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159. Linking Glass-Transition Behavior to Photophysical and Charge Transport Properties of High-Mobility Conjugated Polymers

Author

Xiao, M, Sadhanala, A, Abdi-Jalebi, M, Thomas, TH, Ren, X, Zhang, T, Chen, H, Carey, RL, Wang, Q, Senanayak, SP, Jellett, C, Onwubiko, A, Moser, M, Liao, H, Yue, W, McCulloch, I, Nikolka, M, Sirringhaus, H, Sirringhaus, H [0000-0001-9827-6061], and Apollo - University of Cambridge Repository

Subjects
donor&#8211, dynamic mechanical analysis, conjugated polymers, glass transition, donor–, acceptor polymers, charge transport
Abstract

The measurement of the mechanical properties of conjugated polymers can reveal highly relevant information linking optoelectronic properties to underlying microstructures and the knowledge of the glass transition temperature ( Tg ) is paramount for informing the choice of processing conditions and for interpreting the thermal stability of devices. In this work, we use dynamical mechanical analysis (DMA) to determine Tg of a range of state-of-the-art conjugated polymers with different degrees of crystallinity that are widely studied for applications in organic field-effect transistors (OFETs). We compare our measured values for Tg to the theoretical value predicted by a recent work based on the concept of effective mobility ζ. The comparison shows that for conjugated polymers with a modest length of the monomer units, the Tg values agree well with theoretical predictions. However, for the near-amorphous, indacenodithiophene–benzothiadiazole (IDT-BT) family of polymers with more extended backbone units, values for Tg appear to be significantly higher predicted by theory. We find instead that values for Tg are correlated with the sub-bandgap optical absorption suggesting the possible role of the interchain short contacts within materials’ amorphous domains.

Published
2021

160. ANTARES Search for Point Sources of Neutrinos Using Astrophysical Catalogs: A Likelihood Analysis (ANTARES Collaboration), and

Author

Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Branza, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., Diaz, A. F., De Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Khayati, N., Enzenhofer, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gatelet, Y., Gay, P., Glotin, H., Gozzini, R., Gracia, R., Graf, K., Guidi, C., Hallmann, S., Van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., De Jong, M., De Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefevre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mazzou, S., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nunez-Castineyra, A., O Fearraigh, B., Organokov, M., Pvla, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Poire, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Salesa Greus, F., Samtleben, D. F. E., Sanchez-Losa, A., Sanguineti, M., Sapienza, P., Schnabel, J., Schossler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zegarelli, A., Zornoza, J. D., Zuniga, J., and Buson, S.

Published
2021

162. Monocyte Dysfunction Detected by the Designed Ankyrin Repeat Protein F7 Predicts Mortality in Patients Receiving Veno-Arterial Extracorporeal Membrane Oxygenation

Author

Siegel, PM, Orlean, L, Bojti, I, Kaier, K, Witsch, T, Esser, JS, Trummer, G, Moser, M, Peter, K, Bode, C, Diehl, P, Siegel, PM, Orlean, L, Bojti, I, Kaier, K, Witsch, T, Esser, JS, Trummer, G, Moser, M, Peter, K, Bode, C, and Diehl, P

Abstract

Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is used for critically ill patients requiring hemodynamic support but has been shown to induce an inflammatory response syndrome potentially leading to severe complications and poor outcome. Monocytes are comprised of different subsets and play a central role in the innate immune system. The unique small binding proteins, Designed Ankyrin Repeat Protein "F7" and single chain variable fragment "MAN-1," specifically detect the activated conformation of the leukocyte integrin Mac-1 enabling the highly sensitive detection of monocyte activation status. The aim of this study was to characterize monocyte function and heterogeneity and their association with outcome in VA-ECMO patients. Methods: VA-ECMO patients were recruited from the ICUs of the University Hospital in Freiburg, Germany. Blood was sampled on day 0 and day 3 after VA-ECMO placement, after VA-ECMO explantation and from healthy controls. Monocyte subset distribution, baseline activation and stimulability were analyzed by flow cytometry using the unique small binding proteins F7 and MAN-1 and the conventional activation markers CD163, CD86, CD69, and CX3CR1. Furthermore, expression of monocyte activation markers in survivors and non-survivors on day 0 was compared. Simple logistic regression was conducted to determine the association of monocyte activation markers with mortality. Results: Twenty two patients on VA-ECMO and 15 healthy controls were recruited. Eleven patients survived until discharge from the ICU. Compared to controls, baseline monocyte activation was significantly increased, whereas stimulability was decreased. The percentage of classical monocytes increased after explantation, while the percentage of intermediate monocytes decreased. Total, classical, and intermediate monocyte counts were significantly elevated compared to controls. On day 0, baseline binding of F7 was significantly lower in non-survivors than survivors.

