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1,226 results on '"Nakamura, Yoshimasa"'

151. Auraptene, an Alkyloxylated Coumarin from Citrus natsudaidai HAYATA, Inhibits Mouse Skin Tumor Promotion and Rat Colonic Aberrant Crypt Foci Formation

Author

Murakami, Akira, primary, Kuki, Wataru, additional, Takahashi, Yasuo, additional, Yonei, Hiroshi, additional, Tanaka, Takuji, additional, Makita, Hiroki, additional, Wada, Keiji, additional, Ueda, Naomi, additional, Haga, Masanobu, additional, Nakamura, Yoshimasa, additional, Ohto, Yoshimi, additional, Kim, Oe Kyung, additional, Ohigashi, Hajime, additional, and Koshimizu, Koichi, additional

Published
1998
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153. Guard Cell Salicylic Acid Signaling Is Integrated into Abscisic Acid Signaling via the Ca2+/CPK-Dependent Pathway1[OPEN]

Author

Prodhan, Md. Yeasin, Munemasa, Shintaro, Nahar, Mst. Nur-E-Nazmun, Nakamura, Yoshimasa, and Murata, Yoshiyuki

Subjects
Plant Leaves, Plant Growth Regulators, Arabidopsis Proteins, Calcium-Calmodulin-Dependent Protein Kinases, Mutation, Plant Stomata, Arabidopsis, Calcium, Articles, Reactive Oxygen Species, Salicylic Acid, Abscisic Acid, Signal Transduction
Abstract

The phenolic hormone salicylic acid (SA) induces stomatal closure. It has been suggested that SA signaling is integrated with abscisic acid (ABA) signaling in guard cells, but the integration mechanism remains unclear. The Ca

Published
2018

157. The Golgin Protein Giantin Regulates Interconnections Between Golgi Stacks

Author

Satoh, Ayano, primary, Hayashi-Nishino, Mitsuko, additional, Shakuno, Takuto, additional, Masuda, Junko, additional, Koreishi, Mayuko, additional, Murakami, Runa, additional, Nakamura, Yoshimasa, additional, Nakamura, Toshiyuki, additional, Abe-Kanoh, Naomi, additional, Honjo, Yasuko, additional, Malsam, Joerg, additional, Yu, Sidney, additional, and Nishino, Kunihiko, additional

Published
2019
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160. Reactive Carbonyl Species Function as Signal Mediators Downstream of H2O2 Production and Regulate [Ca2+]cyt Elevation in ABA Signal Pathway in Arabidopsis Guard Cells

Author

Islam, Md. Moshiul, primary, Ye, Wenxiu, additional, Matsushima, Daiki, additional, Rhaman, Mohammad Saidur, additional, Munemasa, Shintaro, additional, Okuma, Eiji, additional, Nakamura, Yoshimasa, additional, Biswas, Md. Sanaullah, additional, Mano, Jun’ichi, additional, and Murata, Yoshiyuki, additional

Published
2019
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162. Neither glutamate nor alanine but arginine sensitizes BY-2 cells to arsenate

Author

Nahar, Nur-E-Nazmun, Prodhan, Md Yeasin, Mimata, Yoshiharu, Yonezawa, Anna, Nakamura, Toshiyuki, Nakamura, Yoshimasa, Munemasa, Shintaro, and Murata, Yoshiyuki

Abstract

Arsenic is toxic for plants. Our previous results showed that the application of proline enhanced the sensitivity of tobacco BY-2 cells to arsenate. In order to clarify the enhancement mechanism, we investigated the effects of other amino acids on the arsenate-stressed BY-2 cells. Glutamate at up to 10 m mdid not affect the cell growth in the absence or presence of arsenate. Arginine at up to 10 m mdid not affect the growth in the absence of arsenate but arginine at 10 m menhanced the inhibition of the cell growth by arsenate. Alanine at up to 10 m mdid not affect the cell growth under nonstressed condition but alanine at 10 m msignificantly improved the cell growth under arsenate stress. These results suggest that alanine mitigates arsenate stress in BY-2 cells and that arginine like proline enhances the sensitivity of BY-2 cells to arsenate.Graphical AbstractA hypothetical flow diagram of arsenate-inhibited catabolic process of P5C-based amino acids.

Published
2022
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165. Phenethyl isothiocyanate activates leptin signaling and decreases food intake

Author

Yagi, Miho, Nakatsuji, Yukiko, Maeda, Ayumi, Ota, Hiroki, Kamikubo, Ryosuke, Miyoshi, Noriyuki, Nakamura, Yoshimasa, Akagawa, Mitsugu, Yagi, Miho, Nakatsuji, Yukiko, Maeda, Ayumi, Ota, Hiroki, Kamikubo, Ryosuke, Miyoshi, Noriyuki, Nakamura, Yoshimasa, and Akagawa, Mitsugu

