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Thoracic endovascular repair (TEVAR) is a valuable alternative to open surgical repair for aortic aneurysms, offering several benefits. However, one potential complication that demands attention is endoleak. This case report highlights a unique occurrence of type 2 endoleak, typically associated with aortic aneurysms treated by TEVAR, originating from an undiagnosed patent ductus arteriosus (PDA). The patient, a 68-year-old woman, underwent TEVAR for an aortic aneurysm complicated by underlying lung disease and pulmonary artery hypertension. During the procedure, an unexpected shunt between the aorta and the pulmonary artery was identified and subsequently revealed to be an undiagnosed PDA. Remarkably, the decision was made to continue with TEVAR while simultaneously deploying a stent graft to close the PDA. This case underscores the significance of comprehensive preprocedural aortic assessment and careful consideration of PDA closure to prevent type 2 endoleak in TEVAR, reinforcing the importance of thorough evaluation before such procedures.

Background: Artificial intelligence (AI) techniques have been ascertained useful in the analysis and description of infectious areas in radiological images promptly. Our aim in this study was to design a web-based application for detecting and labeling infected tissues on CT (computed tomography) lung images of patients based on the deep learning (DL) method as a type of AI. Materials and Methods: The U-Net architecture, one of the DL networks, is used as a hybrid model with pre-trained densely connected convolutional network 121 (DenseNet121) architecture for the segmentation process. The proposed model was constructed on 1031 persons' CT-scan images from Ibn Sina Hospital of Iran in 2021 and some publicly available datasets. The network was trained using 6000 slices, validated on 1000 slices images, and tested against the 150 slices. Accuracy, sensitivity, specificity, and area under the receiver operating characteristics (ROC) curve (AUC) were calculated to evaluate model performance. Results: The results indicate the acceptable ability of the U-Net-DenseNet121 model in detecting COVID-19 abnormality (accuracy = 0.88 and AUC = 0.96 for thresholds of 0.13 and accuracy = 0.88 and AUC = 0.90 for thresholds of 0.2). Based on this model, we developed the“Imaging-Tech” web-based application for use at hospitals and clinics to make our project's output more practical and attractive in the market. Conclusion: We designed a DL-based model for the segmentation of COVID-19 CT scan images and, based on this model, constructed a web-based application that, according to the results, is a reliable detector for infected tissue in lung CT-scans. The availability of such tools would aid in automating, prioritizing, fastening, and broadening the treatment of COVID-19 patients globally.

Background and purpose: In December 2019, a series of pneumonia cases of unknown origin were reported in Wuhan, China, named by the World Health Organization as COVID-19. The risk factors for developing the disease of COVID-19 are still not well known, but evidence shows that some factors, including respiratory diseases such as tuberculosis, are important risk factors in the disease of COVID-19. It should be noted that tuberculosis, like SARS-COV-2, is mainly transmitted through breathing and affects the lungs. Also, some studies show that infection with Mycobacterium tuberculosis causes more rapid and severe pneumonia symptoms in COVID-19 and is the main cause of death due to severe disease. Considering that the disease of COVID-19 is a newly emerging pandemic and the risk factors related to its incidence and severity are still being investigated and considering that tuberculosis is a curable infectious disease that can affect other respiratory diseases. This study was conducted to investigate the probable and definite frequency of COVID-19 (COVID-19) in the first and second peaks of the coronavirus pandemic among patients with a history of tuberculosis. Materials and methods: This study was descriptive-cross-sectional and the study population included patients with a history of tuberculosis whose diagnosis date was between 2015 and 2020. The number of these samples was equal to 1532. The sampling method was census. The time of investigation in terms of contracting COVID-19 was after the first peak and during and after the second peak of Corona (from the second half of May 2019 to November 2019). The data collection tool included a checklist containing demographic variables and clinical symptoms related to COVID-19. The method of collecting information was in the form of telephone interviews and document review. Data collection was done by trained interviewers. For this purpose, the questioners were first given the necessary training on how to complete the checklist. Data entry was done in Excel software and transferred to SPSS V.16 software for analysis. The description of the variables is presented in terms of number, percentage, mean, standard deviation, and median. A chi-square test was conducted to compare the grouped variables. Results: In this study, the prevalence of probable and definite cases of COVID-19 among patients with a history of tuberculosis was reported as 5.5% (85 people), and suspected, probable and definite cases were reported as 15.6% (239 people). Also, there was no correlation between age groups, gender, place of residence, type of tuberculosis, marriage, diabetes, kidney disease dialysis, immunodeficiency,, and liver disease with the prevalence of COVID-19 among patients with a history of tuberculosis. It should be noted that in this group of patients, heart disease, lung disease, cancer, chemotherapy, high blood pressure, and brain and nerve diseases were related to the spread of COVID-19. Also, the highest frequency of suspected, probable, and definite COVID among patients with a history of tuberculosis was diagnosed respectively in 2019 with 38.5% (25 out of 65 cases with a history of tuberculosis), in 2014 with 26.7% (63 out of 236 cases with a history of tuberculosis) and 20.8% (58 people out of 279 cases with a history of tuberculosis) in 2018. Conclusion: Due to the significant difference in the prevalence of Covid 19 in patients who have not received the flu vaccine, it is necessary to inject the flu vaccine in these patients. Advice to quit smoking in these patients should be a priority. Because no independent study on Covid disease was observed in patients with tuberculosis, further studies in this field are necessary.

