104,658 results on '"Pau A"'
Search Results
152. Transcutaneous bilirubin reliability during and after phototherapy depending on skin color
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Candel-Pau, Júlia, Maya-Enero, Silvia, Garcia-Garcia, Jordi, Duran-Jordà, Xavier, and López-Vílchez, María Ángeles
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- 2024
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153. A novel exploratory hybrid deep neural network to predict breast cancer for mammography based on wavelet features
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Karthiga, Rengarajan, Narasimhan, Kumaravelu, Chinthaginjala, Ravikumar, Anbazhagan, Rajesh, Chinnusamy, Manikandan, Pau, Giovanni, Satish, Kumar, Amirtharajan, Rengarajan, and Abbas, Mohamed
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- 2024
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154. Geometric overlapping coefficients for calculating the required emitters per plant in drip irrigation
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Martí, Pau, González-Altozano, Pablo, Gasque, María, Turégano, José-Vicente, and Royuela, Álvaro
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- 2024
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155. Transgenerational expression profiles of a sex related and an epigenetic control gene in the rotifer Brachionus plicatilis in relation to environmental predictability
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Colinas, Noemi, Montero-Pau, Javier, Carmona, María José, Sabatino, Raffaella, Di Cesare, Andrea, Eckert, Ester Maria, and García-Roger, Eduardo M.
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- 2024
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156. Development of reproductive barriers in sympatry
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Jezkova, Ivana, Montero-Pau, Javier, Ortells, Raquel, and Serra, Manuel
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- 2024
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157. Photocatalytic doping of organic semiconductors
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Jin, Wenlong, Yang, Chi-Yuan, Pau, Riccardo, Wang, Qingqing, Tekelenburg, Eelco K., Wu, Han-Yan, Wu, Ziang, Jeong, Sang Young, Pitzalis, Federico, Liu, Tiefeng, He, Qiao, Li, Qifan, Huang, Jun-Da, Kroon, Renee, Heeney, Martin, Woo, Han Young, Mura, Andrea, Motta, Alessandro, Facchetti, Antonio, Fahlman, Mats, Loi, Maria Antonietta, and Fabiano, Simone
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- 2024
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158. Hsp70 Knockdown in the Brine Shrimp Artemia franciscana: Implication on Reproduction, Immune Response and Embryonic Cuticular Structure
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Tiong, Irene K. R., Lau, Cher Chien, Sorgeloos, Patrick, Mat Taib, Mimi Iryani, Muhammad, Tengku Sifzizul Tengku, Danish-Daniel, Muhd, Tan, Min Pau, Sui, Liying, Wang, Min, and Sung, Yeong Yik
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- 2024
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159. The Versatility of Mixed Lignocellulose Feedstocks for Bioethanol Production: an Experimental Study and Empirical Prediction
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Cheenkachorn, Kraipat, Mensah, Richard Q., Dharmalingam, Babu, Gundupalli, Marttin Paulraj, Rattanaporn, Kittipong, Tantayotai, Prapakorn, Show, Pau Loke, and Sriariyanun, Malinee
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- 2024
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160. Biogas Production Through Mono- and Co-digestion of Pineapple Waste and Cow Dung at Different Substrate Ratios
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Hamzah, Adila Fazliyana Aili, Hamzah, Muhammad Hazwan, Man, Hasfalina Che, Jamali, Nur Syakina, Siajam, Shamsul Izhar, and Show, Pau Loke
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- 2024
- Full Text
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161. Non-linear instability of slowly rotating Kerr-AdS black holes
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Figueras, Pau and Rossi, Lorenzo
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
Generic scalar perturbations on a fixed slowly rotating Kerr-AdS black hole background exhibit stable trapping, that is, the scalar field remains in a region between the exterior of the black hole and the AdS boundary for a very long time, decaying only inverse logarithmically in time. We study this effect employing fully general simulations that take into account the non-linear backreaction of the scalar field on the geometry. We find that the stable trapping of generic perturbations of Kerr-AdS persists at the non-linear level. Furthermore, the spacetime settles into a time-dependant and non-axisymmetric black hole which differs from Kerr-AdS. Since our perturbations are generic, our results indicate that slowly rotating Kerr-AdS black holes are non-linearly unstable., Comment: v2: Major revision; includes new sections with new results
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- 2023
162. Continual Learning of Diffusion Models with Generative Distillation
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Masip, Sergi, Rodriguez, Pau, Tuytelaars, Tinne, and van de Ven, Gido M.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Diffusion models are powerful generative models that achieve state-of-the-art performance in image synthesis. However, training them demands substantial amounts of data and computational resources. Continual learning would allow for incrementally learning new tasks and accumulating knowledge, thus enabling the reuse of trained models for further learning. One potentially suitable continual learning approach is generative replay, where a copy of a generative model trained on previous tasks produces synthetic data that are interleaved with data from the current task. However, standard generative replay applied to diffusion models results in a catastrophic loss in denoising capabilities. In this paper, we propose generative distillation, an approach that distils the entire reverse process of a diffusion model. We demonstrate that our approach substantially improves the continual learning performance of generative replay with only a modest increase in the computational costs., Comment: To appear in the Proceedings of the Third Conference on Lifelong Learning Agents (CoLLAs), 2024
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- 2023
163. Exploring Emotion Expression Recognition in Older Adults Interacting with a Virtual Coach
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Palmero, Cristina, deVelasco, Mikel, Hmani, Mohamed Amine, Mtibaa, Aymen, Letaifa, Leila Ben, Buch-Cardona, Pau, Justo, Raquel, Amorese, Terry, González-Fraile, Eduardo, Fernández-Ruanova, Begoña, Tenorio-Laranga, Jofre, Johansen, Anna Torp, da Silva, Micaela Rodrigues, Martinussen, Liva Jenny, Korsnes, Maria Stylianou, Cordasco, Gennaro, Esposito, Anna, El-Yacoubi, Mounim A., Petrovska-Delacrétaz, Dijana, Torres, M. Inés, and Escalera, Sergio
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Human-Computer Interaction ,Computer Science - Machine Learning - Abstract
The EMPATHIC project aimed to design an emotionally expressive virtual coach capable of engaging healthy seniors to improve well-being and promote independent aging. One of the core aspects of the system is its human sensing capabilities, allowing for the perception of emotional states to provide a personalized experience. This paper outlines the development of the emotion expression recognition module of the virtual coach, encompassing data collection, annotation design, and a first methodological approach, all tailored to the project requirements. With the latter, we investigate the role of various modalities, individually and combined, for discrete emotion expression recognition in this context: speech from audio, and facial expressions, gaze, and head dynamics from video. The collected corpus includes users from Spain, France, and Norway, and was annotated separately for the audio and video channels with distinct emotional labels, allowing for a performance comparison across cultures and label types. Results confirm the informative power of the modalities studied for the emotional categories considered, with multimodal methods generally outperforming others (around 68% accuracy with audio labels and 72-74% with video labels). The findings are expected to contribute to the limited literature on emotion recognition applied to older adults in conversational human-machine interaction., Comment: This work has been submitted to the IEEE for possible publication
