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1,235 results on '"Ohmori, Hitoshi"'

151. Augmented humoral and anaphylactic responses in Fc(gamma)RII-deficient mice

Author

Takai, Toshiyuki, Ono, Masao, Hikida, Masaki, Ohmori, Hitoshi, and Ravetch, Jeffrey V.

Subjects
Immunoglobulin G -- Research, Anaphylaxis -- Research, Immune complexes -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Weaknesses in the low-affinity immuno-globulin-G receptor Fc(gamma)RII or its signalling pathway in B cells upset the immune-complex-mediated feedback inhibition of the generation of antibodies. A study shows that the immunoglobulin levels of mice lacking in Fc(gamma)RII soar in reaction to antigens regardless of the latter's thymus-dependence. Findings indicate that Fc(gamma)RII negatively regulates immune-complex-triggered activation in vivo for the afferent as well as the efferent limbs of the immune reaction.

Published
1996

156. Significance of Trans Fatty Acids in Cancer

Author

Ohmori, Hitoshi, Fujii, Kiyomu, and Kuniyasu, Hiroki

Subjects
linoleic acid, trans fatty acid, colorectal cancer, elaidic acid, conjugated linoleic acid
Abstract

Trans fatty acids (TFAs) are a recent focus of health problems. TFA is a definitive risk factor for cardiovascular diseases and the death. TFA is also possible risk factor for Alzheimer's disease, obesity, diabetes, fatty liver, and ovulation infertility. The relationship between TFA and carcinogenic risk is controversial; however, TFA is reported to increase the risk of breast cancer and prostate cancer. Elaidic acid (EA), a trans form of oleic acid, enhances cancer cell growth, invasion, and anti-apoptotic survival. In animal models, EA promotes tumor growth and metastasis to the lung, liver, and peritoneum. EA induces sternness in cancer cells through transactivation of EFGR via SRC from GPR40/120 as receptors in EA-integrated cholesterol rafts. Activated EGFR relays the signals to activate canonical and non-canonical wnt pathways and to inactivate notchl pathways. EA also increases miR-494, which inhibits cell differentiation through decrease of target genes. Continuous EA feeding with dosage alteration increased cancer cell sternness. EA diminishes the efficiency of 5-fluorouracil by increasing residual cancer stem cells. These findings suggest that TFA is a relevant cancer promoting factor. The decision to remove TFA from foods made by the FDA might have an impact on cancer clinics.

Published
2015

157. Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia

Author

Fujiwara-Tani, Rina, Fujii, Kiyomu, Mori, Shiori, Kishi, Shingo, Sasaki, Takamitsu, Ohmori, Hitoshi, Nakashima, Chie, Kawahara, Isao, Nishiguchi, Yukiko, Mori, Takuya, Sho, Masayuki, Kondoh, Masuo, Luo, Yi, and Kuniyasu, Hiroki

Subjects
stomatognathic system, Hippo signal, claudin-4, YAP, clostridium perfringens enterotoxin, SSA/P
Abstract