Abstract Intra-tumor heterogeneity compromises the clinical value of transcriptomic classifications of colorectal cancer. We investigated the prognostic effect of transcriptomic heterogeneity and the potential for classifications less vulnerable to heterogeneity in a single-hospital series of 1093 tumor samples from 692 patients, including multiregional samples from 98 primary tumors and 35 primary-metastasis sets. We show that intra-tumor heterogeneity of the consensus molecular subtypes (CMS) is frequent and has poor-prognostic associations independently of tumor microenvironment markers. Multiregional transcriptomics uncover cancer cell-intrinsic and low-heterogeneity signals that recapitulate the intrinsic CMSs proposed by single-cell sequencing. Further subclassification identifies congruent CMSs that explain a larger proportion of variation in patient survival than intra-tumor heterogeneity. Plasticity is indicated by discordant intrinsic phenotypes of matched primary and metastatic tumors. We conclude that multiregional sampling reconciles the prognostic power of tumor classifications from single-cell and bulk transcriptomics in the context of intra-tumor heterogeneity, and phenotypic plasticity challenges the reconciliation of primary and metastatic subtypes.

The online registration of advocacy in Iran in practice is different from the past and has a new structure and follows new bylaws in the field of registration rights. There is no necessity for the awareness of the lawyer and client regarding the dismissal or resignation in the instruction for using E-deeds registration websites. In American Law, although the Law of the Notary Public has envisaged some rules regarding online registration, the issue of online registration of advocate and its dissolution has not been mentioned and has only mentioned some general rules. The prevailing viewpoint of the Imamiya jurisprudents and that of Imam Khomeini has similar approach with the instruction of the enforcement of notary instructions regarding the necessity of the awareness of the advocate. The nature of the voluntary dissolution of the advocacy from the viewpoint of jurisprudence and law has been comparatively studied in this research. The findings of this research show that with the establishment of the Online Registration System, and the significant issue of the announcement and explicit information of the client and advocate of dismissal or resignation or implementation of the delegated subject, in order to protect the security of the legal relations of the people and reduce legal disputes and remove the shortcomings of the Iranian legal system, the advocate and the client must be immediately informed through electronic notification about dismissal or resignation or withdrawal or any other issue related to the advocacy by improving the legal mechanisms through ADLiran.ir (Sana)Website. The third persons too should be able to receive information about the authenticity of the documents and deeds through the website of the State Organization for Registration of Deeds and Properties. Thus, the number of the deals that are carried out due to the lack of awareness of the advocate of his/her dismissal will be reduced and the number of legal lawsuits too will be reduced.

