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151. Focused ultrasound for the remote modulation of nitric oxide release from injectable PEG-fibrinogen hydrogels for tendon repair

Author: Kaylee M. Meyers, Alex Simon, Zerin M. Khan, Rupak M. Rajachar, and Eli Vlaisavljevich
Subjects: nitric oxide, composite hydrogels, tendon repair, focused ultrasound (FUS), stimuli-responsive, Technology
Abstract: Introduction: Tendon disorders such as tendinosis, the degradation of collagen in tendon, or tendonitis, inflammation of tendon tissue, contribute to 30% of musculoskeletal complaints. To address the limitations of currently available treatments for tendon repair, an injectable polyethylene glycol (PEG)-fibrinogen hydrogel encompassing nitric oxide (NO) releasing µ-particles was generated. The release of nitric oxide, a therapeutic molecule that modulates many wound healing processes, from the hydrogel can be modified with thermal and mechanical stimulus. To achieve remote control over NO release from hydrogels after deployment, focused ultrasound (FUS) was explored as it provides highly controlled thermal and mechanical stimulus non-invasively.Methods: In this work, the ability of FUS to remotely elicit on-demand NO generation from acoustically active composite hydrogels via thermal and/or mechanical stimulus was explored. Specifically, the temperature and time-dependent release of NO was simulated and characterized when applying FUS to composite hydrogels.Results: Results from acoustic simulations as well as thermocouple heating studies indicated that high spatial and temporal control over hydrogel warming could be achieved non-invasively with a 3.5 MHz FUS transducer. FUS was also able to remotely control NO release from hydrogels with various thermal magnitudes and durations. Additionally, no apparent changes in the mechanical properties of hydrogels were observed with FUS treatment.Discussion: Utilizing FUS thermal and mechanical stimulus provides a potential method of remotely controlling NO release from hydrogels at a wound site to aid in tendon repair.
Published: 2023
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152. Targeting dormant phenotype acquired mycobacteria using natural products by exploring its important targets: In vitro and in silico studies

Author: Shweta Sharma, Rupesh Chikhale, Nivedita Shinde, A. M. Khan, and Vivek Kumar Gupta
Subjects: tuberculosis, mycobacterium, dormancy, drug targets, phytomolecules, LTBI (latent TB infection), Microbiology, QR1-502
Abstract: The dormant phenotype of Mycobacterium tuberculosis that develops during infection poses a major challenge in disease treatment, since these bacilli show tolerance to front-line drugs. An in vitro hypoxia dormancy model was established, which produced phenotypically dormant Mycobacterium smegmatis after prolonged incubation under conditions of low oxygen, low pH, and nutrient limitation. Bacilli in this model displayed the classical dormancy characters, including loss of acid fastness, altered morphology, and, most importantly, tolerance to front-line drugs. The dormant form of M. smegmatis was treated with drugs and phytomolecules. Three phytomolecules exhibited activity against dormant bacilli, as shown by lack of regrowth in solid and liquid media. Further investigation of dormancy-active hits was carried out using in silico approaches to understand the druggable targets of these phytomolecules in dormant bacilli. For this study, molecular docking, molecular dynamics simulations (MDS), and molecular mechanics-generalized born solvent accessibility (MM-GBSA)-based binding energy (ΔGbind) calculations were performed. Five different targets, namely, isocitrate lyase (ICL), GMP synthase, LuxR, DosR, and serine/threonine protein kinase (STPK), from M. smegmatis and M. tuberculosis were studied in details. DosR and STPK were found to be the common targets in both the species that were more prone to the phytomolecules. The standard DosR inhibitor, HC104A, showed a lower dock score and binding energy of −4.27 and −34.50 kcal/mol, respectively, compared to the natural products under study. The phytomolecule, icariin, showed better docking score (dock score = −5.92 kcal/mol with and binding energy ΔGbind= −52.96 kcal/mol) with DosR compared to known DosR inhibitor, HC104A (dock score = −4.27 kcal/mol and binding energy ΔGbind = −34.50 kcal/mol). Similarly, the known STPK inhibitor MRCT67127 showed a lower dock score and binding energy of −4.25 and −29.43 kcal/mol, respectively, compared to the phytomolecule, icariin (dock score = −5.74 kcal/mol and ΔGbind= −43.41 kcal/mol). These compounds might ultimately lead to new therapeutics or may be useful as adjuvants to the first-line drugs to reduce the lengthy anti-TB therapy in the future.
Published: 2023
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153. P093 Impact of breast size on partial breast radiotherapy planning and short term outcome: a single institution experience at University Hospital of North Midlands (UHNM) UK

Author: S. Gilani, M. Batra, M. Tandon, M. Khan, A. Jegannathen, D. Gahir, S. Karanam, and M. Sivaramalingam
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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154. Application of IoT for Intelligent Home Automation System

Author: Ehatsham M. Khan, Muhammad Zahid, Tausif Zahid, Tehseen Ilahi, Ibadullah Safdar, and Iftikhar Ahmad
Subjects: Home Automation, Relay, Node-MCU (ESP32), Internet of Things (IoT), Amazon Alexa and Google Assistant, Voice Control, Smartphone., Technology
Abstract: In recent time, internet has revolutionized the whole technology. It is acting as a backbone for the information technology. Subsequently, IoT has seen considerable development as internet became more common. Similarly, research is being carried out to make IoT applications more user friendly especially in web based and android technologies. Internet of thing gives an extensive control by enabling to control remotely the switching of electronics devices such as fan, water pump, cameras, TV etc. In this paper, an IoT based home automation system for remotely controlling the home equipment’s is proposed. We are using Google Assistant and Amazon Alexa to control and monitor the electrical appliances with voice command through internet which gives more space for controlling electrical appliances. In automations, things are automatically controlled usually the basic tasks of turning ON/OFF of devices. Here we can not only turn on/off basic devices but can also regulate the speed of fan by setting it at i.e. 30%, 60 and 100%. This makes our IoT based system more intelligent to control electronic devices both from within the home and outside the home as long as internet is available. This will help to reduce the wastage of electricity and save human energy.
Published: 2023
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155. Optimization of the adsorption of lead (II) by hydroxyapatite using a factorial design: Density functional theory and molecular dynamics

Author: L. El Hammari, R. Hamed, K. Azzaoui, S. Jodeh, S. Latifi, S. Saoiabi, O. Boukra, A. Krime, A. Boukra, A. Saoiabi, B. Hammouti, M. M. Khan, R. Sabbahi, G. Hanbali, A. Berisha, M. Taleb, and O. Dagdag
Subjects: adsorption, factorial design, hydroxyapatite, lead (II), optimization, pollution, Environmental sciences, GE1-350
Abstract: Hydroxyapatite (HAp) synthesized through a wet chemical procedure was used to adsorb lead (II) from an aqueous solution. HAp was characterized using Fourier transform infrared, X-ray diffraction, Brunauer–Emmett–Teller analysis, and scanning electron microscopy. The removal of Pb+2 was investigated using the factorial design approach to investigate the efficiency of different Pb+2 concentrations, adsorption contact time, and HAp mass. The greatest Pb+2 removal (98.94%) was obtained at a starting concentration of 50 mg/L, a contact period of 15 min, and a pH of 8. At 323 K, the isothermal adoption module was fitted to the Langmuir isotherms with a regression coefficient (R2) of 0.96. The thermodynamic calculations revealed that the adsorption process was exothermic, spontaneous, and predominantly dominated by chemisorption. Furthermore, the maximum adsorption capacity (Qmax) at equilibrium was 90.18 mg/g, and the adsorption kinetics was specified by a pseudo-second-order kinetic model. Density functional theory and theoretical studies showed that the results of the experiment were correlated by the observation of a much higher negative Eads value for the lead ion adsorbate molecules as they attached to the surface of the adsorbent.
Published: 2023
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156. UK consensus definitions for necrotising otitis externa: a Delphi study

Author: Emma Stapleton, O Martin Williams, Pieter Pretorius, Monique I Andersson, Maia Patrick-Smith, Susanne H Hodgson, Maha M Khan, Pablo Martinez-Devesa, and Martin McNally
Subjects: Medicine
Abstract: Objective To establish consensus definitions for necrotising otitis externa (NOE) to facilitate the diagnosis and exclusion of NOE in clinical practice and expedite future high-quality study of this neglected condition.Design The work comprised of a systematic review of the literature, five iterative rounds of consultation via a Delphi process and open discussion within the collaborative. An expert panel analysed the results to produce the final outputs which were shared with and endorsed by national specialty bodies.Setting Secondary care in the UK.Participants UK clinical specialists practising in infection, ear nose and throat (ENT) surgery or radiology.Main outcome measures Definitions and statements meeting the following criteria were accepted: (a) minimum of 70% of respondents in agreement or strong agreement with a definition/statement AND (b)
Published: 2023
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157. Prospective study on the efficacy of endoscopic through-the-scope tack and suture system for gastric peroral endoscopic myotomy mucosal incision site closure

Author: Hafiz M. Khan, Tony S. Brar, Muhammad K. Hasan, Kambiz Kadkhodayan, Mustafa A. Arain, Maham Hayat, Aimen Farooq, Gurdeep Singh, and Dennis Yang
Subjects: Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Background and study aims Mucosal closure after gastric per-oral endoscopic myotomy (G-POEM) can be difficult due to the thick gastric mucosa. We evaluated the use of a novel through-the-scope (TTS) suture system for G-POEM mucosotomy closure. Patients and methods This was a single-center prospective study on consecutive patients who underwent G-POEM with TTS suture closure between February 2022 and August 2022. Technical success was defined as complete mucosotomy closure with TTS suture alone. On subgroup analysis, we compared performance on TTS suturing between the advanced endoscopist and the advanced endoscopy fellow (AEF) under supervision. Results Thirty-six consecutive patients (median age 60 years, interquartile range [IQR] 48.5–67], 72 % women) underwent G-POEM with TTS suture of the mucosotomy. Median mucosal incision length was 2 cm (IQR: 2–2.5). Mean mucosal closure and total procedure time were 17.5 ± 10.8 and 48.4 ± 16.8 minutes, respectively. Technical success was achieved in 24 patients (66.7 %) and 100 % of the cases were adequately closed with a combination of TTS suture and clips. When compared to the advanced endoscopist, the AEF required > 1 TTS suture system for complete closure significantly more frequently (66.7 % vs. 8.3 %, P = 0.009) and more time for mucosal closure (20.4 ± 12.1 vs. 11.9 ± 4.9 minutes, P = 0.03). Conclusions TTS suturing is effective and safe for G-POEM mucosal incision closure. With experience, technical success is high, and most closures may be achieved using a single TTS suture system alone, which has important cost and time implications. Additional comparative trials with other closure devices are need1ed.
Published: 2023
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158. Investigating charm production and fragmentation via azimuthal correlations of prompt D mesons with charged particles in pp collisions at $$\mathbf {\sqrt{ s} = 13}$$ s = 13 TeV

