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Introduction: Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare bone pathology affecting small bones of hand and feet. This benign lesion needs to be distinguished from many malignant bone tumors as it poses a diagnostic dilemma due to its clinical, radiological, and histological picture. We report three cases of BPOP affecting the hand and foot. Case 1: A 21-year-old gentleman presented with painful swelling in the long finger of the right hand. A plain radiograph showed a radio dense mass which was later excised and diagnosis confirmed in histopathology. There was no recurrence in 2 years of follow-up. Case 2: A 5-year-old boy presented with painful swelling over the right ankle with no history of antecedent trauma. Following radiological evaluation, the patient was successfully treated with excision. Case 3: A 35-year-old lady presented with a painful swelling on the dorsal aspect of her hand which was gradually increasing in size. After radiological evaluation, the patient was successfully treated with excision and lesion confirmed to be BPOP on histological examination. She was symptom free without recurrence in up to 2 years of follow-up. Conclusion: Nora’s lesion is a rare pathology requiring high index of suspicion. Excision is the recommended mode of treatment. All our cases responded well with excision with immediate pain relief following surgery and no recurrence in up to 2 years of follow-up. Keywords: Nora, bizarre parosteal osteochondromatous proliferation, neoplasm, tumor, benign.

Denne masteroppgaven handler om kvinnelig representasjon eksemplifisert gjennom Henrik Ibsens Nora. Oppgaven er todelt. Den første delen er en historiografisk del. Gjennom forskning på en rekke historiske Nora-er trer tre hovedtyper fram: En Nora med røtter i melodramaet, en politisk Nora og en Nora portrettert gjennom psykologisk realisme. I oppgavens andre halvdel undersøker jeg mitt eget arbeid som skuespiller ved å analysere hva Nora representerte i Beijing i 1998. Da spilte jeg selv Nora i Mr. Wus oppsetning av Et Dukkehjem på The National Theatre of China (NTCC). Oppsummert er målet med denne oppgaven å analysere hva slags type kvinnelig representasjon Henrik Ibsens Nora står for, for å kunne analysere min egen Nora i Mr. Wus oppsetning i Beijing i 1998. Analysen viser at min Nora i Beijing er et resultat av kulturell og estetisk overføring med røtter tilbake til både melodramaet, Nora som politisk kraft og Nora representert gjennom psykologisk realisme. I tillegg reflekteres de politiske forholdene i Kina i 1998 ved at Nora både representerte en individuell kvinne og den vestlige verden. Gjennom Kommunistpartiets krav til hva Nora skulle representere, ble rollen formet for å forsterke de nasjonalistiske strømningene i Kina på slutten av 1990-tallet. Ettersom Et Dukkehjem i Beijing i 1998 er produksjon hvor en norsk skuespiller jobber sammen med et kinesisk ensemble, vil denne oppgaven også måtte drøfte noen av de utfordringene som oppsto rundt forståelsen av kvinnelig representasjon i en interkulturell kontekst. For å kunne analysere kvinnelig representasjon gjennom Nora-rollen, må rollen derfor også settes inn i en politisk og kulturell kontekst hvor estetisk overføring er et vesentlig begrep. Oppgaven konkluderer med at kvinnelig representasjon er et så sammensatt og intetsigende begrep at det er uten mening med mindre det analyseres ut ifra en estetisk, kulturell og politisk kontekst.

The web and its recent advancements represent a great opportunity to build universal, rich, multi-user and immersive Web3D/WebXR applications targeting Cultural Heritage field—including 3D presenters, inspection tools, applied VR games, collaborative teaching tools and much more. Such opportunity although, introduces additional challenges besides common issues and limitations typically encountered in this context. The “ideal” Web3D application should be able to reach every device, automatically adapting its interface, rendering and interaction models—resulting in a single, liquid product that can be consumed on mobile devices, PCs, Museum kiosks and immersive AR/VR devices, without any installation required for final users. The open-source ATON framework is the result of research and development activities carried out during the last 5 years through national and international projects: it is designed around modern and robust web standards, open specifications and large open-source ecosystems. This paper describes the framework architecture and its components, assessed and validated through different case studies. ATON offers institutions, researchers, professionals a scalable, flexible and modular solution to craft and deploy liquid web-applications, providing novel and advanced features targeting Cultural Heritage field in terms of 3D presentation, annotation, immersive interaction and real-time collaboration.