IntroductionApplication of agricultural waste composts, in addition to improving soil fertility, has positive effects on the quality of agricultural products and the environment by reducing the use of chemical fertilizers and recycling agricultural waste. Spinach (Spinacea oleracea L.) is a suitable plant for studying the effects of composts and chemical fertilizers due to some physiological characteristics such as high antioxidant activity and oxalic acid, significant amount of mineral compounds and vitamin C, and nitrate accumulation. Despite relatively extensive studies on the effect of different composts on plants, no study has been conducted so far to investigate the effect of grape pomace (GP) composts on plants in Iran. Therefore, the objectives of the present study were: 1- to investigate the effect of different GP composts on yield, nutrient elements, and some physiological parameters of spinach in comparison with two levels of urea fertilization in a pot experiment in two consecutive growing seasons, and 2- to investigate the relationship between nutrient elements and physiological indicators of spinach based on principal component analysis. Materials and MethodsTo investigate the effects of GP composts on yield, nutrient elements, and physiological parameters of spinach (Persius hybrid), an outdoor pot experiment was conducted in a randomized complete block design with eight compost treatments, two levels of urea fertilizer (46%), and a control treatment (C0) in three replications and two consecutive growing seasons (spring and fall). Compost treatments included: High grape pomace (HG) (60-63%) with chickpea straw and alfalfa (HG-Ch-A), high GP with chickpea straw and sugar beet pulp (HG-Ch-B), high GP with alfalfa and sugar beet pulp (HG-A-B), high GP combined with chickpea straw, alfalfa, and sugar beet pulp (HG-All); four other compost treatments included low level of grape pomace (LG) (37-42%) combined with other residues/wastes similar to the first four treatments (LG-Ch-A, LG-Ch-B, LG-A-B, and LG-All). Urea fertilizer treatments included: 150 kg per hectare (C150) (two-stage top dressing) and 500 kg per hectare (C500) (three-stage top dressing). Prior to planting, the composts were separately mixed into the soil (sandy loam) at a rate of 2% by weight(. The first crop was grown for 50 days in May 2018 and the second crop was grown for 45 days in September 2018. In both seasons, plant samples were taken in the early morning at the end of the growing season to determine the fresh and oven-dried weight of shoot and root samples, leaf area, nutrient elements, and some physiological indicators. Some of the shoot samples were wrapped in aluminum foil and stored in a freezer (-20 °C) to determine the amount of chlorophyll (type a, type b, and total), carotenoids, total phenol, vitamin C, and antioxidant activity. Oxalic acid, zinc, iron, copper, sodium, potassium, phosphorus, calcium, magnesium, and nitrate were determined in oven-dried samples. One-way ANOVA was applied separately to spring and fall data, and mean comparisons were made using Duncan's test at the 0.05% level. Principal component analysis was used to determine the relationships between nutrient elements and physiological indicators of spinach. Results and DiscussionThe LG-Ch-A and C500 treatments (in spring cultivation), and the LG-A-B, LG-All, and HG-All treatments (in fall cultivation) had the highest leaf number, leaf area, and yield and were significantly difference from the C0 treatment. The high yield in C500, LG-Ch-A, LG-All, and HG-All treatments was associated with nitrate accumulation in spinach. In both cultivations, there was a significant positive correlation between the amount of P, K, Mg and Zn in spinach and the amount of these elements in the corresponding composts. A synergistic relationship was also observed between P and Mg; P and Zn; and Mg and Zn in spinach. On the other hand, an antagonistic relationship was observed between Ca and Mg in spinach because a high concentration of calcium inhibits magnesium uptake by reducing cell permeability. In both seasons, the chemical fertilizer treatments showed the highest amount of chlorophyll and carotenoids because these compounds increase with increasing nitrogen availability. On the contrary, the amount of antioxidant activity was significantly higher in compost treatments than in chemical treatments. In the spring cultivation, the highest and lowest amount of oxalic acid and oxalic acid/Ca ratio were observed in the LG-Ch-B and HG-All treatments, respectively. Interactions between nutrients and physiological indicators were observed. The uptake of all micronutrients, P, and Mg (in both cultivations) and K (in the fall cultivation) was inhibited by high Ca concentration. With the decrease of micronutrients uptake, an increase in nitrate accumulation may occur because micronutrients are present in the structure of nitrate reducing enzymes. The interdependence between Mg and oxalic acid/Ca (in spring), K and oxalic acid (in fall), and Na and oxalic acid/Ca (in fall) may be related to the role of oxalates in the uptake of mineral ions by plants, since oxalates are usually combined with Na, Mg, Ca, and K in the form of soluble and insoluble salts. ConclusionThe use of urea chemical fertilizer (at two levels) and agricultural waste composts had different effects on the physiological indicators, growth and nutrients in spinach. Spinach grown in soils treated with composts rich in P, K, Mg, and Zn had higher nutritional value. The grouping of treatments by principal component analysis showed that chemical and control treatments were clearly separated from compost treatments with high amount of chlorophyll, carotenoid, nitrate, K, and Zn and low amount of oxalic acid, oxalic acid/Ca ratio, antioxidant activity, phenol, and Na. In general, the use of C500, LG-Ch-A, LG-All and HG-All treatments is not recommended due to nitrate accumulation in spinach.

