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154. AUT756787_Lay_Abstract – Supplemental material for Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood

Author

Yamna Ali, Anderson, Laura N, Smile, Sharon, Chen, Yang, Borkhoff, Cornelia M, Koroshegyi, Christine, Lebovic, Gerald, Parkin, Patricia C, Birken, Catherine S, Szatmari, Peter, and Maguire, Jonathon L

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, FOS: Educational sciences, 110319 Psychiatry (incl. Psychotherapy), FOS: Health sciences, humanities, 130312 Special Education and Disability, Education
Abstract

Supplemental material, AUT756787_Lay_Abstract for Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood by Yamna Ali, Laura N Anderson, Sharon Smile, Yang Chen, Cornelia M Borkhoff, Christine Koroshegyi, Gerald Lebovic, Patricia C Parkin, Catherine S Birken, Peter Szatmari and Jonathon L Maguire; on behalf of the TARGet Kids! Collaboration in Autism

Published
2018
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155. A Positive Association Between Dietary Intake of Higher Cow's Milk-Fat Percentage and Non−High-Density Lipoprotein Cholesterol in Young Children

Author

Wong, Vincent C.H., primary, Maguire, Jonathon L., additional, Omand, Jessica A., additional, Dai, David W.H., additional, Lebovic, Gerald, additional, Parkin, Patricia C., additional, O'Connor, Deborah L., additional, Birken, Catherine S., additional, Cohn, Ronald, additional, Lau, Eddy, additional, Laupacis, Andreas, additional, Salter, Michael, additional, Szatmari, Peter, additional, Weir, Shannon, additional, Anderson, Laura N., additional, Borkhoff, Cornelia M., additional, Keown-Stoneman, Charles, additional, Kowal, Christine, additional, Mason, Dalah, additional, Abdurrahman, Murtala, additional, Anderson, Kelly, additional, Arbess, Gordon, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bergeron, Sylvie, additional, Bhagat, Dimple, additional, Bloch, Gary, additional, Bonifacio, Joey, additional, Bowry, Ashna, additional, Calpin, Caroline, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Cheng, Elaine, additional, Chisamore, Brian, additional, Constantin, Evelyn, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Doukas, Kathleen, additional, Egger, Anne, additional, Farber, Allison, additional, Freedman, Amy, additional, Freeman, Sloane, additional, Gazeley, Sharon, additional, Guiang, Charlie, additional, Ha, Dan, additional, Handford, Curtis, additional, Hanson, Laura, additional, Harrington, Leah, additional, Jacobson, Sheila, additional, Jagiello, Lukasz, additional, Jansz, Gwen, additional, Kadar, Paul, additional, Kim, Florence, additional, Kiran, Tara, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Leduc, Denis, additional, Leung, Fok-Han, additional, Li, Alan, additional, Li, Patricia, additional, Malach, Jessica, additional, Male, Roy, additional, Mascoll, Vashti, additional, Meret, Aleks, additional, Mok, Elise, additional, Moodie, Rosemary, additional, Nader, Maya, additional, Nash, Katherine, additional, Naymark, Sharon, additional, Owen, James, additional, Peer, Michael, additional, Pena, Kifi, additional, Perlmutar, Marty, additional, Persaud, Navindra, additional, Pinto, Andrew, additional, Porepa, Michelle, additional, Qi, Vikky, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Raza, Danyaal, additional, Rosenthal, Alana, additional, Rouleau, Katherine, additional, Ruderman, Caroline, additional, Saunderson, Janet, additional, Schiralli, Vanna, additional, Sgro, Michael, additional, Shuja, Hafiz, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Srikanthan, Cinntha, additional, Taylor, Carolyn, additional, Treherne, Stephen, additional, Turner, Suzanne, additional, Uddin, Fatima, additional, van den Heuvel, Meta, additional, Vaughan, Joanne, additional, Weisdorf, Thea, additional, Wijayasinghe, Sheila, additional, Wong, Peter, additional, Yaremko, John, additional, Ying, Ethel, additional, Young, Elizabeth, additional, Zajdman, Michael, additional, Bazeghi, Farnaz, additional, Bouchard, Vincent, additional, Bustos, Marivic, additional, Camacho, Charmaine, additional, Dalwadi, Dharma, additional, Koroshegyi, Christine, additional, Malhi, Tarandeep, additional, Thadani, Sharon, additional, Thompson, Julia, additional, Thompson, Laurie, additional, Aglipay, Mary, additional, Bayoumi, Imaan, additional, Carsley, Sarah, additional, Cost, Katherine, additional, Eny, Karen, additional, Kim, Theresa, additional, Kinlin, Laura, additional, Omand, Jessica, additional, Vanderhout, Shelley, additional, Vanderloo, Leigh, additional, Allen, Christopher, additional, Boodhoo, Bryan, additional, Chan, Olivia, additional, Hall, Judith, additional, Juni, Peter, additional, Pope, Karen, additional, Thorpe, Kevin, additional, Kandel, Rita, additional, Rodrigues, Michelle, additional, and Vandenberghe, Hilde, additional

