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154. The 14N(n,p) reaction cross-section measurement at n TOF - CERN and its application to the design of a facility for neutron capture therapy

Author

Torres Sánchez, Pablo, Porras Sánchez, José Ignacio, Praena Rodríguez, Antonio Javier, and Universidad de Granada. Programa de Doctorado en Física y Ciencias del Espacio

Subjects
CERN, n_TOF, Neutron Capture Therapy
Abstract

Experimental nuclear data and simulations are crucial for new radiotherapies of cancer. In Boron Neutron Capture Therapy (BNCT), an accurate knowledge of neutron interaction with the elements present in body tissues is key for dosimetry. At low neutron energies, the reaction between neutrons and nitrogen, 14N(n,p), becomes a main component of the dose in most human tissues. There are several discrepancies in previous measurements of this reaction, which increase the uncertainty in dose estimations needed for treatment planning. Furthermore, Neutron Capture Therapy needs intense and clean neutron sources, suitable for therapy and with the possibility of being installed in hospital environments, getting over previous facilities at nuclear reactors. This thesis aims to contribute to these two topics. The nuclear data from a new measurement of the 14N(n,p) reaction, carried out at the n TOF Facility at CERN will be shown. The new high-accuracy data span from 8 meV to 800 keV, covering the range of interest for BNCT, including the thermal point (25.3 meV), whose cross-section value was found to be at 1.809 0.045 b. The implications of this new nuclear data to BNCT dosimetry will be explored via Monte Carlo simulations. A new Beam Shaping Assembly (BSA) will be proposed for a proton acceleratorbased neutron source, using 30 mA of 2.1 MeV protons onto a lithium target. This BSA produces a high-intensity and well-collimated neutron eld that also provides low contamination from gamma radiation and both thermal and fast neutrons. The spectrum of the beam coming out of the BSA aperture will be shown to be adequate for BNCT treatments, full lling all recommendations from the IAEA and also performing well in in-phantom dose simulations. The new nuclear data and the proposed neutron beam will be put together as input in order to develop a Treatment Planning System (TPS). The TPS processes medical images (DICOM) and runs Monte Carlo simulations of neutron transport through the model of the patient, allowing to compute dose estimations in the tumor and surrounding tissues, including organs at risk. The TPS will be used to perform a pilot test simulation with a realistic case of a Glioblastoma patient., El uso de datos nucleares experimentales y simulaciones es crucial para nuevas formas de radioterapia contra el cáncer. En la Terapia mediante Captura de Neutrones por Boro (BNCT, por sus siglas en ingles), un conocimiento preciso de la interacción de los neutrones con los elementos presentes en los tejidos corporales es clave para la dosimetría. La reacción de los neutrones con el nitrógeno, 14N(n,p), es una componente muy importante de la dosis en la mayor a de tejidos humanos para neutrones de baja energía. Existen discrepancias entre varias medidas anteriores de esta reacción, lo que aumenta la incertidumbre en las estimaciones de dosis necesarias para plantificar un tratamiento. Por otra parte, la Terapia por Captura de Neutrones necesita fuentes de neutrones intensas y limpias, adecuadas para terapia y que tengan la posibilidad de instalarse en el entorno hospitalario, a diferencia de las instalaciones anteriores que se han construido en reactores nucleares. Esta tesis pretende contribuir a resolver estos dos problemas. Se mostrarán los datos nucleares obtenidos en una nueva medida de la reacción 14N(n,p) realizada en las instalaciones de neutrones por tiempo de vuelo (n TOF) del CERN. Los nuevos datos de alta precisión abarcan el rango entre 8 meV y 800 keV, cubriendo por completo el rango de interés para BNCT, lo que incluye el punto térmico (25.3 meV), para el cual se ha encontrado que la sección e caz es 1.809 0.045 b. Las repercusiones de estos nuevos datos nucleares para la dosimetría en BNCT serán exploradas usando simulación Monte Carlo. Se propone un nuevo dispositivo conformador de haces (Beam Shaping Assembly, BSA), diseñado para una fuente de neutrones basada en acelerador, con 30 mA de protones a 2.1 MeV sobre un blanco de litio. Esta BSA produce un campo de neutrones colimado de alta intensidad que además presenta una contaminación baja por radiación gamma y neutrones rápidos o térmicos. Se mostrar a que el espectro del haz de neutrones a la salida de la apertura de la BSA es adecuado para tratamientos de BNCT, cumpliendo todas las recomendaciones del Organismo Internacional para la Energía Atómica (OIEA) y además mostrando buenos resultados con simulaciones de dosis en maniquíes. Tanto los nuevos datos nucleares como el haz de neutrones propuesto se combinarán como inputs en el desarrollo de un Sistema de Planificación de Tratamientos (TPS, por sus siglas en inglés). El TPS procesa imágenes médicas DICOM y ejecuta simulaciones Monte Carlo de transporte de neutrones en un modelo del paciente, lo que permite calcular la dosis en el tumor y los tejidos circundantes, incluyendo los órganos de riesgo. El TPS ser a usado para realizar una simulación de prueba piloto con un caso realista de paciente con Glioblastoma., Tesis Univ. Granada.