Cette contribution a l'intention d'approfondir la dynamique des relations établies par les premiers marins phéniciens avec les peuples autochtones de la Sardaigne jusqu'à l'arrivée de Carthage sur l' Île, dont la politique se définit depuis les phases initiales avec des caractères de conquête et de gestion directe des ressources du territoire. Donc, on se propose d'examiner une longue période historique qui s'est déroulée entre la fin du IXe siècle av. J.-C., lorsque les traces de la présence phénicienne en Sardaigne sont plus évidentes, et la fin du VIe siècle av. J.-C., lorsque Carthage, grâce à une stratégie militaire astucieuse, prendre possession des zones névralgiques de l'Île. Au cours de cette période considérable, les peuples autochtones jouent un rôle de premier plan dans les relations principalement pacifiques et d'intégration avec l'élément phénicien. Un laboratoire privilégié pour examiner ces dynamiques complexes est représenté dans le secteur sud-occidental de l'Île, grâce à la perspicacité et la prévoyance des spécialistes tels que Sabatino Moscati et Ferruccio Barreca. Les recherches réalisées par ces savants il y a plus d'un demi-siècle continuent de donner des résultats extrêmement intéressants et innovants dans le panorama des études qu'on veut examiner en détail pour offrir des éléments de réflexion stimulants dans le cadre de la conférence. D'autres scénarios particulièrement intéressants pour analyser la relation entre les Phéniciens et les Nuragiques sont représentés par l'emporium de Sant'Imbenia, au nord-ouest de l'Île, et par le sanctuaire de Monte Prama (Cabras) qui se situe exactement comme lieu clé pour contrôler le territoire immédiatement derrière la future colonie de Tharros.

The abstract is available here: https://uscholar.univie.ac.at/o:1430124

Purpose of review A growing numerical and complexity of patients requiring nonoperating room anesthesia (NORA) necessitates a multidisciplinary approach of a highly experienced team in a highly technological setting of the cathlab or radiology suite. These requirements are even more magnified in the context of the coronavirus disease 2019 (COVID-19) pandemic. Recent findings This review describes the aspects of risk stratification both in adults and children with respect to patient morphology, airway management, cardiorespiratory function and finally future developments, which could beneficially interfere with imminent management in NORA. Moreover, some particular features related to COVID-19 are also discussed. Summary Apart from a thorough preoperative assessment, preventive strategies and well-chosen monitoring should be implemented to preclude inadvertent events in sometimes high-risk patients. Timely preventive measures and early recognition of complications could only be achieved by a multidisciplinary cooperating team. In addition, the implementation of safety measurements due to the infectious transmission to both the patients and care givers is crucial.

Tackling antimicrobial resistance (AMR) represents a social responsibility aimed at renewing the antimicrobial armamentarium and identifying novel therapeutical approaches. Among the possible strategies, efflux pumps inhibition offers the advantage to contrast the resistance against all drugs which can be extruded. Efflux pump inhibitors (EPIs) are molecules devoid of any antimicrobial activity, but synergizing with pumps-substrate antibiotics. Herein, we performed an in silico scaffold hopping approach starting from quinolin-4-yloxy-based Staphylococcus aureus NorA EPIs by using previously built pharmacophore models for NorA inhibition activity. Four scaffolds were identified, synthesized, and modified with appropriate substituents to obtain new compounds, that were evaluated for their ability to inhibit NorA and synergize with the fluoroquinolone ciprofloxacin against resistant S. aureus strains. The two quinoline-4-carboxamide derivatives 3a and 3b showed the best results being synergic (4-fold MIC reduction) with ciprofloxacin at concentrations as low as 3.13 and 1.56 µg/mL, respectively, which were nontoxic for human THP-1 and A549 cells. The NorA inhibition was confirmed by SA-1199B ethidium bromide efflux and checkerboard assays against the isogenic pair SA-K2378 (norA++)/SA-K1902 (norA-). These in vitro results indicate the two compounds as valuable structures for designing novel S. aureus NorA inhibitors to be used in association with fluoroquinolones.

Il contributo prende in esame sotto il profilo morfologico e metrologico un’inedita mensa ponderaria reimpiegata in una muratura della Casa dell’Atrio Tetrastilo a Nora. Unico manufatto di tal genere ad oggi restituito dalla Sardegna, trovava forse originaria collocazione nell’horreum-insula lungo la strada diretta verso il porto o, in alternativa, nel complesso edilizio a vocazione commerciale dipendente dalla stessa domus., The essay overviews the morphological and metrological profile of an umpublished mensa ponderaria reused in one of Casa dell’Atrio Tetrastilo’s stonework, in Nora. Such object it’s the only one hailed from Sardinia and it probably founds its originating position in a horreum-insula along the road towards the harbour, otherwise in the commercial building depending on the domus itself.