Published
2021

163. A genome-wide association study, supported by a new chromosome-level genome assembly, suggests sox2 as a main driver of the undifferentiatiated ZZ/ZW sex determination of turbot (Scophthalmus maximus)

Author

Martínez, P. (Paulino), Robledo, D. (Diego), Taboada, X. (Xoana), Blanco, A., Moser, M., Maroso, F., Hermida, M., Gómez-Tato, A. (Antonio), Álvarez-Blázquez, B. (Blanca), Cabaleiro, S. (Santiago), Piferrer, F. (Francesc), Bouza, C. (Carmen), Sigborn, L., Viñas, A. (Ana), Martínez, P. (Paulino), Robledo, D. (Diego), Taboada, X. (Xoana), Blanco, A., Moser, M., Maroso, F., Hermida, M., Gómez-Tato, A. (Antonio), Álvarez-Blázquez, B. (Blanca), Cabaleiro, S. (Santiago), Piferrer, F. (Francesc), Bouza, C. (Carmen), Sigborn, L., and Viñas, A. (Ana)

Abstract

Background: Understanding sex determination (SD) across taxa is a major challenge for evolutionary biology. The new genomic tools are paving the way to identify genomic features underlying SD in fish, a group frequently showing limited sex chromosome differentiation and high SD evolutionary turnover. Turbot (Scophthalmus maximus) is a commercially important flatfish with an undifferentiated ZW/ZZ SD system and remarkable sexual dimorphism. Here we describe a new long-read turbot genome assembly used to disentangle the genetic architecture of turbot SD by combining genomics and classical genetics approaches. Results: The new turbot genome assembly consists of 145 contigs (N50 = 22.9 Mb), 27 of them representing >95% of its estimated genome size. A genome wide association study (GWAS) identified a ~ 6.8 Mb region on chromosome 12 associated with sex in 69.4% of the 36 families analyzed. The highest associated markers flanked sox2, the only gene in the region showing differential expression between sexes before gonad differentiation. A single SNP showed consistent differences between Z and W chromosomes. The analysis of a broad sample of families suggested the presence of additional genetic and/or environmental factors on turbot SD. Conclusions: The new chromosome-level turbot genome assembly, one of the most contiguous fish assemblies to date, facilitated the identification of sox2 as a consistent candidate gene putatively driving SD in this species. This chromosome SD system barely showed any signs of differentiation, and other factors beyond the main QTL seem to control SD in a certain proportion of families.

Published
2021

181. Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis

Author

Coquerelle, C., Oldenhove, G., Acolty, V., Denoeud, J., Vansanten, G., Verdebout, J.-M., Mellor, A., Bluestone, J.A., and Moser, M.

Subjects
Colitis -- Care and treatment, Colitis -- Patient outcomes, Colitis -- Research, Interleukin-10 -- Physiological aspects, Interleukin-10 -- Research, T cells -- Physiological aspects, T cells -- Research, Monoclonal antibodies -- Dosage and administration, Monoclonal antibodies -- Research, Health
Published
2009

