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In bipartite networks, nodes are divided into two different sets (namely, a set of actors and a set of events), and edges exist only between actors and events. The degree sequence of bipartite graph models may contain sensitive information. Thus, it is desirable to release noisy degree sequence, not the original degree sequence, in order to decrease the risk of privacy leakage. In this article, we propose to release the degree sequence in general bipartite graphs by adding discrete Laplace noises, which satisfies differential privacy. We use the moment method to estimate the unknown model parameter. The resulted estimator satisfies differential privacy. We establish the consistency and asymptotic normality of the differentially private estimator when the number of nodes goes to infinity. Finally, we apply our theoretical results to the logistic model and the log -linear model. [ABSTRACT FROM AUTHOR]

We have identified a class of two-dimensional ferroelastic monolayers, denoted as InXY (where X = S, Se; Y = Cl, Br, I), through first-principles calculations. The dynamic, thermal, and mechanical stabilities of these InXY monolayers are validated by phonon dispersion spectra, AIMD calculations, and elastic constants, respectively. These monolayers exhibit semiconducting behavior with bandgaps ranging from 1.94 to 2.85 eV and possess excellent ferroelasticity with strong ferroelastic signals and moderate ferroelastic switching barriers. Notably, the band edge positions of InSBr and InSI monolayers are observed to stride the water redox potentials at pH = 0, indicating their potential as photocatalysts for water splitting in acidic environments. We also explored the effects of biaxial strain on the band edge alignments and photocatalytic performance of these monolayers. Moreover, the InXY monolayers exhibit excellent anisotropic optical absorption across the visible to ultraviolet regions, along with high anisotropic carrier transport. The coupling of ferroelastic and anisotropic properties in these monolayers offers promising opportunities for designing controllable electronic devices, thereby expanding their potential applications in multifunctional materials. Our findings reveal that the InXY monolayers are promising candidates for efficient photocatalytic water splitting and controllable optoelectronic applications. [ABSTRACT FROM AUTHOR]

The development of low‐cost transition metal compounds with high‐performance for efficient oxygen evolution reaction (OER) is of great significance in promoting the development of electrocatalysis. In this study, a Ce‐doped Ni3S4 catalyst (Ce0.2−Ni3S4) was synthesized through a one‐step solvothermal method, where the doped rare earth element Ce induced the transformation of NiS to Ni3S4. The Ce0.2−Ni3S4 catalyst exhibited excellent OER performance in 1 M KOH. At a current density of 10 mA cm−2, it showed a low overpotential of 230 mV and a low Tafel slope of 52.39 mV dec−1. Long‐term OER tests at the same potential lasted for 24 h without significant loss of current density. This work introduces a novel method of Ce element doping for modifying transition metal sulfides, providing new insights into the effective utilization of rare earth elements in the field of electrochemistry. It creates more chances for the progress of highly efficient catalysts for efficient OER, contributing to the advancement of electrocatalysis. [ABSTRACT FROM AUTHOR]

The wrist is a complex joint that bridges the hand to the forearm. Patients with wrist disorders increasingly prefer minimally invasive procedures for wrist joint diagnosis and treatment. Wrist arthroscopy offers direct visualization of the structures of the joint anatomy and existing disease processes while causing minimal damage to surrounding soft tissue. However, it requires a high level of technical ability for wrist arthroscopy practitioners. Therefore, an improved focus on wrist arthroscopy training combining new educational media and traditional practice should aid in the development of novel wrist arthroscopy training mode. This article aims to describe the status of wrist training and evaluation systems and introduce a new progressive wrist training system.

Abstract Background Sugarcane (Saccharum officinarum L.) is an economically important crop with stalks as the harvest organs. Improvement in stalk quality is deemed a promising strategy for enhancing sugarcane production. However, the lack of efficient approaches for systematic evaluation of sugarcane germplasm largely limits improvements in stalk quality. This study is designed to develop a systematic near-infrared spectroscopy (NIRS) assay for high-throughput phenotyping of sugarcane stalk quality, thereby providing a feasible solution for precise evaluation of sugarcane germplasm. Results A total of 628 sugarcane accessions harvested at different growth stages before and after maturity were employed to take a high-throughput assay to determine sugarcane stalk quality. Based on high-performance anion chromatography (HPAEC-PAD), large variations in sugarcane stalk quality were detected in terms of biomass composition and the corresponding fundamental ratios. Online and offline NIRS modeling strategies were applied for multiple purpose calibration with partial least square (PLS) regression analysis. Consequently, 25 equations were generated with excellent determination coefficients (R 2 ) and ratio performance deviation (RPD) values. Notably, for some observations, RPD values as high as 6.3 were observed, which indicated their exceptional performance and predictive capability. Conclusions This study provides a feasible method for consistent and high-throughput assessment of stalk quality in terms of moisture, soluble sugar, insoluble residue and the corresponding fundamental ratios. The proposed method permits large-scale screening of optimal sugarcane germplasm for sugarcane stalk quality breeding and beyond.

