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155. Pretreatment Endocrine Disorders Due to Optic Pathway Gliomas in Pediatric Neurofibromatosis Type 1: Multicenter Study

Author

Santoro, Claudia, primary, Perrotta, Silverio, additional, Picariello, Stefania, additional, Scilipoti, Martina, additional, Cirillo, Mario, additional, Quaglietta, Lucia, additional, Cinalli, Giuseppe, additional, Cioffi, Daniela, additional, Di Iorgi, Natascia, additional, Maghnie, Mohamad, additional, Gallizia, Annalisa, additional, Parpagnoli, Maria, additional, Messa, Federica, additional, De Sanctis, Luisa, additional, Vannelli, Silvia, additional, Marzuillo, Pierluigi, additional, Miraglia del Giudice, Emanuele, additional, and Grandone, Anna, additional

Published
2020
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158. The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon)

Author

Ozen, Gulsum, primary, Zanfardino, Angela, additional, Confetto, Santino, additional, Piscopo, Alessia, additional, Casaburo, Francesca, additional, Tinto, Nadia, additional, Iafusco, Fernanda, additional, Ozen, Gulsah, additional, Miraglia del Giudice, Emanuele, additional, Tasar, Medine Aysin, additional, Yilmaz, Arzu, additional, and Iafusco, Dario, additional

Published
2020
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159. Demystifying the Pizza Bolus: The Effect of Dough Fermentation on Glycemic Response—A Sensor-Augmented Pump Intervention Trial in Children with Type 1 Diabetes Mellitus

Author

Zanfardino, Angela, primary, Confetto, Santino, additional, Curto, Stefano, additional, Cocca, Alessandra, additional, Rollato, Assunta Serena, additional, Zanfardino, Francesco, additional, Troise, Antonio Dario, additional, Testa, Veronica, additional, Bologna, Oriana, additional, Stanco, Michela, additional, Piscopo, Alessia, additional, Cohen, Ohad, additional, Miraglia del Giudice, Emanuele, additional, Vitaglione, Paola, additional, and Iafusco, Dario, additional

Published
2019
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161. The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function

Author

Perrotta, Silverio, Borriello, Adriana, Scaloni, Andrea, De Franceschi, Lucia, Brunati, Anna Maria, Turrini, Francesco, Nigro, Vincenzo, Miraglia del Giudice, Emanuele, Nobili, Bruno, Conte, Maria Luisa, Rossi, Francesca, Iolascon, Achille, Donella-Deana, Arianna, Zappia, Vincenzo, Poggi, Vincenzo, Anong, William, Low, Philip, Mohandas, Narla, and Della Ragione, Fulvio

Published
2005
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163. Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children

Author

Le Stunff, Catherine, Dechartres, Agnès, Mariot, Virginie, Lotton, Chantal, Trainor, Cecelia, Miraglia Del Giudice, Emanuele, Meyre, David, Bieche, Ivan, Laurendeau, Ingrid, Froguel, Philippe, Zelenika, Diana, Fallin, Dani, Lathrop, Mark, Roméo, Paul-Henri, and Bougnères, Pierre

Published
2008

166. Response to letter to the editor: therapeutic importance of proteinuria classification in children with congenital anomalies of the kidney and urinary tract.

Author

Rivetti, Giulio, Gizzone, Pietro, Di Sessa, Anna, Guarino, Stefano, Miraglia Del Giudice, Emanuele, and Marzuillo, Pierluigi

Subjects
URINARY organs, CONGENITAL disorders, DYSPLASIA, PROTEINURIA, KIDNEYS, HUMAN abnormalities, ANGIOTENSIN-receptor blockers
Abstract

This document is a response to a letter to the editor discussing the therapeutic importance of proteinuria classification in children with congenital anomalies of the kidney and urinary tract (CAKUT). The authors of the response thank the authors of the letter for highlighting the importance of discriminating proteinuria in these children. The current literature primarily supports the presence of glomerular proteinuria in patients with CAKUT, but little is known about tubular proteinuria. Angiotensin-converting enzyme inhibitors (ACE-I) and/or angiotensin II receptor blockers (ARBs) are effective in reducing proteinuria and may benefit patients with CAKUT. Screening for tubular proteinuria in these patients could be useful in identifying those at higher risk of developing chronic kidney disease. The authors declare no conflicts of interest. [Extracted from the article]