184. Measurement of the atmospheric ν and ν energy spectra with the ANTARES neutrino telescope

Author

Albert, A., primary, Alves, S., additional, André, M., additional, Anghinolfi, M., additional, Anton, G., additional, Ardid, M., additional, Aubert, J.-J., additional, Aublin, J., additional, Baret, B., additional, Basa, S., additional, Belhorma, B., additional, Bendahman, M., additional, Bertin, V., additional, Biagi, S., additional, Bissinger, M., additional, Boumaaza, J., additional, Bouta, M., additional, Bouwhuis, M.C., additional, Brânzaş, H., additional, Bruijn, R., additional, Brunner, J., additional, Busto, J., additional, Capone, A., additional, Caramete, L., additional, Carr, J., additional, Carretero, V., additional, Celli, S., additional, Chabab, M., additional, Chau, T.N., additional, Cherkaoui El Moursli, R., additional, Chiarusi, T., additional, Circella, M., additional, Coleiro, A., additional, Colomer-Molla, M., additional, Coniglione, R., additional, Coyle, P., additional, Creusot, A., additional, Díaz, A.F., additional, de Wasseige, G., additional, Deschamps, A., additional, Distefano, C., additional, Di Palma, I., additional, Domi, A., additional, Donzaud, C., additional, Dornic, D., additional, Drouhin, D., additional, Eberl, T., additional, El Khayati, N., additional, Enzenhöfer, A., additional, Fermani, P., additional, Ferrara, G., additional, Filippini, F., additional, Fusco, L., additional, García, R., additional, Gatelet, Y., additional, Gay, P., additional, Glotin, H., additional, Gozzini, R., additional, Graf, K., additional, Guidi, C., additional, Hallmann, S., additional, van Haren, H., additional, Heijboer, A.J., additional, Hello, Y., additional, Hernández-Rey, J.J., additional, Hößl, J., additional, Hofestädt, J., additional, Huang, F., additional, Illuminati, G., additional, James, C.W., additional, Jisse-Jung, B., additional, de Jong, M., additional, de Jong, P., additional, Jongen, M., additional, Kadler, M., additional, Kalekin, O., additional, Katz, U., additional, Khan-Chowdhury, N.R., additional, Kouchner, A., additional, Kreykenbohm, I., additional, Kulikovskiy, V., additional, Lahmann, R., additional, Le Breton, R., additional, Lefèvre, D., additional, Leonora, E., additional, Levi, G., additional, Lincetto, M., additional, Lopez-Coto, D., additional, Loucatos, S., additional, Maderer, L., additional, Manczak, J., additional, Marcelin, M., additional, Margiotta, A., additional, Marinelli, A., additional, Martínez-Mora, J.A., additional, Melis, K., additional, Migliozzi, P., additional, Moser, M., additional, Moussa, A., additional, Muller, R., additional, Nauta, L., additional, Navas, S., additional, Nezri, E., additional, Nuñez-Castiñeyra, A., additional, O'Fearraigh, B., additional, Organokov, M., additional, Păvălaş, G.E., additional, Pellegrino, C., additional, Perrin-Terrin, M., additional, Piattelli, P., additional, Pieterse, C., additional, Poirè, C., additional, Popa, V., additional, Pradier, T., additional, Randazzo, N., additional, Reck, S., additional, Riccobene, G., additional, Salesa Greus, F., additional, Samtleben, D.F.E., additional, Sánchez-Losa, A., additional, Sanguineti, M., additional, Sapienza, P., additional, Schnabel, J., additional, Schumann, J., additional, Schüssler, F., additional, Spurio, M., additional, Stolarczyk, Th., additional, Taiuti, M., additional, Tayalati, Y., additional, Thakore, T., additional, Tingay, S.J., additional, Vallage, B., additional, Van Elewyck, V., additional, Versari, F., additional, Viola, S., additional, Vivolo, D., additional, Wilms, J., additional, Zegarelli, A., additional, Zornoza, J.D., additional, and Zúñiga, J., additional

Published
2021
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187. ANTARES Search for Point Sources of Neutrinos Using Astrophysical Catalogs: A Likelihood Analysis

Author

Albert, A., primary, André, M., additional, Anghinolfi, M., additional, Anton, G., additional, Ardid, M., additional, Aubert, J.-J., additional, Aublin, J., additional, Baret, B., additional, Basa, S., additional, Belhorma, B., additional, Bertin, V., additional, Biagi, S., additional, Bissinger, M., additional, Boumaaza, J., additional, Bouta, M., additional, Bouwhuis, M. C., additional, Brânzaş, H., additional, Bruijn, R., additional, Brunner, J., additional, Busto, J., additional, Capone, A., additional, Caramete, L., additional, Carr, J., additional, Carretero, V., additional, Celli, S., additional, Chabab, M., additional, Chau, T. N., additional, Cherkaoui El Moursli, R., additional, Chiarusi, T., additional, Circella, M., additional, Coleiro, A., additional, Colomer-Molla, M., additional, Coniglione, R., additional, Coyle, P., additional, Creusot, A., additional, Díaz, A. F., additional, de Wasseige, G., additional, Deschamps, A., additional, Distefano, C., additional, Di Palma, I., additional, Domi, A., additional, Donzaud, C., additional, Dornic, D., additional, Drouhin, D., additional, Eberl, T., additional, El Khayati, N., additional, Enzenhöfer, A., additional, Fermani, P., additional, Ferrara, G., additional, Filippini, F., additional, Fusco, L., additional, Gatelet, Y., additional, Gay, P., additional, Glotin, H., additional, Gozzini, R., additional, Gracía, R., additional, Graf, K., additional, Guidi, C., additional, Hallmann, S., additional, van Haren, H., additional, Heijboer, A. J., additional, Hello, Y., additional, Hernández-Rey, J. J., additional, Hößl, J., additional, Hofestädt, J., additional, Huang, F., additional, Illuminati, G., additional, James, C. W., additional, Jisse-Jung, B., additional, de Jong, M., additional, de Jong, P., additional, Jongen, M., additional, Kadler, M., additional, Kalekin, O., additional, Katz, U., additional, Khan-Chowdhury, N. R., additional, Kouchner, A., additional, Kreykenbohm, I., additional, Kulikovskiy, V., additional, Lahmann, R., additional, Breton, R. Le, additional, Lefèvre, D., additional, Leonora, E., additional, Levi, G., additional, Lincetto, M., additional, Lopez-Coto, D., additional, Loucatos, S., additional, Maderer, L., additional, Manczak, J., additional, Marcelin, M., additional, Margiotta, A., additional, Marinelli, A., additional, Martínez-Mora, J. A., additional, Mazzou, S., additional, Melis, K., additional, Migliozzi, P., additional, Moser, M., additional, Moussa, A., additional, Muller, R., additional, Nauta, L., additional, Navas, S., additional, Nezri, E., additional, Nuñez-Castiñeyra, A., additional, O’Fearraigh, B., additional, Organokov, M., additional, Păvălaş, G. E., additional, Pellegrino, C., additional, Perrin-Terrin, M., additional, Piattelli, P., additional, Pieterse, C., additional, Poirè, C., additional, Popa, V., additional, Pradier, T., additional, Randazzo, N., additional, Reck, S., additional, Riccobene, G., additional, Salesa Greus, F., additional, Samtleben, D. F. E., additional, Sánchez-Losa, A., additional, Sanguineti, M., additional, Sapienza, P., additional, Schnabel, J., additional, Schüssler, F., additional, Spurio, M., additional, Stolarczyk, Th., additional, Taiuti, M., additional, Tayalati, Y., additional, Thakore, T., additional, Tingay, S. J., additional, Vallage, B., additional, Van Elewyck, V., additional, Versari, F., additional, Viola, S., additional, Vivolo, D., additional, Wilms, J., additional, Zegarelli, A., additional, Zornoza, J. D., additional, Zúñiga, J., additional, and Buson, S., additional