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- 2023
164. Race Against the Machine: a Fully-annotated, Open-design Dataset of Autonomous and Piloted High-speed Flight
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Bosello, Michael, Aguiari, Davide, Keuter, Yvo, Pallotta, Enrico, Kiade, Sara, Caminati, Gyordan, Pinzarrone, Flavio, Halepota, Junaid, Panerati, Jacopo, and Pau, Giovanni
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Computer Science - Robotics - Abstract
Unmanned aerial vehicles, and multi-rotors in particular, can now perform dexterous tasks in impervious environments, from infrastructure monitoring to emergency deliveries. Autonomous drone racing has emerged as an ideal benchmark to develop and evaluate these capabilities. Its challenges include accurate and robust visual-inertial odometry during aggressive maneuvers, complex aerodynamics, and constrained computational resources. As researchers increasingly channel their efforts into it, they also need the tools to timely and equitably compare their results and advances. With this dataset, we want to (i) support the development of new methods and (ii) establish quantitative comparisons for approaches originating from the broader robotics and artificial intelligence communities. We want to provide a one-stop resource that is comprehensive of (i) aggressive autonomous and piloted flight, (ii) high-resolution, high-frequency visual, inertial, and motion capture data, (iii) commands and control inputs, (iv) multiple light settings, and (v) corner-level labeling of drone racing gates. We also release the complete specifications to recreate our flight platform, using commercial off-the-shelf components and the open-source flight controller Betaflight, to democratize drone racing research. Our dataset, open-source scripts, and drone design are available at: https://github.com/tii-racing/drone-racing-dataset, Comment: 8 pages, 7 figures
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- 2023
165. Waveform Modelling for the Laser Interferometer Space Antenna
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LISA Consortium Waveform Working Group, Afshordi, Niayesh, Akçay, Sarp, Seoane, Pau Amaro, Antonelli, Andrea, Aurrekoetxea, Josu C., Barack, Leor, Barausse, Enrico, Benkel, Robert, Bernard, Laura, Bernuzzi, Sebastiano, Berti, Emanuele, Bonetti, Matteo, Bonga, Béatrice, Bozzola, Gabriele, Brito, Richard, Buonanno, Alessandra, Cárdenas-Avendaño, Alejandro, Casals, Marc, Chernoff, David F., Chua, Alvin J. K., Clough, Katy, Colleoni, Marta, Dhesi, Mekhi, Druart, Adrien, Durkan, Leanne, Faye, Guillaume, Ferguson, Deborah, Field, Scott E., Gabella, William E., García-Bellido, Juan, Gracia-Linares, Miguel, Gerosa, Davide, Green, Stephen R., Haney, Maria, Hannam, Mark, Heffernan, Anna, Hinderer, Tanja, Helfer, Thomas, Hughes, Scott A., Husa, Sascha, Isoyama, Soichiro, Katz, Michael L., Kavanagh, Chris, Khanna, Gaurav, Kidder, Larry E., Korol, Valeriya, Küchler, Lorenzo, Laguna, Pablo, Larrouturou, François, Tiec, Alexandre Le, Leather, Benjamin, Lim, Eugene A., Lim, Hyun, Littenberg, Tyson B., Long, Oliver, Lousto, Carlos O., Lovelace, Geoffrey, Lukes-Gerakopoulos, Georgios, Lynch, Philip, Macedo, Rodrigo P., Markakis, Charalampos, Maggio, Elisa, Mandel, Ilya, Maselli, Andrea, Mathews, Josh, Mourier, Pierre, Neilsen, David, Nagar, Alessandro, Nichols, David A., Novák, Jan, Okounkova, Maria, O'Shaughnessy, Richard, Oshita, Naritaka, O'Toole, Conor, Pan, Zhen, Pani, Paolo, Pappas, George, Paschalidis, Vasileios, Pfeiffer, Harald P., Pompili, Lorenzo, Pound, Adam, Pratten, Geraint, Rüter, Hannes R., Ruiz, Milton, Sam, Zeyd, Sberna, Laura, Shapiro, Stuart L., Shoemaker, Deirdre M., Sopuerta, Carlos F., Spiers, Andrew, Sundar, Hari, Tamanini, Nicola, Thompson, Jonathan E., Toubiana, Alexandre, Tsokaros, Antonios, Upton, Samuel D., van de Meent, Maarten, Vernieri, Daniele, Wachter, Jeremy M., Warburton, Niels, Wardell, Barry, Witek, Helvi, Witzany, Vojtěch, Yang, Huan, Zilhão, Miguel, Albertini, Angelica, Arun, K. G., Bezares, Miguel, Bonilla, Alexander, Chapman-Bird, Christian, Cownden, Bradley, Cunningham, Kevin, Devitt, Chris, Dolan, Sam, Duque, Francisco, Dyson, Conor, Fryer, Chris L., Gair, Jonathan R., Giacomazzo, Bruno, Gupta, Priti, Han, Wen-Biao, Haas, Roland, Hirschmann, Eric W., Huerta, E. A., Jetzer, Philippe, Kelly, Bernard, Khalil, Mohammed, Lewis, Jack, Lloyd-Ronning, Nicole, Marsat, Sylvain, Nardini, Germano, Neef, Jakob, Ottewill, Adrian, Pantelidou, Christiana, Piovano, Gabriel Andres, Redondo-Yuste, Jaime, Sagunski, Laura, Stein, Leo C., Skoupý, Viktor, Sperhake, Ulrich, Speri, Lorenzo, Spieksma, Thomas F. M., Stevens, Chris, Trestini, David, and Vañó-Viñuales, Alex
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
LISA, the Laser Interferometer Space Antenna, will usher in a new era in gravitational-wave astronomy. As the first anticipated space-based gravitational-wave detector, it will expand our view to the millihertz gravitational-wave sky, where a spectacular variety of interesting new sources abound: from millions of ultra-compact binaries in our Galaxy, to mergers of massive black holes at cosmological distances; from the beginnings of inspirals that will venture into the ground-based detectors' view to the death spiral of compact objects into massive black holes, and many sources in between. Central to realising LISA's discovery potential are waveform models, the theoretical and phenomenological predictions of the pattern of gravitational waves that these sources emit. This white paper is presented on behalf of the Waveform Working Group for the LISA Consortium. It provides a review of the current state of waveform models for LISA sources, and describes the significant challenges that must yet be overcome., Comment: 239 pages, 11 figures, white paper from the LISA Consortium Waveform Working Group, invited for submission to Living Reviews in Relativity, updated with comments from community
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- 2023
166. A robust shape model for blood vessels analysis
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Romero, Pau, Pedrós, Abel, Sebastian, Rafael, Lozano, Miguel, and García-Fernández, Ignacio
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Computer Science - Computational Engineering, Finance, and Science ,Physics - Medical Physics - Abstract
The availability of digital twins for the cardiovascular system will enable insightful computational tools both for research and clinical practice. This, however, demands robust and well defined models and methods for the different steps involved in the process. We present a vessel coordinate system (VCS) that enables the unanbiguous definition of locations in a vessel section, by adapting the idea of cylindrical coordinates to the vessel geometry. Using the VCS model, point correspondence can be defined among different samples of a cohort, allowing data transfer, quantitative comparison, shape coregistration or population analysis. Furthermore, the VCS model allows for the generation of specific meshes (e.g. cylindrical grids, ogrids) necessary for an accurate reconstruction of the geometries used in fluid simulations. We provide the technical details for coordinates computation and discuss the assumptions taken to guarantee that they are well defined. The VCS model is tested in a series of applications. We present a robust, low dimensional, patient specific vascular model and use it to study phenotype variability analysis of the thoracic aorta within a cohort of patients. Point correspondence is exploited to build an haemodynamics atlas of the aorta for the same cohort. The atlas originates from fluid simulations (Navier-Stokes with Finite Volume Method) conducted using OpenFOAMv10. We finally present a relevant discussion on the VCS model, which covers its impact in important areas such as shape modeling and computer fluids dynamics (CFD).
