523 results on '"Nygren, Jens M."'
Search Results
152. Evaluating Digital Peer Support for Children Cured from Cancer
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Lindberg, Susanne, primary, Svedberg, Petra, additional, Bergquist, Magnus, additional, and Nygren, Jens M., additional
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- 2017
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153. Girls and boys strategies to handle and cope with school-related stress
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Wilhsson, Marie, Svedberg, Petra, Högdin, Sara, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, Högdin, Sara, and Nygren, Jens M.
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Background A trend of increased stress and deteriorating mental health of adolescents is a global challenge (Currier et al, 2012). Research shows that many adolescents report high levels of stress associated with an increased focus on school performance (Moknes et al, 2014). These demands generally have a stronger impact on girl’s health (Låftman & Modig, 2013) due to context and social construction of norms, values and beliefs about femininity and masculinity (Connell, 2002; Butler, 1999). The aim was to get a deeper understanding of girls and boys perceptions of how they handle demands and school-related stress. Methods This study has an explorative design and was analyzed by qualitative content analysis described by Graneheim and Lundman (2004). The participants were 42 adolescents 15 years old, interviewed in five focus groups, dived by gender from five randomly selected schools. Two additional gender mixed focus groups with 14 adolescents 15 years old, were recruited from two of the randomly selected schools. Results The results show that girls and boys handle school-related stress by using similar strategies, but in different ways. Girls express that they have to prioritize to deselect activities they use to do to handle demands from school, and boys prioritize their own activities to obtain strength to cope with demands. Girls often think about their future while boys more often live in present time, and don’t worry so much about the future. Girls receive social support and recovery from friends and family, while boys do various activities with their friends and family to get energy. Conclusions This study shows that girls and boys used different strategies to handle demand and school-related stress. The results are based on adolescent’s experiences and could therefore be an important foundation for interventions that promote adolescents capabilities to cope with increasing demands and to handle school-related stress. Key messages: This study shows th, 9th European Public Health Conference: Parallel Sessions
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- 2016
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154. Strategies of Adolescent Girls and Boys for Coping With School-Related Stress
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Wilhsson, Marie, primary, Svedberg, Petra, additional, Högdin, Sara, additional, and Nygren, Jens M., additional
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- 2016
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155. Handling Demands of Success Among Girls and Boys in Primary School: A Conceptual Model
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Wilhsson, Marie, primary, Svedberg, Petra, additional, Carlsson, Ing-Marie, additional, Högdin, Sara, additional, and Nygren, Jens M., additional
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- 2016
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156. A Legal Framework to Support Development and Assessment of Digital Health Services
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Garell, Cecilia, primary, Svedberg, Petra, additional, and Nygren, Jens M, additional
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- 2016
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157. Promoting participation in healthcare situations for children with JIA: a grounded theory study
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Gilljam, Britt-Mari, primary, Arvidsson, Susann, additional, Nygren, Jens M., additional, and Svedberg, Petra, additional
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- 2016
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158. Patient participation, a prerequisite for care: A grounded theory study of healthcare professionals’ perceptions of what participation means in a paediatric care context.
