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1,274 results on '"Noda, Takeshi"'

152. A novel aqueous extract from rice fermented with Aspergillus oryzae and Saccharomyces cerevisiae possesses an anti-influenza A virus activity

Author

Shoji, Masaki, primary, Sugimoto, Minami, additional, Matsuno, Kosuke, additional, Fujita, Yoko, additional, Mii, Tomohiro, additional, Ayaki, Satomi, additional, Takeuchi, Misa, additional, Yamaji, Saki, additional, Tanaka, Narue, additional, Takahashi, Etsuhisa, additional, Noda, Takeshi, additional, Kido, Hiroshi, additional, Tokuyama, Takaaki, additional, Tokuyama, Takahito, additional, Tokuyama, Takashi, additional, and Kuzuhara, Takashi, additional

Published
2021
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156. Performance of poly-Si TFTs fabricated by SELAX

Author

Tai, Mitsuharu, Hatano, Mutsuko, Yamaguchi, Shinya, Noda, Takeshi, Seong-Jee Park, Shiba, Takeo, and Ohkura, Makoto

Subjects
Transistors -- Analysis, Thin films -- Analysis, Dielectric films -- Analysis, Polycrystalline semiconductors -- Analysis, Crystallization -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

The way the selectively enlarging laser crystallization (SELAX) method is used to form high-quality regions of poly-Si (polycrystalline silicon) is explained and the high performance and good uniformity of thin-film transistors (TFTs) fabricated on such regions is described. The delay time of the CMOS-inverter of SELAX TFTs is less than half that of excimer laser crystallization (ELC) TFTs.

Published
2004

166. Correction: ERdj8 governs the size of autophagosomes during the formation process

Author

Yamamoto, Yo-hei, primary, Kasai, Ayano, additional, Omori, Hiroko, additional, Takino, Tomoe, additional, Sugihara, Munechika, additional, Umemoto, Tetsuo, additional, Hamasaki, Maho, additional, Hatta, Tomohisa, additional, Natsume, Tohru, additional, Morimoto, Richard I., additional, Arai, Ritsuko, additional, Waguri, Satoshi, additional, Sato, Miyuki, additional, Sato, Ken, additional, Bar-Nun, Shoshana, additional, Yoshimori, Tamotsu, additional, Noda, Takeshi, additional, and Nagata, Kazuhiro, additional

Published
2020
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170. ERdj8 governs the size of autophagosomes during the formation process

Author

Yamamoto, Yo-hei, primary, Kasai, Ayano, additional, Omori, Hiroko, additional, Takino, Tomoe, additional, Sugihara, Munechika, additional, Umemoto, Tetsuo, additional, Hamasaki, Maho, additional, Hatta, Tomohisa, additional, Natsume, Tohru, additional, Morimoto, Richard I., additional, Arai, Ritsuko, additional, Waguri, Satoshi, additional, Sato, Miyuki, additional, Sato, Ken, additional, Bar-Nun, Shoshana, additional, Yoshimori, Tamotsu, additional, Noda, Takeshi, additional, and Nagata, Kazuhiro, additional

Published
2020
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176. Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

Author

Hsieh, Cheng-Lu, primary, Hsieh, Shu-Ying, additional, Huang, Hsuan-Min, additional, Lu, Shiou-Ling, additional, Omori, Hiroko, additional, Zheng, Po-Xing, additional, Ho, Yen-Ning, additional, Cheng, Yi-Lin, additional, Lin, Yee-Shin, additional, Chiang-Ni, Chuan, additional, Tsai, Pei-Jane, additional, Wang, Shu-Ying, additional, Liu, Ching-Chuan, additional, Noda, Takeshi, additional, and Wu, Jiunn-Jong, additional

Published
2020
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182. A ubiquitin-like system mediates protein lipidation

Author

Ichimura, Yoshinobu, Kirisako, Takayoshi, Takao, Toshifumi, Satomi, Yoshinori, Shimonishi, Yasutsugu, Ishihara, Naotada, Mizushima, Noboru, Tanida, Isei, Kominami, Eiki, Ohsumi, Mariko, Noda, Takeshi, and Ohsumi, Yoshinori

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Yoshinobu Ichimura [1, 2, 3]; Takayoshi Kirisako [1, 2, 3]; Toshifumi Takao [4]; Yoshinori Satomi [4]; Yasutsugu Shimonishi [4]; Naotada Ishihara [1]; Noboru Mizushima [1, 5]; Isei Tanida [6]; [...]

Published
2000
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189. Electrical Treeing Breakdown Characteristics of Epoxy/Spherical Boron Nitride with Card‐House Structure Composites.