Published
2022

162. Gamma-Ray Dose Measurement with Radio-Photoluminescence Glass Dosimeter in Mixed Radiation Field for BNCT.

Author

Hiramatsu, K., Kusaka, S., Sato, F., Hoashi, E., Murata, I., and Yoshihashi, S.

Subjects
*PHOTOLUMINESCENCE measurement, *GAMMA rays -- Dose-response relationship, *NEUTRON capture therapy, *RADIATION doses, *IRRADIATION
Abstract

Accelerator based neutron sources (ABNS) are being developed as the next generation neutron irradiation system for BNCT. From the ABNS, unnecessary gamma-rays will be generated by neutron capture reactions, as well as fast neutrons. To control the whole-body radiation dose to the patient, measurement of gamma-ray dose in the irradiation room is necessary. In this study, the objective is to establish a method to measure gamma-ray dose separately in a neutron/gamma mixed field by using RPL glass dosimeter. For this purpose, we proposed a lead filter method which uses a pair of RPL glasses with and without a lead filter outside. In order to realize this method, the basic characteristics of glass dosimeter was verified in the gamma-ray field, before adapting it in the mixture field. From the result of the experiment using the lead filter, the simulation result especially for the case with a lead filter overestimated the absorbed does obtained from measurement. We concluded that the reason of the discrepancy is caused by existence of gradient of the dose distribution in the glass, and the difference of sensitivity to low-energy photon between measurement and theory. [ABSTRACT FROM AUTHOR]

Published
2017
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163. The 33S(n,α)30Si cross section measurement at n_TOF-EAR2 (CERN): From 0.01 eV to the resonance region.

Author

Sabaté-Gilarte, M., Praena, J., Porras, I., Quesada, J. M., Aberle, O., Andrzejewski, J., Audouin, L., Bécares, V., Bacak, M., Balibrea-Correa, J., Barbagallo, M., Barros, S., Bečvář, F., Beinrucker, C., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Camaño, M., and Calviño, F.

Subjects
*NEUTRON cross sections, *NEUTRON capture therapy, *MEDICAL physics, *PROTON synchrotrons
Abstract

The 33S(n,α)30Si cross section measurement, using 10B(n,α) as reference, at the n TOF Experimental Area 2 (EAR2) facility at CERN is presented. Data from 0.01 eV to 100 keV are provided and, for the first time, the cross section is measured in the range from 0.01 eV to 10 keV. These data may be used for a future evaluation of the cross section because present evaluations exhibit large discrepancies. The 33S(n,α)30Si reaction is of interest in medical physics because of its possible use as a cooperative target to boron in Neutron Capture Therapy (NCT). [ABSTRACT FROM AUTHOR]

Published
2017
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169. Gadolinium borate and iron oxide bioconjugates: Nanocomposites of next generation with multifunctional applications.