Background and Aim: Frailty is a challenging syndrome that can lead to injuries, disability, frequent hospitalizations, premature death, and decreased quality of life in old age. This study aimed to assess the frequency of frailty syndrome and its related factors among the elderly population of Kashan city, Iran, in 2020. Methods: This cross-sectional study was conducted on 644 elderly individuals in Kashan, Iran, using cluster sampling. The study utilized a health variables questionnaire, the Tilburg Frailty Index (TFI), and the Mini-Mental State Examination (MMSE) as assessment tools. Results: The mean age of the elderly participants was 67.03±6.8 years, with 336 individuals (52.2%) being women. Among the elderly, 213 (33.1%) were identified as having frailty syndrome. A comparison of different dimensions of frailty revealed that the physical dimension scored lowest while the social dimension scored highest. Logistic regression analysis indicated that factors such as age 70 years and older, living alone, presence of underlying diseases, dissatisfaction with living environment, and history of falls were predictive of frailty syndrome among the elderly (P

Abstract Various processes have been yet considered to study the effect of Lorentz-violating terms and different limits have been determined for the magnitude of Lorentz violation coefficients. In this work, we study the effect of Lorentz-violating terms on B-meson production through pair annihilation ( $$e^+e^-\rightarrow q\bar{q}\rightarrow B+Jets$$ e + e - → q q ¯ → B + J e t s ) in two distinct cases correspondent to axial and vectorial nonminimal couplings in QED and determine the corresponding Lorentz violation coefficients. In both cases, significant modifications are seen with respect to the usual relativistic result. Our analytical results for partonic differential cross section, i.e., $$d\sigma (e^+e^-\rightarrow q\bar{q})/d\Omega $$ d σ ( e + e - → q q ¯ ) / d Ω , reveal an anisotropy which implies new constraints on the possible Lorentz-violating terms.

Background & aim: Infertility is a culturally dependent, challenging experience for individuals and families. Understanding characteristics of Iranian infertile couples and effective coping factors can help counselors in selecting appropriate models. This study assesses the role of spiritual health in predicting stress in infertile women through resilience mediating role.Methods: This predictive correlational study was conducted on 105 women at gynecology clinics of Mashhad, Iran in 2021.They were selected through Convenience sampling method. Tools included Spiritual Well Being Scale, Connor & Davidson Resilience Questionnaire and, Newton, Schrard, and Glavas Perceived Infertility Stress. The instrument used were paper and pen, and they were completed by the participants. Pearson correlation coefficient and structural equation modeling were employed to analyze the data using SPSS (version 22) and Smart PLS software (version 3).Results: Findings revealed significant negative and relationships between spiritual health and perceived stress, positive relationships between spiritual health and resilience, and a negative relationship between resilience and perceived stress. Resilience mediated the negative and significant relationship between spiritual health and stress in infertile women. The value of the VAF index was equal to 0.368 and the total effect of spiritual health on perceived stress was equal to -0.732.Conclusion: Spiritual health and resilience effectively reducestress in infertile women. Recommending psychological counseling based on spiritual health and interventions in suggested.

Abstract Background IgG4-related disease is a fibro-inflammatory disorder with an unknown etiology, which can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are primarily associated with the aorta, there have been sporadic reports of isolated cardiac involvement. Case presentation This paper presents a documented case of IgG4-related systemic disease with symptoms indicative of restrictive cardiomyopathy. Subsequent Cardiac Magnetic Resonance imaging revealed diffuse myopericardial involvement, characterized by pericardial thickening and enhancement, accompanied by subepicardial and myocardial infiltration. Considering the rarity of cardiac involvement in our case, we conducted a thorough review of the existing literature pertaining to various patterns of cardiac involvement in IgG4-related disease, as well as the diagnostic modalities that can be employed for accurate identification and assessment. Conclusions This case report sheds light on the importance of recognizing and evaluating cardiac manifestations in IgG4-related systemic disease to facilitate timely diagnosis and appropriate management.

