340 results on '"Patel, R. D."'
Search Results
152. Morphology of polyacrylonitrile
- Author
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Gohil, R. M., primary, Patel, K. C., additional, and Patel, R. D., additional
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- 1972
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153. Application of the FLORY‐FOX‐SCHAEFGEN intrinsic viscosity molecular weight relation to high polymers
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Patel, J. R., primary, Patel, C. K., additional, and Patel, R. D., additional
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- 1968
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154. Crystallization of amylose triacetate
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Thakker, R. A., primary, Patel, C. K., additional, and Patel, R. D., additional
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- 1972
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155. Single crystals of high polymers by film formation
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Patel, G. N., primary and Patel, R. D., additional
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- 1970
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156. Lipase Activity of Gamma-irradiated Castor Seeds Germinated in Dark
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Thanki, R. J., primary, Patel, K. C., additional, and Patel, R. D., additional
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- 1965
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157. Über die physikalisch-chemischen Eigenschaften des Samenfettes von Citrullus colocynthis
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Patel, K. C., primary, Patel, R. D., additional, and Rabari, L. F., additional
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- 1961
- Full Text
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158. Untersuchung des Samenfettes von Mimusops hexandra
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Patel, R. D., primary, Rabari, L. F., additional, and Patel, K. C., additional
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- 1961
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- View/download PDF
159. Hedrite growth in polyacrylonitrile
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Gohil, R. M., primary, Patel, K. C., additional, and Patel, R. D., additional
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- 1971
- Full Text
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160. Effect of Buoyancy on Forced Convection in a Two-dimensional Wall Jet along a Vertical Wall
- Author
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Yang, J. W., primary and Patel, R. D., additional
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- 1973
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161. Ascorbic acid and ascorbic acid oxidase of ?-irradiatedMomordica charantia
- Author
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Vyas, D. N., primary, Thanki, R. J., additional, Patel, K. C., additional, and Patel, R. D., additional
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- 1965
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162. Test of theories of flory, ptitsyn, and kurata for dilute polymer solutions
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Patel, R. S., primary and Patel, R. D., additional
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- 1965
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163. Crescentic Glomerulonephritis Associated with Pulmonary Tuberculosis.
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KANODIA, K. V., PATEL, R. D., VANIKAR, A. V., SUTHAR, K. S., and TRIVEDI, H. L.
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URINARY organs ,TUBERCULOSIS case studies - Abstract
Tuberculosis of kidney and urinary tract is caused by members of the Mycobacterium tuberculosis complex. Kidney is usually infected by haematogenous spread of bacilli from focus of infection in the lungs. Glomerular involvement in tuberculosis presenting as a rapidly progressive glomerulonephritis is a rare entity. We report a rare case of crescentic glomerulonephritis associated with pulmonary tuberculosis in a 26-year-old man. Patient was treated with corticosteroids, haemodialysis, intravenous immunoglobulin and four cycles of plasmapheresis. He did not respond to 4-drug anti-tuberculosis treatment for renal pathology and was switched over to maintenance haemodialysis. However, he responded to pulmonary TB. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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164. Rare Co-existence of Squamous Cell Carcinoma with Infiltration of Renal Vein and Xanthogranulomatous Pyelonephritis.
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KANODIA, K. V., VANIKAR, A. V., PATEL, R. D., NIGAM, L. K., and TRIVEDI, H. L.
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SQUAMOUS cell carcinoma ,URINARY tract infections - Abstract
Primary renal squamous cell carcinoma is a very rare malignancy of the upper urinary tract. Most patients have history of chronic urolithiasis, analgesics abuse, radiotherapy or infection. Co-existence of SCC with xanthogranulomatous pyelonephritis is exceedingly rare with only few reports in the literature. We report a case of a 60-year-old male presented with right flank pain and mild tenderness of abdomen. Computed tomography of the abdomen revealed gross hydronephrosis with parenchymal thinning and irregular thick enhancing wall of pelvicalyceal system with multiple calculi in right kidney. Right renal vein appeared distended, filled with hypo dense material. Right nephrectomy was performed and sent for pathological examination. Histological evaluation revealed keratinizing squamous cell carcinoma with infiltration of renal vein and xanthogranulomatous pyelonephritis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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165. Radiation-induced intracranial osteosarcoma: A case report.
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Patel, R. D., Gadgil, N. M., Khare, M., and Majethia, N.
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RADIATION carcinogenesis , *BRAIN tumors , *OSTEOSARCOMA , *RADIOTHERAPY , *FETAL nerve tissue , *DIAGNOSIS , *TUMORS ,BRAIN tumor diagnosis - Abstract
A letter to the editor is presented in response to the case of a 52-year-old man presented with intracranial osteosarcoma with a previous history of radiotherapy.
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- 2014
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166. Adenoid cystic carcinoma of breast and the importance of differentiation from collagenous spherulosis by FNAC.
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PANDYA, AMRISH N., SHAH, PINAL, PATEL, R. D., and PATEL, PRASHANT R.
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ADENOID cystic carcinoma ,BREAST cancer ,ASPIRATORS ,CYTOLOGY ,HISTOPATHOLOGY ,IMMUNOHISTOCHEMISTRY - Abstract
We are presenting a case of adenoid cystic carcinoma (ACC) of breast in a 66-year-old woman having lump in left breast, admitted to surgical ward of our institute. A diagnosis of ACC of breast was made and subsequently confirmed histopathologically and on immunohistochemistry. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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167. Authors' reply.
- Author
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Vanikar, A V, Kanodia, K V, Patel, R D, Suthar, K S, Patel, H V, Gumber, M R, and Trivedi, H L
- Published
- 2013
168. Studies on active carbon: I. Preparation of active carbon from Kodrahusks using ZnCl2 as an activator
- Author
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Patel, K. C., Avasare, M. D., Mankad, B. N., and Patel, R. D.
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- 1960
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169. Ascorbic acid and ascorbic acid oxidase of γ-irradiatedMomordica charantia
- Author
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Vyas, D. N., Thanki, R. J., Patel, K. C., and Patel, R. D.
- Published
- 1965
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170. Studies on germinating peanut seeds
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Rabari, L. F., Patel, R. D., and Chohan, J. G.
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- 1961
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171. Pharmacognostic Evaluation of Melilotus officinalis Linn.
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Sheikh, N. A., Desai, T. R., and Patel, R. D.
