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151. Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study

Author

Xu, Chunsheng, primary, Tian, Xiaocao, additional, Sun, Jianping, additional, Wu, Yili, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Li, Shuxia, additional, Petersen, Inge, additional, Mengel-From, Jonas, additional, Christiansen, Lene, additional, Christensen, Kaare, additional, and Tan, Qihua, additional

Published
2017
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153. Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Hur, Yoon-Mi, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Honda, Chika, additional, Inui, Fujio, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Tomizawa, Rie, additional, Pietiläinen, Kirsi H, additional, Rissanen, Aila, additional, Siribaddana, Sisira H, additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Piirtola, Maarit, additional, Aaltonen, Sari, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Rebato, Esther, additional, Hjelmborg, Jacob B, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Cutler, Tessa L, additional, Ordoñana, Juan R, additional, Sánchez-Romera, Juan F, additional, Colodro-Conde, Lucia, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Franz, Carol E, additional, Kremen, William S, additional, Lyons, Michael J, additional, Busjahn, Andreas, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Kandler, Christian, additional, Jang, Kerry L, additional, Gatz, Margaret, additional, Butler, David A, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Jeong, Hoe-Uk, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Dahl Aslan, Anna K, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, Tynelius, Per, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Spector, Timothy D, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas S, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Corley, Robin P, additional, Huibregtse, Brooke M, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina EM, additional, Willemsen, Gonneke, additional, Goldberg, Jack H, additional, Rasmussen, Finn, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Hopper, John L, additional, Sung, Joohon, additional, Maes, Hermine H, additional, Turkheimer, Eric, additional, Boomsma, Dorret I, additional, Sørensen, Thorkild IA, additional, and Kaprio, Jaakko, additional

Published
2017
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154. Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, Leonie H., primary, Jelenkovic, Aline, additional, Vuoksimaa, Eero, additional, Ahrenfeldt, Linda, additional, Pietiläinen, Kirsi H., additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Hur, Yoon-Mi, additional, Jeong, Hoe-Uk, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Cutler, Tessa L., additional, Kandler, Christian, additional, Jang, Kerry L., additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Pang, Zengchang, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Hjelmborg, Jacob v. B., additional, Rebato, Esther, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Busjahn, Andreas, additional, Lichtenstein, Paul, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Yokoyama, Yoshie, additional, Hopper, John L., additional, Loos, Ruth J. F., additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Silventoinen, Karri, additional, and Kaprio, Jaakko, additional

Published
2017
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159. Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study

Author

Liu, Na, primary, Pan, Xiong‐Fei, additional, Yu, Canqing, additional, Lv, Jun, additional, Guo, Yu, additional, Bian, Zheng, additional, Yang, Ling, additional, Chen, Yiping, additional, Wu, Tangchun, additional, Chen, Zhengming, additional, Pan, An, additional, Li, Liming, additional, Chen, Junshi, additional, Collins, Rory, additional, Peto, Richard, additional, Lancaster, Garry, additional, Yang, Xiaoming, additional, Williams, Alex, additional, Smith, Margaret, additional, Chang, Yumei, additional, Zhao, Guoqing, additional, Wu, Lixue, additional, Hou, Can, additional, Pang, Zengchang, additional, Wang, Shaojie, additional, Zhang, Yun, additional, Zhang, Kui, additional, Liu, Silu, additional, Zhao, Zhonghou, additional, Liu, Shumei, additional, Pang, Zhigang, additional, Feng, Weijia, additional, Wu, Shuling, additional, Yang, Liqiu, additional, Han, Huili, additional, He, Hui, additional, Pan, Xianhai, additional, Wang, Shanqing, additional, Wang, Hongmei, additional, Hao, Xinhua, additional, Chen, Chunxing, additional, Lin, Shuxiong, additional, Hu, Xiaoshu, additional, Zhou, Minghao, additional, Wu, Ming, additional, Wang, Yeyuan, additional, Hu, Yihe, additional, Ma, Liangcai, additional, Zhou, Renxian, additional, Xu, Guanqun, additional, Dong, Baiqing, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Gan, Zhigao, additional, Xu, Jiujiu, additional, Liu, Yun, additional, Wu, Xianping, additional, Gao, Yali, additional, Zhang, Ningmei, additional, Luo, Guojin, additional, Que, Xiangsan, additional, Chen, Xiaofang, additional, Ge, Pengfei, additional, He, Jian, additional, Ren, Xiaolan, additional, Zhang, Hui, additional, Mao, Enke, additional, Li, Guanzhong, additional, Li, Zhongxiao, additional, He, Jun, additional, Liu, Guohua, additional, Zhu, Baoyu, additional, Zhou, Gang, additional, Feng, Shixian, additional, Gao, Yulian, additional, He, Tianyou, additional, Jiang, Li, additional, Qin, Jianhua, additional, Sun, Huarong, additional, Liu, Liqun, additional, Yu, Min, additional, Chen, Yaping, additional, Hu, Zhixiang, additional, Hu, Jianjin, additional, Qian, Yijian, additional, Wu, Zhiying, additional, Chen, Lingli, additional, Liu, Wen, additional, Li, Guangchun, additional, Liu, Huilin, additional, Long, Xiangquan, additional, Xiong, Youping, additional, Tan, Zhongwen, additional, Xie, Xuqiu, additional, and Peng, Yunfang, additional

