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519 results on '"Nikkhah G"'

162. NOA-08 randomized phase III trial of 1-week-on/1-week-off temozolomide versus involved-field radiotherapy in elderly (older than age 65) patients with newly diagnosed anaplastic astrocytoma or glioblastoma (Methusalem).

Author

Wick, W., primary, Engel, C., additional, Combs, S. E., additional, Nikkhah, G., additional, Steinbach, J., additional, Kortmann, R., additional, Simon, M., additional, Wille, C., additional, Reifenberger, G., additional, and Weller, M., additional

Published
2010
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163. Chronic compression of the cervical myelon as complication of anterior interbody fusion (AIF): neurological improvement after late anterior decompression. Case report

Author

Madjid Samii, Nikkhah G, R. Schönmayr, and Völkening D

Subjects
musculoskeletal diseases, medicine.medical_specialty, Brown-Séquard syndrome, Arthrodesis, medicine.medical_treatment, Postoperative Complications, Cervical spondylosis, medicine, Humans, Spasticity, Spinal cord injury, Neurologic Examination, business.industry, Nerve Compression Syndromes, General Medicine, Middle Aged, medicine.disease, Spinal cord, Magnetic Resonance Imaging, Surgery, Intraoperative Injury, medicine.anatomical_structure, Spinal Fusion, Radicular pain, Female, Neurology (clinical), medicine.symptom, business, Spinal Nerve Roots, Spinal Cord Compression, Follow-Up Studies
Abstract

Severe neurological deficits directly related to intraoperative injury of the spinal cord and the nerve roots is a rare complication of anterior interbody fusion (AIF) in cervical spondylosis. A case of radiculopathy and Brown-Séquard Syndrome caused by a bone fragment following AIF in which a late anterior decompression and fusion of the cervical spine was performed four years after the initial operation is presented. Immediate relief of the radicular pain, improvement of the spasticity, and better sphincter control could be achieved. Therefore, patients with chronic anterior compression of an incomplete spinal cord injury after AIF may benefit from a late anterior decompression and fusion.

Published
1993

173. Anti-parkinson Drugs.

Author

Feuerstein, T. J. and Nikkhah, G.

Subjects
*DRUGS, *PARKINSON'S disease, *BIOCHEMICAL mechanism of action, *DRUG side effects, *ENCYCLOPEDIAS & dictionaries
Abstract

The article presents an encyclopedia entry for the term "anti-Parkinson drugs," which helps in the treatment of patients with Parkinson's disease. it explains the mechanisms of action of anti-Parkinson drugs. It discusses the clinical use of anti-Parkinson drugs, including its therapeutic and side effects.

Published
2004

174. Transplanted dopaminergic neurons: More or less?

Author

Brundin, P., Dunnett, S., Bjorklund, A., and Nikkhah, G.

Abstract

Author(s): P. Brundin [1]; S. Dunnett [3]; A. Bjorklund [2]; G. Nikkhah [4] To the editor Much debate has been generated from the results recently published by Freed et al. [...]

Published
2001
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176. Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture

Author

Nikkhah, G, Odin, P, Smits, A, Tingström, A, Othberg, A, Brundin, P, Funa, K, Lindvall, O, Nikkhah, G, Odin, P, Smits, A, Tingström, A, Othberg, A, Brundin, P, Funa, K, and Lindvall, O

Abstract

The effect of two isoforms of platelet-derived growth factor (PDGF), PDGF-AA and PDGF-BB, was tested on dissociated cell cultures of ventral mesencephalon from rat and human embryos. PDGF-BB but not PDGF-AA reduced the progressive loss of tyrosine hydroxylase- (TH)-positive neurons in rat and human cell cultures. The mean number of TH-positive cells in the PDGF-BB-treated rat culture was 64% and 106% higher than in the control cultures after 7 and 10 days in vitro, respectively. Corresponding figures for human TH-positive neurons were 90% and 145%. The influence of PDGF-BB was specific for TH-positive neurons and not a general trophic effect, since no change of either total cell number or metabolic activity was found. In PDGF-BB-treated cultures of human but not rat tissue the TH-positive neurons had longer neurites than observed in control or PDGF-AA-treated cultures. These data indicate that PDGF-BB may act as a trophic factor for mesencephalic dopaminergic neurons and suggest that administration of PDGF-BB could ameliorate degeneration and possibly promote axonal sprouting of these neurons in vivo.

Published
1993
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193. Radiotherapy in pediatric pilocytic astrocytomas. A subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH).