Published
2024
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168. Pediatric non-alcoholic fatty liver disease: current perspectives on diagnosis and management

Author

Di Sessa,Anna, Cirillo,Grazia, Guarino,Stefano, Marzuillo,Pierluigi, Miraglia del Giudice,Emanuele, Di Sessa,Anna, Cirillo,Grazia, Guarino,Stefano, Marzuillo,Pierluigi, and Miraglia del Giudice,Emanuele

Abstract

Anna Di Sessa, Grazia Cirillo, Stefano Guarino, Pierluigi Marzuillo, Emanuele Miraglia del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Studies of Campania “Luigi Vanvitelli”, Napoli 80138, ItalyCorrespondence: Pierluigi MarzuilloDepartment of Woman, Child and General and Specialized Surgery, University of Studies of Campania “Luigi Vanvitelli”, 80138 Napoli, ItalyTel +39 081 566 5465Email pierluigi.marzuillo@gmail.comAbstract: Non-alcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disease in childhood. To date, the “multiple-hit” hypothesis is largely recognized as an explanation of NAFLD pathogenesis and progression. Obesity and features of the metabolic syndrome have been closely linked to NAFLD development. Due to the increased prevalence of obesity worldwide, NAFLD has reached epidemic proportions over time. Given its unfavorable cardiometabolic burden (such as cardiovascular and metabolic consequences), it represents a worrying phenomenon needing a more comprehensive and successful management. Laboratory tests and classical imaging techniques play a pivotal role in NAFLD diagnosis, but novel noninvasive alternative methods to diagnose and monitor NAFLD have been investigated. Currently, lifestyle modifications remain the mainstay treatment, although its efficacy is poor because of the lack of compliance. Pediatric research is focusing on multiple alternative treatments targeting the main pathogenic factors such as insulin-resistance, dyslipidemia, gut-liver axis and microbiota, oxidative stress, and proinflammatory pathways. Results from these studies are promising but larger validation is needed. Innovative therapeutic approaches might add an important piece in the complex knowledge of pediatric NAFLD. We aimed to summarize recent insights into NAFLD diagnosis and treatment in children, with a focus on possible future perspe

Published
2019

172. The rehabilitation of children and adolescents with severe or medically complicated obesity: an ISPED expert opinion document