Author

Icten, Okan, Kose, Dursun Ali, Matissek, Stephan J., Misurelli, Jason A., Elsawa, Sherine F., Hosmane, Narayan S., and Zumreoglu-Karan, Birgul

Subjects
*IRON oxides, *BIOCONJUGATES, *NANOCOMPOSITE materials, *BIOCOMPATIBILITY, *FLUORESCEIN isothiocyanate
Abstract

Abstract The systematic investigations concerning the bioconjugation of GdBO 3 -Fe 3 O 4 nanocomposite and their in vitro biocompatibility with cancer cell lines are reported. The nanocomposites were prepared hydrothermally from magnetite (Fe 3 O 4 ), borax or boric acid and a Gd3+ salt. Bioconjugation processes were performed with citric acid and fluorescein isothiocyanate-doped silica, followed by the treatment with folic acid. Overall, the procedure involved “bare or PEGylated Fe 3 O 4 as the magnetic core” and “vaterite- or triclinic-type of GdBO 3 as the surface borate layer” for comparative evaluation of the results. The successful vectorization of the nanocomposite particles was demonstrated by quantitative and qualitative analytical data. All bioconjugates displayed soft ferromagnetic properties and negative zeta potential values that are appropriate for biological applications. The 10B and 157Gd contents were ca. 1014 atom/μg making them promising agents for BNCT, GdNCT and the combined GdBNCT. The Gd/Fe molar ratios (0.27–0.63) provided the capability for T1- or dual (T1 + T2) magnetic resonance imaging (MRI). In vitro studies were conducted to investigate the efficiency of targeted FA-conjugated versus non-FA conjugated nanoformulations on Mia-Pa-Ca-2, HeLa and A549 cells. Fluorescence microscopy and flow cytometry data unveiled the essential role of the zeta potential competing with folate targeting in the uptake mechanism. The bioconjugated nanoplatforms of GdBO 3 -Fe 3 O 4 composite, introduced herein, proved to have potential features of next generation agents for magnetically targeted therapy, fluorescence imaging, magnetic resonance imaging/diagnosis and Neutron Capture Therapy. Graphical abstract Unlabelled Image Highlights • Citrate- and folate-conjugated GdBO 3 -Fe 3 O 4 nanocomposites • High 10B and 157Gd contents for neutron capture therapy • Tunable Gd/Fe ratio for multi-modal MRI • Magnetic targeting, delivery and fluorescence imaging • No dangerous side effects in vitro [ABSTRACT FROM AUTHOR]

Published
2018
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170. Design of drug delivery systems for physical energy-induced chemical surgery.

Author

Nomoto, Takahiro and Nishiyama, Nobuhiro

Subjects
*DRUG delivery systems, *ANTINEOPLASTIC agents, *PHOTODYNAMIC therapy, *NEUTRON capture therapy, *MEDICAL imaging systems
Abstract

Physical energy-induced chemical surgery, a technique that induces antitumor effects by delivering a drug that exerts a therapeutic effect in response to physical energy and irradiating the diseased part with the corresponding physical energy, is a useful method to treat cancers with minimal systemic side effects. Among chemical surgery, photodynamic therapy (PDT) and neutron capture therapy (NCT) require a system that selectively delivers drugs to the diseased site. Although PDT and NCT have a similar concept, drug delivery systems (DDSs) for their purpose need different functions to solve the unique problems derived from the characteristics of respective physical energy. In this review, we will describe recent chemistry-based solutions including ours to overcome these challenges. [ABSTRACT FROM AUTHOR]

Published
2018
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171. Use of a Wire Scanner for Measuring a Negative Hydrogen Ion Beam Injected in a Tandem Accelerator with Vacuum Insulation.

Author

Bykov, T. A., Kasatov, D. A., Kolesnikov, Ia. A., Koshkarev, A. M., Makarov, A. N., Ostreinov, Yu. M., Sokolova, E. O., Sorokin, I. N., Taskaev, S. Yu., and Shchudlo, I. M.