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MELILOTUS indicus , *PHARMACOGNOSY , *PLANT morphology , *FOLIAR diagnosis , *COLLECTION & preservation of plant specimens , *STEREOLOGY - Abstract
Background: Melilotus officinalis Linn. (Fabaceae) historically has been used for a variety of medicinal purposes. Despite the popular medicinal utilization, still no conclusive study has been reported so far regarding the pharmacognostical standardization. Aim: Thus, the present study was focused to scientifically establish a standard monograph of M. officinalis on the basis of pharmacognostical parameters. Material and methods: The detailed macroscopic and qualitative as well as quantitative microscopic characters of M. officinalis were analyzed. Results: The morphological characters of M. officinalis were established. The transverse section of leaf shows lamina with single layered epidermis, anomocytic stomata, mesophyll, midrib with single layered epidermis and vascular strands were present in lamina. Stem contains single layered epidermis, cortex with several layers, phloem, xylem and starch grains. Root shows the presence of cork, phloem, xylem and starch grains. The powder characteristics of M. officinalis revels the presence of Epidermis, stomata, cork, parenchyma, mesophyll, fibers, spiral and pitted xylem vessels. The quantitative microscopy of leaf of M. officinalis reveals Stomatal number Upper surface (28.75 ± 2.5), Lower surface (38.37 ± 2.5); Stomatal index Upper surface (13.10 ± 1.50) Lower surface (12.58 ± 1.10); Vein islet number (96.25 ± 4.79), Vein termination number (27.50 ± 2.87) and Palisade ratio 6.5 ± 0.58. Conclusion: The obtained qualitative and quantitative standards would serve as a useful guide for correct identification, purity, standardization and preparation of monograph of M. officinalis. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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172. Pharmacognostic Evaluation of Epilobium hirsutum Linn.
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Sheikh, N. A., Desai, T. R., and Patel, R. D.
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EPILOBIUM , *PHARMACOGNOSY , *TRADITIONAL medicine , *PLANT morphology , *COLLECTION & preservation of plant specimens - Abstract
Background: Epilobium hirsutum Linn. (Onagraceae) is used widely as traditional medicine for its various medicinal values. Despite the popular utilization of this plant, still no conclusive study has been reported so far regarding the pharmacognostical standardization. Aim: Thus, the present study was aimed to scientifically establish a standard monograph of E. hirsutum on the basis of pharmacognostical aspects. Material and methods: Macroscopic, qualitative and quantitative microscopic characters of E. hirsutum were analyzed. Results: The diagnostic characters of the E. hirsutum were evaluated based on the macroscopical and microscopical characters. Conclusion: The obtained qualitative and quantitative standards will provide referential information for correct identification, purity, standardization and preparation of monograph of E. hirsutum. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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173. ChemInform Abstract: Aromatic Nucleophilic Substitution Reactions of 2-Chloroquinoxaline with Anilines in Ethanol.
- Author
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PATEL, R. D.
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- 1992
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174. Toxicity of Selected Insecticides against Cotton Mealybug (Phenacoccus solenopsis Tinsley) in Laboratory Bioassays.
- Author
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Padaliya, P. J., Desai, H. R., Bhanderi, G. R., and Patel, R. D.
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NIPAECOCCUS viridis , *MEALYBUGS , *INSECTICIDES , *BIOLOGICAL assay , *FARMERS - Published
- 2022
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175. A report of two cases of the management of cervical cancer in pregnancy by cone biopsy and laparoscopic pelvic node dissection.
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Herod, J. J. O., Decruze, S. B., and Patel, R. D.
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CASE studies , *CERVICAL cancer patients , *CANCER in pregnancy , *LAPAROSCOPIC surgery , *PELVIC surgery , *CANCER treatment - Abstract
Please cite this paper as: Herod J, Decruze S, Patel R. A report of two cases of the management of cervical cancer in pregnancy by cone biopsy and laparoscopic pelvic node dissection. BJOG 2010;117:1558-1561. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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176. Collapsing Glomerulopathy- A Troublemaker for the Renal Allograft: Lessons Learnt.
- Author
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Kanodia, K. V., Vanikar, A. V., Nigam, L. K., Patel, R. D., Suthar, K. S., Patel, H. V., and Trivedi, H. L.
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IMMUNOSUPPRESSIVE agents , *BIOPSY , *CREATININE , *DRUG toxicity , *ENZYME inhibitors , *GLOMERULONEPHRITIS , *GRAFT rejection , *HEMATURIA , *HOMOGRAFTS , *HYPERTENSION , *KIDNEY transplantation , *ORGAN donors , *PROTEINURIA , *URINALYSIS , *POLYOMAVIRUS diseases , *DISEASE prevalence , *RETROSPECTIVE studies , *DISEASE complications , *FOCAL segmental glomerulosclerosis , *PROGNOSIS , *DIAGNOSIS - Abstract
Collapsing glomerulopathy (CG) is a well-recognized distinct morphological pattern of proliferative parenchymal injury leading to rapid graft failure. We conducted a single-center retrospective study to evaluate the prevalence, clinicopathological features, and prognosis of CG in renal transplant recepient. We analyzed 2518 renal allograft biopsies performed from 2007 to 2015 and correlated their clinicopathological features. The prevalence of CG was 0.83% (21 out of 2518) of allograft biopsies with a higher prevalence of 1.4% during the period from 2012 to 2015. Out of 21 patients, 18 (85.71%) patients had undergone live donor and 3 (14.28%) patients had undergone deceased donor renal transplant. Hypertension was observed in 3 (14.28%) patients. The mean duration of diagnosis for CG was 1.85 ± 1.91 years. Urinalysis revealed microhematuria in 5 (23.8%) patients. The mean 24 h urinary protein excretion was 4.77 ± 5.3 g and serum creatinine was 2.12 ± 1.5 mg/dl. The predominant native kidney diseases in recipients were chronic glomerulonephritis of unknown etiology in 12 (57.14%) patients and hypertensive nephropathy in 3 (14.28%) patients. CG was associated with rejection in 9 (42.85%), calcineurin-inhibitor toxicity in 2 (9.5%), and BK virus nephropathy in 1 patient. All patients received standard triple immunosuppression. Eleven (52.38%) patients developed graft failure over a mean period of 2.2 ± 1.7 years and 6 (28.57%) patients recovered with stable graft function. CG can coexist with viral infection, drug toxicity, rejection, microvascular injury, etc. CG usually presents with moderate to severe proteinuria and may lead to rapid graft dysfunction and subsequent graft failure in most of the patients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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177. The effect of spherical nanoparticles on rheological properties of bi-dispersed magnetorheological fluids
- Author
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Upadhyay, R. [P D Patel Institute of Applied Science and K C Patel R & D Center, Charotar University of Science & Technology, CHARUSAT Campus, Changa, Gujarat (India)]
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- 2015
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178. Tongue flap: a challenge to the anesthesiologist.