Sessile serrated adenoma/polyp with dysplasia (SSA/P-D) is an SSA/P with cellular dysplasia and has a higher risk of progressing to colon carcinogenesis. Previously, we reported that tight junction impairment by Clostridium perfringens enterotoxin (CPE) leads to activation of the transcriptional co-activator yes-associated protein (YAP) in oral squamous cell carcinoma. Here, we investigated whether CPE activates YAP to promote the malignant progression of SSA/P. E-cadherin expression was lower in the 12 cases with SSA/P-D examined than that in normal mucosa, SSA/P, or tubular adenoma (TA). Furthermore, intracellular translocation of claudin-4 (CLDN4) and nuclear translocation of YAP were observed. The CPE gene was detected in DNA extracted from SSA/P-D lesions, but not in SSA/P or TA. Treatment of the rat intestinal epithelial cell line IEC6 with low-dose CPE resulted in intracellular translocation of CLDN4 to the cytoplasmic membrane. Cytoplasmic CLDN4 showed co-precipitation with transcriptional co-activator with PDZ-binding motif, zonula occludens (ZO)-1, large tumor suppressor, and mammalian Ste20-like. Additionally, YAP co-precipitated with ZO-2 under CPE treatment led to decreased YAP phosphorylation and nuclear translocation. YAP activation promoted increase in nuclear TEA domain family member level, expression of cyclin D1, snail, vimentin, CD44, NS and decrease in E-cadherin levels, thereby inducing stemness and epithelial-mesenchymal-transition (EMT). The Hippo complex with the incorporation of CLDN4 increased stability. Upon low-dose CPE treatment, HT29 cells with BRAFᵛ⁶⁰⁰ᴱ gene mutation showed increased growth, enhanced invasive potential, stemness, and induced EMT phenotype, whereas HCT116 cells, which carry KRASᴳ¹³ᴰ gene mutation, did not show such changes. In an examination of 10 colorectal cancers, an increase in EMT and stemness was observed in CPE (+) and BRAF mutation (+) cases. These findings suggest that C. perfringens might enhance the malignant transformation of SSA/P-D via YAP activation. Our findings further highlight the importance of controlling intestinal flora using probiotics or antibiotics., 博士（医学）・甲第819号・令和4年3月15日, © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Published
2020

158. Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas

Author

Sasaki, Takamitsu, primary, Fujiwara‐Tani, Rina, additional, Kishi, Shingo, additional, Mori, Shiori, additional, Luo, Yi, additional, Ohmori, Hitoshi, additional, Kawahara, Isao, additional, Goto, Kei, additional, Nishiguchi, Yukiko, additional, Mori, Takuya, additional, Sho, Masayuki, additional, Kondo, Masuo, additional, and Kuniyasu, Hiroki, additional

Published
2019
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159. Giving combined medium‐chain fatty acids and glucose protects against cancer‐associated skeletal muscle atrophy

Author

Mori, Takuya, primary, Ohmori, Hitoshi, additional, Luo, Yi, additional, Mori, Shiori, additional, Miyagawa, Yoshihiro, additional, Nukaga, Shota, additional, Goto, Kei, additional, Fujiwara‐Tani, Rina, additional, Kishi, Shingo, additional, Sasaki, Takamitsu, additional, Fujii, Kiyomu, additional, Kawahara, Isao, additional, and Kuniyasu, Hiroki, additional

Published
2019
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161. Epitaxial growth of 3C-SiC (111) on Si via laser CVD carbonization

Author

Tu, Rong, primary, Hu, Zhiying, additional, Xu, Qingfang, additional, Li, Lin, additional, Yang, Meijun, additional, Li, Qizhong, additional, Shi, Ji, additional, Li, Haiwen, additional, Zhang, Song, additional, Zhang, Lianmeng, additional, Goto, Takashi, additional, Ohmori, Hitoshi, additional, Kosinova, Marina, additional, and Basu, Bikramjit, additional

Published
2019
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166. Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer

Author

Nishiguchi, Yukiko, primary, Fujiwara-Tani, Rina, additional, Sasaki, Takamitsu, additional, Luo, Yi, additional, Ohmori, Hitoshi, additional, Kishi, Shingo, additional, Mori, Shiori, additional, Goto, Kei, additional, Yasui, Wataru, additional, Sho, Masayuki, additional, and Kuniyasu, Hiroki, additional

Published
2019
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168. Concurrent Expression of CD47 and CD44 in Colorectal Cancer Promotes Malignancy

Author

Fujiwara-Tani, Rina, primary, Sasaki, Takamitsu, additional, Ohmori, Hitoshi, additional, Luo, Yi, additional, Goto, Kei, additional, Nishiguchi, Yukiko, additional, Mori, Shiori, additional, Nakashima, Chie, additional, Mori, Takuya, additional, Miyagawa, Yoshihiro, additional, Kawahara, Isao, additional, Fujii, Kiyomu, additional, Kishi, Shingo, additional, Tatsumoto, Naokuni, additional, and Kuniyasu, Hiroki, additional