Abstract Background Contrast-induced nephropathy (CIN) is a form of acute kidney injury (AKI) occurring in patients undergoing cardiac catheterization, such as coronary angiography (CAG) or percutaneous coronary intervention (PCI). Although the conventional criterion for CIN detection involves a rise in creatinine levels within 72 h after contrast media injection, several limitations exist in this definition. Up to now, various meta-analyses have been undertaken to assess the accuracy of different biomarkers of CIN prediction. However, the existing body of research lacks a cohesive overview. To address this gap, a comprehensive umbrella review was necessary to consolidate and summarize the outcomes of prior meta-analyses. This umbrella study aimed to offer a current, evidence-based understanding of the prognostic value of biomarkers in predicting CIN. Methods A systematic search of international databases, including PubMed, Scopus, and Web of Science, from inception to December 12, 2023, was conducted to identify meta-analyses assessing biomarkers for CIN prediction. Our own meta-analysis was performed by extracting data from the included studies. Sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were assessed using Meta-Disc and CMA softwares. Results Twelve studies were ultimately included in the umbrella review. The results revealed that neutrophil gelatinase-associated lipocalin (NGAL) exhibited the highest area under the curve (AUC), followed by cystatin-C, urinary kidney injury molecule-1 (uKIM-1), and brain natriuretic peptide (BNP) with AUCs of 0.91, 0.89, 0.85, and 0.80, respectively. NGAL also demonstrated the highest positive likelihood ratio [effect size (ES): 6.02, 95% CI 3.86–9.40], followed by cystatin-C, uKIM-1, and BNP [ES: 4.35 (95% CI 2.85–6.65), 3.58 (95% CI 2.75–4.66), and 2.85 (95% CI 2.13–3.82), respectively]. uKIM-1 and cystatin-C had the lowest negative likelihood ratio, followed by NGAL and BNP [ES: 0.25 (95% CI 0.17–0.37), ES: 0.25 (95% CI 0.13–0.50), ES: 0.26 (95% CI 0.17–0.41), and ES: 0.39 (0.28–0.53) respectively]. NGAL emerged as the biomarker with the highest diagnostic odds ratio for CIN, followed by cystatin-C, uKIM-1, BNP, gamma-glutamyl transferase, hypoalbuminemia, contrast media volume to creatinine clearance ratio, preprocedural hyperglycemia, red cell distribution width (RDW), hyperuricemia, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP), high-sensitivity CRP, and low hematocrit (P

Osteoporosis is characterized by a reduction of bone mass and destruction of bone structures, followed by high bone fragility and susceptibility. This study aims to evaluate the protective effects of pomegranate seed oil (PSO) on experimental osteoporosis in rats. Twenty-four female Wistar rats were divided into four groups: sham-operated (Sham = 6), Sham with PSO treatment (Sham+PSO = 6), ovariectomized (OVX = 6), and ovariectomized with PSO treatment (OVX+PSO = 6). OVX+PSO and Sham+PSO groups received 0.1 ml of pomegranate juice daily, and OVX and Sham groups received the same amount of paraffin oil. After eight weeks, the femur and tibia bones were removed, and the structure and metabolism of samples were assessed by histological examination. The average thickness of femoral neck trabeculae in group OVX was significantly lower than in groups Sham+PSO and Sham (p < 0.05). Regarding the number of trabeculae in the neck of the femur, a significant difference was observed between groups OVX and Sham+PSO (p < 0.05). Furthermore, trabecular separation in group OVX was significantly more than in the other three groups (p < 0.05). The trabecular separation in group OVX+PSO compared to groups Sham+PSO and Sham was significantly higher (p < 0.05). A histopathologic examination of the upper metaphysis of the tibia indicated that the number of bone trabeculae in Sham+PSO was only statistically significant in the OVX group (p = 0.018). It was also found that the average thickness of bone trabeculae in the OVX+PSO and Sham groups was significantly lower than in the Sham+SO group. The results of the present study suggest that pomegranate seed oil, having estrogenic compounds, can prevent osteoporosis in rats caused by ovariectomy.