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- 2023
167. OC-NMN: Object-centric Compositional Neural Module Network for Generative Visual Analogical Reasoning
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Assouel, Rim, Rodriguez, Pau, Taslakian, Perouz, Vazquez, David, and Bengio, Yoshua
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Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
A key aspect of human intelligence is the ability to imagine -- composing learned concepts in novel ways -- to make sense of new scenarios. Such capacity is not yet attained for machine learning systems. In this work, in the context of visual reasoning, we show how modularity can be leveraged to derive a compositional data augmentation framework inspired by imagination. Our method, denoted Object-centric Compositional Neural Module Network (OC-NMN), decomposes visual generative reasoning tasks into a series of primitives applied to objects without using a domain-specific language. We show that our modular architectural choices can be used to generate new training tasks that lead to better out-of-distribution generalization. We compare our model to existing and new baselines in proposed visual reasoning benchmark that consists of applying arithmetic operations to MNIST digits.
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- 2023
168. Group Robust Classification Without Any Group Information
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Tsirigotis, Christos, Monteiro, Joao, Rodriguez, Pau, Vazquez, David, and Courville, Aaron
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Computer Science - Machine Learning - Abstract
Empirical risk minimization (ERM) is sensitive to spurious correlations in the training data, which poses a significant risk when deploying systems trained under this paradigm in high-stake applications. While the existing literature focuses on maximizing group-balanced or worst-group accuracy, estimating these accuracies is hindered by costly bias annotations. This study contends that current bias-unsupervised approaches to group robustness continue to rely on group information to achieve optimal performance. Firstly, these methods implicitly assume that all group combinations are represented during training. To illustrate this, we introduce a systematic generalization task on the MPI3D dataset and discover that current algorithms fail to improve the ERM baseline when combinations of observed attribute values are missing. Secondly, bias labels are still crucial for effective model selection, restricting the practicality of these methods in real-world scenarios. To address these limitations, we propose a revised methodology for training and validating debiased models in an entirely bias-unsupervised manner. We achieve this by employing pretrained self-supervised models to reliably extract bias information, which enables the integration of a logit adjustment training loss with our validation criterion. Our empirical analysis on synthetic and real-world tasks provides evidence that our approach overcomes the identified challenges and consistently enhances robust accuracy, attaining performance which is competitive with or outperforms that of state-of-the-art methods, which, conversely, rely on bias labels for validation., Comment: Accepted at the 37th Conference on Neural Information Processing Systems (NeurIPS 2023). Code is available at https://github.com/tsirif/uLA
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- 2023
169. A Survey on Transferability of Adversarial Examples across Deep Neural Networks
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Gu, Jindong, Jia, Xiaojun, de Jorge, Pau, Yu, Wenqain, Liu, Xinwei, Ma, Avery, Xun, Yuan, Hu, Anjun, Khakzar, Ashkan, Li, Zhijiang, Cao, Xiaochun, and Torr, Philip
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Computer Science - Computer Vision and Pattern Recognition - Abstract
The emergence of Deep Neural Networks (DNNs) has revolutionized various domains by enabling the resolution of complex tasks spanning image recognition, natural language processing, and scientific problem-solving. However, this progress has also brought to light a concerning vulnerability: adversarial examples. These crafted inputs, imperceptible to humans, can manipulate machine learning models into making erroneous predictions, raising concerns for safety-critical applications. An intriguing property of this phenomenon is the transferability of adversarial examples, where perturbations crafted for one model can deceive another, often with a different architecture. This intriguing property enables black-box attacks which circumvents the need for detailed knowledge of the target model. This survey explores the landscape of the adversarial transferability of adversarial examples. We categorize existing methodologies to enhance adversarial transferability and discuss the fundamental principles guiding each approach. While the predominant body of research primarily concentrates on image classification, we also extend our discussion to encompass other vision tasks and beyond. Challenges and opportunities are discussed, highlighting the importance of fortifying DNNs against adversarial vulnerabilities in an evolving landscape., Comment: Accepted to Transactions on Machine Learning Research (TMLR)
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- 2023
170. Deep machine learning for meteor monitoring: advances with transfer learning and gradient-weighted class activation mapping
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Peña-Asensio, Eloy, Trigo-Rodríguez, Josep M., Grèbol-Tomàs, Pau, Regordosa-Avellana, David, and Rimola, Albert
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
In recent decades, the use of optical detection systems for meteor studies has increased dramatically, resulting in huge amounts of data being analyzed. Automated meteor detection tools are essential for studying the continuous meteoroid incoming flux, recovering fresh meteorites, and achieving a better understanding of our Solar System. Concerning meteor detection, distinguishing false positives between meteor and non-meteor images has traditionally been performed by hand, which is significantly time-consuming. To address this issue, we developed a fully automated pipeline that uses Convolutional Neural Networks (CNNs) to classify candidate meteor detections. Our new method is able to detect meteors even in images that contain static elements such as clouds, the Moon, and buildings. To accurately locate the meteor within each frame, we employ the Gradient-weighted Class Activation Mapping (Grad-CAM) technique. This method facilitates the identification of the region of interest by multiplying the activations from the last convolutional layer with the average of the gradients across the feature map of that layer. By combining these findings with the activation map derived from the first convolutional layer, we effectively pinpoint the most probable pixel location of the meteor. We trained and evaluated our model on a large dataset collected by the Spanish Meteor Network (SPMN) and achieved a precision of 98\%. Our new methodology presented here has the potential to reduce the workload of meteor scientists and station operators and improve the accuracy of meteor tracking and classification., Comment: Accepted in Planetary and Space Science
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- 2023
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171. Robust multimodal models have outlier features and encode more concepts
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Crabbé, Jonathan, Rodríguez, Pau, Shankar, Vaishaal, Zappella, Luca, and Blaas, Arno
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
What distinguishes robust models from non-robust ones? This question has gained traction with the appearance of large-scale multimodal models, such as CLIP. These models have demonstrated unprecedented robustness with respect to natural distribution shifts. While it has been shown that such differences in robustness can be traced back to differences in training data, so far it is not known what that translates to in terms of what the model has learned. In this work, we bridge this gap by probing the representation spaces of 12 robust multimodal models with various backbones (ResNets and ViTs) and pretraining sets (OpenAI, LAION-400M, LAION-2B, YFCC15M, CC12M and DataComp). We find two signatures of robustness in the representation spaces of these models: (1) Robust models exhibit outlier features characterized by their activations, with some being several orders of magnitude above average. These outlier features induce privileged directions in the model's representation space. We demonstrate that these privileged directions explain most of the predictive power of the model by pruning up to $80 \%$ of the least important representation space directions without negative impacts on model accuracy and robustness; (2) Robust models encode substantially more concepts in their representation space. While this superposition of concepts allows robust models to store much information, it also results in highly polysemantic features, which makes their interpretation challenging. We discuss how these insights pave the way for future research in various fields, such as model pruning and mechanistic interpretability., Comment: 29 pages, 18 figures
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- 2023
172. The JWST Galactic Center Survey -- A White Paper