Author

Murakami, Yoshinobu, Noda, Takeshi, Kawashima, Tomohiro, and Hozumi, Naohiro

Subjects
*TREES (Electricity), *ELECTRIC breakdown, *COMPOSITE structures, *BORON nitride, *BREAKDOWN voltage, *THERMAL conductivity, *THERMAL properties
Abstract

A spherical boron nitride with a card‐house structure (sBNch) was developed to enhance the filler's thermal property. To develop a thermal conductive insulating composite material with higher thermal conductive and acceptable electrical breakdown strength, an epoxy (EP)/an sBNch composite was produced. The treeing breakdown voltage of the composite using a needle‐rod electrode and the thermal conductivity were measured. The treeing breakdown voltage of EP/sBNch composite with the sBNch content of 50 wt% was higher than that of EP without the sBNch. The protrusion on the surface of the sBNch increases the effective distance between the electrodes. The thermal conductivity of EP/sBNch composite with the sBNch content of 50 wt% was higher than that of EP. From these results, the sBNch is considered a strong candidate filler of a thermally conductive composite. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Published
2022
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190. Acetylation of the influenza A virus polymerase subunit PA in the N‐terminal domain positively regulates its endonuclease activity.

Author

Hatakeyama, Dai, Shoji, Masaki, Ogata, Seiryo, Masuda, Takeshi, Nakano, Masahiro, Komatsu, Tsugunori, Saitoh, Ayaka, Makiyama, Kyoko, Tsuneishi, Hazuki, Miyatake, Asuka, Takahira, Mizuki, Nishikawa, Erina, Ohkubo, Ayana, Noda, Takeshi, Kawaoka, Yoshihiro, Ohtsuki, Sumio, and Kuzuhara, Takashi

Subjects
INFLUENZA A virus, INFLUENZA viruses, ENDONUCLEASES, POLYMERASES, RNA replicase, ACETYLATION, RNA polymerases, RECOMBINANT proteins
Abstract

The post‐translational acetylation of lysine residues is found in many nonhistone proteins and is involved in a wide range of biological processes. Recently, we showed that the nucleoprotein of the influenza A virus is acetylated by histone acetyltransferases (HATs), a phenomenon that affects viral transcription. Here, we report that the PA subunit of influenza A virus RNA‐dependent RNA polymerase is acetylated by the HATs, P300/CREB‐binding protein‐associated factor (PCAF), and general control nonderepressible 5 (GCN5), resulting in accelerated endonuclease activity. Specifically, the full‐length PA subunit expressed in cultured 293T cells was found to be strongly acetylated. Moreover, the partial recombinant protein of the PA N‐terminal region containing the endonuclease domain was also acetylated by PCAF and GCN5 in vitro, which facilitated its endonuclease activity. Mass spectrometry analyses identified K19 as a candidate acetylation target in the PA N‐terminal region. Notably, the substitution of the lysine residue at position 19 with glutamine, a mimic of the acetyl‐lysine residue, enhanced its endonuclease activity in vitro; this point mutation also accelerated influenza A virus RNA‐dependent RNA polymerase activity in the cell. Our findings suggest that PA acetylation is important for the regulation of the endonuclease and RNA polymerase activities of the influenza A virus. [ABSTRACT FROM AUTHOR]

Published
2022
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195. A protein conjugation system essential for autophagy

Author

Mizushima, Noboru, Noda, Takeshi, Yoshimori, Tamotsu, Tanaka, Yae, Ishii, Tomoko, George, Michael D., Klionsky, Daniel J., Ohsumi, Mariko, and Ohsumi, Yoshinori

Subjects
Saccharomyces -- Research, Proteins -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The process of autophagy for the bulk degradation of proteins is crucial for survival during starvation and cell differentiation. 14 autophagy-defective (apg) mutants of the Saccharomyces cerevisiae yeast have been isolated and the autophagic process examined at molecular level. A unique covalent-modification system is found to be necessary for autophagy to occur.

Published
1998

198. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

Author

50785970, 60646149, 00422410, 80215417, 10379092, Yamasoba, Daichi, Sato, Kei, Ichinose, Takuya, Imamura, Tomoko, Koepke, Lennart, Joas, Simone, Reith, Elisabeth, Hotter, Dominik, Misawa, Naoko, Akaki, Kotaro, Uehata, Takuya, Mino, Takashi, Miyamoto, Sho, Noda, Takeshi, Yamashita, Akio, Standley, Daron M., Kirchhoff, Frank, Sauter, Daniel, Koyanagi, Yoshio, Takeuchi, Osamu, 50785970, 60646149, 00422410, 80215417, 10379092, Yamasoba, Daichi, Sato, Kei, Ichinose, Takuya, Imamura, Tomoko, Koepke, Lennart, Joas, Simone, Reith, Elisabeth, Hotter, Dominik, Misawa, Naoko, Akaki, Kotaro, Uehata, Takuya, Mino, Takashi, Miyamoto, Sho, Noda, Takeshi, Yamashita, Akio, Standley, Daron M., Kirchhoff, Frank, Sauter, Daniel, Koyanagi, Yoshio, and Takeuchi, Osamu