Abstract This paper presents a model predictive control (MPC) approach based on the extended disturbance observer (EDOB) for trajectory tracking of a coaxial octorotor unmanned aerial vehicle (UAV). First, the system dynamic model is derived using Newton–Euler relations in the presence of time‐varying centre of gravity (COG); then, a two‐loop cascade structure is presented to perform the trajectory tracking task. Both loops are controlled using MPC with feedforward compensation based on the EDOB to improve disturbance rejection abilities. When the mass changes, the moment of inertia and COG are affected. The EDOB simultaneously estimates the effects of time‐varying mass, external disturbances, and parametric uncertainties in six degrees of freedom. After obtaining virtual control inputs using designed controllers, constrained control allocation is used to obtain rotors speed in a valid range. The proposed control scheme is evaluated using simulation. The simulation results show the ability of the developed control strategy in accurate trajectory tracking and stable flight in different conditions and being robust to uncertainty and disturbance.

Background: The parallel and continued improvements in both infertility treatment and the management of malignancycases have brought to the forefront the potential for fertility preservation. Using ovarian follicular resourcescan effectively improve reproductive capacity and prevent infertility. The primary aim of this research was to try togenerate an appropriate in vivo environment for the growth of the mouse follicles. Hence, the possible effects of theovarian parenchyma cell suspension were explored on the growth and maturation of preantral follicles in vitro.Materials and Methods: In this experimental study, ovarian parenchymal cells were mechanically dissociated frompreantral follicles of 12-14 days-old NMRI mice and then divided into 5 experimental groups (G1: Control, G2: Freshfollicle with fresh parenchyma cell suspension, G3: Vitrified-warmed follicle with fresh parenchyma cell suspension,G4: Fresh follicle with frozen-thawed parenchyma cell suspension, and G5: Vitrified-warmed follicle with frozen-thawedparenchyma cell suspension). The diameter of the follicles and immature oocytes, viability, antrum formation,resumption of meiosis, in vitro fertilization (IVF), and Gdf9, Bmp6, and Bmp15 gene expression were examined ondifferent periods.Results: The diameter of the follicles and the oocytes on days 4 and 8, as well as the survival rate of the follicles upto day 12, were significantly higher in G2 and G4 compared to the Ctrl group (G1: 73.66%, G2:87.99%, G3: 82.70%,G4: 94.37%, and G5: 78.59%). Expression of growth marker genes for G3, and G5 groups was significantly higherthan other groups, which indicated the protective effects of parenchyma cell suspension on follicles damaged by vitrificationsolutions.Conclusion: The growth, survival, and maturation of preantral follicles could be enhanced by co-culturing them withovarian parenchyma cells. Further studies are needed to optimize the conditions for a successful parenchyma cellsuspension-induced in vitro maturation (IVM) to occur in infertility clinics.

This research aims to investigate whether smartphone brands have gender from the perspective of Iranian users and examine the relationship between different genders of smartphones and brand equity with mediating role of customer loyalty. This is a quantitative study that uses inferential statistics to evaluate hypotheses. A standardized questionnaire with 26 questions was used as the research instrument. The statistical population consisted of users of the six most widely-used smartphone brands in Iran (Samsung, Apple, Xiaomi, Huawei, Sony and Nokia), who could participate in the online survey through social networks (Instagram, WhatsApp, and Telegram). The simple random probability sampling method involved 472 samples. Smart PLS version 3 and SPSS version 26 were used to analyze the data. The research was carried out from June 2022 to February 2023. The results show that smartphones have gender from the perspective of Iranian users. Brand femininity and masculinity correlate significantly and positively with customer loyalty to smartphones. Customer loyalty has a significant and positive relationship with brand equity in smartphones. Both brand femininity and masculinity increase brand equity through customer loyalty, with brand femininity having a more significant impact on brand equity than brand masculinity. The biological gender of smartphone users has no relationship with customer loyalty and does not affect their perception of brand femininity and masculinity.