Published
2016
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160. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, Aline, primary, Hur, Yoon-Mi, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Siribaddana, Sisira H, additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Aaltonen, Sari, additional, Heikkilä, Kauko, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Rebato, Esther, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Maes, Hermine H, additional, Cutler, Tessa L, additional, Hopper, John L, additional, Ordoñana, Juan R, additional, Sánchez-Romera, Juan F, additional, Colodro-Conde, Lucia, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Sung, Joohon, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Franz, Carol E, additional, Kremen, William S, additional, Lyons, Michael J, additional, Busjahn, Andreas, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Kandler, Christian, additional, Jang, Kerry L, additional, Gatz, Margaret, additional, Butler, David A, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D'Ippolito, Cristina, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Jeong, Hoe-Uk, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Dahl-Aslan, Anna K, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, Tynelius, Per, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Lichtenstein, Paul, additional, Spector, Timothy D, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Bartels, Meike, additional, van Beijsterveldt, Toos CEM, additional, Willemsen, Gonneke, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Corley, Robin P, additional, Hjelmborg, Jacob v B, additional, Goldberg, Jack H, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Honda, Chika, additional, Inui, Fujio, additional, Rasmussen, Finn, additional, Huibregtse, Brooke M, additional, Boomsma, Dorret I, additional, Sørensen, Thorkild I A, additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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162. The Codatwins Project: The Cohort Description Of Collaborative Project Of Development Of Anthropometrical Measures In Twins To Study Macro-Environmental Variation In Genetic And Environmental Effects On Anthropometric Traits

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D., Tarnoki, David L., Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Burt, S. Alexandra, Klump, Kelly L., Medland, Sarah E., Montgomery, Grant W., Kandler, Christian, and McAdams, Tom A.

Abstract

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m(2)) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

Published
2015

163. Zygosity Differences In Height And Body Mass Index Of Twins From Infancy To Old Age: A Study Of The Codatwins Project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Honda, Chika, Bogl, Leonie H., Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Burt, S. Alexandra, Klump, Kelly L., Medland, Sarah E., Montgomery, Grant W., Kandler, Christian, McAdams, Tom A., Eley, Thalia C., and Gregory, Alice M.

Abstract

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m(2) in childhood and adolescence and up to 0.2 kg/m(2) in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

Published
2015

164. Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the CODATwins study

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob B., Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Fuling, Ji, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly Jane, Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin, Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Derom, Catherine, Vlietinck, Robert, Loos, Ruth, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Stazi, Maria Antonietta, Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, L. J., Maes, Hermine H., Krueger, Robert F., McGue, Matthew, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, Beijsterveldt, C. E. M. van, Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, José António, Dubois, Lise, Boivin, Michel, Brendgen, Mara Rosemarie, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik, Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot Max, Öncel, Sevgi Y., Aliev, Fazil, Spector, T. D., Mangino, Massimo, Lachance, Geneviève, Baker, Laura Ann, Tuvblad, Catherine, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob B., Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Fuling, Ji, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly Jane, Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin, Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Derom, Catherine, Vlietinck, Robert, Loos, Ruth, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Stazi, Maria Antonietta, Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, L. J., Maes, Hermine H., Krueger, Robert F., McGue, Matthew, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, Beijsterveldt, C. E. M. van, Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, José António, Dubois, Lise, Boivin, Michel, Brendgen, Mara Rosemarie, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik, Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot Max, Öncel, Sevgi Y., Aliev, Fazil, Spector, T. D., Mangino, Massimo, Lachance, Geneviève, Baker, Laura Ann, and Tuvblad, Catherine

Abstract

BACKGROUND: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. OBJECTIVES: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. DESIGN: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. RESULTS: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. CONCLUSIONS: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