Published
2021
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188. ANTARES upper limits on the multi-TeV neutrino emission from the GRBs detected by IACTs

Author

Albert, A., additional, André, M., additional, Anghinolfi, M., additional, Anton, G., additional, Ardid, M., additional, Aubert, J.-J., additional, Aublin, J., additional, Baret, B., additional, Basa, S., additional, Belhorma, B., additional, Bertin, V., additional, Biagi, S., additional, Bissinger, M., additional, Boumaaza, J., additional, Bouta, M., additional, Bouwhuis, M.C., additional, Brânzaş, H., additional, Bruijn, R., additional, Brunner, J., additional, Busto, J., additional, Capone, A., additional, Caramete, L., additional, Carr, J., additional, Carretero, V., additional, Celli, S., additional, Chabab, M., additional, Chau, T.N., additional, Cherkaoui El Moursli, R., additional, Chiarusi, T., additional, Circella, M., additional, Coleiro, A., additional, Colomer-Molla, M., additional, Coniglione, R., additional, Coyle, P., additional, Creusot, A., additional, Díaz, A.F., additional, de Wasseige, G., additional, Deschamps, A., additional, Distefano, C., additional, Di Palma, I., additional, Domi, A., additional, Donzaud, C., additional, Dornic, D., additional, Drouhin, D., additional, Eberl, T., additional, El Khayati, N., additional, Enzenhöfer, A., additional, Ettahiri, A., additional, Fermani, P., additional, Ferrara, G., additional, Filippini, F., additional, Fusco, L., additional, García, R., additional, Gay, P., additional, Glotin, H., additional, Gozzini, R., additional, Graf, K., additional, Guidi, C., additional, Hallmann, S., additional, van Haren, H., additional, Heijboer, A.J., additional, Hello, Y., additional, Hernández-Rey, J.J., additional, Hößl, J., additional, Hofestädt, J., additional, Huang, F., additional, Illuminati, G., additional, James, C.W., additional, Jisse-Jung, B., additional, de Jong, M., additional, de Jong, P., additional, Jongen, M., additional, Kadler, M., additional, Kalekin, O., additional, Katz, U., additional, Khan-Chowdhury, N.R., additional, Kouchner, A., additional, Kreykenbohm, I., additional, Kulikovskiy, V., additional, Lahmann, R., additional, Le Breton, R., additional, Lefèvre, D., additional, Leonora, E., additional, Levi, G., additional, Lincetto, M., additional, Lopez-Coto, D., additional, Loucatos, S., additional, Maderer, L., additional, Manczak, J., additional, Marcelin, M., additional, Margiotta, A., additional, Marinelli, A., additional, Martínez-Mora, J.A., additional, Mazzou, S., additional, Melis, K., additional, Migliozzi, P., additional, Moser, M., additional, Moussa, A., additional, Muller, R., additional, Nauta, L., additional, Navas, S., additional, Nezri, E., additional, Nuñez-Castiñeyra, A., additional, O'Fearraigh, B., additional, Organokov, M., additional, Păvălaş, G.E., additional, Pellegrino, C., additional, Perrin-Terrin, M., additional, Piattelli, P., additional, Pieterse, C., additional, Poirè, C., additional, Popa, V., additional, Pradier, T., additional, Randazzo, N., additional, Reck, S., additional, Riccobene, G., additional, Sánchez-Losa, A., additional, Samtleben, D.F.E., additional, Sanguineti, M., additional, Sapienza, P., additional, Schnabel, J., additional, Schüssler, F., additional, Spurio, M., additional, Stolarczyk, Th., additional, Taiuti, M., additional, Tayalati, Y., additional, Thakore, T., additional, Tingay, S.J., additional, Vallage, B., additional, Van Elewyck, V., additional, Versari, F., additional, Viola, S., additional, Vivolo, D., additional, Wilms, J., additional, Zegarelli, A., additional, Zornoza, J.D., additional, and Zúñiga, J., additional