The city of Gotvand in Iran is located in a hot and semi-arid region, where it can be challenging to grow crops. Abiotic stresses such as drought and heat can affect crop productivity during both vegetative and reproductive growth. Melatonin plays a vital role in regulating various mechanisms in plants and acts as a primary defense against environmental stresses. However, its interaction with zinc is not well understood. In the experiment, a randomized complete block design with three repetitions was used. A field experiment was conducted to investigate the interaction effects of zinc fertilizer (ZnSO4) - no application, 1 mg/L, and 2 mg/L and different concentrations of melatonin (0, 25, 50, 100, 200 mg/L. Mung bean plants treated with melatonin and higher levels of zinc fertilizer showed increased vegetative growth and improved yield attributes. The specific combination of 200 mg/L of melatonin and 2 mg/L of zinc fertilizer emerges as a promising strategy to maximize yield components, including pod number, seed number per pod, and seed weight. Notably, this combination proved to be the most effective treatment for enhancing mung bean yield formation which resulted in the highest average seed yield to 1764 kg/ha. It is concluded that melatonin and zinc combination is an effective approach to alleviate environmental challenges such as high temperatures during fluorescence and reproductive growth.

Drought stress is one of the most impactive factors of severe modification in plant physiology eventually leading to a reduction in crop productivity. A split plot-factorial experiment was conducted at the Agricultural Sciences and Natural Resources University of Khuzestan in the 2021-2022 growing season to investigate the effects of irrigation interruption and plant density on spring rapeseed genotypes. The experiment was set up in a randomized complete block design with three replications. The experimental treatments included three levels of irrigation as main plot: (I) (1. Control: no interruption of irrigation, 2. Interruption of irrigation at the beginning of flowering (phenology code 60) until the formation of 50% of the pods (phenology code 75) and 3. Interruption of irrigation at the stage of panicle formation (phenology code 99) until the stage harvest (phenology code 99)) and three levels of plant density (D) (80, 110 and 140 plants per square meter) and canola genotypes (G) (Hayola 4815 and Aram) were arranged in subplots. The study evaluated various sensitivity and tolerance indices to stress, and results showed that the triple interaction effect of IDG on cell membrane stability, photosynthetic pigments, grain protein content, grain yield, and canopy temperature was significant. Significant interaction effects were also observed between IG on grain oil content, DG, and I×D on relative water content leaf (LRWC). The genotype that demonstrated superior tolerance to drought stress had higher values for indices such as STI, YI, MP, GMP, and HM. In general, the highest grain yield was observed in control treatment and density of 110 plants M2 and genotype of Hayola4815 (1572.6 kg. ha-1) and the lowest was observed from interruption of irrigation at the stage of pods formation until harvest and plant density of 140 plants per M2 and Aram genotype (661.87 kg. ha -1).

Abstract The substitution of leucine to proline at position 39 (p.P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations of pathogenicity in cataracts and cardiomyopathy. This study aimed to investigate the effects of the p.P39L mutation on the structural and functional features of human αB-Cry. The mutant protein was expressed in Escherichia coli (E. coli) and purified using anion exchange chromatography. We employed a wide range of spectroscopic analyses, gel electrophoresis, transmission electron microscopy (TEM), and atomic force microscopy (AFM) techniques to investigate the structure, function, stability, and fibrillation propensity of the mutant protein. The p.P39L mutation caused significant changes in the secondary, tertiary, and quaternary structures of human αB-Cry and increased the thermal stability of the protein. The mutant αB-Cry exhibited an increased chaperone activity and an altered oligomeric size distribution, along with an increased propensity to form amyloid aggregates. It is worth mentioning, increased chaperone activity has important positive and negative effects on damaged cells related to cataracts and cardiomyopathy, particularly by interfering in the process of apoptosis. Despite the apparent positive nature of the increased chaperone activity, it is also linked to adverse consequences. This study provides important insights into the effect of proline substitution by leucine at the N-terminal region on the dual nature of chaperone activity in human αB-Cry, which can act as a double-edged sword.

Abstract In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. Currently, such a situation is detected by the clinical judgment of a specialist or precisely by a chest CT scan. However, the lack of accessibility to the CT machines in many poor medical centers as well as its expensive service, demands more accessible methods for fast and cheap detection of lung inflammation. Here, we have introduced a novel method for tracing the inflammation and lung involvement in patients with pulmonary inflammation, such as COVID-19, by a simple electrolyte detection in their sputum samples. The presence of the electrolyte in the sputum sample results in the fern-like structures after air-drying. These fern patterns are different in the CT positive and negative cases that are detected by an AI application on a smartphone and using a low-cost and portable mini-microscope. Evaluating 160 patient-derived sputum sample images, this method demonstrated an interesting accuracy of 95%, as confirmed by CT-scan results. This finding suggests that the method has the potential to serve as a promising and reliable approach for recognizing lung inflammatory diseases, such as COVID-19.