Published
2019
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160. Higher Body Mass Index Is Associated with Iron Deficiency in Children 1 to 3 Years of Age

Author

Sypes, Emma E., primary, Parkin, Patricia C., additional, Birken, Catherine S., additional, Carsley, Sarah, additional, MacArthur, Colin, additional, Maguire, Jonathon L., additional, Borkhoff, Cornelia M., additional, Aglipay, Mary, additional, Anderson, Laura N., additional, Dai, David W.H., additional, Keown-Stoneman, Charles, additional, Kowal, Christine, additional, Mason, Dalah, additional, Abdurrahman, Murtala, additional, Anderson, Barbara, additional, Anderson, Kelly, additional, Arbess, Gordon, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bayoumi, Imaan, additional, Bergeron, Sylvie, additional, Bhagat, Dimple, additional, Blanchette, Nicholas, additional, Bloch, Gary, additional, Bonifacio, Joey, additional, Bowry, Ashna, additional, Brown, Anne, additional, Bugera, Jennifer, additional, Calpin, Caroline, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Cheng, Elaine, additional, Chisamore, Brian, additional, Constantin, Evelyn, additional, Culbert, Ellen, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Dorey, Michael, additional, Doukas, Kathleen, additional, Egger, Anne, additional, Farber, Allison, additional, Freedman, Amy, additional, Freeman, Sloane, additional, Gazeley, Sharon, additional, Guiang, Charlie, additional, Ha, Dan, additional, Handford, Curtis, additional, Hanson, Laura, additional, Harrington, Leah, additional, Hatch, Hailey, additional, Hughes, Teresa, additional, Jacobson, Sheila, additional, Jagiello, Lukasz, additional, Jansz, Gwen, additional, Jasuja, Mona, additional, Kadar, Paul, additional, Kiran, Tara, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Lau, Eddy, additional, Leduc, Denis, additional, Leung, Fok-Han, additional, Li, Alan, additional, Li, Patricia, additional, Loo, Jennifer, additional, Louis, Joanne, additional, Mahmoud, Sarah, additional, Malach, Jessica, additional, Male, Roy, additional, Mascoll, Vashti, additional, Meret, Aleks, additional, Mok, Elise, additional, Moodie, Rosemary, additional, Morinis, Julia, additional, Nader, Maya, additional, Nash, Katherine, additional, Naymark, Sharon, additional, Owen, James, additional, Parry, Jane, additional, Peer, Michael, additional, Pena, Kifi, additional, Perlmutar, Marty, additional, Persaud, Navindra, additional, Pinto, Andrew, additional, Porepa, Michelle, additional, Qi, Vikky, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Rana, Jesleen, additional, Raza, Danyaal, additional, Rosenthal, Alana, additional, Rouleau, Katherine, additional, Saunderson, Janet, additional, Saxena, Rahul, additional, Schiralli, Vanna, additional, Sgro, Michael, additional, Shuja, Hafiz, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Srikanthan, Cinntha, additional, Taylor, Carolyn, additional, Treherne, Stephen, additional, Turner, Suzanne, additional, Uddin, Fatima, additional, van den Heuvel, Meta, additional, Vaughan, Joanne, additional, Weisdorf, Thea, additional, Wijayasinghe, Sheila, additional, Wong, Peter, additional, Wormsbecker, Anne, additional, Yaremko, John, additional, Ying, Ethel, additional, Young, Elizabeth, additional, Zajdman, Michael, additional, Bazeghi, Farnaz, additional, Bouchard, Vincent, additional, Bustos, Marivic, additional, Camacho, Charmaine, additional, Dalwadi, Dharma, additional, Koroshegyi, Christine, additional, Malhi, Tarandeep, additional, Thadani, Sharon, additional, Thompson, Julia, additional, and Thompson, Laurie, additional

