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151. V[O.sub.2peak] prediction and exercise prescription for pregnant women

Author

Mottola, Michelle F., Davenport, Margie H., Brun, Chantale R., Inglis, Stuart D., Charlesworth, Sarah, and Sopper, Maggie M.

Subjects
Pregnant women -- Health aspects, Exercise -- Health aspects, Exercise -- Methods, Heart beat -- Health aspects, Health, Sports and fitness
Abstract

A study was designed to develop and validate a prediction equation for peak oxygen consumption (V[O.sub.2peak]) using a progressive treadmill test and to refine the current target HR exercise guidelines for pregnancy. The defined target HR zones based on age and the appropriate fitness levels could be used for exercise prescription in healthy pregnant women.

Published
2006

152. Aquatic Activities During Pregnancy Prevent Excessive Maternal Weight Gain and Preserve Birth Weight: A Randomized Clinical Trial.

Author

Bacchi, Mariano, Mottola, Michelle F., Perales, Maria, Refoyo, Ignacio, and Barakat, Ruben

Subjects
*AQUATIC exercises, *PREGNANCY, *WEIGHT gain in pregnancy, *BIRTH weight, *CLINICAL trials, *COMPARATIVE studies, *EXERCISE, *HEALTH behavior, *HEALTH promotion, *RESEARCH methodology, *EVALUATION of medical care, *MEDICAL cooperation, *RESEARCH, *STATISTICAL sampling, *EVALUATION research, *BODY mass index, *RANDOMIZED controlled trials, PREVENTION of pregnancy complications
Abstract

Purpose: The aim of the present study was to examine the influence of a supervised and regular program of aquatic activities throughout gestation on maternal weight gain and birth weight.Design: A randomized clinical trial.Setting: Instituto de Obstetricia, Ginecología y Fertilidad Ghisoni (Buenos Aires, Argentina).Participants: One hundred eleven pregnant women were analyzed (31.6 ± 3.8 years). All women had uncomplicated and singleton pregnancies; 49 were allocated to the exercise group (EG) and 62 to the control group (CG).Intervention: The intervention program consisted of 3 weekly sessions of aerobic and resistance aquatic activities from weeks 10 to 12 until weeks 38 to 39 of gestation.Measures: Maternal weight gain, birth weight, and other maternal and fetal outcomes were obtained by hospital records.Analysis: Student unpaired t test and χ2 test were used; P values ≤.05 indicated statistical significance. Cohen's d was used to determinate the effect size.Results: There was a higher percentage of women with excessive maternal weight gain in the CG (45.2%; n = 28) than in the EG (24.5%; n = 12; odds ratio = 0.39; 95% confidence interval: 0.17-0.89; P = .02). Birth weight and other pregnancy outcomes showed no differences between groups.Conclusion: Three weekly sessions of water activities throughout pregnancy prevents excessive maternal weight gain and preserves birth weight.Trial Registration: The clinicaltrial.gov identifier: NCT 02602106. [ABSTRACT FROM AUTHOR]

Published
2018
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153. Preventing Long-Term Risk of Obesity for Two Generations: Prenatal Physical Activity Is Part of the Puzzle

Author

Ruchat, Stephanie-May and Mottola, Michelle F.

Subjects
Article Subject
Abstract

Background. The period surrounding pregnancy has been identified as a risk period for overweight/obesity in both mother and child because of excessive gestational weight gain (GWG). The promotion of a healthy GWG is therefore of paramount importance in the context of the prevention of obesity in the current and next generations. Objective. To provide a comprehensive overview of the effect of prenatal physical activity interventions, alone or in combination with nutritional counselling, on GWG and to address whether preventing excessive GWG decreases the incidence of infant high birth weight and/or postpartum weight retention. Method. A search of the PubMed database was conducted to identify all relevant studies. Nineteen studies were included in this review: 13 interventions combining physical activity, nutrition, and GWG counselling and 6 interventions including physical activity alone. Results. Prenatal lifestyle interventions promoting healthy eating and physical activity habits appear to be the most effective approach to prevent excessive GWG. Achievement of appropriate GWG may also decrease the incidence of high infant birth weight and postpartum weight retention. Conclusion. Healthy eating habits during pregnancy, combined with an active lifestyle, may be important elements in the prevention of long-term risk of obesity for two generations.

Published
2012
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154. The human phosphotyrosine signaling network: Evolution and hotspots of hijacking in cancer

Author

Li, Lei, Tibiche, Chabane, Fu, Cong, Kaneko, Tomonori, Moran, Michael F., Schiller, Martin R., Li, Shawn Shun Cheng, Wang, Edwin, Henriksson-Larsen, Kayser, Bengt, Kinnunen, Tarja I., Mottola, Michelle F., Nygaard, Ingrid, Van Poppel, Mireille, Stuge, Britt, and Khan, Karim M.