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Carlsson, Ing‐Marie, Nygren, Jens M., and Svedberg, Petra
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- 2018
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159. 'Through my eyes': children with experience of cancer describing through photography what promotes their health
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Einberg, Eva-Lena, Nygren, Jens M., Svedberg, Petra, Enskär, Karin, Einberg, Eva-Lena, Nygren, Jens M., Svedberg, Petra, and Enskär, Karin
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- 2014
160. Self-reported objective and subjective indicators of socio-economic status and mental health between two adolescent age groups in Sweden
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Svedberg, Petra, Nygren, Jens M., Hutton, Katrin, Nyholm, Maria, Svedberg, Petra, Nygren, Jens M., Hutton, Katrin, and Nyholm, Maria
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Background: Research has shown that socio-economic status (SES) contributes to the mental health of adolescents; however the causality of this effect is debated. SES among adolescents is methodologically difficult to assess and SES indicators differ between age groups. The aim of this study was to evaluate objective and subjective indicators of SES and their relation to mental health in two adolescent age groups. Methods: This is a cross-sectional study based on data collected by self- report questionnaires from 11-13 years old n = 457 (younger age group) and 14-16 years old n = 462 (older age group) adolescents at schools in a rural town in south western Sweden. The Family Affluence Scale (FAS) (high, medium, low) and Perceived Wealth (PW) (high, medium, low) were used as measurement for objective and subjective socio-economic wealth. The domain psychological functioning health from the Minneapolis Manchester Quality of Life instrument (MMQL-PF) (continuous variable) was used to measure self-rated mental health. Results: When measuring SES using the two different scales, the proportion of adolescents in the younger age group stating a low SES was 28.1% using FAS and 12.1% using PW. In the older age group the proportion was 21.4% in FAS and 15.5% in PW. There was a positive significant relation between PW and self-rated mental health in both age groups, by 0.112 (95% CI.0.024; 0.199) in the younger age group and by 0.140 (95% CI.0.051; 0.223) in the older age group. This relation was not seen regarding FAS. Conclusion: In the search for SES’ relation to mental health, different aspects of adolescents’ socio-economic conditions should be considered. In this study we suggest that the subjective experiences of adolescents regarding the wealth of the family might be a stronger indicator of SES influencing mental health. This might be taken into consideration when planning for public health interventions and effective prevention programs suited for adolescents with lower
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- 2014
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161. Friendship Relations From the Perspective of Children With Experience of Cancer Treatment
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Einberg, Eva-Lena, primary, Svedberg, Petra, additional, Enskär, Karin, additional, and Nygren, Jens M., additional
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- 2014
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162. Self-rated mental health and socio-economic background: a study of adolescents in Sweden
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Hutton, Katrin, primary, Nyholm, Maria, additional, Nygren, Jens M, additional, and Svedberg, Petra, additional
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- 2014
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163. Psychometric evaluation of a Swedish version of Minneapolis-Manchester quality of life-youth form and adolescent form
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Einberg, Eva-Lena, Kadrija, Ibadete, Brunt, David, Nygren, Jens M., Svedberg, Petra, Einberg, Eva-Lena, Kadrija, Ibadete, Brunt, David, Nygren, Jens M., and Svedberg, Petra
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Background: It has become important to measure long-term effects and quality of life in survivors of childhood cancer. The Minneapolis- Manchester Quality of Life (MMQL) instrument has been proven to better capture the quality of life (QoL) perspective of health than other instruments. The instrument has age appropriate versions and is therefore favourable for longitudinal studies of QoL of children surviving from cancer. The aim of this study was to evaluate the psychometric properties of the Swedish version of MMQL-Youth Form and the Adolescent Form focusing on: 1) face and content validity 2) the internal consistency and 3) the test-retest reliability. Methods: The sample consisted of 950 pupils (11–16years old) from 7 schools in the western Sweden who completed the questionnaire. For the test-retest evaluation 230 respondents completed the questionnaire two weeks later. Results: Face and content validity was supported and internal consistency was found to be acceptable for the total scale for both the MMQL-Youth Form (8–12years of age) and the Adolescent Form (13–20years of age). Test-retest reliability for the MMQL-Youth Form was moderate for 50% of the items and good for the remaining. For the MMQL-Adolescent Form the test-retest showed moderate or good agreement for 80% of the items and fair for 20%. Conclusions: The result indicated that the Swedish version of the MMQLYouth Form and Adolescent Form was valid and reliable in a sample of healthy children in a Swedish context. It is recommended to test the instrument among diverse samples of children such as survivors of childhood cancer in order to validate its usefulness in research and clinical settings. © 2013 Einberg et al.; licensee BioMed Central Ltd., Funding: Ljungbergska Stiftelsen
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- 2013
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164. Building an Experience Framework for a Digital Peer Support Service for Children Surviving from Cancer
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Wärnestål, Pontus, Nygren, Jens M, Wärnestål, Pontus, and Nygren, Jens M