Published
2019
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161. Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood.

Author

Ali, Yamna, Anderson, Laura N, Smile, Sharon, Chen, Yang, Borkhoff, Cornelia M, Koroshegyi, Christine, Lebovic, Gerald, Parkin, Patricia C, Birken, Catherine S, Szatmari, Peter, Maguire, Jonathon L, Birken, Catherine S., Maguire, Jonathon L., Lau, Eddy, Laupacis, Andreas, Parkin, Patricia C., Salter, Michael, Weir, Shannon, Anderson, Laura N., and Borkhoff, Cornelia M.

Subjects
DIAGNOSIS of autism, THERAPEUTIC use of vitamin D, AUTISM risk factors, AGE distribution, CONFIDENCE intervals, DIETARY supplements, ETHNIC groups, INCOME, LONGITUDINAL method, MEDICAL records, POISSON distribution, SELF-evaluation, SEX distribution, VITAMIN D, VITAMIN D deficiency, RELATIVE medical risk, ATTITUDES of mothers, PARENT attitudes, DISEASE incidence, FAMILY history (Medicine), PHYSICIANS' attitudes, DISEASE complications, CHILDREN
Abstract

Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses – a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence = 1.1%) over the observation period (average follow-up time = 2.5 years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk = 1.04, 95% confidence interval: 0.97, 1.11 per 10 nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk = 1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk = 0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder. [ABSTRACT FROM AUTHOR]

Published
2019
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169. Body Weight at Age Four Years and Readiness to Start School: A Prospective Cohort Study

Author

Omand, Jessica A., Li, Xuedi, Keown-Stoneman, Charles D.G., Borkhoff, Cornelia M., Duku, Eric, Lebovic, Gerald, Maguire, Jonathon L., Mamdani, Muhammad M., Parkin, Patricia C., Reid-Westoby, Caroline, Randall Simpson, Janis, Tremblay, Mark S., Janus, Magdalena, and Birken, Catherine S.

Abstract

Background:Adolescents with obesity have lower academic performance, but little is known about the association between body weight in early childhood and school readiness. The objective was to examine the association between age- and sex-standardized body mass index (zBMI) and body weight status and school readiness in young children.Methods:A prospective cohort study in Toronto, Canada, was conducted in young children enrolled in TARGet Kids!. Children's weight and height were measured before the start of kindergarten. Children's school readiness was measured by the Early Development Instrument (EDI), a validated teacher-completed instrument that assesses children's skills and behaviors in five developmental domains in kindergarten. Generalized estimating equations, adjusted for relevant confounders, were used in the analysis.Results:The study included 1015 children (1217 observations): 52% were male and mean age at zBMI was 4.2 years [50 months (SD 12.1)] and school readiness was 5.2 years [62.7 months (SD 6.9)]. There was no evidence found that zBMI was associated with school readiness. However, in a post hocanalysis, being classified as overweight or with obesity in kindergarten was associated with twofold higher odds of vulnerability in school readiness and a lower social competence score compared with their normal weight peers.Conclusions:Being classified as overweight or with obesity was associated with poor school readiness in year 2 of kindergarten. Early interventions to promote healthy growth before school entry may help promote development and school readiness in young children. www.clinicaltrials.gov(NCT01869530).