Author: S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, A. Bylinkin, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, R. Cruz-Torres, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, M. C. Danisch, A. Danu, I. Das, P. Das, S. Das, S. Dash, S. De, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, O. Dordic, A. K. Dubey, A. Dubla, S. Dudi, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. Q. Goh, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, M. Gorgon, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, S. Grigoryan, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, G. G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gunji, W. Guo, A. Gupta, R. Gupta, S. P. Guzman, L. Gyulai, M. K. Habib, C. Hadjidakis, G. Halimoglu, H. Hamagaki, G. Hamar, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. T. Heckel, E. Hellbär, H. Helstrup, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hofman, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, S. Hornung, A. Horzyk, R. Hosokawa, Y. Hou, P. Hristov, C. Hughes, P. Huhn, L. M. Huhta, T. J. Humanic, H. Hushnud, L. A. Husova, A. Hutson, D. Hutter, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. S. Kalteyer, A. Kalweit, V. Kaplin, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, S. D. Koryciak, A. Kotliarov, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, E. Kryshen, M. Krzewicki, V. Kučera, C. Kuhn, P. G. Kuijer, T. Kumaoka, D. Kumar, L. Kumar, N. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, A. Lakrathok, M. Lamanna, R. Langoy, K. Lapidus, P. Larionov, E. Laudi, L. Lautner, R. Lavicka, T. Lazareva, R. Lea, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, S. H. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, A. Liu, D. H. Liu, J. Liu, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, T. Mahmoud, A. Maire, M. Malaev, N. M. Malik, Q. W. Malik, L. Malinina, D. Mal’Kevich, D. Mallick, N. Mallick, P. Malzacher, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, J. Mareš, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, A. L. Mazuecos, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, J. E. Mdhluli, A. F. Mechler, F. Meddi, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, M. A. Molander, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. F. Nassirpour, A. Nath, C. Nattrass, A. Neagu, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, V. A. Okorokov, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, A. Palasciano, J. Pan, S. Panebianco, P. Pareek, J. Park, J. E. Parkkila, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, J. Porter, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, A. G. T. Ramos, T. A. Rancien, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, H. A. Reme-ness, R. Renfordt, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, T. S. Rogoschinski, D. Rohr, D. Röhrich, P. F. Rojas, S. Rojas Torres, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, A. Rossi, A. Rotondi, A. Roy, P. Roy, S. Roy, N. Rubini, O. V. Rueda, R. Rui, B. Rumyantsev, P. G. Russek, R. Russo, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. 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R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, A. Velure, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, N. Zurlo, and ALICE Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Angular correlations of heavy-flavour and charged particles in high-energy proton–proton collisions are sensitive to the production mechanisms of heavy quarks and to their fragmentation as well as hadronisation processes. The measurement of the azimuthal-correlation function of prompt D mesons with charged particles in proton–proton collisions at a centre-of-mass energy of $$\sqrt{s} = 13$$ s = 13 TeV with the ALICE detector is reported, considering $$\mathrm D^{0} $$ D 0 , $$\mathrm D^{+} $$ D + , and $$\mathrm D^{*+} $$ D ∗ + mesons in the transverse-momentum interval $$3< p_{\mathrm{T}} < 36$$ 3 < p T < 36 GeV/ $$c$$ c at midrapidity ( $$|y| < 0.5$$ | y | < 0.5 ), and charged particles with $$p_{\mathrm{T}} > 0.3$$ p T > 0.3 GeV/ $$c$$ c and pseudorapidity $$|\eta | < 0.8$$ | η | < 0.8 . This measurement has an improved precision and provides an extended transverse-momentum coverage compared to previous ALICE measurements at lower energies. The study is also performed as a function of the charged-particle multiplicity, showing no modifications of the correlation function with multiplicity within uncertainties. The properties and the transverse-momentum evolution of the near- and away-side correlation peaks are studied and compared with predictions from various Monte Carlo event generators. Among those considered, PYTHIA8 and POWHEG+PYTHIA8 provide the best description of the measured observables. The obtained results can provide guidance on tuning the generators.
Published: 2022
Full Text: View/download PDF

159. Production of light (anti)nuclei in pp collisions at $$\sqrt{s} = 5.02$$ s = 5.02 TeV

Author: S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, G. Alocco, T. Alt, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, Z. Banoo, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, P. Becht, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, A. Bylinkin, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, M. Carabas, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, I. Chakaberia, P. 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Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. F. Nassirpour, A. Nath, C. Nattrass, A. Neagu, A. Negru, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, V. A. Okorokov, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, A. Palasciano, J. Pan, S. Panebianco, J. Park, J. E. Parkkila, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, J. Porter, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, A. G. T. Ramos, T. A. Rancien, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, H. A. Reme-ness, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, T. S. Rogoschinski, D. Rohr, D. Röhrich, P. F. Rojas, S. Rojas Torres, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, A. Rossi, A. Roy, P. Roy, S. Roy, N. Rubini, O. V. Rueda, D. Ruggiano, R. Rui, B. Rumyantsev, P. G. Russek, R. Russo, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, M. P. Salvan, S. Sambyal, T. B. Saramela, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, R. Schotter, J. Schukraft, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, T. J. Shaba, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, U. Sharma, A. Shatat, O. Sheibani, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T. F. Silva, D. Silvermyr, T. Simantathammakul, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, I. Storehaug, M. M. Storetvedt, P. Stratmann, S. Strazzi, C. P. Stylianidis, A. A. P. Suaide, C. Suire, M. Sukhanov, M. Suljic, R. Sultanov, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, Z. Tang, J. D. Tapia Takaki, N. Tapus, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, G. Tersimonov, S. Thakur, D. Thomas, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, T. Tork, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, A. Uras, M. Urioni, G. L. Usai, M. Vala, N. Valle, S. Vallero, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, A. Velure, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, G. Zinovjev, N. Zurlo, and ALICE Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The study of the production of nuclei and antinuclei in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. In this paper, the production of protons, deuterons and $$^{3}\mathrm {He}$$ 3 He and their charge conjugates at midrapidity is studied as a function of the charged-particle multiplicity in inelastic pp collisions at $$\sqrt{s}=5.02$$ s = 5.02 TeV using the ALICE detector. Within the uncertainties, the yields of nuclei in pp collisions at $$\sqrt{s}=5.02$$ s = 5.02 TeV are compatible with those in pp collisions at different energies and to those in p–Pb collisions when compared at similar multiplicities. The measurements are compared with the expectations of coalescence and Statistical Hadronisation Models. The results suggest a common formation mechanism behind the production of light nuclei in hadronic interactions and confirm that they do not depend on the collision energy but on the number of produced particles.
Published: 2022
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160. Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis

Author: Tahsin M. Khan, Emily A. Verbus, Alexander J. Rossi, Jonathan M. Hernandez, Jeremy L. Davis, Brian A. Coakley, and Andrew M. Blakely
Subjects: Medicine, Science
Abstract: Abstract Wild-type KIT and PDGFRA gastrointestinal stromal tumors (GIST) are rare tumors with limited treatment options. We sought to determine the clinicopathologic features of wild-type GIST and identify factors that influence overall survival (OS) using a large national database. Retrospective evaluation of patients with wild-type GIST in the National Cancer Database (NCDB) was performed. Demographic, clinicopathologic, and treatment data were analyzed. Features associated with OS were investigated using Kaplan–Meier analysis and Cox proportional hazards model. 244 patients with median diagnosis age of 59 years (95% CI 57–63) were identified. The stomach was the most common primary site (57%) followed by the small intestine (35%). Surgical resection was performed on 85% of patients and 53% of patients received systemic therapy. Factors associated with decreased OS on multivariable analysis included small intestine primary (HR 2.72, 95% CI 1.13–6.69, P = 0.026) and > 5 mitoses per 50 HPF (HR 4.77, 95% CI 1.86–13.2, P = 0.001). Wild-type GISTs may be identified in older patients, with most arising in the stomach and small bowel. Surgery remains the principal treatment modality. Small intestine primary site and high mitotic count were associated with abbreviated OS.
Published: 2022
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161. COVID-Related Leukoencephalopathy: Unusual MRI Features and Comparability to Delayed Post Hypoxic Ischemic Encephalopathy

Author: Manzoor Ahmed, M.D, Waqar Haider Gaba, FRCP, Fahim M Khan, Rabab Al Mansoori, and Abd Al Kareem Adi
Subjects: COVID-19, Leukoencephalopathy, delayed post-hypoxic leukoencephalopathy (DPHL), Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract: COVID-19 related leukoencephalopathy can be multifactorial given the systemic effects of the viral disease. We present couple of cases with typical clinico-imaging stigmata of COVID-19 resulting in severe respiratory insufficiency. MR brain imaging revealed confluent diffuse supratentorial white matter T2 hyperintensity with restricted diffusion during the sub-acute course of the disease. The MR imaging pattern of leukoencephalopathy was non-specific but more comparable to delayed post-hypoxic leukoencephalopathy (DPHL) as also previously reported in COVID-19. Interestingly, T2 imaging showed unusual but peculiar finding of “accentuated medullary veins” in the superficial zones. No dural venous sinus thrombosis or micro-hemorrhages were present to explain “dots and stripes” due to dilated medullary veins. The patho-mechanism of this findings is not clear but may possibly be related to demyelination as DPHL has shown to be a demyelinating process. We present a review of COVID-related leukoencephalopathy with discussion on hypoxia-induced demyelinating process with accentuated medullary veins as possible associated marker.
Published: 2022
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162. Cattaneo–Christov heat flow model for copper–water nanofluid heat transfer under Marangoni convection and slip conditions

Author: Khalid Abdulkhaliq M. Alharbi, Mohammed Nasser Alshahrani, Naeem Ullah, Naseer M. Khan, Krawczuk Marek, Abd Allah A. Mousa, and Sajid Ali
Subjects: Medicine, Science
Abstract: Abstract This report is devoted to the study of the flow of MHD nanofluids through a vertical porous plate with a temperature-dependent surface tension using the Cattaneo–Christov heat flow model. The energy equation was formulated using the Cattaneo–Christov heat flux model instead of Fourier’s law of heat conduction. The Tiwari–Das model was used to take into account the concentration of nanoparticles when constructing the momentum equation. The problem is described mathematically using the boundary layer approach as a PDE, which is then converted into an ODE with the help of the transformation process. The solution finding process was completed by running the bvp4c code in MATLAB. A quantitative analysis of the influence of some newly occurring parameters on physical quantities was carried out using graphics. The addition of nanoparticles to the base fluid leads to an increase in both skin friction and thermal conductivity. The increase in thermal conductivity is the advantage, while the increase in skin friction is the disadvantage of the nanoparticle concentration. Marangoni convection has proven to be one of the most cost-effective tools available that can reduce skin friction. Marangoni convection improves the heat transfer coefficient during suction but decreases the heat transfer coefficient during the injection.
Published: 2022
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163. Prompt and non-prompt J/ψ production cross sections at midrapidity in proton-proton collisions at s $$ \sqrt{\mathrm{s}} $$ = 5.02 and 13 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, R. Cruz-Torres, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, M. C. Danisch, A. Danu, I. Das, P. Das, S. Das, S. Dash, S. De, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, S. Delsanto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, O. Dordic, A. K. Dubey, A. Dubla, S. Dudi, M. Dukhishyam, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. Q. Goh, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, M. Gorgon, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, S. Grigoryan, O. S. Groettvik, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, G. G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gunji, W. Guo, A. Gupta, R. Gupta, S. P. Guzman, L. Gyulai, M. K. Habib, C. Hadjidakis, G. Halimoglu, H. Hamagaki, G. Hamar, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. Hayashi, S. T. Heckel, E. Hellbär, H. Helstrup, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hofman, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, A. Horzyk, R. Hosokawa, Y. Hou, P. Hristov, C. Hughes, P. Huhn, T. J. Humanic, H. Hushnud, L. A. Husova, A. Hutson, D. Hutter, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, S. D. Koryciak, L. Koska, A. Kotliarov, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, E. Kryshen, M. Krzewicki, V. Kučera, C. Kuhn, P. G. Kuijer, T. Kumaoka, D. Kumar, L. Kumar, N. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, A. Lakrathok, M. Lamanna, R. Langoy, K. Lapidus, P. Larionov, E. Laudi, L. Lautner, R. Lavicka, T. Lazareva, R. Lea, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, S. H. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, A. Liu, D. H. Liu, J. Liu, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, T. Mahmoud, A. Maire, M. Malaev, N. M. Malik, Q. W. Malik, L. Malinina, D. Mal’Kevich, N. Mallick, P. Malzacher, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, J. Mareš, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, A. L. Mazuecos, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, J. E. Mdhluli, A. F. Mechler, F. Meddi, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, M. A. Molander, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. F. Nassirpour, A. Nath, C. Nattrass, A. Neagu, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, V. A. Okorokov, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, A. Palasciano, J. Pan, S. Panebianco, P. Pareek, J. Park, J. E. Parkkila, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, J. Porter, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, A. G. T. Ramos, T. A. Rancien, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, H. A. Reme-ness, R. Renfordt, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, T. S. Rogoschinski, D. Rohr, D. Röhrich, P. F. Rojas, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, A. Rossi, A. Rotondi, A. Roy, P. Roy, S. Roy, N. Rubini, O. V. Rueda, R. Rui, B. Rumyantsev, P. G. Russek, A. Rustamov, E. Ryabinkin, Y. Ryabov, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, M. P. Salvan, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, R. Schotter, J. Schukraft, Y. Schutz, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, T. J. Shaba, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, U. Sharma, O. Sheibani, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T. F. Silva, D. Silvermyr, T. Simantathammakul, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, I. Storehaug, M. M. Storetvedt, C. P. Stylianidis, A. A. P. Suaide, T. Sugitate, C. Suire, M. Sukhanov, M. Suljic, R. Sultanov, M. Šumbera, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, Z. Tang, J. D. Tapia Takaki, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, G. Tersimonov, S. Thakur, D. Thomas, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, T. Tork, S. R. Torres, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, G. Trombetta, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, B. A. Trzeciak, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, A. Uras, M. Urioni, G. L. Usai, M. Vala, N. Valle, S. Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, and N. Zurlo
Subjects: Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The production of J/ψ is measured at midrapidity (|y| < 0.9) in proton-proton collisions at s $$ \sqrt{s} $$ = 5.02 and 13 TeV, through the dielectron decay channel, using the ALICE detector at the Large Hadron Collider. The data sets used for the analyses correspond to integrated luminosities of L $$ \mathcal{L} $$ int = 19.4 ± 0.4 nb −1 and L $$ \mathcal{L} $$ int = 32.2 ± 0.5 nb −1 at s $$ \sqrt{s} $$ = 5.02 and 13 TeV, respectively. The fraction of non-prompt J/ψ mesons, i.e. those originating from the decay of beauty hadrons, is measured down to a transverse momentum p T = 2 GeV/c (1 GeV/c) at s $$ \sqrt{s} $$ = 5.02 TeV (13 TeV). The p T and rapidity (y) differential cross sections, as well as the corresponding values integrated over p T and y, are carried out separately for prompt and non-prompt J/ψ mesons. The results are compared with measurements from other experiments and theoretical calculations based on quantum chromodynamics (QCD). The shapes of the p T and y distributions of beauty quarks predicted by state-of-the-art perturbative QCD models are used to extrapolate an estimate of the b b ¯ $$ \mathrm{b}\overline{\mathrm{b}} $$ pair cross section at midrapidity and in the total phase space. The total b b ¯ $$ \mathrm{b}\overline{\mathrm{b}} $$ cross sections are found to be σ b b ¯ $$ {\sigma}_{\mathrm{b}\overline{\mathrm{b}}} $$ = 541 ± 45 (stat.) ± 69 syst . − 12 + 10 $$ {\left(\mathrm{syst}.\right)}_{-12}^{+10} $$ (extr.) μb and σ b b ¯ $$ {\sigma}_{\mathrm{b}\overline{\mathrm{b}}} $$ = 218±37 (stat.)±31 syst . − 9.1 + 8.2 $$ {\left(\mathrm{syst}.\right)}_{-9.1}^{+8.2} $$ (extr.) μb at s $$ \sqrt{s} $$ = 13 and 5.02 TeV, respectively. The value obtained from the combination of ALICE and LHCb measurements in pp collisions at s $$ \sqrt{s} $$ = 13 TeV is also provided.
Published: 2022
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164. Unpacking the legality of termination of pregnancy based on ‘social grounds’ under South African law

