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161. Annexin A5 involvement in bone overgrowth at the enthesis

Author

Shimada, Akemi, Ideno, Hisashi, Arai, Yoshinori, Komatsu, Koichiro, Wada, Satoshi, Yamashita, Teruhito, Amizuka, Norio, Pöschl, Ernst, Brachvogel, Bent, Nakamura, Yoshiki, Nakashima, Kazuhisa, Mizukami, Hiroaki, Ezura, Yoichi, and Nifuji, Akira

Abstract

Little is known about the molecular mechanisms of enthesis formation in mature animals. Here, we report that annexin A5 (Anxa5) plays a critical role in the regulation of bone ridge outgrowth at the entheses. We found that Anxa5 is highly expressed in the entheses of postnatal and adult mice. In Anxa5‐deficient (Anxa5–/–) mice, the sizes of bone ridge outgrowths at the entheses of the tibiae and femur were increased after 7 weeks of age. Bone overgrowth was not observed at the fibrous enthesis where the fibrocartilage layer does not exist. More ALP‐expressing cells were observed in the fibrocartilage layer in Anxa5–/– mice than in wild‐type (WT) mice. Calcein and Alizarin Red double labeling revealed more mineralized areas in Anxa5–/– mice than WT mice. To examine the effects of mechanical forces, we performed tenotomy in which transmission of contractile forces by the tibial muscle was impaired by surgical muscle release. In tenotomized mice, bone overgrowth at the enthesis in Anxa5–/– mice was decreased to a level comparable to that in WT mice at 8 weeks after the operation. The tail‐suspended mice also showed a decrease in bone overgrowth to similar levels in Anxa5–/– and WT mice at 8 weeks after hindlimb unloading. These results suggest that bone overgrowth at the enthesis requires mechanical forces. We further examined effects of AnxaA5 gene knockdown (KD) in primary cultures of osteoblasts, chondrocytes, and tenocytes in vitro. AnxaA5 KD increased ALP expression in tenocytes and chondrocytes but not in osteoblasts, suggesting that increased ALP activity in the fibrocartilaginous tissue in AnxaA5 KO mice is directly caused by Anxa5 deletion in tenocytes or fibrocartilage cells. These data indicate that Anxa5 prevents bone overgrowth at the enthesis, whose formation is mediated through mechanical forces and modulating expression of mineralization regulators.

Published
2018

165. Role of β-adrenergic signaling in masseter muscle

Author

Ito, Aiko, primary, Ohnuki, Yoshiki, additional, Suita, Kenji, additional, Ishikawa, Misao, additional, Mototani, Yasumasa, additional, Shiozawa, Kouichi, additional, Kawamura, Naoya, additional, Yagisawa, Yuka, additional, Nariyama, Megumi, additional, Umeki, Daisuke, additional, Nakamura, Yoshiki, additional, and Okumura, Satoshi, additional

Published
2019
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173. Influence of pre-drilling diameter on the stability of orthodontic anchoring screws in the mid-palatal area.

Author

Yasuki Uchida, Yasuhiro Namura, Mizuki Inaba, Ayaka Osada, Tasku Charleston-Coad, Yoshiki Nakamura, Mitsuru Motoyoshi, Uchida, Yasuki, Namura, Yasuhiro, Inaba, Mizuki, Osada, Ayaka, Charleston-Coad, Tasku, Nakamura, Yoshiki, and Motoyoshi, Mitsuru

Subjects
MOLARS, SCREWS, DIAMETER, CORRECTIVE orthodontics, ANCHORS, MAXILLARY expansion, DENTAL implants, TORQUE, ORTHODONTICS, BONE screws, PALATE
Abstract

Purpose: The aim of this study was to investigate the stability of orthodontic anchor screws (OASs) in the mid-palatal area according to pre-drilling diameter.Methods: The success rate of 161 OASs (83 patients, φ2.0 mm, 6.0 mm in length) placed in a corresponding area to the mesial and distal borders of the first molar (mesial zone and distal zone) was assessed according to placement location and pre-drilling diameter (1.2 and 1.5 mm). Placement torque values from 73 OASs with a pre-drilling diameter of 1.2 mm were compared between success and failure groups.Results: The success rates of OASs pre-drilled with φ1.2 and 1.5 mm were 94.5% and 83.0%, respectively (P < 0.05); corresponding rates in the mesial zone were 100.0% and 77.3% (P < 0.005), and those in the distal zone were 89.2% and 88.6%, respectively. Placement torques of OASs predrilled with φ1.2 mm in the success and failure groups were 25.9 and 19.2 N·cm, respectively (P < 0.05).Conclusion: A smaller pre-drilling diameter was associated with a higher success rate of OASs in the mid-palatal area, especially in the mesial zone. When pre-drilling diameter of 1.2 mm was used for φ2.0 mm OAS, greater placement torque was indicative of greater OAS stability. [ABSTRACT FROM AUTHOR]

Published
2021
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174. Low-intensity pulsed ultrasound enhances the rate of lateral tooth movement and compensatory bone formation in rats

Author

Arai, Chihiro, Kawai, Nobuhiko, Nomura, Yoshiaki, Tsuge, Atsushi, Nakamura, Yoshiki, Tanaka, Eiji, Arai, Chihiro, Kawai, Nobuhiko, Nomura, Yoshiaki, Tsuge, Atsushi, Nakamura, Yoshiki, and Tanaka, Eiji