Published
2024
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170. The association between body mass index trajectories and cardiometabolic risk in young children.

Author

Li, Xuedi, Keown‐Stoneman, Charles D.G., Lebovic, Gerald, Omand, Jessica A., Adeli, Khosrow, Hamilton, Jill K., Hanley, Anthony J., Mamdani, Muhammad, McCrindle, Brian W., Sievenpiper, John L., Tremblay, Mark S., Maguire, Jonathon L., Parkin, Patricia C., and Birken, Catherine S.

Subjects
BLOOD sugar analysis, AGE distribution, BLOOD pressure, BODY weight, CARDIOVASCULAR diseases risk factors, CONFIDENCE intervals, HIGH density lipoproteins, HUMAN growth, LONGITUDINAL method, METABOLIC disorders, CHILDHOOD obesity, REGRESSION analysis, RISK assessment, SEX distribution, STATURE, TRIGLYCERIDES, BODY mass index, STRUCTURAL equation modeling, WAIST circumference, DISEASE complications, DISEASE risk factors, CHILDREN
Abstract

Summary: Background: Rapid growth is associated with increased cardiometabolic risk (CMR) in adolescence and adulthood. Little is known about whether the association between rapid growth and increased CMR originates in early childhood. Objectives: To identify age and sex standardized body mass index (zBMI) trajectories and to examine the association between zBMI trajectories and CMR outcomes in children 0 to 60 months. Study design A longitudinal cohort study was conducted through The Applied Research Group for Kids (TARGet Kids!) in Toronto, Canada. Participants had repeated measures of weight and length or height performed from birth to 60 months of age. Latent class mixed modelling was used to identify the zBMI trajectories. Linear regressions were performed to determine the association between zBMI trajectories and the primary outcome, a CMR score, quantified as the sum of age‐ and sex‐ standardized waist circumference, systolic blood pressure, glucose, log‐triglycerides and negative high‐density lipoprotein cholesterol (HDL‐C), divided by √5. Secondary outcomes were the individual components of the CMR formula as well as diastolic blood pressure and non‐HDL‐C. Results: Four BMI trajectories were identified among the 1166 children. After adjusting for all covariates, children in the rapidly accelerating trajectory had increased total CMR score (β = 1.38, 95% CI 0.77; 1.99, P <.001) and increased waist circumference score (β = 2.39, 95% CI 1.92; 2.86, P <.001) compared to the stable low group. Conclusions: Rapid growth during early childhood is associated with increased CMR in preschool children, largely driven by larger waist circumference. [ABSTRACT FROM AUTHOR]

Published
2020
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171. The association between screen time and cardiometabolic risk in young children.

Author

Sivanesan, Harunya, Vanderloo, Leigh M., Keown-Stoneman, Charles D. G., Parkin, Patricia C., Maguire, Jonathon L., and Birken, Catherine S.

Subjects
BLOOD sugar analysis, BLOOD pressure, BODY weight, CARDIOVASCULAR diseases risk factors, CONFIDENCE intervals, HIGH density lipoproteins, METABOLIC disorders, RISK assessment, TRIGLYCERIDES, EVIDENCE-based medicine, PROFESSIONAL practice, MULTIPLE regression analysis, SEDENTARY lifestyles, PHYSICAL activity, WAIST circumference, SCREEN time, DISEASE risk factors, CHILDREN
Abstract