Published
2021
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190. Novel Aspects on The Interaction Between Grapevine and Plasmopara viticola: Dual-RNA-Seq Analysis Highlights Gene Expression Dynamics in The Pathogen and The Plant During The Battle For Infection

Author

Toffolatti, S.L., De Lorenzis, G., Brilli, M., Moser, M., Shariati, V., Tavakol, E., Maddalena, G., Passera, A., Casati, P., Pindo, M., Cestaro, A., Maghradze, D., Failla, O., Bianco, P.A., and Quaglino, F.

Subjects
lcsh:QH426-470, Sequence Analysis, RNA, resistance genes, fungi, plant–pathogen interaction, food and beverages, Article, oomycete effectors, Plant Leaves, Settore AGR/07 - GENETICA AGRARIA, lcsh:Genetics, Oomycetes, Gene Expression Regulation, Plant, rna-seq, Host-Pathogen Interactions, disease resistance and susceptibility, Vitis, susceptibility genes, transcriptome, Disease Resistance, Plant Diseases
Abstract

Mgaloblishvili, a Vitis vinifera cultivar, exhibits unique resistance traits against Plasmopara viticola, the downy mildew agent. This offers the unique opportunity of exploring the molecular responses in compatible and incompatible plant-pathogen interaction. In this study, whole transcriptomes of Mgaloblishvili, Pinot noir (a V. vinifera susceptible cultivar), and Bianca (a resistant hybrid) leaves, inoculated and non-inoculated with the pathogen, were used to identify P. viticola effector-encoding genes and plant susceptibility/resistance genes. Multiple effector-encoding genes were identified in P. viticola transcriptome, with remarkable expression differences in relation to the inoculated grapevine cultivar. Intriguingly, five apoplastic effectors specifically associated with resistance in V. vinifera. Gene coexpression network analysis identified specific modules and metabolic changes occurring during infection in the three grapevine cultivars. Analysis of these data allowed, for the first time, the detection in V. vinifera of a putative P. viticola susceptibility gene, encoding a LOB domain-containing protein. Finally, the de novo assembly of Mgaloblishvili, Pinot noir, and Bianca transcriptomes and their comparison highlighted novel candidate genes that might be at the basis of the resistant phenotype. These results open the way to functional analysis studies and to new perspectives in molecular breeding of grapevine for resistance to P. viticola.

Published
2020

191. Scopazzi del melo. Stato attuale della ricerca/Apfeltriebsucht. Aktueller stand der forschung

Author

Barthel, D., Fischnaller, S., Letschka, T., Janil, K., Mittelberger, C., Ottl, S., Panassiti, B., Angeli, G., Baldessari, M., Bianchedi, P. L., Campisano, A., Covelli, L. T., Dallago, G., Ioriatti, C., Mazzoni, V., Moser, M., Pedrazzoli, F., Rota-Stabeli, O., Weil, T., Oppendisano, T., Anfora, G., Jarausch, W., Osterreicher, J., Unterthurner, M., Schweigkofler, W., Tedeschi, R., and Schuler, H.

Published
2020

192. The energy calibration system for CANDLES using (n, ��) reaction

Author

Iida, T., Mizukoshi, K., Ohata, T., Uehara, T., Batpurev, T., Chan, W. M., Fushimi, K., Hazama, R., Ishikawa, M., Kakubata, H., Kanagawa, K., Katagiri, S., Khai, B. T., Kishimoto, T., Li, X., Maeda, T., Matsuoka, K., Morishita, K., Moser, M., Nakajima, K., Nomachi, M., Ogawa, I., Shokati, M., Suzuki, K., Takemoto, Y., Takihira, Y., Tamagawa, Y., Tetsuno, K., Trang, V. T. T., Umehara, S., and Yoshida, S.

Subjects
High Energy Physics - Experiment (hep-ex), Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment (nucl-ex)
Abstract

CAlcium fluoride for the study of Neutrinos and Dark matters by Low-energy Spectrometer (CANDLES) searches for neutrino-less double beta decay of $^{48}$Ca using a CaF$_2$ scintillator array. A high Q-value of $^{48}$Ca at 4,272 keV enabled us to achieve very low background condition, however, at the same it causes difficulties in calibrating the detector's Q-value region because of the absence of a standard high-energy $��$-ray source. Therefore, we have developed a novel calibration system based on $��$-ray emission by neutron capture on $^{28}$Si, $^{56}$Fe and $^{58}$Ni nuclei. In the paper, we report the development of the new calibration system as well as the results of energy calibration in CANDLES up to 9 MeV., 6 pages, 7 figures

Published
2020
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193. Apple Proliferation. A Joint Review

Author

Barthel, D., Fischnaller, S., Letschka, T., Janil, K., Mittelberger, C., Ottl, S., Panassiti, B., Angeli, G., Baldessari, M., Bianchedi, P. L., Campisano, A., Covelli, L. T., Dallago, G., Ioriatti, C., Mazzoni, V., Moser, M., Pedrazzoli, F., Rota-Stabeli, O., Weil, T., Oppendisano, T., Anfora, G., Jarausch, W., Osterreicher, J., Unterthurner, M., Schweigkofler, W., Tedeschi, R., and Schuler, H.