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Schoedel, Rainer, Longmore, Steve, Henshaw, Jonny, Ginsburg, Adam, Bally, John, Feldmeier, Anja, Hosek, Matt, Lara, Francisco Nogueras, Ciurlo, Anna, Chevance, Mélanie, Kruijssen, J. M. Diederik, Klessen, Ralf, Ponti, Gabriele, Amaro-Seoane, Pau, Anastasopoulou, Konstantina, Anderson, Jay, Arias, Maria, Barnes, Ashley T., Battersby, Cara, Bono, Giuseppe, Ferres, Lucía Bravo, Bryant, Aaron, Gonzáalez, Miguel Cano, Cassisi, Santi, Chaves-Velasquez, Leonardo, Conte, Francesco, Ramos, Rodrigo Contreras, Cotera, Angela, Crowe, Samuel, di Teodoro, Enrico, Do, Tuan, Eisenhauer, Frank, Enokiya, Rei, Fedriani, Rubén, Friske, Jennifer K. S., Gadotti, Dimitri, Gallart, Carme, Calvente, Teresa Gallego, Cano, Eulalia Gallego, Fuentes, Pablo García, Marín, Macarena García, Gardini, Angela, Gautam, Abhimat K., Ghez, Andrea, Gillessen, Stefan, Gouda, Naoteru, Gualandris, Alessia, Guarcello, Mario Giuseppe, Gutermuth, Robert, Haggard, Daryl, Hankins, Matthew, Hu, Yue, Kano, Ryohei, Kauffmann, Jens, Lau, Ryan, Lazarian, Alexandre, Libralato, Mattia, Lu, Anan, Lu, Xing, Lu, Jessica R., Luetzgendorf, Nora, Magorrian, John, Mandel, Shifra, Markoff, Sera, Arranz, Álvaro Martínez, Mastrobuono-Battisti, Alessandra, Melamed, Maria, Mills, Elisabeth, Mori, Kaya, Morris, Mark, Murchikova, Elena, Nagata, Tetsuya, Najarro, Francisco, Nandakumar, Govind, Nataf, David, Neumayer, Nadine, Nishiyama, Shogo, Nobukawa, Masayoshi, Paré, Dylan M, Peissker, Florian, Petkova, Maya, Pillai, Thushara G. S., Román, Mike Rich Carlos, Rugel, Michael, Ryde, Nils, Sabha, Nadeen, Bermúdez, Joel Sánchez, Sánchez-Monge, Álvaro, Schultheis, Mathias, Shao, Lijing, Shinnaga, Hiroko, Simpson, Janet, Takekawa, Shunya, Tan, Jonathan C., Thorsbro, Brian, Torne, Pablo, Tress, Robin Goppala, Uchiyam, Hideki, Valenti, Elena, van der Marel, Roeland, Verberne, Sill, Vermot, Pierre, von Fellenberg, Sebastiano, Walker, Daniel, Witzel, Gunther, Xu, Siyao, Yano, Taihei, Yusef-Zadeh, Farhad, Zajaček, Michal, and Zoccali, Manuela
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Astrophysics - Astrophysics of Galaxies - Abstract
The inner hundred parsecs of the Milky Way hosts the nearest supermassive black hole, largest reservoir of dense gas, greatest stellar density, hundreds of massive main and post main sequence stars, and the highest volume density of supernovae in the Galaxy. As the nearest environment in which it is possible to simultaneously observe many of the extreme processes shaping the Universe, it is one of the most well-studied regions in astrophysics. Due to its proximity, we can study the center of our Galaxy on scales down to a few hundred AU, a hundred times better than in similar Local Group galaxies and thousands of times better than in the nearest active galaxies. The Galactic Center (GC) is therefore of outstanding astrophysical interest. However, in spite of intense observational work over the past decades, there are still fundamental things unknown about the GC. JWST has the unique capability to provide us with the necessary, game-changing data. In this White Paper, we advocate for a JWST NIRCam survey that aims at solving central questions, that we have identified as a community: i) the 3D structure and kinematics of gas and stars; ii) ancient star formation and its relation with the overall history of the Milky Way, as well as recent star formation and its implications for the overall energetics of our galaxy's nucleus; and iii) the (non-)universality of star formation and the stellar initial mass function. We advocate for a large-area, multi-epoch, multi-wavelength NIRCam survey of the inner 100\,pc of the Galaxy in the form of a Treasury GO JWST Large Program that is open to the community. We describe how this survey will derive the physical and kinematic properties of ~10,000,000 stars, how this will solve the key unknowns and provide a valuable resource for the community with long-lasting legacy value., Comment: This White Paper will be updated when required (e.g. new authors joining, editing of content). Most recent update: 24 Oct 2023
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- 2023
173. The look of high-velocity red-giant star collisions
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Dessart, Luc, Ryu, Taeho, Seoane, Pau Amaro, and Taylor, Andrew M.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
High-velocity stellar collisions driven by a supermassive black hole (BH) or BH-driven disruptive collisions, in dense, nuclear clusters can rival the energetics of supergiant star explosions following gravitational collapse of their iron core. Here, starting from a sample of red-giant star collisions simulated with the hydrodynamics code AREPO, we generate photometric and spectroscopic observables using the nonlocal thermodynamic equilibrium time-dependent radiative transfer code CMFGEN. Collisions from more extended giants or stronger collisions (higher velocity or smaller impact parameter) yield bolometric luminosities on the order of 1e43 erg/s at 1d, evolving on a timescale of a week to a bright plateau at ~1e41 erg/s, before plunging precipitously after 20-40d at the end of the optically-thick phase. This luminosity falls primarily in the UV in the first days, thus when it is at its maximum, and shifts to the optical thereafter. Collisions at lower velocity or from less extended stars produce ejecta that are fainter but may remain optically thick for up to 40d if they have a small expansion rate. These collision debris show a similar spectral evolution as that observed or modeled for blue-supergiant star explosions of massive stars, differing only in the more rapid transition to the nebular phase. Such BH-driven disruptive collisions should be detectable by high-cadence surveys in the UV like ULTRASAT., Comment: submitted to A&A
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- 2023
174. Optimization-based frequentist confidence intervals for functionals in constrained inverse problems: Resolving the Burrus conjecture
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Batlle, Pau, Patil, Pratik, Stanley, Michael, Owhadi, Houman, and Kuusela, Mikael
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Mathematics - Statistics Theory ,Statistics - Methodology - Abstract
We present an optimization-based framework to construct confidence intervals for functionals in constrained inverse problems, ensuring valid one-at-a-time frequentist coverage guarantees. Our approach builds upon the now-called strict bounds intervals, originally pioneered by Burrus (1965) and Rust and Burrus (1972), which offer ways to directly incorporate any side information about the parameters during inference without introducing external biases. This family of methods allows for uncertainty quantification in ill-posed inverse problems without needing to select a regularizing prior. By tying optimization-based intervals to an inversion of a constrained likelihood ratio test, we translate interval coverage guarantees into type I error control and characterize the resulting interval via solutions to optimization problems. Along the way, we refute the Burrus conjecture, which posited that, for possibly rank-deficient linear Gaussian models with positivity constraints, a correction based on the quantile of the chi-squared distribution with one degree of freedom suffices to shorten intervals while maintaining frequentist coverage guarantees. Our framework provides a novel approach to analyzing the conjecture, and we construct a counterexample employing a stochastic dominance argument, which we also use to disprove a general form of the conjecture. We illustrate our framework with several numerical examples and provide directions for extensions beyond the Rust-Burrus method for nonlinear, non-Gaussian settings with general constraints., Comment: 54 pages, V3: minor changes in related work and discussion
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- 2023
175. DeepPCR: Parallelizing Sequential Operations in Neural Networks
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Danieli, Federico, Sarabia, Miguel, Suau, Xavier, Rodríguez, Pau, and Zappella, Luca
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Computer Science - Machine Learning - Abstract
Parallelization techniques have become ubiquitous for accelerating inference and training of deep neural networks. Despite this, several operations are still performed in a sequential manner. For instance, the forward and backward passes are executed layer-by-layer, and the output of diffusion models is produced by applying a sequence of denoising steps. This sequential approach results in a computational cost proportional to the number of steps involved, presenting a potential bottleneck as the number of steps increases. In this work, we introduce DeepPCR, a novel algorithm which parallelizes typically sequential operations in order to speed up inference and training of neural networks. DeepPCR is based on interpreting a sequence of $L$ steps as the solution of a specific system of equations, which we recover using the Parallel Cyclic Reduction algorithm. This reduces the complexity of computing the sequential operations from $\mathcal{O}(L)$ to $\mathcal{O}(\log_2L)$, thus yielding a speedup for large $L$. To verify the theoretical lower complexity of the algorithm, and to identify regimes for speedup, we test the effectiveness of DeepPCR in parallelizing the forward and backward pass in multi-layer perceptrons, and reach speedups of up to $30\times$ for the forward and $200\times$ for the backward pass. We additionally showcase the flexibility of DeepPCR by parallelizing training of ResNets with as many as 1024 layers, and generation in diffusion models, enabling up to $7\times$ faster training and $11\times$ faster generation, respectively, when compared to the sequential approach.