- Author
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Jithesh, A. K., Patil, Y., Patel, R. D., and Dewoolkar, L. V.
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LETTERS to the editor , *PAIN management - Abstract
A letter to the editor is presented about the anesthetic management of a patient with palatal fistula or cleft palate.
- Published
- 2008
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179. Histological and Clinicopathological Evaluation of Liver Allograft Biopsy: An Initial Experience of Fifty Six Biopsies.
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KANODIA, K. V., VANIKAR, A. V., MODI, P. R., PATEL, R. D., SUTHAR, K. S., NIGAM, L. K., and TRIVEDI, H. L.
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CIRRHOSIS of the liver , *LIVER transplantation , *LIVER biopsy - Abstract
Introduction: Liver biopsy is gold standard for diagnosis of allograft dysfunction. Aim: The aim of study was to evaluate liver allograft biopsies performed for graft dysfunction, study the pattern of injury and intensity, and timeline of occurrence of graft dysfunction. Materials and Methods: Retrospective study was carried out of 56 liver allograft biopsies and their histological findings with clinical presentation were correlated. Totally 56 needle liver allograft biopsies from January 1210 to July 2014, obtained from 35 patients were studied for histological and clinicopathological evaluation. Results: The mean age was 53.2±5.48 years. The most common original disease was alcoholic cirrhosis. The most common histological lesion was acute cellular rejection (ACR) in 31 (55.36%) biopsies followed by preservation-reperfusion injury (PRI) in 10 (17.86%) biopsies and drug toxicity in 8 (14.29%) biopsies. Chronic rejection was reported in 2 (3.57%) and recurrence of HCV in 3 (5.36%). Ischemic coagulative necrosis and acute cholangitis were seen in 1 (1.79 %) case each. Conclusion: Alcoholic cirrhosis was the most common etiology for end stage liver disease. ACR and PRI were the major complications in liver allograft biopsies at our centre. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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180. Immunoglobulin M nephropathy nephropathy in adults and adolescents in India: A single-center study of natural history.
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Singhai, A. M., Vanikar, A. V ., Goplani, K. R., Kanodia, K. V ., Patel, R. D., Suthar, K. S., Patel, H. V., Gumber, M. R., Shah, P. R., and Trivedi, H. L.
- Published
- 2011
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181. Screening, Isolation and Characterization of Aerobic Magnetotactic Bacteria From Western Ghats Forest Soil.
- Author
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Mistry K, Markande AR, Patel JK, and Parekh K
- Abstract
Magnetotactic bacteria (MTB) are a unique ecophysiological group of iron-metabolizing bacteria that have immense potential biotechnological applications. These bacteria have predominantly been isolated from oxygen-limited conditions of aquatic niches and rarely from the soils. The Western Ghats biodiversity hotspot has been well-studied for its fauna and flora diversity. The present study includes optimization of enrichment medium for cultivation of MTB, to suit aerobic mesophiles from forest soil. The major components included were Ferric quinate and Resazurin. The enrichment and isolates were characterized for their magnetic properties using magnetotaxis on agar plates, Vibrating Sampler Magnetometer (VSM), and X-ray diffraction (XRD) analysis. The isolates, namely Bacillus sp. S1 (MN212953), Sphingoaurantiacus sp. S2_03 (MN212954), Burkholderia sp. S2_08 (MN212955) and Microvirga sp. S2_09 (MN212956) were isolated and characterized to have a magnetosome size of 2.5-8 nm. Our study is the first report on the enrichment and isolation of MTB from Western Ghats forest soil., Supplementary Information: The online version contains supplementary material available at 10.1007/s12088-024-01316-4., Competing Interests: Conflict of interestThis work has not been published elsewhere, either completely, in part, or in another form. The manuscript does not contain animal or human studies and is an original work of the authors. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors declare that they have no conflict of interest to declare., (© Association of Microbiologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
- Published
- 2024
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182. A structural and functional model for alkene dioxygenases.
- Author
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Banerjee A, Creek AE, Malkhasian AYS, Joseph AM, Lowes KC, Brennessel WW, Omlor A, Schünemann V, Singh P, Jackson TA, and Chavez FA
- Abstract
In this article, we report sterically-controlled iron sites based on non-chelating bulky imidazole ligands. Adding 6 equiv. of 1,2-dimethylimidazole (1,2-Me
2 Im) to Fe(OTf)2 ⋅2CH3 CN affords the first example of a 5-coordinate imidazole‑iron complex ([Fe(1,2-Me2 Im)5 ](OTf)2 , 1). The structure is distorted square pyramidal (τ5 = 0.41). When ani Pr group is substituted for the methyl group at the 2-position on the imidazole (2-i Pr-1-MeIm), the 14-electron complex ([Fe(2-i Pr-1-MeIm)4 ](OTf)2 , 2) is obtained. This complex exhibits slightly distorted tetrahedral geometry (τ'4 = 0.93) with four N-donors and serves as a 4-His iron structural model complex for carotenoid cleavage dioxygenases (CCD). The electronic structure of 1 and 2 were characterized by Mössbauer spectroscopy. Reactions of 1 and 2 with model olefin substrates (1-R-4-(1-methoxyprop-1-en-2-yl)benzene; R = Me or Br) in the presence of oxygen result in olefin cleavage yielding ketone and aldehyde products, although 2 yields more products than 1. Support for a proposed reaction mechanism for 2 is offered from Density Functional Theory (DFT) calculations., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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183. Bacterial cellulose microfilament biochar-architectured chitosan/polyethyleneimine beads for enhanced tetracycline and metronidazole adsorption.