Published
2020

194. Deep-sea deployment of the KM3NeT neutrino telescope detection units by self-unrolling

Author

Aiello, S. Albert, A. Alves Garre, S. Aly, Z. Ameli, F. Anassontzis, E.G. Andre, M. Androulakis, G. Anghinolfi, M. Anguita, M. Anton, G. Ardid, M. Aublin, J. Bagatelas, C. Bakker, R. Barbarino, G. Baret, B. Basegmez du Pree, S. Bendahman, M. Berbee, E. van den Berg, A.M. Bertin, V. Biagi, S. Billault, M. Bissinger, M. Boettcher, M. Boumaaza, J. Bouta, M. Bouwhuis, M. Bozza, C. Brânzas, H. Bruijn, R. Brunner, J. Buis, E. Buompane, R. Busto, J. Cacopardo, G. Caiffi, B. Caillat, L. Calvo, D. Capone, A. Carretero, V. Castaldi, P. Celli, S. Chabab, M. Chau, N. Chen, A. Cherubini, S. Chiarella, V. Chiarusi, T. Circella, M. Cocimano, R. Coelho, J.A.B. Coleiro, A. Colomer Molla, M. Colonges, S. Coniglione, R. Corredoira, I. Cosquer, A. Coyle, P. Creusot, A. Cuttone, G. D’Amato, C. D’Onofrio, A. Dallier, R. de Palma, M. Di Palma, I. Díaz, A.F. Diego-Tortosa, D. Distefano, C. Domi, A. Donà, R. Donzaud, C. Dornic, D. Dörr, M. Drouhin, D. Eberl, T. Eddyamoui, A. van Eeden, T. van Eijk, D. El Bojaddaini, I. Elsaesser, D. Enzenhöfer, A. Espinosa, V. Fermani, P. Ferrara, G. Filipovic, M.D. Filippini, F. Fusco, L.A. Gabella, O. Gal, T. Garcia Soto, A. Garufi, F. Gatelet, Y. Geißelbrecht, N. Gialanella, L. Giorgio, E. Gostiaux, L. Gozzini, S.R. Gracia, R. Graf, K. Grasso, D. Grella, G. Grmek, A. Guderian, D. Guidi, C. Hallmann, S. Hamdaoui, H. van Haren, H. van Heerwaarden, J. Heijboer, A. Hekalo, A. Henry, S. Hernández-Rey, J.J. Hillebrand, T. Hofestädt, J. Huang, F. Idrissi Ibnsalih, W. Ilioni, A. Illuminati, G. James, C.W. de Jong, M. de Jong, P. Jung, B.J. Kadler, M. Kalaczynski, P. Kalekin, O. Katz, U.F. Khan Chowdhury, N.R. Kistauri, G. van der Knaap, F. Koffeman, E.N. Kooijman, P. Kouchner, A. Kreter, M. Kulikovskiy, V. Laan, M. Lahmann, R. Lamare, P. Larosa, G. Laurence, J. Le Breton, R. Leonardi, O. Leone, F. Leonora, E. Levi, G. Lincetto, M. Lindsey Clark, M. Lipreau, T. Longhitano, F. Lopez-Coto, D. Maderer, L. Manczak, J. Mannheim, K. Margiotta, A. Marinelli, A. Markou, C. Martin, L. Martínez-Mora, J.A. Martini, A. Marzaioli, F. Mastroianni, S. Mazzou, S. Melis, K.W. Miele, G. Migliozzi, P. Migneco, E. Mijakowski, P. Miranda, L.S. Mollo, C.M. Mongelli, M. Morganti, M. Moser, M. Moussa, A. Muller, R. Muñoz Pérez, D. Musumeci, M. Nauta, L. Navas, S. Nicolau, C.A. Ó Fearraigh, B. O’Sullivan, M. Organokov, M. Orlando, A. Palacios González, J. Papalashvili, G. Papaleo, R. Pastore, C. Paun, A.M. Pavalas, G.E. Pellegrino, C. Perrin-Terrin, M. Piattelli, P. Pieterse, C. Pikounis, K. Pisanti, O. Poirè, C. Popa, V. Pradier, T. Pühlhofer, G. Pulvirenti, S. Rabyang, O. Raffaelli, F. Randazzo, N. Razzaque, S. Real, D. Reck, S. Riccobene, G. Richer, M. Rivoire, S. Rovelli, A. Salesa Greus, F. Samtleben, D.F.E. Sánchez Losa, A. Sanguineti, M. Santangelo, A. Santonocito, D. Sapienza, P. Schnabel, J. Schumann, J. Seneca, J. Sgura, I. Shanidze, R. Sharma, A. Simeone, F. Sinopoulou, A. Spisso, B. Spurio, M. Stavropoulos, D. Steijger, J. Stellacci, S.M. Taiuti, M. Tayalati, Y. Tenllado, E. Tézier, D. Thakore, T. Tingay, S. Tzamariudaki, E. Tzanetatos, D. van Elewyck, V. Vasileiadis, G. Versari, F. Viola, S. Vivolo, D. de Wasseige, G. Wilms, J. Wojaczynski, R. de Wolf, E. Zavatarelli, S. Zegarelli, A. Zito, D. Zornoza, J.D. Zúñiga, J. Zywucka, N. The KM3NeT Collaboration