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Childhood cancer survivors adjust to the physical, mental, and social difficulties associated with their illness and treatment. This process can be facilitated by social support from peers. For children, this is often problematic due to geographical, clinical, and age-related limitations. This paper reports on a stakeholder assessment study that confirms the relevance of a digital peer support service for childhood cancer survivors. The analysis establishes where in the existing health care process the digital peer support service should be introduced, what actors play a key role in facilitating service onboarding and use, and characterizes desirable user experience qualities. The analysis also yields a collection of design challenges to be addressed in the development of the digital peer support service. Copyright 2013 ACM., Funding: The Swedish Research Council, the Swedish Childhood Cancer Society, the Swedish Governmental Agency for Innovation Systems (Vinnova) and the Solstickan Foundation., CHIPS
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- 2013
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165. Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging
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Norddahl, Gudmundur L, Pronk, Cornelis J, Wahlestedt, Martin, Sten, Gerd, Nygren, Jens M, Ugale, Amol, Sigvardsson, Mikael, Bryder, David, Norddahl, Gudmundur L, Pronk, Cornelis J, Wahlestedt, Martin, Sten, Gerd, Nygren, Jens M, Ugale, Amol, Sigvardsson, Mikael, and Bryder, David
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Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfunction is therefore key to understanding the aging process. Here, using a model carrying a proofreading-defective mitochondrial DNA polymerase, we demonstrate hematopoietic defects reminiscent of premature HSC aging, including anemia, lymphopenia, and myeloid lineage skewing. However, in contrast to physiological stem cell aging, rapidly accumulating mitochondria! DNA mutations had little functional effect on the hematopoietic stem cell pool, and instead caused distinct differentiation blocks and/or disappearance of downstream progenitors. These results show that intact mitochondrial function is required for appropriate multilineage stem cell differentiation, but argue against mitochondria! DNA mutations per se being a primary driver of somatic stern cell aging.
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- 2011
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166. Psychometric evaluation of a Swedish version of Minneapolis-Manchester quality of life-youth form and adolescent form
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Einberg, Eva-Lena, primary, Kadrija, Ibadete, additional, Brunt, David, additional, Nygren, Jens M, additional, and Svedberg, Petra, additional
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- 2013
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167. Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging
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Norddahl, Gudmundur L., primary, Pronk, Cornelis J., additional, Wahlestedt, Martin, additional, Sten, Gerd, additional, Nygren, Jens M., additional, Ugale, Amol, additional, Sigvardsson, Mikael, additional, and Bryder, David, additional
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- 2011
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168. A Novel Assay to Trace Proliferation History In Vivo Reveals that Enhanced Divisional Kinetics Accompany Loss of Hematopoietic Stem Cell Self-Renewal
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Nygren, Jens M., primary and Bryder, David, additional
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- 2008
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169. Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
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Nygren, Jens M., primary, Liuba, Karina, additional, Breitbach, Martin, additional, Stott, Simon, additional, Thorén, Lina, additional, Roell, Wilhelm, additional, Geisen, Caroline, additional, Sasse, Philipp, additional, Kirik, Deniz, additional, Björklund, Anders, additional, Nerlov, Claus, additional, Fleischmann, Bernd K., additional, Jovinge, Stefan, additional, and Jacobsen, Sten Eirik W., additional
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- 2008
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170. Kit Regulates Maintenance of Quiescent Hematopoietic Stem Cells
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Thorén, Lina A., primary, Liuba, Karina, additional, Bryder, David, additional, Nygren, Jens M., additional, Jensen, Christina T., additional, Qian, Hong, additional, Antonchuk, Jennifer, additional, and Jacobsen, Sten-Eirik W., additional
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- 2008
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171. Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium
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Kolossov, Eugen, primary, Bostani, Toktam, additional, Roell, Wilhelm, additional, Breitbach, Martin, additional, Pillekamp, Frank, additional, Nygren, Jens M., additional, Sasse, Philipp, additional, Rubenchik, Olga, additional, Fries, Jochen W. U., additional, Wenzel, Daniela, additional, Geisen, Caroline, additional, Xia, Ying, additional, Lu, Zhongju, additional, Duan, Yaqi, additional, Kettenhofen, Ralf, additional, Jovinge, Stefan, additional, Bloch, Wilhelm, additional, Bohlen, Heribert, additional, Welz, Armin, additional, Hescheler, Juergen, additional, Jacobsen, Sten Eirik, additional, and Fleischmann, Bernd K., additional
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- 2006
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172. Prolonged Cell Cycle Transit Is a Defining and Developmentally Conserved Hemopoietic Stem Cell Property
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Nygren, Jens M., primary, Bryder, David, additional, and Jacobsen, Sten Eirik W., additional
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- 2006
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173. Critical Role of flt3 in Fetal and Adult T Lymphopoiesis.