- Author
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Mosaffa E, Ramsheh NA, Banerjee A, and Ghafuri H
- Subjects
- Adsorption, Kinetics, Hydrogen-Ion Concentration, Water Purification methods, Anti-Bacterial Agents chemistry, Tetracycline chemistry, Tetracycline isolation & purification, Chitosan chemistry, Charcoal chemistry, Cellulose chemistry, Metronidazole chemistry, Water Pollutants, Chemical chemistry, Water Pollutants, Chemical isolation & purification, Polyethyleneimine chemistry
- Abstract
This study investigates the potential applications of incorporating 2D bacterial cellulose microfibers (BCM) biochar into chitosan/polyethyleneimine beads as a semi-natural sorbent for the efficient removal of tetracycline (TET) and metronidazole (MET) antibiotics. Batch adsorption experiments and characterization techniques evaluate removal performance and synthesized adsorbent properties. The adsorbent eliminated 99.13 % and 90 % of TET and MET at a 10 mg.L
-1 concentration with optimal pH values of 8 and 6, respectively, for 90 min. Under optimum conditions and a 400 mg.L-1 concentration, MET and TET have possessed the maximum adsorption capacities of 691.325 and 960.778 mg.g-1 , respectively. According to the isothermal analysis, the adsorption of TET fundamentally follows the Temkin (R2 = 0.997), Redlich-Peterson (R2 = 0.996), and Langmuir (R2 = 0.996) models. In contrast, the MET adsorption can be described by the Langmuir (R2 = 0.997), and Toth (R2 = 0.991) models. The pseudo-second-order (R2 = 0.998, 0.992) and Avrami (R2 = 0.999, 0.999) kinetic models were well-fitted with the kinetic results for MET and TET respectively. Diffusion models recommend that pore, liquid-film, and intraparticle diffusion govern the rate of the adsorption process. The developed semi-natural sorbent demonstrated exceptional adsorption capacity over eleven cycles due to its porous bead structure, making it a potential candidate for wastewater remediation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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- View/download PDF
184. Synthesis, microstructural and optical characterizations of sol-gel grown gadolinium doped cerium oxide ceramics.
- Author
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Dhruv SD, Kolte J, Solanki P, Deshpande MP, Solanki V, Tailor J, Agrawal N, Patel VA, Markna JH, Kataria B, and Dhruv DK
- Abstract
In this study, through the utilization of the sol-gel combustion tactic, gadolinium (Gd)-doped cerium oxide (CeO
2 ), Ce1- x Gdx O2 ( x = 0.00, 0.10, 0.20 and 0.30 (GDC)) ceramics were attained. The synthesized GDC ceramics were investigated using X-ray diffraction (XRD) to scrutinize their crystal structures and phase clarities. The obtained GDC ceramics have a single-phase cubic structure and belong to the crystallographic space group fm 3̄ m (225). The measurement of the diffraction angle of each reflection and the subsequent smearing of the renowned Bragg's relation provided coarse d -interplanar spacings. The stacking fault (SF) values of pure and Gd-doped CeO2 ceramics were assessed. To muse the degree of preferred orientation ( σ ) of crystallites along a crystal plane ( h k l ), the texture coefficient ( Ci ) of each XRD peak of GDC ceramics is gauged. By determining the interplanar distance ( dh k l ), the Bravais theory sheds light on the material's development. By exploiting Miller indices for the prime (1 1 1) plane, the lattice constants of GDC ceramics and cell volumes were obtained. Multiple techniques were employed to ascertain the microstructural parameters of GDC ceramics. A pyrometer substantiated the density of GDC ceramics. The room temperature (RT) Fourier transform infrared (FTIR) spectra of both un-doped and Gd-doped CeO2 were obtained. The UV-vis-NIR spectrometer recorded the GDC ceramics' reflectance ( R ) spectra at RT. For both undoped and Gd-doped CeO2 , the absorption coefficient ( α ) spectra showed two distinct peaks. The R -dependent refractive index ( η ) and the α -dependent extinction coefficient ( k ) were determined for all GDC samples. The optical band gap ( Eg ) was obtained by integrating the Tauc and Kubelka-Munk approaches for GDC ceramics. For each GDC sample, the imaginary ( εi ) and real ( εr ) dielectric constants, as well as the dissipation factor (tan δ ), were determined local to the characteristic wavelength ( λc ). Calculations were made for the Urbach energy ( EU ) and Urbach absorption coefficient ( α0 ) for GDC ceramics. The minimum and maximum values of optical ( σo ) and electrical ( σe ) conductivity for GDC ceramics were determined. The volume (VELF) and surface (SELF) energy loss functions, which depend on the constants εi and εr , were used to measure electrons' energy loss rates as they travel across the surface. Raman spectroscopy revealed various vibrational modes in GDC ceramics. Finally, the implications are discussed herein., Competing Interests: “The authors have no related financial or non-financial interests to disclose.”, (This journal is © The Royal Society of Chemistry.)- Published
- 2024
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185. Comprehensive analysis of cationic dye removal from synthetic and industrial wastewater using a semi-natural curcumin grafted biochar/poly acrylic acid composite hydrogel.
- Author
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Mosaffa E, Patel RI, Banerjee A, Basak BB, and Oroujzadeh M
- Abstract
Polymer composites offer a tailored framework as an exceptional candidate for water treatment due to their tunable chemical structure, porous 3D architecture, physiochemical stability, accessibility, pH-sensitivity and ease of use. In this study, curcumin-engineered biochar is embedded into a cross-linked polyacrylic acid hydrogel matrix using in situ polymerization for developing a semi-natural adsorbent for the removal of cationic dye from an aqueous solution. The physicochemical features of the generated composite hydrogel are significantly influenced by the implementation of curcumin-grafted biochar into the polyacrylic acid substrate. Comprehensive characteristic approaches were employed to explore all aspects of the adsorbent's properties, especially its removal efficacy. The methodical adsorption study was accomplished by monitoring dynamic factors such as pH, adsorbent content, time frame, and initial dye concentration. The presence of the porous aromatized structure of biochar, active oxygen-enrich functional groups (carboxyl, hydroxyl, keto, enol, ether) coupled with the conjugated curcumin structure facilitate the effective establishment of hydrogen bonds, electrostatic interactions, π-π interactions, electron donor-acceptor and charge-assisted H-bonding with the malachite green (MG) and rhodamine B (Rho) molecules. The highest adsorption capacities of MG and Rho reached 521 mg g
-1 and 741 mg g-1 respectively, in the range of neutral pH, considering their molecular nature, functionalities, and unique adsorption mechanisms. The isothermal modeling was carried out with Henry, Langmuir, Jovanovic, Freundlich, Temkin, and Koble-Corrigan models to determine the adsorption system. Additionally, the kinetic data were assessed with Bangham, pseudo-first-order, pseudo-second-order, intra-particle, and liquid film diffusion models to ascertain the rate-limiting phase. The Koble-Corrigan and Langmuir isotherm models ( R2 > 0.997) as well as pseudo-second-order ( R2 > 0.998) and Elovich ( R2 = 0.983 and 0.995) kinetics models provide a substantial level of concordance with empirical findings. The analysis of non-linear diffusion models revealed that the Bangham ( R2 > 0.995) pore and liquid film diffusion ( R2 > 0.960) models has major influence on the rate of the adsorption procedure. The binary adsorption test demonstrated higher efficacy of the synthesized adsorbent in the removal of malachite as compared to rhodamine. This study sheds light on the design of a cost-effective semi-natural polymeric composite for treating dye-polluted wastewaters, a major milestone toward environmental and ecological sustainability., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)- Published
- 2024
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- View/download PDF
186. Bacterial cellulose microfiber reinforced hollow chitosan beads decorated with cross-linked melamine plates for the removal of the Congo red.