Subjects
Cell signaling, Cytoplasm, Lineage (genetic), Protein tyrosine phosphatase, protein binding, Cell Communication, Biology, Evolution, Molecular, src Homology Domains, Molecular evolution, Neoplasms, eukaryote, Genetics, Animals, Humans, Bilateria, cell interaction, Phosphorylation, Phosphotyrosine, protein expression, Genetics (clinical), Phylogeny, Vertebrata, Models, Genetic, Research, Metazoa, intracellular signaling, Cell Membrane, Eukaryota, protein tyrosine kinase, Protein-Tyrosine Kinases, Cell biology, Multicellular organism, Organ Specificity, protein SH2, Signal transduction, neoplasm, Proto-oncogene tyrosine-protein kinase Src, Signal Transduction
Abstract

Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment interactions, has been considered to be an evolutionary innovation in multicellular metazoans. However, neither the emergence nor the evolution of the human pTyr signaling system is currently understood. Tyrosine kinase (TK) circuits, each of which consists of a TK writer, a kinase substrate, and a related reader, such as Src homology (SH) 2 domains and pTyr-binding (PTB) domains, comprise the core machinery of the pTyr signaling network. In this study, we analyzed the evolutionary trajectories of 583 literature-derived and 50,000 computationally predicted human TK circuits in 19 representative eukaryotic species and assigned their evolutionary origins. We found that human TK circuits for intracellular pTyr signaling originated largely from primitive organisms, whereas the inter- or extracellular signaling circuits experienced significant expansion in the bilaterian lineage through the "back- wiring" of newly evolved kinases to primitive substrates and SH2/PTB domains. Conversely, the TK circuits that are involved in tissue-specific signaling evolved mainly in vertebrates by the back-wiring of vertebrate substrates to primitive kinases and SH2/PTB domains. Importantly, we found that cancer signaling preferentially employs the pTyr sites, which are linked to more TK circuits. Our work provides insights into the evolutionary paths of the human pTyr signaling circuits and suggests the use of a network approach for cancer intervention through the targeting of key pTyr sites and their associated signaling hubs in the network. © 2012, Published by Cold Spring Harbor Laboratory Press.

Published
2012

155. Capacity-building and Participatory Research Development of a Community-based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Pregnant and Postpartum Aboriginal Women:Information Gathered from Talking Circles

Author

Mottola, Michelle F, Sopper, Maggie M, Doxtator, Lindsay, Big-Canoe, Katie, Prapavessis, Harry, Harris, Stewart, and Hanley, Anthony

Subjects
Maternal and Child Health, Nutritional and Metabolic Diseases, Pregnancy, Obstetrics and Gynecology, Women, Community Health and Preventive Medicine, Healthy Lifestyle, Talking Circles
Abstract

Objectives were to gather information from Talking Circles of Aboriginal women who participated in a maternal Nutrition and Exercise Lifestyle Intervention Program (NELIP) to identify strategies to bring NELIP into the community. Twelve First Nations women participated. Several main themes were identified regarding health: balance, knowledge/education and time management. Benefits of the NELIP were improvement in health, stamina, stress, and a healthy baby, no gestational diabetes and a successful home birth, with social support as an important contributing factor for success. Suggestions for improvement for the NELIP included group walking, and incorporating more traditional foods into the meal plan. The information gathered is the first step in determining strategies using participatory research and capacity-building to develop a community-based NELIP for pregnant Aboriginal women.

Published
2011

161. Archivée: No129-L'exercice physique pendant la grossesse et le postpartum

Author

Davies, Gregory A.L., Wolfe, Larry A., Mottola, Michelle F., and MacKinnon, Catherine

Abstract

Ce document a été archivé, car il contient des informations périmées. Il ne devrait pas être consulté pour un usage clinique, mais uniquement pour des recherches historiques. Veuillez consulter le site web du journal pour les directives les plus récentes.

Published
2018
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163. Guidelines for Physical Activity During Pregnancy

Author

Evenson, Kelly R., primary, Barakat, Ruben, additional, Brown, Wendy J., additional, Dargent-Molina, Patricia, additional, Haruna, Megumi, additional, Mikkelsen, Ellen M., additional, Mottola, Michelle F., additional, Owe, Katrine M., additional, Rousham, Emily K., additional, and Yeo, SeonAe, additional

Published
2013
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171. Exercise and pregnancy in recreational and elite athletes: 2016/17 evidence summary from the IOC Expert Group Meeting, Lausanne. Part 3—exercise in the postpartum period

Author

Bø, Kari, Artal, Raul, Barakat, Ruben, Brown, Wendy J, Davies, Gregory A L, Dooley, Michael, Evenson, Kelly R, Haakstad, Lene A H, Kayser, Bengt, Kinnunen, Tarja I, Larsén, Karin, Mottola, Michelle F, Nygaard, Ingrid, van Poppel, Mireille, Stuge, Britt, and Khan, Karim M

Published
2017
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175. Exercise and pregnancy in recreational and elite athletes: 2016/17 evidence summary from the IOC expert group meeting, Lausanne. Part 4-Recommendations for future research.

