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Proprioception is critical to motor control and functional status but has received limited study early after stroke. Patients admitted to an inpatient rehabilitation facility for stroke (n = 18, mean(±SD) 12.5 ± 6.6 days from stroke) and older healthy controls (n = 19) completed the Wrist Position Sense Test (WPST), a validated, quantitative measure of wrist proprioception, as well as motor and cognitive testing. Patients were serially tested when available (n = 12, mean 11 days between assessments). In controls, mean(±SD) WPST error was 9.7 ± 3.5° in the dominant wrist and 8.8 ± 3.8° in the nondominant wrist (p = 0.31). In patients with stroke, WPST error was 18.6 ± 9° in the more-affected wrist, with abnormal values present in 88.2%; and 11.5 ± 5.6° in the less-affected wrist, with abnormal values present in 72.2%. Error in the more-affected wrist was higher than in the less-affected wrist (p = 0.003) or in the dominant (p = 0.001) and nondominant (p < 0.001) wrist of controls. Age and BBT performance correlated with dominant hand WPST error in controls. WPST error in either wrist after stroke was not related to age, BBT, MoCA, or Fugl-Meyer scores. WPST error did not significantly change in retested patients. Wrist proprioception deficits are common, bilateral, and persistent in subacute stroke and not explained by cognitive or motor deficits. [ABSTRACT FROM AUTHOR]

We have synthesized a new series of 7-chloroquinoline derivatives by a single step choro-amine coupling reaction. Compounds 3a–l was tested for in vitro antitubercular and antimalarial agent. Compounds 3a and 3 b were more active than rifampicin against M. tuberculosis H37Rv and compound 3a was more active against P. falciparum strain as compared to quinine. Furthermore, compounds 3b and 3c were found to possess excellent activity as compared to quinine. These compounds could be considered as a new broad spectrum antitubercular and antimalarial agent. All the synthesized compounds were confirmed by IR, Mass, 1HNMR and 13C NMR spectroscopy. Molecular docking studies were also done subsequently, using target, shikimate kinase (2IYZ) and hypoxanthine-guanine phosphoribosyltransferase (1BZY) enzyme to find the structural requirement for activity for these series of compounds. [ABSTRACT FROM AUTHOR]

A new series of quinoline derivatives has been synthesized by two different methods. In the first methods, 6-subtituted 2-(pyridin-3/4-yloxy) quinoline-3-carbaldehyde 2 was reduced with NaBH4 in methanol and then reacted with thionylchloride in DMC to give 3 which on chloramines coupling with 1,3,4 thiadiazole derivatives to give final compounds 5a-l. In the second methods, 6-substituted 2-(pyridin-3/4-yloxy) quinoline-3-carbaldehyde formed Schiff base 4 with 1,3,4 thiadiazole derivatives which on reduction with NaBH4 in DMC give 5a-l as final compounds. The synthesized compounds were confirmed for their structure by IR, 13C NMR, ¹H NMR and mass spectroscopic methods. All the synthesized compounds were evaluated for antimicrobial activity and their bioactivity score determined by Molinspiration cheminformatics software. From all the compounds, 5b, 5h and 5l have shown significant activity as compared to standard drugs. [ABSTRACT FROM AUTHOR]