Abstract

Obesity, a principal risk factor for the development of diabetes mellitus, heart disease, and hypertension, is a growing and serious health problem all over the world. Leptin is a weight-reducing hormone produced by adipose tissue, which decreases food intake via hypothalamic leptin receptors (Ob-Rb) and the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. Protein tyrosine phosphatase 1B (PTP1B) negatively regulates leptin signaling by dephosphorylating JAK2, and the increased activity of PTP1B is implicated in the pathogenesis of obesity. Hence, inhibition of PTP1B may help prevent and reduce obesity. In this study, we revealed that phenethyl isothiocyanate (PEITC), a naturally occurring isothiocyanate in certain cruciferous vegetables, potently inhibits recombinant PTP1B by binding to the reactive cysteinyl thiol. Moreover, we found that PEITC causes the ligand-independent phosphorylation of Ob-Rb, JAK2, and STAT3 by inhibiting cellular PTP1B in differentiated human SH-SY5Y neuronal cells. PEITC treatment also induced nuclear accumulation of phosphorylated STAT3, resulting in enhanced anorexigenic POMC expression and suppressed orexigenic NPY/AGRP expression. We demonstrated that oral administration of PEITC to mice significantly reduces food intake, and stimulates hypothalamic leptin signaling. Our results suggest that PEITC might help prevent and improve obesity.

Published
2018

167. Stomatal response to isothiocyanates in Arabidopsis thaliana.

Author

Afrin, Sonya, Okuma, Eiji, Tahjib-Ul-Arif, Md, Jahan, Md Sarwar, Nakamura, Toshiyuki, Nakamura, Yoshimasa, Munemasa, Shintaro, and Murata, Yoshiyuki

Subjects
ISOTHIOCYANATES, REACTIVE oxygen species, FUNCTIONAL groups, GLUTATHIONE
Abstract

Allyl isothiocyanate (AITC) induces stomatal closure accompanied by reactive oxygen species (ROS) production and glutathione (GSH) depletion in Arabidopsis thaliana. In this study, stomatal responses to three other isothiocyanates (ITCs), benzyl isothiocyanate (BITC), sulforaphane (SFN), and phenethyl isothiocyanate (PEITC), were investigated in A. thaliana. All these ITCs significantly induced stomatal closure, where PEITC and BITC were most effective. The selected ITCs also induced ROS accumulation, cytosolic alkalization, and GSH depletion in guard cells. Moreover, all ITCs increased the frequency of cytosolic free calcium ([Ca2+]cyt) spikes (transient elevation), while PEITC and BITC showed the highest frequency. There was a strong positive correlation between the number of [Ca2+]cyt spikes per guard cell and the decrease in stomatal aperture. Both cytosolic alkalization and GSH content have a positive correlation with the decrease in stomatal aperture, but ROS production did not have a significant correlation with the decrease in stomatal apertures. These results indicate that the molecules with a functional ITC group induce stomatal closure that is accompanied by GSH depletion, cytosolic alkalization, [Ca2+]cyt spikes, and ROS production, and that the former three cellular events, rather than ROS production, are highly correlated with the decrease in stomatal aperture. [ABSTRACT FROM AUTHOR]

Published
2020
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168. Exogenous proline enhances antioxidant enzyme activities but does not mitigate growth inhibition by selenate stress in tobacco BY-2 cells.

Author

Khatun, Mousumi, Matsushima, Daiki, Rhaman, Mohammad Saidur, Okuma, Eiji, Nakamura, Toshiyuki, Nakamura, Yoshimasa, Munemasa, Shintaro, and Murata, Yoshiyuki

Subjects
GLUTATHIONE peroxidase, REACTIVE oxygen species, PROLINE, ENZYMES, CELL death inhibition, CATALASE, VITAMIN C, GLUTATHIONE
Abstract

Selenium (Se) causes oxidative damage to plants. Proline is accumulated as a compatible solute in plants under stress conditions and mitigates stresses. Selenate at 250 µM increased cell death and inhibited the growth of tobacco BY-2 cells while exogenous proline at 10 mM did not mitigate the inhibition by selenate. Selenate increased accumulation of Se and ROS and activities of antioxidant enzymes but not lipid peroxidation in the BY-2 cells. Proline increased Se accumulation and antioxidant enzyme activities but not either ROS accumulation or lipid peroxidation in the selenate-stressed cells. Glutathione (GSH) rather than ascorbic acid (AsA) mitigated the growth inhibition although both reduced the accumulation of ROS induced by selenate. These results indicate that proline increases both antioxidant enzyme activities and Se accumulation, which overall fails to ameliorate the growth inhibition by selenate and that the growth inhibition is not accounted for only by ROS accumulation. Abbreviations: APX: ascorbate peroxidase; AsA: ascorbic acid; BY-2: Bright Yellow-2; CAT: catalase; DAI: days after inoculation; DW: dry weight; FW: fresh weight; GSH: glutathione; ROS: reactive oxygen species Exogenous application of proline does not mitigate the growth inhibition by selenate and the growth inhibition by selenate is not accounted for by ROS accumulation. [ABSTRACT FROM AUTHOR]

Published
2020
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169. Inhibition of light-induced stomatal opening by allyl isothiocyanate does not require guard cell cytosolic Ca2+ signaling.