Published
2019
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170. Morphology controlling of 〈111〉-3C–SiC films by HMDS flow rate in LCVD

Author

Xu, Qingfang, primary, Tu, Rong, additional, Sun, Qingyun, additional, Yang, Meijun, additional, Li, Qizhong, additional, Zhang, Song, additional, Zhang, Lianmeng, additional, Goto, Takashi, additional, Ohmori, Hitoshi, additional, Shi, Ji, additional, Li, Haiwen, additional, Kosinova, Marina, additional, and Bikramjit, Basu, additional

Published
2019
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171. Influence of fine bubbles on ELID grinding

Author

SAKAMOTO, Takeru, primary, ITOH, Nobuhide, additional, WATANABE, Tsubasa, additional, TAKAHASHI, Takumi, additional, OHMORI, Hitoshi, additional, KATO, Teruko, additional, and INAZAWA, Katsufumi, additional

Published
2019
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176. Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer

Author

Fujiwara-Tani, Rina, primary, Sasaki, Takamitsu, additional, Luo, Yi, additional, Goto, Kei, additional, Kawahara, Isao, additional, Nishiguchi, Yukiko, additional, Kishi, Shingo, additional, Mori, Shiori, additional, Ohmori, Hitoshi, additional, Kondoh, Masuo, additional, and Kuniyasu, Hiroki, additional

Published
2018
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184. Development of Resin Fibrous Grinding Wheels Using Twin Nozzle PELID and Analysis of Their Grinding Performance.

Author

Kashimura, Satoshi, Inazawa, Katsufumi, Ohmori, Hitoshi, and Itoh, Nobuhide

Subjects
GRINDING & polishing, REINFORCED plastics, CARBON fibers, SMART devices, EMERY-wheels
Abstract

The development of grinding wheels that are capable of improving the grinding accuracy and the finished surface roughness via the grinding process is increasingly sought in industries. The refinement of grinding wheels comprising abrasive grains is an effective means of improving the ground surface quality. The general methods used for fabricating grinding wheels tend to facilitate the aggregation of fine abrasive grains, resulting in poor abrasive distribution. Therefore, we focused on the electro-spinning mode of Patterning with Electrostatically Injected Droplet (PELID), which is capable of forming micro resin fibers. Subsequently, we attempted to fabricate fibrous grinding wheels containing abrasive grains by using the twin nozzle PELID technique that applies this mode. We confirmed through experiments that resin fibers containing abrasive grains can be manufactured efficiently using PELID and succeeded in manufacturing fibrous grinding wheels containing abrasive grains. [ABSTRACT FROM AUTHOR]

Published
2021
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191. Fast synthesis of high-quality large-area graphene by laser CVD

Author

Tu, Rong, primary, Liang, Yao, additional, Zhang, Chitengfei, additional, Li, Jun, additional, Zhang, Song, additional, Yang, Meijun, additional, Li, Qizhong, additional, Goto, Takashi, additional, Zhang, Lianmeng, additional, Shi, Ji, additional, Li, Haiwen, additional, Ohmori, Hitoshi, additional, Kosinova, Marina, additional, and Basu, Bikramjit, additional

Published
2018
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193. Epitaxial growth of 3C–SiC on Si(111) and (001) by laser CVD

Author

Zhu, Peipei, primary, Yang, Meijun, additional, Xu, Qingfang, additional, Sun, Qingyun, additional, Tu, Rong, additional, Li, Jun, additional, Zhang, Song, additional, Li, Qizhong, additional, Zhang, Lianmeng, additional, Goto, Takashi, additional, Shi, Ji, additional, Li, Haiwen, additional, Ohmori, Hitoshi, additional, Kosinova, Marina, additional, and Basu, Bikramjit, additional

Published
2018
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