Author: M Khan
Subjects: Medical legislation, K3601-3611, Medicine, Medical philosophy. Medical ethics, R723-726
Abstract: The topic of abortion was in the limelight again in Dobbs v Jackson, where the US Supreme Court overturned the decision of Roe v Wade, ‘which guaranteed women and pregnant people a constitutional right to abortion’. While not bound by the judgment, this gives us an opportunity to reflect on the current law in South Africa which regulates the termination of pregnancy. The primary piece of legislation which governs abortion is the Choice on Termination of Pregnancy Act. Section 2 of the Act lists the grounds under which one may lawfully terminate a pregnancy. One of those grounds relates to the period of the 13th up until the 20th week of the gestation period, and states that if a medical practitioner, after consultation with the pregnant woman, is of the opinion that the continued pregnancy would significantly affect the social or economic circumstances of the woman, then the pregnancy may be lawfully terminated. The question is: What exactly is meant by ‘social grounds’? This article considers this aspect from a legal perspective and attempts to provide clarity on the issue, in the hope that this will be of assistance to medical practitioners who are concerned about the outcome of their actions, when assisting persons in this position.
Published: 2023
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165. Association of circulatory adiponectin with the parameters of Madras Diabetes Research Foundation-Indian Diabetes Risk Score

Author: Mohd D Khan, Mohammad K Ahmad, Roshan Alam, Saba Khan, Geeta Jaiswal, and Mohammad M Khan
Subjects: adiponectin, indian diabetes risk score, mdrf-idrs, modifiable risk factors, non-modifiable risk factors, type 2 diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Introduction: Adiponectin (APN) is an adipose-derived protein. It has shown a variety of functions such as anti-inflammatory, anti-atherogenic, antidiabetic, and insulin-sensitizing and lipid-oxidation-enhancing activities. The APN levels have shown a significant relationship with the risk factors for type 2 diabetes mellitus (T2DM). As per the Madras Diabetes Research Foundation-Indian Diabetes Risk Score (MDRF-IDRS), Asian Indians have high risk factors for T2DM and its complications. APN levels influence the risk factors for T2DM and its complications. Its circulatory level also varied with the age, family history of T2DM, waist circumference, and level of physical activity. Aim: The purpose of this narrative review is to find the association of circulatory APN with the parameters of MDRS-IDRS. Materials and Methods: Articles were searched by various databases such as PubMed, MEDLINE, Scopus, Web of Science, and Google Scholar. Abstract, free full-text, and full-text articles were searched from the year 2003 to 2022. For this review, observational study, original articles, narrative review, systematic review, and meta-analysis articles published in the English language were included. It is needed to establish the association between the APN levels and the parameters of MDRF-IDRS. The modifiable risk factors of MDRF-IDRS may play a significant role to regulate the level of APN. The non-modifiable risk factors of MDRF-IDRS may help in the better management of APN levels and reduce the prevalence of T2DM. It is needed to clear that the APN levels influence the disease severities or not. It is also needed to improve the physical activity to regulate the APN level and to reduce the systemic inflammation and insulin resistance in Asian Indian population. Conclusion: Improvement in modifiable risk factors of MDRF-IDRS and level of APN may play a significant role in the therapeutic approach to prevent and/or delay the development of T2DM and its complications.
Published: 2022
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166. A Novel Method of Clustering Using a Stochastic Approach

Author: Gabiriele Bulivou, Karuna G. Reddy, and M. G. M. Khan
Subjects: Clustering methods, dynamic programming, mathematical programming, optimum cluster partitions, statistical probability distributions, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: The cluster analysis of real-life data often encounters the challenges of noisy data or may rely heavily on the uncertainty of the main clustering variable owing to its stochastic nature, which has a potential influence on its performance. In this paper, we propose a novel clustering technique that is efficient in dealing with noise and uncertainty in a dataset by adopting a stochastic approach that uses realistic values of data points by assuming a continuous probability distribution instead of exact values. By estimating the best-fit probability distribution of the clustering variable, the proposed method formulates the problem of determining the most homogeneous clusters by determining the optimum cluster partitions (OCP) as a mathematical programming problem (MPP). A computer-intensive dynamic programming technique was used to solve the MPP and determine the OCP, which minimized the sum of the weighted intracluster standard deviations. The proposed technique is then demonstrated in this study using univariate data that follows a normal distribution, which is a symmetric distribution, as well as the Weibull distribution, which is a skewed distribution. Numerical examples were also presented to illustrate the computational details of the proposed method. Finally, using both simulated and real datasets, a comparative analysis of the effectiveness of the proposed technique was performed against four advanced clustering methods: k-means, fuzzy c-means, expectation maximization, and Genie++ hierarchical clustering. The results reveal that the proposed method works well and produces more efficient clusters than other methods.
Published: 2022
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167. Computational design and characterization of a multiepitope vaccine against carbapenemase-producing Klebsiella pneumoniae strains, derived from antigens identified through reverse vaccinology

Author: Nicola Cuscino, Ayesha Fatima, Vincenzo Di Pilato, Matteo Bulati, Caterina Alfano, Elisa Monaca, Giuseppina Di Mento, Daniele Di Carlo, Francesca Cardinale, Francesco Monaco, Gian Maria Rossolini, Asif M. Khan, Pier Giulio Conaldi, and Bruno Douradinha
Subjects: Klebsiella pneumoniae, Reverse vaccinology, Antimicrobial resistance, Carbapenems, Subunit vaccine, Bioinformatics, Biotechnology, TP248.13-248.65
Abstract: Klebsiella pneumoniae is a Gram-negative pathogen of clinical relevance, which can provoke serious urinary and blood infections and pneumonia. This bacterium is a major public health threat due to its resistance to several antibiotic classes. Using a reverse vaccinology approach, 7 potential antigens were identified, of which 4 were present in most of the sequences of Italian carbapenem-resistant K. pneumoniae clinical isolates. Bioinformatics tools demonstrated the antigenic potential of these bacterial proteins and allowed for the identification of T and B cell epitopes. This led to a rational design and in silico characterization of a multiepitope vaccine against carbapenem-resistant K. pneumoniae strains. As adjuvant, the mycobacterial heparin-binding hemagglutinin adhesin (HBHA), which is a Toll-like receptor 4 (TLR-4) agonist, was included, to increase the immunogenicity of the construct. The multiepitope vaccine candidate was analyzed by bioinformatics tools to assess its antigenicity, solubility, allergenicity, toxicity, physical and chemical parameters, and secondary and tertiary structures. Molecular docking binding energies to TLR-2 and TLR-4, two important innate immunity receptors involved in the immune response against K. pneumoniae infections, and molecular dynamics simulations of such complexes supported active interactions. A codon optimized multiepitope sequence cloning strategy is proposed, for production of recombinant vaccine in classical bacterial vectors. Finally, a 3 dose-immunization simulation with the multiepitope construct induced both cellular and humoral immune responses. These results suggest that this multiepitope construct has potential as a vaccination strategy against carbapenem-resistant K. pneumoniae and deserves further validation.
Published: 2022
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168. Toward Accountable and Explainable Artificial Intelligence Part One: Theory and Examples

Author: Masood M. Khan and Jordan Vice
Subjects: Explainable artificial intelliegence, accountable XAI, machine learning system design, interactive graphical user interface, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: Like other Artificial Intelligence (AI) systems, Machine Learning (ML) applications cannot explain decisions, are marred with training-caused biases, and suffer from algorithmic limitations. Their eXplainable Artificial Intelligence (XAI) capabilities are typically measured in a two-dimensional space of explainability and accuracy ignoring the accountability aspects. During system evaluations, measures of comprehensibility, predictive accuracy and accountability remain inseparable. We propose an Accountable eXplainable Artificial Intelligence (AXAI) capability framework for facilitating separation and measurement of predictive accuracy, comprehensibility and accountability. The proposed framework, in its current form, allows assessing embedded levels of AXAI for delineating ML systems in a three-dimensional space. The AXAI framework quantifies comprehensibility in terms of the readiness of users to apply the acquired knowledge and assesses predictive accuracy in terms of the ratio of test and training data, training data size and the number of false-positive inferences. For establishing a chain of responsibility, accountability is measured in terms of the inspectability of input cues, data being processed and the output information. We demonstrate applying the framework for assessing the AXAI capabilities of three ML systems. The reported work provides bases for building AXAI capability frameworks for other genres of AI systems.
Published: 2022
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169. Stabilization of refractive error and associated factors following small incision phacoemulsification cataract surgery

