyond resting on predictions rather than clinical outcomes, and focusing on variants too rare to typify population members even jointly, their claim mistook a well known artifact (that large samples reveal more of a population’s variants than do small samples) as if showing real and congruent population differences for the two genes, rather than lopsided population sampling in their shared source data. We explain that artifact, and contrast it with empirical findings, now ample, that other loci shape personal COVID risks far more significantly than do ACE2 and TMPRSS2—and that variation in ACE2 and TMPRSS2 per se unlikely exacerbates any net population disparity in the effects of such more risk-informative loci.
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- 2024
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196. Increases in housing rules and surveillance during COVID-19: impacts on overdose and overdose response in a community-based cohort of sex workers who use drugs in Vancouver, BC
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Jenn McDermid, Jennie Pearson, Melissa Braschel, Sarah Moreheart, Rory Marck, Kate Shannon, Andrea Krüsi, and Shira M. Goldenberg
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Surveillance ,Housing ,Criminalization ,Gender ,Sex work ,Drug use ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Introduction Since the beginning of the COVID-19 pandemic, COVID-19 risk mitigation measures have expanded to include increased rules and surveillance in supportive housing. Yet, in the context of the dual public health emergencies of COVID-19 and the unregulated drug toxicity crisis, we have not evaluated the unintended health and social consequences of such measures, especially on criminalized women. In order to address this dearth of evidence, our aim was to assess the association between increased housing rules and surveillance during COVID-19 and (a) nonfatal overdose, and (b) administration of naloxone for overdose reversal among women sex workers who use drugs in Vancouver, BC. Methods This study is nested within An Evaluation of Sex Workers Health Access (AESHA), a community-based prospective cohort of women sex workers in Metro Vancouver (2010–present). Using cross-sectional data collected during the first year of COVID-19 (April 2020–2021), we developed separate multivariable logistic regression confounder models to examine the independent associations between experiencing increased housing rules and surveillance during COVID-19 on (a) nonfatal overdose, and (b) administration of naloxone for overdose reversal in the last 6 months. Results Amongst 166 participants, 10.8% reported experiencing a recent non-fatal overdose and 31.3% recently administered naloxone for overdose reversal. 56.6% reported experiencing increased rules and surveillance within their housing during COVID-19. The prevalence of non-fatal overdose and administering naloxone was significantly elevated among those exposed to increased housing rules and surveillance during COVID-19 versus those who were unexposed (83.3% vs. 52.1%; 75.0% vs. 48.2%, respectively). In separate multivariate confounder models, exposure to increased housing rules and surveillance during COVID-19 was independently associated with increased odds of administering naloxone [AOR: 3.66, CI: 1.63–8.21], and marginally associated with non-fatal overdose [AOR: 3.49, CI: 0.92–13.27]. Conclusion Efforts to prioritize the right to safe, adequate and affordable housing must avoid reinforcing an overly coercive reliance on surveillance measures which, while often well-intended, can negatively shape residents’ well-being. Furthermore, public health responses to pandemics must include criminalized populations so that measures do not exacerbate overdose risk. Implementation of a regulated drug supply is recommended, alongside housing policies that promote residents' rights, safety, and health.
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- 2024
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197. Integration of patient and public involvement in a doctoral research study using the research cycle
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Helen Pearson, Carol Bell, Karl Cox, Catherine Kayum, Leona Knox, Faith Gibson, Michelle Myall, Anne-Sophie Darlington, Emma Potter, and Nicholas Bird
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Childhood cancer ,Co-design ,Co-production ,Decision-making ,Inclusion ,Paediatric ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Background Patient and public involvement (PPI) in research is widely acknowledged as essential to achieving successful and impactful research. Despite this acknowledgement, there are limited reports on how to approach and apply meaningful PPI throughout the research cycle and how to address challenges for researchers such as doctoral students, particularly when undertaking research on sensitive topics. This paper provides insights and examples for researchers new to PPI, on the impact of active PPI and recommendations for building and developing a PPI group in a paediatric focused doctoral research study with bereaved parents and carers. Methods PPI was informed by the research cycle. The GRIPP2 short-form checklist was used to report PPI. The research was funded by the National Institute for Health and Care Research. Results PPI enhanced the research through input into the study design, recruitment, co-design of the study website and branding; and ethics amendments to increase participation in response to the COVID-19 pandemic. The literature review was extended to incorporate a PPI consultation phase and members contributed to data analysis. A flexible approach enabled involvement to develop iteratively throughout the research study, resulting in changes being made to enhance the study design and outcomes. Conclusion This paper contributes to the limited knowledge base on embedding PPI into a doctoral research study and within the paediatric setting specifically working in partnership with bereaved parents and carers. Employing an adaptive approach to meet individual PPI needs, building a trusting and respectful partnership, creating shared ownership and investment in the research, are essential components to successful PPI.