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- 2023
176. Diagnosis of Helicobacter pylori using AutoEncoders for the Detection of Anomalous Staining Patterns in Immunohistochemistry Images
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Cano, Pau, Caravaca, Álvaro, Gil, Debora, and Musulen, Eva
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
This work addresses the detection of Helicobacter pylori a bacterium classified since 1994 as class 1 carcinogen to humans. By its highest specificity and sensitivity, the preferred diagnosis technique is the analysis of histological images with immunohistochemical staining, a process in which certain stained antibodies bind to antigens of the biological element of interest. This analysis is a time demanding task, which is currently done by an expert pathologist that visually inspects the digitized samples. We propose to use autoencoders to learn latent patterns of healthy tissue and detect H. pylori as an anomaly in image staining. Unlike existing classification approaches, an autoencoder is able to learn patterns in an unsupervised manner (without the need of image annotations) with high performance. In particular, our model has an overall 91% of accuracy with 86\% sensitivity, 96% specificity and 0.97 AUC in the detection of H. pylori., Comment: 9 pages
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- 2023
177. Enumerating All Maximal Clique-Partitions of an Undirected Graph
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Marin, Mircea, Kutsia, Temur, Pau, Cleo, and Rukhaia, Mikheil
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Computer Science - Discrete Mathematics ,G2.1 ,G2.2 - Abstract
We address the problem of enumerating all maximal clique-partitions of an undirected graph and present an algorithm based on the observation that every maximal clique-partition can be produced from the maximal clique-cover of the graph by assigning the vertices shared among maximal cliques, to belong to only one clique. This simple algorithm has the following drawbacks: (1) the search space is very large; (2) it finds some clique-partitions which are not maximal; and (3) some clique-partitions are found more than once. We propose two criteria to avoid these drawbacks. The outcome is an algorithm that explores a much smaller search space and guarantees that every maximal clique-partition is computed only once. The algorithm can be used in problems such as anti-unification with proximity relations or in resource allocation tasks when one looks for several alternative ways to allocate resources., Comment: In Proceedings FROM 2023, arXiv:2309.12959
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- 2023
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178. Hungarian Qubit Assignment for Optimized Mapping of Quantum Circuits on Multi-Core Architectures
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Escofet, Pau, Ovide, Anabel, Almudever, Carmen G., Alarcón, Eduard, and Abadal, Sergi
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Quantum Physics - Abstract
Modular quantum computing architectures offer a promising alternative to monolithic designs for overcoming the scaling limitations of current quantum computers. To achieve scalability beyond small prototypes, quantum architectures are expected to adopt a modular approach, featuring clusters of tightly connected quantum bits with sparser connections between these clusters. Efficiently distributing qubits across multiple processing cores is critical for improving quantum computing systems' performance and scalability. To address this challenge, we propose the Hungarian Qubit Assignment (HQA) algorithm, which leverages the Hungarian algorithm to improve qubit-to-core assignment. The HQA algorithm considers the interactions between qubits over the entire circuit, enabling fine-grained partitioning and enhanced qubit utilization. We compare the HQA algorithm with state-of-the-art alternatives through comprehensive experiments using both real-world quantum algorithms and random quantum circuits. The results demonstrate the superiority of our proposed approach, outperforming existing methods, with an average improvement of 1.28$\times$.