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Sitnicka, Ewa, primary, Buza-Vidas, Natalija, primary, Ahlenius, Henrik, primary, Cilio, Corrado M., primary, Gekas, Christos, primary, Nygren, Jens M., primary, Jensen, Christina T., primary, Svensson, Marcus, primary, Agace, William W., primary, and Jacobsen, Sten Eirik W., primary
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- 2005
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174. Adult Bone Marrow-Derived Cell Fusion with Cardiomyocytes and Purkinje Neurons in Response to Irradiation but Not in Steady State.
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Nygren, Jens M., primary, Stott, Simon, additional, Liuba, Karina, additional, Breitbach, Martin, additional, Röll, Willhelm, additional, Fleischmann, Bernd, additional, Kirik, Deniz, additional, Björklund, Anders, additional, and Jacobsen, Sten Eirik W., additional
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- 2004
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175. Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.
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Kolossov, Eugen, Bostani, Toktam, Roell, Wilhelm, Breitbach, Martin, Pillekamp, Frank, Nygren, Jens M., Sasse, Philipp, Rubenchik, Olga, Fries, Jochen W. U., Wenzel, Daniela, Geisen, Caroline, Ying Xia, Zhongju Lu, Yaqi Duan, Kettenhofen, Ralf, Jovinge, Stefan, Bloch, Wilhelm, Bohlen, Heribert, Welz, Armin, and Hescheler, Juergen
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CARDIOMYOPLASTY ,HEART failure ,BONE marrow cells ,EMBRYONIC stem cells ,MYOCARDIUM - Abstract
Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most promising cell source. Therefore, we investigated and examined the fate and functional impact of bone marrow (BM) cells and embryonic stem cell (ES cell)--derived cardiomyocytes after transplantation into the infarcted mouse heart. This proved particularly challenging for the ES cells, as their enrichment into cardiomyocytes and their long-term engraftment and tumorigenicity are still poorly understood. We generated transgenic ES cells expressing puromycin resistance and enhanced green fluorescent protein cassettes under control of a cardiac-specific promoter. Puromycin selection resulted in a highly purified (<99%) cardiomyocyte population, and the yield of cardiomyocytes increased 6-10-fold because of induction of proliferation on purification. Long-term engraftment (4-5 months) was observed when co-transplanting selected ES cell--derived cardiomyocytes and fibroblasts into the injured heart of syngeneic mice, and no teratoma formation was found (n = 60). Although transplantation of ES cell-derived cardiomyocytes improved heart function, BM cells had no positive effects. Furthermore, no contribution of BM cells to cardiac, endothelial, or smooth muscle neogenesis was detected. Hence, our results demonstrate that ES-based cell therapy is a promising approach for the treatment of impaired myocardial function and provides better results than BM-derived cells. [ABSTRACT FROM AUTHOR]
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- 2006
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176. Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate.
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Taneera J, Rosengren A, Renstrom E, Nygren JM, Serup P, Rorsman P, Jacobsen SEW, Taneera, Jalal, Rosengren, Anders, Renstrom, Erik, Nygren, Jens M, Serup, Palle, Rorsman, Patrik, and Jacobsen, Sten Eirik W
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Recent studies in normal mice have suggested that transplanted bone marrow cells can transdifferentiate into pancreatic beta-cells at relatively high efficiency. Herein, adopting the same and alternative approaches to deliver and fate map-transplanted bone marrow cells in the pancreas of normal as well as diabetic mice, we further investigated the potential of bone marrow transplantation as an alternative approach for beta-cell replacement. In contrast to previous studies, transplanted bone marrow cells expressing green fluorescence protein (GFP) under the control of the mouse insulin promoter failed to express GFP in the pancreas of normal as well as diabetic mice. Although bone marrow cells expressing GFP under the ubiquitously expressed beta-actin promoter efficiently engrafted the pancreas of normal and hyperglycemic mice, virtually all expressed CD45 and Mac-1/Gr-1, demonstrating that they adopt a hematopoietic rather than beta-cell fate, a finding further substantiated by the complete absence of GFP(+) cells expressing insulin and the beta-cell transcription factors pancreatic duodenal homeobox factor-1 and homeodomain protein. Thus, transplanted bone marrow cells demonstrated little, if any, capacity to adopt a beta-cell fate. [ABSTRACT FROM AUTHOR]
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- 2006
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177. Human CD34+hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells
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Sitnicka, Ewa, Buza-Vidas, Natalija, Larsson, Staffan, Nygren, Jens M., Liuba, Karina, and Jacobsen, Sten Erik W.
