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Natural marine products show various biological properties such as antiphotoaging, antioxidant, anticancer, and anti-inflammation. This study evaluated the protective effects of the brown alga Carpomitra costata (Stackhouse) Batters (Sporochnaceae) against ultraviolet B (UVB)-provoked damage in human HaCaT keratinocytes. C. costata extract (CCE) effectively reduced superoxide anion, hydroxyl radical, and UVB-stimulated intracellular reactive oxygen species (ROS) levels. CCE also restored the expression and activity of UVB-suppressed antioxidant enzymes. Furthermore, CCE decreased UVB-triggered oxidative damage to cellular components including DNA, protein, and lipid and defended the cells against mitochondrial membrane depolarization-medicated apoptosis. The results of this study indicate that CCE can safeguard human keratinocytes against UVB-induced cellular damage via a potent antioxidant mechanism. CCE may find utility as part of a therapeutic arsenal against the damaging effects of UVB radiation on the skin.

This study was intended to assess the anti-inflammatory properties of 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (Comp) isolated from Ulva pertusa Kjellman on production of pro-inflammatory cytokines. Comp revealed remarkable inhibitory effects on production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Comp pre-treatment in the CpG DNA-stimulated BMDCs exhibited strong inhibition of interleukin (IL)-12 p40 and IL-6 production with IC50 values ranging from 7.57 +/- 0.2 to 10.83 +/- 0.3, respectively. It revealed an inhibitory effect on the phosphorylation of ERK1/2, JNK1/2, and p38, and on activator protein (AP)-1 reporter activity. Comp displayed noteworthy inhibitory effects on phosphorylation and degradation of IB, and on NF-B reporter activity. In summary, these data propose that Comp has substantial anti-inflammatory properties and warrants further study concerning its potential use as a therapeutic agent for inflammation-associated maladies.

Purpose A fixed-dose combination of a stain and an antihypertensive drug may be useful for the treatment of patients with hypertension and hyperlipidemia. It may also improve patient drug compliance to help control risk factors of cardiovascular disease. This study was designed to evaluate the blood pressure–lowering and cholesterol-lowering effect of a fixed-dose combination of irbesartan-atorvastatin compared with monotherapy by either agent over an 8-week treatment period. Methods Patients with comorbid hypertension and hypercholesterolemia were screened for this randomized, double-blind, Phase III study. Eligible study patients were randomly assigned to test groups receiving a combination of irbesartan 300 mg and atorvastatin 40 mg or 80 mg (IRB300 + ATO40 and IRB300 + ATO80). Comparator groups comprised monotherapy groups with irbesartan 300 mg (IRB300) or atorvastatin 40 mg (ATO40) or atorvastatin 80 mg (ATO80), or placebo. Patients who were eligible at screening were subjected to a 4- to 6-week washout period before commencing 8 weeks of therapy per their assigned group. The primary efficacy end points were percent change in LDL-C and sitting diastolic blood pressure (DBP) levels from baseline to end of therapy. Tolerability profiles of combination therapy were compared with other groups. Findings A total of 733 patients with comorbid hypertension and hypercholesterolemia were screened for this study; 230 eligible patients were randomized to treatment. The mean age of patients was 58.9 (8.5) years, and their mean body mass index was 25.8 (3.2) kg/m2. More than two thirds (70.9%) of the study patients were male. Mean LDL-C and sitting DBP levels at baseline were 149.54 (29.19) mg/dL and 92.32 (6.03) mm Hg, respectively. Percent reductions in LDL-C after 8 weeks were 46.74% (2.06%) in the IRB300 + ATO40 group and 48.98% (2.12%) in the IRB300 + ATO80 group; these values were 47.13% (3.21%) and 48.30% (2.98%) in the ATO40 and ATO80 comparator groups. Similarly, a reduction in sitting DBP after 8 weeks was –8.50 (1.06) mm Hg in the IRB300 + ATO40 group and 10.66 (1.08) mm Hg in the IRB300 + ATO80 group compared with 8.40 (1.65) mm Hg in the IRB300 group. The incidence rate for treatment-emergent adverse events was 22.27% and was similar between the monotherapy and combination groups. Implications A once-daily combination product of irbesartan and atorvastatin provided an effective, safe, and more compliable treatment for patients with coexisting hypertension and hyperlipidemia. ClinicalTrials.gov identifier: NCT01442987.

Previous research showed that resveratrol (trans-3,4',5-trihydroxystilbene) and pinostilbene (trans-3-methoxy-4',5-dihydroxystilbene) were able to inhibit tyrosinase directly; however, anti-melanogenic effects of pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene) and resveratrol trimethyl ether (RTE) have not been compared. To investigate the hypopigmentation effects of pterostilbene and RTE, melanin contents and intracellular tyrosinase activity were determined by western blot analysis. Firstly, pterostilbene showed the inhibitory effects on α-melanocyte stimulating hormone (MSH)-induced melanin synthesis stronger than RTE, resveratrol, and arbutin. Pterostilbene inhibited melanin biosynthesis in a dose-dependent manner in α-MSH-stimulated B16/F10 murine melanoma cells. Specifically, melanin content and intracellular tyrosinase activity were inhibited by 63% and 58%, respectively, in response to treatment with 10 μM of pterostilbene. The results of western blot analysis indicated that pterostilbene induced downregulation of tyrosinase protein expression and suppression of α-MSH-stimulated melan-A protein expression stronger than RTE or resveratrol. Based on these results, our study suggests that pterostilbene can induce hypopigmentation effects more effectively than resveratrol and RTE, and it functions via downregulation of protein expression associated with hyperpigmentation in α-MSH-triggered B16/F10 murine melanoma cells.