Author: Ammar M Khan, Derek M. Waldner, Micah Luong, Emi Sanders, Andrew C. S. Crichton, and Bryce A. Ford
Subjects: Ophthalmology, RE1-994
Abstract: Abstract Background Accumulating evidence suggests that refractive stabilization occurs rapidly following small incision cataract surgery. Nonetheless, many guidelines still suggest waiting four to 6 weeks before prescribing corrective lenses. This study was undertaken to supplement the existing literature regarding refractive stabilization, and evaluate multiple contributing factors that could dissuade clinicians from confidently correcting refractive error in the early post-operative course following routine cataract surgeries. Methods Adult patients undergoing phacoemulsification cataract surgery with uncomplicated surgeries and post-surgical courses at the Calgary Ophthalmology Centre (Calgary, Alberta, Canada) were included in this prospective observational case series. Exclusion criteria included known corneal dystrophies, infectious keratitis, complicated surgery or toric/multifocal IOLs. Data was collected at weekly intervals for a total of 6 weeks. Collected data included autorefraction, visual acuity, corneal pachymetry, and effective lens position. Results One hundred six eyes of 104 patients were included in this study. Post-operative sphere, cylinder and spherical equivalent were not significantly different at any post-operative week compared with week six, and 80–86% of patients were within 0.5D of last follow-up spherical equivalent at any week. The secondary outcomes of central corneal thickness, effective lens position and visual acuity did, however, exhibit significant differences between early post-operative weeks and last follow-up values. Conclusions These data suggest that refractive error can be effectively measured and corrected as early as one-week post-operatively in the majority of patients, though other measures of post-operative stability including central corneal thickness, effective lens position and visual acuity can require up to 4 weeks to stabilize. Thus a conservative and pragmatic approach may be to wait until 4 weeks post-operatively prior to obtaining refractive correction following uncomplicated phacoemulsification cataract surgery.
Published: 2022
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170. Production of light (anti)nuclei in pp collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, A. Bylinkin, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, R. Cruz-Torres, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, M. C. Danisch, A. Danu, I. Das, P. Das, S. Das, S. Dash, S. De, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, O. Dordic, A. K. Dubey, A. Dubla, S. Dudi, M. Dukhishyam, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. 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Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. S. Kalteyer, A. Kalweit, V. Kaplin, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. 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Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yasin, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, and N. Zurlo
Subjects: Hadron-Hadron scattering (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Understanding the production mechanism of light (anti)nuclei is one of the key challenges of nuclear physics and has important consequences for astrophysics, since it provides an input for indirect dark-matter searches in space. In this paper, the latest results about the production of light (anti)nuclei in pp collisions at s $$ \sqrt{s} $$ = 13 TeV are presented, focusing on the comparison with the predictions of coalescence and thermal models. For the first time, the coalescence parameters B 2 for deuterons and B 3 for helions are compared with parameter-free theoretical predictions that are directly constrained by the femtoscopic measurement of the source radius in the same event class. A fair description of the data with a Gaussian wave function is observed for both deuteron and helion, supporting the coalescence mechanism for the production of light (anti)nuclei in pp collisions. This method paves the way for future investigations of the internal structure of more complex nuclear clusters, including the hypertriton.
Published: 2022
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171. Measurement of inclusive charged-particle b-jet production in pp and p-Pb collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, G. Alocco, T. Alt, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, P. Becht, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, A. Bylinkin, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, R. Cruz-Torres, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, M. C. Danisch, A. Danu, P. Das, S. Das, S. Dash, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, A. K. Dubey, A. Dubla, S. Dudi, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. Q. Goh, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, M. Gorgon, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, S. Grigoryan, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, G. G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gunji, W. Guo, A. Gupta, R. Gupta, S. P. Guzman, L. Gyulai, M. K. Habib, C. Hadjidakis, H. Hamagaki, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. T. Heckel, E. Hellbär, H. Helstrup, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hofman, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, S. Hornung, A. Horzyk, R. Hosokawa, Y. Hou, P. Hristov, C. Hughes, P. Huhn, L. M. Huhta, C. V. Hulse, T. J. Humanic, H. Hushnud, L. A. Husova, A. Hutson, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, T. Isidori, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. S. Kalteyer, A. Kalweit, V. Kaplin, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, V. Kashyap, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, S. D. Koryciak, A. Kotliarov, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, E. Kryshen, M. Krzewicki, V. Kučera, C. Kuhn, P. G. Kuijer, T. Kumaoka, D. Kumar, L. Kumar, N. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, A. Lakrathok, M. Lamanna, R. Langoy, K. Lapidus, P. Larionov, E. Laudi, L. Lautner, R. Lavicka, T. Lazareva, R. Lea, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, S. H. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, A. Liu, D. H. Liu, J. Liu, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, T. Mahmoud, A. Maire, M. Malaev, N. M. Malik, Q. W. Malik, S. K. Malik, L. Malinina, D. Mal’Kevich, D. Mallick, N. Mallick, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, A. L. Mazuecos, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, J. E. Mdhluli, A. F. Mechler, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, M. A. Molander, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. F. Nassirpour, A. Nath, C. Nattrass, A. Neagu, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, V. A. Okorokov, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, A. Palasciano, J. Pan, S. Panebianco, J. Park, J. E. Parkkila, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, J. Porter, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, A. G. T. Ramos, T. A. Rancien, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, H. A. Reme-ness, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, T. S. Rogoschinski, D. Rohr, D. Röhrich, P. F. Rojas, S. Rojas Torres, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, A. Rossi, A. Roy, P. Roy, S. Roy, N. Rubini, O. V. Rueda, D. Ruggiano, R. Rui, B. Rumyantsev, P. G. Russek, R. Russo, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, M. P. Salvan, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, R. Schotter, J. Schukraft, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, T. J. Shaba, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, U. Sharma, O. Sheibani, A. I. Sheikh, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T. F. Silva, D. Silvermyr, T. Simantathammakul, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, I. Storehaug, M. M. Storetvedt, P. Stratmann, C. P. Stylianidis, A. A. P. Suaide, C. Suire, M. Sukhanov, M. Suljic, R. Sultanov, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, Z. Tang, J. D. Tapia Takaki, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, G. Tersimonov, S. Thakur, D. Thomas, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, T. Tork, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, A. Uras, M. Urioni, G. L. Usai, M. Vala, N. Valle, S. Vallero, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, G. Zinovjev, and N. Zurlo
Subjects: Lepton-Nucleon Scattering (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A measurement of the inclusive b-jet production cross section is presented in pp and p-Pb collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV, using data collected with the ALICE detector at the LHC. The jets were reconstructed in the central rapidity region |η| < 0.5 from charged particles using the anti-k T algorithm with resolution parameter R = 0.4. Identification of b jets exploits the long lifetime of b hadrons, using the properties of secondary vertices and impact parameter distributions. The p T-differential inclusive production cross section of b jets, as well as the corresponding inclusive b-jet fraction, are reported for pp and p-Pb collisions in the jet transverse momentum range 10 ≤ p T,ch jet ≤ 100 GeV/c, together with the nuclear modification factor, R pPb b − jet $$ {R}_{\mathrm{pPb}}^{\mathrm{b}-\mathrm{jet}} $$ . The analysis thus extends the lower p T limit of b-jet measurements at the LHC. The nuclear modification factor is found to be consistent with unity, indicating that the production of b jets in p-Pb at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV is not affected by cold nuclear matter effects within the current precision. The measurements are well reproduced by POWHEG NLO pQCD calculations with PYTHIA fragmentation.
Published: 2022
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172. Non-Oscillatory Connectivity Approach for Classification of Autism Spectrum Disorder Subtypes Using Resting-State fMRI

Author: Alishba Sadiq, Mohammed Isam Al-Hiyali, Norashikin Yahya, Tong Boon Tang, and Danish M. Khan
Subjects: Asperger’s disorder, pervasive developmental disorder, fractal free, neurodevelopmental, Pearson correlation, machine learning, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: Resting-state functional magnetic resonance imaging (rs-fMRI) is an efficient tool to measure brain connectivity and it can reveal patterns that distinguish autism spectrum disorder (ASD) from normal controls (NC). It is established that the fractal nature of neuroimaging signals will affect the estimation of brain’s functional connectivity. Therefore, the ordinary correlation of rs-fMRI may not provide the original neuronal activity of the brain. In this work, the non-oscillatory brain connectivity method is proposed to distinguish subtypes of ASD from NC. The three subtypes of ASD namely autistic disorder (ATD), Asperger’s disorder (APD), and Pervasive developmental disorder-not other specified (PDD) are classified from NC by extracting the non-oscillatory connectivity from the BOLD rs-fMRI signal. A number of significant connections are extracted by utilizing the $p$ -value analysis and these significant connections are fed to machine learning (ML) classifiers for classification of ASD subtypes against normal control. The performance for binary classification is recorded at accuracy of 98.6%, 97.2%, 97.2%, respectively, for ATD vs. NC, APD vs. NC and PDD vs. NC. Whereas, for multiclass (ATD, APD, PDD and NC), the best accuracy is 88.9%. Both binary and multiclass classification outperformed the conventional Pearson correlation-based connectivity and benchmark approaches in terms of accuracy, sensitivity, specificity. This work demonstrates the great potential of non-oscillatory connectivity approaches, not only for autism diagnosis but also for other neurological disorders.
Published: 2022
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173. Prompt D0, D+, and D*+ production in Pb–Pb collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, P. Becht, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, A. Bylinkin, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, R. Cruz-Torres, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, M. C. Danisch, A. Danu, P. Das, S. Das, S. Dash, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, A. K. Dubey, A. Dubla, S. Dudi, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. Q. Goh, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, M. Gorgon, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, S. Grigoryan, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, G. G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gunji, W. Guo, A. Gupta, R. Gupta, S. P. Guzman, L. Gyulai, M. K. Habib, C. Hadjidakis, H. Hamagaki, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. T. Heckel, E. Hellbär, H. Helstrup, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hofman, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, S. Hornung, A. Horzyk, R. Hosokawa, Y. Hou, P. Hristov, C. Hughes, P. Huhn, L. M. Huhta, C. V. Hulse, T. J. Humanic, H. Hushnud, L. A. Husova, A. Hutson, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, T. Isidori, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. S. Kalteyer, A. Kalweit, V. Kaplin, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, V. Kashyap, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, S. D. Koryciak, A. Kotliarov, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, E. Kryshen, M. Krzewicki, V. Kučera, C. Kuhn, P. G. Kuijer, T. Kumaoka, D. Kumar, L. Kumar, N. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, A. Lakrathok, M. Lamanna, R. Langoy, K. Lapidus, P. Larionov, E. Laudi, L. Lautner, R. Lavicka, T. Lazareva, R. Lea, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, S. H. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, A. Liu, D. H. Liu, J. Liu, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, T. Mahmoud, A. Maire, M. Malaev, N. M. Malik, Q. W. Malik, S. K. Malik, L. Malinina, D. Mal’Kevich, D. Mallick, N. Mallick, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, A. L. Mazuecos, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, J. E. Mdhluli, A. F. Mechler, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, M. A. Molander, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. F. Nassirpour, A. Nath, C. Nattrass, A. Neagu, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, V. A. Okorokov, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, A. Palasciano, J. Pan, S. Panebianco, J. Park, J. E. Parkkila, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, J. Porter, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, A. G. T. Ramos, T. A. Rancien, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, H. A. Reme-ness, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, T. S. Rogoschinski, D. Rohr, D. Röhrich, P. F. Rojas, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, A. Rossi, A. Roy, P. Roy, S. Roy, N. Rubini, O. V. Rueda, D. Ruggiano, R. Rui, B. Rumyantsev, P. G. Russek, R. Russo, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, M. P. Salvan, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, R. Schotter, J. Schukraft, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, T. J. Shaba, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, U. Sharma, O. Sheibani, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T. F. Silva, D. Silvermyr, T. Simantathammakul, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, I. Storehaug, M. M. Storetvedt, P. Stratmann, C. P. Stylianidis, A. A. P. Suaide, C. Suire, M. Sukhanov, M. Suljic, R. Sultanov, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, Z. Tang, J. D. Tapia Takaki, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, G. Tersimonov, S. Thakur, D. Thomas, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, T. Tork, S. R. Torres, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, A. Uras, M. Urioni, G. L. Usai, M. Vala, N. Valle, S. Vallero, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, G. Zinovjev, and N. Zurlo
Subjects: Lepton-Nucleon Scattering (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The production of prompt D0, D+, and D*+ mesons was measured at midrapidity (|y| < 0.5) in Pb–Pb collisions at the centre-of-mass energy per nucleon–nucleon pair s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decay channels and their production yields were measured in central (0–10%) and semicentral (30–50%) collisions. The measurement was performed up to a transverse momentum (p T) of 36 or 50 GeV/c depending on the D meson species and the centrality interval. For the first time in Pb–Pb collisions at the LHC, the yield of D0 mesons was measured down to p T = 0, which allowed a model-independent determination of the p T-integrated yield per unit of rapidity (dN/dy). A maximum suppression by a factor 5 and 2.5 was observed with the nuclear modification factor (R AA) of prompt D mesons at p T = 6–8 GeV/c for the 0–10% and 30–50% centrality classes, respectively. The D-meson RAA is compared with that of charged pions, charged hadrons, and J/ψ mesons as well as with theoretical predictions. The analysis of the agreement between the measured R AA, elliptic (v 2) and triangular (v 3) flow, and the model predictions allowed us to constrain the charm spatial diffusion coefficient D s . Furthermore the comparison of R AA and v 2 with different implementations of the same models provides an important insight into the role of radiative energy loss as well as charm quark recombination in the hadronisation mechanisms.
Published: 2022
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174. Wind Energy Resource Assessment for Cook Islands With Accurate Estimation of Weibull Parameters Using Frequentist and Bayesian Methods