Objectives: While studies exist on the association between screen time and cardiometabolic risk among adolescents, research examining the effect of screen time on cardiometabolic risk in young children is lacking. The primary objective of this study was to examine the association between daily screen time and cardiometabolic risk (CMR) [sum of age- and sex-standardized z-scores of systolic blood pressure (SBP), glucose, log-triglycerides, waist circumference (WC), and negative high-density lipoprotein (HDL) cholesterol divided by the square root of five] in young children. Secondary objectives included examining individual CMR risk factors, including waist-to-height ratio and non high-density lipoprotein (non-HDL) cholesterol, as well as the individual cut-offs of these risk factors. Additional analyses include examining the association between screen time and CMR by handheld/non-handheld devices. Methods: A study was conducted among young children 3 to 6 years from the TARGet Kids! practice-based research network in Toronto and Montreal, Canada. Children with one or more measures of screen time and CMR were included in this study. Generalized estimating equation (GEE) multivariable linear regressions and multivariable logistic regressions, using published cut-offs, were conducted to evaluate these associations. Results: Data from 1317 children [mean age 52 months (SD = 13.36), 44.34% female] were included for analyses. There was no evidence of associations between screen time and total CMR score or individual risk factors (p > 0.05) after adjusting for confounders. A statistically significant, but small association between daily screen time and non-HDL cholesterol was found (B = 0.046; CI = [0.017 to 0.075]; p = 0.002. Conclusions: Though no relationship was reported between daily screen time and the majority of CMR factors in early childhood, there was an association between daily screen time and non-HDL cholesterol. As the relationship between daily screen time and CMR factors may not be apparent in early childhood, studies to evaluate longer-term cardiometabolic effects of screen time are needed. Although there is an evidence-based rationale to reduce screen time in early childhood, prevention of cardiometabolic risk may not be the primary driver. [ABSTRACT FROM AUTHOR]

Published
2020
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174. Temperament Is Associated With Outdoor Free Play in Young Children: A TARGet Kids! Study

Author

Sharp, Julia R., primary, Maguire, Jonathon L., additional, Carsley, Sarah, additional, Abdullah, Kawsari, additional, Chen, Yang, additional, Perrin, Eliana M., additional, Parkin, Patricia C., additional, Birken, Catherine S., additional, Lau, Eddy, additional, Laupacis, Andreas, additional, Salter, Michael, additional, Szatmari, Peter, additional, Weir, Shannon, additional, Aglipay, Mary, additional, Ali, Yamna, additional, Anderson, Laura N., additional, Bayoumi, Imaan, additional, Borkhoff, Cornelia M., additional, Chen, Shiyi, additional, Dai, David W.H., additional, Darmawikarta, Denise, additional, Dennis, Cindy-Lee, additional, Eny, Karen, additional, Erdle, Stephanie, additional, Furlong, Kayla, additional, Kavikondala, Kanthi, additional, Koroshegyi, Christine, additional, Kowal, Christine, additional, Lee, Grace Jieun, additional, Mason, Dalah, additional, Omand, Jessica, additional, Persaud, Navindra, additional, Plumptre, Lesley, additional, van den Heuvel, Meta, additional, Vanderhout, Shelley, additional, Wong, Peter, additional, Zabih, Weeda, additional, Abdurrahman, Murtala, additional, Anderson, Barbara, additional, Anderson, Kelly, additional, Arbess, Gordon, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bergeron, Sylvie, additional, Bhagat, Dimple, additional, Blanchette, Nicholas, additional, Bloch, Gary, additional, Bonifacio, Joey, additional, Bowry, Ashna, additional, Brown, Anne, additional, Bugera, Jennifer, additional, Calpin, Caroline, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Cheng, Elaine, additional, Chisamore, Brian, additional, Constantin, Evelyn, additional, Culbert, Erin, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Dorey, Michael, additional, Doukas, Kathleen, additional, Egger, Anne, additional, Farber, Allison, additional, Freedman, Amy, additional, Freeman, Sloane, additional, Fung, Keewai, additional, Gazeley, Sharon, additional, Goldenberg, Donna, additional, Guiang, Charlie, additional, Ha, Dan, additional, Hafiz, Shuja, additional, Handford, Curtis, additional, Hanson, Laura, additional, Harrington, Leah, additional, Hatch, Hailey, additional, Hughes, Teresa, additional, Jacobson, Sheila, additional, Jagiello, Lukasz, additional, Jansz, Gwen, additional, Kadar, Paul, additional, Kiran, Tara, additional, Kitney, Lauren, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Leung, Fok-Han, additional, Li, Alan, additional, Li, Patricia, additional, Loo, Jennifer, additional, Louis, Joanne, additional, Mahmoud, Sarah, additional, Male, Roy, additional, Mascoll, Vashti, additional, Moodie, Rosemary, additional, Morinis, Julia, additional, Nader, Maya, additional, Naymark, Sharon, additional, Neelands, Patricia, additional, Owen, James, additional, Parry, Jane, additional, Peer, Michael, additional, Pena, Kifi, additional, Perlmutar, Marty, additional, Pinto, Andrew, additional, Pitt, Tracy, additional, Porepa, Michelle, additional, Qi, Vikky, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Rana, Jesleen, additional, Rosenthal, Alana, additional, Rouleau, Katherine, additional, Saunderson, Janet, additional, Saxena, Rahul, additional, Schiralli, Vanna, additional, Sgro, Michael, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Srikanthan, Cinntha, additional, Taylor, Carolyn, additional, Turner, Suzanne, additional, Uddin, Fatima, additional, Vaughan, Joanne, additional, Weisdorf, Thea, additional, Wijayasinghe, Sheila, additional, Wormsbecker, Anne, additional, Ying, Ethel, additional, Young, Elizabeth, additional, Zajdman, Michael, additional, Bustos, Marivic, additional, Camacho, Charmaine, additional, Dalwadi, Dharma, additional, Jegathesan, Thivia, additional, Malhi, Tarandeep, additional, Thadani, Sharon, additional, Thompson, Julia, additional, Thompson, Laurie, additional, Allen, Christopher, additional, Boodhoo, Bryan, additional, Hall, Judith, additional, Juni, Peter, additional, Lebovic, Gerald, additional, Pope, Karen, additional, Shim, Jodi, additional, Thorpe, Kevin, additional, and Azad, Azar, additional