Engraftment by donor lymphocytes in an immunologically compromised host can result in donor T-cell activation against host major histocompatibility complex antigens, with resultant GVHD."nThe acute form of GVHD (aGVHD) is characterized by erythroderma, cholestatic hepatitis, and enteritis. The intestinal symptoms of aGVHD include crampy abdominal pain and watery diarrhea, often with blood. The conditioning regimen and infectious agents may produce similar symptoms. Severe intestinal aGVHD is a life-threatening event and associated with high mortality."nIn this case report, we describe two patients with major thalassemia who experienced acute gastrointestinal GVHD. One of them experienced it after peripheral blood transplantation at day +13, and the other after bone marrow transplantation at day +14. The first presentation was severe GI bleeding, and then 2 litters per day diarrhea. Besides standard prophylaxis with Cyclosporine and Methotrexate, Methylprednisolone 2mg/kg per day commenced because GI bleeding started and afterward supportive treatment means were continued. Following administration of Methylprednisolone, the amount of GI bleeding and diarrhea declined; in addition, the need for whole blood transfusion and blood products decreased. Both children had no problem in follow-up."nEngraftment evaluation by the VNTR method showed 100 percent validity. GI bleeding after transplantation can be a major presentation of aGVHD, which requires precise attention, and on-time treatment. The elimination of other causes of GI bleeding and diarrhea, in addition to the two other factors mentioned above, would increase the survival rate of patients greatly.

This study investigates the horizontal injection of a heavy Newtonian fluid into a lighter viscoplastic ambient fluid, in a large reservoir. The flow dynamics is experimentally captured via camera imaging, laser-induced fluorescence, and particle image velocimetry techniques. The flow parameters include various density differences, injection velocities, and ambient fluid viscoplastic properties. Our analysis identifies two key dimensionless numbers, the Froude number (Fr) and the effective viscosity ratio (m), which includes the rheology of the viscoplastic fluid. Our study also examines the effects of these dimensionless numbers on critical jet characteristics, such as bifurcation length, transition length, deviation length, and jet trajectory, and provides correlations using Fr and m, to predict these characteristic lengths. A regime classification based on the bifurcation phenomenon is also presented in the Fr−m plane.

This study was designed to assess the role of first-line chemotherapy with 5-FU and platinum in the treatment of advanced or recurrent cervical cancer, ten patients with advanced or recurrent cancer of the cervix, with no prior chemotherapy were entered in phase II trial, from Oct. 2000 to Nov. 2001. Eight patients were treated with cis-platinum (50 mg/m2 over 60 minutes in first day) followed by 5-FU (1 g/m2 over 24 hours for 4 days) and two patients with impaired renal function were treated with carboplatin (300 mg/m2 over 15 minutes in first day) followed by 5-FU (1 g/m2 over 24 hours for 4 days) every three weeks, until progression of disease or prohibitive toxicity had been observed. Median age was 52 years (range: 28-70 years). Ten patients received a total of 42 cycles of chemotherapy. The mean number of chemotherapy cycles was 4.2 (median 4, range: 3-7). Three patients had partial response (30%, CI, 1.7%-58.5%). Mean response duration was 198 days (range: 122-273 days). Four patients required red blood cell transfusions; three of them had grade II and one of them grade III nausea and vomiting Two had fever and neutropenia (one developed acute renal insufficiency), and there wee no treatment related mortalities. First-line chemotherapy with platinum and 5-FU for advanced recurrent cervical cancer is promising and deserves consideration for large phase III trials.

The heat capacity of a material is a fundamental property of great practical importance. For example, in a carbon capture process, the heat required to regenerate a solid sorbent is directly related to the heat capacity of the material. However, for most materials suitable for carbon capture applications, the heat capacity is not known, and thus the standard procedure is to assume the same value for all materials. In this work, we developed a machine learning approach, trained on density functional theory simulations, to accurately predict the heat capacity of these materials, that is, zeolites, metal-organic frameworks and covalent-organic frameworks. The accuracy of our prediction is confirmed with experimental data. Finally, for a temperature swing adsorption process that captures carbon from the flue gas of a coal-fired power plant, we show that for some materials, the heat requirement is reduced by as much as a factor of two using the correct heat capacity.