Subjects
*ION beams, *VACUUM insulation, *TANDEM accelerators, *NEUTRON capture therapy, *CANCER treatment
Abstract

A modified wire scanner and a new methodical approach were used to measure the profile, current, and phase portrait of a negative hydrogen ion beam injected into a tandem accelerator with vacuum insulation. The effect of the space charge and spherical aberration of the focusing lenses on the negative hydrogen ion beam is revealed. Recommendations are given, whose implementation will make it possible to increase the current of the proton beam from 5 to 10 mA in the accelerator, which is sufficient for boron neutron capture therapy of malignant tumors. [ABSTRACT FROM AUTHOR]

Published
2018
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172. Synthesis and biological evaluation of closo-dodecaborate ibuprofen conjugate (DIC) as a new boron agent for neutron capture therapy.

Author

Ishii, Satomu and Nakamura, Hiroyuki

Subjects
*IBUPROFEN, *BORON compounds, *NEUTRON capture therapy, *AMIDE derivatives, *ANALYTICAL chemistry, *AQUEOUS solutions, *THERAPEUTICS
Abstract

A closo -dodecaborate ibuprofen conjugate (DIC) 1 was synthesized via amide bond formation between ibuprofen activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI) and 4-aminoethoxyethoxy- closo -dodecaborate 3 which was synthesized via the ring opening reaction of 1,4-dioxane- closo -dodecaborate complex 2 with ammonia in aqueous solution. DIC showed no significant binding affinity to HSA site 2, which is known as an ibuprofen binding site. DIC accumulated in HeLa cells in a time-dependent manner, and the boron concentration reached 0.68 μg/10 6  cells 6 h after administration. [ABSTRACT FROM AUTHOR]

Published
2018
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173. Nanostructured boron compounds for cancer therapy.

Author

Yinghuai Zhu and Hosmane, Narayan S.

Subjects
*NANOSTRUCTURED materials, *BORON compounds, *CANCER treatment, *NUCLEAR fission, *DRUG delivery systems, *NEUTRON capture therapy
Abstract

Nanostructured boron compounds have emerged as one of the promising frontiers in boron chemistry. These species possess unique physical and chemical properties in comparison with classical small boron compounds. The nanostructured boron composites generally have large amounts of boron contents and thus have the potential to deliver significant amount of boron to the tumor cells, that is crucial for boron neutron capture therapy (BNCT). In theory, BNCT is based on a nuclear capture reaction with the 10B isotope absorbing a slow neutron to initiate a nuclear fission reaction with the release of energetic particles, such as lithium and helium (a particles), which travel the distance of around nine microns within the cell DNA or RNA to destroy it. The recent studies have demonstrated that the nanostructured boron composites can be combined with the advanced targeted drug delivery system and drug detection technology. The successful combination of these three areas should significantly improve the BNCT in cancer treatment. This mini review summarizes the latest developments in this unique area of cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2018
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175. Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells.

Author

Terada, Shinichi, Tsunetoh, Satoshi, Tanaka, Yoshimichi, Tanaka, Tomohito, Kashiwagi, Hideki, Takata, Takushi, Kawabata, Shinji, Suzuki, Minoru, and Ohmichi, Masahide

Subjects
*BORON-neutron capture therapy, *CERVICAL cancer, *CANCER cells, *NEUTRON irradiation, *GYNECOLOGIC cancer, *HELA cells, *BORON
Abstract

There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma. • There is few studies of BNCT for gynecologic cancer. • BNCT is effective against cervical squamous and adenocarcinoma cells. • Selective boron uptake by cervical cancer tumors in vivo is possible. • BNCT may be effective to cervical carcinoma. [ABSTRACT FROM AUTHOR]

Published
2023
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180. Studies from Alma Mater Studiorum-University of Bologna Reveal New Findings on Cancer Gene Therapy [In Vivo Application of Carboranes for Boron Neutron Capture Therapy (BNCT): Structure, Formulation and Analytical Methods for Detection].

