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Inosine triphosphatase ( ITPA) genetic variants are strongly associated with ribavirin ( RBV)-induced anaemia during pegylated interferon ( PEG- IFN) plus RBV therapy. However, the treatment efficacy of ITPA genetic variants has not been fully explored. We enrolled 309 individuals infected with hepatitis C virus genotype 1, who were treated with PEG- IFN plus RBV for 48 weeks. The ITPA SNP: rs1127354 and IL28B SNP: rs8099917 were genotyped. We examined the risk factors for severe anaemia up to week 12 after the start of treatment and treatment efficacy. The incidence of severe anaemia, ≥3 g/dL reduction or <10 g/dL of haemoglobin ( Hb) up to week 12, was more frequent in patients with CC at rs1127354 [65% (145/224), 33% (73/224)] than in those with CA/ AA [25% (21/85), 6% (8/85)] ( P < 0.0001). ITPA genotype, pretreatment Hb level and age were independent predictive factors for severe anaemia: Hb < 10 g/dL. In IL28B favourable type, the sustained virologic response rate was higher in ≥60-year-old patients with CA/ AA than in those with CC [71% (22/31) vs 40% (26/65), P = 0.005], although there was no significant difference in treatment efficacy according to ITPA genetic variants in the <60-year-old patients. The proportion of patients administered ≥80% of the dosage of RBV was significantly higher in the patients with CA/ AA than in those with CC ( P = 0.025), resulting in a lower relapse rate. In conclusion, ITPA genetic variants were associated with severe RBV-induced anaemia and could influence the efficacy of PEG- IFN plus RBV treatment among elderly patients with IL28B favourable type. [ABSTRACT FROM AUTHOR]

In this work we shall address the ghost issue of F (R , G) gravity, which is known to be plagued with ghost degrees of freedom. These ghosts occur due to the presence of higher than two derivatives in the field equations, and can arise even when considering cosmological perturbations, where superluminal modes may arise in the theory. If we consider the quantum theory, the ghosts generate the negative norm states, which give the negative probabilities, and therefore the ghosts are physically inconsistent. Motivated by the importance of F (R , G) gravity for providing viable inflationary and dark energy phenomenologies, in this work we shall provide a technique that can render F (R , G) gravity theories free from ghost degrees of freedom. This will be done by introducing two auxiliary scalar fields, and by employing the Lagrange multiplier technique, the theory is ghost free in the Einstein frame. Also the framework can be viewed as a reconstruction technique and can be used as a method in order to realize several cosmological evolutions of interest. We demonstrate how we can realize several cosmologically interesting phenomenologies by using the reconstruction technique. [ABSTRACT FROM AUTHOR]

The antitumor effect of high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) is considered superior to that of conventional chemotherapy. However, the long-term benefits of this strategy in Japan remain unclear. Therefore, in this study, 109 cancer patients enrolled between 1989 and 1999 were treated with HDC and auto-PBSCT. Patients were evaluated for long-term survival and late-onset complications, including secondary malignancy. The mean number of CD34+ cells harvested per apheresis was larger in the group receiving high-dose cytosine arabinoside or high-dose etoposide plus granulocyte colony-stimulating factor (G-CSF) than in the group receiving conventional chemotherapy plus G-CSF. The 5-year overall survival rates for non-Hodgkin's lymphoma patients in first complete remission (CR) (83.2%), second or subsequent CR (74.1%), or first partial remission (PR) (66.7%) at the time of transplantation were significantly higher than those with no remission (35.7%) at the time of transplantation (first CR, P < .05; second or subsequent CR, P < .05; first PR, P < .05). The 5-year overall survival (OS) rates for breast cancer was 40.8%, and the disease-free survival rate was extremely low (8.8%). The 5-year OS rates for chemotherapy-sensitive and chemotherapy-resistant diseases at the time of transplantation were 32.7% and 35.7%, respectively, a difference that was not considered significant. The 5-year OS for germ cell tumor was 80.0%, and the disease-free survival rate was 77.9%. The rate of therapy-related death was 8.2%. The occurrence rate of secondary malignancy was 0.9%. Late-onset complications were observed in 4 cases (glomerulonephritis, interstitial pneumonitis, ulcerative colitis, and acute myelogenous leukemia). At 3.7%, the occurrence rate was not very high, but most complications of auto-PBSCT were life threatening and interfered with patients' quality of life. A careful follow-up is required for at least 2 years after transplantation, because the mean occurrence time of late-onset complications is 16.7 months posttransplantation. [ABSTRACT FROM AUTHOR]

We consider thermal effects in the propagation of gravitational waves on a cosmological background. In particular, we consider scalar field cosmologies and study gravitational modes near cosmological singularities. We point out that the contribution of thermal radiation can heavily affect the dynamics of gravitational waves giving enhancement or dissipation effects both at quantum and classical level. These effects are considered both in General Relativity and in modified theories like F (R) gravity which can be easily reduced to scalar–tensor cosmology. The possible detection and disentanglement of standard and scalar gravitational modes on the stochastic background are also discussed. [ABSTRACT FROM AUTHOR]