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The cytokine tyrosine kinase receptors c-kit and flt3 are expressed and function in early mouse and human hematopoiesis. Through its ability to promote ex vivo expansion and oncoretroviral transduction of primitive human hematopoietic progenitors, the flt3 ligand (FL) has emerged as a key stimulator of candidate human hematopoietic stem cells (HSCs). However, recent studies in the mouse suggest that though it is present on short-term repopulating cells, flt3 is not expressed on bone marrow long-term reconstituting HSCs, the ultimate target for the development of cell replacement and gene therapy. Herein we demonstrate that though only a fraction of human adult bone marrow and cord blood CD34+long-term culture-initiating cells (LTC-ICs) express flt3, most cord blood lymphomyeloid HSCs capable of in vivo reconstituting nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice are flt3+. The striking difference in flt3 and c-kit expression on mouse and candidate human HSCs translated into a corresponding difference in flt3 and c-kit function because FL was more efficient than SCF at supporting the survival of candidate human HSCs. In contrast, SCF is far superior to FL as a viability factor for mouse HSCs. Thus, the present data provide compelling evidence for a contrasting expression and response pattern of flt3 and c-kit on mouse and human HSCs.
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- 2003
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178. Challenges to implementing artificial intelligence in healthcare: a qualitative interview study with healthcare leaders in Sweden.
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Petersson, Lena, Larsson, Ingrid, Nygren, Jens M., Nilsen, Per, Neher, Margit, Reed, Julie E., Tyskbo, Daniel, and Svedberg, Petra
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ARTIFICIAL intelligence , *CAPACITY building , *QUALITATIVE research , *COUNTY councils , *HEALTH facilities , *MEDICAL care , *RESEARCH funding - Abstract
Background: Artificial intelligence (AI) for healthcare presents potential solutions to some of the challenges faced by health systems around the world. However, it is well established in implementation and innovation research that novel technologies are often resisted by healthcare leaders, which contributes to their slow and variable uptake. Although research on various stakeholders' perspectives on AI implementation has been undertaken, very few studies have investigated leaders' perspectives on the issue of AI implementation in healthcare. It is essential to understand the perspectives of healthcare leaders, because they have a key role in the implementation process of new technologies in healthcare. The aim of this study was to explore challenges perceived by leaders in a regional Swedish healthcare setting concerning the implementation of AI in healthcare.Methods: The study takes an explorative qualitative approach. Individual, semi-structured interviews were conducted from October 2020 to May 2021 with 26 healthcare leaders. The analysis was performed using qualitative content analysis, with an inductive approach.Results: The analysis yielded three categories, representing three types of challenge perceived to be linked with the implementation of AI in healthcare: 1) Conditions external to the healthcare system; 2) Capacity for strategic change management; 3) Transformation of healthcare professions and healthcare practice.Conclusions: In conclusion, healthcare leaders highlighted several implementation challenges in relation to AI within and beyond the healthcare system in general and their organisations in particular. The challenges comprised conditions external to the healthcare system, internal capacity for strategic change management, along with transformation of healthcare professions and healthcare practice. The results point to the need to develop implementation strategies across healthcare organisations to address challenges to AI-specific capacity building. Laws and policies are needed to regulate the design and execution of effective AI implementation strategies. There is a need to invest time and resources in implementation processes, with collaboration across healthcare, county councils, and industry partnerships. [ABSTRACT FROM AUTHOR]- Published
- 2022
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179. Lost in space - an exploration of help-seeking among young people with mental health problems: a constructivist grounded theory study.