Subjects
BORON-neutron capture therapy, CARBORANES, CANCER genes, GENE therapy, CANCER treatment
Abstract

A recent study conducted by researchers at Alma Mater Studiorum-University of Bologna in Italy has focused on the use of carboranes in boron neutron capture therapy (BNCT) for cancer treatment. Carboranes have shown promise as effective boron agents in BNCT. The study examined the in vivo application of carboranes, including their biodistribution, pharmacokinetics, and pharmacodynamics. The researchers aimed to identify the strengths and weaknesses of carboranes in BNCT and determine the best strategies for future applications. This research provides valuable insights into the potential of carboranes in cancer gene therapy. [Extracted from the article]

Published
2023

181. Reports Summarize Cancer Therapy Study Results from Sardar Patel University (Boron Neutron Capture Therapy Anti-tumor Effect of Nanostructured Boron Carbon Nitride: a New Potential Candidate).

Abstract

Himachal Prades, India, Asia, Boron Neutron Capture Therapy, Cancer, Cancer Therapy, Drugs and Therapies, Health and Medicine, High-Energy Radiotherapy, Neutron Capture Therapy, Oncology, Pharmaceuticals, Radiotherapy, Therapy Keywords: Himachal Prades; India; Asia; Boron Neutron Capture Therapy; Cancer; Cancer Therapy; Drugs and Therapies; Health and Medicine; High-Energy Radiotherapy; Neutron Capture Therapy; Oncology; Pharmaceuticals; Radiotherapy; Therapy EN Himachal Prades India Asia Boron Neutron Capture Therapy Cancer Cancer Therapy Drugs and Therapies Health and Medicine High-Energy Radiotherapy Neutron Capture Therapy Oncology Pharmaceuticals Radiotherapy Therapy 2252 2252 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Drugs and Therapies - Cancer Therapy. [Extracted from the article]

Published
2023

182. Patent Issued for Ionizing-radiation beamline monitoring system (USPTO 11779778).

Subjects
BORON-neutron capture therapy, INVENTORS, EXTERNAL beam radiotherapy, INTRAOPERATIVE radiotherapy
Abstract

Keywords: Boron Neutron Capture Therapy; Business; Drugs and Therapies; Emerging Technologies; Health and Medicine; High-Energy Radiotherapy; Integrated Sensors LLC; Machine Learning; Machine Vision; Neutron Capture Therapy; Pharmaceuticals; Radiation Therapy; Radiotherapy; Therapy EN Boron Neutron Capture Therapy Business Drugs and Therapies Emerging Technologies Health and Medicine High-Energy Radiotherapy Integrated Sensors LLC Machine Learning Machine Vision Neutron Capture Therapy Pharmaceuticals Radiation Therapy Radiotherapy Therapy 4371 4371 1 10/30/23 20231030 NES 231030 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Pharma Business Week -- Integrated Sensors LLC (Palm Beach Gardens, Florida, United States) has been issued patent number 11779778, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. Low-energy neutrons are used, for example, in boron neutron capture therapy ("BNCT") and gadolinium neutron capture therapy ("Gd-NCT"). The ionizing-radiation beamline monitoring system of claim 17, wherein an entire roll-to-roll scintillator feeder spool and take-up spool system can be mechanically translated into or out of an incident ionizing-radiation beam transit area without breaking vacuum. [Extracted from the article]

Published
2023

183. Researchers from National Cancer Center Hospital Detail New Studies and Findings in the Area of Melanoma (Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first...).

Subjects
BORON-neutron capture therapy, CUTANEOUS malignant melanoma, CANCER hospitals, RESEARCH personnel, DRUG side effects, NEUTRON capture
Abstract

Keywords: Adverse Drug Reactions; Boron Neutron Capture Therapy; Cancer; Clinical Research; Clinical Trials and Studies; Drugs and Therapies; Health and Medicine; High-Energy Radiotherapy; Melanoma; Neutron Capture Therapy; Oncology; Radiotherapy EN Adverse Drug Reactions Boron Neutron Capture Therapy Cancer Clinical Research Clinical Trials and Studies Drugs and Therapies Health and Medicine High-Energy Radiotherapy Melanoma Neutron Capture Therapy Oncology Radiotherapy 2075 2075 1 10/30/23 20231030 NES 231030 2023 OCT 30 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- New study results on melanoma have been published. According to the news editors, the research concluded: "This case report shows that the accelerator-based BNCT may become a promising treatment modality for cutaneous malignant melanoma. [Extracted from the article]

Published
2023

184. New Neutron Capture Therapy Study Findings Reported from Budker Institute of Nuclear Physics (Dosimetry for boron neutron capture therapy developed and verified at the accelerator based neutron source VITA).