Published
2016

165. Genetic and environmental influences on height from infancy to early adulthood

Author

University of Helsinki, Department of Social Research, University of Helsinki, Department of Public Health, University of Helsinki, Clinicum, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sorensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, University of Helsinki, Department of Social Research, University of Helsinki, Department of Public Health, University of Helsinki, Clinicum, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sorensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

166. Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age:A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Author

Yokoyama, Yoshie, Jelenkovic, Aline, Sund, Reijo, Sung, Joohon, Hopper, John L, Ooki, Syuichi, Heikkilä, Kauko, Aaltonen, Sari, Tarnoki, Adam D, Tarnoki, David L, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos C E M, Saudino, Kimberly J, Cutler, Tessa L, Nelson, Tracy L, Whitfield, Keith E, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Jeong, Hoe-Uk, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Ji, Fuling, Ning, Feng, Pang, Zengchang, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Tynelius, Per, Haworth, Claire M A, Plomin, Robert, Rebato, Esther, Rose, Richard J, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Sørensen, Thorkild I A, Boomsma, Dorret I, Kaprio, Jaakko, Silventoinen, Karri, Yokoyama, Yoshie, Jelenkovic, Aline, Sund, Reijo, Sung, Joohon, Hopper, John L, Ooki, Syuichi, Heikkilä, Kauko, Aaltonen, Sari, Tarnoki, Adam D, Tarnoki, David L, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos C E M, Saudino, Kimberly J, Cutler, Tessa L, Nelson, Tracy L, Whitfield, Keith E, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Jeong, Hoe-Uk, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Ji, Fuling, Ning, Feng, Pang, Zengchang, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Tynelius, Per, Haworth, Claire M A, Plomin, Robert, Rebato, Esther, Rose, Richard J, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Sørensen, Thorkild I A, Boomsma, Dorret I, Kaprio, Jaakko, and Silventoinen, Karri

Abstract

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

Published
2016

167. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, Aline, Hur, Yoon-Mi, Sund, Reijo, Yokoyama, Yoshie, Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Aaltonen, Sari, Heikkila, Kauko, Oncel, Sevgi Y., Aliev, Fazil, Rebato, Esther, Tarnoki, Adam D., Tarnoki, David L., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Cutler, Tessa L., Hopper, John L., Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Sun, Joohon, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Franz, Carol E., Kremen, William S., Lyons, Michael J., Busjahn, Andreas, Nelson, Tracy L., Whitfield, Keith E., Kandler, Christian, Jang, Kerry L., Gatz, Margaret, Butler, David A., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Duncan, Glen E., Buchwald, Dedra, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Jeong, Hoe-Uk, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik K. E., Pedersen, Nancy L., Dahl-Aslan, Anna K., McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., Tynelius, Per, Baker, Laura A., Tuvblad, Catherine, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Lichtenstein, Paul, Spector, Timothy D., Mangino, Massimo, Lachance, Genevieve, Bartels, Meike, van Beijsterveldt, Toos C. E. M., Willemsen, Gonneke, Burt, S. Alexandra, Klump, Kelly L., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas Sevenius, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Corley, Robin P., Hjelmborg, Jacob v B., Goldberg, Jack H., Iwatani, Yoshinori, Watanabe, Mikio, Honda, Chika, Inui, Fujio, Rasmussen, Finn, Huibregtse, Brooke M., Boomsma, Dorret I., Sørensen, Thorkild I.A., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Hur, Yoon-Mi, Sund, Reijo, Yokoyama, Yoshie, Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Aaltonen, Sari, Heikkila, Kauko, Oncel, Sevgi Y., Aliev, Fazil, Rebato, Esther, Tarnoki, Adam D., Tarnoki, David L., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Cutler, Tessa L., Hopper, John L., Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Sun, Joohon, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Franz, Carol E., Kremen, William S., Lyons, Michael J., Busjahn, Andreas, Nelson, Tracy L., Whitfield, Keith E., Kandler, Christian, Jang, Kerry L., Gatz, Margaret, Butler, David A., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Duncan, Glen E., Buchwald, Dedra, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Jeong, Hoe-Uk, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik K. E., Pedersen, Nancy L., Dahl-Aslan, Anna K., McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., Tynelius, Per, Baker, Laura A., Tuvblad, Catherine, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Lichtenstein, Paul, Spector, Timothy D., Mangino, Massimo, Lachance, Genevieve, Bartels, Meike, van Beijsterveldt, Toos C. E. M., Willemsen, Gonneke, Burt, S. Alexandra, Klump, Kelly L., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas Sevenius, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Corley, Robin P., Hjelmborg, Jacob v B., Goldberg, Jack H., Iwatani, Yoshinori, Watanabe, Mikio, Honda, Chika, Inui, Fujio, Rasmussen, Finn, Huibregtse, Brooke M., Boomsma, Dorret I., Sørensen, Thorkild I.A., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886–1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