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- 2023
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179. Interconnect Fabrics for Multi-Core Quantum Processors: A Context Analysis
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Escofet, Pau, Rached, Sahar Ben, Rodrigo, Santiago, Almudever, Carmen G., Alarcón, Eduard, and Abadal, Sergi
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Quantum Physics ,Computer Science - Emerging Technologies - Abstract
Quantum computing has revolutionized the field of computer science with its extraordinary ability to handle classically intractable problems. To realize its potential, however, quantum computers need to scale to millions of qubits, a feat that will require addressing fascinating yet extremely challenging interconnection problems. In this paper, we provide a context analysis of the nascent quantum computing field from the perspective of communications, with the aim of encouraging the on-chip networks community to contribute and pave the way for truly scalable quantum computers in the decades to come., Comment: 6 pages, 4 figures; appearing in Proceedings of the IEEE/ACM NoCArc 2023
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- 2023
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180. AI4Food-NutritionFW: A Novel Framework for the Automatic Synthesis and Analysis of Eating Behaviours
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Romero-Tapiador, Sergio, Tolosana, Ruben, Morales, Aythami, Espinosa-Salinas, Isabel, Freixer, Gala, Fierrez, Julian, Vera-Rodriguez, Ruben, Pau, Enrique Carrillo de Santa, de Molina, Ana Ramírez, and Ortega-Garcia, Javier
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Databases - Abstract
Nowadays millions of images are shared on social media and web platforms. In particular, many of them are food images taken from a smartphone over time, providing information related to the individual's diet. On the other hand, eating behaviours are directly related to some of the most prevalent diseases in the world. Exploiting recent advances in image processing and Artificial Intelligence (AI), this scenario represents an excellent opportunity to: i) create new methods that analyse the individuals' health from what they eat, and ii) develop personalised recommendations to improve nutrition and diet under specific circumstances (e.g., obesity or COVID). Having tunable tools for creating food image datasets that facilitate research in both lines is very much needed. This paper proposes AI4Food-NutritionFW, a framework for the creation of food image datasets according to configurable eating behaviours. AI4Food-NutritionFW simulates a user-friendly and widespread scenario where images are taken using a smartphone. In addition to the framework, we also provide and describe a unique food image dataset that includes 4,800 different weekly eating behaviours from 15 different profiles and 1,200 subjects. Specifically, we consider profiles that comply with actual lifestyles from healthy eating behaviours (according to established knowledge), variable profiles (e.g., eating out, holidays), to unhealthy ones (e.g., excess of fast food or sweets). Finally, we automatically evaluate a healthy index of the subject's eating behaviours using multidimensional metrics based on guidelines for healthy diets proposed by international organisations, achieving promising results (99.53% and 99.60% accuracy and sensitivity, respectively). We also release to the research community a software implementation of our proposed AI4Food-NutritionFW and the mentioned food image dataset created with it., Comment: 10 pages, 5 figures, 4 tables
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- 2023
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181. GRFolres: A code for modified gravity simulations in strong gravity
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Saló, Llibert Aresté, Brady, Sam E., Clough, Katy, Doneva, Daniela, Evstafyeva, Tamara, Figueras, Pau, França, Tiago, Rossi, Lorenzo, and Yao, Shunhui
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General Relativity and Quantum Cosmology ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
GRFolres is an open-source code for performing simulations in modified theories of gravity, based on the publicly available 3+1D numerical relativity code GRChombo. Note: Submitted for review in the Journal of Open Source Software; Comments welcome; The code can be found at https://github.com/GRChombo/GRFolres
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- 2023
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182. DBsurf: A Discrepancy Based Method for Discrete Stochastic Gradient Estimation
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Arabi, Pau Mulet, Flowers, Alec, Mauch, Lukas, and Cardinaux, Fabien
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Computer Science - Machine Learning ,I.2.0 - Abstract
Computing gradients of an expectation with respect to the distributional parameters of a discrete distribution is a problem arising in many fields of science and engineering. Typically, this problem is tackled using Reinforce, which frames the problem of gradient estimation as a Monte Carlo simulation. Unfortunately, the Reinforce estimator is especially sensitive to discrepancies between the true probability distribution and the drawn samples, a common issue in low sampling regimes that results in inaccurate gradient estimates. In this paper, we introduce DBsurf, a reinforce-based estimator for discrete distributions that uses a novel sampling procedure to reduce the discrepancy between the samples and the actual distribution. To assess the performance of our estimator, we subject it to a diverse set of tasks. Among existing estimators, DBsurf attains the lowest variance in a least squares problem commonly used in the literature for benchmarking. Furthermore, DBsurf achieves the best results for training variational auto-encoders (VAE) across different datasets and sampling setups. Finally, we apply DBsurf to build a simple and efficient Neural Architecture Search (NAS) algorithm with state-of-the-art performance., Comment: 22 pages, 7 figures
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- 2023
183. Coordination of shoot apical meristem shape and identity by APETALA2 during floral transition in Arabidopsis
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Bertran Garcia de Olalla, Enric, Cerise, Martina, Rodríguez-Maroto, Gabriel, Casanova-Ferrer, Pau, Vayssières, Alice, Severing, Edouard, López Sampere, Yaiza, Wang, Kang, Schäfer, Sabine, Formosa-Jordan, Pau, and Coupland, George
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- 2024
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184. Clostridium and Cryptosporidium outbreak linked to a splash pad
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de Andrés Aguayo, Anna, Millet, Joan-Pau, Álvarez-Bruned, Laia, Palma, David, Gómez, Anna, Gallés, Pau, Sabaté, Sara, Álvarez, Gabriela, Rodriguez, Virginia, Cornejo, Thais, and Rius, Cristina
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- 2024
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185. Prevalence of urinary incontinence and associated factors in nursing homes: a multicentre cross-sectional study
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Jerez-Roig, Javier, Farrés-Godayol, Pau, Yildirim, Meltem, Escribà-Salvans, Anna, Moreno-Martin, Pau, Goutan-Roura, Ester, Rierola-Fochs, Sandra, Romero-Mas, Montse, Booth, Joanne, Skelton, Dawn A., Giné-Garriga, Maria, and Minobes-Molina, Eduard
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- 2024
- Full Text
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186. Adherence and toxicity during the treatment of latent tuberculous infection in a referral center in Spain
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Ortiz, Juan David Puyana, Rodriguez, Andrea Carolina Garces, Aznar, Maria Luisa, Pereiro, Juan Espinosa, Sanchez-Montalva, Adrian, Martinez-Camprecios, Joan, Saborit, Nuria, Rodrigo-Pendas, Jose Angel, Salgado, Guadalupe Garcia, Cortes, Claudia Broto, Delcor, Nuria Serre, Oliveira, Ines, Maruri, Begona Trevino, Ciruelo, Diana Pou, Salvador, Fernando, Bosch-Nicolau, Pau, Torrecilla-Martinez, Irene, Zules-Ona, Ricardo, Fernandez, Maria Teresa Tortola, and Molina, Israel
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- 2023
187. Grass Evolutionary Lineages Can Be Identified Using Hyperspectral Leaf Reflectance
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Slapikas, Ryan, Pau, Stephanie, Donnelly, Ryan C, Ho, Che‐Ling, Nippert, Jesse B, Helliker, Brent R, Riley, William J, Still, Christopher J, and Griffith, Daniel M
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Earth Sciences ,Geoinformatics ,Life on Land ,grasslands ,hyperspectral ,imaging spectroscopy ,phylogenetic conservatism ,plant functional types ,Poaceae ,remote sensing ,Geophysics - Abstract
Abstract: Hyperspectral remote sensing has the potential to map numerous attributes of the Earth’s surface, including spatial patterns of biological diversity. Grasslands are one of the largest biomes on Earth. Accurate mapping of grassland biodiversity relies on spectral discrimination of endmembers of species or plant functional types. We focused on spectral separation of grass lineages that dominate global grassy biomes: Andropogoneae (C4), Chloridoideae (C4), and Pooideae (C3). We examined leaf reflectance spectra (350–2,500 nm) from 43 grass species representing these grass lineages from four representative grassland sites in the Great Plains region of North America. We assessed the utility of leaf reflectance data for classification of grass species into three major lineages and by collection site. Classifications had very high accuracy (94%) that were robust to site differences in species and environment. We also show an information loss using multispectral sensors, that is, classification accuracy of grass lineages using spectral bands provided by current multispectral satellites is much lower (accuracy of 85.2% and 61.3% using Sentinel 2 and Landsat 8 bands, respectively). Our results suggest that hyperspectral data have an exciting potential for mapping grass functional types as informed by phylogeny. Leaf‐level hyperspectral separability of grass lineages is consistent with the potential increase in biodiversity and functional information content from the next generation of satellite‐based spectrometers.