Author: Krishneel A. Singh, M. G. M. Khan, and Mohammed Rafiuddin Ahmed
Subjects: Wind energy, Weibull distribution, wind power generation, energy resources, turbulence intensity, economic analysis, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: Wind energy resource assessments at two islands in the Cook Islands are carried out in the present work. The wind data were collected for one year from sites on Mauke and Rarotonga Islands in the Cook Islands and the daily, monthly and seasonal average wind speeds, the diurnal variations of the wind shear coefficient, average temperature and turbulence intensity were estimated. Eleven frequentist methods and a Bayesian technique were used to determine the Weibull parameters and the wind power density (WPD) for each site. The best method was determined using the goodness of fit test and error measures. The average wind speeds were 4.65 m/s and 3.86 m/s at 34 m above ground level for the sites on Mauke and Rarotonga respectively. Based on the goodness of fit tests and error measures, the Least Squares Method performed best for estimating the Weibull parameters at the Mauke site, while for the Rarotonga site, the median and quartiles method performed the best. For both the sites, the Bayesian method, which is being used for the first time for wind resource assessments, ranked second of the twelve methods, indicating good potential for this method. The annual energy production (AEP) was also determined which was calculated to be 2192.34 MWh from a total of ten Vergnet 275 kW turbines at the two sites. Finally, an economic analysis, carried out for the two sites, indicated a payback period of 7.72 years.
Published: 2022
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175. Health care services: Utilization and perception among elderly in an urban resettlement colony of Delhi

Author: Shivani Singh, Somdatta Patra, and Amir M Khan
Subjects: elderly friendly health facilities, health care, utilization, Medicine
Abstract: Context: Health care utilization informs us about the utility of services which are available. We have a paucity of studies related to health care utilization among elderly in India. Aims: The aim of this study is to find out utilization of health care services by elderly (≥60 years), pattern, factors associated with, and perception of the elderly population regarding facilitators and barriers for the same. Settings and Design: A community based cross-sectional, observational study was conducted in a resettlement colony of East Delhi. Materials and Methods: A pretested, semi-structured, and interviewer-administered questionnaire was used. Duration of data collection was November 2018 to January 2020. Statistical Analysis Used: For quantitative variables, mean, median, proportion, Chi-square test, binary logistic regression using Statistical Package for the Social Sciences (SPSS), and for qualitative variables thematic analysis were done. Results: The study included 288 study participants. Although utilization of health care services in last 15 days among elderly is 90%, it was also found that 69% of the elderly consulted a licensed medical practitioner. A private facility was visited by 58% of the study participants. Female gender (OR: 1.97; P = 0.02), religion as Hindu (OR, 2.09; P = 0.04), and marital status “single” (OR, 1.8; P = 0.04) were observed to be significant predictors of health care utilization. The participants expressed less waiting time, cashless facility for visits, availability of an accompanying person, behavior of staffs work as facilitators for utilization of services. Conclusions: Considering the unique characteristics of this age group, a shift from facility to community-based approach may be considered. Efforts may be made to create elderly friendly health facilities.
Published: 2022
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176. Enabling WiGig Communications Using Quantum-Dash Laser Source Under Smoky Weather Conditions

Author: Amr M. Ragheb, Q. Tareq, Maged. A. Esmail, Muhammad R. Alrabeiah, Saleh. A. Alshebeili, and Mohammed Z. M. Khan
Subjects: InAs/InP quantum-dash laser diode, mmWave, RoF, RoFSO, WiGig, L-band, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract: Wireless Gigabit (WiGig) is a recent wireless local area network that operates at the 60-GHz band and supports a transmission data rate of up to 20 Gbps. This paper demonstrates the generation of a V-band millimeter-wave (mmWave) signal using a new class of InAs/InP quantum-dash laser-based comb source operating in the L-band region. A 62.5-GHz mmWave signal is generated with electrical linewidth and phase noise characterization of 1 kHz and −65 dBc/Hz, respectively. Then, the transmission of the 6-Gbaud quadrature phase-shift keying (12 Gbps) signal is experimentally achieved over a hybrid radio-over-fiber (RoF) and radio-over-free-space (RoFSO) architecture comprising an 11.6-km single-mode fiber (SMF), 6-m FSO, and up to 2-m wireless link. Moreover, we also report this WiGig signal's transmission performance in terms of the measured bit error rate and error vector magnitude under various density smoke FSO channels, exhibiting a visibility range of $\sim$100 m for error-free transmission.
Published: 2022
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177. Antibiofilm and anti-quorum sensing activity of Psidium guajava L. leaf extract: In vitro and in silico approach

Author: Mo Ahamad Khan, Ismail Celik, Haris M. Khan, Mohammad Shahid, Anwar Shahzad, Sachin Kumar, and Bilal Ahmed
Subjects: Medicine, Science
Published: 2023

178. BMP9 is a potent inducer of chondrogenesis, volumetric expansion and collagen type II accumulation in bovine auricular cartilage chondroprogenitors.

Author: Oliver F W Gardner, Yadan Zhang, and Ilyas M Khan
Subjects: Medicine, Science
Abstract: Reconstruction of the outer ear currently requires harvesting of cartilage from the posterior of the auricle or ribs leading to pain and donor site morbidity. An alternative source for auricular reconstruction is in vitro tissue engineered cartilage using stem/progenitor cells. Several candidate cell-types have been studied with tissue-specific auricular cartilage progenitor cells (AuCPC) of particular interest. Whilst chondrogenic differentiation of competent stem cells using growth factor TGFβ1 produces cartilage this tissue is frequently fibrocartilaginous and lacks the morphological features of hyaline cartilage. Recent work has shown that growth factor BMP9 is a potent chondrogenic and morphogenetic factor for articular cartilage progenitor cells, and we hypothesised that this property extends to cartilage-derived progenitors from other tissues. In this study we show monoclonal populations of AuCPCs from immature and mature bovine cartilage cultured with BMP9 produced cartilage pellets have 3-5-fold greater surface area in sections than those grown with TGFβ1. Increased volumetric growth using BMP9 was due to greater sGAG deposition in immature pellets and significantly greater collagen accumulation in both immature and mature progenitor pellets. Polarised light microscopy and immunohistochemical analyses revealed that the organisation of collagen fibrils within pellets is an important factor in the growth of pellets. Additionally, chondrocytes in BMP9 stimulated cell pellets had larger lacunae and were more evenly dispersed throughout the extracellular matrix. Interestingly, BMP9 tended to normalise the response of immature AuCPC monoclonal cell lines to differentiation cues whereas cells exhibited more variation under TGFβ1. In conclusion, BMP9 appears to be a potent inducer of chondrogenesis and volumetric growth for AuCPCs a property that can be exploited for tissue engineering strategies for reconstructive surgery though with the caveat of negligible elastin production following 21-day treatment with either growth factor.
Published: 2023
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179. Infective intracardiac lesion in the setting of Mycobacterium franklinii bacteremia identified by cell-free DNA sequencing in a child with acute lymphoblastic leukemia: A potential new foe in intracardiac infections

Author: Khalifah A. Aldawsari, Evelina Dedic, Braden Olsen, Haneen Y. Abdella, Manuel R. Cotilla, and Danyal M. Khan
Subjects: Mycobacterium cheloanae-abscessus complex, Mycobacterium franklinii, Cardiac thrombus, Microbial cell-free DNA sequencing, Infectious and parasitic diseases, RC109-216
Abstract: Mycobacterium franklinii (Mfra) is a recently identified member of the Mycobacterium chelonae-abscessus complex (MCAC), a rapidly growing, acid-fast bacilli that have the potential to cause invasive human infections. Identification of Mfra is crucial for selecting the appropriate antimicrobial therapy, as Mfra displays a unique susceptibility profile compared to other MCAC members. The literature on Mfra is limited, with a few studies focusing on respiratory and skin infections. To our knowledge, we describe the first reported case of cardiac involvement associated with Mfra bacteremia in a patient with acute lymphoblastic leukemia. The isolation of Mfra through a next-generation sequencing test allowed for prompt identification and subsequent implementation of tailored antimicrobial agents, ultimately resulting in positive clinical outcomes. This case also emphasizes the significance of next-generation testing in managing immunocompromised patients with persistent fever.
Published: 2023
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180. Ranking versus rating in peer review of research grant applications.

Author: Robyn Tamblyn, Nadyne Girard, James Hanley, Bettina Habib, Adrian Mota, Karim M Khan, and Clare L Ardern
Subjects: Medicine, Science
Abstract: The allocation of public funds for research has been predominantly based on peer review where reviewers are asked to rate an application on some form of ordinal scale from poor to excellent. Poor reliability and bias of peer review rating has led funding agencies to experiment with different approaches to assess applications. In this study, we compared the reliability and potential sources of bias associated with application rating with those of application ranking in 3,156 applications to the Canadian Institutes of Health Research. Ranking was more reliable than rating and less susceptible to the characteristics of the review panel, such as level of expertise and experience, for both reliability and potential sources of bias. However, both rating and ranking penalized early career investigators and favoured older applicants. Sex bias was only evident for rating and only when the applicant's H-index was at the lower end of the H-index distribution. We conclude that when compared to rating, ranking provides a more reliable assessment of the quality of research applications, is not as influenced by reviewer expertise or experience, and is associated with fewer sources of bias. Research funding agencies should consider adopting ranking methods to improve the quality of funding decisions in health research.
Published: 2023
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181. Correction: Medication reconciliation on discharge in a tertiary care Riyadh Hospital: An observational study.

Author: Ahmed S Alanazi, Sameh Awwad, Tahir M Khan, Syed Mohammed Basheeruddin Asdaq, Yahya Mohzari, Foz Alanazi, Ahmed Alrashed, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani, and Mohammed AlMotairi
Subjects: Medicine, Science
Abstract: [This corrects the article DOI: 10.1371/journal.pone.0265042.].
Published: 2023
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182. What is the 'voltage drop' when an effective health promoting intervention for older adults-Choose to Move (Phase 3)-Is implemented at broad scale?