Published
2016

168. Genetic and environmental effects on body mass index from infancy to the onset of adulthood:an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob vB, Møller, Søren, Ooki, Syuichi, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, Jose Antonio, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik K. E., Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Oncel, Sevgi Y., Aliev, Fazil, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob vB, Møller, Søren, Ooki, Syuichi, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, Jose Antonio, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik K. E., Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Oncel, Sevgi Y., Aliev, Fazil, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., and Kaprio, Jaakko

Abstract

Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different e, Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

Published
2016

169. Genetic and environmental influences on height from infancy to early adulthood:An individual-based pooled analysis of 45 twin cohorts

Author

Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Möller, Sören, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Möller, Sören, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

170. Author response: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, Aline, primary, Hur, Yoon-Mi, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Siribaddana, Sisira H, additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Aaltonen, Sari, additional, Heikkilä, Kauko, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Rebato, Esther, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Maes, Hermine H, additional, Cutler, Tessa L, additional, Hopper, John L, additional, Ordoñana, Juan R, additional, Sánchez-Romera, Juan F, additional, Colodro-Conde, Lucia, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Sung, Joohon, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Franz, Carol E, additional, Kremen, William S, additional, Lyons, Michael J, additional, Busjahn, Andreas, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Kandler, Christian, additional, Jang, Kerry L, additional, Gatz, Margaret, additional, Butler, David A, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D'Ippolito, Cristina, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Jeong, Hoe-Uk, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Dahl-Aslan, Anna K, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, Tynelius, Per, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Lichtenstein, Paul, additional, Spector, Timothy D, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Bartels, Meike, additional, van Beijsterveldt, Toos CEM, additional, Willemsen, Gonneke, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Corley, Robin P, additional, Hjelmborg, Jacob v B, additional, Goldberg, Jack H, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Honda, Chika, additional, Inui, Fujio, additional, Rasmussen, Finn, additional, Huibregtse, Brooke M, additional, Boomsma, Dorret I, additional, Sørensen, Thorkild I A, additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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171. Methylation loci associated with body mass index, waist circumference, and waist-to-hip ratio in Chinese adults: an epigenome-wide analysis

Author

Wang, Biqi, primary, Gao, Wenjing, additional, Li, Jun, additional, Yu, Canqing, additional, Cao, Weihua, additional, Lv, Jun, additional, Pang, Zengchang, additional, Cong, Liming, additional, Wang, Hua, additional, Wu, Xianping, additional, Liang, Liming, additional, Wu, Tangchun, additional, and Li, Liming, additional

Published
2016
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173. Phenotypic and Genetic Correlations Between the Lobar Segments of the Inferior Fronto-occipital Fasciculus and Attention

Author

Leng, Yuan, primary, Shi, Yonggang, additional, Yu, Qiaowen, additional, Van Horn, John Darrell, additional, Tang, Haiyan, additional, Li, Junning, additional, Xu, Wenjian, additional, Ge, Xinting, additional, Tang, Yuchun, additional, Han, Yan, additional, Zhang, Dong, additional, Xiao, Min, additional, Zhang, Huaqiang, additional, Pang, Zengchang, additional, Toga, Arthur W., additional, and Liu, Shuwei, additional

Published
2016
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174. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Hur, Yoon-Mi, additional, Yokoyama, Yoshie, additional, Honda, Chika, additional, Hjelmborg, Jacob vB, additional, Möller, Sören, additional, Ooki, Syuichi, additional, Aaltonen, Sari, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Kandler, Christian, additional, Saudino, Kimberly J, additional, Jang, Kerry L, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Gao, Wenjing, additional, Yu, Canqing, additional, Li, Liming, additional, Corley, Robin P, additional, Huibregtse, Brooke M, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Heikkilä, Kauko, additional, Wardle, Jane, additional, Llewellyn, Clare H, additional, Fisher, Abigail, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Maes, Hermine H, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A, additional, Bartels, Meike, additional, van Beijsterveldt, Toos CEM, additional, Craig, Jeffrey M, additional, Saffery, Richard, additional, Freitas, Duarte L, additional, Maia, José Antonio, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Chong, Youngsook, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Tynelius, Per, additional, Lichtenstein, Paul, additional, Haworth, Claire MA, additional, Plomin, Robert, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Harden, K Paige, additional, Tucker-Drob, Elliot M, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Willemsen, Gonneke, additional, Rasmussen, Finn, additional, Goldberg, Jack H, additional, Sørensen, Thorkild IA, additional, Boomsma, Dorret I, additional, and Kaprio, Jaakko, additional