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- 2024
188. Seagrass genomes reveal ancient polyploidy and adaptations to the marine environment
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Ma, Xiao, Vanneste, Steffen, Chang, Jiyang, Ambrosino, Luca, Barry, Kerrie, Bayer, Till, Bobrov, Alexander A, Boston, LoriBeth, Campbell, Justin E, Chen, Hengchi, Chiusano, Maria Luisa, Dattolo, Emanuela, Grimwood, Jane, He, Guifen, Jenkins, Jerry, Khachaturyan, Marina, Marín-Guirao, Lázaro, Mesterházy, Attila, Muhd, Danish-Daniel, Pazzaglia, Jessica, Plott, Chris, Rajasekar, Shanmugam, Rombauts, Stephane, Ruocco, Miriam, Scott, Alison, Tan, Min Pau, Van de Velde, Jozefien, Vanholme, Bartel, Webber, Jenell, Wong, Li Lian, Yan, Mi, Sung, Yeong Yik, Novikova, Polina, Schmutz, Jeremy, Reusch, Thorsten BH, Procaccini, Gabriele, Olsen, Jeanine L, and Van de Peer, Yves
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Biological Sciences ,Ecology ,Genetics ,Life Below Water ,Climate Action ,Alismatales ,Zosteraceae ,Ecosystem ,Plant Biology ,Crop and Pasture Production ,Plant biology - Abstract
We present chromosome-level genome assemblies from representative species of three independently evolved seagrass lineages: Posidonia oceanica, Cymodocea nodosa, Thalassia testudinum and Zostera marina. We also include a draft genome of Potamogeton acutifolius, belonging to a freshwater sister lineage to Zosteraceae. All seagrass species share an ancient whole-genome triplication, while additional whole-genome duplications were uncovered for C. nodosa, Z. marina and P. acutifolius. Comparative analysis of selected gene families suggests that the transition from submerged-freshwater to submerged-marine environments mainly involved fine-tuning of multiple processes (such as osmoregulation, salinity, light capture, carbon acquisition and temperature) that all had to happen in parallel, probably explaining why adaptation to a marine lifestyle has been exceedingly rare. Major gene losses related to stomata, volatiles, defence and lignification are probably a consequence of the return to the sea rather than the cause of it. These new genomes will accelerate functional studies and solutions, as continuing losses of the 'savannahs of the sea' are of major concern in times of climate change and loss of biodiversity.
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- 2024
189. Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
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Wang, Hui, Chang, Timothy S, Dombroski, Beth A, Cheng, Po-Liang, Patil, Vishakha, Valiente-Banuet, Leopoldo, Farrell, Kurt, Mclean, Catriona, Molina-Porcel, Laura, Rajput, Alex, De Deyn, Peter Paul, Le Bastard, Nathalie, Gearing, Marla, Kaat, Laura Donker, Van Swieten, John C, Dopper, Elise, Ghetti, Bernardino F, Newell, Kathy L, Troakes, Claire, de Yébenes, Justo G, Rábano-Gutierrez, Alberto, Meller, Tina, Oertel, Wolfgang H, Respondek, Gesine, Stamelou, Maria, Arzberger, Thomas, Roeber, Sigrun, Müller, Ulrich, Hopfner, Franziska, Pastor, Pau, Brice, Alexis, Durr, Alexandra, Le Ber, Isabelle, Beach, Thomas G, Serrano, Geidy E, Hazrati, Lili-Naz, Litvan, Irene, Rademakers, Rosa, Ross, Owen A, Galasko, Douglas, Boxer, Adam L, Miller, Bruce L, Seeley, Willian W, Van Deerlin, Vivanna M, Lee, Edward B, White, Charles L, Morris, Huw, de Silva, Rohan, Crary, John F, Goate, Alison M, Friedman, Jeffrey S, Leung, Yuk Yee, Coppola, Giovanni, Naj, Adam C, Wang, Li-San, Dalgard, Clifton, Dickson, Dennis W, Höglinger, Günter U, Schellenberg, Gerard D, Geschwind, Daniel H, and Lee, Wan-Ping
- Subjects
Biological Sciences ,Genetics ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurodegenerative ,Acquired Cognitive Impairment ,Frontotemporal Dementia (FTD) ,Rare Diseases ,Neurosciences ,Dementia ,Human Genome ,Brain Disorders ,Biotechnology ,Aging ,Alzheimer's Disease Related Dementias (ADRD) ,Alzheimer's Disease ,2.1 Biological and endogenous factors ,Neurological ,Progressive Supranuclear Palsy ,Whole-Genome Sequencing ,Genome-Wide Association Study ,Structural Variants ,Apolipoprotein E ,P. S. P. genetics study group ,Humans ,Supranuclear Palsy ,Progressive ,Genetic Predisposition to Disease ,Polymorphism ,Single Nucleotide ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Whole Genome Sequencing ,Clinical Sciences ,Neurology & Neurosurgery ,Biochemistry and cell biology - Abstract
BackgroundProgressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP were based on genotype array, therefore, were inadequate for the analysis of rare variants as well as larger mutations, such as small insertions/deletions (indels) and structural variants (SVs).MethodIn this study, we performed whole genome sequencing (WGS) and conducted association analysis for single nucleotide variants (SNVs), indels, and SVs, in a cohort of 1,718 cases and 2,944 controls of European ancestry. Of the 1,718 PSP individuals, 1,441 were autopsy-confirmed and 277 were clinically diagnosed.ResultsOur analysis of common SNVs and indels confirmed known genetic loci at MAPT, MOBP, STX6, SLCO1A2, DUSP10, and SP1, and further uncovered novel signals in APOE, FCHO1/MAP1S, KIF13A, TRIM24, TNXB, and ELOVL1. Notably, in contrast to Alzheimer's disease (AD), we observed the APOE ε2 allele to be the risk allele in PSP. Analysis of rare SNVs and indels identified significant association in ZNF592 and further gene network analysis identified a module of neuronal genes dysregulated in PSP. Moreover, seven common SVs associated with PSP were observed in the H1/H2 haplotype region (17q21.31) and other loci, including IGH, PCMT1, CYP2A13, and SMCP. In the H1/H2 haplotype region, there is a burden of rare deletions and duplications (P = 6.73 × 10-3) in PSP.ConclusionsThrough WGS, we significantly enhanced our understanding of the genetic basis of PSP, providing new targets for exploring disease mechanisms and therapeutic interventions.
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- 2024
190. A few-shot learning method for tobacco abnormality identification.
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Lin, Hong, Qiang, Zhenping, Tse, Rita, Tang, Su-Kit, and Pau, Giovanni
- Subjects
cross-domain ,feature representation ,few-shot learning ,instance-embedding ,task-adaptation ,tobacco disease identification - Abstract
Tobacco is a valuable crop, but its disease identification is rarely involved in existing works. In this work, we use few-shot learning (FSL) to identify abnormalities in tobacco. FSL is a solution for the data deficiency that has been an obstacle to using deep learning. However, weak feature representation caused by limited data is still a challenging issue in FSL. The weak feature representation leads to weak generalization and troubles in cross-domain. In this work, we propose a feature representation enhancement network (FREN) that enhances the feature representation through instance embedding and task adaptation. For instance embedding, global max pooling, and global average pooling are used together for adding more features, and Gaussian-like calibration is used for normalizing the feature distribution. For task adaptation, self-attention is adopted for task contextualization. Given the absence of publicly available data on tobacco, we created a tobacco leaf abnormality dataset (TLA), which includes 16 categories, two settings, and 1,430 images in total. In experiments, we use PlantVillage, which is the benchmark dataset for plant disease identification, to validate the superiority of FREN first. Subsequently, we use the proposed method and TLA to analyze and discuss the abnormality identification of tobacco. For the multi-symptom diseases that always have low accuracy, we propose a solution by dividing the samples into subcategories created by symptom. For the 10 categories of tomato in PlantVillage, the accuracy achieves 66.04% in 5-way, 1-shot tasks. For the two settings of the tobacco leaf abnormality dataset, the accuracies were achieved at 45.5% and 56.5%. By using the multisymptom solution, the best accuracy can be lifted to 60.7% in 16-way, 1-shot tasks and achieved at 81.8% in 16-way, 10-shot tasks. The results show that our method improves the performance greatly by enhancing feature representation, especially for tasks that contain categories with high similarity. The desensitization of data when crossing domains also validates that the FREN has a strong generalization ability.