This study aims to investigate the photoprotective properties of a Lomentaria hakodatensis ethanol extract (LHE) against ultraviolet B (UVB) radiation-induced cellular damage in human HaCaT keratinocytes. LHE exhibited scavenging activity against intracellular reactive oxygen species (ROS), which were generated by either hydrogen peroxide (H2O2) or UVB radiation. Moreover, LHE scavenged superoxide anion generated by the xanthine/xanthine oxidase system and hydroxyl radical generated by the Fenton reaction (FeSO4 + H2O2). Furthermore, LHE exhibited UVB absorptive properties and attenuated injury to cellular components (e.g., lipids, proteins and DNA), resulting from UVB-induced oxidative stress. In addition, LHE reduced apoptosis in response to UVB, as shown by decreased DNA fragmentation and the formation of apoptotic bodies. These results suggest that LHE protects human keratinocytes against UVB-induced oxidative stress by scavenging ROS and absorbing UVB rays; thereby reducing damage to biological components.

The present study was designed to evaluate the molecular mechanisms of the action of acanthoic acid (ACAN) from Acanthopanax koreanum (Araliaceae) against HL-60 human promyelocytic leukaemia cells. ACAN reduced the proliferation of HL-60 cells in a dose- and time-dependent manner accompanied by the induction of apoptosis. Possible mechanisms of ACAN-induced apoptosis were also examined. The results showed that ACAN-induced the phosphorylation of members of the mitogen-activated protein kinase (MAPK) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK). A specific p38 MAPK inhibitor (SB203580) significantly blocked ACAN-induced apoptosis and cell viability, whereas an ERK inhibitor (PD98059) and JNK inhibitor (SP600125) had no effect. Moreover, ACAN induced the cleavage of caspase-3 and poly-ADP-ribose polymerase (PARP), and decreased the level of Bcl-xL, but these effects were inhibited by SB203580 pre-treatment. These results strongly suggest that ACAN may have cancer chemopreventive and therapeutic potential, due to its ability to activate the p38 MAPK-mediated signalling pathways.

Summary Background Ultraviolet B generates reactive oxygen species by interacting with water in irradiated skin tissues and cells in turn causes lipid peroxidation, protein modification and further DNA damage. Purpose This study examined the cytoprotective effects of phloroglucinol (1,3,5-trihydroxybenzene) on ultraviolet B-irradiated cultured human keratinocytes. Methods The human keratinocyte cell line HaCaT cells were treated with 10 μM of phloroglucinol. After 1 h, the cells were irradiated with ultraviolet B light at 30 mJ/cm2 and incubated at 37°C. Results Phloroglucinol scavenged both the superoxide anion and hydroxyl radical in a cell-free system and ultraviolet B-induced intracellular reactive oxygen species. Phloroglucinol reduced ultraviolet B-generated lipid peroxidation, protein modification and DNA strand breaks. The enzymatic effects of phloroglucinol restored cellular glutathione levels, superoxide dismutase and catalase activities, which were impaired by ultraviolet B radiation. Conclusion: Phloroglucinol provides the protective effects in human keratinocyte cell line exposed to ultraviolet B radiation, suggesting that phloroglucinol can be used as a photoprotective agent.

In this study, Co 60 gamma-ray induced loss on Ge-doped single mode (SM) fiber has been measured. Gamma-ray is irradiated for 4 hours at the dose rate of 0.5 kGy/hr, 2 kGy/hr, 8 kGy/hr. Consequently, gamma-ray induced loss based on radiation effects in Ge-doped SM fiber occur significantly. Furthermore, dose rate effect was observed, that dose rate using the same total dose increased higher, then optical fiber loss increased more. Also annealing effect was observed, that the loss after irradiation, increased higher, then the recovery rate of loss was increased. This results are foreseen to be base data in the future radiation-hardened optical fiber study.

In this paper, we performed a study of damage assessment model development to analyze the initial nuclear pulse radiation damage to semiconductor devices for military weapon systems. At first we modeled(M) the nuclear pulse radiation and diode device, and simulated(S) the output characteristics of the device to the input. Then the manufactured diodes which had the same characteristics with the modeled one were irradiated to the similar pulsed type radiation and their output signals were measured simultaneously. Error between the M & S results and the measured values of the analysis was 22.9%. Through the error value we could confirm that the damage assessment model simulated the TREE effects with a quite accuracy.

The aim of this study was to investigate the protective effects of the ethanol extract of the red algae Chondracanthus tenellus (Harvey) Hommersand (CTE) on cultured human keratinocyte cell line. The cellular protection conferred by CTE was evidenced by the ability of the extract to absorb ultraviolet B (UVB; 280-320 nm) and to scavenge the radical 1,1-diphenyl-2-picrylhydrazyl, as well as intracellular reactive oxygen species (ROS), induced by either hydrogen peroxide (H(2)O(2)) or UVB radiation. In addition, both superoxide anion generated by the xanthine/xanthine oxidase system and hydroxyl radical generated by the Fenton reaction (FeSO(4) + H(2)O(2)) were scavenged by CTE, as confirmed using electron spin resonance spectrometry. In the human keratinocyte cell line, CTE decreased the degree of injury resulting from UVB-induced oxidative stress to lipids, proteins, and DNA. CTE-treated cells also showed a reduction in UVB-induced apoptosis, as exemplified by fewer apoptotic bodies and less DNA fragmentation. Taken together, these results suggest that CTE confers protection on the human keratinocyte cell line against UVB-induced oxidative stress by absorbing UVB ray and scavenging ROS, thereby reducing injury to cellular constituents.