Author

Grugni, Graziano, Licenziati, Maria Rosaria, Valerio, Giuliana, Crinò, Antonino, Maffeis, Claudio, Tanas, Rita, Morino, Giuseppe Stefano, Ambruzzi, Amalia, Balsamo, Antonio, Bellone, Simonetta, Bernasconi, Sergio, Bianchi, Vanessa, Bobbio, Adriana, Bruzzi, Patrizia, Buongiovanni, Carmen, Calcagno, Annalisa, Calcaterra, Valeria, Canali, Teresa, Cerutti, Franco, Corciulo, Nicola, Cotugno, Fortunato, Cuccarolo, Giuliano, D’Amico, Osvaldo, Di Bonito, Procolo, Di Candia, Stefania, Di Pietrantonio, Violetta, Di Pietro, Mario, Filannino, Grazia, Fintini, Danilo, Forziato, Claudia, Franceschi, Roberto, Franzese, Adriana, Galeazzi, Daniela, Gargantini, Luigi, Franca Giusti, Lia, Gualtieri, Antonella, Laura Iezzi, Maria, Iughetti, Lorenzo, Lera, Riccardo, Limauro, Raffaele, Lombardi, Francesca, Lucchesi, Sonia, Macchiaroli, Annamaria, Maltoni, Giulio, Manco, Melania, MIRAGLIA DEL GIUDICE, Emanuele, Modestini, Elisabetta, Morandi, Anita, Mozzillo, Enza, Nanni, Laura, Nicolosi, Alessandra, Pellegrin, Maria Chiara, Peruzzi, Sonia, Peverelli, Paola, Purromuto, Salvatore, Ragusa, Letizia, Rosato, Teresa, Salvo, Caterina, Sartori, Chiara, Sticco, Maura, Elisabeth Street, Maria, Trifirò, Giuliana, Vianelli, Patrizia, Yiannakou, Pietro, IAFUSCO, Dario, Grugni, Graziano, Licenziati, Maria Rosaria, Valerio, Giuliana, Crinò, Antonino, Maffeis, Claudio, Tanas, Rita, Morino, Giuseppe Stefano, Ambruzzi, Amalia, Balsamo, Antonio, Bellone, Simonetta, Bernasconi, Sergio, Bianchi, Vanessa, Bobbio, Adriana, Bruzzi, Patrizia, Buongiovanni, Carmen, Calcagno, Annalisa, Calcaterra, Valeria, Canali, Teresa, Cerutti, Franco, Corciulo, Nicola, Cotugno, Fortunato, Cuccarolo, Giuliano, D’Amico, Osvaldo, Di Bonito, Procolo, Di Candia, Stefania, Di Pietrantonio, Violetta, Di Pietro, Mario, Filannino, Grazia, Fintini, Danilo, Forziato, Claudia, Franceschi, Roberto, Franzese, Adriana, Galeazzi, Daniela, Gargantini, Luigi, Franca Giusti, Lia, Gualtieri, Antonella, Iafusco, Dario, Laura Iezzi, Maria, Iughetti, Lorenzo, Lera, Riccardo, Limauro, Raffaele, Lombardi, Francesca, Lucchesi, Sonia, Macchiaroli, Annamaria, Maltoni, Giulio, Manco, Melania, MIRAGLIA DEL GIUDICE, Emanuele, Modestini, Elisabetta, Morandi, Anita, Mozzillo, Enza, Nanni, Laura, Nicolosi, Alessandra, Pellegrin, Maria Chiara, Peruzzi, Sonia, Peverelli, Paola, Purromuto, Salvatore, Ragusa, Letizia, Rosato, Teresa, Salvo, Caterina, Sartori, Chiara, Sticco, Maura, Elisabeth Street, Maria, Trifirò, Giuliana, Vianelli, Patrizia, and Yiannakou, Pietro

Subjects
medicine.medical_specialty, Pediatric Obesity, Adolescent, Pediatric endocrinology, medicine.medical_treatment, 030209 endocrinology & metabolism, Adolescents, Childhood obesity, Children, Multidimensional approach, Obesity, Rehabilitation, Severe obesity, 03 medical and health sciences, Health services, 0302 clinical medicine, 030225 pediatrics, Epidemiology, Medicine, Humans, Child, Competence (human resources), business.industry, medicine.disease, Clinical Psychology, Psychiatry and Mental Health, Family medicine, Expert opinion, Physical therapy, business, Human
Abstract

Severe/medically complicated obesity in childhood, and particularly in adolescence, is a real disability that requires an intensive and continuous approach which should follow the procedures and schedule of rehabilitation medicine. Given the lack of a specific document focusing on children and adolescents, the Childhood Obesity Study Group set out to explore the available evidence for the treatment of severe or medically complicated obesity and to set standards tailored to the specific context of the Italian Health Service. Through a series of meetings and electronic communications, the writing committee (selected from members of the Study Group) selected the key issues, explored the literature and produced a draft document which was submitted to the other experts until the final synthesis was approved by the group. In brief, the following issues were involved: (1) definition and epidemiology; (2) identification of common goals designed to regain functional competence and limit the progression of metabolic and psychological complications; (3) a multi-professional team approach; (4) the care setting. This paper is an expert opinion document on the rehabilitation of severe and medically complicated obesity in children and adolescents produced by experts belonging to the Childhood Obesity Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED).