Author: Heather A McKay, Heather M Macdonald, Lindsay Nettlefold, Katie Weatherson, Samantha M Gray, Adrian Bauman, Karim M Khan, and Joanie Sims Gould
Subjects: Medicine, Science
Abstract: BackgroundChoose to Move (CTM), an effective health-promoting intervention for older adults, was scaled-up across British Columbia, Canada. Adaptations that enable implementation at scale may lead to 'voltage drop'-diminished positive effects of the intervention. For CTM Phase 3 we assessed: i. implementation; ii. impact on physical activity, mobility, social isolation, loneliness and health-related quality of life (impact outcomes); iii. whether intervention effects were maintained; iv) voltage drop, compared with previous CTM phases.MethodsWe conducted a type 2 hybrid effectiveness-implementation pre-post study of CTM; older adult participants (n = 1012; mean age 72.9, SD = 6.3 years; 80.6% female) were recruited by community delivery partners. We assessed CTM implementation indicators and impact outcomes via survey at 0 (baseline), 3 (mid-intervention), 6 (end-intervention) and 18 (12-month follow-up) months. We fitted mixed-effects models to describe change in impact outcomes in younger (60-74 years) and older (≥ 75 years) participants. We quantified voltage drop as percent of effect size (change from baseline to 3- and 6-months) retained in Phase 3 compared with Phases 1-2.ResultsAdaptation did not compromise fidelity of CTM Phase 3 as program components were delivered as intended. PA increased during the first 3 months in younger (+1 days/week) and older (+0.9 days/week) participants (pConclusionBenefits of health-promoting interventions-like CTM-can be retained when implemented at broad scale. Diminished social isolation in Phase 3 reflects how CTM was adapted to enhance opportunities for older adults to socially connect. Thus, although intervention effects may be reduced at scale-up, voltage drop is not inevitable.
Published: 2023
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183. Riedel’s Thyroiditis: Pitfalls in Diagnosis and Subsequent Complications

Author: R. Pandev, M. Khan, and V. Ratheesh
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Riedel’s thyroiditis is a rare disease of chronic inflammation with fibrotic infiltration of the thyroid gland and its surrounding vital structures. Due to its low incidence, there are often delays in diagnosis as it is commonly mistaken for other thyroid diseases. We report the case of a 34-year-old female patient who presented with a firm, enlarged mass in the neck, compression symptoms, and hypothyroidism. Lab tests showed elevated A-TG (thyroglobulin antibodies) and A-TPO (thyroid peroxidase antibodies) levels. Based on the disease presentation and supporting lab findings, the patient was misdiagnosed with Hashimoto’s thyroiditis and treated accordingly. Yet the patient’s symptoms grew progressively worse. She was discovered to have severe tracheal compression and bilateral RLN (recurrent laryngeal nerve) palsy. Tracheotomy became a necessary surgical intervention after the development of respiratory failure, but this procedure was complicated by the development of an intraoperative pneumothorax. After an open biopsy, histology revealed Riedel’s thyroiditis. A new treatment was introduced, with which the patient’s condition improved. However, she continued to suffer from the open tracheocutaneous fistula left by the tracheostomy, which adversely affected her everyday life. A follow-up operation was performed to close the fistula. In this case report, we discuss the consequences of misdiagnosing the patient and delaying the appropriate treatment for her disease.
Published: 2023
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184. Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

Author: Nazir M Khan, Martha Elena Diaz-Hernandez, Samir Chihab, Priyanka Priyadarshani, Pallavi Bhattaram, Luke J Mortensen, Rosa M Guzzo, and Hicham Drissi
Subjects: chondrocytes, transcriptomics, stem cells, Medicine, Science, Biology (General), QH301-705.5
Abstract: Induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine. The iPSCs exhibit a preference for lineage differentiation to the donor cell type indicating the existence of memory of origin. Although the intrinsic effect of the donor cell type on differentiation of iPSCs is well recognized, whether disease-specific factors of donor cells influence the differentiation capacity of iPSC remains unknown. Using viral based reprogramming, we demonstrated the generation of iPSCs from chondrocytes isolated from healthy (AC-iPSCs) and osteoarthritis cartilage (OA-iPSCs). These reprogrammed cells acquired markers of pluripotency and differentiated into uncommitted mesenchymal-like progenitors. Interestingly, AC-iPSCs exhibited enhanced chondrogenic potential as compared OA-iPSCs and showed increased expression of chondrogenic genes. Pan-transcriptome analysis showed that chondrocytes derived from AC-iPSCs were enriched in molecular pathways related to energy metabolism and epigenetic regulation, together with distinct expression signature that distinguishes them from OA-iPSCs. Our molecular tracing data demonstrated that dysregulation of epigenetic and metabolic factors seen in OA chondrocytes relative to healthy chondrocytes persisted following iPSC reprogramming and differentiation toward mesenchymal progenitors. Our results suggest that the epigenetic and metabolic memory of disease may predispose OA-iPSCs for their reduced chondrogenic differentiation and thus regulation at epigenetic and metabolic level may be an effective strategy for controlling the chondrogenic potential of iPSCs.
Published: 2023
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185. Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review

Author: Shahbaz M. Khan and William H. Witola
Subjects: Cryptosporidium, cryptosporidiosis, treatment, prevention, drug discovery, protozoa, Microbiology, QR1-502
Abstract: The intracellular protozoan parasite of the genus Cryptosporidium is among the leading causes of waterborne diarrheal disease outbreaks throughout the world. The parasite is transmitted by ingestion of infective oocysts that are highly stable in the environment and resistant to almost all conventional disinfection methods and water treatments. Control of the parasite infection is exceedingly difficult due to the excretion of large numbers of oocysts in the feces of infected individuals that contaminate the environment and serve as a source of infection for susceptible hosts including humans and animals. Drug development against the parasite is challenging owing to its limited genetic tractability, absence of conventional drug targets, unique intracellular location within the host, and the paucity of robust cell culture platforms for continuous parasite propagation. Despite the high prevalence of the parasite, the only US Food and Drug Administration (FDA)-approved treatment of Cryptosporidium infections is nitazoxanide, which has shown moderate efficacy in immunocompetent patients. More importantly, no effective therapeutic drugs are available for treating severe, potentially life-threatening cryptosporidiosis in immunodeficient patients, young children, and neonatal livestock. Thus, safe, inexpensive, and efficacious drugs are urgently required to reduce the ever-increasing global cryptosporidiosis burden especially in low-resource countries. Several compounds have been tested for both in vitro and in vivo efficacy against the disease. However, to date, only a few experimental compounds have been subjected to clinical trials in natural hosts, and among those none have proven efficacious. This review provides an overview of the past and present anti-Cryptosporidium pharmacotherapy in humans and agricultural animals. Herein, we also highlight the progress made in the field over the last few years and discuss the different strategies employed for discovery and development of effective prospective treatments for cryptosporidiosis.
Published: 2023
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186. Inclusive $$\text {J}/\psi $$ J / ψ production at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV

Author: S. Acharya, D. Adamová, A. Adler, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, A. Bylinkin, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, R. Cruz-Torres, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, M. C. Danisch, A. Danu, I. Das, P. Das, S. Das, S. Dash, S. De, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, S. Delsanto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, O. Dordic, A. K. Dubey, A. Dubla, S. Dudi, M. Dukhishyam, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. Q. Goh, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, M. Gorgon, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, S. Grigoryan, O. S. Groettvik, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, G. G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gunji, W. Guo, A. Gupta, R. Gupta, S. P. Guzman, L. Gyulai, M. K. Habib, C. Hadjidakis, G. Halimoglu, H. Hamagaki, G. Hamar, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. Hayashi, S. T. Heckel, E. Hellbär, H. Helstrup, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hofman, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, S. Hornung, A. Horzyk, R. Hosokawa, Y. Hou, P. Hristov, C. Hughes, P. Huhn, T. J. Humanic, H. Hushnud, L. A. Husova, A. Hutson, D. Hutter, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. S. Kalteyer, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, S. D. Koryciak, L. Koska, A. Kotliarov, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, E. Kryshen, M. Krzewicki, V. Kučera, C. Kuhn, P. G. Kuijer, T. Kumaoka, D. Kumar, L. Kumar, N. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, A. Lakrathok, M. Lamanna, R. Langoy, K. Lapidus, P. Larionov, E. Laudi, L. Lautner, R. Lavicka, T. Lazareva, R. Lea, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, S. H. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, A. Liu, D. H. Liu, J. Liu, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, T. Mahmoud, A. Maire, M. Malaev, N. M. Malik, Q. W. Malik, L. Malinina, D. Mal’Kevich, N. Mallick, P. Malzacher, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, J. Mareš, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, A. L. Mazuecos, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, J. E. Mdhluli, A. F. Mechler, F. Meddi, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, M. A. Molander, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, L. A. P. Moreno, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. F. Nassirpour, A. Nath, C. Nattrass, A. Neagu, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, V. A. Okorokov, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, A. Palasciano, J. Pan, S. Panebianco, P. Pareek, J. Park, J. E. Parkkila, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, J. Porter, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, A. G. T. Ramos, T. A. Rancien, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, H. A. Reme-ness, R. Renfordt, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, T. S. Rogoschinski, D. Rohr, D. Röhrich, P. F. Rojas, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, A. Rossi, A. Rotondi, A. Roy, P. Roy, S. Roy, N. Rubini, O. V. Rueda, R. Rui, B. Rumyantsev, P. G. Russek, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, R. Schotter, J. Schukraft, Y. Schutz, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, T. J. Shaba, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, U. Sharma, O. Sheibani, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T. F. Silva, D. Silvermyr, T. Simantathammakul, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, I. Storehaug, M. M. Storetvedt, C. P. Stylianidis, A. A. P. Suaide, T. Sugitate, C. Suire, M. Sukhanov, M. Suljic, R. Sultanov, M. Šumbera, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, Z. Tang, J. D. Tapia Takaki, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, G. Tersimonov, S. Thakur, D. Thomas, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, T. Tork, S. R. Torres, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, B. A. Trzeciak, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, A. Uras, M. Urioni, G. L. Usai, M. Vala, N. Valle, S. Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, N. Zurlo, and ALICE Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We report on the inclusive $$\text {J}/\psi $$ J / ψ production cross section measured at the CERN Large Hadron Collider in proton–proton collisions at a center-of-mass energy $$\sqrt{s}~=~13$$ s = 13 TeV. The $$\text {J}/\psi $$ J / ψ mesons are reconstructed in the $$\text {e}^{+}\text {e}^{-}$$ e + e - decay channel and the measurements are performed at midrapidity ( $$|y|
Published: 2021
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187. Women and ethnoracial minorities with poor cardiovascular health measures associated with a higher risk of developing mood disorder

Author: Aixia Guo, Kari A. Stephens, Yosef M. Khan, James R. Langabeer, and Randi E. Foraker
Subjects: Computer applications to medicine. Medical informatics, R858-859.7
Abstract: Abstract Background Mood disorders (MDS) are a type of mental health illness that effects millions of people in the United States. Early prediction of MDS can give providers greater opportunity to treat these disorders. We hypothesized that longitudinal cardiovascular health (CVH) measurements would be informative for MDS prediction. Methods To test this hypothesis, the American Heart Association’s Guideline Advantage (TGA) dataset was used, which contained longitudinal EHR from 70 outpatient clinics. The statistical analysis and machine learning models were employed to identify the associations of the MDS and the longitudinal CVH metrics and other confounding factors. Results Patients diagnosed with MDS consistently had a higher proportion of poor CVH compared to patients without MDS, with the largest difference between groups for Body mass index (BMI) and Smoking. Race and gender were associated with status of CVH metrics. Approximate 46% female patients with MDS had a poor hemoglobin A1C compared to 44% of those without MDS; 62% of those with MDS had poor BMI compared to 47% of those without MDS; 59% of those with MDS had poor blood pressure (BP) compared to 43% of those without MDS; and 43% of those with MDS were current smokers compared to 17% of those without MDS. Conclusions Women and ethnoracial minorities with poor cardiovascular health measures were associated with a higher risk of development of MDS, which indicated the high utility for using routine medical records data collected in care to improve detection and treatment for MDS among patients with poor CVH.
Published: 2021
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188. Charged-particle multiplicity fluctuations in Pb–Pb collisions at $$\sqrt{s_{\mathrm {NN}}}$$ s NN = 2.76 TeV

Author: S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, D. Berenyi, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, S. A. Bysiak, D. Caffarri, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. 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Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, W. Rzesa, O. A. M. Saarimaki, R. Sadek, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, R. Schotter, J. Schukraft, Y. Schutz, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, T. J. Shaba, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, O. Sheibani, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T. F. Silva, D. Silvermyr, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, I. Storehaug, M. M. Storetvedt, C. P. Stylianidis, A. A. P. Suaide, T. Sugitate, C. Suire, M. Suljic, R. Sultanov, M. Šumbera, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, Z. Tang, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, G. Tersimonov, S. Thakur, D. Thomas, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, T. Tork, S. R. Torres, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, G. Trombetta, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, B. A. Trzeciak, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, A. Uras, M. Urioni, G. L. Usai, M. Vala, N. Valle, S. Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, A. Zaman, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, H. Zbroszczyk, M. Zhalov, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, N. Zurlo, and ALICE Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Measurements of event-by-event fluctuations of charged-particle multiplicities in Pb–Pb collisions at $$\sqrt{s_{\mathrm {NN}}}$$ s NN $$=$$ = 2.76 TeV using the ALICE detector at the CERN Large Hadron Collider (LHC) are presented in the pseudorapidity range $$|\eta |
Published: 2021
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189. Complications of intravascular intrauterine transfusion for Rh alloimmunization