In this study, we carried out transient radiation test for identify failure situation by a transient radiation effect on operational amplifier devices. This experiments were carried out using a 60 MeV electron beam pulse of the LINAC(Linear Accelerator) facility in the Pohang Accelerator Laboratory. In this test, we has found that a serious failure as a burn-out effect due to overcurrent on the partial electronic devices.

The Stereo X-ray inspection system is designed for effectively providing the additional information of objects than the conventional inspection system that offers only 2D cross-section of objects. We studied the geometric improvement of the stereo X-ray inspection system, the stereo matching algorithm of the single object using the edge and the volume reconstruction method for the inspected object. In this paper, we conduct a matching algorithm to find the correspondences between the images and reconstruct 3-D shapes of real objects using the stereo X-ray images. Also, we apply a new 3D reconstruction algorithm for the discrimination of two objects. For the separation of the overlapping objects, we calculate the vector of the object and divide inner and outer voxel of objects. And for the elimination of the overlapping area, we study the reconstruct 3D shapes using the threshold based Z-axis. The experimental results show that the proposed technique can enhance the accuracy of stereo matching and give more efficient visualization for overlap objects in the restricted environment.

This study was designed to investigate the mushroom tyrosinase inhibitory activity for the constituents isolated from Neolitsea aciculata. The stems of N. aciculata was extracted with aqueous ethanol and subjected to chromatographic separation, which led to the isolation of 11 compounds: methyl linoleate (1), catechin (2), epicatechin (3), afzelin-7-O-glucopyranoside (4), 2',3'-di-(p-coumaroyl)afzelin (5), 2'-p-coumaroylafzelin (6), feruloyl tyramine (7), β-sitosterol (8), daucosterol (9), oleic acid (10), and trilaurin (11). Their structures were elucidated on the basis of spectroscopic studies as well as by comparison with the data available in the literature. Among these isolates, compounds 5 and 6 were identified as potent mushroom tyrosinase inhibitors with IC₅₀ values of 0.067 and 0.080 mM, respectively. The inhibition kinetics, analysed by Lineweaver-Burk plots, indicated that compounds 5 and 6 are competitive tyrosinase inhibitors when using l-tyrosine as a substrate. Notably, compounds 1-11 were isolated for the first time from this plant. These results provide evidence that this plant might be a potential source of anti-melanogenesis agents.

Photo-protective properties of Polysiphonia morrowii ethanol extract (PME) against ultraviolet B (UVB) radiation-induced cellular damage were investigated in human HaCaT keratinocytes. PME exhibited scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species induced by either hydrogen peroxide (H2O2) or UVB radiation. In addition, PME scavenged superoxide anion generated by xanthine/xanthine oxidase system and hydroxyl radical generated by the Fenton reaction (FeSO4 + H2O2), both of which were detected using electron spin resonance spectrometry. Moreover, PME, which scavenges H2O2, was shown to contain the antioxidant compound 3-bromo-4,5-dihydroxylbenzaldehyde, possibly accounting for scavenging actions. PME also restored the levels of catalase and superoxide dismutase protein expression and activity that were decreased by UVB radiation. PME reduced UVB-induced apoptosis, as shown by decreased apoptotic bodies and DNA fragmentation. These results indicate that PME protects human keratinocytes against oxidative stress induced by UVB radiation through the enhancement of antioxidant systems.

Transient radiation is emitted during a nuclear explosion. Transient radiation causes a fatal error in the CMOS circuit as a Upset and Latch-up. In this paper, transient radiation NMOS, PMOS, INVERTER SPICE model was proposed on the basisi of transient radiation effects analysis using TCAD(Technology Computer Aided Design). Photocurrent generated from the MOSFET internal PN junction was expressed to the current source and Latch-up phenomenon in the INVERTER was expressed to parasitic thyristor for the transient radiation SPICE model. For example, the proposed transient radiation SPICE model was applied to CMOS NAND circuit.. SPICE simulated characteristics were similar to the TCAD simulation results. Simulation time was reduced to 120 times compared to TCAD simulation.Key Words : CMOS, TCAD, Latch-up, Transient Radiation Effects (TRE)† 교신저자, 정회원 : 전북대학교 전자공학부 부교수 공학박사E-mail : kiee@kiee.or.kr *비 회 원 : 전북대학교 전자공보공학부 박사과정한국원자력연구원 고급전문인력** 정 회 원 : 한국원자력연구원 책임연구원***정 회 원 : 한국과학기술원 박사과정 접수일자 : 2011년 9월 27일 최종완료 : 2012년 1월 31일

In this study the effect of heartwood-coating (HCO), vapor-dam (VD), bark-remaing (BR) and bark-remaining- coating (BRC) treatments were evaluated during air circulating oven-drying of hollowed round-post of Korean red pine. Hollowed round-post could be dried from the green condition to approximately 6% MC within 84 to 156 hours for the UC, HCO and VD specimens and it took 72 to 240 hours to about 8% MC, which is recommended as the indoor in-use MC. The temperatures in the hole of the Control (UC) and HCO specimens constantly showed a higher-leveled distribution pattern than those inside wood. The vapor pressure in the hole of the UC, HCO and BR specimens was higher than that inside wood and showed difference as highest value of about 20 mbar. The surface checks of all specimens were mild and were observed in increasing order of BRC, BR, UC, VD and HCO specimens.

