151. In Vitro Antioxidant and Anticancer Potential of the Vegetative and Reproductive Organs of Embelia ruminata.
- Author
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Rambaran, Neervana, Naidoo, Yougasphree, Dwarka, Depika, Mellem, John, Channangihalli Thimmegowda, Sadashiva, and Baijnath, Himansu
- Subjects
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THERAPEUTIC use of antioxidants , *THERAPEUTIC use of antineoplastic agents , *PHYTOTHERAPY , *FRUIT , *IN vitro studies , *MITOCHONDRIA , *DATA analysis , *PHYTOCHEMICALS , *IMMUNODIAGNOSIS , *DESCRIPTIVE statistics , *PLANT extracts , *BARK , *SEEDS , *RATS , *CELL lines , *DOSE-response relationship in biochemistry , *ANIMAL experimentation , *METHANOL , *ANALYSIS of variance , *STATISTICS , *LEAVES , *COMPARATIVE studies , *DATA analysis software , *CELL surface antigens - Abstract
The antioxidant and anticancer potential of solvent extracts of the leaf, stem bark, fruit, and seeds of Embelia ruminata was investigated. The chloroform seed extracts had the highest TAC of 38.50 mg AAE g−1 DW. In the FRAP and DPPH assays, the methanolic seed extracts exhibited the most effective activity (67.63 mg AAE g−1 and IC50 of 3.54 µg mL−1, respectively), compared to the respective standards. In the MTT assays, the hexane seed extracts were the least cytotoxic and had a more pronounced effect on MCF-7 and A549 cell lines (IC50 of 93.1 and 119.5 µg mL−1, respectively) than the control. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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