Published
2017

176. Pediatric Obesity and the Immune System

Author

Umano, Giuseppina Rosaria, primary, Pistone, Carmelo, additional, Tondina, Enrico, additional, Moiraghi, Alice, additional, Lauretta, Daria, additional, Miraglia del Giudice, Emanuele, additional, and Brambilla, Ilaria, additional

Published
2019
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179. Vitamin D affects insulin sensitivity and β-cell function in obese non-diabetic youths

Author

Corica, Domenico, primary, Zusi, Chiara, additional, Olivieri, Francesca, additional, Marigliano, Marco, additional, Piona, Claudia, additional, Fornari, Elena, additional, Morandi, Anita, additional, Corradi, Massimiliano, additional, Miraglia del Giudice, Emanuele, additional, Gatti, Davide, additional, Rossini, Maurizio, additional, Bonadonna, Riccardo C, additional, and Maffeis, Claudio, additional

Published
2019
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183. Acute urinary retention in a 4-year-old girl

Author

Capalbo, Daniela, primary, Guarino, Stefano, additional, Iannuzzo, Gianpiero, additional, Cirillo, Mario, additional, Miraglia del Giudice, Emanuele, additional, La Manna, Angela, additional, Apicella, Andrea, additional, and Marzuillo, Pierluigi, additional

Published
2019
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184. Nineteen-month-old girl with persistent fever

Author

Marzuillo, Pierluigi, primary, Guarino, Stefano, additional, Casale, Maddalena, additional, Di Sessa, Anna, additional, Golino, Raffaella, additional, D’Angelo, Velia, additional, Menna, Giuseppe, additional, Rossi, Francesca, additional, Miraglia del Giudice, Emanuele, additional, and Perrotta, Silverio, additional

Published
2019
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185. Growth Hormone Receptor (GHR)6Ω Pseudoexon Activation: A Novel Cause of Severe Growth Hormone Insensitivity

Author

Cottrell, Emily, Maharaj, Avinaash, Williams, Jack, Chatterjee, Sumana, Cirillo, Grazia, Miraglia del Giudice, Emanuele, Festa, Adalgisa, Palumbo, Stefania, Capalbo, Donatella, Salerno, Mariacarolina, Pignata, Claudio, Savage, Martin O, Schilbach, Katharina, Bidlingmaier, Martin, Hwa, Vivian, Metherell, Louise A, Grandone, Anna, and Storr, Helen L

Published
2022
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191. How to interpret symptoms, signs and investigations of dehydration in children with gastroenteritis.

Author

Prisco, Antonio, Capalbo, Daniela, Guarino, Stefano, Miraglia del Giudice, Emanuele, and Marzuillo, Pierluigi

Subjects
SYMPTOMS, GASTROENTERITIS, CHILD mortality, DEHYDRATION, HYPERNATREMIA, GASTROENTERITIS treatment, FLUID therapy, ACUTE diseases, DISEASE complications
Abstract

Dehydration is a significant cause of morbidity and mortality in children worldwide. Infants and young children are vulnerable to dehydration, and clinical assessment plays a pivotal role in their care. In addition, laboratory investigations can, in some children, be helpful when assessing the severity of dehydration and for guiding rehydration treatment. In this interpretation, we review the current literature and provide an evidence-based approach to recognising and managing dehydration in children. [ABSTRACT FROM AUTHOR]

Published
2021
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192. The TM6SF2 E167K variant in HIV/HCV coinfection predicts severe liver fibrosis and, only for patients with HCV genotype non 3 severe steatosis

Author

SAGNELLI, Caterina, Merli, M, Uberti Foppa, C, Hasson, H, GRANDONE, Anna, CIRILLO, Grazia, Salpietro, S, Minichini, C, Starace, M, Messina, E, Parisi, Mr, MIRAGLIA DEL GIUDICE, Emanuele, Lazzarin, A, COPPOLA, Nicola, SAGNELLI, Evangelista, Sagnelli, Caterina, Merli, M, Uberti Foppa, C, Hasson, H, Grandone, Anna, Cirillo, Grazia, Salpietro, S, Minichini, C, Starace, M, Messina, E, Parisi, Mr, MIRAGLIA DEL GIUDICE, Emanuele, Lazzarin, A, Coppola, Nicola, and Sagnelli, Evangelista

