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153. “Malignant” Left Ventricular Hypertrophy Identifies Subjects at High Risk for Progression to Asymptomatic Left Ventricular Dysfunction, Heart Failure, and Death: MESA (Multi‐Ethnic Study of Atherosclerosis)

Author

Peters, Matthew N., primary, Seliger, Stephen L., additional, Christenson, Robert H., additional, Hong‐Zohlman, Susie N., additional, Daniels, Lori B., additional, Lima, Joao A.C., additional, de Lemos, James A., additional, Neeland, Ian J., additional, and deFilippi, Christopher R., additional

Published
2018
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156. Colaboradores

Author

Allahham, Mahmoud, Arps, Kelly, Ballantyne, Christie M., Belur, Agastya D., Bhat, Pavan, Carman, Teresa L., Chang, Anna Marie, Dadu, Razvan T., Dey, Amit K., Goyal, Aditya, Hoogeveen, Ron, Jneid, Hani, Jones, Peter H., Kleiman, Neal S., McEvoy, John W., Mehta, Nehal N., Milks, M. Wesley, Moyé, Lem, Nambi, Vijay, Neeland, Ian J., Oakland, Morgan, Patel, Kershaw V., Peacock, W. Frank, Riggs, Kayla A., Rohatgi, Anand, Saeed, Anum, Sekhon, Navdeep, Singh, Mohita, Wang, Zhe, Tang, W.H. Wilson, and Yu, Bing

Published
2020
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157. Association of Concentric Left Ventricular Hypertrophy With Subsequent Change in Left Ventricular End-Diastolic Volume

Author

Garg, Sonia, primary, de Lemos, James A., additional, Matulevicius, Susan A., additional, Ayers, Colby, additional, Pandey, Ambarish, additional, Neeland, Ian J., additional, Berry, Jarett D., additional, McColl, Roderick, additional, Maroules, Christopher, additional, Peshock, Ronald M., additional, and Drazner, Mark H., additional

Published
2017
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166. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity

Author

Ross, Robert, Neeland, Ian J., Yamashita, Shizuya, Shai, Iris, Seidell, Jaap, Magni, Paolo, Santos, Raul D., Arsenault, Benoit, Cuevas, Ada, Hu, Frank B., Griffin, Bruce A., Zambon, Alberto, Barter, Philip, Fruchart, Jean-Charles, Eckel, Robert H., Matsuzawa, Yuji, and Després, Jean-Pierre

Abstract

Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of death, this measurement is not routinely obtained in clinical practice. This Consensus Statement proposes that measurements of waist circumference afford practitioners with an important opportunity to improve the management and health of patients. We argue that BMI alone is not sufficient to properly assess or manage the cardiometabolic risk associated with increased adiposity in adults and provide a thorough review of the evidence that will empower health practitioners and professional societies to routinely include waist circumference in the evaluation and management of patients with overweight or obesity. We recommend that decreases in waist circumference are a critically important treatment target for reducing adverse health risks for both men and women. Moreover, we describe evidence that clinically relevant reductions in waist circumference can be achieved by routine, moderate-intensity exercise and/or dietary interventions. We identify gaps in the knowledge, including the refinement of waist circumference threshold values for a given BMI category, to optimize obesity risk stratification across age, sex and ethnicity. We recommend that health professionals are trained to properly perform this simple measurement and consider it as an important ‘vital sign’ in clinical practice.

Published
2020
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168. Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Author

Neeland, Ian J., Singh, Shruti, McGuire, Darren K., Vega, Gloria L., Roddy, Thomas, Reilly, Dermot F., Castro-Perez, Jose, Kozlitina, Julia, and Scherer, Philipp E.