Abstract

Boron Neutron Capture Therapy, Health and Medicine, High-Energy Radiotherapy, Neutron Capture Therapy, Radiotherapy Keywords: Boron Neutron Capture Therapy; Health and Medicine; High-Energy Radiotherapy; Neutron Capture Therapy; Radiotherapy EN Boron Neutron Capture Therapy Health and Medicine High-Energy Radiotherapy Neutron Capture Therapy Radiotherapy 3325 3325 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on neutron capture therapy are discussed in a new report. [Extracted from the article]

Published
2023

185. Research Results from University of Tsukuba Update Understanding of Neutron Capture Therapy (Current development status of accelerator-based neutron source for boron neutron capture therapy).

Abstract

Owing to the need for high-intensity neutrons in treatment, compact accelerator-based neutron sources applicable to BNCT are being developed worldwide. Keywords: Boron Neutron Capture Therapy; Health and Medicine; High-Energy Radiotherapy; Neutron Capture Therapy; Radiotherapy EN Boron Neutron Capture Therapy Health and Medicine High-Energy Radiotherapy Neutron Capture Therapy Radiotherapy 1732 1732 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in neutron capture therapy. [Extracted from the article]

Published
2023

186. Findings from Osaka Medical and Pharmaceutical University Broaden Understanding of Brain Cancer (Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo -Dodecaborate on a Rat Brain Tumor Model).

Subjects
BORON-neutron capture therapy, BRAIN tumors, BRAIN cancer, NEUTRON capture
Abstract

Keywords: Boron Neutron Capture Therapy; Brain Cancer; Cancer; Health and Medicine; High-Energy Radiotherapy; Neutron Capture Therapy; Oncology; Radiotherapy EN Boron Neutron Capture Therapy Brain Cancer Cancer Health and Medicine High-Energy Radiotherapy Neutron Capture Therapy Oncology Radiotherapy 389 389 1 10/09/23 20231010 NES 231010 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- New research on brain cancer is the subject of a new report. Boron Neutron Capture Therapy, Brain Cancer, Cancer, Health and Medicine, High-Energy Radiotherapy, Neutron Capture Therapy, Oncology, Radiotherapy. [Extracted from the article]

Published
2023

187. Researchers from Kyoto University Report Recent Findings in Neutron Capture Therapy [Development of a Prompt Gamma-ray Detector With an 8 X 8 Array Labr3(Ce) Scintillator and a Multi-pixel Photon Counter for Boron Neutron Capture Therapy].

Abstract

Osaka, Japan, Asia, Boron Neutron Capture Therapy, Health and Medicine, High-Energy Radiotherapy, Radiotherapy, Neutron Capture Therapy Keywords: Osaka; Japan; Asia; Boron Neutron Capture Therapy; Health and Medicine; High-Energy Radiotherapy; Neutron Capture Therapy; Radiotherapy EN Osaka Japan Asia Boron Neutron Capture Therapy Health and Medicine High-Energy Radiotherapy Neutron Capture Therapy Radiotherapy 5362 5362 1 10/03/23 20231006 NES 231006 2023 OCT 6 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on High-Energy Radiotherapy - Neutron Capture Therapy have been published. [Extracted from the article]

Published
2023

188. Findings from Xi'an Jiaotong University Provides New Data on Neutron Capture Therapy [Simulations On the Thermal and Mechanical Performance of the Rotating Target System of Accelerator-driven Neutron Source for Boron Neutron Capture...].