Published
2016

193. TM6SF2 Glu167Lys polymorphism is associated with low levels of LDL-cholesterol and increased liver injury in obese children

Author

GRANDONE, Anna, COZZOLINO, Domenico, Marzuillo, P, Cirillo, G., Di Sessa, A., Ruggiero, L., Di Palma, M. R., PERRONE, Laura, MIRAGLIA DEL GIUDICE, Emanuele, Grandone, Anna, Cozzolino, Domenico, Marzuillo, P, Cirillo, G., Di Sessa, A., Ruggiero, L., Di Palma, M. R., Perrone, Laura, and MIRAGLIA DEL GIUDICE, Emanuele

Subjects
Male, Pediatric Obesity, Adolescent, Genotype, Triglyceride, Polymorphism, Single Nucleotide, Non-alcoholic Fatty Liver Disease, NAFLD, non-HDL-C, Nutrition and Dietetic, Genetic Predisposition to Disease, Child, Lipoprotein, Membrane Protein, PNPLA3, Allele, Risk Factor, Health Policy, Medicine (all), Cholesterol, HDL, Public Health, Environmental and Occupational Health, Alanine Transaminase, Cholesterol, LDL, Lipase, Italy, Liver, TMS6SF2, Pediatrics, Perinatology and Child Health, Female, Human
Abstract

Background The Glu167Lys (E167K) transmembrane 6 superfamily member 2 (TM6SF2) variant has been associated with liver steatosis, high alanine transaminase (ALT) levels and reduced plasma levels of liver-derived triglyceride-rich lipoproteins. Objectives The objectives of this study were to investigate in a group of obese children the association among the 167K allele of TM6SF2 gene and ALT, cholesterol and triglycerides levels, and hepatic steatosis, and to evaluate the potential interaction between this variant and the I148M patatin like phospholipase 3 gene (PNPLA3) polymorphism on liver enzymes. Methods We genotyped 1010 obese children for TM6SF2 E167K and PNPLA3 I148M polymorphisms. Anthropometrical and biochemical data were collected. Ultrasound imaging of the liver was performed. Results The 167K allele showed an association with steatosis (P < 0.0001), higher ALT levels (P < 0.001) and lower total cholesterol (P < 0.00001), low-density lipoprotein cholesterol (P < 0.0001), triglycerides (P = 0.02) and non-high-density lipoprotein cholesterol levels (P < 0.000001). The subjects homozygous for the PNPLA3 148M allele carrying the rare variant of TM6SF2 showed an odds ratio of 12.2 (confidence interval 3.8-39.6, P = 0.000001) to present hypertransaminasaemia compared with the remaining patients. Conclusion Although the TMS6SF2 E167K variant predisposes the obese children to non-alcoholic fatty liver disease, there is an association between this variant and lower levels of cardiovascular risk factors. Overall, the data suggest differential effects of TMS6SF2 E167K variant on liver and heart health.

Published
2016

194. Prevalence of and factors associated to chronic kidney disease and hypertension in a cohort of children with juvenile idiopathic arthritis.

Author

Gicchino, Maria Francesca, Di Sessa, Anna, Guarino, Stefano, Miraglia del Giudice, Emanuele, Olivieri, Alma Nunzia, and Marzuillo, Pierluigi

Subjects
JUVENILE idiopathic arthritis, CHRONIC kidney failure, HYPERTENSION, BLOOD pressure, ANTI-inflammatory agents
Abstract