Abstract

Aims/hypothesis: Ceramides are sphingolipids that contribute to insulin resistance in preclinical studies. We hypothesised that plasma ceramides would be associated with body fat distribution, insulin resistance and incident type 2 diabetes in a multi-ethnic cohort.Methods: A total of 1557 participants in the Dallas Heart Study without type 2 diabetes underwent measurements of metabolic biomarkers, fat depots by MRI and plasma ceramides by liquid chromatography-mass spectrometry. Diabetes outcomes were assessed after 7 years. Associations of body fat and insulin resistance with ceramides at baseline and of ceramides with incident diabetes outcomes were analysed.Results: The cohort had a mean age of 43 years, with 58% women, 45% black participants and a mean BMI of 28 kg/m2. Total cholesterol levels were associated with all ceramides, but higher triacylglycerols and lower HDL-cholesterol and adiponectin were associated only with saturated fatty acid chain ceramides (p < 0.0003). After adjusting for clinical characteristics and total body fat, visceral adipose tissue was positively associated with saturated fatty acid ceramides (per SD, β = 0.16 to 0.18) and inversely associated with polyunsaturated fatty acid ceramides (β = −0.14 to −0.16, p < 0.001 for all). Lower-body subcutaneous fat showed an opposite pattern to that for visceral fat. HOMA-IR was positively associated with saturated (β = 0.08 to 0.09, p < 0.001) and inversely with polyunsaturated ceramides (β = −0.06 to −0.07, p < 0.05). Ceramides were not associated with incident type 2 diabetes after adjustment for clinical factors.Conclusions/interpretation: Plasma ceramides demonstrate a biologically complex relationship with metabolic and imaging indicators of dysfunctional adiposity. The role of ceramides in a shared pathway of metabolic dysfunction linking visceral adiposity and insulin resistance requires further investigation. [ABSTRACT FROM AUTHOR]

Published
2018
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169. Effects of an oral biodegradable device used for 12 weeks on weight reduction, cardiovascular risk factors, satiety, snacking, and meal size

Author

Shirin, Haim, Neeland, Ian J., Ryan, Donna H., de Luis, Daniel, Lecube, Albert, Magos, Zoltan, Kenan, Yael, Amir, Ruthie, Cohen, Daniel L., and Johansen, Odd Erik

Abstract

The Epitomee Capsule (EC) is an, oral, self‐use, bio-degradable device for weight management, composed of absorbent polymers that self-expands in the stomach (pH-sensitive) and creates a triangular shape, space-occupying super-absorbent gel structure. A recent study reported that 42 % of study completers obtained >5 % weight reduction at 12 weeks. We performed exploratory analyses of this study to evaluate its effect on cardiovascular risk factors and on self-reported satiety, between-meal snacking and meal-size.

Published
2023
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177. Effect of treatment with rosiglitazone on high-sensitivity cardiac troponin levels among patients with type 2 diabetes mellitus

Author

Salahuddin, Usman I, primary, Pandey, Ambarish, additional, Ayers, Colby R, additional, See, Raphael, additional, Neeland, Ian J, additional, Gore, M Odette, additional, Grinsfelder, D Bennett, additional, Abdullah, Shuaib M, additional, Khera, Amit, additional, de Lemos, James A, additional, and McGuire, Darren K, additional

Published
2015
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179. Abstract 19981: Relationship of Cardiorespiratory Fitness and Adiposity With Left Ventricular Peak Systolic Strain in Middle-age Adults: The Dallas Heart Study

Author

Pandey, Ambarish, primary, Ayers, Colby, additional, Neeland, Ian J, additional, Matulevicius, Susan, additional, Rohatgi, Anand, additional, Peshock, Ronald, additional, Drazner, Mark, additional, Sarma, Satyam, additional, De Lemos, James, additional, and Berry, Jarett D, additional

Published
2015
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180. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement

Author

Neeland, Ian J, Ross, Robert, Després, Jean-Pierre, Matsuzawa, Yuji, Yamashita, Shizuya, Shai, Iris, Seidell, Jaap, Magni, Paolo, Santos, Raul D, Arsenault, Benoit, Cuevas, Ada, Hu, Frank B, Griffin, Bruce, Zambon, Alberto, Barter, Philip, Fruchart, Jean-Charles, and Eckel, Robert H