Abstract Anesthetic isoflurane has been reported to induce toxicity. However, the effects of isoflurane on fecundity remain largely unknown. We established a system in C. elegans to investigate the effects of isoflurane on oogenesis. Synchronized L4 stage C. elegans were treated with 7% isoflurane for 4 h. Dead cells, ROS, embryos, and unfertilized eggs laid by hermaphrodites were measured by fluorescence imaging and counting. The C. elegans with losses of ced-3, cep-1, abl-1, male C. elegans, and oxidative stress inhibitor N-acetyl-cysteine were used in the interaction studies. We found that isoflurane decreased the numbers of embryos and unfertilized eggs and increased the levels of dead cells and ROS in C. elegans. The isoflurane-induced impairment of oogenesis was associated with abl-1, ced-3, but not cep-1. N-acetyl-cysteine attenuated the isoflurane-induced impairment of oogenesis in C. elegans. Mating with male C. elegans did not attenuate the isoflurane-induced changes in oogenesis. These findings suggest that isoflurane may impair oogenesis through abl-1- and ced-3-associated, but not cep-1-associated, germ cell apoptosis and oxidative stress, pending further investigation. These studies will promote more research to determine the potential effects of anesthesia on fecundity.

With climate change and the resulting rise in temperatures, wildfire risk is increasing all over the world, particularly in the Western United States. Communities in wildland–urban interface (WUI) areas are at the greatest risk of fire. Such fires cause mass evacuations and can result in traffic congestion, endangering the lives of both citizens and first responders. While existing wildfire evacuation research focuses on social science surveys and fire spread modeling, they lack data on traffic operations during such incidents. Additionally, traditional traffic data collection methods are unable to gather large sets of data on historical wildfire events. However, the recent availability of connected vehicle (CV) data containing lane-level precision historical vehicle movement data has enabled researchers to assess traffic operational performance at the region and timeframe of interest. To address this gap, this study utilized a CV dataset to analyze traffic operations during a short-notice evacuation event caused by a wildfire, demonstrating that the CV dataset is an effective tool for accurately assessing traffic delays and overall traffic operation conditions during the selected fire incident. The findings also showed that the selected CV dataset provides high temporal coverage and similar travel time estimates as compared to an alternate method of travel time estimation. The study thus emphasized the importance of utilizing advanced technologies, such as CV data, to develop effective evacuation strategies and improve emergency management.

Clinical studies have suggested that repeated exposure to anesthesia and surgery at a young age may increase the risk of cognitive impairment. Our previous research has shown that sevoflurane can affect neurogenesis and cognitive function in young animals by altering cyclophilin D (CypD) levels and mitochondrial function. Neural progenitor cells (NPCs) migration is associated with cognitive function in developing brains. However, it is unclear whether sevoflurane can regulate NPCs migration via changes in CypD. To address this question, we treated NPCs harvested from wild-type (WT) and CypD knockout (KO) mice and young WT and CypD KO mice with sevoflurane. We used immunofluorescence staining, wound healing assay, transwell assay, mass spectrometry, and Western blot to assess the effects of sevoflurane on CypD, reactive oxygen species (ROS), doublecortin levels, and NPCs migration. We showed that sevoflurane increased levels of CypD and ROS, decreased levels of doublecortin, and reduced migration of NPCs harvested from WT mice in vitro and in WT young mice. KO of CypD attenuated these effects, suggesting that a sevoflurane-induced decrease in NPCs migration is dependent on CypD. Our findings have established a system for future studies aimed at exploring the impacts of sevoflurane anesthesia on the impairment of NPCs migration.