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- 2024
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198. Disentangling gender and social difference for just and transformative biocultural approaches
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Isabel Díaz‐Reviriego, Mario Torralba, Beatriz Vizuete, Stefan Ortiz‐Przychodzka, Jasmine Pearson, Claudia Heindorf, Aymara LLanque Zonta, and Elisa Oteros‐Rozas
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environmental justice ,feminist approaches ,indigenous and local knowledge ,intersectionality ,non‐humans ,power relations ,Human ecology. Anthropogeography ,GF1-900 ,Ecology ,QH540-549.5 - Abstract
Abstract Advancing research and practice that recognize diverse worldviews, knowledge systems, and value orientations is essential to enable transformative change towards sustainability. Biocultural approaches recognize the diverse ways in which people relate to nature, offering a potential pathway for sustainability transformations. However, recent scholarship on biocultural approaches to sustainability has highlighted that social aspects such as equity and justice have not been substantively addressed, whereby gender issues have been overlooked to a great extent. Through qualitative content analysis, this review synthesizes the conceptualizations of gender and social difference within the literature on biocultural approaches to sustainability published in English and Spanish. The biocultural literature predominantly focuses on describing knowledge and management practices, neglecting power and gender relations that affect access and control over resources, and how different axes of social difference matter across different social‐ecological contexts. Overall, we found that gender considerations within the literature reviewed do not build upon feminist and gender theories. Based on these findings, we provide insights into how more nuanced engagements, especially in relation to feminist theories and tools as intersectionality and decolonial perspectives, can allow for more just scholarly efforts to address biocultural relations. Finally, we draw attention to responsible and engaged praxis towards promoting biocultural approaches that include the diverse perspectives of those who can contribute to transformative change, and which prevent the reinforcement of gender‐based power relations. Read the free Plain Language Summary for this article on the Journal blog.
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- 2024
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199. Single-arm, first-in-human feasibility study results for an ultra-low-cost insulin pump
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Matthew Payne, Francis Pooke, Tom M. Wilkinson, Lui Holder-Pearson, Bronté Chamberlain, Martin de Bock, and J. Geoffrey Chase
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Insulin pump ,Open-source ,Low-cost ,Clinical trial ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background Use of Continuous Subcutaneous Insulin Infusion (CSII) has been shown to improve glycemic outcomes in Type 1 Diabetes (T1D), but high costs limit accessibility. To address this issue, an inter-operable, open-source Ultra-Low-Cost Insulin Pump (ULCIP) was developed and previously shown to demonstrate comparable delivery accuracy to commercial models in standardised laboratory tests. This study aims to evaluate the updated ULCIP in-vivo, assessing its viability as an affordable alternative for those who cannot afford commercially available devices. Methods This first-in-human feasibility study recruited six participants with T1D. During a nine-hour inpatient stay, participants used the ULCIP under clinical supervision. Venous glucose, insulin, and β-Hydroxybutyrate were monitored to assess device performance. Results Participants displayed expected blood glucose and blood insulin levels in response to programmed basal and bolus insulin dosing. One participant developed mild ketosis, which was treated and did not recur when a new pump reservoir was placed. All other participants maintained β-Hydroxybutyrate
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- 2024
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200. PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI
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Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, and Joseph Ojo
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Chronic neuroinflammation and microglial activation are key mediators of the secondary injury cascades and cognitive impairment that follow exposure to repetitive mild traumatic brain injury (r-mTBI). Peroxisome proliferator-activated receptor-γ (PPARγ) is expressed on microglia and brain resident myeloid cell types and their signaling plays a major anti-inflammatory role in modulating microglial responses. At chronic timepoints following injury, constitutive PPARγ signaling is thought to be dysregulated, thus releasing the inhibitory brakes on chronically activated microglia. Increasing evidence suggests that thiazolidinediones (TZDs), a class of compounds approved from the treatment of diabetes mellitus, effectively reduce neuroinflammation and chronic microglial activation by activating the peroxisome proliferator-activated receptor-γ (PPARγ). The present study used a closed-head r-mTBI model to investigate the influence of the TZD Pioglitazone on cognitive function and neuroinflammation in the aftermath of r-mTBI exposure. We revealed that Pioglitazone treatment attenuated spatial learning and memory impairments at 6 months post-injury and reduced the expression of reactive microglia and astrocyte markers in the cortex, hippocampus, and corpus callosum. We then examined whether Pioglitazone treatment altered inflammatory signaling mechanisms in isolated microglia and confirmed downregulation of proinflammatory transcription factors and cytokine levels. To further investigate microglial-specific mechanisms underlying PPARγ-mediated neuroprotection, we generated a novel tamoxifen-inducible microglial-specific PPARγ overexpression mouse line and examined its influence on microglial phenotype following injury. Using RNA sequencing, we revealed that PPARγ overexpression ameliorates microglial activation, promotes the activation of pathways associated with wound healing and tissue repair (such as: IL10, IL4 and NGF pathways), and inhibits the adoption of a disease-associated microglia-like (DAM-like) phenotype. This study provides insight into the role of PPARγ as a critical regulator of the neuroinflammatory cascade that follows r-mTBI in mice and demonstrates that the use of PPARγ agonists such as Pioglitazone and newer generation TZDs hold strong therapeutic potential to prevent the chronic neurodegenerative sequelae of r-mTBI.
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- 2024
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