- Author
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Mosaffa E, Patel D, Ramsheh NA, Patel RI, Banerjee A, and Ghafuri H
- Subjects
- Congo Red chemistry, Cellulose chemistry, Adsorption, Kinetics, Imines, Hydrogen-Ion Concentration, Chitosan chemistry, Water Pollutants, Chemical chemistry
- Abstract
In this epoch, the disposal of multipollutant wastewater inevitably compromises life on Earth. In this study, the inclusion of Bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates creates a unique 3D bead structure for anionic dye removal. The establishment of an imine network between melamine and chitosan, along with the quantity of inter- and intra‑hydrogen bonds, boosts the specific surface area to 106.68 m
2 .g-1 . Removal efficiency and in-depth comprehension of synthesized adsorbent characteristics were assessed using batch adsorption experiments and characterization methods. Additionally, pH, adsorbent quantity, time, beginning concentration of solution, and temperature were analyzed and optimized as adsorption essential factors. Owing to the profusion of hydroxyl, amine, imine functional groups and aromatic rings, the synthesized adsorbent intimated an astonishing maximum adsorption capacity of 3168 mg.g-1 in Congo red dye removal at pH 5.5. Based on the kinetic evaluation, pseudo-second-order (R2 = 0.999), pseudo-first-order (R2 = 0.964), and Avrami (R2 = 0.986) models were well-fitted with the kinetic results among the seven investigated models. The isothermal study reveals that the adsorption mechanism predominantly follows the Redlich-Peterson (R2 = 0.996), Koble-Carrigan, and Hill isotherm models (R2 = 0.994). The developed semi-natural sorbent suggests high adsorption capacity, which results from its exceptional structure, presenting promising implications for wastewater treatment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2024
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187. Enhanced therapeutic action of Trastuzumab loaded Zn x Mn 1-x Fe 2 O 4 nanoparticles using a pre-treatment step for hyperthermia treatment of HER2+ breast cancer.
- Author
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Singh S, Akhil Varri VS, Parekh K, and Misra SK
- Subjects
- Humans, Female, Trastuzumab pharmacology, Trastuzumab chemistry, Receptor, ErbB-2 metabolism, Zinc, Cell Line, Tumor, Breast Neoplasms drug therapy, Breast Neoplasms metabolism, Hyperthermia, Induced, Nanoparticles
- Abstract
In this study, Ferrites (Fe
3 O4 , MnFe2 O4 , ZnFe2 O4 ) and different stoichiometric ratios of Znx Mn1-x Fe2 O4 (x = 0.2, 0.4, 0.6, and 0.8) nanoparticles (<15 nm) were synthesized by microwave-assisted method and optimised for hyperthermia studies. The selection of the optimised variant of ferrite i.e. Zn0.4 Mn0.6 Fe2 O4 was found to be the best variant based on VSM (38.14 emu g-1 ) hyperthermia-based temperature rise (maximum ΔT of 38 °C), SAR and ILP values. Trastuzumab, which is known to bind with HER2 receptors of breast cancer was chemically tethered onto Zn0.4 Mn0.6 Fe2 O4 nanoparticles through EDC/NHS coupling with a loading efficiency of 80%. The attached Trastuzumab aided during the pre-treatment step by aiding in the internalisation of Zn0.4 Mn0.6 Fe2 O4 nanoparticles, with cellular uptake of 11% in SK-BR-3 (cancerous HER2+) cells compared to ∼5% for MDA-MB-231 (cancerous HER2-) and RPE-1 (non-cancerous) cells. In the presence of a hyperthermia trigger for 15 mins, Znx Mn1-x Fe2 O4 -Trastuzumab formulation had a maximum therapeutic effect by reducing the SK-BR-3 cell viability to 14% without adversely affecting the RPE-1 cells. The mechanism of Znx Mn1-x Fe2 O4 -Trastuzumab combination was examined using an internalisation study, MTT-based viability, proliferation study, and ROS generation assay. By utilizing both Trastuzumab and hyperthermia, we achieve their synergistic anticancer properties while minimizing the drug requirement and reducing any effect on non-cancerous cells., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2023
- Full Text
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188. Unveiling the Genetic Symphony: Harnessing CRISPR-Cas Genome Editing for Effective Insect Pest Management.
- Author
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Komal J, Desai HR, Samal I, Mastinu A, Patel RD, Kumar PVD, Majhi PK, Mahanta DK, and Bhoi TK
- Abstract
Phytophagous insects pose a significant threat to global crop yield and food security. The need for increased agricultural output while reducing dependence on harmful synthetic insecticides necessitates the implementation of innovative methods. The utilization of CRISPR-Cas (Clustered regularly interspaced short palindromic repeats) technology to develop insect pest-resistant plants is believed to be a highly effective approach in reducing production expenses and enhancing the profitability of farms. Insect genome research provides vital insights into gene functions, allowing for a better knowledge of insect biology, adaptability, and the development of targeted pest management and disease prevention measures. The CRISPR-Cas gene editing technique has the capability to modify the DNA of insects, either to trigger a gene drive or to overcome their resistance to specific insecticides. The advancements in CRISPR technology and its various applications have shown potential in developing insect-resistant varieties of plants and other strategies for effective pest management through a sustainable approach. This could have significant consequences for ensuring food security. This approach involves using genome editing to create modified insects or crop plants. The article critically analyzed and discussed the potential and challenges associated with exploring and utilizing CRISPR-Cas technology for reducing insect pest pressure in crop plants., Competing Interests: The authors declared no conflict of interest.