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Westberg, Katrin Häggström, Nygren, Jens M., Nyholm, Maria, Carlsson, Ing-Marie, and Svedberg, Petra
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Background: Mental health problems among young people is a worldwide public health concern. There has been an increase in mental health problems among young people in the Nordic countries in the last 25 years, particularly in Sweden. Despite this increase, international research has repeatedly shown that young people do not access or receive support when encountering mental health problems. The purpose of this study was to explore the process of help-seeking for professional support among young people with mental health problems.Methods: The study used qualitative constructivist Grounded Theory and open-ended interviews. Thirteen young people between 15 and 23, recruited from two local support clinics, were interviewed.Results: Lost in space emerged as the core category, capturing aspects of both the experience of self and mental health problems as well as the process of seeking and acquiring help from professional support systems. The study identified several prominent barriers for seeking and acquiring professional help for mental health problems. The young people expressed a lack of knowledge on mental health issues and support services and substantial efforts were made to try to cope with problems on one's own. Lost in space involved Drifting - trying to make sense of own experiences and struggling to cope with problems, Navigating - searching for help through multiple attempts and contacts and Docking - finding support with something/somebody that feels right.Conclusions: The theoretical model sheds light on how young people with mental health problems were met with fragmented support services. Society needs to provide encompassing, youth-friendly and flexible support services, so that attempts at help-seeking are not missed. [ABSTRACT FROM AUTHOR]- Published
- 2020
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180. Impact of an Electronic Health Service on Child Participation in Pediatric Oncology Care: Quasiexperimental Study.
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Gilljam, Britt-Mari, Nygren, Jens M, Svedberg, Petra, and Arvidsson, Susann
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Background: For children 6-12 years old, there is a shortage of electronic Health (eHealth) services that promote their participation in health care. Therefore, a digital communication tool, called Sisom, was developed to give children a voice in their health care. Children with long-term diseases want to be more involved in their health care and have the right to receive information, be listened to, express their opinions, and participate in decision making in health care. However, the outcomes of using Sisom in practice at pediatric oncology clinics have not been investigated.Objective: The aim of this study was to investigate children's participation during appointments with pediatricians at pediatric oncology clinics, with or without the use of the eHealth service Sisom.Methods: A quasiexperimental design with mixed methods was used. We analyzed 27 filmed appointments with pediatricians for 14 children (8 girls and 6 boys) aged 6-12 years (mean 8.3 years) with a cancer diagnosis. The intervention group consisted of children who used Sisom prior to their appointments with pediatricians at a pediatric oncology clinic, and the control group consisted of children who had appointments with pediatricians at 4 pediatric oncology clinics. Data from observations from the videos were quantitatively and qualitatively analyzed. The quantitative analysis included manual calculations of how many times the pediatricians spoke directly to the children, the proportion of the appointment time that the children were talking, and levels of participation by the children. For the qualitative analysis, we used directed content analysis to analyze the children's levels of participation guided by a framework based on Shier's model of participation.Results: Pediatricians directed a greater proportion of their discussion toward the child in the intervention group (731 occasions) than in the control group (624 occasions), but the proportion of the appointment time the children talked was almost the same for both the intervention and control groups (mean 17.0 minutes vs 17.6 minutes). The levels of participation corresponded to the first three levels of Shier's participation model: children were listened to, children were supported to express their views, and children's views were taken into account. The results showed an increased level of participation by the children in the intervention group. Several codes that were found did not fit into any of the existing categories, and a new category was thus formed: children received information.Conclusions: This study shows that the eHealth service Sisom can increase children's participation during appointments with health care professionals. Further studies employing a randomized control design focusing on the effects of eHealth services on children's health outcomes, perceived participation, and cost-effectiveness could make a significant contribution to guiding the implementation of eHealth services in pediatric care. [ABSTRACT FROM AUTHOR]- Published
- 2020
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181. Creating a shielding place for children with leukaemia during sedation for intrathecal chemotherapy: A grounded theory study.
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Sjöberg, Carina, Carlsson, Ing-Marie, Källstrand, Jeanette, Svedberg, Petra, and Nygren, Jens M.