Author

Ye, Wenxiu, Ando, Eigo, Rhaman, Mohammad Saidur, Tahjib-Ul-Arif, Md, Okuma, Eiji, Nakamura, Yoshimasa, Kinoshita, Toshinori, and Murata, Yoshiyuki

Subjects
TRP channels, POTASSIUM channels, CELL membranes, NICOTINAMIDE, BRASSICALES, ISOTHIOCYANATES, CALCIUM channels
Abstract

The glucosinolate–myrosinase system is a well-known defense system that has been shown to induce stomatal closure in Brassicales. Isothiocyanates are highly reactive hydrolysates of glucosinolates, and an isothiocyanate, allyl isothiocyanate (AITC), induces stomatal closure accompanied by elevation of free cytosolic Ca2+ concentration ([Ca2+]cyt) in Arabidopsis. It remains unknown whether AITC inhibits light-induced stomatal opening. This study investigated the role of Ca2+ in AITC-induced stomatal closure and inhibition of light-induced stomatal opening. AITC induced stomatal closure and inhibited light-induced stomatal opening in a dose-dependent manner. A Ca2+ channel inhibitor, La3+, a Ca2+chelator, EGTA, and an inhibitor of Ca2+ release from internal stores, nicotinamide, inhibited AITC-induced [Ca2+]cyt elevation and stomatal closure, but did not affect inhibition of light-induced stomatal opening. AITC activated non-selective Ca2+-permeable cation channels and inhibited inward-rectifying K+ (K+in) channels in a Ca2+-independent manner. AITC also inhibited stomatal opening induced by fusicoccin, a plasma membrane H+-ATPase activator, but had no significant effect on fusicoccin-induced phosphorylation of the penultimate threonine of H+-ATPase. Taken together, these results suggest that AITC induces Ca2+ influx and Ca2+ release to elevate [Ca2+]cyt, which is essential for AITC-induced stomatal closure but not for inhibition of K+in channels and light-induced stomatal opening. [ABSTRACT FROM AUTHOR]

Published
2020
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183. Subtraction-free recurrence relations for lower bounds of the minimal singular value of an upper bidiagonal matrix

Author

Yamashita, Takumi, Kimura, Kinji, and Nakamura, Yoshimasa

Subjects
subtraction-free recurrence relations, lower bound of the minimal singular value
Abstract

On an N × N upper bidiagonal matrix B, where all the diagonals and the upper subdiagonals are positive, and its transpose BT, it is shown in the recent paper [4] that quantities JM(B) ≡ Tr(((BTB)M)-1) (M = 1, 2, . . . ) gives a sequence of lower bounds θM(B) of the minimal singular value of B through θM(B) ≡ (JM(B))-1/(2M). In [4], simple recurrence relations for computing all the diagonals of ((BTB)M)-1 and ((BBT )M)-1 are also presented. The square of θM(B) can be used as a shift of origin in numerical algorithms for computing all the singular values of B. In this paper, new recurrence relations which have advantages over the old ones in [4] are presented. The new recurrence relations consist of only addition, multiplication and division among positive quantities. Namely, they are subtraction-free. This property excludes any possibility of cancellation error in numerical computation of the traces JM(B). Computational cost for the trace JM(B) (M = 1, 2, . . . ) and efficient implementations for J2(B) and J3(B) are also discussed.

Published
2012

184. On some properties of a discrete hungry Lotka-Volterra system of multiplicative type

Author

Hama, Yosuke, Fukuda, Akiko, Yamamoto, Yusaku, Iwasaki, Masashi, Ishiwata, Emiko, and Nakamura, Yoshimasa

Subjects
discrete hungry, LR transformation, Backlund transformation, asymptotic convergence, Toda equation, discrete hungry Lotka-Volterra system
Abstract

Two kinds of discrete hungry Lotka-Volterra systems (dhLV) are known as discretizations of the additive type hungry Lotka-Volterra system and the multiplicative one. By associating the dhLV of additive type (dhLVI) and the discrete hungry Toda equation (dhToda) with LR transformations, some of the authors give a Bäcklund transformation between these two systems. In this paper, from the dhLV of multiplicative type (dhLVII), we first derive the qd-type dhLVII. Through finding the positivity of the qd-type dhLVII and the LR transformation associated with the dhLVII, we present Bäcklund transformations among the dhLVI, the dhLVII and the dhToda. Moreover, by using one of the Bäcklund transformations, we show asymptotic convergence of the qd-type dhLVII.

Published
2012

196. Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes

Author

Okuda, Yu, primary, Kushida, Masahiko, additional, Sumida, Kayo, additional, Nagahori, Hirohisa, additional, Nakamura, Yoshimasa, additional, Higuchi, Hashihiro, additional, Kawamura, Satoshi, additional, Lake, Brian G., additional, Cohen, Samuel M., additional, and Yamada, Tomoya, additional

Published
2017
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200. Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

Author

Okuda, Yu, primary, Kushida, Masahiko, additional, Kikumoto, Hiroko, additional, Nakamura, Yoshimasa, additional, Higuchi, Hashihiro, additional, Kawamura, Satoshi, additional, Cohen, Samuel M., additional, Lake, Brian G., additional, and Yamada, Tomoya, additional

Published
2017
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