- Published
- 2023
- Full Text
- View/download PDF
189. Dielectric spectrum of a ferrofluid layer exposed to a gradient magnetic field.
- Author
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Rajňák M, Dolník B, Paulovičová K, Cimbala R, Kopčanský P, Timko M, Parekh K, and Upadhyay RV
- Abstract
A low-frequency dielectric response of a ferrofluid based on transformer oil and MnZn ferrite nanoparticles is investigated in a gradient magnetic field. Four ferrofluid samples of various nanoparticle concentrations were introduced into planar micro-capacitors located over a magnetized tip. The dielectric spectra were measured in the frequency range from 0.1 Hz to 200 kHz and in the local magnetic field up to 100 mT. The spectra exhibit a dielectric relaxation ascribed to nanoparticle interfacial polarization. The low-frequency spectrum of each ferrofluid decreases upon application of the magnetic field up to 20 mT. The decrease in dielectric permittivity is caused by a magnetic force acting on larger nanoparticles in the gradient magnetic field. It is assumed that the interfaces of the concentrated nanoparticles in the gradient field do not contribute to the effective dielectric response. This reduces the effective relaxation time and shifts the relaxation toward higher frequencies. The dielectric spectra are well described by a relaxation fit function consisting of one Havriliak-Negami and a conductivity term. The fitting confirms that the only effect of the gradient magnetic field on the dielectric spectra is the shift of the dielectric relaxation and the decrease of the amplitude in the imaginary permittivity. This behavior is evident from a master plot, where all dielectric relaxations are superimposed on a single line. The knowledge of the presented behavior of the ferrofluid may be valuable when applying a ferrofluid to sharply magnetized parts of various electrical equipment (wires, tips, screws, nails, edges) as a liquid dielectric medium., (© 2023 Author(s). Published under an exclusive license by AIP Publishing.)
- Published
- 2023
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190. Optimization of magnetic fluid hyperthermia protocols for the elimination of breast cancer cells MCF7 using Mn-Zn ferrite ferrofluid.
- Author
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Bhardwaj A, Parekh K, and Jain N
- Subjects
- Humans, Female, MCF-7 Cells, Magnetic Fields, Zinc, Hyperthermia, Induced methods, Breast Neoplasms therapy
- Abstract
The present study aimed to optimize magnetic fluid hyperthermia (MFH) protocols by standardizing MF incubation time, hyperthermic duration, magnetic field, and MFH sessions to achieve a better hyperthermic response for the profuse killing of human breast cancer cell cells MCF7. Magnetic nanoparticles and MF were characterized using XRD, VSM, and DLS. Induction heating was performed for 30 min at field strengths of 12.5 and 13.3 kA/m at a fixed frequency of 330 kHz with varying concentrations and incubation duration on MCF7 cells. Single and multiple sessions hyperthermia protocols were used to kill MCF7 cells and the cytotoxicity effect was analyzed using MTT assay. Single and multiple sessions MFH protocols were established to kill breast cancer cells utilizing 0.2 mg/mL MF at 13.3 kA/m field and 330 kHz frequency and maintaining the hyperthermic temperature of 43-45 °C for 30 min. The single session MFH revealed severe toxicity of MF leading to more than 75% of cell death after 24 h of MF incubation. Multiple sessions hyperthermia resulted in more than 90% killing of MCF7 cells after two consequent 3 h MF incubation with 3 h gap. Each 3 h of MF incubation was followed by 30 min of induction heating. Multiple sessions hyperthermia was effective in killing a larger cell population compared to the single session protocol. The results may help in optimizing protocols for the profuse killing of cancer cells of multiple origins, and aid in deciding futuristic in vivo MFH-based therapeutic strategies against breast cancer. Variation in MCF7 cells' viability due to HT, MF, and MF + HT in multiple sessions., (© 2023. The Author(s).)
- Published
- 2023
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191. Prevalence of cardiovascular disease and osteoarthritis in obese population of Hail region, Saudi Arabia.
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Alanazi J, Unnisa A, Patel RD, Itumalla R, Alanazi M, Alharby TN, Jandrajupalli SB, Hussain T, Elamine BA, and Mohamed OA
- Subjects
- Humans, Male, Female, Prevalence, Saudi Arabia epidemiology, Cross-Sectional Studies, Obesity epidemiology, Cholesterol, Cardiovascular Diseases epidemiology, Osteoarthritis epidemiology, Hypertension, Osteoarthritis, Knee
- Abstract
Objective: The aim of the study was to analyze if there was a link between chronic diseases, like cardiovascular disease (CVD) and osteoarthritis (OA), and obesity in the population of Saudi Arabia's Hail region., Materials and Methods: The study was conducted over 12 months using an observational cross-sectional survey on 172 patients from five clinics in Hail, Saudi Arabia. A total of 172 individuals with obesity (BMI ≥ 30) finally participated in this research. The study evaluated sociodemographic variables via an electronic questionnaire with voluntary participation., Results: The study found a 76% prevalence of joint pain and 77.9% prevalence of cardiovascular abnormalities. Patients with CVD were older (58±23 vs. 56±12 years) than those with OA. CVD cases were found in 42 (31.3%) males and 92 (68.7%) females, whereas OA cases were recognized in 24 (18.5%) males and 106 (81.5%) females. The occurrence of various CVDs among our participants was 43 (32%) for high cholesterol, 64 (48%) for hypertension, and 27 for both high cholesterol and hypertension (20%). Definite osteophytes were found in 28 of 24 male knees (14 right and 14 left knees) and 175 of 106 female knees (88 right knees and 87 left knees)., Conclusions: The prevalence of obesity in the Hail region has continued to be a risk factor for CVD and OA in 2019 and 2020. The Saudi population has shown a higher prevalence of radiographic evidence of OA of the knee and associated symptoms than western civilizations, and preventive interventions are desperately needed in order to minimize overweight and obesity.
- Published
- 2022
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192. Comparative analysis between mono approach and multi approaches in managing T2DM: a survey-based study.
- Author
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Alanazi M, Unnisa A, Patel RD, Alanazi J, Khalid M, Ahmad S, Jandrajupalli SB, Hussain T, Abobaker SH, and Chandolu S
- Subjects
- Blood Glucose analysis, Cross-Sectional Studies, Female, Glycated Hemoglobin analysis, Humans, Male, Surveys and Questionnaires, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 therapy
- Abstract
Objective: The aim of the study was to analytically compare the therapeutic effect of the addition of diet modification and regular exercise to oral agents., Materials and Methods: This cross-sectional study surveyed 1248 participants via online and offline modes by employing a questionnaire about an individual's management of diabetes. Group 1 patients follow Single Approach Management for Type 2 Diabetes Mellitus (T2DM), while Group 2 and Group 3 patients follow Multi-Approach Management for T2DM. Based on the answers, the participants were classified into three groups. The diagnostic criteria of Diabetes Mellitus Type-2 in this study were done by determining morning Fasting Blood Sugar (FBS) and glycated Hemoglobin (HbA1c)., Results: The current study found 656 single oral agent users and 592 combination regimens users among all the study participants. The study also found that, among all participants, 511 patients were on mild to moderate diet modification while 325 patients were on moderate to severe diet modification. The study also noted that 232 males and 215 females took Complementary and Alternative Medicines (CAM). Of 447 patients, 12 showed menstrual abnormalities (2.6%), and 18 had mild diarrhoea (4%). The study also found that there is a vital significance of lowering FBS and HbA1c with the management strategies (p=0.000). The study showed a strong association between group 3 and improved FBS and HbA1c (p=0.000)., Conclusions: This study reveals that diet modification and regular exercise improve FBS and HbA1c levels significantly. Hence, diet modification and exercise can be added as adjuvants and should be incorporated into the management guidelines of T2DM.