Abstract

Findings from epidemiological studies over the past 30 years have shown that visceral adipose tissue, accurately measured by CT or MRI, is an independent risk marker of cardiovascular and metabolic morbidity and mortality. Emerging evidence also suggests that ectopic fat deposition, including hepatic and epicardial fat, might contribute to increased atherosclerosis and cardiometabolic risk. This joint position statement from the International Atherosclerosis Society and the International Chair on Cardiometabolic Risk Working Group on Visceral Obesity summarises the evidence for visceral adiposity and ectopic fat as emerging risk factors for type 2 diabetes, atherosclerosis, and cardiovascular disease, with a focus on practical recommendations for health professionals and future directions for research and clinical practice. We discuss the measurement of visceral and ectopic fat, pathophysiology and contribution to adverse health outcomes, response to treatment, and lessons from a public health programme targeting visceral and ectopic fat. We identify knowledge gaps and note the need to develop simple, clinically applicable tools to be able to monitor changes in visceral and ectopic fat over time. Finally, we recognise the need for public health messaging to focus on visceral and ectopic fat in addition to excess bodyweight to better combat the growing epidemic of obesity worldwide.

Published
2019
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182. Electrocardiographic patterns of proximal left anterior descending artery occlusion in ST-elevation myocardial infarction may be modified by three-vessel coronary artery disease

Author

Neeland, Ian J., Sulistio, Melanie S., Stoller, Douglas, de Lemos, James A., Atkins, James M., and McGuire, Darren K.

Subjects
Male, Electrocardiography, Coronary Occlusion, Myocardial Infarction, Humans, Female, Article, Aged
Abstract

The electrocardiographic (ECG) pattern of ST-segment deviation in myocardial infarction is integral to the proper assessment of the location, extent, and functional significance of the infarct but may be modified by the underlying coronary artery anatomy.We describe the ECG findings in 2 cases of proximal left anterior descending (LAD) artery occlusion in ST-elevation myocardial infarction (STEMI) associated with 3-vessel coronary artery disease.Both patients had atypical ECG patterns of ST-segment elevation in leads V(2), I, and aVL and ST-segment depression with positive T waves suggestive of extensive subendocardial ischemia in leads II, III, aVF, and V(3) through V(6); acute proximal LAD occlusion and concomitant 3-vessel coronary artery disease were observed angiographically.Electrocardiographic changes in proximal LAD STEMI may be modified by the presence of significant atherosclerotic disease elsewhere in the coronary vasculature. Recognition of this ECG pattern may aid the clinician in the rapid identification of high-risk STEMI.

Published
2012

183. The CardioMetabolic Health Alliance

Author

Sperling, Laurence S., primary, Mechanick, Jeffrey I., additional, Neeland, Ian J., additional, Herrick, Cynthia J., additional, Després, Jean-Pierre, additional, Ndumele, Chiadi E., additional, Vijayaraghavan, Krishnaswami, additional, Handelsman, Yehuda, additional, Puckrein, Gary A., additional, Araneta, Maria Rosario G., additional, Blum, Quie K., additional, Collins, Karen K., additional, Cook, Stephen, additional, Dhurandhar, Nikhil V., additional, Dixon, Dave L., additional, Egan, Brent M., additional, Ferdinand, Daphne P., additional, Herman, Lawrence M., additional, Hessen, Scott E., additional, Jacobson, Terry A., additional, Pate, Russell R., additional, Ratner, Robert E., additional, Brinton, Eliot A., additional, Forker, Alan D., additional, Ritzenthaler, Laura L., additional, and Grundy, Scott M., additional

Published
2015
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184. Abstract 356: Effect of Treatment with Rosiglitazone on High-sensitivity Cardiac Troponin Levels Among Patients with Type 2 Diabetes Mellitus

Author

Salahuddin, Usman I, primary, Pandey, Ambarish, additional, Ayers, Colby R, additional, See, Raphael, additional, Neeland, Ian J, additional, Gore, M O, additional, Grinsfelder, Bennett, additional, Abdullah, Shuaib M, additional, Khera, Amit, additional, de Lemos, James A, additional, and McGuire, Darren K, additional

Published
2015
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186. Body Fat Distribution and Incident Cardiovascular Disease in Obese Adults

Author

Neeland, Ian J., primary, Turer, Aslan T., additional, Ayers, Colby R., additional, Berry, Jarett D., additional, Rohatgi, Anand, additional, Das, Sandeep R., additional, Khera, Amit, additional, Vega, Gloria L., additional, McGuire, Darren K., additional, Grundy, Scott M., additional, and de Lemos, James A., additional

Published
2015
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190. Defining coronary artery calcium concordance and repeatability - Implications for development and change: The Dallas Heart Study.