Author

Bø, Kari, Artal, Raul, Barakat, Ruben, Brown, Wendy J., Davies, Gregory A. L., Dooley, Mike, Evenson, Kelly R., Haakstad, Lene A. H., Kayser, Bengt, Kinnunen, Tarja I., Larsén, Karin, Mottola, Michelle F., Nygaard, Ingrid, van Poppel`, Mireille, Stuge, Britt, and Khan, Karim M.

Subjects
WOMEN athletes, EXERCISE for pregnant women, PHYSICAL training & conditioning, ELITE athletes, BREASTFEEDING, ATHLETES, EXERCISE, EXERCISE tests, FERTILITY, PHYSICAL fitness
Published
2017
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188. Exercise Is Associated with a Reduction in Gestational Diabetes Mellitus.

Author

CORDERO, YAIZA, MOTTOLA, MICHELLE F., VARGAS, JUANA, BLANCO, MAITE, and BARAKAT, RUBÉN

Subjects
*GESTATIONAL diabetes, *CONFIDENCE intervals, *STATISTICAL correlation, *EXERCISE, *GOODNESS-of-fit tests, *INTERVIEWING, *RESEARCH funding, *T-test (Statistics), *STATISTICAL power analysis, *EFFECT sizes (Statistics), *BODY mass index, *RANDOMIZED controlled trials, *DATA analysis software, *DESCRIPTIVE statistics, *PREVENTION
Abstract

PURPOSE: The objective of this study is to assess the effectiveness of a maternal exercise program (land/aquatic activities, both aerobic and muscular conditioning) in preventing gestational diabetes mellitus (GDM). METHODS: Three hundred and forty-two pregnant women from Spain (age, 33.24 ± 4.3 yr) without obstetric contraindications were recruited for a clinical randomized controlled trial. The intervention group (IG, n = 101) exercised for 60 and 50 min on land and in water, respectively, three times per week. The control group (n = 156) received usual standard care. RESULTS: The prevalence of GDM was reduced in the IG group (IG, 1%, n = 1, vs control group, 8.8%, n = 13 (χ1² = 6.84, P = 0.009)) with a significant risk estimate (odds ratio = 0.103; 95% confidence interval, 0.013-0.803). CONCLUSION: The exercise program performed during pregnancy reduced the prevalence of GDM by preserving glucose tolerance. [ABSTRACT FROM AUTHOR]

Published
2015
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199. Reproduction.

Author

Mottola, Michelle F.

Subjects
WOMEN'S sports, REPRODUCTIVE health, WOMEN'S health, JUMPING, MENSTRUAL cycle, CONCEPTION, PREGNANCY
Abstract

An encyclopedia entry for the reproductive health of women participating in sport is presented. The subject has been a controversial area of discussion for many years. One such controversy was the issue of jumping. Based on myths and theories, the medical profession suggested that jumping displaced the uterus and caused reproductive abnormalities. Because of this medical advice, it was 1992 before women were able to compete in the triple jump at the Olympics. For women with a normal menstrual cycle, moderate physical activity should play no role in preventing conception. Once conception has occurred, recreational activity in moderation has not been linked to early pregnancy wastage or miscarriage.

Published
2005

200. Be Healthy in Pregnancy (BHIP): A Randomized Controlled Trial of Nutrition and Exercise Intervention from Early Pregnancy to Achieve Recommended Gestational Weight Gain.

Author

Atkinson, Stephanie A., Maran, Atherai, Dempsey, Kendra, Perreault, Maude, Vanniyasingam, Thuva, Phillips, Stuart M., Hutton, Eileen K., Mottola, Michelle F., Wahoush, Olive, Xie, Feng, and Thabane, Lehana

Abstract

A randomized two-arm prospective superiority trial tested the efficacy of a novel structured and monitored nutrition (bi-weekly counselling for individualized energy and high dairy protein diet) and exercise program (walking goal of 10,000 steps/day) (intervention) compared to usual care (control) in pregnant women to achieve gestational weight gain (GWG) within current recommendations. Women recruited in communities in southern Ontario, Canada were randomized at 12–17 weeks gestation with stratification by site and pre-pregnancy BMI to intervention (n = 119) or control (n = 122). The primary outcome was the proportion of women who achieved GWG within the Institute of Medicine recommendations. Although the intervention compared to control group was more likely to achieve GWG within recommendations (OR = 1.51; 95% CI (0.81, 2.80)) and total GWG was lower by 1.45 kg (95% CI: (−11.9, 8.88)) neither reached statistical significance. The intervention group achieved significantly higher protein intake at 26–28 week (mean difference (MD); 15.0 g/day; 95% CI (8.1, 21.9)) and 36–38 week gestation (MD = 15.2 g/day; 95% CI (9.4, 21.1)) and higher healthy diet scores (22.5 ± 6.9 vs. 18.7 ± 8.5, p < 0.005) but step counts were similar averaging 6335 steps/day. Pregnancy and infant birth outcomes were similar between groups. While the structured and monitored nutrition with counselling improved diet quality and protein intake and may have benefited GWG, the exercise goal of 10,000 steps/day was unachievable. The results can inform future recommendations for diet and physical activity in pregnancy. [ABSTRACT FROM AUTHOR]

Published
2022
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