Published
2018
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176. Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial

Author

Mahant, Sanjay, primary, Wahi, Gita, additional, Giglia, Lucy, additional, Pound, Catherine, additional, Kanani, Ronik, additional, Bayliss, Ann, additional, Roy, Madan, additional, Sakran, Mahmoud, additional, Kozlowski, Natascha, additional, Breen-Reid, Karen, additional, Lavigne, Mollie, additional, Premji, Laila, additional, Moretti, Myla E, additional, Willan, Andrew R, additional, Schuh, Suzanne, additional, and Parkin, Patricia C, additional

Published
2018
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184. 46 Association of Empiric Antibiotic Selection on Clinical Outcomes in Hospitalized Children with Severe Orbital Infections: A Multicenter Cohort Study

Author

Nguyen, Emily, Mahant, Sanjay, Cichon, Jessica, Borkhoff, Cornelia M, Drouin, Olivier, Pound, Catherine, Quet, Julie, Wahi, Gita, Bayliss, Ann, Vomiero, Gemma, Foulds, Jessica, Kanani, Ronik, Sakran, Mahmoud, Sehgal, Anupam, Pullenayegum, Eleanor, Widjaja, Elysa, Reginald, Arun, Wolter, Nikolaus E, Parkin, Patricia C, Gill, Peter J, and Krueger, Carsten

Published
2023
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186. Are seat belt restraints as effective in school age children as in adults? A prospective crash study. (Papers)

Author

Halman, Stephen I., Chipman, Mary, Parkin, Patricia C., and Wright, James G.

Subjects
Automobile driving -- Safety and security measures, Motor vehicle driving -- Safety and security measures, Children -- Safety and security measures -- Injuries, Traffic accidents -- Injuries -- Safety and security measures, Health, Injuries, Safety and security measures
Abstract

Abstract Objective To study effectiveness of seat belts for protecting school age children in road vehicle crashes. Design Crash examinations by trained investigators. Setting Ten Canadian university based crash investigation [...]