We evaluated chronic kidney disease (CKD) (proteinuria or estimated glomerular filtration rate < 60 mL/min/1.73 m2) or hypertension prevalence in 110 children with juvenile idiopathic arthritis (JIA). CKD and hypertension were clustered under the umbrella term of "renal injury". Median age at the last visit was 14 years. Nine out of 110 (8.1%) patients showed renal injury (8 hypertension, 1 proteinuria). Patients with renal injury presented higher age at last visit, longer duration of active JIA, shorter intervals free from JIA relapses, longer duration of non-steroidal anti-inflammatory drugs (NSAIDs) treatment but with similar cumulative NSAIDs dose and higher rate of methotrexate (MTX) prescription, longer time of MTX administration, and higher cumulative MTX dose compared to patients without renal injury. At the last visit, patients with and without renal injury presented similar prevalence of active disease. The cumulative proportion of patients free from renal injury at 240 months since JIA onset was 40.72% for all population; while the cumulative proportion was 23.7% for patients undergoing NSAIDs+MTX treatment and 100% for those undergoing NSAIDs (p = 0.039) treatment. Conclusion:About 8% of the children with JIA develop hypertension or CKD. The main risk factor was longer exposure to both NSAIDs and MTX due to a more severe form of the disease. What is Known •Anecdotal reports showed that rarely juvenile idiopathic arthritis (JIA) could present renal involvement due to prolonged and uncontrolled inflammation (renal amyloidosis) or to long exposure to anti-rheumatic drugs. •No cohort studies investigated renal health in children with JIA. What is new •About 8% of the children with JIA developed hypertension or chronic kidney disease. •The main risk factor was long exposure to non-steroidal anti-inflammatory drugs and methotrexate for patients suffering from a more severe form of the disease. •In JIA patients, periodic evaluation of renal function, blood pressure and proteinuria should be warranted. [ABSTRACT FROM AUTHOR]

Published
2021
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195. Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty.

Author

Aiello, Francesca, Cirillo, Grazia, Cassio, Alessandra, Di Mase, Raffaella, Tornese, Gianluca, Umano, Giuseppina R., Miraglia del Giudice, Emanuele, and Grandone, Anna

Subjects
DNA analysis, ALLELES, FISHER exact test, GENETIC polymorphisms, GENETIC mutation, PUBERTY, GENETIC testing
Abstract

Background: Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017, a first case of central precocious puberty (CPP) caused by PROKR2 heterozygous gain of function mutation was described in a 3.5 years-old girl. No other cases have been reported yet. This study performs a molecular screening in girls with early onset CPP (breast budding before 6 years of age) to identify possible alterations in PROKR2. Methods: We analysed DNA of 31 girls with idiopathic CPP diagnosed via basal LH levels > 0.3 IU/L or peak-LH > 5 IU/L after stimulation, without any MKRN3 mutations. The Fisher exact test was used to compare polymorphism allele frequency to corresponding ones in genome aggregation database (gnomAD). Results: No rare variants were identified. Five polymorphisms were found (rs6076809, rs8116897, rS3746684, rs3746682, rs3746683). All except one (i.e. rs3746682) had a minor allele frequency (MAF) similar to that reported in literature. rs3746682 presented a MAF higher than that described in the gnomAD (0.84 in our cohort vs 0.25 from gnomAD). Conclusions: As for other G protein-coupled receptors (i.e. GPR54), mutations in PROKR2 do not seem to be a frequent cause of CPP in girls. [ABSTRACT FROM AUTHOR]

Published
2021
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196. Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children

Author

Menale, Ciro, GRANDONE, Anna, Nicolucci, Carla, CIRILLO, Grazia, Crispi, Stefania, Di Sessa, Anna, Marzuillo, Pierluigi, Rossi, Sergio, MITA, Damiano Gustavo, PERRONE, Laura, DIANO, Nadia, MIRAGLIA DEL GIUDICE, Emanuele, Menale, Ciro, Grandone, Anna, Nicolucci, Carla, Cirillo, Grazia, Crispi, Stefania, Di Sessa, Anna, Marzuillo, Pierluigi, Rossi, Sergio, Mita, Damiano Gustavo, Perrone, Laura, Diano, Nadia, and MIRAGLIA DEL GIUDICE, Emanuele