Abstract

KM3NeT is a research infrastructure being installed in the deep Mediterranean Sea. It will house a neutrino telescope comprising hundreds of networked moorings — detection units or strings — equipped with optical instrumentation to detect the Cherenkov radiation generated by charged particles from neutrino-induced collisions in its vicinity. In comparison to moorings typically used for oceanography, several key features of the KM3NeT string are different: the instrumentation is contained in transparent and thus unprotected glass spheres; two thin Dyneema® ropes are used as strength members; and a thin delicate backbone tube with fibre-optics and copper wires for data and power transmission, respectively, runs along the full length of the mooring. Also, compared to other neutrino telescopes such as ANTARES in the Mediterranean Sea and GVD in Lake Baikal, the KM3NeT strings are more slender to minimise the amount of material used for support of the optical sensors. Moreover, the rate of deploying a large number of strings in a period of a few years is unprecedented. For all these reasons, for the installation of the KM3NeT strings, a custom-made, fast deployment method was designed. Despite the length of several hundreds of metres, the slim design of the string allows it to be compacted into a small, re-usable spherical launching vehicle instead of deploying the mooring weight down from a surface vessel. After being lowered to the seafloor, the string unfurls to its full length with the buoyant launching vehicle rolling along the two ropes. The design of the vehicle, the loading with a string, and its underwater self-unrolling are detailed in this paper. © 2020 The Author(s). Published by IOP Publishing Ltd on behalf of Sissa Medialab. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

Published
2020

195. Piante ospiti del fitoplasma degli scopazzi del melo

Author

Barthel, D., Bianchedi, P., Campisano, A., Covelli, L.T., Dallago, G., Ioriatti, C., Jarausch, W., Letschka, T., Mittelberger, C., Moser, M., Öttl, S., Österreicher, J., Schweigkofler, W., Tedeschi, R., Unterthurner, M., and Janik, K.

Subjects
Settore AGR/12 - PATOLOGIA VEGETALE
Published
2020

198. Co-extraction of iron and sulphate by bis(2,4,4-trimethylpentyl)phosphinic acid, CYANEX272

Author

Carson I., Fischmann A.J., Jakovljevic B., Love J.B., Morrison C.A., Moser M., Soderstrom M.D., Tasker P.A., Carson I., Fischmann A.J., Jakovljevic B., Love J.B., Morrison C.A., Moser M., Soderstrom M.D., and Tasker P.A.

Abstract

The mode of action of iron(III) uptake from sulphate solutions by the commercial extractant CYANEX272, bis(2,4,4-trimethylpentyl)phosphinic acid, has been studied using conventional solvent extraction methods, together with 31P{1 H} NMR spectroscopy, electrospray ionisation mass spectrometry, and DFT calculations that have not previously been used to analyse the content of the ISOPAR M water-immiscible phase. The maximum Fe-loading recorded was 177% of the theoretical maximum, based on the formation of an Fe(III) complex [Fe(L)3] with a 1:3 molar ratio of Fe to phosphinate (L). Inductively coupled plasma optical emission spectroscopy (ICP-OES) indicates that sulphate or hydrogen sulphate ions are co-extracted in a 1:2 molar ratio with iron across the whole of the Fe-loading range, which helps to account for the loadings being greater than 100% of the theoretical value. 31P{1 H} NMR spectroscopy indicates that the limiting factor in Fe-loading is the availability of uncomplexed CYANEX272 (sulphate is present in large excess). In contrast to the behaviour of Co(II) and Zn(II) extraction by CYANEX272, there is no evidence for the formation of polymeric Fe(III) complexes and highly viscous solutions at high metal loadings. The identity of the extracted species is likely to be a polynuclear Fe(III) sulphate complex., The mode of action of iron(III) uptake from sulphate solutions by the commercial extractant CYANEX272, bis(2,4,4-trimethylpentyl)phosphinic acid, has been studied using conventional solvent extraction methods, together with 31P{1 H} NMR spectroscopy, electrospray ionisation mass spectrometry, and DFT calculations that have not previously been used to analyse the content of the ISOPAR M water-immiscible phase. The maximum Fe-loading recorded was 177% of the theoretical maximum, based on the formation of an Fe(III) complex [Fe(L)3] with a 1:3 molar ratio of Fe to phosphinate (L). Inductively coupled plasma optical emission spectroscopy (ICP-OES) indicates that sulphate or hydrogen sulphate ions are co-extracted in a 1:2 molar ratio with iron across the whole of the Fe-loading range, which helps to account for the loadings being greater than 100% of the theoretical value. 31P{1 H} NMR spectroscopy indicates that the limiting factor in Fe-loading is the availability of uncomplexed CYANEX272 (sulphate is present in large excess). In contrast to the behaviour of Co(II) and Zn(II) extraction by CYANEX272, there is no evidence for the formation of polymeric Fe(III) complexes and highly viscous solutions at high metal loadings. The identity of the extracted species is likely to be a polynuclear Fe(III) sulphate complex.