Published
2002

187. Vitamin D and Fracture Risk in Early Childhood: A Case-Control Study

Author

Anderson, Laura N., Heong, Sze Wing, Chen, Yang, Thorpe, Kevin E., Adeli, Khosrow, Howard, Andrew, Sochett, Etienne, Birken, Catherine S., Parkin, Patricia C., Maguire, Jonathon L., Abdullah, Kawsari, Borkhoff, Cornelia M., Carsley, Sarah, Katz-Lavigne, Mikael, Kavikondala, Kanthi, Kowal, Christine, Mason, Dalah, Omand, Jessica, Persaud, Navindra, van den Heuvel, Meta, Baker, Jillian, Barozzino, Tony, Bonifacio, Joey, Campbell, Douglas, Cheema, Sohail, Chisamore, Brian, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Dorey, Michael, Freeman, Sloane, Fung, Keewai, Guiang, Charlie, Handford, Curtis, Hatch, Hailey, Jacobson, Sheila, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Lau, Eddy, Leung, Fok-Han, Loo, Jennifer, Mahmoud, Sarah, Moodie, Rosemary, Morinis, Julia, Naymark, Sharon, Neelands, Patricia, Owen, James, Peer, Michael, Perlmutar, Marty, Pinto, Andrew, Porepa, Michelle, Ramji, Nasreen, Ramji, Noor, Rosenthal, Alana, Saunderson, Janet, Saxena, Rahul, Sgro, Michael, Shepherd, Susan, Smiltnieks, Barbara, Taylor, Carolyn, Weisdors, Thea, Wijayasinghe, Sheila, Wong, Peter, Ying, Ethel, and Young, Elizabeth

Subjects
Male, medicine.medical_specialty, Waist, Epidemiology, Birth weight, Original Contributions, 030209 endocrinology & metabolism, Odds, 03 medical and health sciences, Eating, Fractures, Bone, 0302 clinical medicine, Risk Factors, 030225 pediatrics, Internal medicine, medicine, Vitamin D and neurology, Odds Ratio, Animals, Humans, Early childhood, Vitamin D, Ontario, business.industry, Case-control study, Infant, Odds ratio, Vitamins, Confidence interval, 3. Good health, Logistic Models, Milk, Case-Control Studies, Child, Preschool, Dietary Supplements, Female, business
Abstract

The objective of this study was to evaluate the association of vitamin D intake and serum levels with fracture risk in children under 6 years of age. A case-control study was conducted in Toronto, Ontario, Canada. Cases were recruited from the fracture clinic at the Hospital for Sick Children, and matched controls were obtained from the TARGet Kids! primary-care research network. Controls were matched to cases on age, sex, height, and season. Fracture risk was estimated from conditional logistic regression, with adjustment for skin type, fracture history, waist circumference, outdoor free play, neighborhood income, soda consumption, and child's birth weight. A total of 206 cases were recruited during May 2009–April 2013 and matched to 343 controls. Serum 25-hydroxyvitamin D concentration (per 10-nmol/L increment: adjusted odds ratio (aOR) = 0.95, 95% confidence interval (CI): 0.88, 1.03) and intake of cow's milk (2 cups/day vs. 2 cups/day: aOR = 1.39 (95% CI: 0.85, 2.23)) were not significantly associated with reduced odds of fracture. A statistically significant association was observed between child use of vitamin D supplements and decreased odds of fracture (yes vs. no: aOR = 0.42, 95% CI: 0.25, 0.69). Vitamin D supplementation, but not serum 25-hydroxyvitamin D level or milk intake, was associated with reduced fracture risk among these healthy young children.

Published
2016

191. Temperament and fracture in preschool-aged children

Author

Ryckman, Kandace, primary, Richmond, Sarah A., additional, Anderson, Laura N., additional, Birken, Catherine S., additional, Parkin, Patricia C., additional, Macarthur, Colin, additional, Maguire, Jonathon L., additional, and Howard, Andrew W., additional

Published
2017
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192. Total Breast-Feeding Duration and Dental Caries in Healthy Urban Children