Abstract

Shaanxi, People's Republic of China, Asia, Boron Neutron Capture Therapy, Health and Medicine, High-Energy Radiotherapy, Neutron Capture Therapy, Radiotherapy Keywords: Shaanxi; People's Republic of China; Asia; Boron Neutron Capture Therapy; Health and Medicine; High-Energy Radiotherapy; Neutron Capture Therapy; Radiotherapy EN Shaanxi People's Republic of China Asia Boron Neutron Capture Therapy Health and Medicine High-Energy Radiotherapy Neutron Capture Therapy Radiotherapy 1873 1873 1 09/25/23 20230929 NES 230929 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on High-Energy Radiotherapy - Neutron Capture Therapy. [Extracted from the article]

Published
2023

190. Patent Issued for Radiation detection system and radiation detection method for neutron capture therapy system (USPTO 11740370).

Abstract

"However, in this case, for example, when a dose rate of a neutron beam varies for some reasons after measuring the amount of activated gold of the gold wire, it may not be possible to cope with this variation and it may thus be difficult to irradiate an irradiation object with a neutron beam with a desired dose. As disclosed in the prior art, in a neutron capture therapy system, the dose of a neutron beam during irradiation is measured, for example, by attaching a gold wire for measuring a neutron beam to an irradiation object in advance, detaching the gold wire therefrom during the irradiation with a neutron beam, and measuring an amount of activated gold of the gold wire. "Accordingly, it is necessary to provide a radiation detection system and a radiation detection method for neutron capture therapy system capable of improving the accuracy of a neutron beam irradiation dose. [Extracted from the article]

Published
2023

191. Patent Application Titled "Systems, Devices, And Methods For Multi-Directional Dipole Magnets And Compact Beam Systems" Published Online (USPTO 20230268096).

Abstract

The example method further includes propagating the beam along the first beam travel path through a gradient portion of the dipole magnet to focus the beam for propagation to a downstream target. The dipole magnet of claim 21, wherein an entry point of the dipole magnet comprises one or more chamfers configured to create a gradient in a direction of the beam without creating a gradient transverse to the direction of the beam. Neutron beam systems used for BNCT typically include a target device that, when impacted by a beam of energetic protons, produces a neutron beam capable of treating cancerous tumors, including those associated with some of the most aggressive and difficult to treat cancer types. [Extracted from the article]

Published
2023

192. Researchers from National Atomic Energy Commission Detail Findings in Cancer [Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies].

Subjects
BORON-neutron capture therapy, NUCLEAR energy, BORON compounds, NEUTRON capture
Abstract

Keywords: Boron Compounds; Boron Neutron Capture Therapy; Cancer; Clinical Research; Clinical Trials and Studies; Health and Medicine; High-Energy Radiotherapy; Inorganic Chemicals; Neutron Capture Therapy; Oncology; Organic Chemicals; Radiotherapy EN Boron Compounds Boron Neutron Capture Therapy Cancer Clinical Research Clinical Trials and Studies Health and Medicine High-Energy Radiotherapy Inorganic Chemicals Neutron Capture Therapy Oncology Organic Chemicals Radiotherapy 1360 1360 1 09/11/23 20230911 NES 230911 2023 SEP 12 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on cancer. Boron Compounds, Boron Neutron Capture Therapy, Cancer, Clinical Research, Clinical Trials and Studies, Health and Medicine, High-Energy Radiotherapy, Inorganic Chemicals, Neutron Capture Therapy, Oncology, Organic Chemicals, Radiotherapy. [Extracted from the article]

Published
2023

193. Studies from Soochow University Describe New Findings in Nanoparticles [Tumor Eradication By Boron Neutron Capture Therapy With B-10-enriched Hexagonal Boron Nitride Nanoparticles Grafted With Poly(Glycerol)].