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- 2024
191. A compendium of genetic regulatory effects across pig tissues.
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Teng, Jinyan, Gao, Yahui, Yin, Hongwei, Bai, Zhonghao, Liu, Shuli, Zeng, Haonan, Bai, Lijing, Cai, Zexi, Zhao, Bingru, Li, Xiujin, Xu, Zhiting, Lin, Qing, Pan, Zhangyuan, Yang, Wenjing, Yu, Xiaoshan, Guan, Dailu, Hou, Yali, Keel, Brittney, Rohrer, Gary, Lindholm-Perry, Amanda, Oliver, William, Ballester, Maria, Crespo-Piazuelo, Daniel, Quintanilla, Raquel, Canela-Xandri, Oriol, Rawlik, Konrad, Xia, Charley, Yao, Yuelin, Zhao, Qianyi, Yao, Wenye, Yang, Liu, Li, Houcheng, Zhang, Huicong, Liao, Wang, Chen, Tianshuo, Karlskov-Mortensen, Peter, Fredholm, Merete, Amills, Marcel, Clop, Alex, Giuffra, Elisabetta, Wu, Jun, Cai, Xiaodian, Diao, Shuqi, Pan, Xiangchun, Wei, Chen, Li, Jinghui, Cheng, Hao, Wang, Sheng, Su, Guosheng, Sahana, Goutam, Lund, Mogens, Dekkers, Jack, Kramer, Luke, Tuggle, Christopher, Corbett, Ryan, Groenen, Martien, Madsen, Ole, Gòdia, Marta, Rocha, Dominique, Charles, Mathieu, Li, Cong-Jun, Pausch, Hubert, Hu, Xiaoxiang, Frantz, Laurent, Luo, Yonglun, Lin, Lin, Zhou, Zhongyin, Zhang, Zhe, Chen, Zitao, Cui, Leilei, Xiang, Ruidong, Shen, Xia, Li, Pinghua, Huang, Ruihua, Tang, Guoqing, Li, Mingzhou, Zhao, Yunxiang, Yi, Guoqiang, Tang, Zhonglin, Jiang, Jicai, Zhao, Fuping, Yuan, Xiaolong, Liu, Xiaohong, Chen, Yaosheng, Xu, Xuewen, Zhao, Shuhong, Zhao, Pengju, Haley, Chris, Zhou, Huaijun, Wang, Qishan, Pan, Yuchun, Ding, Xiangdong, Ma, Li, Li, Jiaqi, Navarro, Pau, Zhang, Qin, Li, Bingjie, Tenesa, Albert, Li, Kui, and Liu, George
- Subjects
Swine ,Animals ,Humans ,Gene Expression Regulation ,Genotype ,Phenotype ,Sequence Analysis ,RNA ,Gene Expression Profiling - Abstract
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.
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- 2024
192. Acute Mesenteric Ischemia, Reality in Catalonia (AMI_CAT)
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Hospital Clinic of Barcelona, Germans Trias i Pujol Hospital, Parc Taulí Hospital Universitari, Hospital de la Santa creu i Sant Pau - Barcelona, Hospital Vall d'Hebron, Hospital Universitari Joan XXIII de Tarragona., Hospital de Manresa, Hospital de Mataró, Hospital Universitari Sant Joan de Reus, Hospital de Sant Joan Despí Moisès Broggi, Hospital d'Igualada, Consorci Hospitalari de Vic, Hospital Arnau de Vilanova, Hospital de Mollet, Hospital de Terrassa, Hospital Universitari de Bellvitge, and Ana María González Castillo, Doctor
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- 2024
193. Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders (MES-CoBraD)
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Rabin Medical Center, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, King's College London, Uppsala University, Holistic IKE, National Technical University of Athens, Evolution Projects, Engineering Ingegneria Informatica S.p.A., SOFTWARE IMAGINATION & VISION SRL, Vrije Universiteit Brussel, STICHTING LIBER, University of Edinburgh, and CyberEthics Lab. srls
- Published
- 2024
194. Continence After Vaginal Prolapse Surgery
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Consorci Sanitari de Terrassa, Parc Taulí Hospital Universitari, Hospital de Viladecans, Hospital Universitari de Bellvitge, Hospital d'Igualada, Hospital de Mataró, Fundació Hospital de l'Esperit Sant, Germans Trias i Pujol Hospital, Hospital Santa Caterina, Hospital de Granollers, Hospital del Mar, Hospital Universitari Joan XXIII de Tarragona., and Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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- 2024
195. Study to Evaluate the Safety and Effect of HIVconsv Vaccines in Combination With Histone Deacetylase Inhibitor Romidepsin on the Viral Rebound Kinetic After Treatment Interruption in Early Treated HIV-1 Infected Individuals
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Germans Trias i Pujol Hospital, Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia, Hospital Clinic of Barcelona, Hospital de Sant Pau, HIVACAT, University of Oxford, and BCN Checkpoint
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- 2024
196. Transvaginal Human Acellular Dermal Matrix for Prolapse Treatment
- Author
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Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Germans Trias i Pujol Hospital, and Hospital Arnau de Vilanova
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- 2024
197. Validation of a Digital Platform for Functional Respiratory Rehabilitation (ReHub)
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Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau and Centre de Validació Clínica de Solucions Digitals
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- 2024
198. EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial)
- Author
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Hospital Mutua de Terrassa, Hospital Clínico Universitario de Valencia, Hospital General Universitario de Alicante, Hospital Universitario Ramon y Cajal, Hospital General Universitario de Castellón, Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Santiago, University Hospital Virgen de las Nieves, Complejo Hospitalario de Navarra, Hospital de Sant Pau, University of Salamanca, and Joan B Gornals, PhD and Head of Interventional Endoscopy Unit
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- 2024
199. EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial)
- Author
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Hospital Mutua de Terrassa, Hospital Clínico Universitario de Valencia, Hospital General Universitario de Alicante, Hospital Universitario Ramon y Cajal, Hospital General Universitario de Castellón, Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Santiago, University Hospital Virgen de las Nieves, Complejo Hospitalario de Navarra, Hospital de Sant Pau, University of Salamanca, and Joan B Gornals, PhD and Head of Interventional Endoscopy Unit
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- 2024
200. Endoscopic Ultrasound-Guided Gastroenterostomy Nationwide: Prospective Registry. (GESICA)
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Hospital Mutua de Terrassa, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Hospital del Mar, Germans Trias i Pujol Hospital, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Hospital de Granollers, Hospital General Universitario Gregorio Marañon, Hospital Universitario Virgen Macarena, Hospital Universitario La Paz, Hospital Universitario del Sureste, and Joan B Gornals, Principal Investigator, Director of Endoscopy Programme
- Published
- 2024
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