- Published
- 2022
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193. Management of video-assisted thoracoscopic (VATs) bilateral cardiac sympathectomy in refractory ventricular storm: A case report.
- Author
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Sakrikar GR, Buddhi M, Patel RD, and Mathkar SS
- Subjects
- Aged, Heart, Humans, Male, Sympathectomy, Treatment Outcome, Tachycardia, Ventricular, Thoracic Surgery, Video-Assisted
- Abstract
A 65-year-old male post-CABG surgery presented with history of ventricular storm refractory to antiarrhythmics and requiring multiple DC shocks. He got posted for VATs bilateral cardiac denervation for sympathetic remodulation. Patient was induced with high dose opioids and Etomidate and intubated with 37Fr left double lumen tube. A multidisciplinary approach was planned to tackle peri-operative cardiac event along with the placement of invasive monitors. Events that might lead to sympathetic overactivation because of laryngoscopy, pain, capnothorax, and surgical handling were kept in mind and avoided with optimum depth of anesthesia, analgesia, and pharmacological sympatholysis. There was no major cardiac event intraoperatively as well as in postoperative period., Competing Interests: None
- Published
- 2022
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194. Probing the Mechanism for 2,4'-Dihydroxyacetophenone Dioxygenase Using Biomimetic Iron Complexes.
- Author
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Banerjee A, Li J, Molenda MA, Opalade AA, Adhikary A, Brennessel WW, Malkhasian AYS, Jackson TA, and Chavez FA
- Subjects
- Alcaligenes enzymology, Biomimetic Materials chemistry, Density Functional Theory, Dioxygenases chemistry, Iron Compounds chemical synthesis, Iron Compounds chemistry, Models, Molecular, Molecular Structure, Biomimetic Materials metabolism, Dioxygenases metabolism, Iron Compounds metabolism
- Abstract
In this study, we report the synthesis and characterization of [Fe(T1Et4iPrIP)(2-OH-AP)(OTf)](OTf) ( 2 ), [Fe(T1Et4iPrIP)(2-O-AP)](OTf) ( 3 ), and [Fe(T1Et4iPrIP)(DMF)
3 ](OTf)3 ( 4 ) (T1Et4iPrIP = tris(1-ethyl-4-isopropyl-imidazolyl)phosphine; 2-OH-AP = 2-hydroxyacetophenone, and 2-O-AP- = monodeprotonated 2-hydroxyacetophenone). Both 2 and 3 serve as model complexes for the enzyme-substrate adduct for the nonheme enzyme 2,4'-dihydroacetophenone (DHAP) dioxygenase or DAD, while 4 serves as a model for the ferric form of DAD. Complexes 2 - 4 have been characterized by X-ray crystallography which reveals T1Et4iPrIP to bind iron in a tridentate fashion. Complex 2 additionally contains a bidentate 2-OH-AP ligand and a monodentate triflate ligand yielding distorted octahedral geometry, while 3 possesses a bidentate 2-O-AP- ligand and exhibits distorted trigonal bipyramidal geometry (τ = 0.56). Complex 4 displays distorted octahedral geometry with 3 DMF ligands completing the ligand set. The UV-vis spectrum of 2 matches more closely to the DAD-substrate spectrum than 3 , and therefore, it is believed that the substrate for DAD is bound in the protonated form. TD-DFT studies indicate that visible absorption bands for 2 and 3 are due to MLCT bands. Complexes 2 and 3 are capable of oxidizing the coordinated substrate mimics in a stoichiometric and catalytic fashion in the presence of O2 . Complex 4 does not convert 2-OH-AP to products under the same catalytic conditions; however, it becomes anaerobically reduced in the presence of 2 equiv 2-OH-AP to 2 .- Published
- 2021
- Full Text
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195. In vitro hyperthermic effect of magnetic fluid on cervical and breast cancer cells.
- Author
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Bhardwaj A, Parekh K, and Jain N
- Subjects
- Breast Neoplasms pathology, Cell Death, Cell Survival, Culture Media, Female, Ferric Compounds administration & dosage, Ferric Compounds chemistry, HeLa Cells, Hot Temperature therapeutic use, Humans, In Vitro Techniques, MCF-7 Cells, Magnetic Fields, Magnetic Iron Oxide Nanoparticles chemistry, Manganese Compounds administration & dosage, Manganese Compounds chemistry, Phantoms, Imaging, Sepharose, Uterine Cervical Neoplasms pathology, Zinc Compounds administration & dosage, Zinc Compounds chemistry, Breast Neoplasms therapy, Hyperthermia, Induced methods, Magnetic Iron Oxide Nanoparticles administration & dosage, Uterine Cervical Neoplasms therapy
- Abstract
Self-regulating temperature-controlled nanoparticles such as Mn-Zn ferrite nanoparticles based magnetic fluid can be a better choice for magnetic fluid hyperthermia because of its controlled regulation of hyperthermia temperature window of 43-45 °C. To test this hypothesis magnetic fluid with said properties was synthesized, and its effect on cervical and breast cancer cell death was studied. We found that the hyperthermia window of 43-45 °C was maintained for one hour at the smallest possible concentration of 0.35 mg/mL without altering the magnetic field applicator parameters. Their hyperthermic effect on HeLa and MCF7 was investigated at the magnetic field of 15.3 kA/m and frequency 330 kHz, which is close to the upper safety limit of 5 * 10
9 A/m s. We have tested the cytotoxicity of synthesized Mn-Zn ferrite fluid using MTT assay and the results were validated by trypan blue dye exclusion assay that provides the naked eye microscopic view of actual cell death. Since cancer cells tend to resist treatment and show re-growth, we also looked into the effect of multiple sessions hyperthermia using a 24 h window till 72 h using trypan blue assay. The multiple sessions of hyperthermia showed promising results, and it indicated that a minimum of 3 sessions, each of one-hour duration, is required for the complete killing of cancer cells. Moreover, to simulate an in vivo cellular environment, a phantom consisting of magnetic nanoparticles dispersed in 1 and 5% agarose gel was constituted and studied. These results will help to decide the magnetic fluid based hyperthermic therapeutic strategies using temperature-sensitive magnetic fluid.- Published
- 2020
- Full Text
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196. The transfer of unsterilized material from Mars to Phobos: Laboratory tests, modelling and statistical evaluation.