Abstract

RNA-modulating factors not only regulate multiple steps of cellular RNA metabolism, but also emerge as key effectors of the immune response against invading viral pathogens including human immunodeficiency virus type-1 (HIV-1). However, the cellular RNA-binding proteins involved in the establishment and maintenance of latent HIV-1 reservoirs have not been extensively studied. Here, we screened a panel of 62 cellular RNA-binding proteins and identified NEDD4-binding protein 1 (N4BP1) as a potent interferon-inducible inhibitor of HIV-1 in primary T cells and macrophages. N4BP1 harbours a prototypical PilT N terminus-like RNase domain and inhibits HIV-1 replication by interacting with and degrading viral mRNA species. Following activation of CD4+ T cells, however, N4BP1 undergoes rapid cleavage at Arg 509 by the paracaspase named mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1). Mutational analyses and knockout studies revealed that MALT1-mediated inactivation of N4BP1 facilitates the reactivation of latent HIV-1 proviruses. Taken together, our findings demonstrate that the RNase N4BP1 is an efficient restriction factor of HIV-1 and suggest that inactivation of N4BP1 by induction of MALT1 activation might facilitate elimination of latent HIV-1 reservoirs.

Published
2019

199. Spontaneous Transition to a Correlated Phase of Skyrmions Observed in Real Space

Author

Moore, John N., Iwata, Hikaru, Hayakawa, Junichiro, Mano, Takaaki, Noda, Takeshi, Shibata, Naokazu, and Yusa, Go

Subjects
Condensed Matter - Strongly Correlated Electrons, Strongly Correlated Electrons (cond-mat.str-el), FOS: Physical sciences, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect
Abstract

We conduct photoluminescence microscopy that is sensitive to both electron and nuclear spin polarization to investigate the changes that occur in the magnetic ordering in the vicinity of the first integer quantum Hall state in a GaAs 2D electron system (2DES). We observe a discontinuity in the electron spin polarization and nuclear spin longitudinal relaxation time which heralds a spontaneous transition to a phase of magnetic skyrmions. We image in real space the spin phase domains that coexist at this transition, and observe hysteresis in their formation as a function of the 2DES's chemical potential. Based on measurements in a tilted magnetic field orientation, we found that the transition is protected by an energy gap containing the Zeeman energy, and conclude that the skyrmions here have formed as an ensemble., 4 figures

Published
2018

200. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

Author

Yamasoba, Daichi, Sato, Kei, Ichinose, Takuya, Imamura, Tomoko, Koepke, Lennart, Joas, Simone, Reith, Elisabeth, Hotter, Dominik, Misawa, Naoko, Akaki, Kotaro, Uehata, Takuya, Mino, Takashi, Miyamoto, Sho, Noda, Takeshi, Yamashita, Akio, Standley, Daron M., Kirchhoff, Frank, Sauter, Daniel, Koyanagi, Yoshio, and Takeuchi, Osamu

Subjects
CD4-Positive T-Lymphocytes, Macrophages, Receptors, Antigen, T-Cell, Gene Expression, Interferon-alpha, Nuclear Proteins, RNA-Binding Proteins, HIV Infections, RNA decay, Cell Line, Virus Latency, Mice, Protein Domains, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, HIV-1, Animals, Humans, RNA, Viral, Virus Activation, Restriction factors, RNA, Messenger
Abstract

RNA-modulating factors not only regulate multiple steps of cellular RNA metabolism, but also emerge as key effectors of the immune response against invading viral pathogens including human immunodeficiency virus type-1 (HIV-1). However, the cellular RNA-binding proteins involved in the establishment and maintenance of latent HIV-1 reservoirs have not been extensively studied. Here, we screened a panel of 62 cellular RNA-binding proteins and identified NEDD4-binding protein 1 (N4BP1) as a potent interferon-inducible inhibitor of HIV-1 in primary T cells and macrophages. N4BP1 harbours a prototypical PilT N terminus-like RNase domain and inhibits HIV-1 replication by interacting with and degrading viral mRNA species. Following activation of CD4+ T cells, however, N4BP1 undergoes rapid cleavage at Arg 509 by the paracaspase named mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1). Mutational analyses and knockout studies revealed that MALT1-mediated inactivation of N4BP1 facilitates the reactivation of latent HIV-1 proviruses. Taken together, our findings demonstrate that the RNase N4BP1 is an efficient restriction factor of HIV-1 and suggest that inactivation of N4BP1 by induction of MALT1 activation might facilitate elimination of latent HIV-1 reservoirs., 宿主がHIV-1感染を抑制する新たなメカニズムの解明 --N4BP1によるRNA分解とその調節がウイルス再活性化を調節する--. 京都大学プレスリリース. 2019-05-29.

Published
2018

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