Author: Asma Alkhaibary, Mohannad Ali, Maha Tulbah, Maha Al-Nemer, Rubina M. Khan, Maisoon Al Mugbel, Nada Al Sahan, Marwah Mazen Hassounah, Waleed Alshammari, and Wesam I. Kurdi
Subjects: Medicine
Abstract: BACKGROUND: Intravascular intrauterine transfusion (IUT) is considered a safe procedure, but complications still occur, including fatalities. OBJECTIVE: Review the outcomes of Rh alloimmunization, including indications and possible complications. DESIGN: Retrospective cohort (medical record review). SETTING: Tertiary care center. PATIENTS AND METHODS: We retrieved the records for all mothers who had an IUT for Rh alloimmunization between January 2009 and August 2019. We collected data on complications, post-transfusion hemoglobin and antibody combinations. MAIN OUTCOME MEASURE: Complications of IUT. SAMPLE SIZE: 119 mothers with 154 fetuses (154 different pregnancies). RESULTS: The 154 fetuses had 560 intrauterine transfusions. The median pre-IUT hemoglobin was a median of 8.0 g/dL while the median post-IUT hemoglobin 16 g/dL. Immediate procedure-related complications included fetal bradycardia in 2.7%, significant bleeding from the cord puncture site (for more than 2 minutes in 0.9%), and contractions in 0.9%. Eight (5.2%) were delivered by cesarean delivery due to IUT-specific complications such as post-procedure fetal bradycardia. Intrauterine fetal death complicated 8.4% of the pregnancies (13 fetuses). Phototherapy was required in 76 (49.4%), postnatal blood transfusions in 17 (11%), and exchange transfusion in 11 (7.1%). Neonatal death occurred 8 (5.2%). Data were insufficient to assess associations of complications with antibody combinations. CONCLUSIONS: Intrauterine transfusion is an effective treatment with high survival rates (around 90% for cases of Rh alloimmunization). LIMITATIONS: Case series. CONFLICT OF INTEREST: None.
Published: 2021
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190. Composite of polypyrrole with sugarcane bagasse cellulosic biomass and adsorption efficiency for 2,4-dicholrophonxy acetic acid in column mode

Author: Muhammad M. Khan, Amina Khan, Haq N. Bhatti, M. Zahid, S.A. Alissa, Yaser A. El-Badry, Enas E. Hussein, and M. Iqbal
Subjects: Biocomposites, Polypyrrole, Sugarcane bagasse, 2, 4-dicholorophenoxy acetic acid, Adsorption, Column study, Mining engineering. Metallurgy, TN1-997
Abstract: The 2,4-Dicholorophenoxyacetic acid (2,4-D) is a herbicide used against broad leave herbs and it is carcinogenic and mutagenic in nature, which need to be remediated to avoid negative impact on the living organisms. In view of promising adsorption efficiency of composite materials, the present investigation is focused on the preparation of polypyrrole (PPY) and sugarcane bagasse (SB) based composites. The composites were characterized for surface properties and thermal stability. The prepared composite was utilized for the sequestration of 2,4-D from aqueous solution in column mode as function of bed height, flow rate and 2,4-D concentration. Thomas model was applied to the rate of adsorption at different 2,4-D concentrations, flow rates and bed heights to predict the breakthrough curves. The BDST (bed depth service time) model was also applied to predict the breakthrough curves as function of bed heights. The biosorption capacities of SB and PPY/SB were 6.1 and 8.63 (mg/g), respectively. The results indicated that sugarcane bagasse composite with PPY is efficient adsorbent for the remediation of 2,4-D and could have potential for the removal of herbicides from effluents.
Published: 2021
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191. Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors

Author: Andrew Coxon, Rupen Desai, Tanner M Johanns, Gavin P Dunn, Saad M Khan, Alexandra Livingstone, and Allegra Petti
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background Glioblastoma is a fatal disease despite aggressive multimodal therapy. PD-1 blockade, a therapy that reinvigorates hypofunctional exhausted CD8 T cells (Tex) in many malignancies, has not shown efficacy in glioblastoma. Loss of CD4 T cells can lead to an exhausted CD8 T-cell phenotype, and terminally exhausted CD8 T cells (Texterm) do not respond to PD-1 blockade. GL261 and CT2A are complementary orthotopic models of glioblastoma. GL261 has a functional CD4 T-cell compartment and is responsive to PD-1 blockade; notably, CD4 depletion abrogates this survival benefit. CT2A is composed of dysfunctional CD4 T cells and is PD-1 blockade unresponsive. We leverage these models to understand the impact of CD4 T cells on CD8 T-cell exhaustion and PD-1 blockade sensitivity in glioblastoma.Methods Single-cell RNA sequencing was performed on flow sorted tumor-infiltrating lymphocytes from female C57/BL6 mice implanted with each model, with and without PD-1 blockade therapy. CD8+ and CD4+ T cells were identified and separately analyzed. Survival analyses were performed comparing PD-1 blockade therapy, CD40 agonist or combinatorial therapy.Results The CD8 T-cell compartment of the models is composed of heterogenous CD8 Tex subsets, including progenitor exhausted CD8 T cells (Texprog), intermediate Tex, proliferating Tex, and Texterm. GL261 is enriched with the PD-1 responsive Texprog subset relative to the CT2A and CD4-depleted GL261 models, which are composed predominantly of the PD-1 blockade refractory Texterm subset. Analysis of the CD4 T-cell compartments revealed that the CT2A microenvironment is enriched with a suppressive Treg subset and an effector CD4 T-cell subset that expresses an inhibitory interferon-stimulated (Isc) signature. Finally, we demonstrate that addition of CD40 agonist to PD-1 blockade therapy improves survival in CT2A tumor-bearing mice.Conclusions Here, we describe that dysfunctional CD4 T cells are associated with terminal CD8 T-cell exhaustion, suggesting CD4 T cells impact PD-1 blockade efficacy by controlling the severity of exhaustion. Given that CD4 lymphopenia is frequently observed in patients with glioblastoma, this may represent a basis for resistance to PD-1 blockade. We demonstrate that CD40 agonism may circumvent a dysfunctional CD4 compartment to improve PD-1 blockade responsiveness, supporting a novel synergistic immunotherapeutic approach.
Published: 2022
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192. PHLPP1 deficiency protects against age‐related intervertebral disc degeneration

Author: Changli Zhang, Katherine M. Joseph, Nazir M. Khan, Martha Elena Diaz‐Hernandez, Hicham Drissi, and Svenja Illien‐Junger
Subjects: aging, FOXO1, intervertebral disc degeneration, matrix homeostasis, nucleus pulposus, PHLPP1, Orthopedic surgery, RD701-811
Abstract: Abstract Background Intervertebral disc (IVD) degeneration is strongly associated with low back pain and is highly prevalent in the elderly population. Hallmarks of IVD degeneration include cell loss and extracellular matrix degradation. The PH domain leucine‐rich‐repeats protein phosphatase (PHLPP1) is highly expressed in diseased cartilaginous tissues where it is linked to extracellular matrix degradation. This study explored the ability of PHLPP1 deficiency to protect against age‐related spontaneous IVD degeneration. Methods Lumbar IVDs of global Phlpp1 knockout (KO) and wildtype (WT) mice were collected at 5 months (young) and 20 months (aged). Picrosirius red–alcian blue staining (PR‐AB) was performed to examine IVD structure and histological score. The expression of aggrecan, ADAMTS5, KRT19, FOXO1 and FOXO3 was analyzed through immunohistochemistry. Cell apoptosis was assessed by TUNEL assay. Human nucleus pulposus (NP) samples were obtained from patients diagnosed with IVD degeneration. PHLPP1 knockdown in human degenerated NP cells was conducted using small interfering RNA (siRNA) transfection. The expression of PHLPP1 regulated downstream targets was analyzed via immunoblot and real time quantitative PCR. Results Histological analysis showed that Phlpp1 KO decreased the prevalence and severity of age‐related IVD degeneration. The deficiency of PHLPP1 promoted the increased expression of NP phenotypic marker KRT19, aggrecan and FOXO1, and decreased levels of ADMATS5 and cell apoptosis in the NP of aged mice. In degenerated human NP cells, PHLPP1 knockdown induced FOXO1 protein levels while FOXO1 inhibition offset the beneficial effects of PHLPP1 knockdown on KRT19 gene and protein expression. Conclusions Our findings indicate that Phlpp1 deficiency protected against NP phenotypic changes, extracellular matrix degradation, and cell apoptosis in the process of IVD degeneration, probably through FOXO1 activation, making PHLPP1 a promising therapeutic target for treating IVD degeneration.
Published: 2022
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193. Optimized Arterial Line Artifact Identification Algorithm Cleans High-Frequency Arterial Line Data With High Accuracy in Critically Ill Patients

Author: Jasmine M. Khan, BSc, David M. Maslove, MD, MSc, FRCPC, and J. Gordon Boyd, MD, PhD, FRCPC
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: OBJECTIVES:. High-frequency data streams of vital signs may be used to generate individualized hemodynamic targets for critically ill patients. Central to this precision medicine approach to resuscitation is our ability to screen these data streams for errors and artifacts. However, there is no consensus on the best method for data cleaning. Our goal was to determine whether an error-checking algorithm developed for intraoperative use could be applied to high volumes of arterial line data in an ICU population. DESIGN:. Multicenter observational study. SETTING:. ICUs across Ontario, Canada. PATIENTS:. Nested cohort of ICU patients with shock and/or respiratory failure requiring invasive mechanical ventilation. INTERVENTIONS:. High-frequency blood pressure data was analyzed. Systolic, diastolic, and mean arterial pressure minute averages were calculated. For manual analysis, a trained researcher retrospectively reviewed mean arterial pressure data, removing values that were deemed nonphysiological. The algorithm was implemented and identified artifactual data. MEASUREMENTS AND MAIN RESULTS:. Arterial line data was extracted from 15 patients. A trained researcher manually reviewed 40,798 minute-by-minute data points, then subsequently analyzed them with the algorithm. Manual review resulted in the identification of 119 artifacts (0.29%). The optimized algorithm identified 116 (97%) of these artifacts. Five hundred thirty-seven data points were erroneously removed or modified. Compared with manual review, the modified algorithm incorporating absolute thresholds of greater than 30 and less than 200 mm Hg had 97.5% sensitivity, 98.7% specificity, and a Matthew correlation coefficient of 0.41. CONCLUSIONS:. The error-checking algorithm had high sensitivity and specificity in detecting arterial line blood pressure artifacts compared with manual data cleaning. Given the growing use of large datasets and machine learning in critical care research, methods to validate the quality of high-frequency data is important to optimize algorithm performance and prevent spurious associations based on artifactual data.
Published: 2022
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194. Incidence and Predictors of Postoperative Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery

Author: Musfireh Siddiqeh, Imran Khan, Fakhar-e- Fayaz, Syed Muzaffar Hasan Kirmani, Mustafa El Hamshary, Wahidullah ., Zahid M Khan, and Rehana Javaid
Subjects: Atrial fibrillation, Coronary artery bypass grafting, Incidence, New onset, Medicine, Medicine (General), R5-920
Abstract: Objective: To study the incidence of postoperative atrial fibrillation (POAF) and its predictors after coronary artery bypass grafting (CABG) in an Asian cohort. Study Design: Cross sectional study. Place and Duration of Study: The study was conducted at the department of Cardiothoracic Surgery, Almana Hospital, Al Khobar, Saudi Arabia, which is a tertiary care hospital. The study duration was form Oct 2019 to Dec 2021. Methodology: All the male and female consecutive patients with coronary artery disease undergoing coronary artery bypass grafting (CABG) were included in the study. All the surgeries were performed through median sternotomy using cardiopulmonary bypass. Patients with emergency CABG, off pump CABG and those undergoing multiple procedures were excluded from the study. A total of 220 consecutive patients were included in the study. Patients were followed in the perioperative period. Various variables were recorded on a preformed proforma. Patients were divided into two groups, those who had atrial fibrillation (AF) and those who did not have AF. Data was analyzed using SPPS version 23 (SPSS, Inc., Chicago,IL). Results: The mean age of the patients was 51.50±11 years in the AF group and 49.38±9 years in the no AF group. The incidence of atrial fibrillation postoperatively in our cohort was (n=52, 25%). There was no statistically significant difference between the groups with respect to hypertension and diabetes (p=0.408 and p=0.054) respectively). Conclusion: In spite of a younger population, the incidence of AF in our cohort undergoing CABG is comparable to the international literature. Lack of preoperative β-blockers, statins and low ejection fraction are predictors of new onset POAF.
Published: 2022
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195. Patterns of suicide and self-harm in Pakistan: a retrospective descriptive study protocol