Author

Paixao, Andre R.M., Neeland, Ian J., Ayers, Colby R., Xing, Frank, Berry, Jarett D., de Lemos, James A., Abbara, Suhny, Peshock, Ronald M., and Khera, Amit

Abstract

Background Development and change of coronary artery calcium (CAC) are associated with coronary heart disease. Interpretation of serial CAC measurements will require better understanding of changes in CAC beyond the variability in the test itself. Methods Dallas Heart Study participants (2888) with duplicate CAC scans obtained minutes apart were analyzed to determine interscan concordance and 95% confidence bounds (ie: repeatability limits) for each discrete CAC value. These data derived cutoffs were then used to define change above measurement variation and determine the frequency of CAC development and change among 1779 subjects with follow up CAC scans performed 6.9 years later. Results Binary concordance (0 vs. >0) was 91%. The value of CAC denoting true development of CAC by exceeding the 95% confidence bounds for a single score of 0 was 2.7 Agatston units (AU). Among those with scores >0, the 95% confidence bounds for CAC change were determined by the following formulas: for CAC≤100AU: 5.6√CAC + 0.3*CAC – 3.1; for CAC>100AU: 12.4√CAC – 67.7. Using these parameters, CAC development occurred in 15.0% and CAC change occurred in 48.9%. Although 225 individuals (24.9%) had a decrease in CAC over follow up, only 1 (0.1%) crossed the lower confidence bound. Compared with prior reported definition of CAC development (ie: >0), the novel threshold of 2.7AU resulted in better measures of model performance. In contrast, for CAC change, no consistent differences in performance metrics were observed compared with previously reported definitions. Conclusion There is significant interscan variability in CAC measurement, including around scores of 0. Incorporating repeatability estimates may help discern true differences from those due to measurement variability, an approach that may enhance determination of CAC development and change. [ABSTRACT FROM AUTHOR]

Published
2017
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191. Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension: The Dallas Heart Study.

Author

Yuichiro Yano, Neeland, Ian J., Ayers, Colby, Peshock, Ronald, Berry, Jarett D., Lloyd-Jones, Donald M., Greenland, Philip, Mitchell, Gary F., Vongpatanasin, Wanpen, and Yano, Yuichiro

Abstract

The aim of this study was to assess characteristic impedance (Zc) of the proximal aorta in young and middle-aged individuals with isolated systolic hypertension (ISH). Zc is an index of aortic stiffness relative to aortic size. In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] <120 mm Hg and diastolic BP [DBP] <80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP <90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178). Zc, aortic arch pulse wave velocity, and minimum ascending aortic size were quantified using cardiovascular magnetic resonance. In multivariable-adjusted linear models, Zc was highest in the ISH group compared with the optimal BP, isolated diastolic hypertension, or systolic-diastolic hypertension groups (103.2±4.0 versus 68.3±2.1, 75.4±6.0, and 88.9±4.8 dyne*seconds/cm5, respectively; all P<0.05). The Zc-ISH association did not differ by race. Aortic pulse wave velocity was highest in the ISH group compared with the optimal BP, isolated diastolic hypertension, or systolic-diastolic hypertension groups (6.3±0.3 versus 4.3±0.1, 4.4±0.4 and 5.5±0.3 m/s, respectively; all P<0.05), whereas aortic size was similar across groups (all P>0.2). Results were similar in a subgroup of 1551 participants 18 to 49 years of age. In a multiracial population-based sample, we found evidence of a mismatch between proximal aortic stiffness and diameter in young and middle-aged adults with ISH. [ABSTRACT FROM AUTHOR]

Published
2017
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192. Effects of visceral adiposity on glycerol pathways in gluconeogenesis.

Author

Neeland, Ian J., Hughes, Connor, Ayers, Colby R., Malloy, Craig R., and Jin, Eunsook S.