Published
2016
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175. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Hur, Yoon-Mi, additional, Yokoyama, Yoshie, additional, Hjelmborg, Jacob v. B., additional, Möller, Sören, additional, Honda, Chika, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Ooki, Syuichi, additional, Aaltonen, Sari, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Kandler, Christian, additional, Saudino, Kimberly J., additional, Jang, Kerry L., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Gao, Wenjing, additional, Yu, Canqing, additional, Li, Liming, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Heikkilä, Kauko, additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A., additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Tynelius, Per, additional, Lichtenstein, Paul, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Willemsen, Gonneke, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Christensen, Kaare, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Rasmussen, Finn, additional, Goldberg, Jack H., additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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177. The association of cigarette smoking and alcohol drinking with body mass index: a cross-sectional, population-based study among Chinese adult male twins

Author

Liao, Chunxiao, primary, Gao, Wenjing, additional, Cao, Weihua, additional, Lv, Jun, additional, Yu, Canqing, additional, Wang, Shengfeng, additional, Zhou, Bin, additional, Pang, Zengchang, additional, Cong, Liming, additional, Dong, Zhong, additional, Wu, Fan, additional, Wang, Hua, additional, Wu, Xianping, additional, Jiang, Guohong, additional, Wang, Xiaojie, additional, Wang, Binyou, additional, and Li, Liming, additional

Published
2016
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178. Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Author

Yokoyama, Yoshie, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Sung, Joohon, additional, Hopper, John L., additional, Ooki, Syuichi, additional, Heikkilä, Kauko, additional, Aaltonen, Sari, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Saudino, Kimberly J., additional, Cutler, Tessa L., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Jeong, Hoe-Uk, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Harris, Jennifer R., additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Tynelius, Per, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Rebato, Esther, additional, Rose, Richard J., additional, Goldberg, Jack H., additional, Rasmussen, Finn, additional, Hur, Yoon-Mi, additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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180. Physical activity attenuates genetic effects on BMI: Results from a study of Chinese adult twins

Author

Wang, Biqi, primary, Gao, Wenjing, additional, Lv, Jun, additional, Yu, Canqing, additional, Wang, Shengfeng, additional, Pang, Zengchang, additional, Cong, Liming, additional, Dong, Zhong, additional, Wu, Fan, additional, Wang, Hua, additional, Wu, Xianping, additional, Jiang, Guohong, additional, Wang, Xiaojie, additional, Wang, Binyou, additional, Cao, Weihua, additional, and Li, Liming, additional

Published
2016
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181. The CODATwins Project:The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D, Tarnoki, David L, Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Hong, Changhee, Chong, Youngsook, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Rasmussen, Finn, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Boomsma, Dorret I, Hur, Yoon-Mi, Sørensen, Thorkild I A, Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D, Tarnoki, David L, Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Hong, Changhee, Chong, Youngsook, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Rasmussen, Finn, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Boomsma, Dorret I, Hur, Yoon-Mi, Sørensen, Thorkild I A, and Kaprio, Jaakko

Abstract

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes., For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

Published
2015

182. Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age:A Study of the CODATwins Project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Honda, Chika, Bogl, Leonie H, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Tarnoki, Adam D, Tarnoki, David L, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Kim, Bia, Chong, Youngsook, Hong, Changhee, Shin, Hyun Jung, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Boomsma, Dorret I, Sørensen, Thorkild I A, Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Honda, Chika, Bogl, Leonie H, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Tarnoki, Adam D, Tarnoki, David L, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Kim, Bia, Chong, Youngsook, Hong, Changhee, Shin, Hyun Jung, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Boomsma, Dorret I, Sørensen, Thorkild I A, Kaprio, Jaakko, and Silventoinen, Karri

Abstract

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

Published
2015

184. Heritability of eleven metabolic phenotypes in Danish and Chinese twins:A cross-population comparison

Author

Li, Shuxia, Duan, Hongmei, Pang, Zengchang, Zhang, Dongfeng, Duan, Haiping, von Bornemann Hjelmborg, Jacob, Tan, Qihua, Kruse, Torben A, and Kyvik, Kirsten O