Published
2020

199. Reduced methane seepage from Arctic sediments during cold bottom-water conditions

Author

Ferré, B., Jansson, P.G., Moser, M., Serov, P., Portnov, A., Graves, C.A., Panieri, G., Gründger, F., Berndt, C., Lehmann, M.F., Niemann, H., Ferré, B., Jansson, P.G., Moser, M., Serov, P., Portnov, A., Graves, C.A., Panieri, G., Gründger, F., Berndt, C., Lehmann, M.F., and Niemann, H.

Abstract

Large amounts of methane are trapped within gas hydrate in subseabed sediments in the Arctic Ocean, and bottom-water warming may induce the release of methane from the seafloor. Yet the effect of seasonal temperature variations on methane seepage activity remains unknown as surveys in Arctic seas are conducted mainly in summer. Here we compare the activity of cold seeps along the gas hydrate stability limit offshore Svalbard during cold (May 2016) and warm (August 2012) seasons. Hydro-acoustic surveys revealed a substantially decreased seepage activity during cold bottom-water conditions, corresponding to a 43% reduction of total cold seeps and methane release rates compared with warmer conditions. We demonstrate that cold seeps apparently hibernate during cold seasons, when more methane gas becomes trapped in the subseabed sediments. Such a greenhouse gas capacitor increases the potential for methane release during summer months. Seasonal bottom-water temperature variations are common on the Arctic continental shelves. We infer that methane-seep hibernation is a widespread phenomenon that is underappreciated in global methane budgets, leading to overestimates in current calculations.

Published
2020

200. Cardiomyocyte microvesicles: proinflammatory mediators after myocardial ischemia?

Author

Siegel, PM, Schmich, J, Barinov, G, Bojti, I, Vedecnik, C, Simanjuntak, NR, Bode, C, Moser, M, Peterz, K, Diehl, P, Siegel, PM, Schmich, J, Barinov, G, Bojti, I, Vedecnik, C, Simanjuntak, NR, Bode, C, Moser, M, Peterz, K, and Diehl, P

Abstract

Myocardial infarction is a frequent complication of cardiovascular disease leading to high morbidity and mortality worldwide. Elevated C-reactive protein (CRP) levels after myocardial infarction are associated with heart failure and poor prognosis. Cardiomyocyte microvesicles (CMV) are released during hypoxic conditions and can act as mediators of intercellular communication. MicroRNA (miRNA) are short non-coding RNA which can alter cellular mRNA-translation. Microvesicles (MV) have been shown to contain distinct patterns of miRNA from their parent cells which can affect protein expression in target cells. We hypothesized that miRNA containing CMV mediate hepatic CRP expression after cardiomyocyte hypoxia. H9c2-cells were cultured and murine cardiomyocytes were isolated from whole murine hearts. H9c2- and murine cardiomyocytes were exposed to hypoxic conditions using a hypoxia chamber. Microvesicles were isolated by differential centrifugation and analysed by flow cytometry. Next-generation-sequencing was performed to determine the miRNA-expression profile in H9c2 CMV compared to their parent cells. Microvesicles were incubated with a co-culture model of the liver consisting of THP-1 macrophages and HepG2 cells. IL-6 and CRP expression in the co-culture was assessed by qPCR and ELISA. CMV contain a distinct pattern of miRNA compared to their parent cells including many inflammation-related miRNA. CMV induced IL-6 expression in THP-1 macrophages alone and CRP expression in the hepatic co-culture model. MV from hypoxic cardiomyocytes can mediate CRP expression in a hepatic co-culture model. Further studies will have to show whether these effects are reproducible in-vivo.

Published
2020

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