Background— The optimal duration of dual antiplatelet therapy (DAPT) after implantation of drug-eluting coronary stents remains undetermined. We aimed to test whether 6-month DAPT would be noninferior to 12-month DAPT after implantation of drug-eluting stents. Methods and Results— We randomly assigned 1443 patients undergoing implantation of drug-eluting stents to receive 6- or 12-month DAPT (in a 1:1 ratio). The primary end point was a target vessel failure, defined as the composite of cardiac death, myocardial infarction, or ischemia-driven target vessel revascularization at 12 months. Rates of target vessel failure at 12 months were 4.8% in the 6-month DAPT group and 4.3% in the 12-month DAPT group (the upper limit of 1-sided 95% confidence interval, 2.4%; P =0.001 for noninferiority with a predefined noninferiority margin of 4.0%). Although stent thrombosis tended to occur more frequently in the 6-month DAPT group than in the 12-month group (0.9% versus 0.1%; hazard ratio, 6.02; 95% confidence interval, 0.72–49.96; P =0.10), the risk of death or myocardial infarction did not differ in the 2 groups (2.4% versus 1.9%; hazard ratio, 1.21; 95% confidence interval, 0.60–2.47; P =0.58). In the prespecified subgroup analysis, target vessel failure occurred more frequently in the 6-month DAPT group than in the 12-month group (hazard ratio, 3.16; 95% confidence interval, 1.42–7.03; P =0.005) among diabetic patients. Conclusions— Six-month DAPT did not increase the risk of target vessel failure at 12 months after implantation of drug-eluting stents compared with 12-month DAPT. However, the noninferiority margin was wide, and the study was underpowered for death or myocardial infarction. Our results need to be confirmed in larger trials. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00698607.

Ultraviolet B (UVB) radiation on human skin induces pathophysiological processes such as oxidative stress and inflammation. In previous reports, the antioxidant effects of triphlorethol-A were shown to protect cells against hydrogen peroxide-induced cell damage and gamma ray-induced oxidative stress. In this study, the role of triphlorethol-A in protecting human keratinocytes (HaCaT) against UVB-induced cell damage was investigated. Triphlorethol-A-treated cells were irradiated with UVB (150 mJ/cm2). Triphlorethol-A decreased UVB-induced intracellular ROS and restored the activities of antioxidant enzymes decreased by UVB radiation. Triphlorethol-A decreased UVB damage to cellular components, such as lipid membrane and DNA, restored cell viability and reduced UVB-induced apoptosis by inhibiting the mitochondria-mediated caspase pathway. Triphlorethol-A also reduced the UVB-induced loss of ΔΨm and the active forms of caspase 9 and caspase 3. The anti-apoptotic effect of triphlorethol-A was found to involve the inhibition of c-Jun NH2-terminal kinase, which was induced by UVB exposure. And triphlorethol-A showed an absorptive capacity at range of UVB. These results suggest that triphlorethol-A protects human keratinocytes against UVB by enhancing the activities of the antioxidant system, inhibiting cellular damage and absorbing the UVB.

Substation Automation System is basically operating throughout communicative services among IEC 61850 based devices. So, minimum requirement in order to install the system in the substation is to verify server and client conformance. This study aims to develop IEC 61850 SA client conformance testing system for verifying the full communication conformance of the substation automation system and this paper describes the design and implementation of the testing system.

In this study, we explored whether phloroglucinol (1,3,5-trihydroxybenzene) exerts protective effects against oxidative stress–induced cytotoxicity in SH-SY5Y cells, a neuroblastoma cell line. The central nervous system is especially vulnerable to oxidative stress because the brain consumes large amounts of energy to perform its complicated functions, but contains a lower level of anti-oxidant enzymes compared with other peripheral tissues. In SH-SY5Y cultures, pretreatment with 10 μg/ml of phloroglucinol attenuates the cytotoxicity of hydrogen peroxide. In addition, when assessed with 2′,7′-dichlorofluorescein diacetate dye, the increase in reactive oxygen species (ROS) induced by hydrogen peroxide was significantly reduced by pretreatment with phloroglucinol. ROS is known to cause lipid peroxidation of the cell membranes, the carbonylation of intracellular proteins, and DNA damage, which can lead to various cellular dysfunctions and eventually cellular death. We found that pretreatment with phloroglucinol down-regulated the levels of 8- isoprostane, protein carbonylation, and 8-hydroxy deoxyguanine caused by hydrogen peroxide treatment in SH-SY5Y cells. These results indicate that phloroglucinol exerts protective effects against oxidative stress-induced cell damage in SH-SY5Y cells. Keywords:: brown algae, hydrogen peroxide, phloroglucinol, reactive oxygen species, SH-SY5Y cell

In previous reports, the antioxidant effects of eckol were shown to protect cells against hydrogen peroxide- and gamma ray-induced oxidative stress. In this study, the role of eckol in protecting human skin keratinocytes (HaCaT) against UVB-induced oxidative cell damage was investigated. Also, triphlorethol-A, one of the chemical components in Ecklonia cava, and quercetin a well known antioxidant, were compared with eckol in terms of antioxidant activity based on chemical structure. Eckol decreased UVB-induced intracellular reactive oxygen species (ROS), decreased injury to cellular components resulting from UVB-induced oxidative stress, and restored cell viability. In addition, eckol reduced UVB-induced apoptosis by inhibiting the disruption of mitochondrial membranes. These results suggest that eckol protects human keratinocytes against UVB-induced oxidative stress by scavenging ROS, thereby lessening injury to cellular components.