Abstract

For more information on this research see: Tumor Eradication By Boron Neutron Capture Therapy With B-10-enriched Hexagonal Boron Nitride Nanoparticles Grafted With Poly(Glycerol). Keywords: Jiangsu; People's Republic of China; Asia; Boron Neutron Capture Therapy; Boron Nitride; Chemicals; Emerging Technologies; Glycerol; Health and Medicine; High-Energy Radiotherapy; Nanoparticles; Nanotechnology; Neutron Capture Therapy; Radiotherapy; Sugar Alcohols EN Jiangsu People's Republic of China Asia Boron Neutron Capture Therapy Boron Nitride Chemicals Emerging Technologies Glycerol Health and Medicine High-Energy Radiotherapy Nanoparticles Nanotechnology Neutron Capture Therapy Radiotherapy Sugar Alcohols 1838 1838 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Nanotechnology - Nanoparticles have been published. [Extracted from the article]

Published
2023

194. Design of a filtration system to improve the dose distribution of an accelerator-based neutron capture therapy system

Author

Hu, Naonori, Tanaka, Hiroki, and Ono, Koji

Subjects
Neutrons, neutron moderator, Neoplasms, Humans, Water, Boron Neutron Capture Therapy, General Medicine, Neutron Capture Therapy, Monte Carlo Method, Monte Carlo simulation, thermal neutrons
Abstract

[Purpose] The aim of this study is to design and evaluate a neutron filtration system to improve the dose distribution of an accelerator-based neutron capture therapy system. [Methods] An LiF-sintered plate composed of 99%-enriched 6Li was utilized to filter out low-energy neutrons to increase the average neutron energy at the beam exit. A 5-mm thick filter to fit inside a 12-cm diameter circular collimator was manufactured, and experimental measurements were performed to measure the thermal neutron flux and gamma-ray dose rate inside a water phantom. The experimental measurements were compared with the Monte Carlo simulation, particle, and heavy ion transport code system. Following the experimental verification, three filter designs were modeled, and the thermal neutron flux and the biologically weighted dose distribution inside a phantom were simulated. Following the phantom simulation, a dummy patient CT dataset was used to simulate a boron neutron capture therapy (BNCT) irradiation of the brain. A mock tumor located at 4, 6, 8 cm along the central axis and 4-cm off-axis was set, and the dose distribution was simulated for a maximum total biologically weighted brain dose of 12.5 Gy with a beam entering from the vertex. [Results] All three filters improved the beam penetration of the accelerator-based neutron source. Filter design C was found to be the most suitable filter, increasing the advantage depth from 9.1 to 9.9 cm. Compared with the unfiltered beam, the mean weighted dose in the tumor located at a depth of 8 cm along the beam axis was increased by ∼25%, and 34% for the tumor located at a depth of 8 cm and off-axis by 4 cm. [Conclusion] A neutron filtration system for an accelerator-based BNCT system was investigated using Monte Carlo simulation. The proposed filter design significantly improved the dose distribution for the treatment of deep targets in the brain.

Published
2022

195. Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro

Author

H. I. Lavrenchuk, Yu. B. Shevchenko, A. L. Petranovs'ka, E. V. Pylypchuk, and I. V. Kozlovs'ka

Subjects
neutron capture therapy, magnet driven nanocomposites, proliferation, apoptosis, Atomic physics. Constitution and properties of matter, QC170-197
Abstract

Modifying effect of magnet driven nonocomposites containing 157Gd upon morpho-functional properties of cells was studied in the test system of L929 cell line culture. Modified with DTPA and DMSA magnet driven Gadolinium containing nonocomposites were found to have better cell biocompatibility: cells incubation with these NCA showed no toxicity in studied concentrations range, except the largest ones, at the same time decreas-ing adhesive properties of the cells. Decrease of mitotic activity along with preservation of control cell popula-tion density suggests synchronization of cell division was observed. Oleate sodium stabilized ferrite was found to cause destructive changes in the cell culture only at the concentration of 500 μg/ml, however it decreased mitotic activity in the cell culture by 3 to 5 times in the whole concentrations range. Magnet driven nanocomposites were shown to induct apoptosis in cell culture the extent of which depended upon agent concentration.

Published
2014

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