Author

Wong, Peter D., primary, Birken, Catherine S., additional, Parkin, Patricia C., additional, Venu, Isvarya, additional, Chen, Yang, additional, Schroth, Robert J., additional, Maguire, Jonathon L., additional, Abdullah, Kawsari, additional, Anderson, Laura N., additional, Borkhoff, Cornelia M., additional, Carsley, Sarah, additional, Katz-Lavigne, Mikael, additional, Kavikondala, Kanthi, additional, Lee, Grace Jieun, additional, Mason, Dalah, additional, Omand, Jessica, additional, Persaud, Navindra, additional, van den Heuvel, Meta, additional, Zabih, Weeda, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bonifacio, Joey, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Chisamore, Brian, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Dorey, Michael, additional, Freeman, Sloane, additional, Fung, Keewai, additional, Guiang, Charlie, additional, Handford, Curtis, additional, Hatch, Hailey, additional, Jacobson, Sheila, additional, Kiran, Tara, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Lau, Eddy, additional, Leung, Fok-Han, additional, Loo, Jennifer, additional, Mahmoud, Sarah, additional, Moodie, Rosemary, additional, Morinis, Julia, additional, Naymark, Sharon, additional, Neelands, Patricia, additional, Owen, James, additional, Peer, Michael, additional, Perlmutar, Marty, additional, Pinto, Andrew, additional, Porepa, Michelle, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Rosenthal, Alana, additional, Saunderson, Janet, additional, Saxena, Rahul, additional, Sgro, Michael, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Taylor, Carolyn, additional, Weisdors, Thea, additional, Wijayasinghe, Sheila, additional, Wong, Peter, additional, Ying, Ethel, additional, and Young, Elizabeth, additional

Published
2017
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195. Parent reported nutritional risk and laboratory indices of cardiometabolic risk and in preschool-aged children

Author

Persaud, Navindra, primary, Ziai, Hedyeh, additional, Lebovic, Gerald, additional, Maguire, Jonathon L., additional, Khovratovich, Marina, additional, Simpson, Janis A. Randall, additional, Adeli, Khosrow, additional, Hamilton, Jill, additional, McCrindle, Brian W., additional, Parkin, Patricia C., additional, and Birken, Catherine S., additional

Published
2017
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198. Association Between Meat and Meat-Alternative Consumption and Iron Stores in Early Childhood

Author

Cox, Kelly Anne, primary, Parkin, Patricia C., additional, Anderson, Laura N., additional, Chen, Yang, additional, Birken, Catherine S., additional, Maguire, Jonathon L., additional, Macarthur, Colin, additional, Borkhoff, Cornelia M., additional, Abdullah, Kawsari, additional, Bayoumi, Imaan, additional, Carsley, Sarah, additional, Katz-Lavigne, Mikael, additional, Kavikondala, Kanthi, additional, Koroshegyi, Christine, additional, Kowal, Christine, additional, Lee, Grace Jieun, additional, Mason, Dalah, additional, Omand, Jessica, additional, Persaud, Navindra, additional, van den Heuvel, Meta, additional, Wong, Peter, additional, Zabih, Weeda, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bonifacio, Joey, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Chisamore, Brian, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Dorey, Michael, additional, Freeman, Sloane, additional, Fung, Keewai, additional, Guiang, Charlie, additional, Handford, Curtis, additional, Hatch, Hailey, additional, Jacobson, Sheila, additional, Kiran, Tara, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Lau, Eddy, additional, Leung, Fok-Han, additional, Loo, Jennifer, additional, Mahmoud, Sarah, additional, Moodie, Rosemary, additional, Morinis, Julia, additional, Naymark, Sharon, additional, Neelands, Patricia, additional, Owen, James, additional, Peer, Michael, additional, Perlmutar, Marty, additional, Pinto, Andrew, additional, Porepa, Michelle, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Rosenthal, Alana, additional, Saunderson, Janet, additional, Saxena, Rahul, additional, Sgro, Michael, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Taylor, Carolyn, additional, Weisdors, Thea, additional, Wijayasinghe, Sheila, additional, Ying, Ethel, additional, Young, Elizabeth, additional, Feldman, Mark, additional, Ipp, Moshe, additional, Abreo, Kathleen, additional, Dalwadi, Dharma, additional, Malhi, Tarandeep, additional, Pugliese, Antoinetta, additional, Smith, Megan, additional, and Thompson, Laurie, additional

Published
2016
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