Agar was prepared from Gelidium amansii collected from Jeju Island, South Korea. This agar preparation has high gel strength and low sulfate content compared with G. amansii agar from Morocco. Accordingly, agarose was made from the Jeju agar through the consecutive refi ning processes of dimethyl sulfoxide (DMSO) extraction and ethylene diamine tetra acetic acid (EDTA) washing. The physicochemical properties of the resulting agarose were compared with those from agarose prepared using only DMSO extraction. Consecutive DMSO extraction and EDTA washing more strongly affected the physicochemical properties of the agarose (purifi ed agarose) compared with the use of DMSO extraction alone. These properties were similar to those of commercial agarose used for electrophore- sis. In DNA electrophoresis, the separation and movement speed of the purifi ed agarose were similar to those of the commercial agarose. In a 13 C NMR analysis, the purifi ed agarose exhibited the same carbon peak as the commercial agarose. When observed under scanning electron microscopy, the agar had an even and smooth surface without ir- regularities or pores, and the purifi ed agarose had a wide surface area with a large number of pores; the commercial agarose had an irregular surface that would allow the solvent to easily permeate. These results illustrate that the physi- cochemical properties of agarose prepared from DMSO extraction and EDTA washing were more effective than those observed after DMSO extraction alone; thus, these processes used in succession will be useful in agarose industries.

The aim of this study was to investigate the cytoprotective properties of the ethyl acetate fraction of Sargassum muticum (SME) against ultraviolet B (UVB)-induced cell damage in human keratinocytes (HaCaT cells). SME exhibited scavenging activity toward the 1,1-diphenyl-2-picrylhydrazyl radicals and hydrogen peroxide (H(2)O(2)) and UVB-induced intracellular reactive oxygen species (ROS). SME also scavenged the hydroxyl radicals generated by the Fenton reaction (FeSO(4) + H(2)O(2)), which was detected using electron spin resonance spectrometry. In addition, SME decreased the level of lipid peroxidation that was increased by UVB radiation, and restored the level of protein expression and the activities of antioxidant enzymes that were decreased by UVB radiation. Furthermore, SME reduced UVB-induced apoptosis as shown by decreased DNA fragmentation and numbers of apoptotic bodies. These results suggest that SME protects human keratinocytes against UVB-induced oxidative stress by enhancing antioxidant activity in cells, thereby inhibiting apoptosis.

Objectives The goal of this study was to compare the angiographic outcomes of everolimus-eluting stents (EES) and sirolimus-eluting stents (SES) in a head-to-head manner. Background EES have been shown to be superior to paclitaxel-eluting stents in inhibiting late loss (LL) and clinical outcome. Whether EES may provide similar angiographic and clinical outcomes compared with SES is undetermined. Methods This was a prospective, randomized, open-label, multicenter trial to demonstrate the noninferiority of EES compared with SES in preventing LL at 9 months. A total of 1,443 patients undergoing percutaneous coronary intervention were randomized 3:1 to receive EES or SES. Routine follow-up angiography was recommended at 9 months. The primary endpoint was in-segment LL at 9 months, and major secondary endpoints included in-stent LL at 9 months, target lesion failure, cardiac death, nonfatal myocardial infarction, target lesion revascularization, and stent thrombosis at 12 months. Data were managed by an independent management center, and clinical events were adjudicated by an independent adjudication committee. Results Clinical follow-up was available in 1,428 patients and angiographic follow-up in 924 patients (1,215 lesions). The primary endpoint of the study (in-segment LL at 9 months) was 0.11 ± 0.38 mm and 0.06 ± 0.36 mm for EES and SES, respectively (p for noninferiority = 0.0382). The in-stent LL was also noninferior (EES 0.19 ± 0.35 mm; SES 0.15 ± 0.34 mm; p for noninferiority = 0.0121). The incidence of clinical endpoints was not statistically different between the 2 groups, including target lesion failure (3.75% vs. 3.05%; p = 0.53) and stent thrombosis (0.37% vs. 0.83%; p = 0.38). Conclusions EES were noninferior to SES in inhibition of LL after stenting, which was corroborated by similar rates of clinical outcomes. (Efficacy of Xience/Promus Versus Cypher in Reducing Late Loss After Stenting [EXCELLENT]; NCT00698607 )

Due to the rapid development of digital technnology and informantion communication, in the IEC 61850 based substation automation system, the innovative paradigm shift is expected and also required in many substation-related jobs, especially in the device function test area Accordingly a common testing model which can simplify the complex contents of the SAS performance test performed by test engineers has been identified, that can overcome limitations of engineers' own testing knowledge and experience. Testing models and its design system for the comprehensive performance test of the Substation Automation System is developed and the result of the study is reported in this paper.

As the existing radiation scanning systems use 2-dimensional radiation scanned images, the low accuracy has been pointed out as a problem of it. This research analyzes the applicability of the stereo image processing technique to X-ray scanned images. Two 2-dimensional radiation images which have different disparity values are acquired from a newly designed stereo image acquisition system which has one additional line sensor to the conventional system. Using a matching algorithm the 3D reconstruction process which find the correspondence between the images is progressed. As the radiation image is just a density information of the scanned object, the direct application of the general stereo image processing techniques to it is inefficient. To overcome this limitation of a stereo image processing in radiation area, we reconstruct 3-D shapes of the edges of the objects. Also, we proposed a new volume based 3D reconstruction algorithm. Experimental results show the proposed new volume based reconstruction technique can provide more efficient visualization for cargo inspection. The proposed technique can be used for such objects which CT or MRI cannot inspect due to restricted scan environment.