Abstract

A twin-based comparative study on the genetic influences in metabolic endophenotypes in two populations of substantial ethnic, environmental, and cultural differences was performed. Design and Methods: Data on 11 metabolic phenotypes including anthropometric measures, blood glucose, and lipids levels as well as blood pressure were available from 756 pairs of Danish twins (309 monozygotic and 447 dizygotic twin pairs) with a mean age of 38 years (range: 18-67) and from 325 pairs of Chinese twins (183 monozygotic and 142 dizygotic twin pairs) with a mean age of 40.5 years (range: 18-69). Twin modeling was performed on full and nested models with the best fitting models selected. Results: Heritability estimates were compared between Danish and Chinese samples to identify differential genetic influences on each of the phenotypes. Except for hip circumference, all other body measures exhibited similar heritability patterns in the two samples with body weight showing only a slight difference. Higher genetic influences were estimated for fasting blood glucose level in Chinese twins, whereas the Danish twins showed more genetic regulation over most lipids phenotypes. Systolic blood pressure was more genetically controlled in Danish than in Chinese twins. Conclusions: Metabolic endophenotypes show disparity in their genetic determinants in populations under distinct environmental conditions.

Published
2013
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185. Association of famine exposure during early life with the risk of type 2 diabetes in adulthood: a meta-analysis.

Author

Liu, Li, Wang, Weijing, Sun, Jianping, and Pang, Zengchang

Subjects
PREVENTION of malnutrition, TYPE 2 diabetes prevention, TYPE 2 diabetes risk factors, MALNUTRITION, CONFIDENCE intervals, FOOD supply, MEDICAL information storage & retrieval systems, MATERNAL-fetal exchange, MEDLINE, META-analysis, NATURAL disasters, SCIENTIFIC observation, ONLINE information services, SYSTEMATIC reviews, RELATIVE medical risk, DISEASE complications, ADULTS
Abstract

Purpose: The association between famine exposure (defined as lengthy and continuous deprivation of food) during early life and type 2 diabetes (T2DM) in adulthood remains controversial. A meta-analysis was performed to better clarify the relation of famine exposure to later T2DM risk.Methods: A systematic literature search was performed in PubMed, Web of Science, Embase and China National Knowledge Infrastructure for relevant available articles. The articles were limited to those in English or Chinese from January 1990 to June 2016. Observational studies evaluating the association between famine exposure and T2DM were included. The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of famine exposure on T2DM. The I2 was used to assess heterogeneity, and the random effects model (REM) was adopted as the pooling method.Results: We included 11 published articles with 12391 T2DM cases for this meta-analysis. A significant association of early life famine exposure with increased risk of T2DM was observed (RR = 1.38, 95% CI 1.17-1.63; I2 = 63.4%; Pheterogeneity = 0.002). Compared with the unexposed, the RRs of T2DM were 1.36 (95% CI 1.12-1.65) for fetal-infant exposed and 1.40 (95% CI 0.98-1.99) for childhood exposed. After excluding one article that had a strong effect on heterogeneity, the pooled RR was 1.46 (95% CI 1.27-1.69).Conclusion: The meta-analysis indicates that famine exposure during early life especially fetal-infant exposure may increase the risk of T2DM in adulthood. Measures should be taken to prevent malnutrition during important stages of growth and development to reduce the prevalence of T2DM. [ABSTRACT FROM AUTHOR]

Published
2018
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186. Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study.

Author

Xu, Chunsheng, Tian, Xiaocao, Sun, Jianping, Wu, Yili, Zhang, Dongfeng, Pang, Zengchang, Li, Shuxia, Petersen, Inge, Mengel‐From, Jonas, Christiansen, Lene, Christensen, Kaare, and Tan, Qihua

Subjects
BLOOD pressure, CARDIOVASCULAR diseases risk factors, CHOLESTEROL, COGNITION, GENETICS, GLUCOSE, HIGH density lipoproteins, LOW density lipoproteins, STATISTICS, TRIGLYCERIDES, BODY mass index
Abstract