Si presentano alcuni materiali provenienti dagli ambienti di una domus dell’area residenziale di Nora, ancora in fase di scavo. Numerosi frammenti d’intonaco sono stati ritrovati all’interno dell’ambiente A della casa del Pozzo (CdP), all’interno di un riempimento di scarico di materiali edili. Tra questi si trovano alcuni frammenti d’intonaco dipinto, un frammento d’intonaco graffito e un frammento di cornice in gesso., In this article are presented some materials from a domus in the residential area of Nora, still under excavation. Numerous fragments of plaster have been found inside the room A of the Casa del Pozzo (CdP), inside a filling of building materials. Among these are some fragments of painted plaster, a fragment of plaster with inscription on and a fragment of cornice.

In questo contributo verrà analizzata una piccola selezione di lucerne fittili in grado di evidenziare alcuni dei problemi che ancora persistono nello studio di questa classe ceramica. La scelta è ricaduta su alcune tra le più particolari per decorazione, tipologia e contesto di rinvenimento tra quelle emerse durante le più recenti indagini effettuate nel Quartiere Centrale di Nora: una di tipo punico dalle “case a mare”, due lucerne a disco dalle Terme Centrali e dalla “Casa del Direttore Tronchetti” e, sempre da quest’ultima domus, una di tipo tardo decorato a perline., In this paper a small selection of clay lamps – able to highlight some of the problems still persisting in this pottery class’s study – will be analysed. The choice fell on some of the most peculiar ones for their decoration, typological classification and context of finding among the artifacts discovered during the latest researches carried out in the Central District of Nora: a punic type from “case a mare”, two rounded-nozzle lamp from Central Baths and “Casa del Direttore Tronchetti” and, from this latter domus, also one of the late Warzenlampen type.

Tackling antimicrobial resistance (AMR) represents a social responsibility aimed at renewing the antimicrobial armamentarium and identifying novel therapeutical approaches. Among the possible strategies, efflux pumps inhibition offers the advantage to contrast the resistance against all drugs which can be extruded. Efflux pump inhibitors (EPIs) are molecules devoid of any antimicrobial activity, but synergizing with pumps-substrate antibiotics. Herein, we performed an in silico scaffold hopping approach starting from quinolin-4-yloxy-based Staphylococcus aureus NorA EPIs by using previously built pharmacophore models for NorA inhibition activity. Four scaffolds were identified, synthesized, and modified with appropriate substituents to obtain new compounds, that were evaluated for their ability to inhibit NorA and synergize with the fluoroquinolone ciprofloxacin against resistant S. aureus strains. The two quinoline-4-carboxamide derivatives 3a and 3b showed the best results being synergic (4-fold MIC reduction) with ciprofloxacin at concentrations as low as 3.13 and 1.56 &micro, g/mL, respectively, which were nontoxic for human THP-1 and A549 cells. The NorA inhibition was confirmed by SA-1199B ethidium bromide efflux and checkerboard assays against the isogenic pair SA-K2378 (norA++)/SA-K1902 (norA-). These in vitro results indicate the two compounds as valuable structures for designing novel S. aureus NorA inhibitors to be used in association with fluoroquinolones.

The paper reports the results of a multi-analytical characterization study on the renders constituting the waterproofing coatings of 11 cisterns located in the Punic-Roman archaeological site of Nora (Southern Sardinia, Italy). The multi-layer layout of the coatings is related both to the practice of putting several strata of render in a synchronic plastering phase, and to frequent restoration activities related to the prolonged use of the cisterns. The aims of this study are (a) to determine the compositional and textural properties of the binding materials, (b) to define the coating systems employed in diachronic plastering phases, and (c) to identify the role of diverse cultural influences in the modification of the render recipes along time. The combined interpretation of the results obtained through petrographic, mineralogical, microstructural and microchemical analyses allowed discriminating different render types employing various pozzolanic additives, whose utilization is related both to Punic and Roman technological practices. Furthermore, the cementation processes of the renders were studied through an in-detail mineralogical and spectroscopic characterization of their binder fractions. The results demonstrated that hydraulic reactions were often enhanced through specific treatments of the binding mixtures, such as the combined use of different pozzolanic additives, the adoption of comminution processes to increase their reactive specific surface and the use of saltwater to enhance silica and alumina activity in solution through pH increase. Such technological practices promoted in some cases not only the precipitation of Ca-based pozzolanic reaction products (C-S-H and AFm phases), but also the formation of nanostructured anthropogenic magnesium-silicate-hydrate (M-S-H) phyllosilicate gels, leading to a further increase of the cohesive properties of the binding mixtures. A combined interpretation of the results with the cistern construction chronologies confirmed that cistern coating techniques in Nora were still largely influenced by Punic traditions even two centuries after the Roman conquest of Sardinia.