Author

Müller, K, Gnekow, A, Falkenstein, F, Scheiderbauer, J, Zwiener, I, Pietsch, T, Warmuth-Metz, M, Voges, J, Nikkhah, G, Flentje, M, Combs, S E, Vordermark, D, Kocher, M, and Kortmann, R-D

Abstract

Purpose: We evaluated clinical outcomes in the subset of patients who underwent radiotherapy (RT) due to progressive pilocytic astrocytoma within the Multicenter Treatment Study for Children and Adolescents with a Low Grade Glioma HIT-LGG 1996.Patients and Methods: Eligibility criteria were fulfilled by 117 patients. Most tumors (65 %) were located in the supratentorial midline, followed by the posterior fossa (26.5 %) and the cerebral hemispheres (8.5 %). Median age at the start of RT was 9.2 years (range 0.7-17.4 years). In 75 cases, external fractionated radiotherapy (EFRT) was administered either as first-line nonsurgical treatment (n = 58) or after progression following primary chemotherapy (n = 17). The median normalized total dose was 54 Gy. Stereotactic brachytherapy (SBT) was used in 42 selected cases.Results: During a median follow-up period of 8.4 years, 4 patients (3.4 %) died and 33 (27.4 %) experienced disease progression. The 10-year overall (OS) and progression-free survival (PFS) rates were 97 and 70 %, respectively. No impact of the RT technique applied (EFRT versus SBT) on progression was observed. The 5-year PFS was 76 ± 5 % after EFRT and 65 ± 8 % after SBT. Disease progression after EFRT was not influenced by gender, neurofibromatosis type 1 (NF1) status, tumor location (hemispheres versus supratentorial midline versus posterior fossa), age or prior chemotherapy. Normalized total EFRT doses of more than 50.4 Gy did not improve PFS rates.Conclusion: EFRT plays an integral role in the treatment of pediatric pilocytic astrocytoma and is characterized by excellent tumor control. A reduction of the normalized total dose from 54 to 50.4 Gy appears to be feasible without jeopardizing tumor control. SBT is an effective treatment alternative. [ABSTRACT FROM AUTHOR]

Published
2013
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194. Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

Author

Kahlert, U.D., Nikkhah, G., and Maciaczyk, J.

Subjects
*EPITHELIAL cells, *MESENCHYMAL stem cells, *GLIOMAS, *CANCER-related mortality, *PHENOTYPES, *CELLULAR signal transduction
Abstract

Abstract: Tumor dissemination and metastatic behavior account for the vast majority of cancer associated mortality. Epithelial tumors achieve this progressive state via epithelial-to-mesenchymal transition (EMT); however, the importance of this process in the neuroepithelial context is currently very controversially discussed. The review describes the current research status concerning EMT-like changes in malignant gliomas including the role of TWIST1, ZEB1/ZEB2 and SNAIl1/SNAIl2 as inducers for cell-invasiveness in GBMs. Furthermore, WNT/β-catenin signaling with its key-component FRIZZLED4 activating an EMT-like program in malignant gliomas and its relationship to the stem-like phenotype as well as discoveries on micro-RNA-level regulating the EMT-like process are discussed. [Copyright &y& Elsevier]

Published
2013
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196. Letter to the editor

Author

Tonn, J. C., primary, Nikkhah, G., additional, Darling, J. L., additional, and Schachenmayr, W., additional

Published
1993
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199. Incidence of vasculopathy in children with hypothalamic/chiasmatic gliomas treated with brachytherapy.

Author

Tacke, U., Karger, D., Spreer, J., Berlis, A., Nikkhah, G., and Korinthenberg, R.

Subjects
GLIOMA treatment, BRAIN tumors, RADIOISOTOPE brachytherapy, NEUROFIBROMATOSIS in children, IODINE, IRRADIATION, PATIENTS
Abstract

Introduction: External brain irradiation in children can cause cognitive decline, endocrine dysfunctions and second malignancies. A rare complication is cerebral vasculopathy, which occurs most often in patients with neurofibromatosis type 1. Interstitial radiotherapy using transient Iodine-125 implants is a radiotherapy option, called brachytherapy, offering excellent survival rates, but little is known on treatment-related morbidity, especially long time vascular changes. Patients and methods: Thirteen children with low-grade hypothalamic gliomas, four of them with neurofibromatosis type 1, were diagnosed and treated at the University Hospital Freiburg, Germany. They belong to a larger group of 44 children with suprasellar low-grade gliomas, treated with transient Iodine-125 seeds and include those who attended all routine follow-up examinations in Freiburg. After written informed consent from the parents or caregivers all patients underwent magnetic resonance imaging with angiographic techniques in 2001, 3 to 13 years after treatment. Results and discussion: Six out of 13 revealed cerebral vasculopathies, only one of them revealed symptoms of intermittent cerebral ischemia. Neurofibromatosis type 1 was present in one affected patient. The aetiology of the cerebral vascular changes is not fully understood so far. Tumour encasement, surgical damage and brachytherapy may contribute as a single risk factor or in combination. To get more information, we recommend MRA for artery vasculopathy at follow-up in all patients with suprasellar brain tumours irrespectively to their former treatment or presence of cerebrovascular symptoms. [ABSTRACT FROM AUTHOR]

Published
2011
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