Abstract: Aim: To explore the genetic and environmental influences on cardiovascular risk factors (CVRF) and cognitive function in the world's largest and rapidly aging Chinese population. Methods: Cognitive function and CVRF, including body mass index, systolic blood pressure, diastolic blood pressure, pulse pressure, glucose, total cholesterol, triglyceride, high‐density lipoprotein cholesterol (HDLC) and low‐density lipoprotein cholesterol were measured in 379 complete twin pairs. Univariate and bivariate twin models were fitted to estimate the genetic and environmental components in the variance and covariance of CVRF and cognition. Results: Mild‐to‐high heritability was estimated for CVRF and cognition (0.27–0.74). Unique environmental factors showed low‐to‐moderate contributions (0.23–0.56). Only HDLC presented significant common environmental contribution (0.50). Bivariate analysis showed significantly negative genetic correlations (rG) between cognition and systolic blood pressure (rG = −0.56), diastolic blood pressure (rG = −0.42), pulse pressure (rG = −0.45), and positive genetic correlations between cognition and total cholesterol (rG = 0.33), triglyceride (rG = 0.23) and HDLC (rG = 0.41). HDLC and cognition presented a unique environmental correlation (rE = −0.13), but in the opposite direction. Conclusions: Cognitive function was genetically related to systolic blood pressure, diastolic blood pressure, pulse pressure, total cholesterol, triglyceride and HDLC with a negative or positive direction. Cognition and HDLC might share part of a similar unique environmental factor. Geriatr Gerontol Int 2018; 18: 352–359. [ABSTRACT FROM AUTHOR]

Published
2018
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189. Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample

Author

Liu, Qingqing, primary, Yu, Canqing, additional, Gao, Wenjing, additional, Cao, Weihua, additional, Lyu, Jun, additional, Wang, Shengfeng, additional, Pang, Zengchang, additional, Cong, Liming, additional, Dong, Zhong, additional, Wu, Fan, additional, Wang, Hua, additional, Wu, Xianping, additional, Jiang, Guohong, additional, Wang, Binyou, additional, and Li, Liming, additional

Published
2015
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190. Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Author

Jelenkovic, Aline, primary, Yokoyama, Yoshie, additional, Sund, Reijo, additional, Honda, Chika, additional, Bogl, Leonie H, additional, Aaltonen, Sari, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Kandler, Christian, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Gatz, Margaret, additional, Butler, David A., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Freitas, Duarte L, additional, Maia, José Antonio, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Kim, Bia, additional, Chong, Youngsook, additional, Hong, Changhee, additional, Shin, Hyun Jung, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Chang, Billy, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Aujard, Kelly, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Heikkilä, Kauko, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Jang, Kerry L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Tynelius, Per, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Ooki, Syuichi, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Inui, Fujio, additional, Watanabe, Mikio, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Rebato, Esther, additional, Martin, Nicholas G., additional, Iwatani, Yoshinori, additional, Hayakawa, Kazuo, additional, Sung, Joohon, additional, Harris, Jennifer R., additional, Willemsen, Gonneke, additional, Busjahn, Andreas, additional, Goldberg, Jack H., additional, Rasmussen, Finn, additional, Hur, Yoon-Mi, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2015
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192. The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Honda, Chika, additional, Aaltonen, Sari, additional, Yokoyama, Yoshie, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Ning, Feng, additional, Ji, Fuling, additional, Pang, Zengchang, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Kandler, Christian, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Gatz, Margaret, additional, Butler, David A., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Hong, Changhee, additional, Chong, Youngsook, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Chang, Billy, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Aujard, Kelly, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Heikkilä, Kauko, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Jang, Kerry L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Tynelius, Per, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Ooki, Syuichi, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Inui, Fujio, additional, Watanabe, Mikio, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Rebato, Esther, additional, Martin, Nicholas G., additional, Iwatani, Yoshinori, additional, Hayakawa, Kazuo, additional, Rasmussen, Finn, additional, Sung, Joohon, additional, Harris, Jennifer R., additional, Willemsen, Gonneke, additional, Busjahn, Andreas, additional, Goldberg, Jack H., additional, Boomsma, Dorret I., additional, Hur, Yoon-Mi, additional, Sørensen, Thorkild I. A., additional, and Kaprio, Jaakko, additional

Published
2015
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194. Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together

Author

Zhou, Bin, primary, Gao, Wenjing, additional, Lv, Jun, additional, Yu, Canqing, additional, Wang, Shengfeng, additional, Liao, Chunxiao, additional, Pang, Zengchang, additional, Cong, Liming, additional, Dong, Zhong, additional, Wu, Fan, additional, Wang, Hua, additional, Wu, Xianping, additional, Jiang, Guohong, additional, Wang, Xiaojie, additional, Wang, Binyou, additional, Cao, Weihua, additional, and Li, Liming, additional

Published
2015
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195. Utilizing the Resource of Twins Reared Apart: Their Distribution Across Nine Provinces or Cities of China

Author

Gao, Wenjing, primary, Zhou, Bin, additional, Cao, Weihua, additional, Lv, Jun, additional, Yu, Canqing, additional, Wang, Shengfeng, additional, Pang, Zengchang, additional, Cong, Liming, additional, Dong, Zhong, additional, Wu, Fan, additional, Wang, Hua, additional, Wu, Xianping, additional, Jiang, Guohong, additional, Wang, Xiaojie, additional, Wang, Binyou, additional, and Li, Liming, additional