Abstract Background Sugarcane is one of the most crucial energy crops that produces high yields of sugar and lignocellulose. The cellulose crystallinity index (CrI) and lignin are the two kinds of key cell wall features that account for lignocellulose saccharification. Therefore, high-throughput screening of sugarcane germplasm with excellent cell wall features is considered a promising strategy to enhance bagasse digestibility. Recently, there has been research to explore near-infrared spectroscopy (NIRS) assays for the characterization of the corresponding wall features. However, due to the technical barriers of the offline strategy, it is difficult to apply for high-throughput real-time analyses. This study was therefore initiated to develop a high-throughput online NIRS assay to rapidly detect cellulose crystallinity, lignin content, and their related proportions in sugarcane, aiming to provide an efficient and feasible method for sugarcane cell wall feature evaluation. Results A total of 838 different sugarcane genotypes were collected at different growth stages during 2018 and 2019. A continuous variation distribution of the near-infrared spectrum was observed among these collections. Due to the very large diversity of CrI and lignin contents detected in the collected sugarcane samples, seven high-quality calibration models were developed through online NIRS calibration. All of the generated equations displayed coefficient of determination (R 2) values greater than 0.8 and high ratio performance deviation (RPD) values of over 2.0 in calibration, internal cross-validation, and external validation. Remarkably, the equations for CrI and total lignin content exhibited RPD values as high as 2.56 and 2.55, respectively, indicating their excellent prediction capacity. An offline NIRS assay was also performed. Comparable calibration was observed between the offline and online NIRS analyses, suggesting that both strategies would be applicable to estimate cell wall characteristics. Nevertheless, as online NIRS assays offer tremendous advantages for large-scale real-time screening applications, it could be implied that they are a better option for high-throughput cell wall feature prediction. Conclusions This study, as an initial attempt, explored an online NIRS assay for the high-throughput assessment of key cell wall features in terms of CrI, lignin content, and their proportion in sugarcane. Consistent and precise calibration results were obtained with NIRS modeling, insinuating this strategy as a reliable approach for the large-scale screening of promising sugarcane germplasm for cell wall structure improvement and beyond.

The platform of a microscopic traffic simulation provides an opportunity to study the driving behavior of vehicles on a roadway system. Compared to traditional conventional cars with human drivers, the car-following behaviors of autonomous vehicles (AVs) and connected autonomous vehicles (CAVs) would be quite different and hence require additional modeling efforts. This paper presents a thorough review of the literature on the car-following models used in prevalent micro-simulation tools for vehicles with both human and robot drivers. Specifically, the car-following logics such as the Wiedemann model and adaptive cruise control technology were reviewed based on the vehicle’s dynamic behavior and driving environments. In addition, some of the more recent “AV-ready (autonomous vehicles ready) tools” in micro-simulation platforms are also discussed in this paper.

An energy-efficient thermal control management method for space remote sensors using optical, mechanical, electrical, and thermal integration is proposed. The satellite power resources are insufficient, so an energy-efficient loop heat pipe (LHP) is designed for six intermittently operating detectors. The charge-coupled device (CCD) has a total heat generation of 72 W and operates for 8 min per orbital cycle. The LHP includes a capillary pump, six cold plates, and two radiators. The working fluid of the LHP is high-purity ammonia and the material of the wick is ceramic. The drive power on the capillary pump evaporator automatically switches between 30 W and 90 W depending on the operating mode of the remote sensor, resulting in an average power saving of about 58.2% compared to a conventional LHP. For the optical structure, a three-stage insulation technology was developed to save heater power and improve temperature stability. A transient numerical simulation model of the LHP was developed to study the vapor–liquid zone of two radiators under the condition of rapid power change. Vacuum thermal tests were conducted and the test data agreed well with the numerical simulation results. The in-orbit temperature data showed that the temperature fluctuations of the optical structure and CCD were less than ±0.2 °C and ±0.8 °C, respectively.

Candesartan is an antihypertensive agent that acts on an angiotensin II receptor. Candesartan cilexetil is a prodrug that is converted into the active form of candesartan during intestinal absorption. This study aimed to assess the pharmacokinetics and bioequivalence of a reference and a test formulation of candesartan cilexetil tablets in healthy Chinese volunteers. A randomized, open-label, single-dose, crossover study was conducted with two treatment periods. Forty-eight healthy Chinese volunteers participated under fasted conditions. Qualified subjects were randomly divided into two groups (1:1 ratio) to receive either the test or reference formulation first. A washout period of 14 days separated the administration of the two formulations. Blood samples were collected at specific time points and analyzed for candesartan concentration using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS). The maximum concentration (Cmax), the AUC from time zero to the last measured time point (AUC0-t) and the AUC from time zero to infinity (AUC0-∞) fell within the bioequivalence range of 80% to 125%. These results suggest that the test and reference formulations of candesartan cilexetil tablets are bioequivalent, meaning they have similar rates and extents of absorption in healthy Chinese volunteers. No serious adverse events or side effects were reported throughout the study. [ABSTRACT FROM AUTHOR]