Subjects
Male, endocrine system, Pediatric Obesity, Nutrition and Dietetics, Adolescent, urogenital system, Health Policy, Public Health, Environmental and Occupational Health, Gene Expression, Real-Time Polymerase Chain Reaction, Bisphenol A, Cross-Sectional Studies, Adipose Tissue, Phenols, Adipokine, Pediatrics, Perinatology and Child Health, Humans, Female, Resistin, Childhood obesity, Adiponectin, Benzhydryl Compounds, Insulin Resistance, Child, hormones, hormone substitutes, and hormone antagonists
Abstract

Background: Bisphenol A (BPA) exposure has been associated with increased incidence of diabetes and obesity in adults. Objectives: To evaluate whether an association between BPA urinary levels and insulin resistance as well as adiponectin and resistin production and serum concentrations may occur in obese children. Methods: Clinical and biochemical features of 141 obese children were collected. Serum resistin and adiponectin were evaluated. Insulin resistance and urinary BPA levels were assessed. Moreover, the effect of BPA on adiponectin and resistin gene expression in adipocytes from eight normal weight prepubertal children was investigated by quantitative real-time RT-PCR (qPCR). Results: Direct association between BPA and homeostasis model assessment (r=0.23; p: 0.0069) and a strong inverse association between BPA and adiponectin have been found (r=-0.48; p

Published
2015

197. Safety and effectiveness of intranasal dexmedetomidine together with midazolam for sedation in neonatal MRI.

Author

Inserra, Emanuela, Colella, Umberto, Caredda, Elisabetta, Diplomatico, Mario, Puzone, Simona, Moschella, Sabino, Capristo, Carlo, Tedeschi, Gioacchino, Caranci, Ferdinando, Cirillo, Mario, Miraglia del Giudice, Emanuele, Montaldo, Paolo, and Cravero, Joseph

Subjects
DEXMEDETOMIDINE, MIDAZOLAM, MAGNETIC resonance imaging, ADRENERGIC agonists
Abstract

Therefore, the ideal sedation regimen should obviate the need for an intravenous access, but still enable the completion of the MRI without deep sedation and subsequent complications. Keywords: adverse effects; dexmedetomidine; infant; magnetic resonance imaging; midazolam EN adverse effects dexmedetomidine infant magnetic resonance imaging midazolam 79 81 3 12/09/21 20220101 NES 220101 Magnetic resonance imaging (MRI) has been consistently indicated as the imaging modality of choice in children and neonates. While feed and wrap technique may be used to perform MRI scans without sedation, this is not always possible due to MRI sensitivity to motion artifacts and long duration of the procedure. [Extracted from the article]

Published
2022
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198. The impact of the CB2-63 polymorphism on the histological presentation of chronic hepatitis B

Author

COPPOLA, Nicola, ZAMPINO, Rosa, BELLINI, Giulia, Stanzione M, Capoluongo N, MARRONE, Aldo, Macera M, Pasquale G, Boemio A, MAIONE, Sabatino, ADINOLFI, Luigi Elio, MIRAGLIA DEL GIUDICE, Emanuele, Sagnelli E, ROSSI, Francesca, Coppola, Nicola, Zampino, Rosa, Bellini, Giulia, Stanzione, M, Capoluongo, N, Marrone, Aldo, Macera, M, Pasquale, G, Boemio, A, Maione, Sabatino, Adinolfi, Luigi Elio, MIRAGLIA DEL GIUDICE, Emanuele, Sagnelli, E, and Rossi, Francesca

Published
2015

199. Risk factors for carotid atherosclerosis in chronic hepatitis C: no role of the APOC3 variant

Author

ZAMPINO, Rosa, FLORIO, Anna, GRANDONE, Anna, Capoluongo, Nicolina, MARRONE, Aldo, Minichini, Carmine, ADINOLFI, Luigi Elio, MIRAGLIA DEL GIUDICE, Emanuele, COPPOLA, Nicola, Zampino, Rosa, Florio, Anna, Grandone, Anna, Capoluongo, Nicolina, Marrone, Aldo, Minichini, Carmine, Adinolfi, Luigi Elio, MIRAGLIA DEL GIUDICE, Emanuele, and Coppola, Nicola

Published
2015

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