Abstract

Introduction: Because mechanical stimulation of the periodontal ligament (PDL) by low-intensity pulsed ultrasound (LIPUS) has been shown to increase the speed of bone remodeling, the aim of this study was to examine the effects of LIPUS stimulation on the rate of tooth movement and bone remodeling during lateral tooth movement. Methods: Twelve-week-old Wistar rats were divided into two groups. The LIPUS group received experimental tooth movement with LIPUS stimulation, and the tooth movement (TM) group had experimental tooth movement without LIPUS. For the LIPUS and TM groups, the upper right first molars were moved labially with fixed appliances. LIPUS exposure was placed in the region corresponding to the right maxillary first molar. Three days after tooth movement, tartrate-resistant acid phosphatase (TRAP) was examined. Fourteen days after tooth movement, the intermolar width, bone mineral content (BMC), and bone volume fraction (BV/TV) were examined by micro computed tomography (micro-CT), and newly formed bone was measured histomorphometrically. Results: The number of TRAP-positive cells at the compressed region was obviously greater in the LIPUS group. The intermolar width was significantly greater in the LIPUS group than in the TM group. The alveolar bone around the maxillary first molar showed no differences in BMC or BV/TV between the LIPUS and TM groups. The LIPUS group exhibited a significantly greater amount of newly formed alveolar bone than the TM group. Conclusions: The present study provides evidence of the beneficial effects of LIPUS on the lateral tooth movement.

Published
2019

191. Single Local Injection of Epigallocatechin Gallate-Modified Gelatin Attenuates Bone Resorption and Orthodontic Tooth Movement in Mice

Author

Katsumata, Yuta, primary, Kanzaki, Hiroyuki, additional, Honda, Yoshitomo, additional, Tanaka, Tomonari, additional, Yamaguchi, Yuuki, additional, Itohiya, Kanako, additional, Fukaya, Sari, additional, Miyamoto, Yutaka, additional, Narimiya, Tsuyoshi, additional, Wada, Satoshi, additional, and Nakamura, Yoshiki, additional

Published
2018
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193. Author's response

Author

Fukaya, Sari, primary, Kanzaki, Hiroyuki, additional, Miyamoto, Yutaka, additional, Yamaguchi, Yuki, additional, and Nakamura, Yoshiki, additional

Published
2018
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195. Annexin A5 Involvement in Bone Overgrowth at the Enthesis

Author

Shimada, Akemi, primary, Ideno, Hisashi, additional, Arai, Yoshinori, additional, Komatsu, Koichiro, additional, Wada, Satoshi, additional, Yamashita, Teruhito, additional, Amizuka, Norio, additional, Pöschl, Ernst, additional, Brachvogel, Bent, additional, Nakamura, Yoshiki, additional, Nakashima, Kazuhisa, additional, Mizukami, Hiroaki, additional, Ezura, Yoichi, additional, and Nifuji, Akira, additional

Published
2018
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198. Discovery of [cis-3-({(5R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Author

Kono, Mitsunori, primary, Ochida, Atsuko, additional, Oda, Tsuneo, additional, Imada, Takashi, additional, Banno, Yoshihiro, additional, Taya, Naohiro, additional, Masada, Shinichi, additional, Kawamoto, Tetsuji, additional, Yonemori, Kazuko, additional, Nara, Yoshi, additional, Fukase, Yoshiyuki, additional, Yukawa, Tomoya, additional, Tokuhara, Hidekazu, additional, Skene, Robert, additional, Sang, Bi-Ching, additional, Hoffman, Isaac D., additional, Snell, Gyorgy P., additional, Uga, Keiko, additional, Shibata, Akira, additional, Igaki, Keiko, additional, Nakamura, Yoshiki, additional, Nakagawa, Hideyuki, additional, Tsuchimori, Noboru, additional, Yamasaki, Masashi, additional, Shirai, Junya, additional, and Yamamoto, Satoshi, additional

Published
2018
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199. Solvent effect on single-chain collapse of poly(methyl methacrylate) in tert-butyl alcohol.

Author

Nakamura, Yoshiki, Sasaki, Naoki, and Nakata, Mitsuo

Subjects
*METHYL methacrylate, *BUTANOL, *LIGHT scattering
Abstract

Kinetic and static properties of the coil-globule transition of poly(methyl methacrylate) (PMMA) in pure tert-butyl alcohol were determined by static light scattering and compared with those of PMMA in the mixed solvent tert-butyl alcohol+water(2.5 vol%) in order to examine the effect of water on the chain collapse. The measurements were carried out for the molecular weight M × 10[sup -6] = 4.1 and 12.2 in the concentration range of 0.6 × 10[sup -4]-2.6×10[sup -4] g/cm³, and the mean-square radius of gyration 〈s²〉 was determined as a function of the time after an abrupt decrease of temperature. PMMA chains collapsed to equilibrium globules within 90 min after quenching for M=1.22 × 10[sup 7] and within 30 min for M=4.1×10[sup 6]. Chain aggregation due to phase separation became noticeable after the collapse of the chain because of an increase of observed molecular weight. For PMMA in the mixed solvent tert-butyl alcohol+water(2.5 vol%), the chain collapse process has been observed for periods from hours to weeks depending on the molecular weight and temperature, and the chain aggregation was negligibly small in the chain collapse process. The expansion factor α²=〈s²〉/〈S²〉[sub 0] obtained for fully collapsed chains in pure tert-butyl alcohol was represented by the theoretical prediction α³-α-C(α[sup -3]-1)=B(1-θ/T)M[sup 1/2] with the coefficients of B=0.0179 and C=0.054. For PMMA in the mixed solvent, the coil-globule transition curve has been expressed by the same equation with B=0.0164 and C=0.049, close to the above values. The small amount of water in the mixed solvent caused a drastic slowdown in the chain-collapse rate but had little effect on the coil-globule transition curve. [ABSTRACT FROM AUTHOR]

Published
2003
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