Published
2015
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197. The Genetic Basis for Cognitive Ability, Memory, and Depression Symptomatology in Middle-Aged and Elderly Chinese Twins

Author

Xu, Chunsheng, primary, Sun, Jianping, additional, Ji, Fuling, additional, Tian, Xiaocao, additional, Duan, Haiping, additional, Zhai, Yaoming, additional, Wang, Shaojie, additional, Pang, Zengchang, additional, Zhang, Dongfeng, additional, Zhao, Zhongtang, additional, Li, Shuxia, additional, Hjelmborg, Jacob v.B., additional, Christensen, Kaare, additional, and Tan, Qihua, additional

Published
2015
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199. A genome-wide association study of cognitive function in Chinese adult twins.

Author

Xu, Chunsheng, Zhang, Dongfeng, Wu, Yili, Tian, Xiaocao, Pang, Zengchang, Li, Shuxia, and Tan, Qihua

Abstract

Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions. Regression-based mixed-effect kinship model of GWAS was conducted to test the SNPs. Gene-based analysis was performed on VEGAS2. The statistically significant genes were then subject to gene set enrichment analysis to further identify the specific biological pathways associated with cognitive function. No SNPs reached genome-wide significance although there were 13 SNPs of suggestive significance ( P < 10). Gene-based analysis found 823 significant genes topped by TNRC18P1 ( P = 1.00 × 10), FGFR1OP2 ( P = 6.00 × 10), and AKR1D1 ( P = 2.30 × 10). Enrichment analysis identified 46 biological pathways, mainly involving in signaling transmission, metabolic process and Alzheimer's disease. Analysis of SNPs involved in the regulatory motif detected cell-type specific enhancers involving aorta and colon smooth muscle both have been reported to implicate in cognition. We conclude that genetic variations are significantly involved in functional genes, biological pathways and the regulatory domain that mediate cognitive performances. [ABSTRACT FROM AUTHOR]

Published
2017
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200. Fruit consumption and physical activity in relation to all-cause and cardiovascular mortality among 70,000 Chinese adults with pre-existing vascular disease.

Author

Tian, Xiaocao, Du, Huaidong, Li, Liming, Bennett, Derrick, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Guo, Yu, Bian, Zheng, Yang, Ling, Chen, Yiping, Chen, Junshi, Gao, Yan, Weng, Min, Pang, Zengchang, Jiang, Baofa, Chen, Zhengming, and null, null

Subjects
PHYSICAL activity, CARDIOVASCULAR disease related mortality, HEALTH of Chinese people, FRUIT in human nutrition, STROKE
Abstract

Objectives: To assess the associations of fresh fruit consumption and total physical activity with all-cause and cardiovascular mortality among Chinese adults who have been diagnosed with cardiovascular disease (CVD) or hypertension. Methods: During 2004–08, the China Kadoorie Biobank study recruited 70,047 adults, aged 30–79 years, with physician-diagnosed stroke or transient ischaemic attack, ischemic heart disease, or hypertension. Information on diet and physical activity was collected using an interviewer-administered electronic questionnaire. Cox regression was used to yield hazard ratios (HRs) for the independent and joint associations of fresh fruit consumption and total physical activity with mortality. Results: At baseline, 32.9% of participants consumed fresh fruit regularly (i.e. >3 days/week) and the mean total physical activity were 15.8 (SD = 11.8) MET-hr/day. During ~7-years follow-up, 6569 deaths occurred with 3563 from CVD. Compared to participants with <1 day/week fruit consumption, regular consumers had HR (95% CI) of 0.84 (0.79–0.89) for all-cause mortality and 0.79 (0.73–0.86) for CVD mortality. The HRs for the top vs bottom tertile of physical activity were 0.68 (0.64–0.72) and 0.65 (0.60–0.71), respectively, with no clear evidence of reverse causality. After correcting for regression dilution, each 100 g/day usual consumption of fresh fruit or 10 MET-hr/day usual levels of physical activity was associated with 23–29% lower mortality. The combination of regular fruit consumption with top 3rd of physical activity (>16.53 MET-hr/day) was associated with about 40% lower mortality. Conclusion: Among Chinese adults with pre-existing vascular disease, higher physical activity and fruit consumption were both independently and jointly associated with lower mortality. [ABSTRACT FROM AUTHOR]

Published
2017
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