Subjects
GLUCONEOGENESIS, OVERWEIGHT persons, OBESITY, FATTY liver, THERAPEUTICS, BLOOD plasma, DIAGNOSIS, PHYSIOLOGY
Abstract

Objective To determine the feasibility of using oral 13 C labeled glycerol to assess effects of visceral adiposity on gluconeogenic pathways in obese humans. Research Design and Methods Obese (BMI ≥ 30 kg/m 2 ) participants without type 2 diabetes underwent visceral adipose tissue (VAT) assessment and stratification by median VAT into high VAT-fasting (n = 3), low VAT-fasting (n = 4), and high VAT-refed (n = 2) groups. Participants ingested [U- 13 C 3 ] glycerol and blood samples were subsequently analyzed at multiple time points over 3 h by NMR spectroscopy. The fractions of plasma glucose (enrichment) derived from [U- 13 C 3 ] glycerol via hepatic gluconeogenesis, pentose phosphate pathway (PPP), and tricarboxylic acid (TCA) cycle were assessed using 13 C NMR analysis of glucose. Mixed linear models were used to compare 13 C enrichment in glucose between groups. Results Mean age, BMI, and baseline glucose were 49 years, 40.1 kg/m 2 , and 98 mg/dl, respectively. Up to 20% of glycerol was metabolized in the TCA cycle prior to gluconeogenesis and PPP activity was minor (< 1% of total glucose) in all participants. There was a 21% decrease in 13 C enrichment in plasma glucose in the high VAT-fasting compared with low VAT-fasting group ( p = 0.03), suggesting dilution by endogenous glycerol. High VAT-refed participants had 37% less 13 C enrichment in glucose compared with high VAT-fasting ( p = 0.02). There was a trend toward lower [1,2- 13 C 2 ] (via PPP) and [5,6- 13 C 2 ]/[4,5,6- 13 C 3 ] (via TCA cycle) glucose in high VAT versus low VAT groups. Conclusions We applied a simple method to detect gluconeogenesis from glycerol in obese humans. Our findings provide preliminary evidence that excess visceral fat disrupts multiple pathways in hepatic gluconeogenesis from glycerol. [ABSTRACT FROM AUTHOR]

Published
2017
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197. Association of prediabetes by fasting glucose and/or haemoglobin A1c levels with subclinical atherosclerosis and impaired renal function: Observations from the Dallas Heart Study

Author

Xing, Frank YF, primary, Neeland, Ian J, additional, Gore, M Odette, additional, Ayers, Colby R, additional, Paixao, Andre RM, additional, Turer, Aslan T, additional, Berry, Jarett D, additional, Khera, Amit, additional, de Lemos, James A, additional, and McGuire, Darren K, additional

Published
2013
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199. Disparities in statin prescription among patients with severe hypercholesterolemia in an integrated healthcare system

Author

Jean-Marie, Elizabeth M., Tashtish, Nour, Albar, Zainab, Miller, Drew, Sullivan, Claire, Al-Kindi, Sadeer, Rajagopalan, Sanjay, and Neeland, Ian J.

Abstract

Severe hypercholesterolemia (SH), defined as a low-density lipoprotein cholesterol (LDL-C) level ≥ 190 mg/dl, is associated with an increased risk for premature atherosclerotic cardiovascular disease. Despite guideline recommendations, many patients with severe hypercholesterolemia remain untreated. We conducted an observational analysis of a large pool of SH patients, exploring demographic and social factors contributing to disparities in the prescription of statin and other lipid-lowering therapies.

Published
2023
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200. Relation of Regional Fat Distribution to Left Ventricular Structure and Function

Author

Neeland, Ian J., primary, Gupta, Sachin, additional, Ayers, Colby R., additional, Turer, Aslan T., additional, Rame, J. Eduardo, additional, Das, Sandeep R., additional, Berry, Jarett D., additional, Khera, Amit, additional, McGuire, Darren K., additional, Vega, Gloria L., additional, Grundy, Scott M., additional, de Lemos, James A., additional, and Drazner, Mark H., additional

Published
2013
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