Purpose To assess the prevalence of primary open-angle glaucoma (POAG) in the Namil-myon area in central South Korea. Design A cross-sectional, epidemiologic study in a defined population. Participants Residents aged ≥40 years in Namil-myon, a rural agricultural area in central South Korea. Methods Each subject underwent a screening that consisted of an interview and ophthalmic examinations, including visual acuity measurement, autorefraction, anterior segment evaluation by optical biometry, slit-lamp examination, Goldmann applanation tonometry, binocular optic disc evaluation, fundus photography, pachymetry, gonioscopy, and screening visual field test using frequency doubling technology. Subjects with suspected glaucoma were referred for definitive examinations. Standard automated field tests and retinal nerve fiber layer analysis using optical coherence tomography (Stratus OCT) or scanning laser polarimetry (GDx VCC) were performed. A diagnosis of glaucoma was made based on the optic disc shape, retinal nerve fiber layer appearance, perimetric results, and other ocular findings. Main Outcome Measures Prevalence of POAG, mean intraocular pressure (IOP), and mean central corneal thickness (CCT). Results Of 1928 eligible residents in the area, 1532 (79.5%) participated in this study. The estimated prevalence of POAG in the population aged ≥40 years was 3.5% (95% confidence interval [CI], 2.7%–4.3%). The prevalence of POAG with an IOP of ≤21 mmHg was 2.7% (95% CI, 2.1%–3.3%), and the prevalence of POAG with an IOP of ≥22 mmHg was 0.8% (95% CI, 0.4%–1.2%). The mean IOP for POAG eyes (16.3±4.6 mmHg) was significantly higher than nonglaucomatous eyes (13.3±2.7 mmHg; P = .001). The mean CCT of POAG eyes with an IOP of ≤21 mmHg was 528±26 μm, and that of POAG eyes with an IOP ≥22 mmHg was 531±37 μm; these values were not significantly different from that of nonglaucomatous eyes (530±31 μm; P = .943 and .996, respectively). Conclusions The prevalences of POAG and POAG with an IOP ≤21 mmHg in the Namil-myon region of central South Korea were higher than that in most previous reports worldwide, but were similar to the reported rates in black and Japanese populations. The mean IOP of POAG eyes was higher than nonglaucomatous eyes, but the mean CCTs were not different. Financial Disclosure(s) The authors have no proprietary or commercial interest in any of the materials discussed in this article.

Progression of 3T3-L1 preadipocyte differentiation is divided into early (days 0-2, D0-D2), intermediate (days 2-4, D2-D4), and late stages (day 4 onwards, D4-). In this study, we investigated the effects of fucoxanthin, isolated from the edible brown seaweed Petalonia binghamiae, on adipogenesis during the three differentiation stages of 3T3-L1 preadipocytes. When fucoxanthin was applied during the early stage of differentiation (D0-D2), it promoted 3T3-L1 adipocyte differentiation, as evidenced by increased triglyceride accumulation. At the molecular level, fucoxanthin increased protein expression of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), sterol regulatory element-binding protein 1c (SREBP1c), and aP2, and adiponectin mRNA expression, in a dose-dependent manner. However, it reduced the expression of PPARγ, C/EBPα, and SREBP1c during the intermediate (D2-D4) and late stages (D4-D7) of differentiation. It also inhibited the uptake of glucose in mature 3T3-L1 adipocytes by reducing the phosphorylation of insulin receptor substrate 1 (IRS-1). These results suggest that fucoxanthin exerts differing effects on 3T3-L1 cells of different differentiation stages and inhibits glucose uptake in mature adipocytes.

In this paper, we developed the semiconductor neutron radiation detector and the multi-purpose radiation detection technologies for the next generation military personal surveymeter. The PIN type semiconductor neutron detector and the prototype measure the neutron radiation dose upto 1,000cGy with ±20% error. It also have a good performance about the Gamma, Alpha and Beta radiation and MIL-STD-810F.Keywords : Neutron Radiation(중성자 방사선), Neutron Dose(중성자 선량), Surveymeter(방사선측정기), Dose Rate(방사선 선율)

This study examined the characteristics of radio-frequency/vacuum dried Korean red pine (Pinus denso- flora) heavy timbers with 250 × 250 mm (S), 300 × 300 mm (L) in cross section and 300 mm in diameter, and 3,600 mm in length, which were subjected to compressive loading after a kerf pretreatment. The fol- lowing results were obtained : The drying time was short and the drying rate was high in spite of the large cross section of specimens. The moisture gradient inall specimens was gentle in both longitudinal and transverse directions owing to dielectric heating. The shrinkage of the width in the direction perpendic- ular to was 21 percent ∼ 76 percent of that of the thickness of square timbers in the direction parallel to the mechanical pressure. The casehardening for all specimens was very slight because of significantly reduced ratio of the tangential to radial shrinkage of specimens and kerfing. The surface checks somewhat severely occurred although the occurrence extent of the surface checks on the kerfed specimens was slight compared withthat on the control specimen.

The characteristics of radio-frequency/vacuum drying Japanese larch boxed heart round logs with 150 mm and 210 mm in diameter and 2,500 mm in length, subjected to compressive loading, after the pretreat-ment of kerf were investigated. The results of this study were as the follows: The drying time of about 120 hours∼130 hours was needed from green to about 15 percent of moisture content. The gradient of final moisture content for all specimens was very gentle in both longitudinal and transverse directions ow-ing to dielectric heating. The surface checks seriously occurred although the occurrence extent of surface check for the kerfed specimens was slight compared with that for the control specimens because drying stress was relieved by kerf. The occurrence of surface checks for the L-specimen was more serious than that for the S-specimen. Keywords : Boxed heart round logs, Kerf treatment, Radio-frequency/vacuum drying, Surface check 1. INTRODUCTION The importance of wood as a building mate-rial and a renewable resource was increasing due to the growing concern of human health and well-being housing environment. Consequently, the gross wooden building area in Korea had largely increased in years past. The result of a recent investigation showed that both suppliers and users of wooden houses preferred the wooden house constructed traditionally with the post-beams with very large cross section, which