Author: Nargis Asad, Farhat Mirza, Murad M Khan, Shahina Pirani, Summaiya Tariq, Asra Qureshi, Mohammad Zaman, and Mustafa Aslam
Subjects: Medicine
Abstract: Introduction Suicide is a major global public health problem. Low-income and middle-income countries contribute 78% of all suicidal deaths. Pakistan, a South Asian country, lacks official statistics on suicides at national level. Statistics on suicide are neither collected nationally nor published in the annual national morbidity and mortality surveys. Medicolegal reports on suicides and self-harm are extremely rich and important source of information but greatly underused in Pakistan. We aim to examine the patterns of suicides and self-harm retrospectively in patients who were registered with medicolegal centres (MLCs) in Karachi, during the period January 2017 to December 2021.Methods and analysis Using retrospective descriptive design, the data will be collected from the medical records maintained at the main office of the Karachi police surgeon. Data from all nine MLCs of Karachi are collated and stored at the main office of Police surgeon. Information on suicide and self-harm cases will be extracted from records of all MLCs. The data will be collected using structured proforma and it will be analysed using descriptive and inferential analysis.Ethics and dissemination The study was approved for exemption from Aga Khan University, Ethical Review Committee. The findings of the study will be disseminated by conducting seminars for healthcare professionals and stakeholders including psychiatrists, psychologists, counsellors, medicolegal officers, police surgeons, mental health nurses, general and public health physicians and policy makers. Findings will be published in local and international peer-reviewed scientific journals.
Published: 2022
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196. Historical milestone in 42 years of viral sequencing—Impetus for a community-driven sequencing of global priority pathogens

Author: Li Chuin Chong and Asif M. Khan
Subjects: community, virus, SARS-CoV-2, health policy, monkeypox, sequencing, Microbiology, QR1-502
Published: 2022
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197. Lyme Disease, Anaplasmosis, and Babesiosis, Atlantic Canada

Author: Ziyad O. Allehebi, Farhan M. Khan, Mark Robbins, Elizabeth Simms, Richard Xiang, Allam Shawwa, L. Robbin Lindsay, Antonia Dibernardo, Clarice d’Entremont, Alex Crowell, Jason J. LeBlanc, and David J. Haldane
Subjects: babesiosis, babesia, Atlantic Canada, Nova Scotia, case, erythrocyte, Medicine, Infectious and parasitic diseases, RC109-216
Abstract: In July 2021, a PCR-confirmed case of locally acquired Babesia microti infection was reported in Atlantic Canada. Clinical features were consistent with babesiosis and resolved after treatment. In a region where Lyme disease and anaplasmosis are endemic, the occurrence of babesiosis emphasizes the need to enhance surveillance of tickborne infections.
Published: 2022
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198. First measurements of N-subjettiness in central Pb-Pb collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 2.76 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, D. Berenyi, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, S. A. Bysiak, D. Caffarri, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, T. G. Chavez, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, M. L. Coquet, T. M. Cormier, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, E. Cuautle, P. Cui, L. Cunqueiro, A. Dainese, F. P. A. Damas, M. C. Danisch, A. Danu, I. Das, P. Das, S. Das, S. Dash, S. De, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, L. Dello Stritto, S. Delsanto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, J. Do, A. Dobrin, B. Dönigus, O. Dordic, A. K. Dubey, A. Dubla, S. Dudi, M. Dukhishyam, P. Dupieux, N. Dzalaiova, T. M. Eder, R. J. Ehlers, V. N. Eikeland, F. Eisenhut, D. Elia, B. Erazmus, F. Ercolessi, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, A. Gautam, M. B. Gay Ducati, M. Germain, J. Ghosh, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, D. J. Q. Goh, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, M. Gorgon, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, A. Grigoryan, S. Grigoryan, O. S. Groettvik, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, G. G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gunji, A. Gupta, R. Gupta, I. B. Guzman, S. P. Guzman, L. Gyulai, M. K. Habib, C. Hadjidakis, G. Halimoglu, H. Hamagaki, G. Hamar, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. Hayashi, S. T. Heckel, E. Hellbär, H. Helstrup, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hofman, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, S. Hornung, A. Horzyk, R. Hosokawa, P. Hristov, C. Huang, C. Hughes, P. Huhn, T. J. Humanic, H. Hushnud, L. A. Husova, A. Hutson, D. 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Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, A. Zaman, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, H. Zbroszczyk, M. Zhalov, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, and N. Zurlo
Subjects: Heavy Ion Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The ALICE Collaboration reports the first fully-corrected measurements of the N-subjettiness observable for track-based jets in heavy-ion collisions. This study is performed using data recorded in pp and Pb-Pb collisions at centre-of-mass energies of s $$ \sqrt{s} $$ = 7 TeV and s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 2.76 TeV, respectively. In particular the ratio of 2-subjettiness to 1-subjettiness, τ 2 /τ 1, which is sensitive to the rate of two-pronged jet substructure, is presented. Energy loss of jets traversing the strongly interacting medium in heavy-ion collisions is expected to change the rate of two-pronged substructure relative to vacuum. The results are presented for jets with a resolution parameter of R = 0.4 and charged jet transverse momentum of 40 ≤ p T,jet ≤ 60 GeV/c, which constitute a larger jet resolution and lower jet transverse momentum interval than previous measurements in heavy-ion collisions. This has been achieved by utilising a semi-inclusive hadron-jet coincidence technique to suppress the larger jet combinatorial background in this kinematic region. No significant modification of the τ 2 /τ 1 observable for track-based jets in Pb-Pb collisions is observed relative to vacuum PYTHIA6 and PYTHIA8 references at the same collision energy. The measurements of τ 2 /τ 1, together with the splitting aperture angle ∆R, are also performed in pp collisions at s $$ \sqrt{s} $$ = 7 TeV for inclusive jets. These results are compared with PYTHIA calculations at s $$ \sqrt{s} $$ = 7 TeV, in order to validate the model as a vacuum reference for the Pb-Pb centre-of-mass energy. The PYTHIA references for τ 2 /τ 1 are shifted to larger values compared to the measurement in pp collisions. This hints at a reduction in the rate of two-pronged jets in Pb-Pb collisions compared to pp collisions.
Published: 2021
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199. Measurement of the production cross section of prompt Ξ c 0 $$ {\Xi}_{\mathrm{c}}^0 $$ baryons at midrapidity in pp collisions at s $$ \sqrt{s} $$ = 5.02 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, J. Adolfsson, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, D. Berenyi, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, S. A. Bysiak, D. Caffarri, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. 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Hushnud, L. A. Husova, A. Hutson, D. Hutter, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, M. A. Janik, T. Janson, M. Jercic, O. Jevons, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, D. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. 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Vala, N. Valle, S. Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, E. Willsher, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, A. Zaman, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, H. Zbroszczyk, M. Zhalov, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, and N. Zurlo
Subjects: Heavy Ion Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The transverse momentum (p T) differential cross section of the charm-strange baryon Ξ c 0 $$ {\Xi}_{\mathrm{c}}^0 $$ is measured at midrapidity (|y| < 0.5) via its semileptonic decay into e+Ξ − ν e in pp collisions at s $$ \sqrt{s} $$ = 5.02 TeV with the ALICE detector at the LHC. The ratio of the p T-differential Ξ c 0 $$ {\Xi}_{\mathrm{c}}^0 $$ -baryon and D0-meson production cross sections is also reported. The measurements are compared with simulations with different tunes of the PYTHIA 8 event generator, with predictions from a statistical hadronisation model (SHM) with a largely augmented set of charm-baryon states beyond the current lists of the Particle Data Group, and with models including hadronisation via quark coalescence. The p T-integrated cross section of prompt Ξ c 0 $$ {\Xi}_{\mathrm{c}}^0 $$ -baryon production at midrapidity is also reported, which is used to calculate the baryon-to-meson ratio Ξ c 0 $$ {\Xi}_{\mathrm{c}}^0 $$ /D0 = 0.20 ± 0.04 stat . − 0.07 + 0.08 $$ {\left(\mathrm{stat}.\right)}_{-0.07}^{+0.08} $$ (syst.). These results provide an additional indication of a modification of the charm fragmentation from e+e − and e − p collisions to pp collisions.
Published: 2021
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200. Anisotropic flow of identified hadrons in Xe-Xe collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.44 TeV

Author: The ALICE collaboration, S. Acharya, D. Adamová, A. Adler, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, I. Ahuja, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, F. Antinori, P. Antonioli, C. Anuj, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, L. Bergmann, M. G. Besoiu, L. Betev, P. P. Bhaduri, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, P. Bhattacharya, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, J. Biernat, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, P. M. Bond, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, Z. Buthelezi, J. B. Butt, S. A. Bysiak, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, F. D. M. Canedo, F. Carnesecchi, R. Caron, J. Castillo Castellanos, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, S. Chapeland, M. 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Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, M. Jablonski, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, A. Jalotra, M. A. Janik, T. Janson, M. Jercic, O. Jevons, A. A. P. Jimenez, F. Jonas, P. G. Jones, J. M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, C. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. P. Kitowski, J. L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. 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Maevskaya, M. Mager, T. Mahmoud, A. Maire, M. Malaev, N. M. Malik, Q. W. Malik, L. Malinina, D. Mal’Kevich, N. Mallick, P. Malzacher, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, J. Mareš, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, A. L. Mazuecos, F. Mazzaschi, M. Mazzilli, J. E. Mdhluli, A. F. Mechler, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, M. A. Molander, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, L. A. P. Moreno, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. 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V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, N. Vozniuk, J. Vrláková, B. Wagner, C. Wang, D. Wang, M. Weber, R. J. G. V. Weelden, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, W. Wu, Y. Wu, R. Xu, A. K. Yadav, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, S. Zhang, X. Zhang, Y. Zhang, V. Zherebchevskii, Y. Zhi, N. Zhigareva, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, and N. Zurlo
Subjects: Heavy Ion Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Measurements of elliptic (v 2) and triangular (v 3) flow coefficients of π ±, K±, p+ p ¯ $$ \overline{\mathrm{p}} $$ , K S 0 $$ {\mathrm{K}}_{\mathrm{S}}^0 $$ , and Λ+ Λ ¯ $$ \overline{\Lambda} $$ obtained with the scalar product method in Xe-Xe collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.44 TeV are presented. The results are obtained in the rapidity range |y| < 0.5 and reported as a function of transverse momentum, p T, for several collision centrality classes. The flow coefficients exhibit a particle mass dependence for p T < 3 GeV/c, while a grouping according to particle type (i.e., meson and baryon) is found at intermediate transverse momenta (3 < p T < 8 GeV/c). The magnitude of the baryon v 2 is larger than that of mesons up to p T = 6 GeV/c. The centrality dependence of the shape evolution of the p T-differential v 2 is studied for the various hadron species. The v 2 coefficients of π ±, K±, and p+ p ¯ $$ \overline{\mathrm{p}} $$ are reproduced by MUSIC hydrodynamic calculations coupled to a hadronic cascade model (UrQMD) for p T < 1 GeV/c. A comparison with v n measurements in the corresponding centrality intervals in Pb-Pb collisions at s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV yields an enhanced v 2 in central collisions and diminished value in semicentral collisions.
Published: 2021
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