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Childhood cancer invades the child's daily life and has a strong influence on their living conditions and lifestyle. The treatment is an unpleasant experience and the children often perceive the treatment as worse than the actual disease. The aim of the present study was thus to explore the process of how healthcare professionals improved care for children undergoing sedation for intrathecal chemotherapy. A constructivist grounded theory approach was applied and qualitative interviews with paediatricians (n = 2), anaesthetists (n = 2), paediatric nurses (n = 3) and nurse anaesthetists (n = 5). The theory of creating a shielding place emerged and conceptualized the pattern of behavior of healthcare professionals throughout the procedure of sedation for intrathecal chemotherapy for pediatric leukaemia. The theory explains the core category 'shielding' and the process of how healthcare professionals developed strategies to resolve their main concern: a striving to reduce discomfort and suffering induced by the procedure and the treatment. These strategies, used throughout the procedure, were; de-dramatizing, de-exposing and minimizing trespassing. The theory of creating a shielding place offers a greater understanding of how healthcare professionals included the child's perspective in their work and thereby enabled a more sensitive and supportive care that had an impact on both quality of care and patient safety. The results from the study contributes with theoretical knowledge that can be used for developing evidence-based care guidelines for the procedure of sedating a child with leukaemia for intrathecal chemotherapy. • The study shows how healthcare professionals include the child's perspective during sedation for intrathecal chemotherapy. • The results from the study contribute with theoretical knowledge, from a multi-professional perspective. • The result highlights the importance of the setting for implementing a more child-centred perspective. • The child-centred perspective entails impact on both quality of care and patient safety, during the procedure. [ABSTRACT FROM AUTHOR]
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- 2020
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182. A comprehensive overview of barriers and strategies for AI implementation in healthcare: Mixed-method design.
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Nair, Monika, Svedberg, Petra, Larsson, Ingrid, and Nygren, Jens M.
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LITERATURE reviews , *MEDICAL personnel , *ETHICAL problems , *ARTIFICIAL intelligence , *CHANGE management - Abstract
Implementation of artificial intelligence systems for healthcare is challenging. Understanding the barriers and implementation strategies can impact their adoption and allows for better anticipation and planning. This study's objective was to create a detailed inventory of barriers to and strategies for AI implementation in healthcare to support advancements in methods and implementation processes in healthcare. A sequential explanatory mixed method design was used. Firstly, scoping reviews and systematic literature reviews were identified using PubMed. Selected studies included empirical cases of AI implementation and use in clinical practice. As the reviews were deemed insufficient to fulfil the aim of the study, data collection shifted to the primary studies included in those reviews. The primary studies were screened by title and abstract, and thereafter read in full text. Then, data on barriers to and strategies for AI implementation were extracted from the included articles, thematically coded by inductive analysis, and summarized. Subsequently, a direct qualitative content analysis of 69 interviews with healthcare leaders and healthcare professionals confirmed and added results from the literature review. Thirty-eight empirical cases from the six identified scoping and literature reviews met the inclusion and exclusion criteria. Barriers to and strategies for AI implementation were grouped under three phases of implementation (planning, implementing, and sustaining the use) and were categorized into eleven concepts; Leadership, Buy-in, Change management, Engagement, Workflow, Finance and human resources, Legal, Training, Data, Evaluation and monitoring, Maintenance. Ethics emerged as a twelfth concept through qualitative analysis of the interviews. This study illustrates the inherent challenges and useful strategies in implementing AI in healthcare practice. Future research should explore various aspects of leadership, collaboration and contracts among key stakeholders, legal strategies surrounding clinicians' liability, solutions to ethical dilemmas, infrastructure for efficient integration of AI in workflows, and define decision points in the implementation process. [ABSTRACT FROM AUTHOR]
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- 2024
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183. Exploring the role of optimism as a protective factor for adolescent quality of life
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
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Pessimism ,Optimism ,Transition to adulthood ,Omvårdnad ,Health related quality of life ,Nursing ,humanities ,Family structure ,Adolescence - Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies. Som manuskript i avhandling. / As manuscript in dissertation.
184. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Subjects
coping ,Omvårdnad ,education ,secondary school adolescent ,Nursing ,school-related stress - Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future. Som manuskript i avhandling. / As manuscript in dissertation.
185. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
186. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
187. Current conceptualization and operationalization of adolescent’s social capital : a systematic review of self-reported instruments
- Author
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Ahlborg, Mikael, Nyholm, Maria, Nygren, Jens M., Svedberg, Petra, Ahlborg, Mikael, Nyholm, Maria, Nygren, Jens M., and Svedberg, Petra
- Abstract
Rationale: The interest in social capital in the context of adolescents has grown considerably in the research fields of the social sciences and public health over the past two decades. There is, however, a great heterogeneity in its conceptualization and operationalization for measurement and it is seldom comprehensively theorized for adolescents as a group distinct from adults. There has not yet been an attempt to systematically map and psychometrically evaluate the existing instruments for measuring social capital that have been developed and validated for adolescent samples. Aim: The aim of this systematic review was to identify and evaluate the design and psychometric properties of self-reported instruments for social capital specifically developed and validated for use among adolescents. Method: The design of this study was a systematic review guided by the COSMIN methodology for systematic reviews of Patient Reported Outcome Measures. The search included six electronic databases using the following inclusion criteria; instrument developed for or adapted to adolescent samples; explicit use of the term social capital in relation to instrument; description of development and validation process, and explicit focus on adolescents as a group distinct from adults. No time frame was applied. Results: 20 of the 1956 studies that were found were identified as describing the development and validation of a social capital instrument for adolescent samples. The common denominators for the included instruments were inclusion of constructs representing the cognitive dimension, as well as bonding social capital. Recurring contexts of interest were family, school, peers and neighbourhood/community. The results however reveal great variation in the design of the questionnaires, number of items and subscales and validation procedures. Adolescents were only involved in the development procedures of four instruments. Conclusion: There is a lack of social capital instruments that, Som manuskript i avhandling / As manuscript in thesis
188. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
189. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
190. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
191. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
192. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westerberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westerberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
193. A stakeholder perspective on adolescents’ needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
194. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
195. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
196. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
197. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
198. A stakeholder perspective on adolescents' needs for support to cope with school-related stress
- Author
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Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Wilhsson, Marie, Svedberg, Petra, and Nygren, Jens M.
- Abstract
Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach. Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future., Som manuskript i avhandling. / As manuscript in dissertation.
199. Exploring the role of optimism as a protective factor for adolescent quality of life
- Author
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Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, Nyholm, Maria, Häggström Westberg, Katrin, Wilhsson, Marie, Svedberg, Petra, Nygren, Jens M., Antony, Morgan, and Nyholm, Maria
- Abstract
This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL). Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups. This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies., Som manuskript i avhandling. / As manuscript in dissertation.
200. Dynamics of IgG-avidity and antibody levels after Covid-19.
- Author
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Löfström, Emma, Eringfält, Anna, Kötz, Arne, Wickbom, Fredrik, Tham, Johan, Lingman, Markus, Nygren, Jens M., and Undén, Johan
- Subjects
- *
COVID-19 , *COVID-19 pandemic , *HUMORAL immunity , *REVERSE transcriptase polymerase chain reaction - Abstract
• IgG antibodies are detectable six months after Covid-19. • IgG antibodies avidity index increases after Covid-19. • Avidity index is not suitable to differentiate between acute and previous covid-19 infection. A potentially important aspect of the humoral immune response to Covid-19 is avidity, the overall binding strength between antibody and antigen. As low avidity is associated with a risk of re- infection in several viral infections, avidity might be of value to predict risk for reinfection with covid-19. The purpose of this study was to describe the maturation of IgG avidity and the antibody-levels over time in patients with PCR-confirmed non-severe covid-19. Prospective longitudinal cohort study including patients with RT-PCR confirmed covid-19. Blood samples were drawn 1, 3 and 6 months after infection. Antibody levels and IgG-avidity were analysed. The majority had detectable s- and n-antibodies (88,1%, 89,1%, N = 75). The level of total n-antibodies significantly increased from 1 to 3 months (median value 28,3 vs 39,3 s/co, p <0.001) and significantly decreased from 3 to 6 months (median value 39,3 vs 17,1 s/co, p <0.001). A significant decrease in the IgG anti-spike levels (median value 37,6, 24,1 and 18,2 RU/ml, p <0.001) as well as a significant increase in the IgG-avidity index (median values 51,6, 66,0 and 71,0%, p <0.001) were seen from 1 to 3 to 6 months. We found a significant ongoing increase in avidity maturation after Covid-19 whilst the levels of antibodies were declining, suggesting a possible aspect of long-term immunity. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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