This paper presents shear test results for large cast-in-place anchor bolts in concrete. The tests were performed to evaluate the shear performance of large anchors, that is, anchors with diameter greater than 2 in. (50 mm) or embedment depth greater than 25 in. (635 mm), which are not addressed by ACI 318-08, Appendix D and ACI 349-06, Appendix D. The tests were also intended to investigate the safety of such anchors for use in nuclear power plants. The test results are used to assess the applicability of existing design formulas valid for smaller anchors to large anchors. Suggestions are made for incorporating the effects of deep embedment or large diameter in existing design provisions for cast-in-place anchor bolts under shear load.

Twenty compounds were isolated from the ethanol extract of Distylium racemosum branches and their inhibitory activities on tyrosinase, elastase and free radicals evaluated. The isolated compounds were identified as dibenzofurans (1–4), abscisic acid (5), 6′-O-galloylsalidroside (6), catechin derivatives (7–11), gallic acid derivatives (12–14), tyrosol (15), flavonoids (16–18), lupeol (19) and 1,2,3,6-tetragalloylglucose (20). For study of tyrosinase inhibition activities, when compared with arbutin (IC50 48.8 μg/mL), four compounds (8, 11, 13, 17) showed higher activities, with IC50 values of 4.8, 30.2, 40.5 and 37.7 μg/mL, respectively. For the elastase inhibition test, dibenzofuran 1 showed greater activity than the positive control, oleanolic acid (IC50 9.7 μg/mL), with an IC50 of 7.7 μg/mL. In the studies on DPPH radical scavenging activities, five compounds (11, 12, 13, 14, 15) showed higher activities than ascorbic acid (IC50 5.0 μg/mL), with IC50 values of 4.6, 3.9, 2.9, 3.8 and 4.7 μg/mL, respectively. Copyright © 2011 John Wiley & Sons, Ltd.

The peel of Citrus sunki is a rich source of polymethoxyflavones (PMFs). In this study, a PMF-rich fraction (PRF) was obtained from the peels of C. sunki by hot-water extraction and subsequent fractionation with n -hexane. Six PMFs and two demethylated PMFs were isolated by semi-preparative HPLC, and their structures were identified by 1 H NMR and 13 C NMR. To define the synergistic effects of PRF, the PRF and its eight individual components were assessed for antiproliferative activity using HL-60 cells. The PRF showed greater growth inhibitory activity ( IC 50 value = 25.14 μg/ml), compared with its individual components. Flow cytometric analysis confirmed that the PRF significantly increased the percentage of sub-G 1 cells (30.1% at 25 μg/ml). Our study provides an efficient method for preparing a PRF for use as a functional food ingredient.

The toxicity of formaldehyde (HCHO) has been attributed to its ability to form adducts with DNA and proteins. Triphlorethol-A, derived from Ecklonia cava, was reported to exert a cytoprotective effect against oxidative stress damage via an antioxidant mechanism. The aim of this study was to examine the mechanisms underlying the triphlorethol-A ability to protect Chinese hamster lung fibroblast (V79-4) cells against HCHO-induced damage. Triphlorethol-A significantly decreased the HCHO-induced intracellular reactive oxygen species (ROS) production. Triphlorethol-A prevented increased cell damage induced by HCHO via inhibition of mitochondria-mediated caspase-dependent apoptosis pathway. Triphlorethol-A diminished HCHO-induced mitochondrial dysfunction, including loss of mitochondrial membrane action potential (Δψ) and adenosine triphosphate (ATP) depletion. Furthermore, the anti-apoptotic effect of triphlorethol-A was exerted through inhibition of c-Jun NH(2)-terminal kinase (JNK), which was enhanced by HCHO. Our data indicate that triphlorethol-A exerts a cytoprotective effect in V79-4 cells against HCHO-induced oxidative stress by inhibiting the mitochondria-mediated caspase-dependent apoptotic pathway.

Wood is widely used as a housing material because of its environmental superiority, good mechanical properties, fine appearance, and high thermal insulation properties. However, wood is a sound reflecting material with a relatively low sound absorption capability. It is recognized that the sound absorption capability of wood is influenced by air permeability that varies by the sound incident surface structure. Wood is a porous material which has numerous cylindrical pores in the fiber direction. However, the permeability of wood is relatively low because there are very few continuous pores in wood. The pores in wood are classified into three types: through, blind, and closed. Among these pores, only the through pore has continuous vessel elements that readily permit fluid flow. Furthermore, the formation of pit–aspirations in softwoods or tylosis in hardwoods restricts the air or liquid flow in wood. Improving the permeability of wood has been an interest of many wood researchers because highly permeable solid wood can be treated easily by a functional treatment that allows the good dimensional stability, fire proofing, and other traits. It is generally recognized that wood treatability increases with permeability. Several treatments, such as steaming, extraction with solvents, and degradation with enzymes or microorganisms, have been attempted to increase the permeability of wood. However these treatments did not have a sufficient effect on increasing permeability, and a useful method has not yet been developed. In a previous paper, Kang et al. (2008 a) reported that the delignification treatment by Wise’s method improved wood permeability in the fiber direction, and that the sound absorption capability on the cross sectional surface of Larix kaemferi increased, as compared with the control wood. Also, it was found that the sound absorption capability of a mushroom bed log of Mongolian oak degraded by fungus over four years was 2–3 times higher than that of control wood (Kang et al., 2008 b). On the other hand, steam explosion is used in the field of pulp and fiberboard manufacturing or the wood– based biomass industry and is exposure to violent pressure and temperature changes via steam. For this treatment, the target material is mounted in a closed chamber, and then superheated steam is introduced from a boiler. The superheated steam heats the chamber and target material to a high temperature and pressure, which is maintained for a moment and then discharged abruptly by a blasting device. By this process, high–pressure Changes in Permeability and Sound Absorption Capability of Yellow Poplar Wood by Steam Explosion Treatment