- Author
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Patel MR, Pearson VK, Evans DJ, Summers DJ, Paton S, Truscott P, Pottage T, Bennett A, Gow JPD, Goodyear MD, Mason JP, Leese MR, and Patel RD
- Subjects
- Models, Theoretical, Solar System, Exobiology, Extraterrestrial Environment, Mars, Space Flight, Spacecraft, Sterilization
- Abstract
Sample return missions to Phobos are the subject of future exploration plans. Given the proximity of Phobos to Mars, Mars' potential to have supported life, and the possibility of material transfer from Mars to Phobos, careful consideration of planetary protection is required. If life exists, or ever existed, on Mars, there is a possibility that material carrying organisms could be present on Phobos and be collected by a sample return mission such as the Japanese Martian Moons eXplorer (MMX). Here we describe laboratory experiments, theoretical modelling and statistical analysis undertaken to quantify whether the likelihood of a sample from Phobos material containing unsterilized material transferred from Mars is less than 10
-6 , the threshold to transition between restricted and unrestricted sample return classification for planetary protection. We have created heat, impact and radiation sterilization models based on the Phobos environment, and through statistical analyses investigated the level of sterilization expected for martian material transferred to Phobos. These analyses indicate that radiation is the major sterilization factor, sterilizing the Phobos surface over timescales of millions of years. The specific events of most relevance in the Phobos sample return context are the 'young' cratering events on Mars that result in Zunil-sized craters, which can emplace a large mass of martian material on Phobos, in a short period of time, thus inhibiting the effects of radiation sterilization. Major unknowns that cannot yet be constrained accurately enough are found to drive the results - the most critical being the determination of exact crater ages to statistical certainty, and the initial biological loading on Mars prior to transfer. We find that, when taking a conservative perspective and assuming the best-case scenario for organism survival, for a 100 g sample of the Phobos regolith to be below the planetary protection requirement for unrestricted sample return, the initial biological loading on Mars must be <8.2 × 103 cfu kg-1 . For the planned MMX mission, a ∼10 g sample to be obtained from a 25-30 mm diameter core as planned would require an initial martian biological loading to be <1.6 × 104 cfu kg-1 , in order to remain compliant with the planetary protection threshold., (Copyright © 2019 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.)- Published
- 2019
- Full Text
- View/download PDF
197. Defragmentation of lysozyme derived Amyloid β fibril using Biocompatible Magnetic fluid.
- Author
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Parikh NP and Parekh KH
- Subjects
- Animals, Cell Line, Cell Survival, Magnetic Phenomena, Protein Structure, Secondary, Amyloid beta-Peptides chemistry, Biocompatible Materials, Muramidase
- Abstract
We present here a modulating effect on lysozyme derived Amyloid β fibrils by aqueous magnetic fluid. This non-conventional approach of treatment of lysozyme derived Amyloid β fibrils showed lysing of Amyloid fibrils to its secondary structures which can be seen using optical microscope and scanning electron microscopic image. The size of lysozyme derived amyloid fibrils before and after treatment was measured using dynamic light scattering technique. The mechanism of defragmentation of lysozyme derived Amyloid β fibrils by magnetic fluid is explained. This is a first report to identify the secondary structure of protein using Fourier Transform Infrared (FTIR) and Circular Dichroism (CD) spectra after lysing. The cyto-toxicity study of this magnetic fluid on neuronal (SH-SY5Y) and non-neuronal (NRK) cell lines shows non-toxicity up to a concentration of 250 μg/mL. The study indicates a novel and unique complementary approach to treat the amyloidogenic brain diseases.
- Published
- 2018
- Full Text
- View/download PDF
198. Small round tumour cells (CD38, CD 79a positive) in the adrenal gland.
- Author
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Nigam LA, Vanikar AV, Kanodia KV, Patel RD, and Suthar KS
- Published
- 2017
- Full Text
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199. Technique to optimize magnetic response of gelatin coated magnetic nanoparticles.
- Author
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Parikh N and Parekh K
- Subjects
- Animals, Cell Line, Microscopy, Electron, Transmission, Rats, Spectroscopy, Fourier Transform Infrared, Thermogravimetry, X-Ray Diffraction, Gelatin chemistry, Magnetics, Nanoparticles
- Abstract
The paper describes the results of optimization of magnetic response for highly stable bio-functionalize magnetic nanoparticles dispersion. Concentration of gelatin during in situ co-precipitation synthesis was varied from 8, 23 and 48 mg/mL to optimize magnetic properties. This variation results in a change in crystallite size from 10.3 to 7.8 ± 0.1 nm. TEM measurement of G3 sample shows highly crystalline spherical nanoparticles with a mean diameter of 7.2 ± 0.2 nm and diameter distribution (σ) of 0.27. FTIR spectra shows a shift of 22 cm(-1) at C=O stretching with absence of N-H stretching confirming the chemical binding of gelatin on magnetic nanoparticles. The concept of lone pair electron of the amide group explains the mechanism of binding. TGA shows 32.8-25.2% weight loss at 350 °C temperature substantiating decomposition of chemically bind gelatin. The magnetic response shows that for 8 mg/mL concentration of gelatin, the initial susceptibility and saturation magnetization is the maximum. The cytotoxicity of G3 sample was assessed in Normal Rat Kidney Epithelial Cells (NRK Line) by MTT assay. Results show an increase in viability for all concentrations, the indicative probability of a stimulating action of these particles in the nontoxic range. This shows the potential of this technique for biological applications as the coated particles are (i) superparamagnetic (ii) highly stable in physiological media (iii) possibility of attaching other drug with free functional group of gelatin and (iv) non-toxic.
- Published
- 2015
- Full Text
- View/download PDF
200. Ultrasonic propagation: a technique to reveal field induced structures in magnetic nanofluids.
- Author
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Parekh K, Patel J, and Upadhyay RV
- Abstract
The paper reports the study of magnetic field induced structures in magnetic nanofluid investigated through ultrasonic wave propagation. Modified Tarapov's theory is used to study variation in velocity anisotropy with magnetic field. The types of field induced structures depend upon the chemical structure of the carrier in which magnetic nanoparticles are dispersed. Our study indicates formation of fractals and chain respectively, in transformer oil and kerosene based fluid. This difference is explained on the basis of particle-particle interaction and particle-medium interaction., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
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