The chiral dinuclear tetraazadiphenol macrocyclic copper(II) complexes [Cu2([20]-DCHDC)(La)2] {H2[20]-DCHDC = 14,29-dimethyl-3,10,18,25-tetraazapentacyclo-[25,3,1,04,9,112,16,019,24]ditriacontane-2,10,12,14,16(32),17,27(31),28,30-decane-31,32-diol; La = N3− (II), NCS− (IV) or S2O32− (V)} has been synthesized and structurally characterized by elemental analysis, conductance, electronic and IR spectra as well as FAB-MS method. Crystal structure of [Cu2([20]-DCHDC)(N3)2]·2CH3OH (III) determined by X-ray crystallography reveal the two square pyramidal copper centers bridged by the two phenoxide oxygen atoms, with large Cu–O–Cu angles {100.88(10)°}.

This paper presents a 3-D visualization technique using stereo radioactive images to provide efficient inspection of fast moving cargo objects. The proposed technique can be used for such objects which CT or MRI cannot inspect due to restricted scan environment. Stereo radioactive images are acquired from a specially designed equipment which consists of a X-ray source, linear radioactive sensors, and a moving stage. Two radioactive sensors are installed so that rectified stereo X-ray images of objects are acquired. Using the stereo X-ray images, we run a matching algorithm to find the correspondences between the images and reconstruct 3-D shapes of real objects. The objects are put in a parallelepiped box to simulate cargo inspection. Three real objects are tested and reconstructed. Due to the inherent ambiguity in the stereo X-ray images, we reconstruct 3-D shapes of the edges of the objects. The experimental results show the proposed technique can provide efficient visualization for cargo inspection.

In this paper, we presents a sensor calibration technique using stereo X-ray images to provide efficient inspection of fast moving cargo objects. Stereo X-ray scanned images are acquired from a specially designed equipment which consists of a X-ray source, dual-linear array detector, and a conveyor system. Dual detector is installed so that rectified stereo X-ray images of objects are acquired. Using the stereo X-ray images, we carry out a sensor calibration to find the correspondences between the images and reconstruct 3-D shapes of real objects. Using the Image acquired from the stereo detectors with varying distances, we calculated the GCP(ground control point)of the image. And we figure out the error by comparing calculated GCP and GCP of the real object. The experimental results show the proposed technique can enhance the accuracy of stereo matching and give more efficient visualization for cargo inspection image.

Purpose: To evaluate the characteristic multidetector-row computed tomography (MDCT) findings of anomalous double right coronary arteries (RCAs), an extremely rare variant. Methods: During a 3-year period, 2569 patients with chest pain underwent MDCT coronary angiography. Five patients (0.2%) with anomalous double RCAs were found (mean age, 66 years; range, 43-81 years; 3 women). The location and number of orifice, anatomical distribution of the RCA and its branches, and presence of atherosclerosis were analyzed. Results: All the 5 cases of double RCAs originated from the right sinus of Valsalva and could be classified into 3 types according to the characteristics. One patient (type 1) had a double RCA arising from 2 separated orifices in the right sinus of Valsalva; another patient (type 2) had 2 separate RCAs originating from a common orifice in the sinus of Valsalva; the other 3 patients with double RCAs (type 3) had a common main RCA in the sinus of Valsalva with a proximal bifurcation, like the usual left coronary arterial system. Conclusions: Our data showed that although a double RCA is a rare anomaly, it is easily detected using MDCT and can be classified into 3 types.

Substation Automation System is basically operating throughout communicative services among IEC 61850 based devices. So, minimum requirement in order to install the system in the substation is to verify server and client conformance of IEDs and HMIs according to the IEC 61850 standard. Even though UCA IUG issued IEC 61850 conformance test procedures for both the server and the client, Much of the test is limited to IEDs as server and there is no client-only testing tool except KEMA server test tool sets. this study aims to develop IEC 61850 client testing system for verifying the full communication conformance of the substation automation system and this paper describes the design and implementation of the testing system.

The goal of this research was to measure extremely high doses of ionizing and non-ionizing radiation separately near a commercial nuclear reactor. Specially designed p-MOSFETs were used for detecting ionizing radiation. Custom PIN diode dosimeters were developed in-house for measuring high dose of non-ionizing radiation. The two semiconductor dosimeters successfully measured ionizing and non-ionizing radiation separately in a mixed-field high-radiation environment. The neutron sensitivity of the developed dosimeter was 14.63 mV/cGy, or three times higher than that of the conventional ones. This paper describes the development, calibration, and application of the diode dosimeter.

This paper presents the guideline for enhancing the reliability and availability of SAS with IEC 61850 based IEDs in real power system. The IEC 61850 standard communication networks and systems allow utilities to consider new designs for substations applicable both new substation and refurbishments. The existing solutions are based on hardwired interface between the primary substation equipment and the secondary protection, monitoring, control and recording devices. All over the world, lots of projects at different stages of realization have been reported during the last year leading to a rapid maturation of the associated technologies. At present, IEC 61850 is becoming a popular communication standard for the substation automation system.